skysight-inc/HackerNews huggingface dataset:
I've been looking at yeast to see if it is possible
to create a NOR gate. Then the game is to use the CPU that someone
created in Conway's game of life to create a yeast-based computer.

The CRISPR stuff:

"We demonstrate the world’s first successful editing of the human
genome using a gene editing system where every component is fully
designed by AI. Our most performant AI-generated editor, OpenCRISPR-1,
achieves similar activity and higher specificity than SpCas9, an
exemplar gene editor, while being highly dissimilar in
sequence. Moreover, our platform is capable of generating many more
gene editing systems at-will; OpenCRISPR-1 is just the tip of the
iceberg. We publicly release OpenCRISPR-1 to facilitate broad, ethical
usage across research and commercial applications. In making this
molecule available to the broader community, we hope to lower the
costs and barrier to entry for therapeutic, agricultural, and
scientific applications of CRISPR-based technologies."
https://www.profluent.bio/blog/editing-the-human-genome-with...

Conway's Game of Life CPU:
https://www.youtube.com/watch?v=Kk2MH9O4pXY&ab_channel=AlanZ...

Yeast-based NOR gate:
https://www.nature.com/articles/ncomms15459

I've finished one textbook on yeast so far. I've looked at doing CRISPR at home:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053061/

There is an ongoing effort on "yeast evolution" to create new kinds of yeast behavior
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225242/
and, in particular, yeast seem to self-specialize when, through "directed evolution"
they start to cooperate
https://www.sciencedirect.com/science/article/pii/S200103702...

There already is known machinery to do switching in cells:
https://www.amazon.com/Genetic-Switch-Third-Lambda-Revisited...

This form of epigenetics allows all kinds of interesting responses to
external stimuli. In particular, it would allow "chemical questions"
to be asked.

It would be possible to create a cellular "display":

"Scientists from Trinity College Dublin, in collaboration with the
Royal College of Surgeons in Ireland (RCSI), have developed special
fluorescent, color-changing dyes that, for the first time, can be used
to simultaneously visualize multiple distinct biological environments
using only one singular dye.

When these dyes are encapsulated in delivery vessels, like those used
in technologies like the COVID-19 vaccines, they “switch on” and give
out light via a process called “aggregation-induced emission” (AIE).
Soon after delivery into the cells their light “switches off” before
“switching on” again once the cells shuttle the dyes into cellular
lipid droplets."

So when your Petri dish "yogurt" "sees you" open the fridge it can
change the surface to say "Hello". Coming to a fridge near you...

I suspect it gives more weight to "a gut feeling" when your stomach
can argue for a viewpoint in actual words. We'll leave off the question
of how to avoid angry mutterings from your toilet :-)
Only if the return types are identical.
>Forget taking my truck to the lake with the kayaks and forget hauling materials to build my house.

This is totally not how you move to Paris.
> The LWN article indicates 24 maintainers have removed themselves, which appears to be ~0.7% of the maintainer list. Were these people particularly impactful? Is there an actual crisis here?

Maybe a handful of them. One of them was an extremely prolific (#3 contributor to Nixpkgs) and active contributor that no doubt everyone will miss. There's at least one other name I recognize on the list. But most of them are pretty small-time maintainers so far.

> I also don't really get it; are they going to use a different (worse) OS because of this?

They're saying they're going to fork. There's one fork emerging already, but idk if it'll be the one. I hope a productive and usable fork does arise (and that eventually it can rejoin Nix) but I'm pessimistic that any will survive.
Honestly, I don't care if other people are creating similar things to what I am. Actually, I prefer if there are more people working on the same things because it means there are other people that I can talk to about those things and collaborate with. Even if I don't want to work with others on a project I'm not discouraged by other implementations existing, there's always something that I would want to do differently from what's out there. That's the whole point of building my own things after all; if I were happy with using whatever bog standard app I could find on the web then why would I need to build it? It isn't just about making it my own either, it's also about the fun of diving into the guts of a system and seeing how things work, having a machine capable of producing that code gives me the fantastic ability to choose only the parts I'm interested in to do a deep dive on while skipping the boring stuff I've done 1000x times before and I don't have to type the code if I don't want to, I can just talk to the computer about the implementation details and explore various options with it. That in itself is worth the time spent on it but the awesome side effect is you get a new toy to play with too.
Increasing Number of Lung Transplant Patients Living Longer
I am not referring at those bots.

I am guessing here, no data or proof,
but there are a lot of very young accounts that defend Putin, defend soviet war crimes , try to cause chaos, do personal attacks in comments. This accounts have sometimes real people behind but for sure bots/scripts are used to create them and then farm karma/points to be allowed to post. Someone like me with a single account for years must always be sure to fllow the rules, this bots/trolls are always aggressive, spread false shit and do not care if banned, and seems reddit is fine with same troll making many accounts and use them for bad stuff.

Because some subreddits require you have some karma before commenting, more karma to be allowed to post I assume this trolls use scripts to post random stuff to get this karma points. There are bots that find popular past submission and post the same thing again to get the karma points.

So EU or USA needs to tell reddit that they are responsible for the shit posted by bots and we will see tehm inventing ways to stop 99% of them/
Here in Bulgaria we only technically have bankruptcy but it's extremely different from the USA.

Long story short, a judge plus two gorillas can and will confiscate every single thing you own and then put you in jail.

Bankruptcy is not a "haha, you'll never get me!" card like it's in the USA. It's actually diametrically the opposite.
Insects are important for human survival.

The article is probably related with the studies that show an allegedly decline of insects in the current sixth extinction context.
Like most large social media sites, pre-Musk Twitter had some combination of algorithms and bureaucracy that act as a chaos monkey to shadowban and suspend accounts apparently at random, often with an inability to comprehend satire or under incoherent or undisclosed pretexts. The site's users and staff were predominantly left-leaning, so right-leaning accounts were disproportionately the victims of these false positives because of human bias in which posts are flagged and how they're subsequently moderated.

Musk bought the site under a claim of doing something about the bias after Twitter suspended the account of a right-leaning satire site. Many of the existing users were displeased by this, because they liked having a site whose moderation system was biased in their favor, so some of them left. Meanwhile new right-leaning accounts were created as you might expect. This affected the ideological balance of the site, so even though it's still somewhat left-leaning it's less than before. And now when the drunk chaos monkey suspends an account on the left, people are finding new satisfaction in their ability to blame Musk in particular.
Sadly there's no "interaction" in blog posts
Scripts using #!/bin/sh instead of #!/usr/bin/env (ba)sh won't use your shiny new shell. Including scripts deep inside the build system of misc. software that you won't modify.

The only way is to set their strange /etc/private symlink (cf sh(1)) to change what /bin/sh execs, and to do it again after each update which resets it.
This feels so wrong in one way, and simultaneously so right in another.
I felt it in the past. My experience was related to the environment of the startup I was at. I started it with 2 others but we were all remote and our ideas didn't bounce off well with a sense of energy and electricity. But the people I am working with now are quite different, they love what they do and we get energy and clarity from our interactions. Grinding without seeing results is difficult, so try to get back on the "effective" grind. If the product is built and you are only maintaining code you won't grow as much as you desire. Start a hackathon project! Get back the excitement by testing/working on the mission with a new angle (perhaps incorporating AI? It's pretty interesting to learn-- not sure if it fits nicely into your startup)

Bottomline without too much advice. We feel that we are growing when we are learning and acting deliberately. When we are challenged and stretched to do new things. An idea is to find a feature/idea that needs to be validated to ship an early version of it in front of your customers to test. It could start a new adventure.
I'm not hand-waving the issue; as I said, it's clearly a very difficult problem. But it is not an ethical dilemma; it is a resource-allocation problem. In the United States, we are historically good at solving those, when properly motivated.

Why can't more machines be made? Why are there a limited number of people who can maintain them and perform care on a long-term basis? These are questions that lie downstream of many long-standing institutional problems with the practice of medicine in the US, and framing them as ethical "maybe-some-people-should-just-die" questions is missing the broader story.
Only one human per machine. If you need to share the machine, make multiple containers and give everyone a separate container.
pray tell
> I trust that my bank is well-enough managed to provide me with physical currency up to the amount of my account balance

It (probably) is, but if all of your bank's account holders asked for that at the same time it would be what's known as a "run on the bank" and you'd very quickly find out that they don't have anywhere near enough physical currency to cover even a fraction of their account holders.
I've been playing the piano and composing music for over a decade. Last year, I started getting paid as a ghost composer, and since then, I've been composing more songs per week on average than ever before in my life. I don't regret anything; I love everything I've composed for the person who hired me, and getting paid for it is an incredible bonus. It's almost like a dream come true that I never sought or aimed for. I also didn't feel any less of an artist for accepting payment for my work. I simply believe that we need to take some of the romanticism out of the notion that to be a true artist, you have to starve.
Here’s the rub: that time will have to be spent no matter what. Async just “frees up the thread”, but the system as a whole will still have to do the same processing. Async doesn’t make a gigabyte sized I/O take less time or somehow “go away”.

In fairly extensive tests I found that it is actually pretty rare for threads to be the limiting resource, so async provided no benefit at all.

You pretty much need this specific scenario:

- A large auto-scale pool

- Tuned well to keep load at 80-90%.

- High concurrent connections per instance.

- Slow dependencies that return small volumes of data.

- A much larger back end than the front end. Think 100 VMs at the front and 10K at the back.

Violate any of the above and the benefits seem to evaporate. I’m sure that this scenario is common at FAANG sized orgs, but is extremely rare elsewhere.
however major foss linus distos codes of conduct require them to uphold an equality so perhaps divesting from all ties to israel
> Radio firmware and state machines have always had weird bugs, and even when it conforms to standards (some of which are extremely interpretable), does very weird things in the real world. Pre-smartphone, being able to update phone and radio firmware was extremely rare, so it was common for the networks instead to implement workarounds on a manufacturer or handset basis. Having a hardware ID that identified this was extremely useful

Now that it’s common for devices to be updated regularly, they will typically send an extended form of the IMEI to the network called the IMEISV, which is the same as the IMEI except the final check digit is replaced with a two-digit code indicating the current software version (SV = Software Version).
Signed ssh certs make your life easy here
I have no idea why you’re being downvoted; this is a legitimate concern. If these systems have the capability to apply full braking force at 90 mph, there will be instances when they get confused by a shadow and cause the very type of collision they’re intended to prevent.
My experience is that there is a great, big in-between where folks are just chugging along and aren't thinking about project/codebase level architectural decisions. Without that active thought and foresight, you end up shooting yourselves in the foot, a bit. With DI frameworks, the _default_ ends up typically being the right thing to do so it unburdens people from a particular slice of cognitive load.
Viral TikTok video says nice people don't get promoted. Experts disagree.
I have no idea what you’re saying. It sounds important and interesting but I’d like some more details.
Thank you for creating this excellent article on AI knowledge management! The real-world examples you provided, such as how AI can help doctors access relevant treatment information to improve patient outcomes, really drove home the transformative potential of this technology across industries. I'd be interested to discuss further the best practices around ensuring data quality and security when implementing AI knowledge management systems. I appreciate you including Omnifact Spaces as a potential solution to explore. Definitely an area I want to dig into more. Helpful read overall!
They must be talking about singing in the shower.
squid is a http(s) proxy and pf is a firewall. They do not do the same thing.
How would you realistically enforce the end-user with software distributed under FOSS licensing?
Agreed. I’ve tried to get used to it on Debian 12 for personal VMs. I just can’t. I don’t care. grep and awk are always going to be available, and I know how to use them.
Anyone aware if there is are any provisions under Finnish law for the detention of the defendant to be extended past half the sentence duration? For instance in a case of bad behavior while inside has been cited as justification in other regions.
You can't buy more time...
I am continually baffled at people's use of X-Twitter/Mastodon for this kind of writing. Thankfully I've found mastoreader, which is an equivalent of threadreaderapp.

https://mastoreader.io/?url=https%3A%2F%2Fmastodon.social%2F...
Street design can and does affect how fast people drive. It's weird that you are arguing that it doesn't.
This is interesting. I use Verizon Wireless from the US, and when traveling abroad on their travel pass (roaming), some large multilingual websites serve me the local language instead of English, on sites that serve me English when I'm at home. My browser (Accept-Language header) is configured for only English. I always decline location API browser popups.

The only thing I can think of, assuming they tunnel as you describe, is maybe I first loaded the site from local WiFi instead of mobile data, at which point I was redirected (to a localized subdomain that doesn't redirect back) or got a cookie or something, which lingered as I continued without WiFi.
That can succeed in a number of cases, where it actually isn't a tty with a user on the other end of it. There are a number of internal tools at work that only output logging if there is a tty and thus are run in their cronjobs with a tty. If there were unexpected color outputs in the logs, that would suck since the log aggregators probably wouldn't know what to do with it.
QuickBooks Online or QuickBooks Desktop? Can’t tell from the docs.
> For example, trying to translate various terms in any given language from English usually causes inconvenience and confusion (everyone needs to know the localized version and then translate it back into English to find literature etc.). Therefore, it makes sense to teach everyone English.

Similarly, translating a lot of terms from German or Russian to English often causes inconvenience and confusion. So better learn German and Russian. :-)
T. Rex not as smart as previously claimed
I'm pretty sure I'm not getting paid 10x of anything.
The relevant comment is misinformed. The person they're referring to without naming is Irene Knapp, who left Google (presumably over her qualms). She's named in some press articles about the Google walkouts in 2020, e.g.: https://www.nytimes.com/interactive/2020/02/18/magazine/goog...
There are no details because it didn't happen and never would.
Your model assumes a even distribution of funds across society.
Will US Bankruptcy Court deal with a debtor that sells weed?
Warner Bros shelves finished ‘Coyote vs. Acme’, takes $30M tax write-off [0](76 points, 5 months ago, 104 comments)

[0]: https://news.ycombinator.com/item?id=38228644
That's horrific. You would hit another car or person every two years if not for automatic braking?

Also, it's inexcusable to turn in front of a pedestrian without even looking where you're going. I know it's common driving behavior but it's simply selfish to endanger someone on foot because you want to squeeze into cross traffic ASAP.
Assuming Americans live forever and get to enjoy their life, kids, family, and friends, and to live for decades youthfully after retirement, obviously the second!
> I used to have nightmares about the scene I saw there, but now I think of how great it is

So many people are not able to get over the grief (or fear, or guilt, or a hundred other emotions) that are usually associated with this sort of equipment, so they're forever seen as a sort of necessary evil - perhaps similar to military technology: something we know we have to have and have to develop, but not something we want to use, or embrace. I wonder if more people looked at these technologies and their potential applications with a bit more optimism, how things might advance.
Who do you think is going to pay for the retreats when all the high paying white collar jobs are gone? the economy will collapse which inevitably will affect you regardless of your job
I don’t think that’s correct. You can’t put up “future earning potential” as collateral while simultaneously allowing for discharge of debt in bankruptcy. That results in an incentive to incur as much debt as possible and then declare bankruptcy shortly after graduation when the impact is negligible. That’s the whole reason why student loans aren’t generally dischargable in bankruptcy.
I think if most disgruntled devs put honest thought into it like you did, they would reach the same conclusion, I certainly did, esp with a family.

I have also started to try getting more aggressive with investments
A quick glance at the React 19 Beta feature set
I usually flag posts like these after a scan through the comments, as even though the article is tech related, the comments on this type of topic are usually uninsightful, 90% of the time just being typical political/social echo chamber warfare, an excuse for people to post low quality comments shitting on the persona non grata, in this case, Elon. These types of topics on HN usually accomplish nothing other than increasing the hate in the world. If the comments don't follow that pattern I don't flag. But they almost always do.
Spam SMS is also an entrypoint into a target's phone for spyware/tracking purposes, eg Pegasus.

Perhaps the powers-that-be would prefer to retain that possible entrypoint, and thus have no incentive to resolve the spam "problem".
> systemd has been a net positive for the linux ecosystem. remember when you had to write bash scripts to start, stop, restart services and handle any other signals you want to send it?

Systemd was meant to replace Ubuntu's upstart, not sysv init. And it indeed systemd was better designed than upstart.

Sysv init is a horrendous hack. People should NOT use that. Upstart had limitations but is okay, and certainly much better than sysv init. Systemd is okay too (but has much more features).

Also as an historical note, both upstart and system was inspired by Apple's launchd.

NixOS was an early adopter of upstart but it later migrated to systemd (alongside Ubuntu itself)
Said no one on their deathbed ever...
> Apparently not, as per the study you linked to.

Follow the logic for the specific examples I gave, you will find studies where eggs are healthy/unhealthy and coffee is healthy/unhealthy

I provided a study that concluded there’s an association between raw milk and microbiome health resulting in positive physical/mental outcomes.

You clearly asked in bad faith, as I said generally raw milk is nutrient dense a significant source of fat, protein, carbs, vitamins and minerals. Unlike pasteurized milk that kills the good bacteria and enzymes, store bought milk removes much of the fat and adds sugar, it’s not the same product from a nutrient perspective.

Regarding the microbiome study, based on your objections, you wouldn’t be satisfied with any microbiome studies, nearly every microbiome study will be funded by a source you would find objectionable to fit your narrative whatever that might be, so I fail to understand your point besides being strangely argumentative on HN. Feel free to search the plethora of studies yourself.
As a UK resident who visits the US from time to time I was shocked by the cost of everything. In the past it's usually been cheaper than the UK. Now something basic like a mediocre sandwich bought in a shop is like twice as much as London. And when I bought my $8.50 sandwich in a shop in Austin and tried eating it I was followed down the street by a woman saying she was hungry would I give her some so I did and she really was hungry. In London we have beggars saying "I'm hungry" but they all just want money and are not interested in food. Something's not quite right.
Binance Founder Changpeng Zhao Sentenced to 4 Months in Prison
Did nobody else notice that this is a story based on sources "Familiar with the matter"?

Have we learned nothing from the Mueller Investigation? How are we all still falling for unsourced stories 5 years later?
I'm not a fan of sudo. It's does so much it needs BNF to describe it's configuration format. Who knows, maybe replacing the configuration with polkit is a good idea. Still it's a stand alone binary with one clear job to do, simple enough that one person has no trouble getting their head around it so it's not surprising it hasn't had too many problems over it's long life time.

This made me smile:

> sudo has serious problems though. It's a relatively large SUID binary, i.e. privileged code that unprivileged users can invoke from their own context. It has a complicating configuration language, loadable plugins (ldap!), hostname matches and so on and so on.

That is a bit rich coming from the author of systemd, which must be in the running for one of the largest bodies of code that must run as root. It's also a very complex piece of code. That complexity is the reason I was completely flummoxed by interactions between systemd and dll's being exploited by the XZ utils hack to attack an unrelated and uncompromised binary: openssh. Run0 is just an extension of that ball of mud. It's a stretch to believe it will be more secure than sudo in the long term, which is amusing because it appears Lennarts primary argument is it will be more secure.

I'm not the only one who has noticed this: https://lwn.net/Articles/971812/