skysight-inc/HackerNews huggingface dataset:
No it’s the exact same drug. There’s no “without glycemic control” difference. The largest dose of Ozempic available is a little more than the largest Wegovy but it’s the same drug.

I’m on Ozempic and not Wegovy. Here’s why:

- Wegovy is impossible to get. I had it prescribed a year ago and it still hasn’t been filled. Multiple pharmacies too.

- In the meantime, my new insurance doesn’t cover it or Ozempic. So I’m out of pocket.

- Ozempic 2mg pens are readily available and unlike Wegovy, you dial the dose, so that 2mg pen lasts me 2 months. It’s not officially indicated and they tell you not to, but just google an Ozempic click chart to see. My doctor was the one who suggested this!

- Wegovy pens don’t have variable dosage. Only Ozempic does.

- Theres no price difference in the pen sizes for Ozempic or Wegovy near me. No matter what dose pen you get, and no matter if it’s Ozempic or Wegovy, it’s $1000 for a 4 dose equivalent of the prescribed amount.

So for me it’s a no brainer if I’m paying retail - give me the highest dose Ozempic pen and I’ll dial the smaller dose that I take. It’ll last me twice as long since I take 1mg weekly. And I can actually get it.

The fact that 0.5, 1, and 2mg dose pens all cost the same tells you how badly we’re getting worked here.
Different people place different weights on different values and outcomes. I'm sure there are many elderly people who miss the culture of sociability with neighbors that was largely a byproduct of material scarcity. Borrowing the sugar, congregating at the neighbor's house who is the only one on the block with a TV, etc. Our loneliness and mental health crisis is largely the price we paid for vanquishing material scarcity.

If you cannot see the dysgenic effects of vaccines, antibiotics, etc I doubt I can convince you in a a single comment. Just take my word for it that the percent of the population that will have permanent defects that require lifelong treatments is continuing to rise. Sperm loads and quality are continuing to drop.

I am not implying that these trade-offs aren't worth making -- just that our collective leadership should be making them with eyes wide open and planning for the inevitable sacrifice each piece of 'progress' requires.

Edit: Just as a simple thought experiment: If these obesity drugs are really the miracles they seem to be, I can see a future in couple generations where any disruption in supply will lead every single person to balloon to the size of the fattest person you have ever seen in your life. What ever gene(s) are regulating satiation will be rendered moot and thus have zero selection pressure. The outsourcing of this function is just that -- the human organism will no longer have any method of regulating hunger, satiation, etc.
i am remote since 2010. I used to love to go to the office each 3 months, spend a week there. Now office is empty, company decided to down-size it, moving to another place and people go just to office in Summer to abuse the air-conditioning.. It is said that we lost the office, which use to be the place where we used to build a strong team spirit and have important discussions or team events..
> Every episode kept adding more "mysteries" and ending on increasingly ridiculous cliffhangers until it got cancelled without explaining anything.

While also getting more and more slow and labored. That's why I stopped, yeah. But I'm also a completionist.
Calling this backdoor "vulnerable code" is a gross mischaracterization.

This is closer to a large scale trojan horse, that does not have to be randomly discovered by a hacker to be exploited, but is readily available for privileged remote code execution by whoever have the private key to access this backdoor.
> (Yes, I'm very aware of rms and the FSF.)

rms and the FSF believe selling software is totally fine as long as you provide source code to your users.

They don't think there's any moral imperative for software to be free as in priced at $0, but software should respect its users' freedom.
I really appreciate your tone and dialectic reasoning, thanks for your reply. And yes, as simple as it sounds, I believe that shell scripts help a lot to maintain mission critical tools. One hands-on example is https://dyne.org/software/tomb where I took this approach to replace whole disk encryption which is nowadays also dependent on systemd-cryptsetup.
CFAA covers distribution of malicious software without the owners consent, the Wire Fraud Act covers malware distribution schemes intended to defraud for property, Computer Misuse act in the UK is broad and far reaching like the CFAA, so this likely fall afoul of that. The GDPR protects personal data, so there's possibly a case that could be made that this violates that as well, though that might be a bit of reach.
The P in VPN has been perverted long time ago.
Used to use that as well, but the selection was too limited for me, so I first switched to chocolatey, and nowadays, winget.

This way I can install almost everything I want with one command.

I'll post my list tomorrow when I'm back on my PC.
Nope, that's my pure speculation.
Related: https://news.ycombinator.com/item?id=36511948
gzipped.
> Which is basically the same drug but without glycemic control

No... The effects are the same because they are exactly the same drug (semaglutide), the difference is the dosing schedule and max dose (wegovy is 2.4mg and ozempic is 2mg).
Yes, I didn't remember a continuum between SF and GitHub but the obvious demise of SF et al (Greshmeat, Slashdot, etc).
Drogo- Games,Live Stream,Chat
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Flipping a Rusty Coin
I do get that point, but I'm not sure it would actually work

Drug prices in the US are, in part, higher because FDA requirements are much, much stricter so it's more difficult to actually get a drug approved. It's simply more expensive to launch a product in the US, so if it becomes less profitable it might not be worth the risk for companies

You could also risk that drug companies launch an analogue of the effective compound in the US to circumvent such a regulation, since it would be two different drugs

The reason it's cheaper in Europe is in some part due to having single payer healthcare, which mean that there's a single entity negotiating purchase prices for the entire country, which improves bargaining power significantly
>> Is this a problem or a strength?

I was wondering the same thing. I understand, why the initial developers of this method declared it as a strength. Still I think it's a problem, too:

If the Tranformer reads this sentence:

A equals B

It understands, that B comes after A and therefore A equals B. But how does it learn that after A comes B and therefore B equals A.

I am referring to the logical problems, that most (all?) modern language models suffer of.
Next up: he learns how to slice bread.

But seriously, why is this news worthy? My grandmother showed me how to do this way before this guy was even born.
specifically, thevCFAA covers distribution of malicious software without the owners consent. Security researchs downloading malware implicitly give consent to be downloading malware marked as such.
Can vouch that this is a nice piece of software, especially the batch convert options (everything from EXIF data, rescaling images and various other transformations, as well as either replacing the original files or various naming options) and supports a bunch of formats.
It is like opening the door of a safe and letting someone else rob the money inside.

This is way beyond "moral level".
I find that LED bulbs have a much higher failure rate than advertised, even though I am buying a selection of what I think are quality brands. (Strangely, the only kind I have not had die are some weird Chinese brand I can only find on Amazon.) I haven’t done the math but given I’m replacing at least one bulb a month I’m skeptical the efficiency makes up for the price, especially since I prefer 100w equivalent bulbs.

Maybe my power sucks but I don’t have this problem with incandescent and that’s what consumers care about. I have power filtering for my desktop though and the reporting doesn’t show any issues. CFLs were much worse, I’m glad those are done with. It feels like I’m paying more for inferior quality.
If you’re only changing your duvet cover once a month (or less) you’re sleeping under a sheet under the duvet, right?

We don’t do sheets and are in the change once a week camp.
The situation described in that Lancet article doesn’t seem very subtle.

And if the US is able to impose maximum pricing that is so much lower, it would seem likely that price gouging was occurring.
If more than one person was involved, it'd presumably fall under criminal conspiracy. Clearly this was an overt act in furtherance of a crime (unauthorized access under CFAA, at the least).
OS Basics (Featuring iOS Springboard)
Thanks, but you assume too much. I outlined the circumstances under which i would require a background check, so you might want to reread. any other questions?
You use the C and C++ approach to all their design flaws and reach out to a static analysis tool that covers such cases.
He didn't design anything, he started by putting together PC upgrade kits.
QubesOS is amazing! I've been working on QubesOS for several years. When it was just starting out, it was a fairly simple solution, but now it's a big software, and it has just as many problems as any Linux distribution. Complexity is the only parameter by which you can determine the amount of malware. For 0 bytes of useful code, there will be 0 backdoors. I also developed ACPU OS for this reason 12 years ago, but later realized that no one would pay for simplicity.
And now decoding a jpeg takes the blink of an eye, but we wait five seconds for a widget to render. When it does, we click somewhere else, because in that exact moment the layout was reflown.
tl;dr: https://www.youtube.com/watch?v=DRPfudNNd8Y
> But why would a government want to own tons of random Linux machines that have open sshd mappings?

They don’t want tons. They want the few important ones.

Turns out it was easiest to get to the important ones by pwning tons of random ones.
Yeah that's almost every drug so what
The LLM part is almost irrelevant to the final result to be honest: I used LLMs to help me build an initial prototype in five minutes that would otherwise have taken me about an hour, but the code really isn't very complex.

The point here is more about highlighting that browsers can do this stuff, and it doesn't take much to wire it all together into a useful interface.
This is not a western parts thing, just one guy discovering something most consider common knowledge here.
I've got a job for you, mine at my previous company!
IIRC, Wireguard is exclusively managed by Tailscale clients, and not by the server (headscale in this case).
There is no encoding that would shred "any" (read: every) trillion bit sequence. If that were true, some fundamentals of information theory and compressibility would break down.

Lossless encoding works by taking advantage of the more commonly observed sequences of data having lower information entropy. For things like audio encoding, where discontinuous sequences aren't naturally observed (or pleasing to listen to), lossless encoding has a lot to work with.
> There is an awful lot of sympathy for the drug company in this thread.

And for good reason.
This seems to assume that KC can be infinite. That must have been proven at some point? Otherwise it may be that there is some upper-bound for L which happens to also be the KC for a KC-computer.
> the 32-bit to 64-bit transition

Lzma is from 2010. Amd64 became mainstream in the mid 2000s.

> removal of pre-C89 support

Ibid. Also, at the library API level, c89 compatible code is still pretty familiar to c99 and later.

> new architectures like RISC-V

Shouldn't matter for portable C code?

> the increasing amount of cores and a slowdown in the increase of per-core speed,

Iirc parallelism was already a focus of this library in the 2010s, I don't think it really needs a lot of work in that area.
> As discussed in Mozilla's wiki page on blocking media autoplay, the default setting for this preference allows autoplay once you've interacted with that tab,

I despise this idea with a burning passion. It means that the instant you scroll down the page, or bring up a menu, or "interact" for some definition of the word, BOOM! some obnoxious video starts playing.
When people complain about being forced to pay thousands a month for insulin, they're talking about the newest synthetic insulins that were developed very recently at substantial costs.

They could take the older insulins for $50 a month, no one is stopping them. It's just that those older products are less convenient.
Completely agree. That's part of why Ozempic is cheaper in Europe. I actually worked for the company who negotiates drug purchases for all hospitals here in Denmark (Amgros), so I'm somewhat familiar with the process

There's flaws in this approach as well, but in the end it's definitely an improvement to the issues US patients are facing in regards to costs
this is the conundrum the US Pharma is facing. GLP1 took NN 10+ years of investment to come up. Acquired podcast has a great story about them. The middleman is what is different between the various country healthcare systems. USDOJ is trying/tried going after but one word - lobby. The regulation required is for consumer to directly buy from pharma skipping all middlemen. my 2cents.
Exactly. It’s always so crazy to me how there’s such a double standard when it comes to art. Millions of people spend their entire lives in factories doing the same stitch over and over again, but if Kubrick makes Shelley Duvall do the same scene 100 times it’s abuse. How many people die in the shipping industry for example and no one calls them out
If those proteins are mutable and have an impact on child cell function, I'd call that memory :)
The Fafsa Fiasco Is a Big Deal
That's a really weird loss of service.

land lines are the ones that depend on large-scale infrastructure, and go out with any natural disaster. Cellphones should be much more resilient.

Anyway, the current solution for emergency communications is satellite. We have nothing more resilient than throwing things up there above the atmosphere.
https://archive.ph/thrFs
If the payload didn't have a random .5 second hang during SSH login, it would probably not have been found for a long time.

The next time, the attackers probably manage to build a payload that doesn't cause weird latency spikes on operations that people wait on.

(For some reason this brings to mind how Kim Dotcom figured out he was the target of an illegal wiretap... because he suddenly had a much higher ping in MW3. When he troubleshooted, he found out that all his packets specifically got routed a very long physical distance through a GCSB office. GCSB has no mandate to wiretap permanent NZ residents. He ended up getting a personal apology from the NZ Prime Minister.)
> Living in a poor or lower middle class outer suburb and commuting by car is slower and hundreds of dollars a month more expensive than living in the urban core and taking public transportation.

Totally. Because it's wildly inefficient for everyone to own an average 0.8 $35,000 blocks of metal that are in motion an average of 1.02 hours per day (idle almost 96% of the time). That requires roads, lights, signs, police, fire trucks, ambulances, gas stations/charging ports, insurance, parking, registration and tracking, maintenance, etc. That's before we get to externalities.

Yes it's hundreds of dollars more expensive to have a car, but it should be thousands. It's incredibly subsidized. Car owners have been massively over-served, and it's time they directly paid the actual cost of their choices.

Car ownership should be a luxury, not a requirement to exist. Especially in lower-middle-class suburbs. All our investments into roads and highways should be redirected towards avoiding it. All parking should be for-pay. Road costs should be born by road users. And yeah, people who make inefficient choices about their transportation should be penalized by usage charges.

What makes you think road users have been underserved relative to the literally zero investment in transit made in the US since Eisenhower?

Why shouldn't the cost of a dramatically less efficient transportation choice be much higher than a much more efficient transportation choice?
Another thing you can do when you have two versions, one which fails and one which doesn't, but where the commits are of the messy work in progress nature and not atomic changes, is gradually stage the changes from the bad version onto the good version until it starts failing

Basically git checkout -p until things fail
I wonder why nobody introduced a "Accept-Max-Size" request header?

Chrome is toying with custom accept header[1] types but they're used by servers to request information from clients, which is completely missing the point in my opinion.

[1] https://developer.mozilla.org/en-US/docs/Web/HTTP/Content_ne...
Niche things by definition are less popular. In my grandparent comment I was explaining why standalone image viewers are less popular. Looks like we agree.
You had one job, browser "never auto-play" setting....
>Even after that, you were still insisting there were loopholes.

After clarifying my position, I figured you'd either reply with "yes, we were on different wavelengths" or you'd accept we were talking about possession. So when you continued, I assumed you were talking about possession too. My mistake.
> Also, it's not like you can bootstrap yourself or grow organically like Startups.

So if they have a effectively built monopoly, chopping down the maximum they can charge via regulation would seem sensible wouldn’t it?
That intuitively makes sense to me.
A cell phone that’s always placed in its charging stand except when in use is indistinguishable from landline. There’s no “forgets to charge it” or “loses the charger”.
Pretty weird diabetics have a lower dose
A software project has the features it implements, the capabilities it offers users, and the boundary between itself and the environment in which those features create value for the user by becoming capabilities.

The "accounting" features in the source code may be finished and bug-free, but if the outside world has changed and now the user can't install the software, or it won't run on their system, or it's not compatible with other current software, then the software system doesn't grant the capability "accounting," even though the features are "finished."

Nothing with a boundary is ever finished. Boundaries just keep the outside world from coming in too fast to handle. If you don't maintain them then eventually the system will be overwhelmed and fail, a little at a time, or all at once.
At least in my country, cell towers are numerous and get an equipment cabinet about the size of a fridge; telephone exchanges are one-per-city and the size of a small office building.

Much easier to provide a generator for the latter.
A question: why include a timestamp? Why not just 80 or 128 bits of pure randomness---if somebody needed a timestamp they could always just append it themselves. And, it seems to me, there would be many instances where you didn't need or want the timestamp.
It's because those other countries are free riders.

I think we should do the same thing in reverse on limiting CO2 emissions. How does that sound?
I just checked out your website and played Biolab Disaster. A new version for NES would be great
The NDP have forced the current Liberals to pass two of the most impactful programs in a LONG time: universal dental coverage and now pharmacare.

They may be floundering in the polls, sadly, but their impact has been immense.
much better with this advance technology
Yeah I find the rolling method is more work than it’s worth when the “grab the corners and shake vigorously” method works just fine.
> EDIT: This is just a lenticular sheet.

If it's done right, it'll be more like a fresnel lens.
I really enjoyed that. Perfectly fits my mood :)
The rolling method is really exactly the same thing, but some people find it easier to think about reaching in for the corners after rolling, and you don't need to be tall enough to let it fall down into place (wife is 5'4" and rolls, I'm 6'4" and just reach for the far corners).
Tiny orchid flowers pollinated by tiny flies
Should they not profit on that capital invested for that research? Do landlords drop rents when the loan is paid off? Of course not, they’re going to price rents what the market supports. Competition is what makes markets work. Invent a drug? And someone else invents a similar drug? Prices will go down.
It’s not just a matter of commitment with hobbies either. I like Dream Theater and I play electric guitar. But try as I might I will never even come close to John Petrucci. It’s not even physically doable, although I’ve gotten pretty decent over the years. Whereas in my professional life I _am_ at the top of the food chain if I want to play ball. I just sometimes struggle to find an interesting game to play so to speak.
> NSA is the biggest malicious actor

I'm curious, how do you rank CN, RU, and IR?
Genetic causes of cerebral palsy uncovered through whole-genome sequencing
> I don't need autoplay.

I don't need it. I don't want it. I try to disable it. But the setting either is ignored or simply doesn't work.

When and why did browsers give up on reliable autoplay blocking?
The effect of the slowdown on the total handshake time wouldn't work well for detection, since without a baseline you can't tell if it's slow due to the backdoor, or due to high network latency or a slow/busy CPU. The relative timing of different steps in the TCP and SSH handshakes on the other hand should work, since the backdoor should only affect one/some steps (RSA verification), while others remain unaffected (e.g. the TCP handshake).
NN didn't come up with GLP1. It's a natural peptide, and people have been taking it for a very long time. Nordisk did get it approved, yes, and that was costly, but let's not massively overstate the innovation.

Semaglutide is not GLP1, it's a bit different. But it's not the first GLP1 analog. It's not even the first to be approved : AstraZeneca was the first to get a GLP1 agonist approved, in 2005. In fact, it even is used off label for obesity.

Nordisk's big break was convincing the regulators to get it approved for obesity and not just type 2 diabetes.
Scientists discover a key quality-control mechanism in DNA replication
you'd be surprised but reddit is mostly shills.

besides your anecdote, all the games reviews, computer part reviews, etc are all paid by drop shippers. and some reddits like mattress review ones are exclusively shills talking among them.
I hope that you never have to take care of an aging parent with dementia.
cool ideas, let me try to make them real.
All that could change if BeOS adopts systemd.
I wasn't even aware duvets were still used outside of hotels. You guys don't just have sheets and a regular blanket on your bed? Is it a cultural/regional thing? They seem very annoying to deal with and I've never found them to be particularly comfortable, so I'm surprised so many people here seem to use them.
That still implies there was a target in mind. But also they would've had to assume the access would be relatively short-lived. This means to me they had something specific they wanted to get access to, didn't plan to be there long, and weren't terribly concerned about leaving a trail of their methods.
New cataclysmic variable discovered by astronomers
I couldn’t find the post, but there was a more recent post (I think it reached the hacker news front page) about how just about every LED bulb has significant blue emissions.