skysight-inc/HackerNews huggingface dataset:
All drug research and production should just be done with public money by the public sector. Drug companies are already deeply reliant on university produced researchers and research, and in most cases the actual drug production is trivial. Imagine the human and economic benefits if there was no profit barrier to health.
Didn’t Bezos leave a hedge fund?
I'm with you except the part where you say to "simply go in." I see no reason why I should go in. The aggravation of interacting with a dealer is not worth the pennies I might potentially save (but only potentially, and only if I do everything perfectly, and at the risk of losing my shirt if I mess up even slightly).

I want fixed price transactions. Dealers do not give this to me. Tesla does. Therefore, I go with Tesla. You don't have to. But you can't, and you shouldn't, advise me to do something that I plainly dislike doing. I have already made it clear that the money is not the issue, it is the principle behind the thing. Lack of fixed pricing is the precise thing that I find objectionable.

If a dealer, or anyone else, gives me a different price depending on my method of payment, then I am not going to be your customer. Full stop. I'm not going to try to game your pricing. I want to know that you are engaging in this practice, not so that I can exploit it, but so that I can avoid it.
We already have our own tools for that, either integrated into screen readers or available as add-ons. Thanks for the thought, though.
That is a great book on the subject — the authors have published some important work in this area in papers as well.
Nano-oscillator hits record quality factor
Which part do you disagree with? Both sides host and support people that will readily lie to defend their own entrenched position. I'll agree any day of the week that Hamas has the more draconian social policy, but that's not an excuse to write off Gazan journalism.

Israel's flaw is theocracy, which does not inherently equate them to their enemies but tragically condemns them to a similar path. Their army is stocked with religious adherents and their population is seeded with nationalist migrants. They're bankrolled by a foreign power that ensures their competency but one that doubts their altruism when acting independently. In effect it's a proxy war of chicken, with hundreds of thousands of innocent civilian lives caught in the middle.

That part I hate. The only thing I'd be willing to concede is that journalists are being suppressed domestically, even though journalist casualties in Gaza suggest a staggeringly different story. In lieu of direct evidence I'll shelf that, but still contend the rest.
Thanks for the comment! It looks to be a very useful tip for doing after bisect on repositories where people insist to squash pull requests.
I literally laughed out loud when I read this and that actually pretty much never happens despite sending LOL in text messages.
I vary it based on if the cover came out the machine inside out or not.

If it did, I spread out the duvet, burrow inside the cover, grab the far corners of the cover from the inside and then through it also the corners of the duvet at the same time, and invert it.

If it came out the right way round, I spread out the cover, grab two corners of the duvet, burrow inside the cover with the two corners of the duvet until they reach their destination, and come out again.
The lancet 'article' doesn't actually say anything. It's just a political hack job.
This is why I've never bought into the idea of "ecosystems" for tech products. Pay $10 for a DRM file on the Amazon and still have to put up with ads.
Of the three, ditto easily takes no. 1 spot. Must’ve saved me weeks of juggling windows and trying to remember where stuff was at this point. It’s a superpower, a true game changer if I ever saw one.

Maccy on macOS is about half as good which is still an absolute unit of a tool. Couldn’t use a Mac without it.
> There a few new remixes or interpolations every year. Some ask first, and some don’t. The last one to ask permission was the artist Pink, who I love

Is Pink's remix publicly available anywhere?
when the reference count can only be zero or one reference counts have different performance than when it can be more, and it is much easier to reason about. This is most cases.
Yeah, Irfanview dates to a time when MS’s C compiler was horribly out of date (still stuck in C89 compatibility), and the only way to get remotely modern language features was to compile it as C++, even if you never used any C++ features. Everyone was programming in “C++” on windows back then even if they were basically writing C.

So yeah, it’s C++ but that doesn’t necessarily tell you much, it could still very well be basically C.
I do it in fifteen seconds at most, stuffing it without any consideration just keeping two corners in one hand, then matching them with two cover's corners and gently shaking.

Also genuinely baffled about the article, but to be honest, not the first time that I hear someone hating the procedure and describing some problem that I don't understand.
there is also a lot of problems with pharma not wanting to invest in cures for smaller diseases because the payback seems unlikely to happen or not be great enough to warrant the risk, so this seems like a pretty good vote getting maneuver that might have unintended consequences.
Their press release ends with “As of today, this incident has not had a material impact on AT&T’s operations”. I assume that's some dumb legal requirement related to being a publicly traded company. But it sure looks like a statement of the legal problem right now with privacy breaches in the US.
It's not hard because of cognitive ability required.

It's hard because it's expensive fluff bs for jobs that have it as requirement. Useless without a position where you can exploit having MBA diploma.

There's a case in Poland that one "university" was giving MBAs like candies to party officers so they can have some higher education to occupy well paid leadership positions in publicly owned companies.

Nobody said MBAs buying Palantir or whatever came from "top" MBA programs. In Poland they would come from this "university".
Distro build hosts and distro package maintainers might not be a bad guess. Depends on whether getting this shipped was the final goal. It might have been just the beginning, part of some bootstrapping.
I'm not writing off Gazan journalism. I am making a narrow point about the lack of equivalence between journalistic institutions in Hamas-controlled Gaza and in Israel.

Aside from that: Israel is not, in reality, a theocracy (it has theocratic forces in the same way the US and parts of Europe do). Nor is Israel is not "bankrolled by a foreign power"; it would be the preeminent military power in the region were foreign aid completely cut from it.
It's not a moot point at all actually, it's the only way you protect yourself from threat actors with more control than you have: https://arstechnica.com/tech-policy/2023/12/apple-admits-to-...
This aptly describes why I keep playing exponential growth games on my phone.
Xz/liblzma: Bash-stage Obfuscation Explained
You'd probably be interested in their set of slides on techniques for constructing robust software [1]. It talks about this issue, among others. For one thing, the processors could easily be in different states due to resources each has access to, so the same code could behave differently on different processors. Another topic they touch on in the slides is the notion of having multiple implementations of the same program, with compatible inputs and outputs but different implementations written by different teams that did not communicate.

[1] https://www.fastonline.it/sites/default/files/2019-06/Robust...
(I couldn't find a version on the stratus website any more, but this appears to be the same as the one I downloaded from their site many years ago).
There's no free market for lifesaving drugs. Just extortion.
I’m just saying if you treat the cell phone like a landline it can work just as well (or badly). Hell, physically attach it to the base with a cord or something.

My rural grandmother happens to have a landline and it doesn’t work like 20% of the time because she didn’t hang it up properly.
Landlines (at least the old school ones that ran the line all the way back to a big central office, before neighborhood multiplexing devices were so ubiquitous) relied on very centralized infrastructure that was easier to keep running in a disaster, you only needed to keep one building powered to keep the town's landlines up. Sure, long distance service may have gone down when the lines outside the area were disrupted, but you'd still be able to call the fire department or your mom across town. And since that one building was so important, they kept a big generator there with lots of fuel.

The cellular network is much more disperse which makes it resilient in some ways (since if the tower closest to you goes down, you can still probably get signal from another tower), but it's harder to keep them all running, and in many cases they rely on long-distance data lines out of the area to stay in service, so even if the cell tower is up and running, without that long distance data connection, you can't make a call.
I've been doing it this way for years. Saw a YouTube video on it. Before that, I struggled to get the duvet back in the cover
No that many. It supports the most important ones though, and it is the fastest
I'd be surprised if the attacker didn't meet the criteria for mens rea.
So why is older insulin more expensive in the US than elsewhere, by a large margin?

https://www.visualcapitalist.com/cost-of-insulin-by-country/

https://www.rand.org/pubs/research_reports/RRA788-2.html

https://worldpopulationreview.com/country-rankings/cost-of-i...
I think that's difficult to implement. There's a risk that companies might end up not launching new products on the US market

There's several factors that impact US drug prices. For instance FDA approvals are significantly more costly than EMA ones and the bargaining power of healthcare providers is worse compared to a single payer system

I have no knowledge of US laws, but I wouldn't be surprised if there's some kind of law preventing government interference with "the free market"
You can throw CEO in jail and anyone responsible.
Doesn’t the price of a drug come down only once the patent expires and other drug companies can start making it?

But the reason they have patents that last like 20 years is to allow them to recover the costs of R&D.
Yep, exactly. Apologies, my previous comment was semi-sarcastic but in retrospect that was way too vague :)

On average, HN leans anti-MySQL, with concerns about Oracle ownership frequently cited in these discussions (mixed in with some historic distrust of MySQL problems that were solved long ago). But I rarely see the same sentiment being expressed about Citus, despite some obvious similarities to their ownership situation.

Personally I don't necessarily think the ownership is a huge problem/risk in either case, but I can understand why others feel differently.
Only one company is allowed to offer it as a service.
Who educates these scientists through PhD programs? Oh, OK. So we are paying these people to get their PhDs so they can go and start a company to scalp people with drugs that deliver 10% lift in efficacy. What a scam model.
I feel like this narrative is especially untrue for things like lzma where the only dependencies are memory and CPU, and written in a stable language like C. I've had similar experiences porting code for things like image formats, audio codecs, etc. where the interface is basically "decode this buffer into another buffer using math". In most cases you can plop that kind of library right in without any maintenance at all, it might be decades old, and it works. The type of maintenance I would expect for that would be around security holes. Once I patched an old library like that to handle the fact that the register keyword was deprecated.
I agree that it was vastly overblown in importance and was mostly the usual token "somebody must do something" thing with no practical meaning.

But I also think that repeatedly ranting about it now, when the transition has largely already happened, is equally a waste of time. Me, I just use "main" going forward for the reasons I listed above.
Haha amazing, I’ve now just discovered that some places don’t use duvets. I thought (naively) that it was worldwide…
So this boils down simply to cost based pricing versus value based pricing.

Novo Nordisk is applying a pricing strategy that reflects demand and what people are willing to pay.

https://en.wikipedia.org/wiki/Value-based_pricing

There are many, many MANY people in this world will to pay for this on the basis of value. Heck if I had a lazy $5,000 I'd buy 5 months worth of the stuff and I'd be extremely happy with my purchase and I would not care what it cost to make.

Losing 20 kilos is easily worth $5K to me.

The only problem is I can't get it at any price - Wegovy is simply not available here in Australia and for all I know it might take 10 years until they can make enough to supply the market.

If someone could get it for me I would pay them except I'd never trust the black market - you're unlikely to be getting the real thing.
A later submission managed to avoid getting pummeled into oblivion with flags if you're looking for discussion: https://news.ycombinator.com/item?id=39872242
> Things like insulin are long paid off, and the pricing there has generated controversy. People have been charged $1000 a month for it [1].

Humalog and NovoLog both have expired patents. There are newer, better insulins. But these drugs were state of the art just 25 years ago.
If you really think not taking product news at face value is conspiratorial, you’re far too trusting. The transactions I’m theorizing here are very common and not illegal.

“Surprisingly desperate” seems to not be coming across as I intended, I meant only that it’s surprising that a product that should sell itself is instead searching for use cases, as weakly evidenced by this article but more strongly evidenced by their many past pivots without significant adoption.
See also complaining about downvotes.
There is currently a supply problem. Novo Nordisk is building more capacity, but it takes time. Meantime those who are willing to pay more for it, get it. Mostly citizens of rich countries.

Novo Nordisk is controlled by the Novo Nordisk Foundation (> 77.1% of votes, 28.1% of capital) with aim to make a positive impact on health, science, and society by generating long-term returns on the assets of the Novo Nordisk Foundation.

One of the reasons why Novo Nordisk has been so successful is because their owner takes a long term view in R&D unlike purely profit-seeking owner.
According to Acquired.fm, they are required to sell their products at cost in Denmark, and allowed to make up for that around the world. I am curious for feedback here on the accuracy of this information.

I can't believe that I'm sharing YouTube shorts on HN, but this is the best way to share this info at the moment:

https://www.youtube.com/shorts/IVut-PE6LCA

https://www.youtube.com/watch?v=lsCvQSNsaVk
You can have a much higher quality material for both inside and outside, and washing the cover is easier than a full comforter. You wash the inside more rarely with a duvet cover. You can also have one inside and many covers for variety of styles during seasons without having an entire room of the house for storing comforters
Most of the people I knew in Australia 10 years ago had duvets. I never even knew what a duvet was until I went to Australia. Moved back to the US and got one. I can only think of one other person I know here who has a duvet
Any details? Could be adjacent self-hosting issues compared to headscale itself.

Considering it can also run in a docker container, it’s next to trivial to install locally to try out

https://headscale.net/running-headscale-container/
One of the most interesting examples is Mitchell Hashimoto of HashiCorp fame (13B publicly traded company). His career path was: HashiCorp CoFounder -> CEO -> CTO -> Engineer -> finally left HashiCorp in December 2023.

Now he enjoys private life while creating a super-cool Ghostty terminal in Zig [0], currently in private beta.

[0] https://mitchellh.com/
kens is the author of the write up, not the designer of the chip.
I am wondering if reinstalling the entire Archlinux installation would be a wise choice.
I'm using it for an exams booking company https://www.mtsglobal.uk.com/
It powers the calendars used both on the public side and the admin side, as well as a few forms and admin context switching. (solo dev)
As a primarily backend dev, it was easy to get around, and allowed me to get things up and running much quicker.
Didn't solve everything, some selectboxes that updated each other wasn't a great candidate, so JSON was used here (Choices.js) as reinitializig the select box was a bad idea.
It is a puzzling omission.
Rxdb looks neat. I’ll def take a look. Thanks for sharing
The older products are much more expensive in the US too. It’s price gouging, and that’s when regulation has been imposed.

The newer products are cheaper elsewhere in the world. The US is getting ripped off by big pharma.
Also known as the “burrito roll”
The criminal conspiracy laws don’t apply to the organizations that write this kind of code, just like murder laws don’t.
Ah yes another company she can run into the ground. Her track record is horrible. Remember when Yahoo leaked like a billion users info under her command and the company attempted to cover it up?

Keep failing upwards Marissa.
Quarto on Hugging Face
> I am making a narrow point about the lack of equivalence between journalistic institutions in Hamas-controlled Gaza and in Israel.

I am arguing that the distinction doesn't matter when both sides field individuals that behave with equal vitriol. Hamas-controlled Gaza is a neverending humanitarian trainwreck, comparing the strength of it's legitimized institutions to the country pillaging it is a farce. I'll admit that you're right about a lack of Hamas Times newspaper, if that's what you need to be happy.

> it has theocratic forces in the same way the US and parts of Europe do

Does it field serious non-theocratic armed forces? There are none that I'm aware of, but maybe Google is hiding something from me.
On the other hand, if you believe some venture is scam, or is actually rotting under a glossy exterior, then it makes sense to keep writing about it and attempt to expose the situation over time. Especially if the subject keeps trying to cover up and advance the false narrative.

So here we are today, who was right in the end?
>better sock puppet accounts though.

Seems like to me they had perfectly good enough sock puppet accounts. It wasn't at all obvious they were sock puppets until someone detected the expliot.
Pharma stocks actually underperform compare to other companies. So, it's not like pharma companies are making insane profits. Research, regulation, approvals and failures are expensive
The Spanish sticker rebellion battling tourist lets
That's a likelihood it would seem.
This could've happened to anybody, frankly. The attacker was advanced and persistent. I cannot help but feel sympathetic for the original maintainer here.
Only the last one makes the distinction between modern synthetics and basic insulin.

Frankly the US pays for the cost of the research while the rest of the world just pays for the cost of production.

If you want to fix the cost of insulin products (and many other drugs) in the US you need to figure out how to make everybody else pay for the true costs.

Edit: also your last source there doesn't even know what it's talking about Novolin is a generic brand name for 3 distinct products that have distinct pricing.
Is it ethical for a doctor to accept payment for life-saving services, then?

A much more interesting discussion could be had around who pays for it (and how, and how the prices come to be as high etc.) – because somebody ultimately does.
Can someone with more knowledge chime in here? From my western POV the step from "veg only delivery crew" to "caste based delivery crew" seems huge. The article makes it out like it's the logical next step. Seems a bit odd to me.
> Something so valuable it's worth dedicating ~3 years of your life to it?

This isn't the right mindset if you want to consider a state actor, particularly for something like contributing to an open source project. It's not like you had to physically live your cover life while trying infiltrate a company or something.

Yes, this is a lot of resources to spend, but at the same, even dedicating one whole FTE 3 years isn't that much resources. It's just salary at that point.
I wrote about this issue back in 2018 regarding specifically Chrome, and Firefox's settings are derivative of Chrome's: https://danshumway.com/blog/chrome-autoplay/

At the time, there was a lot of noise about the fact that autoplay settings were breaking parts of the web, and I do think that was a problem with Chrome's setup that never really got addressed. My article focused only on Chrome's changes.

Firefox's approach was (imo) better -- it didn't have as much of the weird AI-driven "figure out which domains users interact with" nonsense -- but Firefox's approach was still very clearly influenced by Chrome's, and I would argue that Chrome's approach was incorrect.

At the time, there were two concerns, and Chrome's approach was only intended to handle one of them:

1. Autoplay videos use a lot of bandwidth

2. Autoplay videos are disruptive (specifically, they make noise)

Chrome was worried about #2. They argued (and I agree with this) that these are two separate concerns that need to be tackled separately. But Chrome didn't really go all-in on solving problem #2, they kind of had this weird hybrid approach where they were still trying to stop the data from being streamed, but not always, and if you muted the video it would still be streamed, but if you didn't it wouldn't...

So it became the worst of both worlds.

At the time I argued (and I still think this would be a better approach) that given that the goal was entirely about stopping audio, this should have all been handled through automatic tab muting, not through a change to the web APIs.

That's not to say that blocking large amounts of data or stopping the visual aspects of videos isn't important, but the approach Chrome went with (and that Firefox has subsequently inherited) kind of does nothing well. And I think we still see the effects of that today, even in browsers like Firefox that were admittedly a bit more sensible about not adapting some of Chrome's worst ideas.

Interactions were also a sticking point: Chrome interpreted even highlighting text as a signal that autoplay should be allowed -- which is obviously very easily abusable. I generally think that the user-gesture requirement for permissions is not great; it severely limits what users can do on a page while still signaling that they don't want to grant permission for a random action like autoplaying audio.

It's a tricky problem to solve, but I also think it's a problem that's harder to solve because of some of the previous baggage we've inherited from previous efforts to solve it.
I love my Clara HD. And it's jacket pocket sized. It easily fits in the chest pocket of a winter jacket or the side pocket of a puffer jacket.
I'm not sure there is other model, unless we move to entirely funding drug research publicly. And then set some bidding process for manufacturing...
That sounds noble but... What do you propose? Free drugs for everyone? If nobody is allowed to profit on researching drugs, nobody has a reason to sponsor drug development - which is very expensive.

Of course I agree this market should be regulated - like we regulate it in Europe - but at the end some company is investing into drug research in order to make a profit.
Some people will cleverly glue a leaf over 50, 60 or even 80% of the number. How did it get there? I don't know. Must be nature's fault. I'm so sorry officer.
Are the people running drug companies barely scraping by?