skysight-inc/HackerNews huggingface dataset:
This is fascinating to watch.

I understand that they get the proteins from PDB/ChimeraX, but how much manual process is involved to map and place the individual proteins? The paper says it gets the protein locations from CryoET tomograms, but I'd be surprised if these let you automatically identify which proteins are where, and exactly how to place them, and even less so how the ligomers bind together to form larger structures - for example, in the video the membrane surfaces are very smooth, and look almost textbook picture perfect, which suggests they come from a hardcoded model or are smoothed in some way. One part of the paper mentions subatomic averaging from the tomogram, but another mentions:

> From a tomogram (Figure3a), we select the particles and determine the orientation of the crown of the spike, as well as the stalk that connects the spike to the membrane

Is this a manual process, where the researcher is using his mental model of how the proteins are fit and placing/rotating individual proteins? Or do the tools they developed let this be automated. Both are impressive! If the former, I'm blown away by the effort it must take to make these kinds of videos.
We've Been Doing the Web Wrong This Whole Time
If you can prove me wrong, you can roast me mercilessly for my ridiculous hot take & I encourage you to share with 5 friends who you know would also enjoy roasting me.

If you see I'm right, please comment to share your embarrassment for ever having used JavaScript, and share with 5 friends who you want to share that embarrassment with you.
I don't think that's relevant to the argument about competition. Being able to pull (most) of their source code doesn't make it easy to write a competing browser engine. Why do you think writing a browser engine is an impossibly daunting task nowadays? Who made the web this way?
Yep, had several similar such occurrences and my mind is boggled every time. I personally welcome any opportunity to learn and improve, but many people apparently don't.
Some extra context for comparison: Talc is faster than Frusa when there is no contention, but slower when there are concurrent allocations. Both are much slower than Rust's system allocator. Benchmark here: https://crates.io/crates/frusa.
Really liked it! Especially the "get buy in" is really good advice-- always stressing how the effort spent on refactoring actually improves things, and WHY its necessary.

Something that's kinda implied that I would really stress: Establish a "single source of truth" for any release/binary that reaches production/customers, before even touching ANY code (Ideally CI. And ideally builds are reproducible).

If you build from different machines/environments/toolchains, its only a matter of time before that in itself breaks something, and those kinds of problems can be really "interesting" to find (an obscure race condition that only occurs when using a newer compiler, etc.)
Lots of people LOVE hot desking. I’ve seen work place advertise it as a benefit.
Do they have large talons?
R. Daneel was a later retcon though.
So the following things are basically happening or exist right now:

- we can map the brain structure using fMRI

- we can change the structure (or parts of it) using ultrasound

- we can (or soon will be) able to read thought patterns via LLMs analyzing brain waves

To me, that sounds like we are not far off from being able to take an iterative approach to live brain modification.

Both scary and fascinating at the same time.
The GP said nothing about keeping and maintaining it, only generating it. Use it to understand the codebase, then archive it or throw it out.
I'm pretty sure the BBB is there for a reason, unavoidably there will be some side effects.
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...the moment you land on a site and the page loads

I've been selling floor mops for the past 35 years. Here are the mops I choose to buy for my family. Click HERE now (for minimal useful information and a bunch more ads, and popup videos, and please PLEASE don't forget to sign up for our newsletter.
Avocados were definitely a known dessert treat back in 1970s Australia.
More like: it’s just as (or more) unethical to remain ignorant as it is to violate privacy. But yea. That’s pretty much the argument.
> It did not expand housing or lower the housing cost.

Unless we're losing 1.4 million dwelling units a year, housing is expanding: https://www.census.gov/construction/nrc/current/index.html

Maybe not as fast as we need/want, but it is expanding.
Have you really started a deal that took two years to close? Did the property just sit there for two years going unused until it closed? How did you know the seller wasn't going to bolt halfway through?

I've never heard of deals taking longer than a year - how does a multi-year transaction with federal funding even work?
Are the incentives not coming from the people paying the creators, rather than Google?
Wegmans has always had the bulk candy, nuts, etc. as far back as a I can remember, I've never seen coffee though.
Right, the radical change is showing the Second Foundation getting built (and it having interesting reasons, in part due to individual mistakes, why it is getting built very slowly in time) not that the Second Foundation exists.

It's definitely an interesting storytelling change, and probably for the better. Second Foundation in the books is very much a seat of the pants deus ex machina where Asimov seemed to write himself into a clever puzzle with no easy answer and cleverly solved it "at the last minute" with a retcon, then sort of took another trilogy and a half to complete the retcon and deal with the consequences.
The Effect of Parking Policy on How We Live
Haha, I was complaining about that as early as 2017 (though mainly for big price drops):

https://news.ycombinator.com/item?id=14705898

And don't forget, their 2022 Superbowl ad was just a (bouncing) QR code, and thus depended entirely on the link working, and yet they apparently didn't plan their SRE for the case where the ad actually works exactly as intended. My comment on the HN discussion:

https://news.ycombinator.com/item?id=30418317
You forgot:

0. People who can buy the finished home
> Fix obvious bugs.

Be careful about that. Hyrum's Law and all.
Couchbase adds vector search and mobile vector search
Don't forget that that 1.7 trillion was largely forgiven, especially in the case of some of the largest recipients. The president at the time made sure that there was absolutely zero oversight of the corporations that got money, and of course that's going to cause problems.

Yes, printing money wildly leads to inflation. Nobody is arguing that it doesn't. Giving the poorest members of society means the velocity of that money (or the M1 number) doesn't actually cause rampant inflation, as it stays in circulation because it is used quickly.

Giving 1.7 trillion largely to corporations who don't NEED it causes inflation. A corporation who sits on that cash (and then doesn't actually have to pay taxes on that cash, nor actually distribute it to employees) does cause inflation, because that's a whole lot of money just sitting around instead of flowing through an economy.
I used the same approach while designing a lock-free bounded broadcast log (as in a "RWLock<Vec<T>>"; a MCMP, append-only Vec). It's quite easy to do because it's bounded. However, I could not find a way to make it both unbounded and efficient.

Any ideas ?
The Buckland Review of Autism Employment
This philosophy emerged later, when GNOME tried to differentiate. In the first few versions it was as flexible as KDE, it had fewer trinkets only because they came later and had to catch-up. It was only with version 3 that they went "full Apple", when they adopted a somewhat-dictatorial style of development.
Comments Etiquette for Collaborative Docs
Banning micro-plastic sources from consumer purposes isn't so silly if it contributes to dementia and other neurological issues long term.

They're finding they stuff embedded in utero lining; your argument strikes me as the same old rebuttal to the things we can't political agree to study. You can't deny there is a lot of business momentum to keep plastics in production, no? And yet the more we learn the more checkmarks in the minus column for petro-chemicals accumulate.
I'm a bit obsessed about spreadsheets and as someone who's building something similar (but not identical), it feels great to see all these next-gen spreadsheets on HN.

Spreadsheets are hard to do and even harder to do right, so congrats on launching—although given your backgrounds I don't think you ever lacked the manpower to let this be a technical challenge ;-)

My initial reaction:

* It does feel pretty fast

* but spreadsheets on the browser always represent an inferior UX

* the data tables / formula tables are a solid idea

* no self-hosting outside of Enterprise makes switching to this harder than it ought to be

* limiting the free plan to 3 sheets feels like a strange decision
> please let's all get back to something vaguely sound and rigorous

Something rigorous would be to actually read the paper rather than stop at the first part of its title. The authors are not claiming their LLM is 1-bit.
Do you know of any cryptography implementation that sets the Data Independent Timing flag? We've been trying to figure out what others are doing about it, because as far as I can tell nobody is.

Anyway, not sure why relying on C/C++ would have helped us here.
Ever since 2017 or so, Amazon is running a global experiment on how far you can drive prices up, and reduce customer service, without loosing customers.

I highly appreciate Khan and what she's doing, it was loooong over due. Driving up prices without loosing clients so is, well, normal I guess? Why would that be a FTC issue?
I use KDE because it’s stable, has every feature I want, and uses existing metaphors I am familiar with.

In my circle of Linux users, a lot of the people that choose KDE do so because they don’t find the desktop layer interesting to hack on, and just want a tool for interacting with Linux.
This is an abberviated version of the same yes, I'm surprised though that the vimeo link isn't working without login. I don't have an account with them and was able to play it without issues.
That doesn't sound like a prison at all, it sounds like there are different tradeoffs. The closest thing to a "prison" is not being able to hunt/hike/etc. which I can assure you is simply not true and people in cities do that frequently, just with perhaps an extra hour of travel time.

Being isolated in an area that depends on a car for any movement but not being able to drive actually is isolating like a a prison, however.
I build custom setups with laser, fiber optic, SFP+ and QSFP28 switches and openflow routers, outdoor enclosures, airborne and watertight enclosures, low speed and high speed directional and gimballed mobile mountings, battery and solar 24/7 power supplies, drone carriers, etc.

>For all [rural] fixed locations I really wish there was fiber too

Happy to help you out here. Think bundeling many patched firmware Starlinks up to 10 Gbps to jump-start the rural backbone, then extend it for 100km for $10K. 36 years experience.

Our Fiberhood speciality is rural, easier, cheaper, DIY deployable and already in more locations than you think [1]. Guerilla fiber plus instant Starlink.

[1]https://www.researchgate.net/publication/309254511_Fiberhood...
They didn't even ask me for that, straight up banned my account.
Sure, companies never pay anything, their customers do.

But if your property tax was 200%, and a home-owner's was 1%, things would change.

Now the argument about what the "minimal available housing" should be would come into play, because people who could not buy no matter what would now be homeless ...
Should We Respect LLMs? Studying the Influence of Politeness on LLM Performance
Has Bjarne Stroustrup said anything about this?

Edit: Links found from https://news.ycombinator.com/item?id=39519062

https://www.regulations.gov/comment/ONCD-2023-0002-0020

https://www.federalregister.gov/documents/2023/08/10/2023-17...

These aren't from Bjarne, but are from C++ people.
At the time of this comment (edit: since this comment, they addressed this, check the replies), on your pricing page you have "SOC 2 Type II Security Compliance" not being checked off on the free tier but it's checked in the others. The same thing applies to "HIPAA Compliant and BAA" except this isn't enabled for free and pro plans.

What makes the free tier different here? Are you storing free data in a different area with many less restrictions on who has access to it? How do I know what I upload is safe from being analyzed or sold? Are you using this data to train any data models but only in the free / pro tiers that aren't SOC 2 or HIPAA compliant?
I disagree. I don't care what elm maintainers should or shouldn't do. It's not my problem, so that's not a question I want to ask.

I'm curious about why the same few, a vocal minority, spams every thread about elm with the same blog post. If you think we're dismissive, it's more because we don't want the discussion to be derailed for the umpteenth time.
My story is cited in the intro anecdote and I argue that the FDA especially is too slow for fatal disease treatments: https://jakeseliger.com/2024/01/29/the-dead-and-dying-at-the....
> the Justice Department had prohibited Apple and Google from discussing the technique.

A blatant 1st amendment violation.
I reject the idea that the software world is somehow unique in the "Configuration options create multiple products" idea. One need only look at cars to see an easy example of a similar frame being the base of several models.

Now, I think one could take the idea that an engine and a frame can both be seen as modules of a complete vehicle. But... that really just underlines my point that software is not unique here.
Windows Zero-Day Exploited by North Korean Hackers in Rootkit Attack
> * but spreadsheets on the browser always represent an inferior UX

What do you mean by this? Inferior to a standalone app? Inferior to some other design in general?
This GNOME3 bashing feels gratuitous. I like both KDE abd GNOME, in their own ways.
Which is another way of saying: it's gotta be a partnership. That generalizes across all business categories, right? Product and Sales/Marketing have to work together.

That's such a banal insight that it's absurd so many businesses screw it up (in either direction) so badly.
Ivanti attacks linked to espionage group targeting defense contractors
I mean, we have self check out at every grocery store and fast food place in Norway. Automation is coming for all the jobs.
nice. How do you track teh distance (walked or running?)
Pretty much, and its really good at it too. I should reread it's such a good book dude
Frog Chorus – summon a chorus of frogs from your phone
POTUS Will Investigate National Security Risks Posed by Chinese 'Smart Cars'
Like most of this thread, this is an enforcement problem. Insurance is way too cheap, and people just ignore it way too easily. Also, the minimum required coverage (in most states) is way way way too low. In most states it's as low as $25k bodily injury per person, $50k per accident[1]! A single broken arm can cost more than that in the USA. How on earth are we allowing people to drive a 3 ton death machine around carrying only $25k of insurance??? If someone carrying the minimum insurance plows into a car full of people, there is no way $50k is going to be enough to make everyone whole.

Finally, "accidents" that cause injury or death are treated way too lightly by the justice system. If you kill someone in any other way and get convicted, you're doing hard time in prison. If you kill someone with your car, you might not even get jail time if it was deemed an accident.

1: https://www.nerdwallet.com/article/insurance/minimum-car-ins...
> 3. Make the project enter the 21st century by adding CI, linters, fuzzing, auto-formatting, etc

I would break this down:

a) CI - Ensure not just you can build this, but it can be built elsewhere too. This should prevent compile-based regressions.

b) Compiler warnings and static analysers - They are likely both smarter than you. When it says "warning, you're doing weird things with a pointer and it scares me", it's a good indication you should go check it out.

c) Unit testing - Set up a series of tests for important parts of the code to ensure it performs precisely the task you expect it to, all the way down to the low level. There's a really good chance it doesn't, and you need to understand why. Fixing something could cause something else to blow up as it was written around this bugged code. You also end up with a series of regression tests for the most important code.

n) Auto-formatting - Not a priority. You should adopt the same style as the original maintainer.

> 5. If you can, contemplate rewrite some parts in a memory safe language

The last step of an inherited C++ codebase is to rewrite it in a memory safe language? A few reasons why this probably won't work:

1. Getting resources to do additional work on something that isn't broken can be difficult.

2. Rather than just needing knowledge in C++, you now also need knowledge in an additional language too.

3. Your testing potentially becomes more complex.

4. Your project likely won't lend itself to being written in multiple languages, due to memory/performance constraints. It must be a significantly hard problem that you didn't just write it yourself.

5. You have chosen to inherit a legacy codebase rather than write something from scratch. It's an admittance that you don't have some resource (time/money/knowledge/etc) to do so.
Bottle and can recycling machines are common in the United States as well, although only in places with bottle/can deposits.

Many recycling centers in the US use single stream recycling where the waste is separated into separate streams at the recycling plant. I'm sure this only works well for glass and metal items but I don't see any reason that it eventually wouldn't get better.
Cencora reports data exfiltration in cyberattack on pharmaceutical giant
Do air molecules in gaseous form colliding with the plastic contribute to micro-plastic production? Oxygen is a notoriously active element....
> then why not just say moulded gelatin foods have fallen out of style?

Because that isn't what I said or meant but just a parenthetical suggestion at what a better definition might be when I realised that it worked for the three examples that came immediately to mind and that I listed?

> with all of the modern baking shows and baking adjacent game shows

I explicitly excepted cake tins and pie dishes and the like, I don't think of that as 'moulding' and I don't think most people do either.
July 6, 2023, "What It Really Takes to Convert an Office Building Into Apartments"

> Big cities like New York have two real estate problems. Housing is scarce and office buildings are empty (or at least under-utilized.) So there would seem to be an obvious solution: turn the offices into homes. And indeed there has been a lot of talk lately about "office-to-resi" conversions. But it's very hard, for a wide variety of reasons. Zoning, financing, and then, of course, the operational aspects of the construction all need to be in place. So what does it take? On this episode, we speak with Joey Chilelli, managing director at the Vanbarton Group, a firm that's been involved with these projects for a decade and long before the pandemic upended both real estate markets. We discuss the challenges involved in actually pulling off these complex projects.

* https://omny.fm/shows/odd-lots/what-it-really-takes-to-conve...

* https://www.youtube.com/watch?v=HNkLcD3PKyk
I was interested to see this on the heels of the discussion about tipping/threatening LLMs a few days ago [1] (discussed here: [2]).

Based on the examples at the end of the paper, it looks like their inquiry was somewhat orthogonal to the tip/threat investigation. That is, the tips and threats can be done in a way that is polite, when "rude" is defined as calling the LLM a scumbag. Putting these two studies together, I wonder if the best outcome could be achieved by politely asking the LLM to do XYZ, offering a tip if it succeeds, and noting that terrible things will happen if it fails.

1: https://minimaxir.com/2024/02/chatgpt-tips-analysis/

2: https://news.ycombinator.com/item?id=39495476
To be honest, we may have done so unintentionally. It's a major downside to the idea of peace through trade that was popular in the late 1900s. While the countries you trade with may choose peace to avoid disrupting that trade, they may also decide to take all that money and goods and fund their military efforts.
i think before 10, you limit their risk such as walking out by themselves because they are either too short for cars to see in some blind spots or not have developed enough awareness of the world yet.

Other than that let them fall a few times and stuff in controlled manner and they get better at risk assessment. Otherwise they default to being risk adverse because you’ve been always telling them everything is risky
Tested earlier, still seems to be working fine. I can only suggest to try a VPN/alternative DNS?
This is a pessimistic, anti-progress perspective. As you point out, there are plenty of other problems in the recycling chain. But this is a small step in the right direction. And the investment here is pretty small too. $1.2m probably covered a handful of engineers for around a year plus the cost of tooling. Given that Heinz sells a lot of ketchup, I would expect that the impact/dollar here is pretty high.

Also, I’d bet that the new cap is cheaper than the old one. I’m sure that helped justify the investment to management. Kudos to the engineers who made this happen for finding a solution that is palatable to management and also makes the packaging more sustainable.
That may generally be true, but that's a beautiful building shown in the article; I hope they don't tear that one down.

When we're talking about some glass-box office building though, then by all means, just replace it.
Yeah but the self checkout hasn't and most likely wont' replace all human cashiers.
I enjoyed what we got in Season 2 of the "Brothers" of the pseudo-religion going out into the galaxy and sharing Terminus technology with already technologically fallen behind worlds. I wouldn't have minded more of that. I think that was at least a small hint as to how Terminus is going to wind up dominating the galaxy technologically.
A) No
B) No
C) No
Tell us about the stack you're using to build this. Also the biggest tech challenges you've faced and solved? But most importantly, does your family still use Google Spreadsheets?
> have said that it's basically orientalism and ornament and they've gotten rid of it because it's distracting

I like the books and the first film, haven't seen part 2 yet. But this has to be bullshit. Is it about orientalist ornaments or did the studio want to avoid a midwit outrage over the frequent use of the term "Jihad"?
Possibly, but the world would be much worse off for it.
He Got Bored. Built an Empire. Cracked the Formula for the Fastest Sport
TinyMCE Dumping MIT for GPL
TinyMCE was licensed under MIT but has just merged a commit that changes it to GPL
Your entire line of “argumentation” is based on half-truths and half-cocked understandings that is not based on historical reality. This, I suspect, has thoroughly skewed your understanding of how humans act and should be addressed in the next model version.
Glass bottles are considerably heavier and bulkier enough that shipping becomes a non-negligible expenditure of energy.
Indeed, I forgot to put that up there. The big difference between Retail and AWS is that Retail has obviously expensive ways to grow. And has to have an absurd float in the form of inventory to work. I think datacenters have a bit of that, as well. But I would be shocked if it was to the same level. AWS, on the other hand, seems to genuinely have trouble finding ways to spend all of the margin they pull in.