skysight-inc/HackerNews huggingface dataset:
When I decided to have my genome sequenced, I went with Illumina's Understand Your Genome. This was a project they had to basically get rich execs to have their genome sequenced, learn their risks, and then invest in VCs investing in genomic startups (although it was just marketed as a product, Illumina had a larger goal).

I had my blood taken and a whole genome sequence- a 50GB file of reads off the machine, along with variant call files that should show how I differ from the reference genome, and another variant file that called out risky variants.
You can download the files (https://my.pgp-hms.org/profile/hu80855C).

When you did UYG you'd go to this fancy spa in La Jolla and they give you an iPad with the files and you also talk to some genetic counselors.

I made a number of interesting observations when talking ot the counselors. The first is that they said they were confused by my report because it said I had absolutely no known risk variants (apoe, bcl, etc) and they had never seen that before. They also said, when they see some rare v ariants that they would just google for the variant and read random papers. What they said convinced me that genetic counselors, and genome tests in general, have limited applicability- there are a few genes where variants are clearly associated with negative disease outcomes, and the tests for those are very valuable (This is especially true for cancer, but other diseases as well) because they are clinically actionable.

But it also showed to me that counselors are making up garbage, because scanning the raw literature for variants and assuming that because a person has that variant they will be at risk, is not a good assumption. In my mind, the variations on polygenic risks scores have convinced me that we need to build large-scale (whole-genome) models of disease that use nonlinear functions trained on extremely large-scale datasets (like UKBB) to build up wholistic predictive models that do a better job of encapsulating the complexity of biology and its relation to disease, to the point where we can actually start making useful treatments and cures for a wide-range of genetically determined diseases.
Corollary: there are 0000 0010 types of programmers — those who have never had to use an oscope for debugging, and those who have.
Well the ironic part is that their SNP array now would be fairly effective because genome imputation using 1k genomes etc has gotten so good. But now WGS is cheap enough that the value prop of using imputation is getting more and more marginal.
Is there anywhere to get a DNA test anonymously? I assume maybe you could put false information into 23andMe, but I assume they'd still have your name from your credit card.
Depends on the hardware manufacturer. From what I know, developers at Intel are treated pretty well. It all depends on how integral the software component is to the overall product's market success. In the case of Intel, a GPU with poor and buggy drivers is not gonna sell, so software is pretty important.
I never said that you should prefer 3 star restaurant. I was responding to the specific claim that home cooked meals are always better than eating out.
But then you also have to meter the gas to know how much to pay. Most gas stations have no plan for a power outage, and little incentive to plan for such a situation.
I agree with you on acceleration. But motion blur in a terminal sounds like something straight from hell.
Tabliss – A New Tab Page for Chrome, Firefox and Edge
I don't disagree that those are potential cons, but it also highlights how much versatility you can have with a fountain pen. For instance, there are ones that travel very well with shutoff valves to prevent ink leakage. There are options for filling that can all but eliminate getting ink on your hands. Nibs can be tuned and ink choices can align with what paper you write on, so you don't absolutely have to change the notebooks you use.

You highlighting the language issue is interesting because it makes the assumption that one can get the line width they'd like from a ballpoint pen, which personally, I didn't. Ultimately you need to choose what works best for you, and the language you write in is certainly a consideration. I'd much rather have the option, than be stuck with "one size fits all" of most ballpoints. So saying that's a con is a misnomer for me.

All that being said, a fountain pen is not a tool for every use case. I was a lot happier when I realized that a ballpoint or rollerball is far better suited for tossing in a bag or having at the ready when traveling.
Lower Obesity Rate During Residence at High Altitude Among a Military Population
Can Sampling Survive in the Age of AI?
I've been a software engineer for around 15 years. I've got good experience working both perm and as contractor, both in the public and private sector.

I think because I have quite broad appeal in my experience I tend to find it reasonably easy to get interviews, and I've always felt I have an above average hit rate of getting the jobs I apply for when I get interviews.

Early last year I lost my job and it was scary how quiet the market was. I managed to find a job in the end (I think I got quite lucky to be honest) but it was a contract role so recently I've been looking around again as I will be out of work fairly soon.

I've sent my CV out for ~30 positions over the last couple of months and I've heard absolutely nothing back. Well, one recruiter said I had been shortlisted weeks ago, but then I heard nothing back.

I'm actually stunned at how bad the market is right now. I've had two previous colleagues contact me this week alone asking if I know of any work going because they've been out of a job for a while.

But not only is the market bad right now, I'm also noticing that rates for many engineering roles have tanked. A recruiter reached out about a React developer role recently which had an advertised day rate of £200 ($250), for comparison in 2021 your average React developer day rate might be around £500-600. So even where people are finding roles in many cases they're taking significant cuts in pay. Lead developer and very niche roles seem to be holding in a little better, but from what I've seen they've still come down quite a bit in recent months.

Additionally because so many talented people are out of work right now even if you find a job at a significant pay cut you're going to struggle to get it because in some cases these roles are getting 50-100 applicants – many of whom have many years of experience.

What worries me is that some people I'm talking to still seem to think that it's not that bad out there, saying things like, "I've always found something", or "there's always someone hiring", but I'm telling you this time is different. I know multiple people struggling to pay rent and feed their families right now. Tech did reasonable well during the GFC, but right now it's dire out there for tech jobs. Anyone reading this needs to be prepared to lose their job and be out of work for at least a year, and even if you find a job you need to be prepared to take a significant pay cut. If you can't afford to be out of work for a year you need to save and prepare – especially if you have a family dependant on your income.

I'm based in the UK, so perhaps it's better elsewhere in the world, but I have never seen the market this bad before – not even close. I wouldn't bet on a rebound any time soon either. Work from home, higher interest rates, large numbers of new tech talent graduating, and increasing automation in software development workflows may keep the market cool for a long time.
There is no lack of fumes. They are somewhere else, that's all.
Google definitely can't just block third-party cookies on their own:

https://blog.google/products/chrome/privacy-sandbox-tracking...

On January 4, we'll begin testing Tracking Protection, a new feature that limits cross-site tracking by restricting website access to third-party cookies by default. We'll roll this out to 1% of Chrome users globally, a key milestone in our Privacy Sandbox initiative to phase out third-party cookies for everyone in the second half of 2024, subject to addressing any remaining competition concerns from the UK’s Competition and Markets Authority.

https://assets.publishing.service.gov.uk/media/653a58e2e6c96...

We would like to reassure the ecosystem that deprecation of third-party cookies can only take place once the competition concerns, identified by the CMA during its investigation, are addressed by Google. We have asked Google to be clear about this in its communications. Under the Commitments, there will be a Standstill Period of 60 days that applies before third-party cookies can be removed. This period can be extended to 120 days. During the Standstill Period, we will determine whether third-party cookie deprecation can go ahead based on the evidence we are gathering. This includes evidence from tests of the tools conducted by Google and other market participants. Our aim is to gather evidence of the likely impacts of the changes by the middle of 2024. The Standstill Period will take place following this, and once testing has been completed.
Well, I suppose it's nice we now have a canonical example of how not to do messaging around a successful credential stuffing attack...
Ornaments are symbols that encode values. I was surprised they didn't include Venturi's "ducks vs. decorated sheds," assessment of ornamentation. (https://99percentinvisible.org/article/lessons-sin-city-arch...)

The idea is that an unornamented building is just a single (arguably vulgar) symbol intended to represent something else. The example is a building shaped like a rubber duck. A decorated shed is a building with a purpose and then ornamented symbols attached to it to integrate it into its environment.
Redirecting Subdomains to URLs
> The US isn’t even trying to manage any money from its resources in a way that benefits its citizens in the long term

Different goals. Gas is and has always been (afaik) cheaper for American citizens than for Norwegians. Having more money in your pocket is a long term benefit for Americans.
Is that of the same genus as the Sarlacc?
The states don't need to map 1:1 with cities or temperatures. They merely need to encode all information collected so far which is still relevant. They also don't need to represent all possible situations - anything that is super rare (eg. temperature of 95C) can simply be diverted to a special "invalid" state which triggers regular code to take over for those few entries.
Qualcomm's new XR chip sets up Android-based Apple Vision Pro competitors
Rain in the face has honestly never bothered me. Somewhere between -5 and -10 degrees C I replace my bicycle helmet with a ski helmet and ski goggles. Somewhere there I also start wearing a baklava.
More likely this will prove to be another example of individuals under appreciating their personal data and privacy, and over appreciated some kind of novel technology.
it makes me so glad to hear that, because my first reaction (well over a decade ago) to people using arrays and imputation is: they data is there, why are you estimating it probabilistically (realistically, at the time, whole genomes cost too much, and scientists iwll always do short term probabilistic estimation to get an approximate answer quickly.
Taking just shipbuilding as an example, the US is way behind China in industrial capacity

https://www.businessinsider.com/us-navy-chinas-shipbuilding-...

The Navy is struggling to staff the ships it does have

https://www.forbes.com/sites/craighooper/2023/12/12/facing-a...

Recent acquisitions like the LCS are expensive boondoggles (the Navy managed to buy a boat that dissolves in water) and are getting retired years before their planned service life.

I’m not sure where this confidence comes from?
Yep, I remember seeing a variant with 2x Cat5e, 2x coax, and fiber. Iirc the argument against them was that they were a pain to install in typical residential framed construction because the bend radius in reality was like 3 feet (probably exaggerated, but not by much).

Having now done retrofit Ethernet install in a 75 year old house, if I ever build a new house it's going to have low voltage conduit from attic or basement to every interior wall and one or more big conduits from attic to a single home run location, itself with a dedicated 20A circuit.
> Slow charging is also better for the battery.

My understanding is that this is largely a myth, at least with modern BEVs with intercooled battery packs. My understanding is that modern battery packs can Level 2 charge with no additional degradation, because they don't get any hotter than during a Level 1 charge.

Level 3 charging is different, but even then, the degradation in battery life isn't as much as you think -- I've heard numbers as low as just 3% faster degradation.
Digging into the Orange España Hack
Those restaurants have process. It's called prep or set up or mise en place or whatever. But there's process.
Alerted by a friend who noticed his profile had changed, I checked mine. Going from having no French ancestry when first processed 5 years or so ago, I now have 12% French ancestry. That's a huge deal for me, because one of my parents was adopted. Hugely unimpressed at the lack of transparency (pro-active notification anyone?) and the overall accuracy - I don't trust these results anymore than the original, but the original did cause genuine distress.
It was in the hundreds of employees, but upper management liked to run it as if it was in the thousands. I don't know which of those answers is more meaningful as an answer to your question.

Either way, HR was completely on board right up until I had a good candidate! They were actually very helpful to begin with, assisting me in summarising information about the company, sorting out potential legal issues ahead of time, finding places to publish job ads, etc.
No, not really. I've never heard it used in that specific context (meaning excluding "lower" things) without larger explanation that someone is talking about strong AI or AGI or similar. You can define it like that if you want but you'd be railing against decades of academia and now both users and marketing, and deliberately using terms you expect readers to misunderstand.

AI is a broad field covering far simpler techniques like SVMs even if they're not deemed to be as a way to achieve AI.

Rain is water, even if water covers more than rain. Serverless functions still run on servers.
That is nice. I already use pion for video call in browser. That's an interesting add'on.
It's all about branding. They got in early and really got their name out there. Everyone has heard of 23 And Me. Off the top of my head, I can't think of another brand (though I know they exist), and people I know IRL still refer to 23 And Me.
> In a way, doesn't it already "talk to itself" when generating sentences, e.g., its output token gets added to the input tokens successively?

If this is the basis of a mirror test, most AI recognition attempts have pretty high failure rates, so I'd say they currently fail. But if we presented a similar test to a human, "did you write this?" it seems to fall short of a mirror test because it can be falsified by an otherwise unintelligent algorithm which remembers its previous output.
The blue zone stuff has been debunked. It’s caused by poor birth records and pension fraud.

> In the United States supercentenarian status is predicted by the absence of vital registration. In the UK, Italy, Japan, and France remarkable longevity is instead predicted by regional poverty, old-age poverty, material deprivation, low incomes, high crime rates, a remote region of birth, worse health, and fewer 90+ year old people. In addition, supercentenarian birthdates are concentrated on the first of the month and days divisible by five

https://www.biorxiv.org/content/10.1101/704080v2.abstract
Interestingly, I just got a sketchy-looking job lead from a posting I made on this month's "Who wants to be hired?" thread.

I'm being very cautious, and I'll be curious to see how this plays out.
Im not recommending doing this, but you may want to allocate an address to use as a magic number.

NULL is a magic number address that is guaranteed never to be a valid allocation. By allocating an address, you can creat your own magic number, that wont ever be used by any other allocation so you can give it special meaning in your code.
This is another get out or pay moment. The question is how will this work for bitcoin users. Crime happens with any form of payment; the issue is combined effort (and lack of) on all sides. Average crypto liquidity is also to low for a slice. If these documents were to be managed and reported by all exchanges and "automatically signed" the "security" of users isn't an issue directly only bad actors. This information is already required upon sign-up on exchanges. What are we doing?
> Big corporations are absolutely terrified of accidentally using health data illegally

I am acutely aware of this, and am also aware that most "big corporations" have nothing to gain from mishandling/abusing PHI. But health insurance firms obviously do.

Another notable analog is the credit reporting industry. Despite serious & repeated abuses of consumer financial privacy, these companies consistently get off with a slap on the wrist. And we're supposed to believe that their neighbors, the insurance industry, are good guys from a radically different paradigm?
I'd love it if it has an api, and maybe with watermark and limitations (xx generated images per month) -- but I also understand that will severely limit the revenue for it
Steve Mould (himself a good science educator on YouTube) said that Technology Connections makes videos about things you didn't know you wanted to watch until you watched them.
This worm = 3 x 10^1 cm

The order of magnitude longer worm = 3 x 10^2 cm

Here it is: https://en.wikipedia.org/wiki/Eunice_aphroditois#Description
> If people reused passwords for 23andMe, is this really 23andMe's fault?

Yes absolutely. If it were one account being compromised due to the user reusing a password, that would be the user's fault. But what happened is credential stuffing, and that is absolutely something a professional IT organization should be prepared to defend against.
I know, but the fact that people can’t even tolerate the inconvenience of an EV gives little hope for public transport, car sharing, bicycles etc.
What I didn't see in this (and the couple others I've seen mentioned) is talking with more than one character in a scene, or having multiple scenes with the characters in different positions/poses/clothing.

My particular story has a number of folks with various handicaps (magical realism with a COA vibe), and trying to get an AI to do a reasonable character in a wheelchair is hard but doable, while amputees or folks with hearing aids is nigh on impossible.

To be fair that's probably more a "me" problem than a "you" problem...
This is how you can implement same service while preserving privacy:

1. Customer goes to nearest pharmacy and buys sterile vial and swab.

2. Customer takes sample, writes 30 random numbers on the vial and sends it via mail.

3. Once a month one giant zip file appears on service's website with random numbers and corresponding diagnoses. Customer downloads it and find their random number and corresponding diagnoses.
I didn't even have EVs in mind specifically. I'm just fairly sure most new cars are safer than most 17 year old cars.
I’m on the 3rd floor. They come from the walls. There’s nowhere to place a sacrifice.
Fair enough. I'll add the bit that they're fine if you don't need the ink to be anything more than short term. Excited to hear how the experiment goes!
> But why did the team need to grow to that size if they were highly effective before that?

Because that team got stuck with all the work.
There's a separate discussion about that here: https://news.ycombinator.com/item?id=38861271

But shortly, customers are told that the product will be shut down in 3 months, and they will be reached out. This probably means that they will need to find another solution.

As for investors, this depends on the cap table and termsheets.
A TL;DR of LLMLingua
Garmin showing different user's profile information
$500 will get you a Pro-line KitchenAid mixer. These are all stainless steel and can mix seriously thick dough. They'll also last a very long time.
I can't believe that was ten years ago. I remember it happening, here on HN.

Edit: 11 years. Give me a break, it's only Jan 4
Better yet, is it at all feasible to do at home for a Hacker News type with the right equipment and not breaking the bank?
Human-Powered Helicopter
Every other healthcare website I use requires me to use enter a code texted or emailed to me the first time I log in from a new computer. If someone used a corporate email address for personal services, they're likely used to being locked out of things.

23andme is also unique in their ability to create security questions to authenticate users who get locked out. "What is your date of birth and can you form a sideways U shape with your tongue?"
On the other hand, my dad signed up for 23&Me and one day got a ping.. and then a few more... and a few. more. It turns out he had made a "donation" years earlier and apparently the donation was used to make a bunch of IVF which were then born. It was kind of amazing to learn that I had a bunch of half-sisters and brothers around the US.

IBD is pretty reliable and it tends to get better over time (hence the late-arriving signal of french ancestry). I don't understand the "lack of transparency" and the accuracy comment you made: they didn't have the knowledge before, so presumably they reported "european" rather than a wrong country?
I disagree that jquery adopted anything from perl. jQuery's $ is not a sigil.
While I really admire this, I can't help but think we live in an entirely different era.

How do you deal with content moderation?

The spammers/native advertisers
generating useless content to make a few pennies?
The End of Town
Yes, but he shouldn't have personally been involved enough to know who was staying there and when. There should have been a firewall.

Instead, Trump routinely steered the US govt and its guests to Trump businesses, and they were "coincidentally" charged extremely high rates -- essentially a bribe.
In the U.S., I think employers are required to ask specific questions about ethnicity, gender identity, veteran status, disabilities, and if you're authorized to work in the U.S.

Except for that last question, I think they're required to let your answer be "I prefer not to answer".
Or who swiped them off my porch in the Lower 9 in my case.
Hey adonese! I'm definitely planning on exposing an API in the next few weeks - it has been requested quite a few times.
While there are people that do this, I do not think that Whitney is one of them. This code is not obfuscated; it uses macros and strategically defined functions to allow writing code in a style similar to APL that appears natural (-ish?) to someone fluent in that programming style.
Hmm, that’s interesting. Thanks for the correction
Is The Vessel still closed because too many people were committing sudoku by jumping off it?
> In my case, I might've been lucky, though. One of the co-founders had a CS degree and deeply valued the productivity boost we got from custom software.

This. A mentor told me, “[As a software developer], never work for a company with a CEO who has never pushed code to production.”

I think you miss some good places to work by following that advice, but you avoid a ton that are worth avoiding.
New Yorkers feel betrayed as police radio dispatches end