skysight-inc/HackerNews huggingface dataset:
I’d argue it’s the opposite.

Look at what’s happened since Oxycontin was heavily regulated.

Opioid deaths in America have exploded by an order of magnitude.

There’s a direct correlation between higher regulation of OxyContin and opioid deaths in the U.S.

The Sacklers have done illegal stuff. Misrepresenting the addictiveness of their drugs (well, it was immoral and wrong…it’s not clear how illegal it was).

But it’s quite clear that America had a parallel opioid crisis going on. By making OxyContin easily available, ie, a slow acting opioid (it had to be crushed to be fast acting) that was produced legitimately and had a legitimate supply chain so people were able to get exactly what they wanted, Purdue Pharma helped keep the number of opioid deaths under control.

IOW, the U.S. has had an addiction crisis that is independent of prescription drugs whose cause is not clear yet because everyone has thrown the blame on Oxy instead of researching it. This is the same kind of drug crisis that hit inner cities in the 20th century but has hit rural areas in the 21st century. By providing easy access to regulated and legitimate opioids the Sacklers may have marginally worsened the addiction crisis, but they minimized the number of deaths and severe negative impacts.

The moment Oxy and the other opioids were made less easy to get, the underlying drug crisis hadn’t gone anywhere, so instead the people suffering from the crisis had to get their opioids from illicit sources as opposed to the pharmacy, exposing them to all sorts of unregulated drugs that had all sorts of nonsense like Fenranyl mixed in, which causes the actual negative impacts of the drug crisis to explode.

The funny thing is that when the entire country was just absolutely united at making the Sacklers the big bad evil, the actual people working on the ground trying to help those who were facing this drug crisis were predicting this exact situation and were asking authorities to not clamp down on Oxy. But they were all ignored and so we have a situation where opioid OD deaths have gone from a consistent 10-15,000/year (a rate which preceded Oxy) to about 50,000/yr now.
In my experience, modern optimising compilers can turn many naive loops into tail recursive loops.

Actually learning tail recursion and writing loops for it is a lot less necessary today than it was in the 1980s. It isn't necessary to teach it to beginners anymore because the compiler largely does the heavy lifting for us.

These days, tail recursion is a very advanced performance tuning trick, only used when you've positively identified your compiler version's implementation of your loop as the cause of slowness and you're willing to incur the increased code complexity for the increased performance.
Same, no blue light or eyestrain is a plus. I agree with the other child comment though, the price is too steep for now. FPS and it being Android and therefore extendable is great. I want one.
Rockset users scrambling to find a new real-time analytics home....

I'm putting together a public/free Rockset feature comparison matrix.

I want to help educate customers (and other vendors) on what Rockset did so well and what considerations are needed to find a replacement.

https://bit.ly/rockset-feature-comparison

HN'ers I realize you are wizards, don't shoot the messenger. Just trying to help.
? There's no other spacecraft there now with spare seats. NASA could arrange to send a Dragon up, but at a pretty fearsome cost. (Crew dragon missions are something like $300 million. There's one scheduled, and paid for, to launch fairly soon, but with no spare capacity -- if they wanted to use that for Butch and Suni's ride down, they'd need to bump two of the currently scheduled crew for that mission off.)
I don't care where papers are published (in fact I mostly agree with you, I think that the idea that research needs to be novel to everyone currently in the field is harmful and leads to gate-keeping, self-censorship and unpublished folklore). I am merely pointing out that appealing to the authority of PLDI as the premier PL research conference to qualify the paper as research does not work since PLDI did not publish it.
Under the bankruptcy settlement, Purdue will continue to sell opioids. The ownership will change (profits will be used to fund the causes you listed) but the operations will not. Right?
Saturating 100Mbps will move about 1TB/day.
It's sold by a Chinese company, their software probably doesn't worry much about optimal formatting, since Chinese writing doesn't really have any spaces. It would be nice if koreader could run on it.
Physician Empathy Beat Opioids and Surgery for Chronic Pain
Is a bakery obligated to sell sesame-free products?

If a bakery wants to limit their potential customers by saying their products may contain sesame to avoid liability, I don’t see why the FDA should step in and force them to take on liability and capital costs for sesame free factories.

If the FDA’s current allergen rules are leading to this outcome, perhaps it’s the FDA’s rules that are flawed.
Baccarat Lucky Butterfly $250.00 Purchased

Maybe not as lucky as advertised?
The specific answer to OP’s question is manoeuvring thrusters, a heat shield and a landing system.
>you don't seem to have actually taken or learned important parts regarding this subject matter.

If I hadn't mastered the concepts of computability and deterministic finite automata, I wouldn't've written what I did.
This is going to be hard to believe, but something that really helped me understand the diversity of what being "right" means is listening to old episodes of This American Life.

There are lots of stories about a normal person in an unusual situation who ends up behaving "strangely" or making decisions it's hard to understand, or there are stories about people in very normal situations who are just very unusual people.

Either way, you learn that everything is a shade of gray and certainty is the most likely way that someone can be wrong.
Well... the FDA won't allow companies to just list "may contain" for sesame, they have to have effectively multiple plants in complete isolation, or... add a tiny bit of sesame to everything and affirmatively state so.

In this case, I prefer the "may contain" verbiage... saying something "does not contain" is a practical minefield. If you're that sensitive to something, find a producer that makes what you're asking for, or if you can tolerate a small amount, or make your own food from basic ingredients.
I had the same experience. It was a bit awkward for 6 months, but down the line we learned to design better apis, and dealing with nullable values are tedious at best. Its just easier knowing that a string or integer will _never_ cause a nullpointer.
It seems that Croatian operators didn't get the memo about the discount.

Here the phones that you can get from your carrier and pay off on a monthly basis often end up costing more than in retail.
Don't forget McKinsey:

https://www.nytimes.com/2021/02/03/business/mckinsey-opioids...
The Supreme Court reversed another triumph of political judgements - the indemnity of the Sacklers - so unfortunately, things seem to be trending away from pragmatic, politically driven solutions to problems and more towards the RNG of the Supreme Court.

The US is basically governed by playing Yogg-Saron now, and Clarence Thomas is the premium illustration.
Interesting read.

I come from a C64 origin, cracking games and writing crack intros, where I’d use sprite multiplexing to do top and bottom border sprite scrollers. You could do side borders too if you timed it correctly.

Either there were sprites moved or textual data rotated through an array of sprites.

Arcade games would often use a similar approach of multiplexing to do attack waves of baddies moving along the x-axis. Obviously, they were constrained in y-axis.
They take the security of their cash flow very seriously. Which is partly why the anti-regulation vibe in Silicon Valley bums me out so much. The writing is literally on the wall here.
Companies aren't dogs, companies have obligations that they need to fulfill and they're choosing to neglect them.
AI Governance Framework
There is a proposed standard for AI governance from an accounting/regulatory perspective.

Note that the last time someone proposed something called COSO it was little known and few people did anything with it, then there was enron and a law requiring a framework for controls. Therefore, this is likely going to stay fairly obscure unless a regulatory catalyst occurs.
Ive had the luck of recently having effort rewarded with fair raises. But can see how most companies won't do that
Feature flags are great for safely releasing features fast.

As you add more of them though, they add tech debt and make the code harder to reason about. Developers are rarely motivated to clean them up after rollout.
Obama briefly pitched the idea of this. A lot of people worried that the government providing services with the ability to verify identities would kill anomenlty online and it died.
Makes me wonder what is the half-life of space debris.
Alibaba Cloud reveals its datacenter design used for LLM training
Just the founder of CircleCI listing some uncomfortable facts such that you instinctively derive the best resolution to it.
Recently there was mass infringement by the Democrat politicians or government reps of our 1st Amendment rights indirectly through social media as proven by the #TwitterFiles.

The fact that these sites are now forcing users to submit to these identity disclosures simply because of some potentially fabricated rationale is really concerning.

All of that with the nonchalant attitude of these data service providers, I'm deeply concerned.
Yeah, I think it's best to first rethink of null as just, not 0 and not any other number. What that means depends on the context.

Tangent: I've seen an antipattern of using enums to describe the "type" of some polymorphic object instead of just using a oneof with type-specific fields. Which gets even worse if you later decide something fits multiple types.
> a government-run identity service.

Sponsored and standardized, maybe, /run/ definitely not.

These entities love creating things like "No Fly Lists" I can only imagine what their greedy little hands would do with the authority to strip one of the ability prove their identity.
Over-extending yourself can lead to burnout. Pacing yourself and not becoming a problem is good for both the employer and employee.
Wasn't Oxycontin kind of the boot loader for the present opioid crisis in that it mainstreamed opioid use and got a huge number of people introduced to it?

Then it was taken away and things like illicit fentanyl filled the gap, but that came later.
More background:

TeamViewer's corporate network was breached in alleged APT hack https://www.bleepingcomputer.com/news/security/teamviewers-c...
IRC is not mobile-friendly (and I have to regretfully admit we live in a push-notification-requiring sort of world now).

Myself, I needed something IRC-like, which was open-source, and mobile friendly, so I tried Mattermost team server for a few years. What turned me off over time was that it required manual upgrades. I would have preferred something which was a nice, tidy Debian package.

Now I've turned to the prosody XMPP server instead, which is a standard Debian package (and now upgrades itself, if and only if, there are security problems, with Debian's "unattended-upgrades"). It runs on a $5US/month VPS. Setting up all the SSL stuff, and firewalling rules - as it uses multiple ports - did take a few days to figure out!

PS: A similar discussion around merits/demerits of IRC was recently on mastodon here: https://hachyderm.io/@miah/112649146585492861

I made a couple of related comments (WRT prosody, and Mattermost Team server):
https://c.im/@sbb/112673859554591548
https://c.im/@sbb/112673727757562126
As someone who can't eat gluten, we look for that label because gluten isn't included as one of the mandatory allergens in the US. I would prefer if things were simply labelled as "contains gluten" because instead I have to evaluate the ingredients of things without a GF label to see if it's suitable.
Doesn't macOS have a built-in VNC server?
The URL is likely used from within Apple frameworks for various purposes, and therefore it's possible for an app process to open the URL even without the app itself knowing about the URL.
Maybe this is why all these breads use such a large list of ingredients that don't sound like food.
C can essentially do the same thing. I do not see why C++ would have a fundamental advantage here.
You aren’t addresing the problem posed by the grandparent comment.

You say we should be more on the cautious side. Sure, that’s a fine take. But without actual classification as to what counts as “ultra-processed” food that actually maps to harm in some way, you end up with the California-style “potential carcinogen” sticker warning slapped on almost everything. Which is useless at best.
Haha. I wonder what my desktop environment falls under (i3, rofi, polybar)
There's this summation notation that these people who see programming as math and get excited about recursion forget about too.
In general in the USA a lot of things are pushed to you as monthly payments, and not the total cost of ownership.

Yes, you can afford a $900 / month car note. But that doesn't mean that it actually makes sense to pay it for 72 months at some ridiculous interest rate.
I don’t trust Whatsapp. I’d rather book directly with the service I’m booking with.
If I were to buy that John Deere, I would expect a 20-30 year lifespan with just normal maintenance.

If I were to buy that Ego T6, I expect that it would be unserviceable e-waste within 5 years, or less.
Purdue aggressively marketed OxyContin as having a very small rate of addiction to doctors who weren't pain specialists and thus had little experience with controlled medications, while providing a dosing regime that was almost designed to cause addiction. (It's sole advantage was as a timed-release medication; if pain returned before time for the next dose, doctors were instructed (strongly) to raise the dosage rather than increase the number of doses per day.)

"The Promotion and Marketing of OxyContin: Commercial Triumph, Public Health Tragedy" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2622774/)

"The Family That Built an Empire of Pain" (https://www.newyorker.com/magazine/2017/10/30/the-family-tha...)
I suppose we have different definitions of harm. Providing a product which might contain an allergen and notifying you of that possibility is not harm in my book.
Why does urllib have this URL scheme anyway? If Python libraries are hard-coding knowledge about Apple proprietary stuff, then it should be no surprise that Apple may take issue with that.
I understand two answers to your question:

1. Nothing will replace the opioids, but we should make most routine use illegal anyway, because the usage you described causes addiction, abuse, and death in some cases, which overrules your QOL improvements.

2. Nothing could replace the opioids, so we should keep the status quo. The addiction, abuse, and death are a relatively minor downside to an important bundle of benefits. The Sacklers marketed them illegally, but we've course-corrected as best as possible, and the new status quo is uncomfortable but OK.

These are, I think, the first two buckets of people I listed. I understand them both. I think you're in the second camp. I'm in the first. But I think most commenters here are in neither camp???
He was at the top all along. He's one of the founders.
They should do a whole lot more then! Ideally they'd have effective impact.
It's a busy mess on GCP. If they wanted to compete well, they should do much better with UX design, especially for onboarding. Compare how easy setting up a Mistral account is with GCP to do some generative LLM in a Python script. GCP is a maze. Did you make an account to reply to this? I'm curious what you do with GCP? Are you a heavy user?
Wedding Party coming soon!

I bet $15 on 'nope'
First pair of Pandas to enter the United States in 21 years takes off from China
Can't they send up one of the space x ones?
I don't know, cinnamon bread french toast with sauteed apricots and cockroaches is a mix of carbs, fiber and protein, though probably should have more protein for a better nutritional balance.
> Total fraud in that case was $900 million, for a only 500 patients, or almost $2M per patient.

That seems so outside the bounds of reality that I'm questioning if it's what happened here. I can't imagine how that would pass any kind of sniff test by Medicare.

Quote from the article: "In less than two years, more than $900 million in bogus claims were submitted to Medicare for grafts that were used on fewer than 500 patients, prosecutors said."

The alternative interpretation of this is that the grafts were _applied_ to 500 patients, but potentially many many more were billed for grafts that they didn't need (and didn't receive). Maybe more feasible?
This level of fraud is almost non-existent when there is NO insurance and NO universal healthcare.

Anytime the person paying is not the one receiving service, the appeal of fraud goes up. When the person paying is not paying with their own money the appeal goes up and a TON of incentives argue against finding fraud. At least in govt, there is sometimes a willful blind eye because finding fraud causes a huge headache and you don't benefit or get paid more. In fact, if you are taking an administrative fee to manage the program, reducing expenditures can hurt your own budget.

I have traveled internationally where folks paid cash for services. It was a bit crazy - they would basically hold you hostage until you paid a bill / impound your car etc. BUT you could buy many drugs OTC (no DR visit even required) and the layers of things like approvals, pre-approvals, billing and billing codes etc simply didn't exist.
I'm not sure if this is strawman or motte-and-bailey (leaning towards the latter), but you are continuing to ignore the group of people we're talking about and are instead only referring to a different and much easier to defend group that we're not talking about.
> The higher the altitude, the longer the orbital debris will typically remain in Earth orbit. Debris left in orbits below 600 km normally fall back to Earth within several years. At altitudes of 800 km, the time for orbital decay is often measured in centuries. Above 1,000 km, orbital debris will normally continue circling the Earth for a thousand years or more.

https://orbitaldebris.jsc.nasa.gov/faq/
The Samaritans https://en.m.wikipedia.org/wiki/Samaritan_Pentateuch preserved the Paleo-Hebrew version. https://www.tabletmag.com/sections/belief/articles/the-other...
They added the cockroaches to get the protein count up.
Sure, OxyContin is better than Fentanyl, and banning Oxy can push people to way more dangerous opioids. But before painting Purdue as a hero of the people, let’s remember that million of people were pushed to opioids through Oxy when they shouldn’t have in the first place. Purdue played a big part in creating the epidemic in the first place. People that are now pushed to harder drugs because of an addiction they got into for the sake of Purdue making more dough.
> penalizing secular tech entrepreneurs

"If you kept the small rules [like secularism], you could break the big ones [like occupation]."
Yes, but not necessarily enough for the error to cross pixel boundaries, or at least more than a pixel. So while incorrect, it would be hardly, if at all, noticed.
There's one scheduled, and paid for, to launch fairly soon, but with no spare capacity

Stupid question of the day, can we not just force jam a bunch of astronauts into it?
Because car manufacturers exist, and this isn't theoretical or a jab at cars themselves. We are 100% certain that people will die while using cars, and by cars. Vehicular manslaughter even has a high bar for real punishment precisely because driving a car has an inherent risk of killing others and that risk is legal to take on.

Knowing that some people using your product will die, and even that selling more of your product increases the deaths is something we're okay with. It's true of guns, red meat, skateboards, alcohol, lawn mowers, and industrial equipment — all sold for profit.

I very much dislike cases like this because while yes, opioids were overprescribed and Purdue sales people did go out and sell often times not in legal ways, doctors still prescribed them and we knew that people dying was necessarily an outcome. So while the crime they actually committed was about kickbacks, not doing the DEAs job enough for them, and lying with statistics they get blamed for the actual deaths which is silly. I take stimulants that double my risk of heart attack and are also known to be addictive, neither outcome is the maker's fault if those happen. It's the tobacco settlement all over again where when bad thing happens the proximate deepest pockets get blamed. I couldn't care less about the government taking money from rich people because reasons, have at it, but I think they're the scapegoat.
> I am merely pointing out that appealing to the authority of PLDI as the premier PL research conference to qualify the paper as research

I wasn't actually - I was pointing out the contradiction in supporting gatekeeping and then the second-guessing the gatekeepers.
Shipping containers are another genius-level invention - even better than wheels on luggage.

They used individual crates before!
Some of the details inside protobuf in Java can be very convoluted, but they are also the result of intense benchmarking, years of experiences and a long tail with deep legacy support for old java.

Honestly I found the Java bindings to be way better designed and thought out than Golang. On a consumer level, the immutable message builders are fantastic, the one-ofs are decent compared to what Java can offer, and the service bindings actually provide a beautiful abstraction with their 0-1-many model. In Golang, if you only have to deal with Unary rpc they are OK I guess, but I really miss the immutable messages.
username "addicted" eh?
Rather typical in Germany (they usually do it via Schufa, but the end result is the same). No idea for other countries.
I am salty that there is not a single library that is so good and well established that we could simply vote it into the standard.
And what is the FDA definition of "reasonable" that will keep the ambulance chasers away from their businesses?
I have read 'How to disappear', i don't think it would be very useful here. It's written by two private detectives to help people evade stalkers or family violence. It specifically recommends against breaking the law. In any case it would be a bit out of date by now.
Using recursion for loops then letting the compiler work out that it's not actually recursion and it actually a loop is more for people caught up in the pageantry of programming than people who want to make programs run.
This on the other hand I like, very much!

Particularly:

> Also, in general it seems unlikely humans function as optimizers natively, because optimization tends to require drastically narrowing and quantifying your objectives. I would guess that if they're describable and consistent, most human utility functions look more like noisy prioritized sets of satisfaction criteria than the kind of objectives we can train a neural network against

Considering this, what do you think us humans are actually up to, here on HN and in general? It seems clear that we are up to something, but what might it be?
Evaluators with CriticGPT outperform those without 60% of the time.

So, slightly better than random chance. I guess a win is a win but I would have thought this would be higher. I'd kind have assume that just asking GPT itself if it's sure would be this kind of lift.
Plenty of people use IRC on mobile, not sure what you mean by "not friendly"...
No, my question is about how people judge our opioid status quo: a medical system that prescribes addictive opioids for routine and low-grade pain.