skysight-inc/HackerNews huggingface dataset:
I think it's fair at this point to say there is a clear relationship. The earliest article I have in my (relatively cursory) research file on the metabolic relationship for AD is from 1994:

Fukuyama, Hidenao, Masafumi Ogawa, Hiroshi Yamauchi, Shinya Yamaguchi, Jun Kimura, Yoshiaru Yonekura, and Junji Konishi. “Altered Cerebral Energy Metabolism in Alzheimer’s Disease: A PET Study.” Journal of Nuclear Medicine 35, no. 1 (January 1, 1994): 1–6.

Here are some more recent reviews discussing the connection (recent reviews are good not just because they take into account the latest developments, but they also give you better references to go through for further research). Note, these reviews are from completely different/unrelated research teams from different countries:

Yoon, Ji Hye, JooHyun Hwang, Sung Un Son, Junhyuk Choi, Seung-Won You, Hyunwoo Park, Seung-Yun Cha, and Sungho Maeng. “How Can Insulin Resistance Cause Alzheimer’s Disease?” International Journal of Molecular Sciences 24, no. 4 (February 9, 2023): 3506. https://doi.org/10.3390/ijms24043506.

Rhea, Elizabeth M., Manon Leclerc, Hussein N. Yassine, Ana W. Capuano, Han Tong, Vladislav A. Petyuk, Shannon L. Macauley, et al. “State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer’s Disease.” Aging and Disease, August 17, 2023, 0. https://doi.org/10.14336/AD.2023.0814.

Kshirsagar, Viplav, Chetan Thingore, and Archana Juvekar. “Insulin Resistance: A Connecting Link between Alzheimer’s Disease and Metabolic Disorder.” Metabolic Brain Disease 36, no. 1 (January 2021): 67–83. https://doi.org/10.1007/s11011-020-00622-2.
There's certainly a system behind the scenes on twitter accounting for links-- I have many times your followers (80k)since I have abused the system (mostly though giveaways from my sponsor) my links often get many times fewer than hundreds of likes and tens of retweets.

You can experiment with the no link vs link thing for yourself by putting the link it a followup reply like some news accounts do btw.
Cloudflare doesn’t block any ip addresses. Its their customers that do
Persia? What about China? I don't think there is any evidence of any contact between bronze age Greece and Persia.
Do we really have to go over the history of ideas that were once considered falsehoods but are now accepted as truth?

Your argument rests on the presumption that we have some kind of Oracle that can divine true information from false.

> rooted out and treated like the cancer you're choosing to be

It's cool that you think humans have changed in nature significantly from the time of the Inquisitions, but when you speak like this about people it's pretty clear we haven't.
Premium customer since 2013. Spotify would only give a refund in the form of Spotify Premium credits. And ironically canceled my subscription in the process of giving me the credit. SMH. Likely will GitHub Actions export my playlists and let the subscription expire.

I feel Spotify is really losing sight of its core competencies and its actual value proposition at this point. Will be interesting to see how this shakes out.

Spotify was amazing in recent years for 3 reasons:
1. Early pioneers in good ML based music taste making aided by teams of people who knew the various genres.

2. Spotify’s ability to do this well came from its strong investment in metadata which gave them a corpus of insight into what people listen to and why. Somewhat analogous to the rich tagging TikTok does to its videos on support of FYP.

3. The ubiquitous and continuous client support made it so easy to bring Spotify everywhere, that any alternative was going to mean more friction. In a way Spotify Connect is their iMessage blue bubbles moat. The ubiquitous and branded clients available on tons of hardware and every OS was their social contract. It was cool to use Spotify and not cool to be an Apple Music or Tidal user. The slow but continued atrophy of client support only builds distrust in this narrative. And that gap is closing when compared to other services.
No Sony cannot ban Steam accounts. Only Valve can do that. And generally only does it for reasons like circumventing geo-blocks, malicious activities like spamming and scamming, excessive chargebacks.

Various types of community and game bans are up to developers, but those apply only to single game.
Hetzner doesnt offer any SLAs which is important for some people
Wonderful post, thank you.
I would probably use Matlab for that sort of stuff tbh. Is K faster than Matlab?
That was one of my thoughts.

Another is that p-p fusion is fairly common. Look up when the Big Room's bright and you'll see a ... stellar example yourself ;-)

(p-p fusion dominates in stars < ~1.3 M, where M is a solar mass. CNO fusion is typical of more massive stars.)
I used to use K professionally inside a hedge fund a few years back. Aside from the terrible user experience (if your code isn’t correct you will often just get ‘error’ or ‘not implemented’ with no further detail), if the performance really was as stellar as claimed, then there wouldn’t need to be a no benchmark clause in the license.
It can be fast, if your data is in the right formats, but not crazy fast. And easy to beat if you can run your code on the GPU.
You can use these to implement Rust-style `auto x = TRY(...);` in C++ which is pretty nice. Unfortunately MSVC doesn't support this extension.
Show HN: Ente Auth – FOSS multi-platform Authenticator
I didn't say long time to write it. I said maintained by a team over time.

Sure there might be some substantial software that was written as a one-off (ie not modified after release), but that's the minority by far.
"Intel Management Engine 2: The Sequel"
Well, Alcohol is an even more easily accessible fuel that your body can readily use for a variety of activities... but its negatives are well understood...
Of course not

You put yourself in a bad spot. We can either kick you out or work (for a price) to help you.

Extortion ? Hardly. Nobody work for free, you know.
Reminds me of the “Social Credit System” in China
If I throw a bowl of scraps to my chickens or dog or cats they go for the highest value things first which is meat and fat. Only after everything has been pecked and licked do any of them consider carrots and lettuce.

Meat provides many vitamins and nutrients in a highly bioavailable form. No one is addicted to meat. It’s a great nutrient delivery vehicle and looking at how many ways we have invented to cook it and increase its digestability it must have been useful. Grains and plants seem to be fillers to a main meal, throw in a bunch of vegetable matter in a pot with stringy meat to make it go further is how many poor people eat and the reason for the beans and rice. Any family that can afford to throw in some chicken legs or entrails or even muscle meat is going to do so into those beans and rice.

In one of the third world countries I lived in they would often tease people who could only afford beans rice and plantains because it was noted they were not as intelligent. Anecdotal sure but a common sense wisdom found in different and less affluent areas.

Furthermore, I can take your argument and use it the same. Eg Many people don’t eat vegetables, they only eat meat, and they are doing fine and many say they are doing better than ever. Let’s not make incorrect statements, vegetables are not key to anything.
Calories are pretty much meaningless. The kind of food, proportions of carbohydrates, and other components is very critical. Nutrition =/= filling gas in a car.
Hello HN,

We built an authenticator app[1] that is open source[2] and offers end-to-end encrypted[3] backups.

Since launch[4], the product has evolved a bit[5][6].

Auth is now available on Android, iOS, Linux, Mac and Windows[7]. We also have a read-only companion app for the web[8].

Backups are optional and free. You can use all our apps (minus the web) without an account.

You can also self-host[9] if you wish.

Please check out Auth, we'd be grateful for any feedback!

[1]: https://ente.io/auth

[2]: https://github.com/ente-io/ente

[3]: https://ente.io/architecture

[4]: https://ente.io/blog/auth/

[5]: https://ente.io/blog/auth-v2/

[6]: https://ente.io/blog/auth-v3/

[7]: https://github.com/ente-io/ente/releases?q=tag%3Aauth-v3

[8]: https://auth.ente.io

[9]: https://help.ente.io/self-hosting/
CISA's KEV Catalog: Known Exploited Vulnerabilities
You could run linux on an M-Series mac, not to sure how stable it is atm, but might be worth a shot
What does Ireland having the same size and population as Virginia have to do with my comment? Virginia is a state and I was specifically referring to Loudon and Prince William Counties, which are very tiny in proportion to the entire state of Virginia. Look up "Loudon County Data Center Alley" to understand the proportions and density of this project.

https://biz.loudoun.gov/datacenteralley/
In the US, the VIN must be visible from the outside of the vehicle, through the windshield on the driver's side. Covering the VIN from view is illegal.
I've written code with single letter variable names lots if times! But later on it most certainly does not make sense to me.
Did you do a full "water fast" during those six days or an intermittent approach and did you supplement electrolytes or take any other supplements?

Genuinely interested, hope this doesn't read as the often common "you should have done this" reaction I commonly see when discussing certain diets or fasting.
So that version of MAcOS had no possibility of some command line shell scripting?
Glad to have found this! I've been looking for something like this because I'm working on a fun, quick side project and don't want to use something boring like bootstrap for it.
I mean, it really depends on who your customers are. You can charge a lot if you can make the typical financial analyst 20% more productive.

Wouldn't work the same way if your core customer base is elementary school teachers.
No mention of the NaCl from the seawater?

If you boil seawater slow enough, yeah hardly any salt would be carried off with the water vapor.

But undersea volcanic eruption? I'd imagine at least some salt would end up where the water vapor does. And at ~3.5% (weight % of ocean surface), that could put a fair amount of NaCl particles in the upper atmosphere.
It's just occurred to me that if Aliens wanted to take over Earth...They could progressively leak scientific secrets, under the disguise of normal scientific progress. This would lead us create a Trojan-ed AGI, that would take over everything, and just build spaceships to ship them all our Palladium...Just imagine a giant spaceship on the way to Proxima Centauri full of stolen catalytic converters....

Can't get into the details, but it seems there is a way to convert Palladium into Dilithium Crystals. When you achieve that all hell breaks loose....
> If you ask 10 backend developers what you should use for your app’s backend, they will probably come up with 10 different stacks.

And now they can come up with 11!
They should probably start with defining what "red meat" actually is. Personally I don't believe that fresh meat of various animals is unhealthy but I try to consume less to none of "red meat products", that is processed meat with nitrite curing salt.
The contract between Sony and Steam in this case. Sony has chosen to restrict the regions Steam can sell in. Steam could honor the contract, or just pay lip service to it and hope Sony don't care enough to invoke their lawyers.
I was able to explore new ideas much much faster using Python than the experienced k people could. But creativity is more important anyway. Ultimately, having good ideas/data/signals trumps fancy or fast data wrangling. Glad I’m doing other things now in any case.
3.1 - Car Thing was likely never going to be profitable but it was continued investment in that social contract. You can bring a Spotify UI everywhere. Even places where maybe it wasn’t needed or already served. But kept the mind share of its customer base. I used mine on my desk for example and was asked about it constantly.
Thoughts:

1) put the “# Short syntax for string type.” comment in your docs on your homepage example. When I first saw the “price” element I thought it was a jsonb field or something

2) why the emojis? So confused. Are those an alternative to a “dash” for entities? Do I need todo those? Do they set the favicon for that rest page? Note: it looks like it messes up indentation alignment. If it’s trying to be cute, I would deprioritize it

3) a “curl” command example on the homepage would make it a bit easier to grok the value of how simple your backend is

4) where does the data get stored? SQLite? Duckdb?
It does exist in the medical world with laws and regulations. For example you can follow the standard IEC 81001-5-1 to tell you what to do. It’s not perfect but it’s a good start and people generally agree that it’s good to implement.

My own solution would be to stop the proliferation of web sites as a disservice, and focus again on keeping private data private, i.e. on the client’s computer. If you don’t have it, you can’t leak it.
Unfortunately with Covid we saw what people are willing to do from both pro and anti PsOV. They were both wrong. Even the CDC and the like put out bad information. Internally they had dissent but dismissed it and went so far as to misspell things so FOIAs would not find things[1]

No one can be trusted, unfortunately, including trusted sources, or platforms or governments. All of the above will abuse their trust when things prove difficult, trust be damned.

[1]https://www.nytimes.com/2024/05/28/health/nih-officials-foia...
Being ahead didn't help much?

I would not say ahead, rather out of step with the times.
The HN ranking algorithm seems to be missing out something here! There's already another, older, story [1] on the same topic currently on the front page, ranked #24. I believe it would make more sense if @dang merged both threads in a single, homogenous one for more value.

_______________

1. https://news.ycombinator.com/item?id=40543408
Electromagnetic Field is happening now
And to be clear, in many, if not most cases, settling for "good enough" is the right call, and spending hours upon hours chasing performance is the wrong call.
That seems really excessive. Another set of informed eyes? Sure. But if you told me that was the process somewhere, I'd tell you I had better things to do.
> They contacted my insurance and the insurance sent them my SSN

If all you're doing is making them get the information from someone else, what exactly are you accomplishing? Adding a bit of friction to a process?

I mean, fine, if that's the aim, but it sounds like this was intended as more of a “they don't need this information at all, and if you don't give it to them, then they won't have it” technique, and (apparently) that doesn't work.
Zato Blog: Web scraping as an API service
Keto flu happens when you transition because of loosing too much water that was retained by carbs and electrolytes gets flushed with the water. Very easy to fix by taking a electrolyte supplement when starting keto (LMNT etc).

> then diabetics would the the healthiest people of all. Instead, they are poison, and this is well documented.

It is documented on T1D, where they make no insulin at all! Keto still helps on T1D, you will always need insulin, just less, and have more stable blood glucose (and all the benefits that entails with it).

For T2D, it's the best solution for it (see virtahealth.com for a great company that helps on this).
There are no many reasons why new analyses should default to using ROOT instead of more user friendly and sane options like uproot [1]. Maybe some people have some legacy workflow or their experiments have many custom patches on top of ROOT (common practice) for other things but for physics analysis you might be self torturing yourself.

Also I really like their 404 page [2]. And no it is not about room 404 :)

[1] https://github.com/scikit-hep/uproot5

[2] https://root.cern/404/
I think the point is in comparison to some animals, we don't extract the full amount of nutrition available in plants (which requires a much larger gut and more energy digesting).
keto diet is a fad, that's big news! Please write a peer reviewed article in the BMJ about it we all want to know.

https://nutrition.bmj.com/content/early/2020/11/02/bmjnph-20...

"Insights from a general practice service evaluation supporting a lower carbohydrate diet in patients with type 2 diabetes mellitus and prediabetes: a secondary analysis of routine clinic data including HbA1c, weight and prescribing over 6 years"

Most read paper of the BMJ ever.

Follow-up:

https://nutrition.bmj.com/content/early/2023/01/02/bmjnph-20...

"What predicts drug-free type 2 diabetes remission? Insights from an 8-year general practice service evaluation of a lower carbohydrate diet with weight loss"
Not sure if you are suggesting a shift for better or worse and over what time frame.

Despite my personal unemployment it seems things are better than they were in early 2022
Grain: The High-Level Language Optimized for WebAssembly
So many points. Does your thinking start with “it is obvious that…” or “the right side of history” ? We as humans are just very susceptible to a combination of fallacy and social reinforcement, no matter our political stance.
When writing code in this manner, lines of code is kind of a meaningless metric. You could put the entire Linux kernel in one very long line of C.
"if you can afford to bike in Loudon"

I don't follow your reasoning. It costs nothing to ride a bicycle in most of America. We have bike paths everywhere that are free for anyone to enjoy. You also don't have to live in a locality to enjoy the bike paths there.

For the record, on this specific outing I was doing volunteer trail-surveying. I live in Prince William County. I think the Data Centers are awesome and I love them, the tax revenues they bring in, and the jobs that come with them. It was clear from my comment that I am conflicted about the incredible energy-consumption, not the data centers themselves.
> now they're just hosing your consumer router

There is a dramatic difference in effort between ( owning a device ) and ( owning a router, configuring network access to the device, then owning the device ).

Also psychologically: If I was a rock hard piece of shit and I knew I was at the doorstep of a personal device, I would treat it much more aggressively than a router. I suppose maybe that's just me and not the kids and enemy states.
Thanks for doing this, wishing you the best
On the contrary, economists have known for some time [1] that this (investing in improvements to their product) is exactly what monopolies DON'T do well.

And the DoJ is suing Ticketmaster for being an abusive monopoly as we speak, so.....

[1] Actually, we've known this as far back as Adam Smith! He talked a fair bit of shit about monopolies in The Wealth of Nations. His "invisible hand," after all, was competition, which monopolies by definition don't have.

Remember this every time someone talks shit about capitalism and points to corrupt and abusive American monopolies as evidence of why it's a failed system. America's government only really started leaning into its modern love for monopolies from the Reagan administration onward - in defiance of centuries of evidence that it was a bad idea.
Aliens already took over earth, we are the aliens.
But but look at all the Turing Award and Putnam Prize winners he was worked with.
Ask HN: How often do you "Show HN" in your mind before starting a project?
I've begun to wonder whether it's unhealthy.
Just packaged it up on my private Guix channel. Here's the package def (along with the one for ngn/k as well) if anyone's interested: https://gist.github.com/xelxebar/c37ab9285b297fed3e9e0f9ce78...
It is not that bad now with pyroot (ROOT python interface) and uproot being an option that is easy to learn for new graduate students. The problem is about legacy code which they usually have to maintain as part of experiment service
Would you recommend K?

Is something else better (if so what)?
Yep, though RTO was the straw that broke the camel’s back. I had had 3 direct managers in a year and a half, had projects sunsetted out from under me, and several reorgs. Add in a forced return to office and I was out of there.
These days you can mostly avoid it. The Python HEP ecosystem is now pretty advanced so you can even read ROOT files without needing root itself. See:

https://scikit-hep.org/
They didn't actually determine it. The cheated by giving it a single letter variable name, and ran with it. It's the mathematical equivalent of buying using a rubber check that is never cashed, so everything is OK.
Create a fake google page, inject it into their history, the users goes back, sees something google like, now you’re 100% evil, congrats! :)
Yeah, but we have no Tentacles, so we are considered a kind of subspecies, and ostracized in Galactic social circles...
They’ve definitely gotten the repeatedly-named Snowflake employee in a lot of hot water.
Heres how I do it. I just use express.js, sequelize (sqlite) for ORM, nunjucks for templating. Then on the frontend I use VueJs 2 which I use like jQuery - no compile step no components. Throw in some Bootstrap 4.5 because I dont need the new features of 5. Deploy on a $5 lightsail server. Done!
Thank you for your feedback. I will look into it.
That's not the idea. In a sense, the Pandoc of K is K itself. I mean its designed for interactive, fast and terse scripting on financial data for quants. And it's incredibly good for that. So almost all substantial K is proprietary.
The obvious problem is that we do not know what's true and what's false until way later.

We can tell "organic" from "forced", perhaps, but then the results will not be pretty for any political camp.
wish I could say the same
What amazing is that in China there are many companies with popular EVs just driving around merrily, many of which are barely heard of outside the country. BYD obviously, but also Aion, Leap, Nio, XPeng, it goes on, plus the "old" car companies like Chery, Geely, SAIC, etc. Even Volvo has an electric minivan now in China.

You can have a completely fine EV for maybe 10 thousand US dollars, and a pretty great one for 20. And they're
often car-shaped cars or people carriers rather than a blobby crossover or fake-macho SUV (though the rather compensatory Tank, no really, that's the name, hybrids kind of balance it out)
If you have refresh tokens in your first-party authentication flow you are already a good way down complexity lane - best to avoid IMO.
These abstractions are great but are contributing to brutal de-skilling.
"As for sociodemographics, we found that supersharers were significantly more likely to be women, older adults, and right-leaning"
How to compile these codes under clang15?
To be honest I would not expect using SMR drives in some important production systems.

I would even prefer to use CMR ones ... but the 2.5 drives with 4-5 TB capacity are only available in SMR - maybe in the future when 2.5 drives will ofeer 8-10 TB of space - there would be a 4-5 TB CMD 2.5 drive.
My litmus test is what advertisers, marketers and salesmen can do, as the limit of that is where it turns into illegal scams. Yes, I claim this is a continuum, the legal line dividing shrewd business from fraud is arbitrary, and IMO placed way too far towards the "fraud" end, i.e. allowing too much.
Highly educated people get hoodwinked by "fake news" and pseudoscience all the time though. I don't have a solution and education is certainly a step forward but the issue is much more complex.
Language skills, not language skills!
I’ve always told myself- no matter how smart my idea is , if no one else understands it it could be as if it didn’t exist.
There's usually a relevant Reddit subreddit. Include enough search terms at the bottom of your post and your solution will be discoverable. For redundancy, put it in something like a github gist as well. Also email or contact some of the people who previously asked the question.