Thank you for this. I thought this was a very informative comment; I am worried about schizophrenia as a disease that might impact my kids. I wanted to ask you for more information, but that is a burden, so I asked ChatGPT instead so at least you wouldn't have to go find links. If you have Other reading besides what is below I would be happy to hear about it.

Here is it's response from ChatGPT (Claude couldn't provide links). My contribution is that I checked the links and skimmed them to see if they supported the statement. They are repetitive (there are only 7 articles linked actually), but they generally support your comment. Of note the PLOS article does not support your comment, and it seems that it doesn't support what ChatGPT says (maybe I misunderstood when skimming it). The stuff in parens below (Looks Like This), was a link in ChatGPT, but the links didn't copy-paste, so I'm going to put all the articles at the top here:

https://www.nature.com/articles/s41380-023-02138-4
https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12...
https://www.who.int/news-room/fact-sheets/detail/schizophren...
https://www.nimh.nih.gov/health/statistics/schizophrenia
https://www.psychiatrictimes.com/view/drug-psychosis-may-pul...
https://psychedelics.berkeley.edu/qa/understanding-your-risk...
https://journals.plos.org/plosone/article?id=10.1371/journal...

The comment you saw online contains some accurate points but also could benefit from additional context and nuance based on available research.

1. Prevalence and Risk Factors of Schizophrenia:

- The lifetime prevalence of schizophrenia is approximately 0.3% to 0.7% globally, which supports the 1% figure as an upper bound (Nature) (BioMed Central) (World Health Organization (WHO)) .
- Schizophrenia typically emerges in late adolescence to early thirties, with men often experiencing onset earlier than women (National Institute of Mental Health) (World Health Organization (WHO)) .
- Factors such as genetic predisposition, prenatal exposures, and psychosocial stressors contribute to the risk of developing schizophrenia (National Institute of Mental Health) (World Health Organization (WHO)) .

2. Triggers for Psychotic Breaks:

- The statement that high doses of psychedelics can trigger psychotic breaks in predisposed individuals is supported by evidence. Drug-induced psychosis, particularly from hallucinogens and cannabis, can lead to schizophrenia in some cases (Psychiatric Times) .
- Other triggers include stress, trauma, and significant life changes, which can exacerbate underlying vulnerabilities (Berkeley Psychedelics) .

3. Impact of Psychedelics on Mental Health:

- Psychedelics can pose significant risks for individuals with a family history of schizophrenia or other major mental health disorders. It is crucial for these individuals to consult healthcare professionals before considering psychedelic use (Berkeley Psychedelics) .
- Research has shown that about 25% of those with substance-induced psychosis may transition to schizophrenia, with the type of substance being a significant predictor of this transition (Psychiatric Times) .

4. General Mental Health Considerations:

- Around 3-4% of the population may experience significant mental disorders other than schizophrenia. For these individuals, the use of psychoactive substances, including psychedelics, can be particularly detrimental (PLOS) . [NOTE: This seems to be an error from ChatGPT, this PLOS article doesn't seem to support this conclusion. As I haven't done personal work on this yet, I don't know whether the statement is supported by other research.]
- Mental health evaluation and professional consultation are recommended before the use of psychedelics to identify potential risks and ensure safety (Berkeley Psychedelics) .

5. Later-Life Considerations:

- The risk of new-onset schizophrenia after the age of 45 is indeed rare, which suggests that older individuals may have a lower risk of experiencing a first psychotic episode triggered by psychedelics (Berkeley Psychedelics) .

For further reading and to deepen your understanding, you may refer to sources like the National Institute of Mental Health (NIMH), the World Health Organization (WHO), and recent research studies on the global burden and risk factors of schizophrenia (National Institute of Mental Health) (World Health Organization (WHO)) (Nature) . Additionally, the Berkeley Center for the Science of Psychedelics (BCSP) provides detailed information on the safety and risks associated with psychedelic use (Berkeley Psychedelics) .