skysight-inc/HackerNews huggingface dataset:
Trying to outrun her disease, researcher creates powerful epigenetic editor
That's not the entirety of homeopathy, just the most commonly shat on ridiculous homeopathic practice
Blackwell hasn't been released yet. I'm a little skeptical of the NVL racks since I've seen no success stories so far.
I would not be surprised that a party would be anti-Russia while still being backed by Russia. Russia doesn't need approbation from the West as much it wants the West to simply destroy itself through stupid politics and corruption.
The PDF has 31 pages.
It seems it’s a stretch to call it a book, as it’s a scroll just 6,000 words long. Shorter than a journal article.

The oldest complete dated document would seem better.
It’s even cheaper to offer nothing. Some humans are just quite something.
Diabetes patients on GLP-1s instead of insulin have lower cancer risk
Are you sure it was not a naturopath? Because the fundamental "principle" behind homeopathy is exponential dilution.

An homeopathic pollen formulation would start with 1 mg of pollen in a litter of water, a milliliter of that solution would be diluted in a liter of water and this process would be repeated a few time. In the final solution, it would be impossible to detect even a trace of the original pollen.
Do Brits ever remake American shows? And if so, do they label their own as (UK)?
Generative AI appears fantastic aid for many smaller tasks where there's enough training data, and correctness of the answer is subjective (like art), or easily verifiable by a human in the loop (small snippets of code, checking that summary of an article matches the contents of the original). Generally it helps with the tedious parts, but not with the hard parts of my job.

I don't have much belief in fully autonomous generative AI agents performing more complex tasks any time soon. It's a significant productivity boost for some jobs, but not a total replacement for humans who do more than read from a script, or write clickbait articles for media.
They should add AI that improves audio as well. Some older MIT and Stanford course playlists have pretty bad audio. It would be nice if they could just enhance the audio in place.
How to Fold a Suit, According to King Charles's Former Suit Maker
Is that "homeopathic" or "herbal / dietary supplement"?
Boop boop boop. Boop boop boop. Boop boop boop.
How old is the baby now? Six months…
But why are businesses like CVS hawking snake oil while also having trained pharmacists on staff.
> Your suggested countermeasure does not do anything to change those odds.

Actually it does change. Even if you hit the exact correct TOTP code, the system still deny your login because of throttle rules and you can't tell on the client side.
The century in which the switch occurred (which was different in different countries) was shorter than the others. As were the decade, year, and month in which the switch occurred.
While I hear this argumentation a lot, I still struggle with this:

If you have "mild problems, which would normally heal on their own", buying no medication at all would be even cheaper.

And from an ethical point of view, the idea of financing a whole (homeopathic) industry that uses your money to produce fake science, even with a single cent, should make one shudder, shouldn't it?
https://archive.ph/wtVLJ
DOD ip blocks are/were often used as faux-private since there are massive blocks unused

that can get interesting https://news.ycombinator.com/item?id=10006534
Because a lot of those bottles also make claims that are in violation of the FDA rules. The label is not sufficient.

They need to avoid making claims that they can treat or diagnose some condition. They do their best to hint at it without crossing the line, and frequently blatantly do cross it. The FDA does not have anywhere near the manpower to enforce it. And when they do finally get around to it, the brand vanishes, and a new one appears with exactly the same product lineup.

The sector has long lost any entitlement to benefit of the doubt. They are knowingly making illegal claims and using a disclaimer as a fig leaf even though everything else on the package contradicts it.
[dupe]

Please don't post wayback links unnecessarily. Content still fresh and available.

Discussion here: https://news.ycombinator.com/item?id=40856329
Such devices are indeed already on the market. They are fancy water filters, nothing more, nothing less.
I like to think of the 'car factory' analogy - it's populated by robots that are in some respects far superior to humans, and are doing 90% of the labor. Some ancient futurist, not having seen one before, could correctly predict that 9 out of 10 jobs will be done by robots, and arrive at the incorrect conclusion that robots have rendered humans obsolete.

In actuality, humans are still needed for the 10% the robots can't do well, or serve to enhance the productivity of humans.

I predict AI is like this and going to be for a while - it can clearly do some stuff well and sometimes better than humans, but humans will have their niches for a while.
> Another is that common fruits like pears, apples, and citrus contain drug like chemicals that alter the metabolism. This is super potent in grapefruit and has been known to cause fatal drug interactions in people on prescribed medicine.

Grapefruit does not "alter the metabolism." Furanocoumarin binds to a receptor in the gut which causes some medications to pass through the gut much faster than normal which affects the level of the medicine in the blood.

That has nothing to do with "metabolism."

It also only affects some medications.

You might want to refrain from commenting on medicine until you have an actual science-based education in it.
On hot days, I’ll drink nearly two gallons. Most days 1.5 gallons. Just water. I have a very large cup that is a pint and a cup. I’ll drink 8-10 of those a day. Though I eat a lot of salty/dry foods. America baby. If I go for a long bike ride I’ll be able to wring my shirt/sweatshirt and sweat will come pouring out.

After a long ride I’ll drink nearly half a gallon of water. Likely excessive but it tastes really good.

It’s likely there is a very large variation in the water people need to consume. During college, I knew individuals that would drink merely a glass or two all day (minus before/after going to the library). Very small water bottles. Though these individuals looked to be <100 lbs.
Both can pretty easily do you serious harm if taken too far, up to and including death. Thankfully the survivable "buffer space" of "too far" is large enough that people generally pretty rarely ever get to the actual danger zone.

Here's one fairly famous(ish) example of over-hydration being fatal: https://www.nbcnews.com/id/wbna16614865
> What does that even mean?

It means just what it says. In the common calendar, the year after 1 BC (or BCE in the new notation) was 1 AD (or CE in the new notation). There was no "January 1, 0000".
It's something where you have to read the introductory material, and then find out the important part is elsewhere. In this case, in a blog post yet to come.
I'm a medical student with FOMO and who loves AI stuff. I have about 70 public github repos that nobody uses even though I take pride in at least trying to use good code and documenting everything.

Here's a highlight (edit: more like an ego dump)

I couldn't keep up with my news so I made the perfect summarizer that goes through the thought process of the author : https://github.com/thiswillbeyourgithub/DocToolsLLM/

I needed an AI based system that go through my anki cards, but might as well make it able to read dozens of file formats. Now I can put entire medical youtube playlists, conferences, anki databases, hundreds of PDFs and ask a single question across all of them at once : also https://github.com/thiswillbeyourgithub/DocToolsLLM/

I couldn't keep up with my anki review so I made an embedding based review reranker (one of my first ever project!) : https://github.com/thiswillbeyourgithub/AnnA_Anki_neuronal_A...

I needed to make my sleep more efficient : micropython to the rescue : https://github.com/thiswillbeyourgithub/sleep_tracker_pineti...

I wanted to store everything and anything in Logseq ttps://github.com/thiswillbeyourgithub/LogseqMarkdownParser and https://github.com/thiswillbeyourgithub/LogseqPDFImporter

I was so late for my medical exams I needed to learn FAST : I made an incredible app that turns hours long recordings of you talking aloud while reading your PDF into hundreds of flashcards that learns to mimic your style by using previous validated answers etc. Using stt and LLM. This one is not out yet but will be.

Also I made scripts that automatically reformulate old bad anki cards into more appropriate ones.

As well as creating complex mnemonics stories and images automatically added to your anki cards. Not yet public.

I needed help to sort through my many todos so I made an ELO based reranker made to be used in the CLI (careful, wet paint) : https://github.com/thiswillbeyourgithub/mini_LiTOY

I wanted my anki OCR to be more legible so I made tesseracts try to preserve spacing : https://github.com/thiswillbeyourgithub/OCR_with_format

I lost my voice for some time but needed to be heard so I made speech.sh : https://github.com/thiswillbeyourgithub/speech.sh

And quite a few others.
Alternatively: the third millennium.
> how many human endeavours have one or all of these things?

You want a binary answer as in "it never happens with X"? Because for most kinds of project, we say it didn't go well when 1 or 2 of those happen, while we declare a victory in software if we manage to avoid 2 of them.

> And then how much software is actually pretty great?

And now I'm curious about your bar for "pretty great" software. This is obviously subjective, but most people wouldn't look at any practical software and call it great.
Aren’t they normally sold as supplements’ not medicines, to circumvent regulations?
Around 1800 CE in the United States roughly 30-50% of children didn't make it past 5.

But yeah, sure, a Neanderthal child dying at 6 years old was the result of neglect and not that there was extremely high child mortality prior to the very recent modern era.
It makes money
Nit^3: this point would have been effectively conveyed as '"Google's internal style guide"'. By putting only "internal" into quotes, you call into question whether its public existence invalidates the internal nature of it.

Whereas the respondent said this:

> Google has a “style guide” for internal c++ code

This is a style guide for definitely-internal c++ code, with the internality of the style guide itself unspecified. I'm not sure what the effect of the scare quotes around "style guide" is meant to be, just that it doesn't move the internal part next to the style guide part.

Putting the whole thing in quotes, rather than just "internal", questions whether the guide you found is the guide referred to, rather than the internal nature of the style guide itself, which the quoted sentence takes no position on.

This has been your daily dose of Hacker News style guides for discussing style guides.
THE PLACEBO EFFECT:

It works even when you know it's a placebo.
Microbiome composition varies based on sampling time, mouse study finds
Two you should look at imho

- Void Linux

- Chimera Linux

I can’t decide on a favourite, but they’re both very interesting projects.
The American and French Revolutions are a pretty big deal on the road to modern democracy, as well as being tied to 1700s Enlightenment ideals. Everyone educated should know this.
Well, the placebo effect is real so the products do actually work. Weird line, sure, but still.
Ask HN: Pareidolia (walls) and (visual) LLMs. Has anyone made any efforts?
fwiw, Ente's Auth works fully offline. E2EE backups / account creation is optional.

If you have an RPi that is accessible over a network, you could self host it as well: https://help.ente.io/self-hosting/
They are now called global action to end smoking. Makes you think about all the so called good organizations that just don’t seem to be able to solve the problem. Quite smart though; fund an opposing team, market them , they become a lighting rod for all activism, then make sure to knee cap their ability to do anything through highly burrocratic and convoluted power structures, ensure your team is the CEO. And, ensure that they consider so many variables such that they can never make decisions. Or endlessly have good people write reports that no one reads. In fact, make sure that no one reads them and, have authorization on the final draft to ensure only vague and implausible solutions are proposed. So smart. laughable really.
Newsflash: purveyors of death sticks are unethical
That roughly amounts to "avoid all recorded music" right now.

If you don't like music, sure... but I'm not willing to be that ascetic.
I don't think we can really say what path would lead to superintelligence (for whichever definition you desire) in the near future. Perhaps it is technically possible to achieve merely by making an embodied agent with enough different tricks in a single model (which I see as a matter of continued improvement along current lines), or maybe it requires several new things we haven't conceived yet.

Personally, my area of interest is scientific discovery. Could a model not dissimilar from what we have today, if asked a cogent question, not answer it with an experiment that could be carried out? For example, one of the most important experiments, Avery-MacCleod, which proved (to the extent that you can prove anything in biology) that DNA, not protein, was the primary element of heredity, is not all that complicated, and the mechanical details seem nearly in reach of modern ML techniques. Similarly, could the ML model provide a significant advance in the area of understanding the molecular function in intimate detail of proteins as determined by their structure (which AlphaFold does not do, yet), complete with experimental instructions on how to verify these hypotheses? As of this time, my review of modern ML methods for science suggest we have made some advances, but still have not passed the "phase transition" demonstrating superscientist-level understanding of any field. But perhaps it will just fall out naturally from improved methods for media generation/parsing and ad targeting.

I continue to remain hopeful that within my remaining 20-40 or so years (I'm a typical american male, age 51, with a genome that contains no known risk factors) I will see something like what Vinge describes in https://edoras.sdsu.edu/~vinge/misc/singularity.html in a way that is demonstrable and safe, but honestly, I think it could go in any number of directions from "grim meat-hook future" to "unexpected asteroid takes out human life on the planet, leaving tardigrades to inherit the earth" to "kardyshev-scale civilization".
There's more to it. I am someone who has had medical problems that took years to diagnose. I had doctors who were terrific and I had doctors be almost accusatory when the tests they ran came back negative. When the medical establishment fails you it's tough, and there plenty of snake oil salesmen who are happy to sell you a cure THE MEDICAL ESTABLISHMENT DOESN'T WANT YOU TO KNOW ABOUT!!! I can see the allure when there's literally no one else to turn to.
> and the folks predicting we're just around the corner have been recognized once again as shysters, hucksters, and charlatans

Why? Can you see the future?
No one (serious) was claiming that GPT-4 is superintelligence, it’s about the rate of improvement.

There has only been 6 years between GPT-1 and GPT-4, and each iteration brought more and more crazy emergent behaviour. We still don’t see any sign of the scaling laws slowing down.

I work in ML research, and personally don’t believe ASI is just around, but I talk everyday to researcher that believe so, they don’t say that to swindle anyone’s money (they have extremely well paid 9 to 5 jobs at Goog/MS/OAI, they aren’t trying to raise money from VCs), they only believe so due to the rate of improvement.

Claiming, barely 18 months after GPT-4, when we haven’t yet seen any result from the next jump in scale, that it’s all baloney is a bit premature.

Btw in research time, 10 years from now is « around the corner ».

Now for the VC-chasing folks, their motivation is an entirely different story.
Agreed. It is stupid and vile to use a few words.

I am all for enforcement if it reaches a significant audience with commercial interests. But now anyone for any reasons gets this crap.
Other scammers might be even less scrupulous and sell stuff which is actively harmful.
Having said that, it's using Material UI which has only just committed PRs to remove IE support in a yet to be released version, so this probably works with IE even if the author doesn't intend to support it.

Just an observation that the open source ecosystem has been very patient with Microsoft – no obligation on anyone to support anything that doesn't suit them!
I use Nvidia's Broadcast tool to do it locally on my GPU in realtime. It works fairly well and has made some older videos, especially courses or presentations at conferences satisfactory to watch but I agree it would be great if YouTube could automatically provide it as a tool as well.

I'm hoping to find a tool that removes umms and ahhhs, mouth clicks and other annoying tics.
>"We developed methods of building nested layers of abstractions, hiding information at multiple levels. We took the problem of constructing software and morphed it into towering layers."

https://www.joelonsoftware.com/2002/11/11/the-law-of-leaky-a...

https://en.wikipedia.org/wiki/Tower_of_Babel

https://en.wikipedia.org/wiki/Hierarchy

https://en.wikipedia.org/wiki/Abstraction

https://en.wikipedia.org/wiki/Abstraction_(computer_science)

(Compare and contrast!)
Ente has an Authy export guide. https://help.ente.io/auth/migration-guides/authy/

You don't even need to have Authy installed. The script pretends to be a new device and gets the keys from your backup. (You might need to run chmod +x for execute permission)
They are powerful placebos, so the believers have become permanently duped.
No idea. And I won't be reading it either.

Someone wanting the world's attention because of a crisis really should not add extra friction.
As I said twice, whether that date actually existed or not is irrelevant.
Name Combiner
I call this the "filter changing problem". No matter how complex you make the technology, somebody still has to change the oil filter (or do whatever other maintainence is required to keep the system running). Sort of like ML-SRE, for those who are familiar with the concept.
AI Interviewer
Invue AI offers a live, ai interviewer that interacts with job candidates in real-time. Our AI asks questions, understands responses, and adapts the conversation accordingly. It provides immediate, detailed assessments to employers, streamlining the hiring process. This approach saves time, reduces costs, and allows companies to evaluate more candidates fairly and consistently, improving overall hiring efficiency.
I feel the same way. I get far too many “hey!” Or “Hello?” “What’s up?” messages on my phone that never say another thing. Any family/friend of mine knows me well enough to try more than once to get my attention via messages, and 99% of them should probably be in my contact list already and I’ll hear the beep.
Fwiw I thought open source meant the source was available. "FOSS" or "MIT" mean do whatever you want with it
If it worked and had the scientific evidence behind it then would be called medicine.
I've long been partial to this formulation:

> 1972 - Dennis Ritchie invents a powerful gun that shoots both forward and backward simultaneously. Not satisfied with the number of deaths and permanent maimings from that invention he invents C and Unix.

Some of us learn to lean to the side right before pulling the trigger...

http://james-iry.blogspot.com/2009/05/brief-incomplete-and-m...
I'm pretty sure the document is not directed at anyone in the West (big hint: it's not in English) but rather for internal consumption. Hence also listing traditional Chinese medicine, which is irrelevant for the West, even historically, but plays an important domestic propaganda role as an equal-opportunity competitor to "Western" (i.e. evidence-based) medicine.

As for the technology used to fight wars, as early as the Ming dynasty, cannons were re-imported from Portugal https://en.wikipedia.org/wiki/Hongyipao . Technology transfer has rarely been a one-way street.
Grapefruit contains compounds that inhibit Cytochrome P450 and this will affect how various drugs will be metabolized. That is a very direct effect on metabolism and will affect a variety of drugs, but certainly not all of them.
Benchmarking LLM Inference Back Ends: VLLM, LMDeploy, MLC-LLM, TensorRT-LLM, TGI
They can, they just shouldn't expect to be paid for it.
Very much false.

1. Under the Federal Food, Drug, and Cosmetic Act, homeopathic products are subject to the same requirements related to approval, adulteration and misbranding as other drug products. https://www.fda.gov/drugs/information-drug-class/homeopathic...

2. Homeopathic products are "classified as either over-the-counter (OTC) or prescription medicines." https://www.chpa.org/about-consumer-healthcare/faqs/faqs-abo...
They are not theoretically guaranteed they are in practice though. 2^128 and 122 are big numbers. Even if you are producing a billion per second you have a 50% chance of not getting a collision for 100 years.
That's not the only mechanism (see other response also).

https://en.wikipedia.org/wiki/Grapefruit%E2%80%93drug_intera...
And while we are at it, Tim Apple
> Hardware will continue to leapfrog the pace of software innovation and things will keep getting better.

This is wishful thinking. Try running Windows 2000 on era-appropriate consumer hardware and tell me just how much better off we truly are now with bloated and unresponsive web apps.

> Also, it’s easy to look at the past with rose tinted glasses. Modern softwares are bloated mess but still a million times more productive.

What metrics are you using to quantify "a million times more productive"?
I made a stupid little utility to let me calculate how long to cook something in the microwave. Most instructions are written for 1000w or 1200w microwaves, and mine is only 800w.

I put a little NFC chip near my microwave, so I can tap it with my phone to open it up when I need it.

I also run into various scenarios where I need to copy some text, do something with it, and check it off a list, over and over. It’s not worth automatic each ad-hoc thing, so I made a little webpage where I can put it all my items and when I click one, it copies the next to the clip board, checks it off the todo list, and keeps track of the last item copied for reference.

Nothing huge, just little helpful things like that.
IMO using bigserial by default is wrong. Use whatever data type is appropriate. Not every table will grow to 4 billion rows and not every table will grow to even 60k rows. ID data type leaks to every foreign key referencing given table. Many foreign key usually will be indexed, so this further degrades performance. There are multiple data types for a reason.
Not the problem I'm having at all.

What happens in my case is that Explorer forgets the "When using multiple displays, show my taskbar apps on..." setting. It just randomly changes the setting in memory: I can either change the setting back and forth, or restart Explorer, and then it works correctly.

It's the oddest bug I've seen.
People want to buy them and we live in a free country.
Not simple but universal, yes.

It's also not pattern matching, though.
Lately it seems these are always revised down after the initial release. In a month we may find out that the real numbers are even worse.
Yep, I think my first modem was 2400 baud and even that was slightly faster than I could read.

Sluggish modem websites have no one to blame but themselves.
The only question I have is whether Goldman is shorting NVIDIA..