skysight-inc/HackerNews huggingface dataset:
Choose a random compound X, feed it to rats and see what happens. Could somebody explain how does one choose X?
If Abbott wants to sell different doses of the same pill, I don't see how that could be prevented. But either the doctor or pharmacist should say, "Hey, this is the same drug, just at a slightly different dose, and actually no studies have shown that the new expensive one is better... so just use the cheap generic."
Well, their product has been unjustly removed from both Google and Apple stores. I'm surprised the blog post isn't filled with more negativity towards both companies - the "sensationalist" title suits the content and tone perfectly.
Let's rewrite this: I work with entrepreneurs and have a pretty good window into their world. What I am seeing is too many poorly-skilled young people lacking business acumen and trying their hand at starting their own business, when their time could be much better spent on other pursuits such as learning to code.

I work with developers and have a pretty good window into their world. What I am seeing is too many poorly-skilled young people lacking developer acumen and trying their hand at writing their own code, when their time could be much better spent on other pursuits such as learning a business.

See, it's just as valid either way, in other words it's not specific to entrepreneurship at all. You learn something--whether it's coding or running a business or playing a sport or anything else--by trying and failing, evaluating, and trying again.
I believe the Lean Startup defines disruptive as anything that fundamentally changes user behavior. Like adding 6 blades and an aloe strip to a disposable shaver is additive, but pushing a straight razor is disruptive. Not great examples but maybe you get the idea.
I dont know much about this Tupac dude other than that he was famous and died, and then yesterday a hologram was represented of him somewhat convincingly at a public performance on a stage. It makes me reflect that, of my superset of all friends, 99% of them I have not talked to in years, and they could very well be dead. A few actually are and I found out only recently. To suppose there eventually will be a way of programming the states of our personality into some agent, and let others interact with it, I might say this surrogate might be enough to trick my brain that they are still alive. What if facebook could ask you 1500 questions, and emulate the first 80% of your psyche? It would be a weird way to remember someone, chatting with their agent like that. Like that mastergeek at the end of Serenity, perhaps. Some limited interaction thing. It's all damned weird to think about. I am uncomfortable with this thought experiment so far.
Clojure also targets JavaScript via ClojureScript. So you could write Node.js apps with ClojureScript as well.
Yep, that's it! Thanks! And takes a lot foil hatiness out of my intial post. :-)
My point was a bit different. The day of the deads is a day in which you remember the deceased as a whole. It's not the same, to me, as remembering that particular person, together with all your common friends, in a celebrative way (i.e. "Happy Birthday").
--@puntofisso
There's a technological solution to situations like these: make a full screen, offline capable, mobile web app.

Discovery and charging for your mobile web app or for content within it may be challenging for the foreseeable future, but hopefully not forever.

Another issue is feature parity with native SDKs, which seems to be very slowly narrowing each year.

Ability to produce performant apps is another area with very slow but greater than zero progression.

For games, sure, go native and take advantage of the store discovery and payment platforms, access to all the APIs, and performance.

For other kinds of apps like these, maybe mobile web apps are a better idea.

Edit: clarification.
It's essentially a bookmark service, right? This concept is extremely well suited for running on a personal server. I'm not sure there'd be widespread interest in such a thing, however.
Renew SSL Certificates
Most likely "anyway that is able to obtain grant money."
Electrical Generators and Excitation Systems: Selection,
I'd file this under "don't hate the player, hate the game". Abbott can argue that they're maximising shareholder value, as they are legally obligated to do. The rules that make patent trolling and the like profitable, though -- that's what needs rallied against.

Well, that or change the legal definition of "corporation" to include a "don't be dicks" clause. And that's just not practical.

PS: I don't really like your title - it's pretty editorialised, and doesn't actually tell me anything about the article.
From Exquisine to Crouton Labs: Where are they now?
Ha, strange to see a friend in that article.

Also, the Tony mentioned went on to do the iPod and the Nest.
StackOverflow and StackExchange. I consider HN a social network for hackers too.
Express is pretty great, very bare-bones though.
Python doesn’t play nicely with others
Show HN: CryptPage, experiment in online publishing using client side encryption
So the only reason it's not a problem is that it doesn't work?

"Your Honor, yes, I shot at him, but I missed!"
It isn't an apology in that sense of the word either. There is no defense here. Just a not so technical explanation.

Though, the article promises a defense in a later post, so perhaps it will turn into an apology then.
Firstly, Congrats. Around half a million users in three months is a great achievement.

But as for 'now what?': I noticed that there is nothing in your list that I would state as being a direct win/win. Almost every item on your list seems like a distraction (yes, a distraction that will get you the really important money).

The exception is your suggestion of 'premium features'. But, if not done correctly, you start competing with yourself - and your free users might start to resent you. Instead, what if you focused on one or more features that are:

(a) free but bring you revenue - like helping users sell albums (and taking a small cut).

(b) require payment because of some limitations - like showcasing a users profile for a day.
When will smartphones reach saturation in the US? They're already at 50%.
It is true that many commercial satellite launches have occured. SpaceX is the first company that has recovered a capsule after it has orbited. They are also the first commercial company that will dock with a manned space station.
Or to expound on that for a moment, think of Barkley in the holodeck - what are the ramifications of us programming our own psyches of people we know, to have virtual instances of them that we can interact with? How weird/wrong/fine is it to program up some girls you went to high school, but tweak them all to be friendly? I know this is a bit of a rant from the topic of social media familiarizing us with first-person death experiences. It just makes me stop for a moment to contemplate what we really are inside, or what we really arent.
No worries, most people don't want to be entrepreneurs.
There really needs to be a way to sell outside of the apple appstore without needing to jailbreak of your device. If the DOJ can sue Apple and the book publishers over an apparent attempt to destroy competition in the retail market, why wouldn't they be interested in how Apple is destroying developers' ability to freely publish apps and consumers to have choices besides Apple in the marketplace? How do we start a campaign to get them to look into this? Has anyone tried to file a suit of any kind to address this problem to date?
At least in my (former) church, there's a tradition of having a mass for them on the anniversary of their death (first and tenth in particular), and family/friends would gather and make a social occasion of it, which was often quite a joyful affair.
Mobile operators unconvinced by Nokia's revival bid
Unfortunately, the accelerating returns of technology (particularly in computers) means there's limits to imparting specific technical knowledge to the next generation.

I'm not sure how true that is, if you're interested in getting the best results as efficiently as possible.

Knowledge is not the same as understanding. You can know many facts, but if you lack the context to see why they are significant, how they relate to each other, and what you can do with that knowledge, how much is it really worth?

Moreover, there is far more information that is freely and immediately available in the age of the Internet than any human being could learn in a lifetime, or a thousand lifetimes for that matter. There was too much in a single library for any individual to read it all many generations ago. Knowing what knowledge matters to you and what you can skip over and leave for others to learn is very important, and that requires some form guidance and collective wisdom.

Older and wiser generations can help the young to find their path and achieve that understanding, so that those younger generations can perhaps achieve the same level of thinking a little sooner and then have time left to go further than their forebears.
A business is a company formed to search for a scalable revenue model? Ok, that's from a businessman's point of view.

It's also formed to search for a product that resonates with the market. And to search for a capable team. And to satisfy a need by the founders to create something meaningful.

Remove Any of those, and you don't succeed. None are the 'true meaning' of entrepreneurship.
I had a professor like that, he also was a signatory to the original ECMAscript standard. He also claims he came up with that name. Since they were spending too much time debating the name, he figured they'd call it that for now, and since it was such an awful name they would be sure to go back and change it.
The word "apology" almost always means saying sorry, even to people who know the other meaning.

The author might consider the word "apologia", which does not obviously mean saying sorry and has the additional benefit of sounding Greek, stirring up memories of Socrates' famous defense at his trial. But again, there isn't even a defense in the author's post, just the promise of one forthcoming.
ITunes 11 and iOS 6 Coming In June Or July?
I can't remember now why I chose ReadItLaterPro over Instapaper - it was a few years ago, and I think I just preferred the look of RIL, but the name was always less than brilliant, since it was quite generic. Both are supported well by the iPad and iPhone apps I use, although the newcomer that's been getting all the press recently is Readability.

The ReadItLater app has just magically renamed itself and re-iconed itself on my iPad, so well done developers - so far - for making the transfer smooth.
It may be poor advice but it is an option nevertheless. pud asked for what to do next and selling the site is a potential road to take. I'm disappointed that some people have down voted this to death. I am following the rules of the site. I feel bullied after expressing an opinion.
How to Enhance Your Career in Information Security
Create a free account to download for free the whole magazine.
That's coming in part 2, but an explanation of the mechanics is necessary before reaching that point. Since a discussion of the mechanics are useful by themselves, I didn't wait to polish part 2 before posting this one.

My apologies (in the sense of definition 1) to those who feel misled. I'll polish up the actual apology (in the sense of Hardy) post-haste.
HFT would still serve a role with subpenny increments. Nonetheless, the subpenny rule is a very important mechanic in the construction of HFT.
How does the DCPU-16 differ from other assembly languages?
With only 3,000 viewers so far, perhaps it's just nobody's complained yet?
Without finishing the article, or knowing anything about the author, I knew that this couldn't be somebody who has ever tried his hand at starting a business.

The fact that he repeatedly quotes Eric Ries and Steve Blank makes this article a little hilarious to me as well. I for one am only really interested in hearing stories from actual entrepreneurs who have tried and failed or tried and succeeded. Both are equally interesting to me. Academics who have spent their life in office jobs or espousing theories and quotes about how difficult it is do not interest me. Anybody can write about how hard something is from a hundred miles off the ground, but unless you have actually tried, you don't know what you are talking about. This applies to pretty much anything.

It also seems strange to me that he suggests hopeful entrepreneurs should jump from running a business to something useful, like, learning to code. How original. I have been coding half my life. Coding is a means to an end. It solves some particular problems in one particular way. It is not an end-all be-all panacea that picks you up from poverty and moves you into the upper class. Despite what many people think, particularly in the Silicon Valley startup world, knowing how to code is not required to start a business. It is a trade, just like construction, or plumbing, or welding. The only difference is that coding tools are basically free and relatively new. But the law of supply and demand still governs which products succeed.
Some ideas:

Advertising is an idea, but the problem is, that you likely don't want random ads, selling phone sex, or other products a musician does not want.

I bit to late. I would have said "Come to Germany", one to three month ago, "join me at Frankfurt Music Fair, and we hustle around to hunt targeted advertisements, by shaking hand with the right people".

The other idea is to expand the business into a premium membership for live acts. I know that people are willing to pay for listening live to shoutcast streams. Managing shoutcast severs for musicians is one of the many small parts of my income. A good musician can earn about $50 in average per hour, by sitting in underpants in front of his computer, because people love paying tip!

All you need is a premium membership (accept pp and cc from listeners, payout with paypal), an own geoip shoutcast relay network, and charge some percent.

Last is your cost structure. You hobby costs $2,500/month. Thats a lot of money for the cloud trap. Own hosting or even co locating could be much cheaper in the long run. But you need some more admin work.

You can contact me in IRC (freenode #startups) or at my website http://kephra.de/
Android app design is first rate. Taking advantage of the new ICS widgets/design language. Very good.
Tore Anderson's talk on IPv6-only data centre deployments at RIPE64
I'll believe that HFT adds liquidity to the market when the typical start of employment to retirement period is 15 milliseconds.
If the best way you can think of to determine the 10 most popular search queries and their click-through rates involves terabytes of intermediate data for only 10GB of input data, then you're doing something very wrong.
Obviously burning out in 5th is almost impossible, but I was considering the stop sign case where you are starting from rest in 1st gear.
Actually, I have to admit that I haven't seen that film and know little about it. I tried to dig up the exact quote from "This Film Is Not yet Rated" but couldn't find it, so I may have misremembered it.

But the underlying point still stands, even if that film is not a great example. Depictions of war should probably be treated be differently than the kind of over-the-top violence in most action movies that I can only describe as fantasy. Yet the ratings board seems not to take that into account, and just counts splatters of blood in a way that's taken out of context.
It is possible (without jailbreaking) with an enterprise certificate.

But I agree, its ridiculous that you need the manufacturers approval to deploy software _you_ have written on a device _you_ have bought and paid in full.
I have been working on this on and off for a couple of months and finally after seeing a similar idea submitted last week (http://news.ycombinator.com/item?id=3832269) I finished it over the weekend. It's a bit of an experiment with the idea that the server doesn't need or want to know what the content is that is being posted by the users, the page is encrypted and decrypted in the users browser using a key in the url's fragment identifier.

You can see an example document here: https://cryptpage.com/Cvni#GTP9LXTSI1LV5FKlkO8Dpd

The main difference with this to the one last week is that by building it around a Markdown editor it becomes a platform for publishing nicely formatted content on-line in a free and secure manner.

I am not sure who the market for it is yet and I built it mostly to scratch an itch and learn some new tools. I would love to hear what you think!

Some possible things on the to-do list for it:

- Using the HTML5 file system API and DataURL's to allow people to select an image on their computer to embed into the page. Although I am a little nervous about this and how it could be abused.

- Have an option of a wysiwyg editor for editing the pages.

- Allow optional commenting on pages in a way that is also encrypted.

- Allow people to attach small files again using the HTML5 file system API and DataURL's.
Fifth-grader makes video game for blind grandmother
disreputable sex educators?
> "(I'd say the 13 million "SALES" are also an indicator of quality but, Angry Birds aside, there's no way a number that high was all paid downloads.)"

Are you sure? Why?
Eric thanks for the encouragement

Your post gives me a little glimmer of hope. I was kind of hoping this thread would go better on HN and get lots of leads like yours.

Just finding meaningful causes is proving a problem, and at least at first before theres any kind of momentum behind the site its going to rely on leads like yours.

Absolutely any help I can be in getting things posted, please just ping me on my blog or willvarfar at google's free email service .com.
What's she talking about with Django 1.4? Does it duplicate the directories for some reason?
It actually applies in a few cases:

* All wheel drive cars, with all-wheel braking

* Two-wheel drive cars, with braking systems that are primarily biased towards the front.

Both cases rely on either all four wheels or accel/decel or only two
Doctors don't do that, and the acts that medical companies partake to go directly to the consumers are sometimes quite underhanded.

I was listening to an NPR special about a year ago on how, for some high-end medications which now have generics on the market, patients can receive 'coupons' for medications that cover their copays.

What does this mean? Well, for the generic the patient would have paid $7 and the insurance company would have paid maybe $50, for a total cost of $57 (hypothetically. In the case of the branded medication, the patient pays nothing (they would have paid more than the generic, usually twice or thrice the generic copay, but they pay nothing because they have a 'coupon'), but the insurance company might pay out upwards of $850 now, for a medication for which they may have paid $50.

This happens all over the country, and if it's even effecting one tenth of one percent of the US, you're looking at over a billion dollars in unnecessary healthcare spending.

The insurance companies are definitely not the Robin Hoods of the healthcare world, but they're also certainly not the worst aspect of that wasteful industry.
复盛空压机
Fantasies of men
We all know that men have lots of fantasies. Dirty and naughty fantasies. Do you think you know all of them? Well think again.
Video: Goodreads VP on “The Mechanics of Book Recommendation Engines”
I'm bored, so let's run the numbers: the elapsed time between removal from the App Store and removal from Google Play is 23 days, at a point where it had been simultaneously in the App Store and the Android Market for ~450 days (I don't know the exact number), which gives us P = 23 / 450 = 0.05 -- where the null hypothesis is that removal happens at random -- for this within 23 days of each other, and that's on the edge of statistical significance (you usually set alpha = 0.05). So maybe something weird happened.
I use Opera Mobile's site saving a lot. Not sure if it is too similar, but it's all I need.
>We need to discourage those who aren’t fit to start their own business.

I request you to define "fit". How can one know if one is "fit". The line is very blurry I believe, unless there is something that I am missing here.

Not unlike many others here, I aspire to be an entrepreneur too. But after reading this article I am left undecided on what side I "fit" in. Am I not supposed to be doing this? How am I (or others like me) supposed to know? It would really help if there were some questions that we could answer. I understand the answer will not always be yes/no but I have to start somewhere.

The author's main point seems to be that not everyone realizes that chances of success is very very small. But I know that, and I understand that very well. So where does that leave me?

One moment I am absolutely sure I know what I have to do, then I read some article like this and it makes me think. The more I think, the more likely I am to be confused.
There's a viable market for them far outside schools and exams - they just don't often receive attention when it comes to innovation.
IPhone controlled helicopter
I think (b) is the right way. You must generate a win/win for the musicians (sell mp3s and live acts), the listeners (buy music legally and directly), and yourself (some percent)
I was alluding to Hardy's book, "A Mathematician's Apology", not the ancient greek one. I've updated the title on HN as per your suggestion.
Looking forward to good beer and great stories
Have another look at edw519's second point (emphasis added):

> 2. You'll probably have to make time for extra work. Shouldn't be a problem if you're a good programmer in an enterprise.

The point being that you can do these things on company time if you complete your day-to-day tasks efficiently.

Your points are more valid if you substitute 'energy' for 'time' in your reply. If you spend eight hours completely zoned in while working for the man, you might not have much energy left for your personal projects when you get home. You can mitigate this somewhat by working on your personal projects before work.

Or you can take the Einsteinian approach and not sweat your day job while you revolutionize physics in your spare time.
Designer Philippe Starck confirms 'revolutionary' project is Jobs family yacht
How much of Megaupload's usage is downloading copyrighted content?

This article is a little corny. "multi-billion $ IPO" and "reverse IPO" are mutually exclusive. The author spends most of the time talking about accountants and bankes when the primary issue is legal. And the author fails to recognize that such a tenuous business would have a hard time finding investors.
Living with Internet Explorer 6: Six ways to ease the pain
Ugly Meter: How To Make $1/2 Mil Destroying Kids' Self-Esteem - with Jo Overline
Pinterest Is a $7.7 Billion Company
bubble love
Well, it was published in a real journal (Biomaterials) with an impact factor of 7.882. So the research is theoretically peer-reviewed and solid, in that the paper itself isn't just making things up.