skysight-inc/HackerNews huggingface dataset:
Flipper Zero was designed in Russia, the company moved since the start of the war.
It’s not terribly hyperbolic. The headline is that they tamed the protein (MYC). That’s more or less true, they found a molecule that binds to and blocks MYC’s activity. Then in the article they (correctly) note that MYC is dysregulated in 75% of cancer cases. They don’t claim that that they cured or tamed 75% of cancer.

Finding a MYC binder is legitimately a big deal. It’s been known as a primary target for cancer for decades but there are zero drugs that block it. Now this shows the way towards drugging it. It’s a big advance for the field.
If Google and Facebook are doing it, then we need to start doing exactly the same! /s
Why not keep a permanent, separate branch for each version that is still maintained? And do trunk on each version branch.
When I had covid in very early 2020 I monitored my blood oxygen levels religiously as it declined precipitously and I became more and more ill. Given it was the first outbreak in seattle I was advised to stay away from the hospital unless it dropped to X, at which point they could provide palliative care as there was no treatment or available ventilators. I got very close to X, and did end up with an extended hospital stay and long covid. So - not how useful the blood ox monitor was but it did provide some form of comfort as I skirted with death to see how close I am.
Try https://infinitemac.org/

Pick a System Software/Mac OS version (you probably want something like 7.5), then choose the SimTower disc from the CD-ROMs drawer at the bottom of the screen.
It's a free platform to use and not a free platform to spam especially not if the only reason you posted this ask HN is to get people to go to your domain, that's simply ban evasion. It's a bit tiresome.

Yes, I don't like what you are building, but I don't care, I do care about you polluting HN.
I learned, quite by accident, that carrying around several boxes of the small Cadbury's Flake chocolate around a conference in Las Vegas was an amazing ice breaker to conversation. From there, the next game developer's conference, I dropped about $400 on custom printed sleeves for small Toblerone chocolate bars that I could give away. I've also always carried a different style of high quality business cards from everyone else, so that also became a conversation starter (about $150). I've also done a glossy magazine for my video game company showing off our achievements and projects for the past year (about $2,000). And a pop-up book of projects ($1,500). And a high-quality custom Rubik's cube (about $4 each). And a colouring book with branded crayons (about $1,200). Custom phone cases. Custom phone chargers. Custom USB cords. Custom tools for network admins. Ribbons for conference badges. High-quality tape measures. Custom branded private blend coffee beans. LEGO in our own custom branded box. Digital single-game "game & watch" style toys. So many different toys that endure. Toys seem to always go over well. All those tiny marketing promotions break the ice and have lead to several successful business deals.
They're USB cameras. I don't know the vendor, but I worked with 4 cameras wired back to a small Linux computer.
Do people still do badges as promotional items? My dad had a collection of button badges from long-defunct vendors that I found fascinating as a child. They're intrinsically longer-lasting than stickers, cheaper than t-shirts, and most people won't eat them.
Am I the only one just seeing a blank page? Proxying via archive.is did not help.

Edit: after some googling I found https://lists.freebsd.org/archives/freebsd-hackers/2024-Janu... but I couldn't read the whole thread at once
Extra ceiling fan remote was my favourite use.

Couldn’t find a ceiling fan remote one time ( I have 3 with the exact same remote ) and used it to manage fan speeds

Still doesn’t justify the cost but I guess it’s like my leatherman. Hardly use it but handy when I do.

I actually bought it when seeing the pwnagotchi comparison and expected functionality from the wifi/marauder dev boards to be included. Meaning I got my flipper in the first batch for my country but couldn’t get a dev board even months later
Wouldn't Stripe be significantly cheaper?

I'm making the opposite of a philosophical argument, I'm making a practical one. Apple is not going to take away the App Store, or make it too difficult for developers to upload apps, since that would be a real threat to their iPhone business.

Developers need Apple, but Apple needs developers too. Currently their market domination makes it an extremely hard collective action problem for developers. Not being on the App Store means losing out on the majority of your revenue, which makes it tough for enough developers to band together against Apple.
> They deleted every branch on merge

Wait, this doesn't sound like trunk-based development.

This sounds like a traditional branch-based workflow.

> to cut a release, took half a day to figure it out to make sure they didn't screw up.

Do you remember what was making the process complicated?

In trunk-based development, you ideally can tag a release wherever you're at. Your trunk is always stable and releasable.
If it's not, you fix it and then release.
> Animus between China and US is a recent thing, like post 2015.

Are people this dumb and ignorant? Animus between China and the US dates back centuries to the opium wars of the early 1800s. And animus between China and the US has been the norm ever since. Your comment was flat earther level stupid. Crack open a history before commenting.
“1200 seems too high for a phone, so I bought a raspberry Pi and attached a 4G module now I can make calls and browse the internet”…
Other than create the marketing buzz and pull together a community of hackers to make the on ramp to this type of programming easier.
This reminds me of when people claim they don’t understand why people get plastic surgery because it makes people look so bad.
I first mentally parsed this domain as "win driver" and thought it might be something providing some sort of compatibility with Windows
Thanks I will fix it
FLIR Chameleon3 connected via USB to a Intel Atom Linux SBC running ffmpeg to encode the video.

See EDLCAM in https://link.springer.com/article/10.1007/s11214-020-00765-9
What kind of error do you get? If you don't mind, could you send me an email at askutubeai@gmail.com?
What evidence have you considered to the contrary? Have you ever turned the chessboard around to look at this from the other side of the table?
Most people I've spoken to who have strong feelings about this topic have only ever looked at it from one side properly.

The GP is skeptical that one can go from A, a chance interaction between two systems, through a continuous uninterrupted, robust, repeatable chain of unguided interactions, and arrive at Z, the placenta. An organ whose function and elegance is unrivalled by anything we as a species have made with logic and thought.
And why should he not be skeptical, everything we've practically achieved in terms of technological progress has been the product of mind and intelligence, any claims to be able to do the same thing without that should be scrutinised very closely.
I assume the Home Assistant integration is through the Enphase cloud account. Herein lies the peril.
My friends who watch/ed anime all have kids whereas the two or three who never really got into it are willfully abstaining from parenthood. My anecdotal experience trumps your bland joke.
Most smartwatches estimate VO2Max using other data (mainly how fast you run/ride, your HR, and your weight). Blood oxygen level is not used for that.
Is this still being used?
I remember having to license montavista during days of TI gateway chips.
Life extension is just too big of a deal, and when people revolt it can get really messy. The "rich and powerful" are fully aware of this reality.
and let me guess... no price drop
Iirc Google said they'd start penalizing non https sites in search results and browser makers added much more aggressive warnings to http pages.

It caused quite a commotion among small site operators.
> “…tested the model on a part of our sample that it was not trained on and found that it achieves a 98% accuracy rate in replicating the human classifications. Armed with our highly accurate LLM…”

So concerned with checking the box of incorporating AI into their work, the writer managed to quickly associate AI’s classification with “must be right”.
Yep, LEGO endures. I've done entire branded boxes filled with a custom instruction booklet, such as "build this diorama of our video game studio" or "this is a character from our upcoming game" or "it's a LEGO GameBoy with our game on the screen." And it has to be LEGO. Anything else is considered cheap and reflects on your company.
The article lack substance, it doesn't offer a substantive critique and the cherry picked examples are both confusing and arbitrary. I say this as someone deeply critical of the way deep learning models are being trained and deployed, and deeply fearful of how they'll distort our culture in the future. But we need substantive engagement with the aesthetic and economic issues. Such a shallow critique has no place on hackernews.
Not to mention making an already gut-wrenching decision (to place your own child into the foster system) even more difficult if it's perceived to be a one-way door.
HN posts have generated 0 paying clients for AIMD. If you think that I am spending my time posting on HN for the sole purpose of advertising AIMD, then you don't have a knack for advertising. HN is just not my target audience.

Meanwhile, the comments have been a valuable source of feedback that highlighted several flaws in the product.
Thanks a TON! A few dollars a shirt is wonderful since I already know I love these, and I actually prefer unprinted.
Political comment aside, I think everyone's talking about it because it seems like the only source of change in the current day comes from courts making decisions and changing to how existing laws are interpreted. Congress hasn't made any real meaningful new regulations to curtail anti-consumer behavior since the 08 crisis. People were hoping things would change from this lawsuit, but SCOTUS didn't want to hear it and set precedent for whatever reason. Nonetheless, people continuing to talk about it will certainly keep it in the public consciousness and might lead to eventual congressional action ( /s ).
> Why is that a problem?

Because that has the risk to move the world away from open source and more towards closed source.
> “1200 seems too high for a phone, so I bought a raspberry Pi and attached a 4G module now I can make calls and browse the internet”…

That actually sounds really cool...
I love this thing but I mostly just use it to avoid touching hotel TV remotes.
So would this become a prophylactic drug or a treatment once someone has cancer?
I also have the free will to choose Ozempic.
Based on hearing of Apple’s price gouging behavior for their App Store, especially their poopy-baby response to losing IAP rules in the Epic lawsuit, I would be pleased if he won.

Additionally this might be a good opportunity to donate to a F Apple campaign by donating to this guys legal battle. Just to send the message.
> I'm open to that, but what is the plan for forcing organizations that are doing the wrong thing to do the right thing?

i'd say figure out how bad what they did is. Not hashing and building sql strings like that: go to jail for a long time.

Gross carelessness with private data: go to jail for a very long time.

About the same time as if you purposely published the data, or purposely dropped a table, because thats about what you did. If you dont have the competence, you have no business writing such a system. If you dont know how to calculate a bridge that wont collapse, or dont know how to follow the plans and build it properly, you have no business being there.
You're simply wrong. And every court and government around the world agrees.

Companies have a right to charge a fee for using their platform.

Apple can not be forced to give you their SDKs, Services etc for free and help you sell that product on their marketplace for free. They have a right to charge something. You can rightfully argue that the 27% is way too high and courts have agreed. But those like Epic hypocritically arguing for 0% no one agrees with.
> What is interesting is that since 2022 a lot of sites and host services decided to ban access from Russia.

Same from Brazil though probably way less. I blame Cloudflare, overzealous sysadmins and paranoid Wordpress security plugins.
In real world, as a developer you can't control what IT uses for WAF, so you may have to work around it as much as you can.

At a previous job the IT set up a spam filter which used a keyword list (dumb attempt anyway), but it also searched the email headers (not only the body). As a result, we weren't able to receive email if one of the SMTP hops was named, say, smtp.essex.company.com.
I see what you did...

>FATHER: Listen, lad. I built this kingdom up from nothing. When I started here, all there was was swamp. Other kings said I was daft to build a castle on a swamp, but I built it all the same, just to show 'em. It sank into the swamp. So, I built a second one. That sank into the swamp. So, I built a third one. That burned down, fell over, then sank into the swamp, but the fourth one... stayed up! And that's what you're gonna get, lad: the strongest castle in these islands.
I don't like long lived branches. For me a branch is work in progress. Work should be finished, once finished the branch should be deleted. If you start work again, create a new branch.

But sure, if supporting an older release is some kind of ongoing trunk-based process this is also a viable solution.
For me a big part of it is how gestures track, the curves used by animations, inertia, bounciness, etc. Under iOS it all feels refined and naturalistic, whereas Android’s counterparts land somewhere in the uncanny valley and come off as more mechanical (fitting given its name, I suppose).

Aside from that, in general you can feel more “seams” between components and rough edges all throughout Android’s UX. It reminds me of how the Linux desktop experience used to be several years ago actually, except Android seems to have gotten stuck for unknown reasons where Linux DEs have continually improved.
That exactly proves my point, if Bangladeshi can do it, the US could too, if it was a priority. It is not and it probably won't ever be.
reminds me a bit of klogg https://github.com/variar/klogg which is more for log files and based off glogg which went dead. it has nice filtering and highlighting type stuff. It's great for live views of log files.
Fun story: thanks to Xsan you can buy Thunderbolt SAN devices from various vendors. Now, the Areca ARC-8050T3 SAN with its 9 Thunderbolt inputs has become insanely popular on movie / commercial sets. Drop it into a 4U rolling case and it becomes the motherlode where everyone, no less than nine people at the same time can just plug a Macbook in without any problems, configuration, maintenance or anything. Just works. It pushed Areca to make optical TB3 cables, in fact, now people don't need to stay so close to the motherlode.
1-3% of payments does not run an app store for a billion users.
> What they take has been proven to be far greater value than what they gave. It isn't a fair "trade", at all.

Sure it is. As long as it wasn't coerced.

> To be fair to China, corrupt locals allowed it to happen.

I have a feeling that any trade with china or anything that helps poor countries progress is 'corrupt' to you. But then again, you push so much ant-china shilling, I recognize you just from your username.

If china is taking so much for so little, why isn't europe or the US swooping in and offering a better deal? Perhpas because china is giving them the best deal?
Tietoevry ransomware attack causes outages for Swedish firms, cities
The goal of the Rule of Law is to reduce this problem, but it hasn't succeeded at eliminating it (and never will). It's exceptionally hard to design a society so that someone with more resources doesn't have an advantage over someone with fewer resources, without massive restrictions on freedom.
A month after I met my now-wife, I went with her to
Thanksgiving at her sister's house. My nephew was two at the time, and he had three magnets: a horse, a frog, and a duck. Each of which made the respective noise when you pushed a button on the magnet.

Naturally, being who I am, I took it upon myself to swap the circuit boards around among the magnets. Apparently this caused some distress a couple days later when my nephew discovered that the frog now made horse noises.

We did not give our wedding guests the opportunity to object to our union.

TL;DR: it sounds like you have an opportunity on your hands!
I don't think there's a coherent point here. Jury nullification can occur in most common law jurisdictions (i.e.: legal systems that descend from the British legal system). There's no specific limit (say civil versus criminal) on when it can occur. And it absolutely could apply in a copyright case - that happened to come before a jury. It specifically does not depend on the validity of a legal defence, but despite it.

On a different but related note It's worth remembering that the reason piracy is enforced with legal payment demands in Germany and Japan, but not the US, UK or most of continental Europe, is that civil disobedience made such legal demands ineffective in most territories.
Likely neither. Myc and p53 are these mythical whales that people have been trying to tame for many decades and nothing has happened. Nothing likely ever will. This would probably be the ten thousandth medium impact paper on myc in history to give some context and I’m not exaggerating.
Who cares what Epic wants? Their incentives align with mine so I supported them. Apples practices here clearly harm consumers by reducing competition on iOS. It is obvious to me that if Epic won iOS would be a better product, at least for me.
The nasty bit you speak of is split brain, and it's addressed by C. C says that if you read you always get the last thing written. If the nodes can't communicate and someone does a write then the other half can't return what was written, so CAP is broken.
> On the other hand, doing this is absolutely alienating every developer.

How did so many devs show up if the platform fees are alienating them ?
I think Google's situation is due to its promotion culture. As Hasting of Netflix said, culture is all about who gets rewarded and who punished. When so many people got promoted for so-called impact and complexity yet their project ultimately failed, many employees' mentality simply changed to chase short-term personal gain instead of what's right for the company.
I think their point is more that the usable scale of teams/codebases is not limited by trunk based development. Which that is pretty ample evidence of.
My apartment uses Latch deadlocks. From what I've read the model _should_ support an NFC key, which of course we don't get. I'd love to figure out if I could do it myself. Ideally I'd be able to use my iPhone that way automatically though (the app on iOS apparently can't due to Apple rules but I'm not an expert). When my hands are full with groceries or whatever it can be a chore to pull out my phone, dig for the app, and get it to unlock the door.
I think first programming languages need to fit with what the person's motivation is. If they want to do statistics, data analysis and the like then surely Python, R and the like will be a good starting point instead of Bash Shell. Also, the teacher having a very good command of said language as well as all the tools for the environment they'll be using (*nix container, Windows, Mac, etc.) makes a big difference. Things like setting up VS Code to debug something is a daunting task for a beginner with no idea on how to set it up (if they devote themselves to setting it up). Language choice isn't that big of a deal but getting a teacher who knows how to guide the student and teach them everything in said language is (the article shows how the author having a good command of D and knowing said tools taught effectively while he struggled with JS and Lua).
I will agree that that particular part of the write up is suspect, who exactly said this beyond those nameless “business leaders” that are just now realizing remote work is a thing? I wouldn’t argue that frontline workers haven’t harbored some resentment to remote coworkers as remote work got more widespread, the framing of it being a new thing seems disingenuous.

The overall takeaway I got is that the better approach is to bring better value to the frontline workers to make up for the discrepancies in “fairness” - honestly, this should have been the thinking from the on-set.

> The need for people to go back to the office is not driven by some sudden compassionate drive to equalise workplace differences. It's driven by an entire class of asset for the very wealthy becoming almost worthless.

I didn’t see anything suggesting this as a remedy in TFA, though I’ll go read it again in a bit. Completely agree that the only reasonable defense of any push to end work from home is to make up for real estate investment
>They're still working on how to effectively get it where it needs to go in the body.

I skimmed the paper, and this is
indeed the case. The full extent of their testing was in vitro testing against the lysate of a specific cancer cell line -- that is, against the "raw contents" of a bunch of cancer cells which have had their cell membranes removed.

In my lay understanding, getting their stuff where it needs to go -- and only there -- is likely to be very difficult.
96% of servers run on the Linux kernel - your banks, your military, your tech companies. With leaked secrets comes power. I'd rather it not siphon to the CCP. Not a fan of them. I know it's trendy to criticize America, and some of it's valid, but I'd prefer it over the CCP.
Spitballin': I imagine that chaos in the parents' own lives is a major factor. The nature of labor in the US makes employment, for certain classes of workers, highly unstable. The nature of housing markets and law makes housing, for certain classes of workers, highly unstable. The nature of health care (including addiction care) increases vulnerability in mental and physical health. The nature of transportation infrastructure and services make many aspects of life unnecessarily precarious. On and on.

"The measure of a society is how it treats its weakest members," isn't a platitude, it's a wake-up call, to pay attention to how bad things can get. If you're going to lose the health insurance that covers your asthmatic kid, because you're about to lose your job, because you can't afford to fix your (planned obsolescent) broken-down car, because you spent your fix fund on rent that increased 20% year-over-year... well, then, it's going to be difficult to be a good parent.

I fully expect the "personal responsibility" people to go in on me.
Definitely a treatment. MYC is only a problem once cancer finds a way to generate too much MYC protein. Only them is it necessary for a drug to knock it back down
You can sync up on rolling codes with the flipper without too much effort. When there are a few private keys involved it gets more difficult.
You have a right to compete in a fair market, in the us at least. Apple has a monopoly on app delivery to everyone who has an iPhone, clearly their practices are anti competitive. It does not matter that judges disagree, all that means is that the current laws are deficient.
It might be a matter of cell count still, elephants have many extra copies of p53, one of the main cancer-suppressant genes. We have one copy, elephants have 20. So the linear correlation may still be there if you'd remove those extra copies.

https://news.cancerresearchuk.org/2023/08/12/can-elephants-g....
Which of those three tools works best on GitHub? Ideally without paying (not that I mind paying but it’s impossible to get the approval for some niche tool like this)
I Feel Love for Others (2019)