skysight-inc/HackerNews huggingface dataset:
He is asking them, using the official power of his office, to do the right thing so legislation doesn't need to be drafted. Either they choose to do the right thing today and not be subject to regulations, or they can get punished with regulations at some point in the future.

If you think things happen differently in Canada, you don't understand how the sausage is made.
Adderall is used pretty effectively for this.
These kinds of rules are inane and self-defeating. Now instead of switching after the case begins, large corporations will switch ahead of time, as they do with email retention policies etc. Then not only do you not have the emails from after the case begins, you don't have the ones from more than 30 days before either.

Which has a negative impact on not just the case but the economy in general, because some of the information would have been useful to the company's business, but the managers will do what their lawyers tell them to do in order to not get prosecuted.
Adderall and Vyvanse?
Or potentially include the necessary context in the title of the post.
The post links to a prior implementation: https://www.reddit.com/r/JustGuysBeingDudes/comments/195gqnm...
where it shown being in a FPS video game.

Top comment there is: "The Pied Sniper" (!)

That clip appears to be from https://www.twitch.tv/deanobeano/clip/CharmingDoubtfulCattle...
(note: brief profanity at the end of the clip).
Global debt hasn't been this bad since the Napoleonic Wars
>You can solve that by altering the environment, the body, or the impulses.

Incorrect.

You patch that by altering the environment OR the body OR or the impulses.

To fix that you need to alter all 3
Which is unfortunate because any metric in a vacuum can be misleading regarding contribution to the aggregate.
There’s a pill form called Rybelsus that works similarly, but has some gotchas. Namely you need to take with water when you wake up and eat nothing for 30m.

From a lifetime value perspective, I think it’s priced cheap. This drug is a miracle drug and is going to eliminate a lot of suffering and healthcare costs.
I’m not familiar with this raccoon behavior but it sure doesn’t sound like it’s done without reason.

An LLM is never ready to react to anything because it’s just a matrix that needs a higher level system to invoke it.
Dad wants to work on a doc file, so why tf didn't OP install MS Word?
Taiwanese lathes are generally good, with some being truly excellent. The common Chinese benchtop lathes are best regarded as a kit of parts - they're crude, but can be made into a satisfactory machine with some fitting and fettling.
My doctor has been prescribing it for obesity for about five years.
Ollama v0.1.33 with Llama 3, Phi 3, and Qwen 110B
He would if he had broader congressional support, but opposing forces are strong (lobbies, pro-market ideology, etc)
"Impulses" here means the mind. Medication with side effects also effect the body. You're giving three options of altering the mind, body, or environment. On principle I'm against altering the mind and body of millions of people because their environment is shitty. This also doesn't buy anyone any time, it just makes it the new "baseline" normal as companies and society adapt around it like these snack companies you're saying take advantage of people.
Not a strong believer in LGM but I don't like your statement for two reasons:

1) life may take different forms, some of which we probably haven't even dreamt about

2) life is not necessary for inter-stellar probes to exist. In fact it probably makes more sense to make these things entirely artificial
8 ways I am using AI to help me be a better product manager
> But only Oyster cards can be used for PAYG within London and only ITSO cards can be used for PAYG outside London and store season tickets involving journeys outside London.

Jesus wept.
Dieselgate was about NOx emissions and avoiding using so much AdBlue. I'm not sure that a bigger tank for that would have a big impact. As it's happening in the exhaust system there shouldn't be an impact on fuel consumption.
BytePusher
Oh God, imagine the self-, peer, and top-down pressure to take that, both for students and working adults.
On the contrary, most weight loss doctors consider these drugs to be like statins. You take them for the rest of your life. The number of people who maintain healthy habits after stopping them is shockingly low.
"don't become an enemy of any state" which is a little trickier.
Show HN: I made an opensource tool to clean and convert any webpage to Markdown
I don't think it is, which is my point. It's essentially saying "I wish people with BEHAVIOR PROBLEM would do THING THAT MAY HELP MITIGATE PROBLEM." There is no statement of the size of that group, or how many people exhibit that problem. Unless you don't think the behavior being talked about is a problem (which is different than thinking not many people have this problem), then I'm not sure how having empathy towards them factors in. Is wishing they had more perspective and could avoid a cognitive pitfall not empathy?
It is called dexamphetamine. Or more more commonly these days, lysdexamphetamine.
You could buy the hybrid fossil i3 for many years, which was kinda the successor of the Audi a2, but better. Or also the electric i3 which was arguably better than the hybrid version if you have a charging network where you live.

I think it’s trivial to buy a better car than the Audi A2 nowadays. But not with an ICE.
> absurd to me the world has come to the point that we need these drugs in the first place

GLP-1 looks increasingly like a miracle drug. We see problems of addiction and obesity skyrocketing across the developing world. It’s not cost free, but it’s a hell of a lot better than the majority of America, China and India becoming potatoes.

When vitamins were discovered, there was similar moralising about there being no free lunch. With the benefit of hindsight those concerns were misfounded. Perhaps Ozempic has terrible side effects that haven’t been noticed since 2005. Given that timeline, however, we can confidently say someone obese taking the drug is better off with it.

> never cures it

I have friends who took it, lost weight and then stopped. The rebound was real but nowhere close to what they lost. (The lifestyle changes also mostly stuck.) For all practical purposes, their fatness was cured.

> when probably 99% of cases could be reversed naturally

Scientifically unfounded.
sure, for each arch.. or just use the thing that the tool is designed for as the distribution mechanism. A `docker run ...` is one step, not the two you're advocating.
The worst case is worse than that: in addition to composition of matter patents there are dosage patents that can be invoked.

https://www.fiercepharma.com/pharma/novo-nordisk-patent-sema...
these cars should be "sucker cars" with active downforce and cornering Gs exceeding human limits... then I'd watch.
"Sounds really bad" is orthogonal to "is really bad".

There's a heuristic that goes, "Shortcuts will catch up to people eventually," but I'm ok with letting the evidence bear that out.
that would actually be cool, and an useful use of captchas, for once.
Rybelsus is available in tablets and costs €130 in Spain.
If all signs in the prison camp were written right-to-left instead of vertically, they probably would have noted that before creating the sign. Especially considering their lives depended on it.
Trade was the engine of growth for decades. Now overall debt is approaching the world’s total economic output. It doesn't look good.
Hey don't worry, your fears are mostly unfounded -- GLP1 Receptor Agonists have been an effective treatment method for type 2 diabetes for a very long time. They're well studied, researched and trialed, at this point, and many side effects are known.

I'm a bit biased of course (I do a lot of trying to keep up with the research and effects of GLP1 drugs), but I honestly don't think the weight loss scene has seen something so effective and safe for a very long time.
Indeed, we should charge the parked driver for the cost caused by all those passengers in buses held up. They are getting off cheap with the ticket.
The fact that fuel prices is the US are like 2.5x lower than Europe may also have contributed to the oversizing trend.

You would think twice about gratuitously moving around a multi-ton behemoth if it actually hurt you economically.
> You don’t maintain your own ultra expensive space industry for any other reason.

Except the kind of rockets they've been designing would make for terrible ICBMs. Take for example the recent H3 a hydrogen powered booster. For weapons you want solid or maybe hypergolic propellants that can be stored and ready to fire for long time periods. Liquid hydrogen would be an awful choice for that.
> So it scares me a bit when something like Ozepmic pops up and tons of people jump on it, without knowing the long term effects that might appear.

Test in production. YOLO!
I think you heavily overestimate our capabilities to detect (even large objects) entering the solar system.
Also, why do you assume there would have to be life present on-board?
There's a second "myth" that you could have recognized it was the wrong decision at the time. And that's not always true either.
Many Americans seem to have been told they need to drive a tank-like car to be safe. I point out that the tank is safer in a crash, but a smaller car may be able to stop in half the distance and avoid the crash altogether. I am assuming that its safer to focus on avoiding a crash than surviving it, but maybe I am wrong. Certainly it would depend on the driver. If you want to text on your phone and not maintain distance with the car in front than the tank approach is probably safer for you (but dangerous for everyone else).
When I took Ozempic I had these side effects:

* Low libido and erectile dysfunction
* Constipation, diarrhea, and extreme bloating (burping all night long)
* Often difficulty sleeping. Waking up a lot. Very restless.

We need a drug that doesn't slow digestion but decreases hunger and increases satiety.
And what are movies except for coordinated, flashing lights and a paper cone being shaken real fast?
You may find also interesting the projects at ucapps.de, and on the commercial side, the Elgato Stream Deck which has FOSS support.

http://www.ucapps.de/

https://www.elgato.com/us/en/p/stream-deck-mini

https://github.com/streamdeck-linux-gui/streamdeck-linux-gui
> doesn’t sound like a sustainable lifetime solution

Would you same the same thing about insulin or statins or even caffeine? Why couldn’t something like Ozempic be something you take long term?
Can't wait for 2034 Goldman Sachs report: "Can we sell cocaine to toddlers?", "Can we re-lead the water? People are too smart anyway"
I made a simple tool to scrape any webpage and clean it so that I can drop it to our blog easily (part of our newsletter workflow)

I previously posted this[1] and there was a common ask to open source it so here it is.

1. https://news.ycombinator.com/item?id=40033490
MDE plan 2 is no assurance of security. There was an incident where Microsoft, in their infinite wisdom, pushed out definitions that caused the removal of many valid app shortcuts freaking users out that all of their apps were deleted. This is not an isolated incident. MDE makes sweeping changes to millions of machines that Microsoft appears to barely test at all.
Unless that's a false dichotomy. Obesity can be treated in less harmful ways. Companies can be regulated into only including a safe amount of sugar in drinks and foods that arent considered sweets
In my case, I am applying this in the calibration of instantaneous correlation matrices. His relevant papers can be found at [0].
It was really helpful that he also published MATLAB code of most of his algorithms.

[0] https://nhigham.com/correlation-matrices/
pretty sure i can do that in KDE using the gui, in the system-config/keyboard :)
and it's saved in my home, because my /usr is immutable
I’m not sure I understand your point. Vapes and e-cigs are less dangerous to your health than regular tobacco cigarettes.
Thanks, I've read it, don't remember the lathe in it. Awesome book. So much better than shogun or any of his other works from his "trader series".

I recommend King Rat to people who need to get back in to reading books.
Some photos from the camp here: https://www.rnz.co.nz/national/programmes/eyewitness/galleri...

Photo of men with artificial limbs built in the camp: https://www.awm.gov.au/collection/C4416

A wireless set hidden in the sole of a prisoner's sandals: https://www.awm.gov.au/collection/C14187
Maybe take a loan, if you want to buy an apartment that is, and enjoy your life.
Practically fool proof. A net positive for society.
It's 88 EUR/month in my EU-Baltics country. I'd say it can be made much cheaper here and therefore in the US as well.
1000 a month per patients will handily fund an awful lot of high priced lobbyists. Such congressional proclamations are arguably just a clarion call to K Street
No, not at all. While I think we have a pretty fantastic drug approval process (that got a frustratingly bad rap for all the wrong reasons during covid), long term consequences will remain to be seen.

It's just that these considerations run up against a very solid understanding of how much death is caused by being overweight and having high blood pressure.

Right now, Ozempic does not have to be very good, to be most likely a lot better than the alternative.
How is this dystopian? Dystopian would be if we ticket cars based on how likely they might park in the bus lane.
California is also going negative quite often now. Instead of dropping prices and encouraging usage during those times they curtail. The utility model is completely broken.

https://www.eia.gov/todayinenergy/detail.php?id=60822
The actual report (not linked to by CNBC of course) says

The potential to deliver “one shot cures” is one of the most attractive aspects of gene
therapy, genetically-engineered cell therapy and gene editing. However, such treatments
offer a very different outlook with regard to recurring revenue versus chronic therapies,
particularly in certain diseases where it is possible to cure a large proportion of the
prevalent patient pool (or at least prevent an additional dose from being required for an
extended period). While this proposition carries tremendous value for patients and
society, it could represent a challenge for genome medicine developers looking for
sustained cash flow. GILD is a case in point, where the success of its hepatitis C
franchise has gradually exhausted the available pool of treatable patients.
We highlight several potential solutions for these genome medicine companies to
sustain an attractive profile.
Solution 1: Address large markets: Hemophilia is a $9-10bn WW market (hemophilia A,
B), growing at ~6-7% annually. We estimate that the hemophilia A market currently
represents ~$6.5bn, while hemophilia B is ~$1.2bn.
Solution 2: Address disorders with high incidence: Spinal muscular atrophy (SMA)
affects the cells (neurons) in the spinal cord, impacting the ability to walk, eat, or
breathe. It is the leading genetic cause of death in infants. SMA affects ~1 in 11k
babies, and 1 in 50 individuals in the US is a genetic carrier. Cancer is also a sustainable
market given the patient population is almost entirely incident driven.
Solution 3: Constant innovation and portfolio expansion: There are hundreds of
inherited retinal diseases (genetics forms of blindness). Once a gene therapy is
approved for a genetic eye disease, the validated platform could be used to quickly
develop many more eye-based gene therapies. Pace of innovation will also play a role as
future programs can offset the declining revenue trajectory of prior assets.
Digital ad market is finally bouncing back from the 'dark days' of 2022
It probably wouldn’t have much of an impact on the sales or marketing of this product, but it’d definitely have significant impacts on drug manufacturers’ future plans (by reducing expected ROI & discouraging the development of ‘marginal drugs’).
But that's the whole point -- that most news doesn't happen during trading.

That you have ample time to digest the news from overnight to trade in the morning, and ample time to digest the news from the day to trade at the end of the day.

There's definitely importance for prices to change daily in response to news. I'm questioning any economic or societal need for prices to change by the second/minute, or even hour, in response to news. All it does is funnel some extra profits to professional traders who watch the markets and are subscribed to every news alert, and disadvantage everyone else who just stays on top of industry/market news like a normal person.
There’s a reason it reads like propaganda. The guy is just talking his book. From his other site (located at the domain used in his email address):

> Phantom Plastics offers polymers & plastics consulting services and custom solutions for your polymer and plastic industry challenges. Companies like HP, Apple, Exxon, P&G, iRobot and Disney turn to Phantom Plastics for help. Why? Simple! Phantom Plastics® provides world-class solutions quickly. The polymers and plastics consultancy services we offer can be applied throughout a product development process, or when a specific issue arises. If you have a tough problem or need a breakthrough material solution, then the leading plastics consultant is just a phone call away.

Truthfully, I think plastics are a pretty remarkable product, but I think these arguments would have been a lot more compelling if it had been framed in that way — rather than this (frankly unbelievable) persona of, “I’m just a simple man who loves science and reading papers and here are these incredible findings in which I have no vested interest in whatsoever.”
You're confused. It refers to the price of all available shares. We don't say "The size of Meta shrunk in one day by 20%" because the share price fluctuated. That would be retarded. No one refers to the 'size' of a company is referring to market cap.
There are dangers/risks to buying pharmacy compounded semaglutide -- not really a great thing to recommend widely. It's hard to depend on whatever pharmacy people might be able to find locally or through some hopefully trustworthy portal.

That said, with China and more notably India entering the GLP1 RA race, there will be much cheaper options very soon, hopefully!
How do you know of this? This is really cool
We might never retire but at least we’ll grind out leetcode in our 60’s while on adderall, ozempic, lions mane etc…and won’t feel a day over 55!
Pro 11 is still subject to bullshit ads. Prefer 11 Enterprise licenses so that ads can be completely turned off.
One thing that isn't often mentioned is the diversity of the US landscape. For those who go hiking or even straying off the common road, having high ride height is desirable, which suits large SUVs perfectly.
Market cap refers to perceived value to shareholders as measured by the stock price, which may or may not have anything to do with the size of the company or the amount of profit that it's making.
Not to belittle your situation, which I know nothing about, but there’s nothing unusual about living very modestly the first few years of one’s career.

May I ask how old you are?
Currently they cannot manufacture enough to cover demand at $1000/ month. Why would the price come down before they can supply current demand?
I’m reminded of the bit in 1984 where they’re trying to remove the pleasure from orgasms. I don’t entirely disagree that this would be good to make accessible but removing the joy from eating is so bleak
Carmakers build what sells.

So what went "wrong" is that people prefer powerful cars with plenty of space, comfort, and bells and whistles rather than "3l/100km"...
The mistake is Canada, not FAANG. Essentially no career choice pays enough to afford RE in Canada without supplementation. I recommend moving because things are going to get much worse before they get better.
> You don't build modular synthesisers out of MIDI.

Yes you can. I do
Unless it's dedicated to a certain aircraft type, that mostly makes sense, otherwise the jetbridge section between doors would have to accordion to account for the length of the plane.

I don't recall like that, but there are also double decker jet bridges to board both levels of the A380 at once.
No, when someone does not make a lot of money, the answer is not “get a loan.”
Yeah that's the kind of folk wisdom that causes people with psychiatric conditions to stop taking their medications. It's very ignorant and harmful.
The answer is a resounding no. The rankings speak for themselves.

https://data.worldobesity.org/rankings/
These are some interesting side effects -- I'm not sure I've seen low libido very commonly -- have you noticed any other reports/disclosures of that sort of side effect?

Note that GLP1 RAs do decrease hunger, and their effects are very much also psychological. It's not simply a digestion slowing pharmacological effect.
> [...] has become increasingly difficult and expensive to maintain as parts become obsolete.

not sure obsolete is the right word?
Has anybody any use for, or used, MIDI 2?
wish they'd ticket traffic violators, not just parked cars. Cars running red lights, cars driving in lanes they aren't supposed to be in. Cars turning in places that are illegal to turn at. Cars speeding. Cars stopped in crosswalks. I see these daily. I'm happy to submit camera footage if it means tickets and enforcement.
Captchas, at least recaptcha which is the main image selection one, exist to enforce Google's browser monopoly and force tracking on you. You're not proving you're a human, you're being punished for not behaving how google wants. It's vile.
$947 in the US, LOL.
You clearly don't know a lot of people who aren't wealthy. The majority of people I know couldn't spend 10k on anything except absolute necessities, let alone a car. Of those who do have vehicles, none of them spend $10k/year and if they did it would damn near break them.

Seriously, I don't mean to be rude, but god damn this is out of touch for people who are struggling.
The Apple Vision Pro's eBay prices are making me sad
Sure but that's not the point. Reduced fuel consumption using hybrid technology works in the city. EVs are even better.

It's just fascinating that the technology was there and wasn't improved upon in 25 years. We could drive non-hybrid ICE cars were a big chunk of cars is using 50% less fuel now if we would have avoided that SUV trend.
$10k/yr on a car is not incredibly high

https://www.edmunds.com/bmw/x3/2022/cost-to-own/
Exactly.

Let‘s say you have:

1 contactless bank card, 1 iPhone, and 1 Apple Watch

These count as three different cards and would therefore allow you to pay for your own fare and two additional people.
Keeping prod stable is more important than alpha testing every team's latest commit, but monorepos tend not to accommodate staying on known-good versions of your dependencies and opting into updates when ready.
> To fix that you need to alter all 3

We have tons of evidence to the contrary in multiple disciplines. Like, have you never made a conscious dietary change?
This is the drug dealer argument; if it wasn't me, someone else would
> Who spends 10k/year on a car, that seems incredibly high.

You may need to recalibrate your intuition. Average payment on a new car purchase in the US is almost $9,000/year. Average used car payment is >$6,000/year. This is before taxes, insurance, gas, etc. It is common to spend $10,000/year on owning a car in the US.

The Americans who don't spend a lot of money on car-related expenses are the outliers. Despite this, the median American household still has $12,000 per year leftover after all of their ordinary expenses like paying for cars. Average Americans have high incomes, profligate spending patterns, and poor savings behavior.