skysight-inc/HackerNews huggingface dataset:
This is about as succinct a summary as it gets re mRNA's potential:

"To create an mRNA cancer vaccine, a patient’s tumor is biopsied to identify unique target mutations —> mRNA correlating to mutations is synthesized and injected into the patient —> the patient’s cells create the targeted protein —> the creation of foreign proteins stimulates the immune system and teaches it how to recognize the target protein —> The immune system (especially T cells) search for this target protein and destroy the cancer cells to which it’s attached."
To save topsoil and reduce pollution, Bangladesh moves toward alternative bricks
> i bef'ed the Makefile, removed a character, tried to 'deconstruct' it, the output is zero bytes

I can't reproduce this. These are the commands I used, with it freshly compiled on a ubuntu docker container, both the v0.1 release and the master tree.

./bef -c -i Makefile -o Makefile.bef

dd if=/dev/zero of=Makefile.bef bs=1 oseek=300 count=1

./bef -d -i Makefile.bef -o Makefile2

cmp Makefile Makefile2 || echo "failed!"

edit: oh, I see, you 'removed a character'. Depending on what character you removed or corrupted from the output, you could've either hit the issue described above with inserting noise, but this time removing information, or you caused corruption in the header by either corrupting the magic number, hash type, or hash itself. The command line utility automatically truncates the output before calling the deconstruct function. The header is sadly the biggest single point of failure in the tool/format, which is why I introduced the --raw flag for those who don't want it.
Have you written about your experience or contacted any researchers? I'd assume some scientist somewhere would love to know more.
If I understand correctly, here it is transparent. In an eager language a function needs to know whether it is given a value or a thunk, but here it can be both interchangeably (the thunk only need to have a type that says it returns a value of the same type as what could have been passed directly).
This is a very sloppy comment. How do you know that about 'the new board', exactly? Are you already an expert on these 3 women and know their background and all possible connections to Altman? I doubt it. (I'm not.) They could be an Altman plurality already for all you or I know. And which 'new board' not having an Altman plurality are we talking about, exactly? You're not seeing 'the new board' - you're seeing the announcement of some expansion. The 3 women & Altman are not the entirety of the new board. (For example, Brockman seems likely to be reinstated in the followup appointments. I'm also curious if the MS observer is still going to be there.)
It's important to understand this, but it's very easy to work around this problem. Give the language model the information you want make the decision off of, and not the information you don't want it to make the decision off of. Strip the name and associate an ID that the model can use to associate it's answer with. This can be pipelined to automatically replace names and then reinsert them after, so the person using the system doesn't have to track IDs manually.
Would it make sense to use a Prolly Tree’s root hash as the ETag for a collection resource in an HTTP API?

Given an HTTP API that:
- includes a collection resource to which items maybe added and removed
- and for which supporting an ETag response that reflects the current set of items is needed
- where it is prohibitively expensive to enumerate all items to recalculate the ETag

It seems an incrementally maintained Prolly Tree would be an efficient mechanism and the root hash could be used as the ETag since the order of operations isn’t important. Do I have that right?
Making the immune system target tissue produced by the body, even a cancerous growth, is risky business.
Everyone keeps nattering on about AI, but this is the big story.
Without looking at the code, I can tell you that this will reproduce one of two things:

1. Invoke function that has two side effects

2. Function does first side effect

3. Pull the computer's plug out of the wall

A framework can only do one of two things:

A. Invoke the function again

B. Not invoke the function again

If you choose A, you have at least once processing

If you choose B, you have at most once processing

Neither of these are exactly once, therefore, neither one of these are idempotent unless the first side effect that the function performs is also idempotent. That is, you must be able to retry that one.

I believe you mention exactly once processing in another comment. It's this. The massive lie that many of these types of frameworks tell is that they can manage idempotence for you. Aside from functions that are side effect free (that is, pure, that is referentially transparent, that is can be made mathematically idempotent) you cannot possibly make them idempotent. It's the two generals problem.

So, I believe what you have implemented is idempotence at the sender with the reservation pattern. This is not the same as idempotence at the processor which is literally the only thing that matters. Idempotence at the sender is simply a performance (or storage, in the case of event sourcing) optimization.

Please correct me if I'm wrong on any of this, but if I am, then clearly my understanding of the two generals problem and distributed systems are wrong and I'm going to have to do some significant rethinking of our system's architecture.
If you did that, there would be a rush of (not necessarily) terminal patients signing up and mostly dieing anyways (hopefully of their terminal illnesses)

There would be, as expected, a large contingent of patients who were poor, alone and maybe not very terminal. The very same reason which lead to the creation of ethics committes
I love scheduled send. I find it amazing iphones still do not have that extremely basic functionality.
Real-life Weekend at Bernie's? Ohio women take dead friend on a bank run
It mentions Rain Man and X-Men but misses the closer fit, Phenomenon (1996). But the word keeps cropping up, including in the subtitle.
I got some results.. scrolled a bit..
did ctrl+f -> Backlit

interesting that is goes up or down a few chunks, but does not go all the way up to the top.. if I scroll more and then redo the ctrl-f then it does find and highlight the cheaper ones that have backlit in the descriptions..

suggest adding more sliders for things like price and ram,

Also no way to know if others have a backlit keys but just not showing in the short description, that would be a nice checkbox to toggle, along with remove all that have 8gb ram - and remove all lenovo.

Also if it's amazon, then remove all that are third party sellers - I wouldn't let my parents buy a computer or battery from a third party seller on amazon or walmart or anywhere else.

random thoughts, hope they help make it better
This kind of has me wondering if this is actually good for the body. Ketosis is not without downsides. Alcohol actually acts much the same way in someone completely not used to it. Interesting to hear that it's not just me, and the people who do this all the time also suffer.

So the idea is to ignore the body's defense mechanism in order to... what? Lose weight? Feel good about having suffered through this? I guess I'm trying to figure out the upside. Like lowered social inhibition with alcohol :)
You're arguing here that leadership uses procedure to help them wield power. I agree with that.

What you said above is "the House and Senate rules are so complicated that only a few people can understand them." I disagree with that. For example, obviously the leadership and their staff can understand them, since they use them to wield power.

My argument all along is that Congressional procedure is not that complex, but most people don't bother to learn it because there is no incentive to do so. If you are in leadership, you have the incentive.

Also be clear, I think that the rules are used to wield power but are not themselves the source of much power. You don't become Speaker just by knowing the rules better than anyone else. But once you're Speaker, knowing the rules can help you do things.
You have to do a shift or two but no divides. That's the beauty of Bresenham's: You can draw the line without ever explicitly computing the slope.

In effect, Bresenham ends up performing a division by repeated subtraction. And at every subtraction step, it outputs a pixel.
First, astrobiologist is a really cool word....

DNA exactly stores experiences. thats why its DNA....

What makes you a person.
https://apnews.com/article/russia-ukraine-war-sea-drones-exp...
I’ve found myself infected with a desire to have a machine shop. I don’t exactly know what I’d use it for, but there’s something so cool about making your own stuff.

This fellow inherited his grandfather’s machine shop https://youtu.be/hearLttbrLo?si=r2CHxdepmhQ71xJq and used it to make… a pen. https://youtu.be/j27RKTHMLkA?si=f5OPN7ZJ10EBSZa4 And it’s an addiction I didn’t know I had.

The gateway drug that led to all of this was a video about a $200 CNC mill https://youtu.be/K9pjduKSsKs?si=mOJGCF9X6_s7d-J9 which led to a tour of his machine shop https://youtu.be/bHnfvtYHn7k?si=w65ZPfYm_5xpdkcD and a video about making a library. For his apartment. With a ladder that rolls along the shelves. https://youtu.be/DPRQaPVuRxU?si=uyR5xMDWgrYzHqlp

I’ve been making things for… I probably shouldn’t have calculated it, but it turns out to be 23 years now. They’ve all been digital. Somehow it never occurred to me that you can just make things yourself rather than buy it from Amazon. It sounds stupid to write it out like that, but it’s an easy thing to overlook, because you can go your whole life without thinking about it.

There’s also no limit to the stuff you can cobble together. Here’s someone whose channel averages about 30 views per video, who made a vacuum pump out of a refrigerator compressor. https://youtu.be/4Zg0EXvyD-4?si=f6oB8ScuhDd64T6n (His channel also has hundreds of videos with dozens of projects, including making his own friggin’ laser CNC machine from scratch via arduino and time. https://youtu.be/0z-zXQ2INp4?si=Y0Ao6dwr1YpQVqU7 I have no idea how no one has noticed him yet.)

All of this culminated into an intersection of everything I’ve been interested in recently: 3D resin-printed molds for plastic injection molding. https://youtu.be/wMRSPXt48CI?si=5IeQnSi89byrr0Il You can make practically anything you can think of, and they don’t feel cheap. Not to punch down on normal 3D printers; some people love them, but a larger contingent dismiss most of what they can make as cheap toys. They’re not wrong.

It’s interesting tracing a line from the Stone Age tools to these. The people back then were smart and industrious. If you gave them a lathe, I wonder what they would have made.
Do you plan on supporting SQL queries? My top 2 would be postgres and snowflake.
I only use a debugger to find where a hidden problem is.

Normally I just sprinkle lots of logging statements around, which tell what is going on and when that occurs, and building a bigger picture of what's happening in the program.

I also turn on as many warnings as possible with the compiler. Fixing those warnings as they appear prevents lots of shit later in the development process.
It’s also extremely similar to R and Rebol.

(In fact, R isn’t just ‘extremely similar’: it does use fexprs, though without mentioning the term.)
I've said above, if there aren't other treatment options available, it makes sense, but even then I don't know why one wouldn't use standard immunotherapies instead, which are less risky.

I think Moderna and Pfizer generated a lot of profit from the vaccines, and now they need a way of turning that over into capital, and they are still trying to find ways to have widespread adoption of regular mRNA treatments. But even millions or billions of dollars of capital investment will not yield a profit if its a bad investment.
Yeah, links to build instructions would be awesome
> RNA is fragile. So, like in the COVID mRNA vaccines, these instructions can be delivered in a protective fatty bubble called a “lipid nanoparticle.” Think of it like a balloon made of fatty acids, with the instructions nestled inside. Once injected, these lipid nanoparticles take the mRNA instructions into cells, where the fatty bubble degrades, mRNA instructions are released, and the cell’s machinery start to produce whatever protein the mRNA tells it to.

I still don't understand how writers about mRNA vaccines gloss over the numerous details that should be important. The picture that she paints lacks a targeting mechanism. Which cells will these lipid nanoparticles enter? She does not say. How much protein from the mRNA will those cells produce? It can't be predictable, right? Will there be significant differences in the dose of the final product between individuals? Is this important? She does not say. Will the cells that engulf those lipid nanoparticles be destined to die, in case the protein they produce is a foreign one, like the spike protein of Covid? They must be, right? After all, that's how immunity works. Is this important, given that there is no targeting mechanism? She does not say. And so on...

What makes an mRNA vaccine more appealing than a protein-based one?
> But you weren’t talking about pot.

I was. I was replying to a comment that was talking about pot; and the comment I was replying to was on an article that was about pot. In context, I would have thought "medicate" would be understood as "medicate [with cannabis]".

> You were talking about people treating their work related depression and stress being a bad thing because it enables their employer to depress and stress them. At least, that was the message I got.

Nope, nope, nope. You brought up antidepressants - as I said before, I think that's an apples-to-oranges comparison. Recall the original comment I was replying to in the first place - it talks about being "more eager to work and more resistant to burn out" via pot and people "continuously stressing out and thinking about changing jobs". And I don't think it remotely bad to treat depression or stress with medication, at all.

Now maybe somebody is about to burn out and thinks about changing jobs because they're depressed, but that's reading a lot into it. My comment was trying to talk about leaving toxic and shitty jobs. You're bringing a framing into it that I do not agree with and didn't ever say.
> You can build gates, which is nice for switching packets, but how do you store data?

Logic gates can be the fundamental building block. So if you can build logic gates, then you can use those to build flip flops (the basis of static RAM) which store data. Might not be the most efficient way (depending on your requirements) but it can be done.

https://en.wikipedia.org/wiki/Flip-flop_(electronics)#D_flip...
> Someone else with the same browser, OS, and laptop model would have the same fingerprint.

the collision rate of their ids is stated to be 0.05%

what they do is basically collect a lot of signals from the browser (audio processing stuff being only a part of it) and then compute an id on the server.
It's curious how the same stupidly simple market theories never apply in the inverse. Why is it that mass immigration doesn't increase rents across the rental market?
I wish people would spend less time trying to figure out how to slow down cars, and more time on making it safer for cars to go faster.
Of course, but so are almost all cancer treatments, and many cancers are still a death sentence.
Not sure I see a difference between thunks and futures.
Thanks for the time and effort you put into writing this comment.

> As many of the other comments here have said, this has been done before. You are repeating the mistakes of DCOM and gussying it up with a modern-looking marketing page.

Respectfully disagree, it's not really comparable to DCOM and CORBA. It contains a control plane which is stateful [1]. CORBA does have an ORB [2], which is close, but the specification does not allow for durability.

I do apologise for having a modern looking marketing page.

> You demonstrate a lack of understanding of idempotence on your marketing page, which is enough to dismiss your service outright.

I think we discussed this elsewhere in the thread where I gave you the implementation details that prove the claims of the marketing page.

> With all due respect, I'm sure you've put a ton of work into this, and you may even manage to sell it to some teams, but this has been tried and failed so many times in software development's history. It won't be any different now. This is very likely to cause long term harm to any team that adopts it.

It's actually open-source [4] and self-hostable, so teams don't have to "buy" it. I admire you confidence about this failing, and you might be right. But the reason why this has been tried before in the software development history tells me that the proper abstraction is somewhere out there. If everyone resorted to not trying something that failed before from a new perspective, we probably wouldn't be very successful as a species. Everything is a remix, after all.

> For anyone considering it, please make sure you actually understand idempotence and autonomy. Look into event sourcing. Study the fallacies of distributed computing. Check out the work of Udi Dahan and Scott Bellware. Run, do not walk from anything purporting to do the things that this does.

Wise words, but I'd appreciate it if you could dive into the way things are [1] [3] a little bit, and let me know if you hold the same views.

[1] https://docs.differential.dev/advanced/architecture/

[2] https://www.sciencedirect.com/topics/computer-science/object...

[3] https://docs.differential.dev/getting-started/thinking/

[4] https://github.com/differentialhq/differential/
There are times when I've wanted architecture diagrams to be ASCII in markdown, meant to be consumed through GitHub or in a Backstage portal or something. For me, the ideal workflow would be to just be able to edit those inline but still have cool editor features. Maintaining a separate file is just hassle, and it's hard enough trying to keep diagrams alive as part of documentation as it is.
Can someone explain to me how the BRC isn't bottlenecked on I/O? I don't understand how the CPU is the bottleneck.
> Why are mRNA vaccines the future?

This may well be true, but I’ll be far more likely to believe it when there’s an mRNA vaccine that’s anywhere near as effective as the best old boring vaccines.

(I admit that my personal favorite, not-mRNA, HSV vaccine candidate is from a company, X-vax, that appears to have forgotten to renew its domain.)

I’m also not entirely clear about the path by which mRNA technology might eliminate persistent infections. Maybe by preventing them in the first place? Maybe via CRISPR?
This channel is so, so important, I can't say enough.

Selections of this channel's content should be included in children's school curricula.
I'm the opposite. I think website = sanboxed, native = pownage so whenever I can use a website version I often prefer it over a native app.

I use photopea all the time now. it's available on every machine, even machines I don't have permission to install software on
Intellij (and all the other variations) has something very similar to this called [0]HttpClient. Being able to commit and basically just read the file is very useful. You can also do validation and scripting with it too.

[0]https://www.jetbrains.com/help/idea/http-client-in-product-c...
Getting Started Programming Spaceships
It was actually the other way around. The mandates were a reaction to the anti-vaxxer hysteria.
Coincidentally (or not) those also seem to be the words spoken during computer programming right before you figure out something you never understood before.
This is a rewriting of history. Politically extreme oppositional defiant disorder and a concerted effort to sow active disinformation are the roots of the tree that bore that fruit, not vaccine mandates. Mandates followed the oppositional defiance, not the other way 'round.

If you insist on blame--and I can get behind that to some degree--ravening shitheads with political (or, I guess, perhaps mere social-media view counts) greed in their hearts are where to look, not "you are, actually and in fact, rarely but indeed sometimes obligated not to help make things worse for your fellow citizens, and we will make it happen if you lack the civic culture to do so yourself".
This article teaches optics people about compute arch.

Which is maybe fine, but its not still not clear how to implement these components.
Maybe try Step CI (https://stepci.com)
Isn’t this also basically what happens to countless of our cells every day through natural exposure to viruses?
Miami Condo Collapse: New Security Camera Videos and Updated Analysis
How can you be sure that will produce better outcomes? Is better outcomes even the right goal?
> So as a user my preference not to be fingerprinted or tracked takes a back seat in the name of fraud detection?

the issue is murky for certain use cases. take payments for example. fingerprinting is used at scale in that field, and for good measure. you want to be able to know the risk associated with a user (chargebacks, fraud, etc).
Another interpretation is that it's trying to backspace everything it's ever sent.
I'm not sure whether or not I agree with what you're saying, but I will offer that Punish The Contrarian is the most popular free-to-play MMORPG game online, because all players who choose the Punisher role start with a free +1 point bonus against those who don't, so it feels like one is winning simply by showing up to play.
I disagree that 2024 is not the year of Linux on the desktop. You will probably have some trouble with Photoshop, since Adobe seems to hate Linux, but otherwise you will find that Linux is a very smooth experience. If you are happy with your current Thinkpad apart from Windows, maybe get a new Thinkpad and give Linux a whirl. You can always revert to Windows if Linux doesn't work.

My personal hardware recommendation would be a Thinkpad of some sort. I'm using a Thinkpad X1 Yoga right now. It survived a 4 or 5 foot drop onto a tile floor recently; I had to disassemble it to reseat the touchpad and fans that got knocked out of place, and the aluminum chassis now has dents on the corners, but the laptop overall took it like a champ. Even if you don't get a Thinkpad, make sure to go for something with a metal chassis.

I strongly encourage you to avoid Apple hardware as they solder storage. Soldered RAM is common enough that I won't complain about it too much, but in my case, I recently upgraded my Thinkpad from 512 GB to 2 TB storage for a mere $100 (Black Friday deals FTW!). Unless you are really good with a desoldering setup, there is no way you could do that to a Macbook.
I had something like this going for L2 cache misses a while ago
This is a fractally wrong post.
I just block Postman servers in my hosts file and run an old version that still allows offline/anonymous mode. Works perfectly for my needs.
This has a precondition: the existence of targets unique to the cancer cell. That's not necessarily true. In theory you can have cancerous cells that are (at least in the epitope-space) indistinguishable from normal cells. I'm not a doctor, and I guess (and hope) this is an usual case, but finding a truly unique and dissimilar mutation sounds pretty hard, training the immune system to detect it correctly without generalizing sounds even harder. Potential, sure, and I hope this proceeds and yields some therapies that are safer than chemotherapy, but we need to be realistic with what we'll probably get.
TPM’s reporting has identified as SACR members the president of the influential, Trump-aligned Claremont Institute, Harvard Law grads, and leading businessmen in communities scattered across America.

This lowers my opinion of Harvard