skysight-inc/HackerNews huggingface dataset:
The problem of non-selective cleavage of all terminators, whether they have been incorporated or not seems to be the most significant one. Is engineering a selective polymerase really the best solution here? If you don't top-up the reaction with un-cleaved terminators, won't the reaction become slower and slower as you go? The ideal solution is somehow have terminators that will only get cleaved after incorporation (maybe due to conformational changes); but I can see how that's probably even harder to engineer than a selective polymerase.

I can see that the complex microfluidics and reagent cycling can be a big added complexity/cost. The continuous process is definitely more elegant, but also seems really difficult to get right for longer read lengths and I wonder if it is really worth it.

What would be the potential benefits of the continuous process? I guess cheaper reagents since it is a one-pot process and faster sequencing speed since you don't need to cycle reagents?
Beware of the Big Tech "Bubble"
To be clear, I 100% agree. That's why I refer to it as "structural". No individual or even group of individuals is actively doing anything corrupt, but the overall structure creates an environment where self-interested individuals create an outcome that is VERY difficult to distinguish vs the outcome you would get from more obtuse corruption.

It's more akin to the Chinese concept of Guangxi (https://en.m.wikipedia.org/wiki/Guanxi).

The problem is that where Guangxi ends and corruption begins is a VERY murky question with no clear way of finding an answer.
I am with you 100% on this (see my separate comment which mirrors yours almost exactly). I like tmux for one reason: I can disconnect from a remote session and reattach later. If my internet connection is interrupted or or I just need to move to a new location, tmux is awesome for this. Beyond that, I really don't get the appeal of implementing terminal multiplexing at that layer. It's a job that can be done much better by a terminal emulator. ssh even has socket multiplexing built in, if you're inclined to use it, but it's only good for a little bit of a performance boost (quicker connection time by reusing an existing socket).
One can play infinitely more slow than he can fast though.
Some might say the same about hearing a chord change in a 600 year composition
You also have something on the scale of pounds of e coli in you. It’s just you never hear about it except for illnesses.

I wish the news included like 10 percent segments of random facts. Maybe biased towards relevant current events but not entirely so. Like I want to see a 90 second documentary about ghengis khan, a how it’s made segment, and the etymology of the word bubble.

All of my feeds are way too focused, there’s not enough discovery. And the “news” is hot garbage. Same problem with Amazon, oh you just bought a printer? Here are fifty more just in case.

I don’t know if this is driven by real metrics or just bad algorithms. I want fewer suggestions within 0.2 sigma of what i liked before and more suggestions 1 or 2 sigma away. And for the love of all things holy if you’ve shown me the same thing fifty times, maybe set that aside and try something else.
I hope you reflect on this post when the new compensation package is adopted by an overwhelming majority.

Sadly many poorly informed people lack the capacity to change their minds.
And it takes a staff engineer to know which system to refactor.
People are typically talking about pathogenic E. Coli when they talk about E. Coli in reference to food safety. I don't think that makes them wrong.

Also, there are over 700 identified serotypes.

https://en.wikipedia.org/wiki/Pathogenic_Escherichia_coli

https://en.wikipedia.org/wiki/Serotype
Unrelated: FS blogs used to be short, crisp and to-the-point. Now they get a bit ranty and preachy and seems like some of this is mined from ChatGPT. Whatever happened to the crisp editing :(
Do they work on mobile yet, all of them? Without that, it is not so useful for me as real investment of my time to make them; 60% of my screen time I wouldn’t be able to use them.
I feel like technology always has a "this is not what i want" problem to huge portions of users.
Why haven't we come up with amazing new ways of incredibly fast feedback?

user: "send feedback : i want to quickly switch between windows and I cant seem to do this"

developer : "Hey look here we have 3700 users who want faster task switching features" (submit task request to upper management) (approved)
a month later, "hey user 7 feedbacks in the last month may have been solved, slap the naked zuckerberg dingus in your home area to hear more"
Heh. Then there are those that say SQL already reads like natural language.

What happens if you feed the model with sql as input?
Kitty is pretty wonderful. It also has most of the features that tmux provides (and a bunch more)
In my browser (Safari on iOS 17, the second instruction was cut off by the email registration form field. You may need to move the instruction text higher.)

I’m unsure how this benefits me. Do I get a cut of the crowdsourced money?

How is the future video related to my video?
And lack of concern for the end product.

In large enough company, outside of engineering department end product quality or even business long term sustainability is often no one's concern.
In the Apple ecosystem, the SMS syncs to your Mac, Safari detects the code and autofills it in the web page, and then it auto-deletes the SMS when you're done for you. It couldn't be more seamless.
I install Lineage on the phones of the elderly at local care homes and any people who are interested in prolonging the life of their old phones.

Poor people can't afford a new phone every two years.

When in your 80's you dont need or want the constant nagging of apps pestering you when all you want to do is text and call your family and friends.

I use abd to delete/disable every unnecessary useless app and leave them with just 3 apps. Text, phone and contacts. No data or wifi either. A dumb smart phone. Much better than the ageist demeaning Doro big button phones.

They are all amazed how beautifully simple the phones are and with just one or two taps they can text or call anyone.

Have you ever watched an elderly person trying to navigate the complexity of a modern smart phone.
Not so smart!
we should very much not try to conform our taxonomy to our existing terms

I see this stunting imagination everywhere. Economics, science, nature, etc. Humans generally feel they've "captured" knowledge with a brief overview and disdain any messiness that might allow that knowledge "to escape".
> Does the CEO need to know these things?

In every case? No. Not every business, not every industry needs that.

In cases where the company builds machines that millions of people every day depend on to not die, yeah, the leadership should probably know some of this, if only to be able to realize when someone is trying to blow smoke up their ass.

Yeah, he should probably trust the people below him, but the cost of having that trust be violated is way too high. The consequences aren't just a bunch of people losing their jobs, maybe local business being depressed because the nearby widget factory closed. The consequences are airplanes falling out of the sky and lots of people dying. So he needs to be able to verify that the information being given to him, that he's trusting, is actually trustworthy.

And nevermind the economic effects here. If people stop trusting certain aircraft as being safe, they're not going to care whose name is painted on the fuselage.
I'm always interested in unique perspectives, but at the same time, English has a meaning outside any individual's concept of it.

> Newton was ... not a scientist.

That has a meaning, and its false. Whatever you personally think of it, Newton was a scientist. I don't love a wild goose chase.
Another good one for me is that a cubic light year or butter would immediately collapse into a black hole with a Schwarzchild radius larger than the observable universe.
Luckily those kids won’t go far academically. I can understand why one needs tutoring for IIT’s JEE, but SAT? Students in Asia and Eastern Europe send their LOLs. So kids who have certain talent can beat those who need tutoring for SAT one way or another, hands down
One big use case is the ability to attach/re-attach to sessions running on some remote host. When connection is lost, you don't lose the session and can easily re-attach to it
After reading Section A.1 (Data Collection and Network Construction), I wonder to what degree their analysis depends on MIDI encoding practices. For example, for a keyboard fugue, you could use one channel for the entire piece, one channel per voice, or one channel for each hand, with the voices moving between the two as a human player would play them. Apart from rare corner cases (especially in the WTCs), they would sound exactly the same, but I think their method generates very different networks for them.

And MIDI files might be a recording of an actual performance (with all ornamentals played out, chords arpeggiated to varying degrees, etc.), or try to capture an urtext edition as accurately as possible (leaving much to interpretation).
Professor William F. Sharpe's Thoughts on His Own "Sharpe Ratio"
Yes, I've found that you need to scrutinize the documentation, quotas, SKUs and billing statements quite closely, and you need to test everything before you run production at scale. I've seen unexpected billing due to an operation or resource using a different SKU than expected which didn't qualify for an account's discount, for example.
Next thing you know they'll be trying to make category 7 hurricanes official
Most wine is stores, or transported in this way at some point in its life. Most blends are blends from multiple vineyards, and are transported in big metal tanker trucks with plastic lining. Some are transported in big 500 gallon plastic totes. In my limited knowledge, only pretty high end wines are made by only ever touching oak barrels and glass bottles.
AT&T won that case: https://blockworks.co/news/att-crypto-sim-swap-lawsuit
Would you be willing provide a live demo (via web interface) - as a preludebto providing a similar training bot as a consultant?
This is very kooky.

One of the first virus discovered was Tobacco mosiac viruses. If nothing else, there's no question that viruses cause diseases in plants.
I'm glad you learned that lesson for less than $1k. I think everyone who's ever worked with large amounts of data in BigQuery has a story like that, and sometimes the number is six or seven digits.
> It's only because of closed source tools stuck in the stone age that the state of the art is to copy out of a PDF.

Not really. KiCad is open-source and a very capable EDA suite, for example.

The problem is that it's a really hard problem for which no one-size-fits-all solution exists. There's basically an infinite number of properties which are important when designing electronics, many of which will have to be nudged depending on your design. Capturing all that in a data format is virtually impossible, and any attempt to do so is likely to degrade into something unusual quite quickly once you get past the trivial stuff.

In my experience reading it out of a PDF is usually not that big of a deal, once you get used to it. For things like schematics symbols and footprints there are data interchange formats available - and there's a pretty decent chance these days they'll be openly available for the part you are using. But they always contain mistakes, and I find it way faster to just roll my own from the PDF than to copy it ready-made from a 3rd party and fix the errors.
There's no way the average person is washing their grocery bags in the clothes washer.

Sounds like that could coat your washer with microplastics that might end up in your clothes and against your skin all day. That may not be the best idea.
> Why not offer an agreement for off-peak use, and put profits into expanding capacity?

I think there is no such thing as off-peak in hydro power. It's a big water reservoir that you can open and close the tap at will.
After watching a bunch of reviews I feel like the eyes on the outside is the “Touch Bar” of the AVP.

Something that sounds cool in theory but Apple will eventually drop in future models as it just adds extra complexity/cost for little benefit.
No one rides trains anymore but they service a massive amount of our economic goods. If you want to buy a coffee, use your credit card.
At the time of writing of this comment this story is number one on hacker news front page.

While it’s an interesting read, it’s hard for me to want to view it as an interesting take because there is no indication that the writer has ever actually tried the hardware being discussed.
The spaceship in Poul Anderson's Tau Zero uses a Bussard ramjet.
I wonder how do they manage that with all the corrections needed like for astigmatism? That's a huge range of combinations.
Anyone curious about the style of composition should read about Counterpoint[0].

If you want a decent, comprehensive dive into music theory and composition you can pick up any old edition of Tonal Harmony.

[0]: https://en.m.wikipedia.org/wiki/Counterpoint
In the United States we still had McCarthyism and that led to a lot of accusations within the scientific community too. It’s always a fair warning.
Half the story?
Malicious NPM Package Targeting Roblox Users for Data Theft
lest we forget.

The word "Employ" means "to Use"

to expect anything more is just fantasy

Fool you once
Yeah that's the one thing I do use tmux for.
From the wsj especially, seeing as how musk is parroting gop propaganda about illegal immigration non stop. As if illegals weren't entering the country when Trump was president, or any other president for that matter.
I was looking into thumb-key. What differences are there? I noticed the same layout is available
> smaller projects with more distributed contributors

Smaller projects are either handled by one or a few engineers, with each looking after one or more disciplines. I can't see collaboration on a PCB as a thing.

For example, I have personally done electrical, embedded code, FPGA and full mechanical design and manufacturing on many products that can be described as one or a few PCB's with < 1000 components. Not that hard.

I am open to the idea that I just don't have the experience in a domain where more than one engineer actively works on a single circuit board. By "actively works" I mean, simultaneous editing of portions of the PCB with the equivalent of a team leader handling pull requests, etc.

I have worked on PCB's full of analog and digital chips in the 30 x 30 cm range (12 x 12 in) entirely on my own while other engineers worked on other boards that plugged into the same backplane. I have never worked on a single board where anyone else is running simultaneous edits. The closes I have gotten to that would be a power electronics engineer "blessing" a switched mode regulator design that I then manually integrate into my work (and so do others).

So, yeah, don't know. I'd be interested in hearing from anyone who regularly works in an environment where simultaneous team editing of a single PCB happens in the same manner as one might with something like VSCode and "Live Share" collaboration sessions.

Sorry, I just don't know if that proposal is realistic. Not my range of experience, which means nothing at all.
Or this one: https://en.wikipedia.org/wiki/Zeitpyramide
FYI, this doesn't work in Firefox, only Chromium. :/
Why hedge funds still make money with credit card data
It certainly wasn't like Pascal in 1969, given that the first release of that language was in 1970.

If it's 1969, and you didn't happen to have heard of ALGOL, what you know is COBOL, FORTRAN, Assembly, and maybe BASIC: then yeah, PL/I looks like a more modern version of COBOL.
It sounds silly, but it feels much nicer to skip the `style = {{}}`.

Plus, they all get their own class names, so it's a bit more efficient than the naked style prop, and if you edit one in DevTools, all its siblings are updated to match.
There's a mistake in the post regarding the cost to the company of selecting you (~$24k). They have runner-ups, and they most certainly didn't take down their postings yet, so they will not lose the $24k and start over again, they'll lose a bit more money negotiating with the runner-ups if they're still available, only if the negotiations dragged on forever would the cost keep going up for the company.
It’s a pretty awful note.

“ The company was turning over double digit (>$10M) revenue and had more than doubled the number of new product logos in 2023.”

Sounds like he was measuring the wrong things.

“I could say that this should not have happened, but I know that we are not alone in this market.”

Sounds like he’s justifying his failure by point at others in the market.

Written like a Wall Street trader. Oh wait…
Hmm I doubt it. The bigger the sensor the bigger the lens especially if you're not looking for ultra wide angles. I doubt much bigger is going to be physically feasible with apples focus on thinness.
Maybe? Or the bar will just be a lot higher for them since there will be less work at the entry level. Either way I think previous generations of SWEs will be at an advantage going forward.
No, it stems from North American use of ÷ for division, which is then ASCIIfied to %.
Upload product photos, get detailed, seo optimized, product descriptions. https://producks.ai/
There is this: https://en.wikipedia.org/wiki/Generative_theory_of_tonal_mus...

My impression is that it's not exactly mainstream. I'm also not sure to what extent it works for polyphonic music.
Then say vibes.
Are We All Too Cynical for Star Trek?
Made an app called Nerve where "players" complete "watcher" dare requests on livestream for money.
It’s going to be the killer app no one talks about. As usual.
The only food worth the trek is the Toxic BBQ
It’s fun being the hero, till it isn’t. Balancing one’s natural behavior with burnout is definitely a skill.
They're saying a fastball pitch-- 340 joules or so of energy.

The thing is, you need to be going implausibly fast to have a proton have a fastball level of energy. Even at .99999999 C, a hydrogen atom still has less than a microjoule of energy. You need a lot of 9's to get up to 340 joules.

1/sqrt(1-(0.99999999)^2) * (1 atomic mass unit * (speed of light)^2
1.05529895 × 10-6 joules
> It seems like even top EE who specialize in board design utilize rules of thumb rather than rely on simulation.

Yup, almost 100% this. Most parts of most boards are pretty trivial, and the design decisions you make don't really matter all that much. Unless you're working at a company the size of Apple, it really doesn't make sense to spend several hours of engineering time to figure out if that $0.001 decoupling capacitor is really needed.

And in the end it's often a lot easier to just build the thing and test if it works. We see the same in programming: it's technically possible to mathematically prove that some programs are correct, but in practice you can get 99% of the way there for all programs in a fraction of the time by just writing a bunch of unit tests.

Simulation is definitely done, but it's limited to the really hard stuff like antenna design or high-speed signalling.
Traditional frame construction is a highly optimized system. A skilled framing crew can put up a house in a day. And I'm talking a crew of 3 or 4 people. It's pretty hard to beat.
Do you not consider using CSS modules as using CSS?
I don't see how that is particularly relevant really. Reviews of the hardware being discussed are abundant. The point of this article is to share this look back - a book review, taking what we thought of AR in the past and relating it to the present. I had never heard of this book before. That's what I got out of this. MKBHD, Casey Neistat, and all the others have done a fine job of covering the present already.
Test Processing Practice Expt (ETL) DNS Data from WARC yy074
/*
Extract DNS Data from ARC_IA/WARC
Detect sitemap availability
0 - dontknow
1 - nositemapfound
2 - sitemapfound
*/
int fileno (FILE *);
#define jmp (yy_start) = 1 + 2 *
int v,w,x,y,z,request,response;
int dnsd,hosts,map,nsd,sqlite3,tinydns,http,append;
char addr[255];
char name[255];
char date[21];
int addrlen,namelen,datelen;
#include <time.h>
void bzero(void *,size_t);
char *strptime(const char *s, const char *f, struct tm *tm);
struct tm tm;
time_t t;
#define _X_ fwrite("https://data.commoncrawl.org",1,28,yyout);
#define _Y_(x) "x) ON CONFLICT(addrname) DO UPDATE SET date=excluded.date, sitemap=excluded.sitemap WHERE sitemap = x;\n"
%s ARC_IA WARC WAT
%option nounput noinput noyywrap
%%
^"1 0 CommonCrawl\nURL IP-address Archive-date Content-type Archive-length\n" {
if(http)yyterminate();jmp ARC_IA;}
^WARC\/1 if(http)yyterminate();jmp WARC;
<WARC>^"WARC-Type: metadata" jmp WAT;
<WAT>^WARC\/1. jmp WARC;
^q\n if(http)yyterminate();

/* insert PART 0: make URLs */
/* insert PART 1: ARC_IA */
/* insert PART 2: WAT */
/* insert PART 3: WARC */

.|\n
%%
int main(int argc,char* argv[])
{
if(argc)if(!argv[1]){
puts("usage: yy074 [0-6][a]");
puts("options:");
puts(" 0 - urls");
puts(" 1 - dnsd");
puts(" 2 - hosts");
puts(" 3 - map");
puts(" 4 - nsd");
puts(" 5 - sqlite3");
puts(" 6 - tinydns");
puts(" a - append");
goto x;
}
if(argc)if(argv[1])switch(argv[1][0]){
case '0': http++;break;
case '1': dnsd++;break;
case '2': hosts++;break;
case '3': map++;break;
case '4': nsd++;break;
case '5': sqlite3++;break;
case '6': tinydns++;break;
default: goto x;
}
if(argc)if(argv[1])if(argv[1][1]=='a')append++;
if(nsd)if(!append)puts(". 1 IN SOA from. arc_ia/warc. 1 0 1 0 1");
if(tinydns)if(!append)puts(".");
if(sqlite3)puts("PRAGMA foreign_keys=OFF;");
if(sqlite3)puts("BEGIN TRANSACTION;");
if(sqlite3)puts("CREATE TABLE IF NOT EXISTS t1(date INTEGER,addrname TEXT PRIMARY KEY,sitemap INTEGER);");
yylex();
if(v==4)if(response)if(sqlite3)if(z)
{
fwrite(_Y_(2),1,103,yyout);
fwrite("COMMIT;\n",1,8,yyout);
goto x;
}
if(v==4)if(response)if(sqlite3)if(!z)
{
fwrite(_Y_(0),1,103,yyout);
fwrite("COMMIT;\n",1,8,yyout);
goto x;
}
if(v==2)if(sqlite3)if(response)fwrite("0);\n",1,4,yyout);
if(v==2)if(sqlite3)fwrite("COMMIT;\n",1,8,yyout);
if((v==1)||(v==3))if(sqlite3)fwrite("COMMIT;\n",1,8,yyout);
x:
exit(0);
}
Very neat. Gut microbes are what allow termites to digest wood so well.
Doesn't this support the theory that viruses are rogue cellular messengers that left their hosts and started a genealogy on their own
I’d argue that’s a huge upshot. Countless software makers have an easier time making products with more homogeneity in the substrate.
It worked for me with Firefox Android.