skysight-inc/HackerNews huggingface dataset:
> Potentially, antibodies, as a functional category of therapeutic, may very well be on their way out.

I’m a bit confused as to what you reference here but I’m assuming monoclonal (mAbs). I apologize I did not read your prior post. The market estimates are quite optimistic in this category such as:

> Antibodies are the dominant class of protein therapeutics with over 160 antibody therapeutics currently licensed globally and a market value expected to reach $445 billion in the next five years

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10983868/

Are you aware that BARDA is investing $5 billion into therapeutics like monoclonals/polyclonal for COVID-19 countermeasures? Their major focus is on many of the problems you stated and they want to drive costs down:

https://youtu.be/t9lrPDxLsfw?si=T87jPBinbuTtDad_

Monoclonal antibodies seem like they finally are reaching the golden age based on their use earlier this pandemic, novel findings for rejuvenating our immune system, and even targeting other notable chronic diseases.

https://medicalcountermeasures.gov/nextgen/

https://www.nih.gov/news-events/nih-research-matters/rejuven...

https://www.nih.gov/news-events/news-releases/nih-scientists...

The primer in the next generation is wonderful. I’d love to see nanobodies created for SCV2 as soon as possible. The interesting part is that these platforms that BARDA are helping get online will help us pivot to any threats and use these next generation vehicles to respond. Keep an eye on vaccines too as they are going through a moment of next generation vehicles as well. I.e. multiple antigens, mucosal deliver, etc.
So I'm sure some adaptive cruise controls are better than others but coming from a BMW X5, the range of the sensors would result in situations where traffic would speed up, a car in front of me would change lanes, adaptive cruise is set to 65 mph (because we're on the highway, even if we're crawling along) so it speeds up because it thinks it's now "open road" but the cars in front of me are already slowing down because of another bottleneck ahead so it has to slow down quickly once it detects them.
"Some people might say it’s a bit like Lua with Python syntax"

ye gods
There’s a really interesting angle about how the model of the service fits with the user’s concept and consent here. Apple Photos only indexes things you choose to save there, and you have to grant access to other things like Siri using it, and most people seem to be comfortable with that because it’s easy to understand the scope and opt-out.

Recall is the opposite: on by default and it records everything, which leaves people uncertain about whether they even can reliably opt-out or what that will mean if they’re interacting with someone who hasn’t, and combines with other areas of Windows 11 where Microsoft has been doing things like putting ads in the start menu which really cut into users’ trust. The blowback has been pretty impressive for what might otherwise have been a relatively ignored feature.
>I confirmed this via an AI facial recognition search engine.

Lol! You just put the more information of yourselves online by that one action than 1,000 happy snaps on Facebook would have.

There is some irony in knowing enough not to put your photos online but not knowing enough as to feed it the most key information for your identity possible.

"But they won't use this information!", nope. They will. "But it can't be tied back to me.", yep. It can.
I like the idea of Evangelion where there is three AIs with different priorities voting for decisions.
How is that operationalized?
Super interesting writeup, thank you!

So I know there's a difference between humanized and fully human mAbs, but is the manufacturing process identical between them? Do even human antibodies grow in CHO tanks?
I know what you mean, now that I can afford the car of my dreams, it's not my dream anymore lol. Just missed it by about 10 years.
> Conceptually, any information created or consumed outside your organization is not valid as part of a surrogate key, so SSNs are not a surrogate key.

SSNs are created within the organization. Maybe not within your organization, but nobody is talking about you. They are a surrogate key.
Everybody, in fact, takes innumerable social parameters into consideration when you say anything, especially with strangers.

For the sake of mass communication where you can’t really know your receiver, you have to do your best to just communicate whatever you need to (i.e. ‘a single approach’). Choosing to use a word that is ambiguous as to whether it is a slur is a bit unwise. I think it is probably unwise to do the same in personal interactions.
Real-world problem, likely related to what you do. Simulate day-to-day problems. E.g. you are a marketplace business, ask them to do a simple basket system, or a checkout or a product catalogue etc. Ask them to review some code and provide their analysis.

FWIW I think LeetCode problems can make sense for some businesses, but most not.
This one has an (optional?) 2000W sound system to annoy ground crew and make enemies of the neighbors.
What’s the privacy nightmare? That the cars have cameras?

Do you also think it’s a privacy nightmare when you step into an elevator with cameras? Walk into a building with cameras?

> InB4 “akshully you have no right to privacy in public” — you should, and those laws predate ubiquitous cameras in every pocket, on every doorbell, and rolling down every street.

Surveillance cameras have been ubiquitous for a decade and the laws have been updated in many countries around that fact. Cameras in public spaces are not a new invention.

If you’re trying to suggest that we should ban cameras in public spaces then you’re never going to be happy with reality.
> one day we can all integrate the support for GSO that's been landing in gvisor

Google engs recently rewrote the GSO bit, but unlike Tailscale, it is only for TCP, though.

Besides, gvisor has had "software" & "hardware" GSO support for as long as I can remember.
Yes and that's the problem. I think you should be completely focused on the road with full attention, not half zoning out until your Tesla randomly swerves into some innocent bystander. I don't trust that you'll react in time.
Gosh I don't even keep both hands on the wheel (especially not in gridlock) in my car that's old enough to get a license to drive itself (ironic, given the article).
Old but Gold: JsDelivr May 2023 Outage Postmortem
It’s not soldered, but it does have a Molex Pico-EZmate connector (chosen for its low profile), and I’m not sure you can find batteries premade with that kind of connector. You could reuse the existing connector with a new battery, but that would ideally involve soldering.
But surely it isn't wiggling the tissues by sound waves passing through matter, but by vibrating space time itself?

The skull shouldn't be able to resist gravity waves any more than soft tissues or 10km of lead?
if I could be a researcher, this would be one of my main topics. I have personal reasons to be interested in languages with alphabets that have "very special symbols" such as the parenthesis.

in general, i'm curious about how as you progress up the type language hierarchy it becomes necessary to keep adding specialized symbols to keep up. most interestingly, i wonder about how one pair of symbols (open and close) add a lot of expressive power but I suspect adding more different types of pairs of symbols won't significantly augment the expressiveness but I don't know for sure.

this is also reminiscent of dyck languages and their corresponding automata, which can recognize and match open and closing parenthesis. I did not know visibly push down was sufficient to recognize parenthesis, I thought a stack was sufficient. but given a stack is more powerful than the unidirectional "stack" of a VPLs it all makes sense
> the gravitational wave strain would create audible-frequency artifacts

Pretty sure this is only true if the spaceship (or the disturbance it causes) is ~100 miles across, like neutron stars and black holes are. If it’s much bigger or smaller, the frequencies will be shifted correspondingly shifted.
> like the fact that libel and slander are illegal, despite that seeming to me as a pretty direct contradiction to the First Amendment.

Libel and slander are civil torts. The First Amendment only applies to the government.

You cannot, in general, be sued for libel or slander if the quasi-victim is the government, or a government official. You're free to call politicians every nasty name in the book and they can't do much about it. That's what the First Amendment is about.
I think they just like cheaper land and labor costs.
This is a kind of "false dichotomy". Not using single-letter variable name doesn't ncessarily mean using long verbose variable name. A variable name can be one word or two words that explains well while not using much space. Things usually need balance instead of extreme.
These researchers are being recruited regardless of what license they put on their academic code. In fact, I really doubt anyone in the industry cares about the license for this work. It's not a patent.
More money is spent/made made on iOS gaming than on traditional PC gaming, even if the $60 up front model isn't something iOS users are willing to accept. I almost think they're right to tolerate mtx models btw. At least if games are f2p, companies aren't releasing them broken/unfinished.
Why is taking photos with butts and cleavage in the picture illegal but not taking photos of someone?

"Clearly illegal"? How? What's the difference?
I don’t know about that. Cruise tried to move too quickly in an attempt to catch up to Waymo and accumulated a ton of much publicized issues in SF. Constant stalling in intersections, involved in a few collisions, etc. CA DMV clearly noted “performance issues” as one of the reasons for their suspension.
Even Hardened Convicts Are No Match for These Guard Geese
I can’t even swap control and caps lock because I can’t control all the keyboards in my life. Somehow, somewhere.. someone made this choice for all of us and none of us can unmake/correct it.

My pinky finger is angry.
Sorry I hyperfocused on the value but it's really the context which makes it confusing:

> 10^-7, that is, 4 times 10^-17 times larger than the gravitational wave detected

which doesn't sound right. (Like saying "X is 0.1 times larger than Y" when X = 10Y.) The ear displacement is 2.5×10^16 larger than the gravitational wave, no?

(Also I think 10^-7 should be 10^-5 in the quoted phrase, as per your reply above.)
True. FSD works anywhere while Waymo works in a few square miles.
Out of interest as I have found IPv6 RA to work flawlessly for my home network (alongside legacy IPv4 DHCP), what advantage (if any) is there in deploying DHCPv6 within the home LAN? Or were you meaning to say DHCPv6 is great for certain (enterprise?) use cases?
In the old days, moderators were encouraged to update the old post. Many stopped to do that when people complain their post were edited by others, or the votes goes to wrong person because it was edited.
I am the founder of randonautica, so in short yes I have found that our universe is more than random. Thanks for the answer, sometimes I wish a little more intuition was allowed here rather than only analytics.
You're confusing device-specific APIs with OS-specific APIs. There's a big difference. DX11, DX12, Metal, etc. are themselves all abstraction layers over what are in some cases very different hardware designs. (This will eventually become less so with Apple moving to in-house GPUs, but for now it's still true--Metal targets NVIDIA and AMD GPUs as well as Apple's M1/M2s.)

Maybe it'd be interesting to contemplate a world in which red team, green team, and blue team all have their own proprietary APIs and there are no cross-vendor abstractions, but that's not what we're discussing here.
Location: Vancouver, Canada

Remote: Yes

Onsite/Hybrid: Yes

Willing to Relocate: No

Languages/Frameworks: JavaScript, TypeScript, Vue, React (classes and hooks), Node, Angular.js 1.x, Swift, SwiftUI, Python Tooling: Vite, Webpack, Github Actions, Docker, Jira

Résumé/CV: https://drive.google.com/file/d/13U3znCOGAdBZgjCfkjt30fqXRlZ...

Email: luke (at) luketully (dot) ca

Previously: Worked on the frontend team at JLL Technologies inc, formerly Envio Systems, on feature improvement and on a big refactoring push from Angular 1.x to React/Typescript/Redux/Jest. We were responsible for a commercial building management product, and the team was distributed across the EU, NA, and Asia, while I worked remotely from Vancouver before getting laid off in early 2023.

Currently: Have spent my time learning Swift, SwiftUI while building out a native macOS app, building up my low-level knowledge through the Nand2Tetris course, and learning Nuxt + Django + Tailwind to strengthen my full-stack skills. I have about 8-10 years of experience depending how you count it, but it's fragmented and I'm just looking to do some decent work over the short or long term, FTE or contract, happy to discuss options. I'd be open to both intermediate and senior roles, and am very adaptable.

Goal: I'm based out of Vancouver, but happy to discuss different remote arrangements globally or hybrid in Canada. I enjoy working on sticky legacy problems, improving UX and DX, and making useful products with a good team.
Realistically 20-30% more if you pack for example a yogurt into glass instead of plastic.
Glass would be like half of net weight.
https://martinwecke.de/108/#A4B014C4D2F01H23J013L23N01O4P2

hell ya this is awesome.
Late to this... but elevated ALT/AST levels is canonical observation of obese patients or patients with unhealthy diet.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659656/

Alcohol is definitely a confounding factor here but this documentary is more of a "social experiment" rather than a proper study.

It's patient sample size (n=1) and doctor (n=1). IIRC, the 2 other doctors MS consulted (cardiologist and a gastroenterologist) didn't mention the same opinion as the internal med doctor and the doctor who did voice the skepticism was also saying it shouldn't be a no brainer that eating Mcdonalds would cause health problems. Other doctors on the web have gone on record to say "this makes sense."

Obviously it doesn't absolve MS of unethical filmmaking practices but that doesn't mean the premise is false given the plethora of other medical literature that supports it.
> the only feasible explanation is that Apple is hoping to somehow force developers into using Metal natively

I'm told the problem is some legal spat between Apple and Khronos that has led to a "no Khronos standards anywhere at Apple" policy. I don't know the details beyond that.
Oh. Well, silly me. I did double check that it's inverse-square, but apparently not deeply enough - the energy is, but the amplitude isn't. Which makes sense if I think about it a little more (it's basically a spring, so energy ~ displacement^2)

For other readers, this poster's correction is right, here's an astronomy SA thread on it. https://astronomy.stackexchange.com/questions/34761/why-does...

I swear, the one time I try posting outside my areas of expertise :D
The facts seem kind of light here. Sounds like Boeing essentially did further "due diligence" using privileged information, decided the whole concept wasn't viable and wasn't afraid to share that information.

Given that buying companies is the only way such a calcified company can expand its product base, you'd expect them to be better at it...
Sure is. Nvidia buyers right now couldn’t be buying any higher though, and they’re still buying. I get a feeling like the shorting opportunities will be apparent when they present themselves. I’m not looking to put my house on shorting it down any time soon though, but I’ll be surprised if there isn’t some big corrections and market pain in the next 12 months the way this is going. And if not 12 months, then the results day where Jensen doesn’t report a beat-the-street record quarter is going to be a bad day for the price, whenever that day comes.
I have no clue what your comment and the parent comment are saying
As someone who has lived in the Northeast US for most of my life (except for a stint in LA and SF), someone who has only lived in the two Waymo markets has no idea that they are playing the driving video game on the easiest mode possible. Almost no rain, it never snows, there's never any ice on the road, there are very few potholes, and the worst weather condition is some fog during which the Waymos can hide out in parking lots. At the same time, the pedestrians and other drivers are also relatively polite and concerned about their own survival.

Also, respectfully, most people who live in CA have very little idea about the mechanics of how to drive a car - they never had to learn because of the lack of the aforementioned precipitation - so it's actually a lot easier for Waymo to get to the same level as you because you are all bad drivers (mechanically, not in terms of politeness or rule-following). In CA I frequently got asked whether I ever did amateur racing or go-karting as a child, and when I learned that this was about how I handled a car (at first I thought it was just an odd inquiry about a specific hobby), I politely informed them that I did not, but I learned to drive in an icy version of hell.

I am hopeful, but it's going to be a long slog, and at the pace it took Waymos to become average-to-below-average drivers in SF, I assume it will be 10+ years before self-driving cars come to my area in a serious way.
What if the real purpose was not simply the function of Microsoft's Recall to run AI on snapshots and create functionality for the end-users, but to train AI on how to perform the most common functions of the average employee? Point being that it is not likely they developed this as a feature to entice end-users at all, and the other purposes are more sinister and invasive, unless one can stop the ex filtration of data usage back to Microsoft.
I love that idea, purchases could be equivalent of commits. LOL
It stands for Retrieval Augmented Generation. It is the trick where you answer questions that are not in the model's original training data by first running a search For documents relevant to their question, and then invisibly pasting there results into the model as part of the prompt along with their question.

It's the trick used by ChatGPT Browsing mode and Bing and Perplexity and Google Gemini and the new Google Search.
720x350 for the pervasive 80x25 text mode actually (a resolution which wasn’t commonly used at that time for graphics modes otherwise).

I’ve mentioned in another comment what I think may be missing for it to look right.

And I’m not really being nitpicky I think. It really evokes rather little about what this era looked like with “just” the right pixels at the right place.
Dexcom G7 now lets you monitor real-time blood sugar on the Apple Watch
"monopoly/cartel pricing" is a different phenomenon from "supply and demand"

It's not market failure, which refers to mutually beneficial transactions not happening.

monpoly/cartel power vs competition is what moves the price along the the axist between "cost to produce" and "value to consumer"
The only way I can see that happening is with an EEE model. You'd go grab all of the non-steam publishers and come up with a standard format that'd mean that studios can push to every platform in a standardized way, then bank on nobody bothering to install steam because the app store already has all of the games you want, and it's installed by default.
Yeah, this works fine unless you’re using something like DynamoDB or any system which requires you to have knowledge of the key.

For relational setups this is the way to go though. I prefer the combo approach though - autoincrementing numbers plus a UUID in another column.
The Sea… where EVERYONE can hear you scream.

(Unless you use radio to scream—it’s Space, on Opposite Day!)
What's your favorite primer on tcpdump syntax? I don't know why, but I always have to go back to my notes for anything even mildly complex.
It's worth keeping in mind that most production k code tends to be short, like even just a few dozen lines. It's not an application programming language and you are typically not modelling business rules. Most of the code is math-adjacent, and there may not even be any clear descriptive name for the variables involved.

The point is basically to put more code on the screen, so that you can think about what the code itself does, and basically maximize expressivity.

I do personally think Arthur is taking it a bit far, and it's turned into code colf for the sake of it, but at the same time, I don't think the idea is entirely without merit, at least in some circumstances.
"supply and demand" is price's effect on supply and demand, not supply and demand's effect on prices.

https://www.investopedia.com/terms/l/law-of-supply-demand.as...
I don't know how long you have been in HN, but I would recommend you familiarise with / refresh yourself on the community guidelines (https://news.ycombinator.com/newsguidelines.html). While HN looks and works similar to Reddit (and other such online communities), the tone and culture is not the same.
It's not like Windows is any less haphazard (if not more)! I think you'd be stunned by the OOTB experience of distros meant for newcomers （Fedora or Vanilla come to mind).
Harvard makes the news. Sadly it happens everywhere [1]

[1] https://www.nature.com/articles/d41586-023-03974-8 (apologies of you don't have access to Nature)
> "But, is it against the rules to directly post archive.is links of pay walled articles on HN?"

It is discouraged in the guidelines. But you can also post a paywall bypass in the comments of your own submission if you would like.

> "Please submit the original source. If a post reports on something found on another site, submit the latter."

https://news.ycombinator.com/newsguidelines.html

> "Don't wait for someone to post the link, just go to archive.is and paste the NYT link there yourself."

Yes and also paste the link back in the thread for other readers! I see it as sort of maintaining the commons, a very simple courtesy to others. You spend two extra clicks yourself to save hundreds or thousands of clicks for others.
It's distributed in the very few places where the future is very easy to build.
OT. A former neighbor has been a pilot for Air Tractor for decades ferrying planes from their factory in Olney, Texas to buyers all over the world. He's flown every type of plane that they've built over the years. Air Tractor has always had an excellent product.
Show HN: I made a movies recommendation app based on your mood
How many cars have you given the world?
Gato GraphQL v2.4: Support for Application Passwords and WP Multisite
during a war against an existential threat, propaganda is not unethical, its a duty and is to be expected.

i dont know of a single country that wouldnt do the same in their position.
An even bigger issue is educating people that plastics (that can be recycled) can only ever be recycled once and not over and over again like glass and tin.

https://www.plasticexpert.co.uk/how-many-times-can-plastic-b...

Once they know that they can decide for themselves if it’s ok for their take away food container to end up as a park bench at best.
The correct solution from a shipping company is not to engage with google.

Instead start a spreadsheet with all the people who worked on this product, and contact them as soon as Google announces it is shutting the API down. Or you notice a few people chaining their Linkedin status.
I'm not accusing him of anything, I'm just saying he's one of two known cases. I don't personally consider it a problem and I wouldn't care if he hadn't renounced it.
I never felt before that I am wasting brain cells as much as when I have to do something in bazel. The hermecicity thing it does relatively well but god does the documentation suck, at some point you can only get farther if you just read the java code implementing it...
Disagree; consider enshittification; that process embodies the essence of focusing on return vs product.