skysight-inc/HackerNews huggingface dataset:
I have CF, and I take Trikafta.
Before Trikafta, I usually had a 5+ day stay in the hospital every year, and sometimes I have would very stubborn respiratory infections that just wouldn't go away. I was mentally preparing myself for inevitable decline and eventual death.

Trikafta changed my situation dramatically. I've had no hospitalizations, and most the classic CF symptoms are either gone or extremely diminished. It can't undo a life of damage to things like my pancreas, vas deferens, etc, and I still take medicine to digest my food, but overall, it's as close to "normal" as I could hope for at this point.

The only real downside: weight gain. With CF the pancreas is blocked, so you lack in digestive enzymes, and it's a struggle to maintain a healthy enough weight to battle respiratory infections. After Trikafta, I gained some 30 pounds, and have a big belly on my small frame, and went up some 6 inches in the waist. To add insult to injury, it happened during the spring and summer of 2020, when buying clothes was a challenge due to the pandemic.

Speaking of the pandemic, the timing of Trikafta was amazing: it kept the normally full "CF floors" of hospitals empty, opening up those beds for those with COVID and keeping CF patients less exposed.

One side effect I should mention: many report extreme anxiety. However, I was starting an anxiety medication for the first time (something I should have done 20 years ago, but alas ...) and so those effects were muted or hidden to me.

(copied from the last time Trikafta was mentioned here: https://news.ycombinator.com/item?id=37540731)
People is not offensive and neither is folks. No offense but what bizarro world are you all living in?
> I'd look at this from a different perspective. Why does one hire a janitor? Is it because you're incapable of cleaning a bathroom, mopping, or sweeping? No, it's because you have different priorities for your own time.

I'm not sure if you are talking about a company or a person or what kind of entity really here.

I'll assume a private person.

So you think people who clean bathrooms do it because they don't have "different priorities for their time"?

That sounds backwards to me.

Edit: and it is, of course, logically.

What I mean is: to have different priorities for your time, you either need to be able to earn more money in the same time, or not need to earn money.

That brings to mind for me another fact: much of art, literature, philosophy, science and other things that we historically have built on was done by people who could afford other priorities in their life than cleaning their bathroom, preparing food, earning money to obtain food...

Of course this will stir up the question of meritocracy and how capitalistic society really functions for some.

But the way you put this question seems naive to me.

I don't think that most people who clean bathrooms for a living do that because they set this priority for their (life-)time.

That doesn't preclude being a janitor from being a potentially satisfying and certainly valuable job.

I know I'm mixing up the terms janitor and cleaning bathrooms here, but I felt that it was already unclear from your comment what kind of job you are talking about. Might be the language barrier.

A janitor hase more responsibility of course than just cleaning bathrooms.
To be specific (as best I can; this conversation was about five years ago now), the radios used a form of symmetric encryption. The company would have squads of under ten soldiers, working covertly behind enemy lines in sabotage and reconnaissance. I don't remember whether the radios could communicate with each other only within the squads or across their entire platoon, but the thing that stood out to me was this: should a single soldier be captured (they'd be in enemy territory after all), each other soldier would have to meet together in person to reset the encryption keys.

It's hard to believe, but if I understood the chap at the military exhibition correctly, the enemy could use a captured device to listen in to every communication among the squad/platoon, which would presumably make it perilous for them to reconvene again in secret - precisely what they would need to do in order to cycle the keys.

If a more PKI-style mode of encryption was used instead, there could be a 'dead-man switch' or emergency button on the radio that would send a revocation certificate to all the other soldiers' radios if one was captured, causing the platoon to immediately cease encrypting their signals for the compromised set.
I'm being facetious in speculating how it would be a "psyop."
> The Phase III trial has just read out, and Relyvrio shows no hint of actually working.... It did have a very good safety profile, fortunately, so it seems unlikely that anyone was physically harmed.

Phase II trials are more about safety than efficacy, so I'd say the system worked as designed.
Humans can’t even align with human needs.
There was no way big enterprises were going to allow those ‘toy’ iPhones on their network.

That was the attitude for a minute until the CEO got a cool iPhone.

Same with Macs. And jeans.
Not only that but the heart rate changes with your breathing, physical activity, thoughts, emotions ... I want to say it "has the pulse" but that sounds like a corny literal use of the expression.
The gap between the Pro is increasing over generations. M2 to M3 Air isn't as significant as it should be.
Germany: The Fight Against Tesla Gigafactory: Occupy Forest/Shut Down Power Grid
This is a big story, and it seems curious why it isn't on the front page of HN.

Also weird are the comments alleging this is really some US spy op, and not the Russian state.

Russia has the motive and means and unless other evidence comes to light, it seems likely that they are behind it.
Sure, but I'm not sure what your intent is for bringing this up.

If your intent is to claim that this is evidence bigcorps aren't still fighting against piracy, I don't think that's true. Corporations are amoral, and it's naive to expect that they have a consistent ethical stance which they apply to themselves.

That is to say, Microsoft can be pirating everything they can get their hands on while at the same time trying to prevent anyone from pirating their intellectual property. They don't care that that's hypocritical; it's profitable and that's what matters to corporations.
That’s explained at the end of the post: in the real code, that’s the most efficient place to calculate it, and it was passed back out as well.
Not a huge fan of vim, but showing line numbers is one of the first thing I do whenever I rarely edit a file, but I never recall the command. Why didn't they put it in the graph ?
We'd like to make money off Hatchet Cloud, which is in early access - some more on that here [1] and here [2]. Pricing will be transparent once we're open access.

Like I mention in that comment, we'd like to keep our repository 100% MIT licensed. I realize this is unpopular among open source startups - and I'm sure there are good reasons for that. We've considered these reasons and still landed on the MIT license.

[1] https://news.ycombinator.com/item?id=39647101

[2] https://news.ycombinator.com/item?id=39646788
Terrestrial life is young relative to the Earth.

The Earth is 4.5 billion years old. The forest described here is between 358 and 419 million years old, or rather less than one-tenth of Earth's total age.

Australian and Canadian shield formations date back as far as 4.4 billion years. That far exceeds any dry-land life, let alone fully-developed forests.

<https://opengeology.org/historicalgeology/case-studies/earth...>

At best you might find stromatolite beds, remnants of ancient cyanobacteria growing in mats in shallow seas:

<https://en.wikipedia.org/wiki/Stromatolite>

The formations in which the UK fossils are found were at the time of their formation linked with the ancient Appalachian range, parts of which remain now in north Africa, the eastern US, Spain, France, Britain, Germany, Poland, and Czechia. The Appalachians themselves are older than terrestrial life, which is to say, older than dirt (which is itself comprised of organic matter). There's a river which flows through the Appalachians which is older than the mountains themselves. It is of course named the New River:

<https://eos.org/features/the-new-river-gorge-ancient-river-o...>
Disney sends me someone else's tax forms and information every year to my Gmail address.

There's a couple spreadsheets on their royalties for songs and their streaming revenue broken out by region, then by provider. It's for multiple items that get a couple million listens a year, one song has 7 million in one month in the UK, of which "she" sees 50% revenue. Totally payout for the 7 million month? 54 cents USD.

These are songs for a mid 00s - early 10s animated TV series.
It may also not be wrong to say: "those who know history, are destined to repeat it".

"That which is the common to the greatest number gets the least amount of care..." is not a universal law, and it is easy to think of counterexamples. Without listing these, here are some axes that can govern which side of well-cared-for resources in the commons may end up:

- the extent to which people hold cooperation to be an important ingredient, versus dispensable
- the extent to which people are able to trust others, versus not
- the extent to which a commonly held resource is considered as much a personal resource, as a common one, versus purely common and otherwise inconsequential
- the extent to which people are able to value the importance (and impact) of small, consistent actions versus grand(iose) ones
- the extent to which people are willing to learn from mistakes and change, versus the extent to which people feel entrenched and defensive

Most of these come down to education, culture, and type of previous interactions with other humans.
I assume that french word must translate to "federal government" in english, right? What you've written makes no sense otherwise.
I grew up with Asus and Acer and then Dells and Alienwares and Surface Books and ThinkPads and Razers, comfortably in the Wintel world. But the Apple Silicon laptops are so far ahead it's not even a comparison. Especially if you want to be able to run Photoshop natively (ie not emulated in Linux).

Forget the metal dings. The new ones have smoother edges, I think. Run an automatic backup to somewhere else.

The hardware is so so so much better than anything else out there there's not really a comparison. I doubt anyone else would catch up within 5 years either.

At the end of the day they're just tools, not some religious argument. At this point in time they're substantially better than anything else, by a large margin, especially for dev and creative work.

I also use IntelliJ and Photoshop side by side, and these crazy machines last the whole day on battery power without the fans ever kicking on or anything getting slow. The poor throttled Thinkpad X1 isn't even remotely close in performance.

Shrug. Sorry, probably not the answer you wanted to hear. But Apple did some serious engineering in those while Microsoft and Intel sat on their butts for a decade.
Any suggestions for under $1000 (excluding tax)?

I've looked at Thinkpads and all the good ones are well over that price.

My priority is light weight and at least a 16GB/512GB combination. The only laptop I could find that meets this, based on suggestions in other comments, is the LG Gram.
I'm strongly in favor of experimental drug trials, most of which will fail. "False hope" is a small price to pay.

According to the article, the evidence for this drug was never substantial. We know it doesn't work now, onto the next.
I believe you'd use it with RAG. It would ensure the model properly sites the text you feed into it.
Dune jokes about the Golden Path.

Without much spoilers a super powerful thing set the universe into one direction where he's the emperor and everybody else suffer at his will because according to him all the other possibilities were even worse.
Who is paying for these drugs that have insufficient evidence of efficacy?
>But I'm still not convinced that it would result in more jobs. If you saved money by automating away labor, why spend the savings on labor?

The proponents argue the savings would be spent on laborers doing other (possibly new) jobs that are not yet automated and hired by different companies.

EDIT reply to: >I can't see what new jobs would be created, especially high value ones.

Yes, I agree about not being able to see new jobs. However, history has shown we (society) have always failed to imagine what the new jobs would be that takes the place of old jobs automated away.

Farmers and field workers replaced by tractors and harvesting combines. Human telephone switchboard operators replaced by automatic digital relay circuits. Travel agents replaced by website airline ticket bookings. [Thousands of other examples...] And yet the total # of people employed still keep going up instead of society dealing with massive 95% unemployment.

The paradox happens because the farmers and switchboard operators that were disrupted can't possibly envision new types of jobs that exist in the future. Understandably, the displaced farmer can't imagine there would be a job where somebody ... presses keys all day on a "typewriter like mechanism" that sends instructions to an "interactive tv". That basically describes what today's programmer does at his computer the entire day.

So, the new AI could usher a new wave of jobs. (Something more unpredictable than the immediate memes of ChatGPT "prompt engineers").

As we're living in the moment, we're also "blind to the future possibilities" like those farmers. If one could go back in time and tell that farmer in 1920s driving a Model T that there would be new and different jobs replacing farm work, you wouldn't be able to convince him. In the world that he's familiar with, our attempted descriptions would all just be speculative science fiction. Likewise for those of us today that's pessimistic about AI affecting jobs, is there really anything anyone could say that would change our minds? It's just predictions that we'd just dismiss.

The counterpoint to AI optimism is that _this_ new type of automation with powerful AI is unlike the tractors/microchips/websites in the past that replaced people and much more disruptive.
> EC2 instances can be rebooted at any time

No, they can't be rebooted any time. Where are you getting this information from?
Interesting note about Trikafta and other advancements in cystic fibrosis: the Make a Wish Foundation announced that children with CF now no longer automatically qualify for their program due to the advancements in care.

https://wish.org/cf-update
https://www.youtube.com/watch?v=fURATK5Yt30&t=173s
So why do teeth experts have the final say on whether we put heavy metal, nuclear waste products in our tap water?

Perhaps the concern isn't the 2% dental improvement, maybe that's just a red herring. Perhaps an actual toxicological study would be more appropriate.

I know that some water sources have naturally occurring fluoride, which is often used as an excuse or ad hoc justification for it's efficacy, but that's just fuzzy, wishful thinking.

Also the fluoride they put in the water is not derived naturally, but instead is largely the result of nuclear waste byproducts that, if they didn't put in the water, they'd have to pay to dispose of safety, so let's not forget the massive conflict of interest in studies like this to find any excuse to keep up the status quo.

The act of avoiding the cost of safe and responsible cleanup by simply injecting a small amount of poison into the food or water supply is fairly common practice, and if regulatory agencies had any actual interest in public or environmental health, that'd likely be one of the first things to legislate on.

So yeah, nice try, but no thanks.
Updates to Cystic Fibrosis Conditions Qualifying for a Wish
I am still searching for reasonably priced T-Shirts that only have seams from the armpits to the hips (one such seam per side), and optionally at the 4 holes for edge reinforcement.
Critically, this means no seams on top of shoulders by any reasonable definition of what "on top of shoulder" means.

You could knit it on a tube knitting machine capable of adjusting loop count/circumference freely.

But for a T-Shirt you have very fine knitting, so regular knitting machines can at best do newborn-sized T-Shirts.

If anyone happens to know where I could order a dozen shirts knitted to spec based on knit design rules and published-by-them loop-pitch-after-first-wash from cotton, I'd love to hear.
Python is a common example. You can use a debugger in vscode but I rarely see people do this, opting instead for print statements everywhere. But for javascript, the ability to put breakpoints into sourcemaps is invaluable, because trying to debug minified or transpiled javascript is a pain in the ass, and yet I still see people console.log everything
For anyone who is willing to use a webapp, I like drawio[0]. You can download locally[1] and self host (I just use the python webserver).

While finding the Github, I see they now actually package an Electron application, so that is probably worth exploring[2].

[0] https://www.drawio.com/

[1] https://github.com/jgraph/drawio

[2] https://github.com/jgraph/drawio-desktop
the harm is not all drugs are safe - even if this one was (and we aren't 100% sure of that either), and pharma companies using social media and/or sympathy stories to pressure regulators into approving a drug that would not otherwise get approved is gross.
> Interesting they chose 3 more left leaning board members. Surprising an AI-focused company wouldn't have more diversity of perspective at the governance level.

Are you suggesting that diversity of perspective must come from people of different genders? That's weird.
Could you explain more what you mean by this?

I guess there’s the fact it made it to Phase III before they canned it meaning more people were hopeful than if action were taken to stop progress sooner.

But, how can progress be made if failure is disallowed because of unknowingly giving people false hope?
> But it wasn't the case that thousands maybe millions of people could be compromised (or spied on by governments) in one go.

And? Besides you being hysterical. What happens?

> The trend towards online everything, is equivalent to putting all your eggs in one (huge) basket.

And? What happens if the internet disappears today? Life goes on.

> but if it is the case that there are no alternative viable options but to accept a compromised state of privacy

For most of humanity, people lived without any right to privacy. You want old-fashioned right?

> I absolutely get why governments and corporations are fine with eroding personal privacy for their benefit.

Governments and corporations are run by people too.

> that there is eventually some consideration given to privacy and its loss.

There is more consideration for privacy today, especially in the online world, than in the real old-fashoined world.

How about you set the example and go offline for a bit? Get some air.
Also the rolling hash is only on map keys, so replacing fixed-size values requires no splits.
Germany: In the Streets Against Fascism, Again
What happens to an aluminum block when 0.5 ounce of plastic hits it in space (2019)
What happens to your brain when you become a billionaire (2022)
Thanks for sharing. What do you use it for mostly?
not to mention the revolving door between drug company execs and regulators - which is ripe for conflicts of interest.
That's a lot of effort. I hope Square Enix doesn't give them a problem.
Biden backs effort to force sale of TikTok by Chinese owners
While the current participants in the system might not be perfect, it should be appreciated that humanity has seldom had it better in terms of being able to trust civic institutions.

I don’t see the purpose of complaining about it in a situation where the institutions are working as intended (and desired).
Aren't those keyboards usually readily switchable with a standard US keyboard layout (e.g., in Windows, MacOS, or Linux)?

Do you have any direct experience with this?

My point is that 7-bit ASCII underlies virtually all other keyboard / character encodings. Among the few cases where it doesn't (e.g., IBM mainframe EBCDIC, independent of ASCII), the principle encoding remains the Latin alphabet, and can readily be converted using standard system utilities.
That's pretty inefficient if someone wants to avoid buying any of the products affected by the case.
So it could be “Computing With Processors”. That could be the title too. Having said that, I think this is a terrific title.
I suppose we can try no new drugs and give nobody any false hope, presumably we'll be better off then?
FDA Designates MM120 (LSD) Breakthrough Therapy for Generalized Anxiety Disorder
Could be. After 40+ years of thinking I learn better from books I changed my mind after seeing one of Freya Holmer's videos.

I can definitely learn faster from a video as long as there are no talk heads in it, and only content.

Trouble is, all the instructional videos I had tried up to that point were crap. I can't think of even one highly recommended programming instruction video that is any good for me.
Taliban fosters YouTubers to promote its image
A Relatively Important Question from a Reader
i totally agree. the drugs are a huge health problem, but also psychological. Having to care for the elderly I've noticed the drugs serve another more concerning purpose. They create a psychological dependency from the patient onto the doctor / healthcare provider. The patients treat the doctors like magicians because of their control over meds.

Breaking drugs out to pharmacies, Mexican style, would go a long way to interrupt this dependency.
How to Be More Impressive
> Now, listen. I wish I could continue here and end with “… and this is why ZSH does it that way!”

https://github.com/zsh-users/zsh/blob/47c7bc9b1493c7374f076b... has a comment about this behaviour, but no justification. I think it's just an optimization to save a little bit of time by not forking, and to avoid having the zsh process hanging around taking resources for no reason.
You should write it down. I had such a password that only my fingers knew, not my head. Then I went a couple of months without using it. When I wanted to type the password again, I had completely forgotten it. Without even knowing the first letter, I had no hope of guessing it.
Indeed it is, but maybe they should call it STM3264 :D
Easy for users, one step backup and restore of system-wide state.

Less easy for developers, but code is mature and stable in production for years.
There was a good article on this in the New Yorker a while back:
https://www.newyorker.com/magazine/2023/06/26/relyvrio-als-f...

It's sad that the drug didn't work (and I had a cousin recently die of ALS), but it's important to let the FDA do their work.
Small FPV quadcopters are terrifying in war.

If you haven't seen it yet, go checkout whats on r/CombatFootage, its essentially killbots that follow soldiers around and explode on contact or drop grenades. I think this is a future of warfare which we are not talking about enough. If the Ukraine is able to make these effectively with consumer technology, unfortunately everyone can, including criminals looking to make hits.

I could see this fall out in a few ways:

- Operating personal drones and other small craft will (and should) become restrictive, if not outright prohibited outside of designated areas. All commercial drones outside of these areas will have to have squawk their position and registration.

- Eventually radio jammers will not be effective countermeasures against these weapons. Machine vision, and a simple AI which could be crammed into a SoM (e.g. IoT AI products), lock onto targets and follow them into areas with radio jammers.

- Anyone who needs security protection will probably be spending a lot more time indoors including events.