skysight-inc/HackerNews huggingface dataset:
I'm not sure if they've said publicly what immunotherapy they used. I have seen it referred to as a combo, so I would guess ipi/nivo - that is Nivolumab (Opdivo) + Ipilimumab (Yervoy). They've been trialling those as neoadjuvant for melanoma: https://melanoma.org.au/paper/neo-adjuvant-immunotherapy-eme...

Nivo is generally well tolerated, ipi less so. I only got to my 2nd cycle of ipi/nivo before we discontinued it. (I'd already had more cycles of nivo on a trial.) It can have neurological effects and encephalitis in rare cases, so maybe that's what they are referring to. I wouldn't say "poison" though.

As it happens, Prof Long is my medonc. We don't sit around chatting about Richard though, she's a bit busy on clinic days!
It is also notable that the Mac was stagnating just like the Amiga around that time. The successor to OS 9 was delayed for years and years before being cancelled. The hardware was getting more expensive but with only small incremental improvements in speed or capacity. The Centris and early Performa lines were just so mediocre. The 68k architecture was stalling out just as Intel was blowing everyone's doors off with x86. Jobs made a bad bet with PPC, but it was still way better than 68k and gave them enough breathing room to keep up with PCs for a bit.
I think it’s a smart option. Fair chance there was a LOT of thinking that went into it.

For example, wondering about the characterisation of it with processing in the battery appliance. It would be “an expensive portable device with a dumb headset screen”. Could someone else sell a different headset for the device? Could they sell a Linux machine that is good enough to power the headset? Might people just want one or the other, and bitch about the cost of an ARM based mobile PC that burns up your bag because it has no free-flow air?

Might be Apple releases pricy larger batteries. Or some cable that allows you to hot-swap them. I see there is a cable where you can plug the headset into your Mac for development.

They hopefully considered the multi-year evolution of it, not just this year’s version.
I think WSL2 makes Windows far more tolerable. The VS Code remote development extensions integrated nicely and docker+compose is a treat to be sure.

I'm not sure I could go back to using Windows without it... I'm fine running Mac or Linux though.
Second Reality certainly put the nail in the coffin.

https://www.pouet.net/prod.php?which=63
It's probably tidally locked, so the day will be the same as the year.
Fair question. Yes, the product works fine and has been in service in a demanding industrial setting for a year. To make it work we had to write portions of the code in assembler. Extracting performance out of Python is a losing proposition. You are starting out at somewhere around 70x slower than C. We thought MicroPython could pull it off. By the time we understood it could not, there was no way to start over with C.

Things that are trivial to code in a performant way in C are impossible to code in Python. A simple example of this is a cyclic redundancy routine. We had to write those in assembler. Also, garbage collection was problematic, even controlling it manually. If I remember correctly, it took out a 5 us chunk of time.

We had to resort to such things as allocating large buffers globally to avoid allocation/de-allocation issues, etc. This was done mostly by declaring global variables as tuples (due to the simple memory structure) and then accessing them with assembler routines. The immutability of tuples only exists within the confines of Python, outside of that, it’s just memory. This approach resulted in massive performance and memory utilization (reduction) gains.

Beyond that, the entire codebase was a single function running a state machine, this to avoid costly (time and resource) function calls.

Eventually the thing starts to look like a typical bare metal embedded system where you create a round robin scheduler, etc. At that point it is very hard to justify using Python for anything, in fact C is far easier.

Code like that quickly becomes something that is hard to maintain, enhance and evolve. It became very obvious that we had to switch the product to C as soon as possible.
Oh my. I’ve fantasized about this for years. I assumed that physics would not be on my side for this one. I am going to be watching these tonight.
This math makes sense because grocery stores only buy broccoli once and then sell it over and over again for theoretically infinite profit. $1 spent on a broccoli over a year can be in the millions due to this phenomenon
I'm not sure I consider any apps on either to look native at this point.

I'd rather just have a, Material or Fluent UI in either , the latter being current windows design style.

They've both changed so much over time along with a mix of applications applying different design styles all around.
> if they still want to be relevant in the non-enterprise web game

They don’t. Microsoft makes products for companies who will pay for software.
Related ongoing thread:

A brief history of the U.S. trying to add backdoors into encrypted data (2016) - https://news.ycombinator.com/item?id=39244254 - Feb 2024 (119 comments)
Do you mean B12?
Must be something local to my network or my isp then. Still doesn't work and I tested it on a few devices now. Really weird.

Edit, works on mobile so definitely something specific to my wired internet connection.
Proper VR is an important aspect of the device. The main focus is on the "spatial" AR-style experience, but there's also a lot of focus placed on being able to be in a completely virtual environment in both the marketing materials and the OS. I don't think something which "works pretty well but doesn't quite become completely opaque" sounds good enough, especially for something whose only real advantage is possibly slightly improving how the wearer looks to others.

For a different product that's glasses instead of a VR headset, sure, it might work (although I don't see why you'd want to go semi-opaque at all with glasses really, it won't be close to an immersive VR-style experience anyway?)
Looking Glass Go portable holographic display to view your 3D spatial photos
When I want to go to sleep I put on an eye mask on the plane, or I stare like a zombie at the screen on the back of the chair in front of me. Either way I have noise cancelling headphones.

Honestly, I just see something like a headset just making my experience a bit more personal, which isn't a bad thing.
What exactly isn't survivorship bias?

Everything can be put in that bucket. Being born without autism, becoming a doctor, engineer, start-up founder, successful athlete et al.

They can all be abstracted as lottery tickets.

I think the survivorship bias arguments sweeps under the rug the fact that we might be able to learn something from successful people.
Microdot: A web framework for microcontrollers - https://news.ycombinator.com/item?id=39111276 - Jan 2024 (1 comment)

Microdot: Yet another Python web framework - https://news.ycombinator.com/item?id=38834156 - Jan 2024 (26 comments)

Microdot - https://news.ycombinator.com/item?id=38156060 - Nov 2023 (26 comments)
Venture capital is where we rent wrong. they are to startups what PE is to developed companies.
I don't think it is that smart - matrix headlamps have been around for ages in "dumb" (albeit luxury) cars for years and years in europe
Hell lets not forget trying to do this back in the Mono days when Microsoft specifically didn't want you to run .NET on anything but Windows.
Yeah, economists sometimes call it "prime age."

I'm not sure what you mean by "represented"? Someone who doesn't have a job in order to be a caretaker or keep up a household would count as not employed, even though those people are still doing work. (The same would apply for people without jobs and spend their time in school or volunteering.)

They do ask why people aren't working in government surveys, so that information is available to analyze. I wasn't able to quickly find an overall recent figure, but there is a figure for people who are technically in the labor force but haven't looked for work in the last month: https://www.bls.gov/web/empsit/cpseea38.htm. And I also found an older figure: https://www.bls.gov/opub/btn/volume-4/people-who-are-not-in-....
Anyone using this in production?

Is there any catch?

Site says its opensource. Are there any loopholes or critical choke points that necessitate shifting to something paid?
Curcumin has been studied for thousands of years. And there are tons of independent work that has zero relation to Aggarwal
eg https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781139/

https://www.frontiersin.org/articles/10.3389/fnut.2022.10402...

It's a valid idea to critique Aggarwal for plagiarism but counter-productive to completely debunk the years of research that has gone into curcumin by other researchers.
A laser-guided bomb destroyed a helicopter in combat
> Those who call for elimination of cars are privileged enough to live in Seattle and don't seem to recognize other's do not live in Seattle (or commute to Seattle from where most public transportation is not effective, viable, or possible).

I believe you fail to recognize that a lot of people who don't drive don't live in Seattle. Whether or not someone drives is not always by their choice. I have friends who are physically incapable of driving, yet because drivers tend to outvote and outweigh non-drivers politically, those friends are denied the transit service they would really like to have. And even when it is by choice, nothing says that Yakima or Spokane or Port Angeles can't have transit; most of them do!

I live in Seattle. My wife and I were born here and we will hopefully die and be buried here. It is our home. I have lived through decades of transit that would make a New Yorker howl in peril. It was not so long ago that our idea of a frequent bus route was every half hour, and the light rail (that began running after both of my children were born) stopped in downtown and at 11pm.

Seattle residents aren't a monolithic bloc but, generally, our push for fewer cars is because cars, and especially those cars driven in from places that do have quality transit to reach the city, cause a lot of problems for people outside of those cars. I really, really want to make it to retirement without being run over by someone driving into town who's late for a sporting event.

> Yet, it isn't viable for the vast majority of Washingtonians.

Not driving can be viable! It is viable, if not as convenient, in places you wouldn't think and might even consider are "too rural" or "too spread out." The fact remains, there are a lot of us in Washington who don't drive and, bluntly, I don't appreciate us being insulted or accused of having an excess of privilege or living in a bubble.

There may well come a day when you are not physically able to drive and I wish very much for you to have a robust transit and sidewalk and low-speed city setup that enables you to have independence and access throughout all of your days.
Difference is video is captured at all time since camera is on at all times for tracking. It's icky not knowing if you're being broadcasted while making eye contact as more than background character. I suppose that's true with audio being recorded as well.
The tooling for .Net in Linux and Docker has gotten pretty good. Also, Avalonia and Uno are both pretty decent options.

I'm not expressly opposed to electron like some, but I think efforts closer to native should be made more often.
Legally speaking, it didn't really matter. But symbolically, having the feds argue that a book constitutes "munitions" would be bad optics for them in a way that is more understandable to the average American, compared to more legal arcane arguments about software having 1A protections.
you didnt tell us why this is a bad habit...i personally dont see anything wrong with that
> Though I personally find having a conversation with people who won't take their airpods out is a sign that I am having a conversation with someone who devalues interacting with humans.

And that's a generational difference.

You and me may feel like that but a lot of kids these days don't.
The most interesting thing is how hard the true believers find it to let go of the past.

I bought one of the first Amigas - I own 2 Amiga 1000's and several others.

But for me they are nothing but items in a curiosity cabinet. Other people seem to deeply engage emotionally with some sort of alternate fictional future in which technology X or technology Y was recognised for its true destiny and never defeated by IBM/Microsoft whoever.

Computing moved on an other systems became much better. Don't waste your life living in the past. Just drop that dead technology and move on and stop investing yourself in a fantasy world.
If getting grades is too much for adults, imagine what it does to children.

Suicide among young people over grades and exams isn't exactly rare[1], but only when a teacher collapses under that same pressure we need to have a talk? About grading the adults?

What a strange world we live in.

[1] https://www.theguardian.com/society/2017/jul/13/suicides-by-...
Apologies for an extremely layman question, but what relatively accessible book could one read to understand all the formulas and acronyms in this paragraph? I mean to take them in as tools, if that makes sense?

In this context, we report on the discovery and validation of TOI-715 b, a planet orbiting its nearby (42 pc) M4 host (TOI-715/TIC 271971130) with a period
d. TOI-715 b was first identified by TESS and validated using ground-based photometry, high-resolution imaging and statistical validation. The planet’s orbital period combined with the stellar effective temperature give this planet an installation
, placing it within the most conservative definitions of the habitable zone for rocky planets.
> in addition to the latency of serializing things over the cable

That doesn't add meaningful latency if bandwidth is sufficient. A 80Gbps bidirectional link (which is around what latest DP/Thunderbolt/USB handles) would work fine. You can always add more lanes if you need anyways, at the expense of a thicker cable.
Yes, if Commodore wanted to compete, the Amiga chips needed to keep up with Moore's Law. Every 18 to 24 months, the processing and display power should double or more. In 1988, the Amiga 500 and 2000 should have had something like AGA.

The article correctly points out that 68k chips fell behind the x86 series. Yes, chunky pixels are useful, and the display hardware should support them. But if the game requires the CPU to draw each pixel one by one, the hardware has already failed. Instead, there should be some specialized processors that do the work. In fact, that's what happened in PCs. Doing all of the drawing with the CPU lasted only about five to seven years, then everyone had GPUs.
It is, in biochemistry region, it is typical to write protocol step by step during experiments. video can not ameliorate it more.
I found that it is useful to highlight direct quotes of cited sources, and there is plenty of them. here is CSS userstyle https://userstyles.world/style/14541/rt-com-quote-highlight
Fruit, nut and cork trees are all perfect examples of what you are looking for
I know you're joking, but I actually think complexity like that (when mostly unnecessary) is the least hackery thing in the world. Simple and effective gives me a hacker buzz
Thanks for taking the time to read the article! My responses are key’d by paragraph number.

1. The study is comparative in that it answers the question do engineers from other fields consider software engineering “real”. The interviewees answer more than whether they apply their an engineering design process, they comment on what they see in the industry from others, and resoundingly agree that software engineers are abundant and no different than “real” engineers.

2. We agree, aspects of the study could be improved. Nonetheless, I think Hillel’s analysis serves its purpose in leading the discussion forward on whether software engineering is “real” in a more productive direction than Jon Blow’s comments do, necessarily, as the topic of this HN thread.

3. Part 1 of Hillel’s article, linked above, addresses and agrees with your point directly. Suggesting that we don’t have a vocabulary vibrant enough to describe all aspects of the work people do with and on software yet.
Carbon negative seems like a misnomer, since all of the carbon that a tree absorbs literally becomes a part of its mass. Since mass is conserved (mass can't come from nowhere, and it can't be destroyed), how is it possible for the trees to store more carbon than what is required to produce them?
That explains a lot. It’s still a case of incompetence but this gives it a clearer explanation.
The utility isn't doing the work, they are hiring it out.

The reason it's denied is because more spending on infrastructure means higher rates. CPUC is trying to control rates.

For anyone interested you can read about the 2024 rate decision here: https://docs.cpuc.ca.gov/PublishedDocs/Published/G000/M520/K...

For example, PG&E wanted to replace gas service lines made "with Aldyl-A plastic that were installed before 1985" due to the risk of line failure.

The CPUCs decision was "PG&E’s request to replace unidentified services is denied. Moreover, the Commission does not find that PG&E has supported rounding up the number of services to be replaced by 73 per year."

It's a byzantine system of regulations that dive into the minutia of running a utility. Not to mention a lot of these decisions are by administrative judges since the regulations are written into law.
> Wake me when they upstream it.

Where is upstream?
I realised the Amiga had had its day when I played Dune 2 on the PC. It was a great game on the Amiga releasing to rave reviews. But the PC version on a 486 with a soundblaster absolutely sang. It made the Amiga look an entire generation behind. The Amiga version ran very slowly in realtime and in FPS, had a fraction of the digitised sounds, essentially no music, and for most people it involved swapping floppies to save your game. Experiencing the PC version made the Amiga version unplayable.

So I told my Amiga-loving friend at high school the the PC version was far better. He was deeply offended of course, but got his first PC less than a year later.
Between different algos or compared to other tools?
"catastrophic ADHD" is probably one of the best ways I've seen it described. At times I get hit with just how many things it's ruined over the years and it just makes me feel completely hopeless, like I don't even have any control over my life at all. I don't know if I ever will. It sucks feeling like I could be intelligent and have great potential but my ability to turn that potential into real action is so impaired that I'm almost completely useless and never achieve any of my actual goals.

I've tried to meditate before, but... it doesn't really work. If I try to think less, then thoughts will just hide themselves from me. repeatedly, some new fully-developed thought will just suddenly reveal itself to me, having already been developing for the past 10+ seconds without my knowledge. And this will just keep happening. Stuff just keeps happening in the background and I have no control of it. It's like other parts of my brain are thinking completely for themselves and all I can do is watch and beg for control, and never get it.

I'm autistic, and that type of experience is commonly recognized as an autistic pattern of thought.

I don't want to live like this, the catastrophic ADHD, but it doesn't seem like there's any way to fix it. I feel like my brain is completely defective.
I’ll definitely bookmark this for if I travel to Portugal!
You guys buy books? I only buy the ones I keep coming back to after I've read them through libgen
Colliding glass spheres emit triboluminescence
It’s the last collision of the day but the previous collisions are pretty entertaining too.
I think there are two reasons for these "inexplicable" pricing differences.

One is that different insurance companies specialize in different things. For example, if you want to offer the best rates to good drivers, you might actually want high-risk drivers to go somewhere else, or at least compartmentalize them so that your prime clients can still pay favorable rates. But if you do that, another company will show up and specialize in the customers you're walking away from. There's enough competition that no single firm can have it all, and there's definitely a lot of divide-and-conquer going on.

I also suspect that there's a multitude of ways to end up with a specific risk profile, so there's plenty of more or less random divergence on the tail end. Some insurers get where they want to be by giving discounts if you install a monitoring app. Others if you're in a "safe" profession. Etc.

> The math of insurance is based on having the biggest, most diverse risk pool to sop up any poor bets.

Sort of? Sometimes? There are diminishing returns, especially for car insurance where claim limits are fairly modest - I doubt it makes much of a difference if you have ten million versus a hundred million customers. A state-run monopoly has a comparatively weak incentive to make the math work, because it can always count on being propped up by the taxpayer - and if not, it can charge you more or offer worse service, and you can't do much about that.

Private monopolies share some of the same problems, so I wouldn't root for either. Thankfully, the car insurance market in the US is pretty competitive.
At one time I just gave up on using any config formats and instead went back to the good old simple "use the programming language as the config file too" approach.

It's certainly not cross language capable but when your editor knows exactly what's there and what's not with auto completion from the config file, that was a superior experience than caring about cross language issues that may not even be a problem depending on the project.

If you must, you can easily make an identical copy of the config in the build process to convert it to another language.
Two deal breaking issues:

1) The reason that the resolution is so high on the AVP is because it uses Micro-OLED which is also known as OLED on Silicon i.e. there is a layer of silicon behind the diodes which would block the light.

2) Transparent OLED TVs required a motorised screen to put a black panel behind the display. Only options are that or electrochromatic glass. Both of which are not black enough for watching movies etc.
Someone close to me has ALS and their only options seem to be in Mexico and China, not anywhere in the US.

From their research, it definitely seems like the FDA is the big bad not only in preventing treatments as a default, but also by disincentivizing companies from allowing dying people to trial unapproved treatments if their condition is far gone enough that there is a low chance of success. My understanding is that this is partially because people who take treatments and die (even if they were going to die no matter what, and did not die from the treatment itself) are used by the FDA against the biotech companies when seeking approval.
Apple switched to PowerPC a few years before the NeXT acquisition and Steve Jobs' return.