skysight-inc/HackerNews huggingface dataset:
No. Most kids strive to follow whoever "mentors" and teaches them.

What is sad is that this job is left to influencers. Not the kid's fault if our education system, parenting and attention economy are completely f'd up.
Five isn't but fifteen begins to feel like one, because the only practical way to respond is to read the sources and give your own high level conclusions, the same way the person who gave them is doing, but then you'll be accused of not dealing with specifics, and then if you deal with some specifics but not all of them, you'll be accused of not dealing with all of the facts, and so on.
>>> Modern JavaScript features like async/await and a more flexible type system

So Skew only had callbacks?
Monocultures are fragile.
Eric Lippert "Wizards and Warriors" in 5 Parts (2015)
I am so happy that the author of this piece clearly states, right up front, that ElMu did not actually found Tesla! The marketing aimed to perpetuate this misunderstanding has always irked me...and led the entire world to believe stupid things about this guy.
> Only in December of 2022 did scientists at the National Ignition Facility at the Lawrence Livermore National Laboratory announce that they had achieved the first recorded fusion reaction with a net energy gain

We've been achieving fusion reactions with net energy gain since the 1950s, when hydrogen bombs were developed. And, on top of that, the achievement they're talking about was more energy out than light energy put in from lasers. The NIF lasers are not anywhere close to 100% efficient at converting energy to light, and so it was not actually net energy positive.

NIF is not going to lead to fusion power. That's not the point. Fusion bombs are primarily an engineering problem. There's lots of plasma physics going on that is very difficult to simulate with a computer, and you need real world data to inform the simulations to make sure they're working properly. That's what NIF is for. Instead of having to blow up a nuclear bomb, and violating test ban treaties, NIF can produce that data. And with the PR shine of tying it to fusion energy.
Mini-colons advance colorectal cancer research
Why are these trials organ specific? Lung cancer, pancreatic cancer, etc. Does it really matter?
You only need to try the _prime_ bases up to 2 log^2(n). So the total number of bases here would be 79060.
When you consider that human behaviour is just trained by evolution and experience, with a bunch of stochastic effects in the mix, it’s hard to justify this magical notion of agency.

At best, agency could be seen as a “degree of indirectness” of some external influence.
I just use trello. I have columns for songs, movies, roadtrip ideas, coding ideas, you name it.

Everything looks the same everywhere, desktop, phone, tablet.
If they cure cancer with an mRNA vaccine will the morons opposed to the polio vaccine take it?
I find perfectionism gets in the way in such conversations: the goal is aiming for the freest market possible, but no - you can't legally sell services to assassinate people; unless you're the state who has a monopoly on violence.

Because on the other side we have people blaming the free market and capitalism in general for the problems, when capitalism is the solution - it's crony capitalism or what I prefer to call it - corruption and things like regulatory capture that's the problem.

The problem is heavily industrial complexes' funding and lobbying of politicians, placing politicians who will favour policy for them - is the problem; and it appears that foreign bad actors have also helped certain politicians get elected elsewhere.

I like the Democracy Dollars and Journalism Dollars solutions proposed by Andrew Yang during his presidential run to help act as a counterweight to the power of industrial complexes.
Just my 2 €cents:

I have bad experiences with HD and optical, while having positive experiences with Flash.
But I've read blog posts claiming exactly the opposite.

Nowadays I have copies on at least 2 Flash and 1 HD for the important but not so voluminous stuff.
https://archive.ph/L93Y7
Why do you belittle African countries like that?

Do Africans deserve less enforcement of things their government has not approved than people in other parts of the world?

Would you be OK if some country started making high-current electrical devices that were not approved and then just forcefully sold them in your country, even though regulations prohibited it?
It must be fun looking at their backend regarding events on your account: "This song just got promoted to a movie!"
They will oppose it until they get cancer and then it will be too late and they will cry about government conspiracy keeping them from accessing life saving vaccines.
For the vast majority of Americans social status is directly tied to income or wealth. As long as this is true the profit motive will be the highest motive for most people.
Unrestrained capitalism.
Valuing intangible things ≠ whinging when those intangibles are no longer adaptive to circumstances.
You May Soon Be Drinking Synthetic Coffee
This point of view isn't common, get used to it!
I know you're trying to help, but this further highlights the problem with frontend dev.
People are free to spend their own money however they wish.

Similarly societies can tax whomever and however they see fit.

…should be happy when they see billionaires spend excessively, as it means that wealth is getting spread around.

This reasoning applies when government taxes billionaires and spends it.
Creator here, there was a big HN post that caused that big boom during Christmas
Are there really many people that think that cows and pigs are not conscious? I would be very surprised. People eat meat despite the fact that it involves murdering animals. I don't think anyone really likes it but I don't think many people are so deluded that they think farm animals are not conscious.

Maybe religious people I guess, if they have weird ideas about souls.
Yes, I think so. Trust the online service s/b pro.
Cancer is cell-specific. Organs are made of different types of cells specific to that organ. Lung cancer is not the same as pancreatic cancer is not the same as breast cancer, etc. If cancer was not cell-specific, it would be much easier to synthesize treatments for.
Could I ask a dumb question, what does it look like when a model isn't aligned with its intended output? Does the text look off-center?
> If they even care about that.

Yea, something I've noticed lately is that companies are beginning to be OK with letting go of customers they can't just silently and passively milk forever. It used to be, you could call up your cable company and threaten to cancel, and they'd pass you over to a "customer retention" specialist who will give you a deal that lowers your cost to what it was a few years ago. Last time I tried that trick, they put me on a brief hold and then came back to the phone with "OK, sir, your service is canceled as of today. Is there anything else I can do for you?" Whoops!
As a good example of how clueless we are, look up 'blindsight' where people are blind (i.e they cannot see anything or observe what they see), and yet they can actually see by all quantifiable metrics (ie, when asked to point to the blue ball, they correctly do so; they avoid obstacles, etc). The eyes and visual system works but they have no conscious experience of it. Why? No one knows
I disagree, it seems to deride a certain flavor of ethics. Almost an "appeal to nature" regarding whether humans should treat animals a bit nicer knowing they experience things.
As I become older (and grumpier) I have realized that not engaging is the best thing to do, wherever possible. Dirty restaurant / rude staff? Don't go there. Don't like dark patterns on a website? Contact forms don't work? Don't use those sites. And so on. Two reasons - first, most of the time, these businesses know their shit is broken or they're doing low quality work etc. They just don't care. Second, it is good for our own stress levels to avoid dealing with shitty stuff.

Obviously this can't be applied to essential services like healthcare etc.
Or finding that `savePaypalTransactionToDatabase` doesn't return the row ID, but instead returns true/false to indicate success, and not being able to easily refactor it because god knows where that function is being used, and what sorts of knock-on effects it can have, even with a decent IDE, and deciding "fuck it, I'll just write a wrapper around it that then queries for the

You know what, nevermind, it's Saturday, why am I thinking about work.
If you read the article itself, it's probably also just generally not a great idea to drive vultures into extinction.
I don’t believe in free will either. You might like Determined by Robert Sapolsky. That said there’s a difference between a CPU executing a static program, and a human with self modifiable programming and actual existential parameters. Is a computer with a survival instinct and the ability to meaningfully adapt to affect its own survival agentic? I’d say yes. Conscious? I couldn’t say for sure but I also couldn’t rule it out
The mutations and vaccine are usually specific to the type of cancer, so yes one treatment won’t help a different kind of cancer. Unfortunately, of course, but that’s the way it is.
How do you help patients who show up in the ER 100 times a year?
I've tried it, twice, with Zenni Optical - both times it's been a bust. They've allowed me to put in a prescription and place an order for things they don't actually support (e.g., prism).

That said, I know a lot of people swear by them. I'd say that if you have a dead simple prescription (that is, you don't need progressive lenses or anything "complicated") it's worth trying. If there's any doubt, they have an OK refund policy, so if you're quick about returning glasses that aren't quite right, you're only out the wait and a little hassle.
> What happens when it's too slow?

Sleep?
What are the top mental models to increase common sense?
Common sense can have different definitions. But how to increase it?

These are 2 effective ones

- 2nd order effects
- 1st principles thinking

What else?
Not really, for two reasons.

First, merge only ever allows you to arrive at a single commit, so it's strictly less powerful than rebase. With rebase, you could start with a sequence of three commits, "A", "B", and "squash! A", and turn that into two commits, "A'" and "B'". Merge doesn't let you do that.

Second, sometimes a merge commit really is semantically useful and you want it to be shown as a merge with two parents. There is no canonical way to distinguish this kind of merge from the kind of merge you seem to be thinking of.

Personally, I think the way to resolve this would be to have optional "squash/cherry-pick parent" metadata on a commit, so that commits that result from a cherry-pick or a rebase can point back to the original commit(s) in a more structured way (remember that a rebase is really just a sequence of cherry-picks). This metadata could also be used to preserve `git commit --amend` version history. Augment it with a "reverse diff" bit and it can be used to track reverts as well.
Command Line Data Visualizations [video]
Cancer isn't one disease, any cell could potentially become cancerous and they can potentially become cancerous in different ways. A universal cancer vaccine will probably never happen, but hopefully we'll be able to have enough coverage of the more common ones such that cancer is effectively eliminated.
Tip for "collecting structured data": you can prepopulate the email body using a mailto: link with a "prompt" to the sender to fill out the data you need.
Would you say buying pre-packaged meat is an instinct? I haven't had a hard time overriding that instinct in my lifetime.
Only had the pleasure of lunching with him once as a young researcher at an a-life workshop. The man really had that gentle giant demeanor and impressed me as a true renaissance man with great breath of knowledge.

( And hi Anil, in case you stumble in here :)
Yeah agree, owning your car is, like, the one thing I would like companies to free us from the burden of.
Worst job interview I ever had was when I had to sit with three other candidates side by side as the employer interviewed us, and then played us off one another.
It's hard for me to imagine a new cycle that has the buoyant properties of the tech software cycle. The ability to buy a PC, teach yourself coding, and build something is a historically unprecedented level of of opportunity for innovation & disruption.

There's much focus on the rent seeking world, on the vast assembled powers. And a more just and better world would have better answers for meeting with these imbalances. But I think it also masks the counter-narrative that it's about us (humanity) and our empowerment & how we sustain choice & agency & create systems where we aren't as likely to be pushed under the yolk.

And it feels like software ought have a lot of opportunity here. That our user agency ought be building, that it ought blend into a creative agency. A more malleable system of systems where we still retain property rights & options, not all given away in the shrinkwrap terms of service & felony offense of business model to bypass their technological protection measures. We ought be making post-industrial and proto-humam open source software that tries to expose its guts & is a live interactive world of software, not dead programs.

Maybe innovation comes from outside IT. But gee it feels like so much of the world is so capital intensive, that most people won't get their own personal stake. Amplifying the person's/personal stakes: that feels like how we keep homo erectus making tools and making their world. The personal computer still feels key to this.
They’re not organ specific, they’re disease specific. Despite all being called cancer, they’re not really the same disease and each variant might express different targets or react differently to the same treatment.
No, my contact form, but just rephrasing the author: why do you put a contact form and don't perform QA and best practices on it?

Also, the contact form is just another channel (that should work) but not the center of contacts. For example WhatsApp business replaces a lot of these forms in many regions.
Lessons on Creativity and Human Nature from Rory Sutherland and Rick Rubin
Activist Groups Trained Students for Months Before Campus Protests
Groq is not general purpose enough, you'd be stuck with a specific model on your chip.
There was a really popular trend among cryptocurrencies at some point of creating a new proof of work function as a way to differentiate your coin from the sea of Bitcoin clones. Coin creators would then make unsupported claims about why their new pow was better than Bitcoin (claims such as GPU, resistance, asic resistance, or some kind of social good were common). In the case of the prime number coins (primecoin, riecoin, nexus, probably some others), it was marketing that doing the pow would, in some hand wavy way help "science". Bullshit, mostly, but...

All pow functions are just about proving that you wasted work, so there's nothing really inherently wrong with using something prime number based. The problem is that you don't really want to have mathematically and implementation intricate proof-of-work functions, because then some jerk like me comes along and is able to create a much more optimized miner, keep it private, and make money at the cost of having the other miners feel like the game is unfair. New coins in particular depend on those miners acting as marketers to shill the coin, so if they are grumpy, you lose part of your marketing team.
That's a consequence of the choice not the reasoning for it.
Cultural and religious traditions bind us to the past and the future.
Yeah, your rates are set by what the other guys charge. They won't pay $30000 when someone else is happy to do it for $100/hour and get it done by the weekend.
It's interesting Akeyless is mentioned most often as a vault competitor. Why is that?
The request-per-module thing only happens with the Vite dev server: production builds are bundled with rollup similar to webpack.
Yes. "Cancer" is over 100 different diseases, all with different pathologies: https://en.wikipedia.org/wiki/Cancer#Research
good explanation! ++1

same with donkeys vs horses
These reviews convinced me
yes I only had time to read the last paragraph.
Ask HN: Best pay-once shareware software for Windows?
Taxing billionaires is a good first step. Let’s reassess the situation after this happens.
2000. ;)

"Hohndel [sic] reckons the current trend toward the open source model has only one conclusion: that Linux will become as prevalent as Windows on the desktop within the next two to three years."
-- SuSE's Dirk Hohndel talking with ZDNet, 2000
Perhaps because there is not one disease named cancer but many diseases sharing the same umbrella name.

After all, cells in each organ have often specific shape, receptors, behavior, means to communicate with other cells, etc...
Robert L. Sawyer wrote a more entertaining version of this: https://www.goodreads.com/en/book/show/337133
Or by adding back brown rice to cookers. Same deal as whole grain breads, a healthier option. Won't work for sushi, but sushi comes with fish slices on top too, so...
> it's probably also just generally not a great idea to drive vultures into extinction.

On that we definitely agree! My comment is about people making it all about them.
Diclofenac has been banned in India for veterinary use since 2006. Another NSAID that is not deadly to vultures is recommended for such use. Not sure why Guardian ran this story now as this is old news. The real crisis with plunging vulture population goes far beyond Zoroastrian burial rites. See https://en.wikipedia.org/wiki/Indian_vulture_crisis
> Where was brown rice the traditional way of eating rice (for non-elites)? During what centuries roughly?

My understanding is that it was the usual way of doing so until mechanization made it affordable.

> What is your evidence?

I remembered reading it on acoup, and that's indeed the case:

> Consequently, while a diet of mostly brown rice can be healthy, a diet overwhelmingly of white rice leads to Thiamine deficiency, known colloquially as beriberi. My impression from the literature is that this wasn’t as much an issue prior to the introduction of mechanical milling processes for rice. Mechanical milling made producing white rice in quantity cheap and so it came to dominate the diet to the exclusion of brown rice, producing negative health effects for the poor who could not afford to supplement their rice-and-millet diet with other foods, or for soldiers whose ration was in rice. But prior to that mechanical milling, brown rice was all that was available for the poor, which in turn meant less Thiamine deficiency among the lower classes of society.

https://acoup.blog/2020/09/04/collections-bread-how-did-they...

Edit: now that I looked up on Wikipedia, Thiamine is actually vitamin B1, not Vitamin A, so THIS IS NOT THE SAME DEFICIENCY and I stand corrected.

Too bad I can't update my comment above anymore, because it's conveying false information based on an incorrect understanding of mine…
I think they want to spread out the bets and expect a bunch of these to become acquihires fairly quickly.
Comment from a few days ago:

MRNA and personalized cancer vaccines are showing tremendous potential in a lot of cancers: https://jakeseliger.com/2024/04/12/moderna-mrna-4157-v90-new... GBM is particularly gnarly; one of the few other treatments in trials I'm aware of is DCVax: https://www.uclahealth.org/news/article/fda-approval-brain-c...

One big problem is the FDA's slowness regarding treatments for otherwise fatal diseases like GBM (or recurrent / metastatic squamous cell carcinoma of the head or neck, which is killing me).
Always shocking to see how the sausage is made. Some of these would have to be a. foreign agents and/or b. co-financed by groups connected to extreme middle east organizations.
I've been using Zenni for over a decade, and I've had nothing but great experiences, and I recommend them very highly (especially to a neighbor who was complaining about paying FOUR HUNDRED DOLLARY DOOS for his son's glasses somehow.)

They certainly try to upsell you on many features during the checkout/order process, but it's not pushy and I've always gotten exactly what I ordered. But you make a good point - my lenses are a fairly straight-forward prescription for near-sightedness.
I don’t want to litigate “free will”, but a computer can be compared to an organism just fine if you stick to concrete terms like “complexity of behaviour” or “how directly its behaviour is programmed” (very directly) as opposed to indirect learning. People aren’t satisfied by such talk because people cling to their beliefs of self-importance: having some magic intangible property makes people feel better about their sense of importance and their place in the world.

I think in general it’s best to avoid “arguments by incredulity” (eg.: how could it be this or that, it’s just a rock, that’s absurd), and to avoid value judgments, etc. We really need to humble ourselves as a species.

It’s perfectly fine if humans are just (and I really do mean “just”) chemistry with some higher structure— it doesn’t change who we are, or our role in society. Even for religious people who believe in a god or in many gods— it’s fine if we’re not magical. We learned that we weren’t the center of the solar system, or the center of the universe, and everything was still just fine.
>brilliant to people going through difficult times in life or edgy teenagers who are angry at the world, but to be blunt it falls flat for people who are well-adjusted and thriving.

Quote: It is no measure of health to be well-adjusted to a profoundly sick society ~ Jiddu Krishnamurti
To be fair to the GMO's, it's not that they try to create sterile plants, it's that much of their benefit comes from hybrid vigor. https://en.wikipedia.org/wiki/Heterosis
> how do you make sure you don't make any mistakes while doing so

My prescription is fairly simple, so there's very little that can go wrong. I just double-check my prescription against what I'm ordering, and voila, $25 glasses that I don't have to worry _too_ much about my child stepping on.
> I was scared of GM crops when they first started getting news attention, but I've flipped now.

I think putting this into binary options, of pro-GM, anti-GM, is not ideal.

It's like saying "I am pro-chemistry," or "I am anti-chemistry."

Just as with chemistry, various GM products can have largely positive or largely negative outcomes.

The question which needs to be asked on each and every GMO product introduction is along the lines of: is this new product like creating fertilizer from natural gas, or like adding lead to gasoline?
Interestingly, this is a matter of debate right now: see "Forget lung, breast or prostate cancer: why tumour naming needs to change: The conventional way of classifying metastatic cancers according to their organ of origin is denying people access to drugs that could help them" https://www.nature.com/articles/d41586-024-00216-3

A number of companies have sprung up that'll try to a tumor sample to a variety of treatments in order to figure out whether treatments from other tumor sites may work better.

My own tumors originated in my tongue; now I don't have a tongue any more (https://jakeseliger.com/2023/09/09/life-swallowing-tasting-a...) and the tumors reside in my neck and lungs. A lot of oncologists who specialize in head and neck cancers also work in lung, since there seems to be a lot of overlap between the two.

I don't know this for sure, but I think DNA profiling is changing how oncologists, and people more generally, view cancers, or at least many cancers. Decades ago, it wasn't feasible to take molecular snapshots of cancers. Now it's still not quite standard, though it should be, via companies like CARIS: https://www.carislifesciences.com/