skysight-inc/HackerNews huggingface dataset:
Or with writing about it. But there's an implicit "if you haven't already written about it". We might wonder what other implicit preconditions there are.

Similarly, if walking North always brings you closer to the North Pole, then you can never reach the North Pole without walking North, or at all. But look out for oceans.
This idea of "curing cancer" as if cancer was a monolithic disease really needs to die.

Cancer is just a catch-all term for somatic cell mutations that become unmanageable. There are as many ways to get "cancer" as there are ways to mutate cells into these sort of uncontrollable states. And there are cures for multiple cancers today (Imantinib, Herceptin, etc). There actually have been enormous recent strides in drugs like PD-1 inhibitors that do have a broad spectrum affect against cancers, but I think outside of this one particular example, the real math problem is how do you expect to contain a mutational state of a cell with 10000x ways to reach that state with a single, or even handful of drugs?
After one year...

Twitter: 600 million active users

Threads: 175 million active users (28%)

That's pretty good for 12 months.
What manner of insanity is that memory map. Start: 0x80000000. End: 0xFFFFFFFF. Size: 4GB....what now? Did I forget how to subtract?
And often CPU as well if your machine has a reasonable number of cores.
Well for the LLM would be a calculator.
Why do people write frameworks on top of programming languages that other developers wrote?

Feels like a similar kind of energy, but your scenario is easier: if it goes away they could find new maintainers or take it up themselves.
Let’s not forget the 10% layoff rule just to hire another 10% in the next 6-12 months. Good for everyone, am I right /s?
I wrote a few apps when I realized that I couldn't find anything ready-to-use for my tasks.

For example:

Conversion between .env and .json configs: https://github.com/magicxor/EnvJsonConv

Web scraping different platforms and sending results to my favorite messenger: https://github.com/magicxor/ExtensibleMessageBroker

Transformation of copied text using regular expressions: https://github.com/magicxor/ClipboardTransform

It usually takes 3-10 days to implement and polish the core functionality. Some apps I use on a daily basis (e.g., bots in my favorite messenger), and some 1-2 times per month.
Oh yeah they had the shakers here in Europe for a while. They where a total bust. Basically a salad stuffed into a drink cup. Made no sense at all.

Seriously who came up with that shit.
It's not an exact dupe, but the main part of the content is too similar. You can send an email to dang so he can take a look and give an official opinion hn@ycombinator.com
Part of it is the EPA and other federal regulators treating small companies the same as the 4 oligopolists.

https://nwmpa.com/epa-impact-statement/

We buy 1/2 a carcass worth of beef at a time from a small local place, and the cost is a lot better than costco. But we're worried at the immense pressure small shops like that are now under due to the enormous compliance costs for regulations that make little sense for the scale of work they do.
My take on a more dynamic election system is to set up a window during which primaries/caucuses may be held, then allow the states/districts/&c. to choose a date based on their metrics from the previous election --- in particular voter registration percentage (this would probably get everywhere to do motor voter) and voter turnout percentage --- no choosing the same or adjacent dates.

I think it'd be awesome to have a little variety in initial primary settings EDIT: and for the ordering to be dynamic and to change from cycle-to-cycle.

The other thing to do would be to rate limit donations --- corporations are people? Money is speech? Fine. Set the maximum donation to be some multiple of the current Federal minimum wage (about what one could reasonably expect an individual to donate) and each political donation must be done individually in that amount, and any donation after the first must be done as a printed check mailed in a first-class envelope with a handwritten note explaining what the donation is for.
5 or 6 most days. I’m of course happy to do more in sprints when duty calls. Working at 100% is fun - as an exercise. Like training with weights on. Maybe your site gets DDOS’d. Maybe your database has a critical issue. As long as you’ve done some prep these are recoverable issues. And solving big problems tells you and your boss that you’re important.

But honestly most of the time I’m able to take my best thinking hours of the day, put those into the job, and get 90% of the output with much less than 90% of the time. The worst thing you can to is try to fill the time and create a bunch of tech debt. Artificial time scarcity keeps things lean.
I semi-regularly get migraines, maybe a handful a year.

Nearly every time it's associated with a night of insomnia - I do everything the same, no coffee or alcohol or anything, no late work or screens. The same bedtime routine, I just.... don't sleep.

I'm not sure how to draw the line of cause/effect between the two. Is the lack of sleep causing a migraine the next morning? Or is the insomnia some symptom of whatever then becomes the symptom of a migraine.

Or even if such a line exists, I think the association is strong enough the two are related, but I know memory and the brain making things fit patterns can be misleading.
>It's important to understand that there'll never be "a cure for cancer". Cancer is not a single disease. It's more like a meta-disease. There are tons of different types of cancer and the path for treatment is not the same.

I'll make an even border generalization. Cancer is one of the hallmarks of aging. And aging itself somewhat loosely defined will include all types of cancer and what are typically regarded as non-cancers, like Alzheimer's.
Saying we can never cure cancer because it's not a single disease doesn't quite strike me as accurate.

I'm not an expert so feel free to correct me, but my understanding is that there are plenty of other animals, such as the naked mole rat, that are effectively immune to all forms of cancer because while it might not technically be one disease, all forms of cancer share enough characteristics that there exist a small group of genes that are able to suppress it or develop an immune response that effectively prevents a tumor from growing.
Yet its narrow applicability still hasn't stopped the courts from authorizing blatant violations of it. The verdict of Mitchell v. City of Henderson is appalling.
There is zero chance right now of any battery storage being in the $3/kwh range. Even in the manager-of-the-battery-factory-took-some-home-for-cost situation.

That would be one of these [https://www.amazon.com/LiFePO4-Battery-Perfect-Applications-...] for $3, if we were only talking batteries. No MPPT or line chargers, etc.

That’s about what the plastic and internal bus components are going to cost for that battery, with no actual battery internals.
Auto increment ID’s also leak information.

Random UUID’s shouldn’t, but will impact performance, which in most cases will have more concrete impact on the business.

There is no such thing as a free lunch.
Eh, using 2 digits for year is a lot ‘more wrong’ than 8 bytes. Since all (current) known use cases can fit in 8 bytes for the conceivable lifespan of human civilization.

2 digit years don’t even support the use case of ‘store the current year’ fully.
From what I understand, the author is persuading library authors to stop compiling TS->JS, and instead ship your TS files to the users over npm. I like the idea of it, but will it actually work in practice? What if some dependency only compiles with some version of tsc? What if it needs different tsconfig-s?
> Seems like that's a decent wage for those parts of the world?

20 eight hour days at 1 dollar is not much higher than Kenya’s minimum wage (around 120 a month)

Not terrible I guess but also not great even by 3rd world local standards

To make it count as decent you’d need to go somewhere poorer than Kenya
As the writer says, you’re not alone if you have customers cheering/jeering you on. If you’re lucky you’ll even have customers throwing money at you while lamenting their fears of having to settle for an incumbent.
I suspect that what rules apply to space habitats will depend on who's got the power to make and enforce those rules at the time it becomes relevant.

Besides, if the President declares that you must as an official act, alas you must or face the unmitigated consequences (according to recent rulings).
Contrary to the political priors of VCs, I think the real answers are pretty mundane:

1. Funding. Drugs have a low probability of success and a long lag time. Investors think in discount rates. A high-risk venture like biology is less appealing than an advertising-based tech platform with zero marginal costs.

2. Costs. Biology uses a LOT of proprietary instruments, kits, and chemical reagents. A lot. It also needs a lot of manual labor that would be difficult to roboticize.

3. Time. Biological experiments operate on biological timescales. Code takes seconds to run. Cell cultures take a day to grow. Even fancy new multiplexed sequencing assays take a while. You have the library prep time, the sequencing, and the downstream analysis. Its a long process. Now imagine waiting years and years to see if a drug in clinical trial prevents Alzheimer's.

4. Complexity. How do you make an equation for a giant network of weakly-interacting parts? Biology is a very "data-driven" field for this reason. The introduction of new microscopy, chemical conjugation techniques, and high-throughput assays has only made things worse. I genuinely hope some black box AI will be able to help us make sense of this mess and cure cancer. But medicine is full of interventions and incomplete prior histories, which will make naive association models hard to use.
> There is a lot of basic research done that does make a difference but where that difference is unknown to the original researcher -- perhaps separated too far in time. I have found value in decades-old PhD theses in the life sciences, mainly physiology.

Have you ever tried tracking down the author to express your appreciation? It might make their day (or month!).
I wish civilized world would recognize how dangerous russia is and do something about it. We need some kind of “russian Disinformation and Propaganda Awareness Day” or something.
Reminds me of this...

William F. Buckley didn't just support the cold war — he actually participated in early CIA actions. In 1951 he became a deep cover CIA agent stationed in Mexico, reporting directly (and only) to E. Howard Hunt (who would later play a role in the Bay of Pigs invasion). Two years before his death, 79-year-old Buckley remembered a strange aftermath to his CIA work more than half a century before:

In 1980 I found myself seated next to the former president of Mexico at a ski-area restaurant. What, he asked amiably, had I done when I lived in Mexico?

Buckley's honest answer? "I tried to undermine your regime, Mr. President."*

https://www.10zenmonkeys.com/2008/02/28/the-collected-contro...
I don't have any data. I'm speaking strictly with the knowledge that Tegra X1 powers the Nintendo Switch and that the Nintendo Switch has a broad base of engine support. Normally, if it were a bad platform to work on, I expect that we'd have heard about it by now from third party developers (e.g.: CELL architecture)
I too am highly perplexed
Problem with bug reports: You don't need to be a programmer to report bugs well, and the maintainer usually will fix the bug better.

I hack and track down the lines of code responsible for the issue (which allows the maintainer to quickly patch the issue), but can't confidently implement large patches as I often don't even know the libraries being used.

"Real programmers" know exactly how the codebase is structured and confidently fix both their own and other people's bugs. (Maybe this is just my lack of confidence)
Minimum wage is 120 so at normal hours 160 is above but also not massively
This doesn't really seem to address my most common packaging pain points in the JS/TS ecosystem (which is the inability to easily use ESM in legacy commonjs applications) but maybe I'm just working in the wrong area?

I think the author seriously exaggerates the difficulty of creating type declaration files. It's literally one boolean setting in your tsconfig. I wish they would have given more time to proving the alleged pain points with some examples rather than just telling us how great this new feature is. I personally don't see how this changes my life at all, and I'm a full time JS/TS dev.
You may have just seeded something
The Urban Nomad: Portable, Mobile, Compact Lifestyle
Farming is already pretty scaled in general, right? Napkin math with Claude's help says we can feed everyone with about 250k workers. The internet says we are currently using like 2 billion. Plenty of room for optimization even without additional technology advancement.
That's actually the system working as intended. There's not nearly enough faculty positions or even non-faculty research staff positions to accommodate all the PhDs who graduate. The presumption is that most people who graduate will go into something other than academia. If you want to see the system failing, look to humanities, where most people who get a PhD are legitimately interested in academics and yet they will, in the best case, be stuck as terminal adjuncts
I've been trying to program myself out of a job for the last 25 years. I think I'm doing it wrong.
I think at some level in their heads there is an intent to convey some kind of meaning, but it doesn’t get through the layers of forming (correct) phonemes and grammatically sane phrases. It’s not like little kids don’t have thoughts and feelings before they’re able to articulate them, and merely create random noises, but more of a gradual process of learning to create those coherent and correct articulations.
Yeah there's no way to improve these people's lives without subjecting them to hours and hours of watching the worst content imaginable /s
Restricting governments from doing things is how legal rights work. That’s what legal rights are for - they are justifications that win in court, such as in a dispute with the government. And hopefully outside the courtroom too. So it does tell people “what their rights are.”
I don't, unfortunately. I'm trying to avoid having a dedicated backend for this so there are Google Analytics but they don't allow that granular of a metric.

That definitely could be something interesting, but I'd probably need a decently larger player base to get enough data, considering how many words are possible.
Thank you! Yes I did draw somw inspiration from bashcrawl as well. I didn't know about these types of games when I started using the shell. I'm hoping this can help a few new comers.
>Nor can anyone hear the difference between a 16bit and a 24bit file, all else being equal.

While we don't know the exact dynamic range of human hearing, we do know it to be above 96dB.

Either way, using these 96dB in 16bit requires careful mastering.

With CDs, it is not possible to e.g. make a song quieter than the others in the CD without losing this 96dB range. There's no "ReplayGain" metadata in the discs; the format is aged and not fancy at all.
The lines are arbitrary, but it may still be useful to draw them for some applications.

It’s a rainbow all the way back to the first tetrapod (and beyond). But clearly we are not fish, so somewhere in that spectrum there is a useful distinction to be made, a line to be drawn. Of course, the closer you get to finding that line, the faster it vanishes. It’s equally futile to say that we are indistinct from fish because there is no clear and decisive separator.
On a side note, it is also a critical dependency to safeguard that right in the first place.

A right to history and culture is also another dependency since people are functions of the culture they learn from their parents. The burning of books which destroys culture is universally accepted to be a bad thing, but its still done indirectly today (libraries budget is dependent on circulation metrics, classics may not be checked out often, books not circulated well get donated to third-parties who pulp, or resell and then pulp if not sold within a period of time.

Even Goodwill does this for content they deem is unsuitable, which is a value-based decision from some unstated individual.
Thanks and of course, I want it to be accessible to everyone.
Yup, that's a really good point. I kind of wish I had marked ambiguous words on a first pass, and then taken a bit of a different approach for a second pass of just the difficult ones.
As an aside, it's interesting to note that there is a hypothesis that one reason why humans, and most other species, do not regrow limbs is precisely as a means of protecting against cancer. The few species that are able to regenerate limbs usually have to activate the regeneration, and that activation involves turning on an immune surveillance system that seeks out potentially cancerous cells and kill them efficiently.
Unfortunately though this means the amount of people who can use it is dramatically reduced.
Fair enough man, my original comment was mostly in jest but I understand where you're coming from.
What haven’t software engineers fixed all the bugs?
This article is a good illustration of what's wrong with the current predominant approach in biology — it's all about genes and proteins, it's all way too reductionist to yield any meaningful higher-level outcomes. It's like trying to understand and manipulate an alien technology equivalent to a computer running a React web app, except you're only ever looking at and manipulating individual transistors in the CPU.

As Michael Levin said it, "reductionism is aptly named, it reduces what you can do". Do check out his research btw, it's some seriously impressive stuff. According to him, cancer, in particular, is simply a result of a group of cells electrically disconnecting from the surrounding tissue. He was able to force them to reconnect in one of his experiments, curing the tumor without killing anything.
> I tried improving my eye contact with ppl I meet like at grocery checkout or barista. However there’s usually like 3-4 foot distance which makes it easier.

Please, do society and yourself a favor and don't act like you perceive VCs to other people, especially people working to serve you as a JOB.

These people you are trying to mimick grew up interacting with people like you trying to get on their good side. That is what give them confidence. Put them inside a football pitch against good players and you will see a bunch of anxious amateurs that will not hold eye contact after being slide-tackled once.
I'm not conceding that rights are zero-sum. I'm trying to get to why you think people have the right to single sex spaces. What is the motivator for that belief and would that same motivator suggest that people have a right to segregation from other protected classes?

I think women have a right to safety. They have a right to privacy. They have a right to being given the same opportunities as anyone else. A girl has a right to compete in sports. She doesn't have a right to win at sports or even a guaranteed spot on the team. Those rights are not zero-sum. The rights of a cis girl are not violated when she competes against a trans girl.
Where are they now ?? Have they pledged for project 2025
So Peter Thiel is an idiot.

Biology especially human biology is a lot harder simply because experiments have bigger ethical issues.

Even if you have desperate cancer patients there are limits how and what you can test.

And we have others fields where all these brilliant people according to him are working and all the money goes and the problems are also not solved.
Also check out the opposite - YouTube videos that have almost zero previous views:

http://astronaut.io/
There are lots of Python libraries out there. There might be some with no Dart equivalent?

But if you don’t care about using them, maybe it’s not that compelling.
Tracking Fireworks Impact on Fourth of July AQI
> What are we gaining here that is worth such an enormous risk?

Well, Flet's landing page has a bunch of features and benefits. What is an "enormous risk" anyway? Depends on what you're doing. There are endless cases I can imagine where I just don't care at all about such a risk.
I sort of did; the motivation was the poor quality of business requirements, which I traced to the extremely false belief that a physical data model can capture a business process. Then the game was to try to cultivate information architecture, to understand the rationales for legacy data models, especially where they were not good enough, and eventually train how to deduce adequate data models from the processes. Long story short, no one understood.
The site's down for me, here's an Internet Archive link:

https://web.archive.org/web/20240706220437/https://marvinh.d...

I've really enjoyed this author's series on optimization techniques explored through non-trivial yet still small case studies, the other articles linked near the top are all worth checking out too!
Because of this unfortunate idea in our industry that any software product constantly needs new features and is never done.
> Besides, if the President declares that you must as an official act, alas you must or face the unmitigated consequences (according to recent rulings).

This is not accurate. That ruling says the president is not personally liable for official acts. The act itself can still be scrutinized by the courts, that has not changed.
"Consciousness" seems to be some sort of a reserved word somehow.

https://en.m.wikipedia.org/wiki/Reserved_word

"Flagged" article, wow that's unexpected.
That has nothing to do with this. Granular lock free tables will outperform global locking by orders of magnitude, but it has to be designed differently from the ground up.
I, of course, cannot provide medical advice, but I have had chronic migraines since I was a teenager. Over the years, I've identified several triggers and tend to categorize them; lack of sleep is common. Of course, a complete night of restlessness is fraught with many problems, but I can almost always guarantee that a migraine will be one of them.
Canadian government organizations and military also
Why would it bother you enough to write this essay if you know it’s not true?
Or far southern hemispheric; I stayed at my uncles last night on a makeshift bed in the living room,
He has a network of connected goldfish tanks (connected by water filled plastic tubes the fish can migrate through)
He has the whole thing on a seasonally adaptive sunrise / sunset lighting system. Mirroring that chesapeake bay ecosystem simulation in which the crabs migrated with the season, the fish move north and south following subtle temperature gradients during the year.
This morning I woke up to an amazing underwater sunrise filtered through undulating seaweed
As I opened my eyes to the cold winter morning (my uncle has no heater) in my sleeping bag and red wool beanie, I felt as if finally I had joined team zissou