skysight-inc/HackerNews huggingface dataset:
Yes, I agree. The trick is probably to find cell-specific SNPs located in regulatory regions so that there are no off-target effects. Massive screens using single-cell perturbations will help to gain some insights.
>>> 'internal'[::-1]
'lanretni'
That doesn't mean it follows that instruction. Or if it does today it doesn't mean it does tomorrow.
Would be nice if Figma worked on their pricing strategy or I fear a lot of companies and freelancers will probably be off-boarding.
Not really. I'm not fussed about leaving things unfinished when I die.

A few years ago I was deeply struck by an image of the late Grant Imahara's workbench [1]. It was cluttered with tools, notes, and unfinished business.

That's what I expect my desk to look like when I die, too.

[1] https://news.ycombinator.com/item?id=23830450
.lan might be easily misspelled as .Ian (or .1an), and the three letters look like a "normal" TLD. If anything, .local might be a better choice.
Alternatively, a few of these internal TLDs (.internal, .local, .home, .dev, .lan, ...) should have been reserved from the very start and then we should have intentionally leaned into the explosion of top level domains because shoving everything under .com was always kind of dumb. (But yeah, arguably what actually happened was a little bit the worst of both worlds and we get to deal with all kinds of fun growing pains until everything is brought to the new standard and hopefully we can stick with that.)
That's cool and all, but I didn't say classical liberalism.
Honestly, do you have a better suggestion?
What makes this a four-point egg if only the first three points are required to derive the rest of the shape?
Previous discussion: https://news.ycombinator.com/item?id=39196390
Funny enough the common wisdom in the Navy is that you eat much better on smallboys (destroyers, frigates, etc.) than on a carrier.

I knew a guy whose brother worked as a chef on the Charles de Gaulle (France's only aircraft carrier), and I bet the cooking there was incredible. The thing probably has a dedicated wine deck.
Landlords have the opposite problem on the west coast:

Instead of the gov subsidizing landlords, private landlords subsidize the government.

The rental protections give renters a softer landing for non-payment on the landlord’s dime. Landlords literally have to pay tenants to leave. The "cash for keys" money comes from the backs of future tenants.

Also, for most of the usa now, it is cheaper to rent than buy. My mortgage, taxes, and insurance is way beyond what I could rent my house for. It makes zero sense to create more rental properties.
> Why do you need to change existing VM in any way? Having an idle VM for function A should not prevent the host from instantiating new VMs for function B. I still do not see where is the cost of an idle VM.

Because the host can only run so many VMs. What's being described is host resource exhaustion from running idle VMs.
My fun RavenDB story: I briefly used it for an analytics (music royalty data, not advertising) solution somewhere late in the 1.x release series. Ayende (the initial RavenDB author) was/is an avid blogger, and made a really good case for their product in the .NET ecosystem.

It did not... go exactly as planned. Initial tests looked OK, but when I did testing with actual users, there were huge issues right away. Like: OK, I just ran your ingestion pipeline. What do you see? And the answer was 'well, nothing', or 'ehhm, a lot less than I expected'. These issues turned out to be pretty much impossible to fix: there were no real errors, but the data just seemed to... disappear randomly, even in a simple single-node cluster. I got community support involved in a bunch of particular issues, but nothing really helped: the aggregate numbers we got never added up to what they should be.

I then migrated the whole thing to a single SQLite database. That file is, as I write this, a good 2TB in size, and still performs as well as the day it was deployed and never had any unexplained-number issues, without any changes to the surrounding code. I did eventually move away from the .NET Entity Framework (as that did cause some rare, yet unexpected and hard-to-fix concurrency issues, but those were hard crashes and not silent data corruptions) to a hand-rolled entity mapper, but all has been good since then...

TL;DR: databases are very hard, and fashionable choices are not necessarily desirable.
For me, “beautiful” and “multi-platform” are opposites.
It's not devs who are overpaid but everybody who is underpaid compared to the top. The current economy is a pyramid with honestly a lot of similarities with a ponzi scheme. I'm not saying outright that is one because I'm not sure myself but you could make a lot of parallels for sure.

You are much closer to these lower paid jobs than you realize.
As a resident dad joke expert: Can you explain what exactly is a 'dad joke' about quoting a line about wishing someone to die slowly? Where's the joke or the funny? Where's the cringe pun?
Uhhh, when the deal is for a $55bn package, an executive should pay a lawyer to make sure that that sentence is included, and ideally that it’s truthful if included. Delaware is the most shareholder friendly state for business and has so much clear precedence it makes operating a business easy. If you fail at that basic level of governance, it is either idiocy or malfeasance. Can’t have it both ways.

Also, nobody serious is talking about moving companies out of Delaware. Elon is tweeting about it.
Funny company, creates problems for itself to solve.
Instrument and trace applications with the OpenTelemetry collector
Why don't you try leaving your laptop on a park bench for a couple of days? Maybe because not all people are like you?

And even more people, most people I would say, are not right-wing absolutists and they in all seriousness believe that it is the employer who robs them when they do the agreed work. So, in their minds, they don't even consider themselves doing anything wrong, they are just taking the opportunity to get a little compensation for what was stolen from them
I would argue he's the first to just buy one of the biggest social platforms so that he can show his ass on it. Probably not the last one, that we can agree on.
Normally this is self correcting.

In most markets when a single participant defects from a cartel they can flood the market.

When 70% or housing is under control of a single pice of software the other 30% can’t flood the market.
A few (1-4) dedicated, focused hours of practice/learning per day, every/most days. Review how well learning/practice is going periodically. Adjust as needed. Repeat until at desired level.

You're not going to get 12 good hours of practice every day. At least half of those hours are going to end up pointless. They might be beneficial at the start, but that's just beginner gains and will fall off.
> The better analogy is probably something like the Apple Watch.

first apple watch was afailure and immediately fixed by the watch 2

>Apple made the first mainstream acceptable smartwatch by smoothing over a lot of the complaints about their competitors,

if anything apple set back smart watch development, the real groundbreaker was Pebble, but thanks to apple the smart wtach market is a stagnant perpetual compromise to justify low battery life with overpowered chips and bright screens, when all we really want is week-long batteries, e-ink always on displays, and physical buttons to work well.

i say this as an owner of at least 2 apple watches over the years. pebble never had a chance, but android's watch software has always suffered on trying to play apple's game instead of finding a true advantage
I was unable to verify if this model is trained only with public domain images? Anyone found this information?
Indeed. Was curious, took a look, and it uses the same widgets as everything else.
I actually see this as a strong reason to stay.

Again the issue isn't compensation and whether it was too much, it's that the shareholders were mislead. If the board had disclosed they had a conflict of interest, and the shareholders still voted for the package (which I believe they still would have), it would be a moot point, but they did not. They didn't follow the rules, and that has consequences.

Laws and contracts aren't worth the paper they're written on if they're not enforced, and failure to follow the law, which they were all aware of, has consequences.
Identify who you and society views as the masters / what "mastery" is

Immerse yourself in their world and surround yourself with them on a daily basis if possible (where/how they work, where they train, where they hang out, what they do)

Create a super tight, iterative feedback look where you can make measurable improvements daily to your current skills, ideally with a testing or competitive component with scoring system or methodology - trial/error and experiment, but quickly

Debrief after these sessions on how it went, what was improving, what could be better, what feels completely off and difficult. Take appropriate time off to digest what you did and avoid burnout

Supplement with theory, books, video review (if applicable) and studying in addition to training and performing so you become a student in the craft

The goal is to get to a point of exponential acceleration and improvement to get you to mastery quicker by determining the pareto 20% skillsets and field experience ("inputs") that create 80% of the output value to get you to that 95 percentile, and double down on that once you've figured it out (and have validated that from the masters).

I personally think chasing mastery without deep burning passion for the thing is dumb and a waste of time because most top performers are probably 90-95 percentile pseudo-masters anyway and just lucky/well-connected. You might hit a point where the masters possess something you don't and never will, so it's crucial to understand that early (like a physical or genetic trait that you are born with or optimized for idk). Assuming everything above is in place, and you have unlimited $ and time commitment to make it work, I estimate a dedicated and focused 8 hours, every day would probably take 1.5-2 years to get to mastery, but YMMV.
I would love to see metros in every reasonably sized city but it's going to run into the built in sprawl problem of US suburbs making it very expensive to run lines out to the outlying suburban areas at high enough density to make them viable. Best work around option I suppose is to build them out to the edges of the city and build a big park and ride infrastructure.

I've long thought of the issues with public transit in the majority of US cities as being trapped at a local maximum where we're forced to implement inferior solutions because we're so far into the car infrastructure getting people to abandon their suburban homes to move to a more dense less car dependent urban structure until the underlying shape of cities would adjust to denser clusters again if they ever did.
Again, progressives oppose development regardless of affordability. They, for example, opposed amending the city charter to exempt affordable housing projects from discretionary review. They are suing UCSF over hospital expansion and opposed it constructing new housing for its staff. They organized against state bill SB35 and various density bonuses that allow for the construction of new affordable housing. They opposed the height and density proposed for a 100% affordable housing project through HANC and dragged proposals for redevelopment at Potrero Yard and CCSF through decades of process. Progressive political consultants worked for Livermore NIMBYs to spin a lawsuit against a proposed downtown affordable housing project. I could go on.

20 years ago, progs would admit outright that they thought new development was undesirable. Since, it has become more inappropriate to say that out loud so they dress it in concerns about only supporting housing under economically infeasible conditions.
Darn, I was really hoping they'd repurpose .test or .invalid!
It’s almost as if rich and powerful people are often insufferable asshole narcissists. We reward that behavior in spades.
> So, how does ".internal" work? I mean, it's just a hostname, and DNS responds to queries about hostnames.

I don't think this is the normative intent but you could certainly say that this TLD is reserved for use with the private IP range. That would mean that a) local resolvers would not forward requests to internet resolvers and b) local resolvers can reject records pointing to non-local IPs. That's not suuuper useful because you wouldn't get an answer anyway.

What would've been useful roughly 40 years ago is for ICANN to do something like this and also say "oh, and btw., domains under internet TLDs CANNOT resolve to non-internet (local, private) IPs". That would've preempted DNS rebinding and all related attacks.

It's of course impossible to do now because the "best practice" for the last ~15 years has been to register an internet domain and then use it for your internal network because there are no private TLDs and any TLD you come up with might be registered by someone else and suddenly become attacker-controlled over night (troublesome because now VPN leakage, which none of the Expensive Enterprise Client VPNs address, allows someone not-you to easily and globally impersonate you for leaked traffic and it's not even a rebinding attack in the narrow sense).

Arguably the "Old Guard" of IP networking did "a little oopsie whoopsie" with their "Thou shalt have no other networks before me, IP, your god" commandment (the idea that the IP stack exists to support exactly one network, the internet).
> I think it is abhorrent borderline criminal to place yourself at the centre of the Internet experience, and one day decide to make it shittier for everybody because of short sighted lust for money and inept PMs.

Putting into words the thought I’ve been having recently.

I think Google is winding down on search. I wonder how important it is to them these days. There’s no way being this crap is not intentional.
in general people have always saught a way to not have to look at each other in public. before phones it was newspapers and magazines as the social scourge of anti-social behavior
It might just be me but I don't think we should structure the economy around how easily founders can sell their business to escape to the next one. All that has done is make mega corps bigger and killed competition.
Do NOT even think about the "10,000 hours". It is a bullshit made-up number from Malcom Gladwell misinterpreting some research.

The actual number is vastly different depending on the specific field, and what you count as hours spent. E.g., in the ~decade it took me to get to top international ranks of alpine ski racing, if you count just time 'on the hill', it was probably 15K hours, but if you subtract time on the lifts, it was 3k, and time on track in my best event, it was <100 hours, but if you add in physical training, running, weights, etc, it was probably 30K hours).

The same goes for becoming an expert software programmer, sportscar racer, or other skills I've gained. In some, I'm far under the 10k hours, and others far over, and a HUGE amount depends on what you count. E.g., in starting out sportscar racing with Autocross events, I learned some bad habits that needed to be unlearned, but I learned a lot about just organizing, packing, & prepping for an event. So how do those events count? Do we count the days prepping before the event & traveling to it?

Yes, "seat time" or "inside the helmet" time counts. But those "10k" numbers are BS. Some learn faster than others, faster in some sections of the knowledge base vs others, better/worse training programs exist, better/worse coaches, etc.

The elements I've found critical are:

Find the absolute best teachers/coaches/mentors that you can. You will need to learn something, and I've found it's best if you can get it straight from the top. They are often not available, and there are often some deep experts that are obscure, you just have to find them and.or luck into them. OFC, you don't know how to judge from the position of a novice, but look for a focus on understanding how it all works, vs anything flashy (in fact the more anti-self-promotional they are...).

Practice time with good feedback. Use every tool at your disposal to get actual feedback on whether you are hitting your marks or not. The tighter the feedback loop, the better. Having video feedback is better than not, if you can watch it instantly, it's better than in the evening, etc. Actual instrumentation so you can see live data can also be critical, but use it to improve your internal sense of whatever is being measured, don't use the readout.

Good, but not great, equipment. Poor equipment will give you bad habits, so get advice on what is good enough to prevent that. But don't spend on the top-shelf equipment until you really understand how your middle-of-the-road equipment is holding you back. This will be different for each person. As you gain mastery, you'll need to focus on what equipment improvement will produce what quantified result for what costs (dollars, upgrade time, re-learning time, etc.).

Have fun!! Do not make it a slog. There will always be dreary and discouraging days, but it the fun days that keep you going. Enjoy the process!!
Well, there are two pieces. The first piece is establishing that 'the groups' were doing something wrong. The second piece is the usual struggle about the responsibility of big tech to police and moderate what goes on in the fora that they own and generate their income from. Attention is skewed toward the second question because big tech has the deep pockets, but both questions involve nontrivial moral issues.
I got downvotes for not showing the calculation, fair enough, my mistake. I understand the frustration there. And yeah, you've got to check ChatGPT's work and ask for clarification to understand what it did and why.

That said, I disagree with the assertions made in your post. ChatGPT is a great tool for saving time in doing simple research and calculations, as long as you double check it. It wasn't a year ago, but it is now.

I know, I'm scared by it, too!
I highly recommend Ultralearning [1]. It does not talk about hours required to learn something, but how to define your goal, plan out the study, and then immerse yourself into the task.

https://www.scotthyoung.com/blog/ultralearning/
Same. Hi, Apple! :D

I'd love to do more work with predicates in general. That's an open research problem I've been noodling on for years. Pretty much any SQL DB would be a good candidate for that work!

I'm gonna be a weirdo and say I actually loved Fauna's FQL. A little Lisp-ish functional language for queries is a great way to interact with document-structured data. SQL is fantastic for sheer breadth, though its specification is a nightmare and actually writing portable SQL is real challenging. One of those places where a stronger spec and conformance tests would have really helped.
See Figure 15 on page 8: https://web.archive.org/web/20200618202007/https://www.dynam...

The egg is constructed of four distinct arcs based on four different points, plus two of them mirrored.
Time Machine + Pyramid = Tomb Raider

Tornado + Fish = Sharknado

and Terminator, Dark Fate, Mad Hatter... but I forgot how.
Give polymelia a hand!
I think that misses the point that most people have on this topic.

You can support the right of people to express their opinions, but disagree and regret what those opinions are.
Little Alchemy might have itself been inspired by an earlier game:

https://archive.org/details/msdos_Alchemy_Game_The_1997
Compose Multiplatform - I already starred it on Github but forgot about it.

Nice recommendation. Only by looking at the video do I feel that it appeals more to me and my needs than Flutter.

CM for iOS is still in Alpha.
Both. Oil rigs in US territorial waters actually qualify themselves as Jones Act vessels. But I am also sure they don't mind paying the costs to charter US ships when needed or get ships from further afield.
Do these poor opinions really matter? He companies are still the top desired destinations for STEM graduates. Endless supply of people to grind that results in him providing products/services that others can't provide. This results in increased dependance on his companies and him.
There are four points inside the egg.
Implausible to me. Keeping that team going would put pressure on Figma. My read between the lines is that Adobe negotiated a partnership before ending talks.
Cool. I am running this on M2 Max 64GB. Here is how it looks on my terminal [1]. Btw, the very first run after downloading the model is slightly slow, but the subsequent runs are ok.

[1] https://asciinema.org/a/fFbOEfeTxRShBGbqslwQMfJS4
Note: This recording is in real-time speed, not sped-up.
Stay in San Jose! There are some pretty awesome events happening in the South Bay - albeit not as much as SF proper:

I built http://fogcity.events/ to help me find tech events around the Bay, hope it's useful to you too.
That feels very good! I've messed with Kotlin multiplatform recently and it's interesting.

I wonder why there is no desktop version.
> The "magic", as I understand it, of the 192.x.x.x network is that the Internet "knows" to not route it. Networking isn't my strength, so I don't know where, or what part of the my local network decides that 192.x.x.x can't be routed, and so doesn't.

First of all, it's 192.168.x.x, there are other networks which begin with 192 and are not treated as internal networks.

The trick is simple: it's not "the Internet knows to not route it", it's "the Internet doesn't know how to route it". These ranges (there are others, like 10.x.x.x) are reserved for private use, and will never be allocated for an Internet network. Since there's no network announcing it (and if some network mistakenly tries to announce a route to these addresses, they will be filtered since everyone knows there shouldn't be routes for it), any attempt to send a packet to it will go nowhere.
I might be convinced that founders tend to be charismatic (they convinced a bunch of people to build their dream when it was just a dream, after all), but your run-of-the-mill CEO certainly isn't.
The original title on HN said that there was a bug that applied on five days out of the year. I contend it applies more often than that.
It's also affected by the fundamental barriers to entry in offering a competing product - homes don't get built quickly and people can't move that easily.