skysight-inc/HackerNews huggingface dataset:
I'm certain you could build an embedding that provided a utility function for molecules based on price and synthesizability. That's an approximation of what the chemist's brain is doing.

You wouldn't ask a chemist to evaluate the molecules (in drug discovery), though- you'd have a molecular biologist (really a lab tech) set up a screening campaign, and in many cases, the biological readout that predicts something could work as a painkiller or oncology drug is relatively straightforward to implement experimentally at scale (high throughput screening). Unfortunately those readouts aren't super-predictive of the full biology, however.

I expect DeepMind or Isomorphic to announce, in the next five years, that they have made a model that can quickly identify whether a specific molecule would be likely to pass clinical trials and the rest of the FDA process. With a false negative rate ("predict that a drug would not get through to approval, but in reality it would have") below around 25%, we could easily save billions a year in failed drug costs.
Thanks - that is certainly not a good number i.r.o sales.
It's called 'work' and not 'fun'. Gotta set the expectation that part of the job is not just being a code-monkey but being able to communicate effectively. Time to work on a plan together to improve communication.
Wait until you hear how quickly I can complete crossword puzzles by looking at the answer page.
Golang, Htmx, Sqlite if you want to deploy fast with minimal setup.
For CSS, whatever works for you, but Tailwind / Bulma / Bootstrap are ok.
Even Uncle Bob is correct some of the time. My point being that media over sensationalizes issues and that basing your view on reality through their port window is risky.
Founder of Hacking Team Arrested for Attempted Murder
> If, on the other hand, there is no window and you want one

You rent a different apartment. I don't know what's so difficult about this concept with regard to his building and the need for some people to call it a hellscape. He's trying to offer a less expensive place for people to live for a couple years while they go to school.

A dorm room is not a habitat. It is just one room that someone will occupy for part of their day, mostly while asleep. He hasn't blocked out the sun.
Israel is a rich country, they don't need western support. In fact, western support is probably the only thing stopping them from straight genociding Palestinians. The day their western support ends is likely the day we see the largest humanitarian crisis in the history of the world begin.
Gold Bars and Tokyo Apartments: How Money Is Flowing Out of China.
In the film piracy culture, TS takes on a different different different meaning
Something like a carrier launch catapult, I think, would make more sense to be honest
Or a needle to pop the light.
Google Bans 'Downloader' Again Following Markscan DMCA Notice
> That’s one part. The others are deterrence, incapacitation, retribution and restitution [1].

Deterrence (fail) - 44% of criminals go to jail again.

Retribution (fail) - Not sure what the value of retribution is other than deterrance. See above.

Incapacitation - a substantial number of inmates commit crimes while in prison.

We need to find a better way.
Not too surprising.

IRC has some particular expectations of privacy, including that users that aren't in a room shouldn't be able to read what's going on in the room, and thus archived rooms are an exception rather than a rule.
On any other "social media" they would be great comments, but they're not really in the spirit of Hacker News.
Okay, but who's taking care of the actual host? I know this is HN and we're all server admin wizards, but there is some effort and maintenance required.

This is theoretically even easier than that. Yay for a spectrum of options!
> If you are unemployed and not in school and living alone, watching TV is a default activity.

If you are homebound due to illness or disability, this may be true.

For other groups of people, this is unlikely to be true. Stay at home parents likely have a full day of work taking care of a child or doing house chores.

Being unemployed doesn't mean that you have endless amount of free time either. Applying for jobs and preparing for tests and interviews is itself a full-time job or close to it.
https://archive.ph/Mo4eD
I used BitWarden for a while, but it didn't feel like I was in control.

These days I use KeePass but together with Syncthing to have it across all my devices. It's a bit of setup but I am in control and it works flawlessly.

Last word; check out Syncthing, it really is a ridiculously good software.
Installing Oracle Developer Studio 12.6 on Illumos
Thanks, maybe all of these studies should be pre-LLM'd since my take-away from the title and the article was lidocaine is causing cancer.
I'll scroll through my Google News app and it's riddled with articles describing the approval cost of charging vehicles, of they reliability and cost.

I've been driving a Nissan Leaf for almost 2 years now. Charging is annoying but still dirt cheap, both at home and in the road.

I know I've had this car for less than 2 years but it works fine. It's been great so far and it's probably the worst full EV you can buy in the US.

I find it strange that there are so many alarmist articles saying how EVs aren't the panacea they're cracked up to be. But that was never how they were advertised.
1password family uses a private key as well as a master password.

Good luck cracking that remotely.
I've found the same. I store all raw json output into a sqlite table, create virtual columns from it, then do a shell loop off of a select. Nested loops become unnested, and debugability is leagues better because I have the exact record in the db to examine and replay.

I've noticed what I'm creating are DAGs, and that I'm constantly restarting it from the last-successfully-proccessed record. Is there a `Make`-like tool to represent this? Make doesn't have sql targets, but full-featured dag processors like Airflow are way too heavyweight to glue together shell snippets.
Basically blogspam, original article it's all based on is: https://www.forbes.com/sites/phoebeliu/2023/11/26/this-nvidi...
> Availability is often strongly correlated with technical maturity.

I see what you mean. Yes, agreed.
Also important to remember this is _average_ revenue per user. Consider that the cohort of users that are more likely to pay the monthly subscription are probably more valuable ad targets (more disposable income to spend online)
I dunno if statistical methods can be applied to generating photorealistic images from simulation, where you don't have enough information in a scene, since you are starting with 3d models.
What do you mean when you say the train "should not have been there"?
You missed the part where I said with good tooling. Nothing about a monorepo requires you to have all of the repo accessible to everyone.
Do You Use Okta? Hackers Probably Have Your Name and Email Now
> What happens when your node is down when it was supposed to execute and then comes back up?

If you want at-least-once scheduling you’d probably use a library that writes a last-completed time to your db.

> What happens around timezone changes and leap years?

For wall-time scheduling you’d need to handle it, yes. Why would a service be better than a library though?

> What does this thing do if a run takes so long that the previous run is still going?

I think we’d need either another db entry or simply prevent overlap directly in the library.

> How do you get logs/notifications if it fails?

Same way as other things in your app that fails I guess. Perhaps logging a critical event?

If you’re talking about external health monitoring then yes, you’d need to have a separate service by definition, preferably with a completely different provider/host.
Race to the first "State of AI report" won by Retool! Congrats Retool!
Well, sure, but by that metric this library is even easier to build yourself since it's only gathering a single stack entry per wrap. And it has no backwards compatibility to worry about.

"You can build X by hand too" has little to do with why people choose to create or use libraries.
Also, you go for Audi (standard models) mainly for how chassis is modeled (aka looks), internals of VW conglomerate are almost identical to cheaper VW or sometimes also Skoda or Seat.

Interestingly, one of my colleague's worst car experience was Audi, not sure if A1 or A2, but he was very disappointed how unreliable it was. Case point 1.
Does anyone know what kind of compiler support exists or is planned for these?

Edit: https://en.wikipedia.org/wiki/Loongson#Compiler_support
Yarn@1 has this autoclean feature: https://classic.yarnpkg.com/en/docs/cli/autoclean

I used to use it, but at some point the hassle of the occasionally breaking package wasn’t worth it.
Write what you need in the first sentence.

Maybe include extra detail below, but reduce it to one sentence. You need something, ask for it.

Honestly, it's the biggest part of business communication. That first sentence.
> it is time for a new machine if the hardware is as old as the operating system.

Under the reasonable assumption that they are a typical "elderly user" then the hardware itself is likely more than capable of handing their use, and were it not for Microsoft artificially imposing requirements that obsolete lots of older hardware, all they would really need is an OS upgrade.
GhostBSD 23.10.1 Review on DistroWatch as Feature Story
Sure. We still update the software. The tool which airlines use to create update blobs is even online [1].

> Because we can't realistically bring them back

We couldn’t always OTA spacecraft. Back then we just lost them.

The point is in even high-stakes games we don’t write flawless software. Now software in cares is doing more. There will be bugs. Pretending there won’t is delusional.

What we can do is minimise safety-critical bugs by forcing standardisation and certifciation in those components, even if that slows down innovation, and ensuring timely patches. That’s easier with digital than analog, which in turn makes manufacturers more willing to admit they made a mistake.

[1] https://www.boeing.com/commercial/aeromagazine/articles/2010...
First, very slight correction to the thread, most civilian craft have transponders, not IFF. They're kinda the same thing in practice but transponders just give out a static number, IFF is a cryptographic challenge response.

I don't know how the navy does it when abroad, but anything entering or leaving a sensitive area will generally be on an ICAO style flight plan (entering US ADIZ/TFRs/DC SFRA etc) and it's a simple matter of checking to see if the thing responding with "hi I'm mode c or s (civilian aircraft) 1234" is doing what it should be.

There are also some other sidebands that get used like NCTR which looks at the radar return to attempt to identify the type of aircraft but they weren't well developed in the 80s.

If the aircraft is not responding at all to transponder interrogations you can assume it's hostile and presently attacking you or the pilot is forgetful and didn't flip the switch (choose wisely).

You can obviously put a mode c/s civilian transponder on a cruise missile or better yet fill a remotely piloted 747 full of explosives if you're feeling especially squirrelly and that's totally been done. That's also part of why these events keep happening, everyone's kinda understandably jumpy.
When you post an affiliate link it would be nice if you stated so.

This has the affiliate tag of: pmg097-20

Without any affiliate link it is:
https://www.amazon.com/DYMO-Authentic-Industrial-RhinoPro-18...
Two peers is maybe too small a group. Take 5, 4 of which think one way and 1 another. A decision must be made by end of day. By the end of the day, the outlier may not be convinced, but they should "disagree and commit" to working toward whatever the decision is.
I had that, but found the archive.org page and pulled the links to the mp3s from it which were actually still live. I won't say who it was because they likely cleaned it from the internet to clean up their image. It was glorifying the confederate flag and stereotypical redneck culture, which I see as a hilarious meme "Billy's mom gave him a shotgun when he was 3 that's why we call him shotgun Bil-leeeeee" :D
Boats do, but trains are mostly electric.
For those curious what he tweeted/Xed it's here https://www.vice.com/en/article/pkavwm/elon-musk-endorses-co...
I don't think many people would choose to start writing a new CLI in C++. That's just making things difficult for yourself.

There are some domains where I might still pick C++ over Rust - especially games and GUIs. The Rust ecosystem for those hasn't matched C++ yet.

But not for a CLI app. Especially one like this that doesn't have any difficult dependencies.
If you know what apoptosis is, then it's pretty obvious it's the opposite. Apoptosis means programmed cell death.

"Lidocaine induces programmed cell death in head and neck cancer" is pretty clear.
Hybrid motors take a lot of stress from the ICE during load changes. This makes the ICEs potentially live much longer. A lot of taxis areound here are older hybrid Toyotas. They must have at least 400,000km mileage already.
Current Time Series Anomaly Detection Benchmarks Are Flawed
This article is consistent with my recent experience with academics being in a frenzy to produce papers riding the AI/ML hype, yet producing bunch of practically useless papers.

The following quote from the article is striking: "Qiu et al. introduce a “novel anomaly detector for time-series KPIs based on supervised deep-learning models with convolution and long short-term memory (LSTM) neural networks, and a variational auto-encoder (VAE) oversampling model.” This description sounds like it has many “moving parts”, and indeed, the dozen or so explicitly listed parameters include: convolution filter, activation, kernel size, strides, padding, LSTM input size, dense input size, softmax loss function, window size, learning rate and batch size. All of this is to demonstrate “accuracy exceeding 0.90.” However, as we will show, much of the results of this complex approach can be duplicated with a single line of code and a few minutes of effort."
I'd hold off on declaring that the EV boat has departed. It remains to be seen at what level EV uptake will plateau, without major advances in battery tech and EV practicality. Coming from a rather nippy Canadian city which bought a bunch of electric buses, fucked up badly[0] and probably made purchasing more electric buses an untenable proposition for (conservatively) 5-7 years, and having heard from multiple EV owners about the less glamorous aspects of EV ownership in Canada (charging cost/duration/convenience, battery performance in cold weather, skyrocketing insurance and repair costs)... The boat, far from being missed, is still in the dry dock.

[0] https://edmontonjournal.com/news/local-news/more-than-half-o...
I think this is "how to think about coding assistants and your task" but none of this is "tackling" their unreliability.

While coding assistants seem to do well in a range of situations, I continue to believe that for coding specifically, merely training on next-token-prediction is leaving too much on the table. Yes, source code is represented as text, but computer programs are an area where there's available information which is _so much richer_. We can know not only the text of the program but the type of every expression, which variables are in scope at any point, what is the signature of a method we're trying to call, etc. These assistants should be able to make predictions about program _traces_, not just program source text. A step further would be to guess potential loop invariants, pre/post conditions, etc, confirm which are upheld by existing tests, and down-weight recommending changes which introduce violations to those inferred conditions.

ChatGPT and tab-completion assistants have both given me things that are not even valid programs (e.g. will not compile, use a variable that isn't actually in scope, etc). ChatGPT even told me that an example it generated wasn't compiling for me b/c I wasn't using a new enough version of the language, and then referenced a language version which does not yet exist. All of this is possible in part b/c these tools are engaging only at the level of text, and are structurally isolated from the rich information available inside an interpreter or debugger. "Tackling" unreliability should start with reframing tasks in a way which lets tools better see the causes of their failures.
Could you recommend a good book or online learning resource for Flutter?
> Why do you think the median age in Palestine 19 years of age?

Well this is because Hamas has a very explicit policy goal of massively increasing their population to make it harder for Israel to kick them out. Their birth rate is madness.
Wasn't that the original purpose?

Hubble is a refurbished spy satellite, right?

PS: Moving imaged subject can be fixed with Point Spread Function.

https://en.wikipedia.org/wiki/Point_spread_function
Someone must have made a dongle that you can plug into the USB port of a machine. The dongle also has Bluetooth connected to your phone, and the dongle acts a virtual keyboard. So your phone can send over Bluetooth what to type, and dongle types that into the machine.

Or Bluetooth controlled robot hands. I will go with the latter.
people talk, and word will get out. you can only bribe your way out of so much.

if it's just going to a bank account somewhere though, whatever. keep your mouth shut, tell em you're getting $3.24/hr, and then go on a bender when you get out with all that saved up cash.
Wasn't there something like this a while back where somehow had designed an "xray scanner" that used peoples wifi routers to do it?
"The propagandists who create such images are skilled at targeting people’s deepest impulses and anxieties, said Imran Ahmed, chief executive of the Center for Countering Digital Hate, a nonprofit that has tracked disinformation from the war. Whether it’s a deepfake baby or an actual image of an infant from another conflict, the emotional impact on the viewer is the same."

That's why I too have emphasized the human role; to exploit these weaknesses in people -- at the scale of nations and not individuals as is common in social engineering -- is to have a good social science understanding about a particular nation, including its culture, history, and residents.
FDA Investigating Serious Risk of autologous CAR T cell immunotherapies
Evernote Free accounts will have fifty notes and one notebook
Randalizing the intertubes!
JSON does not define a precision for numbers, so: it's often float64 (but note -0 is allowed, but NaN and +/-Inf are not), but it depends on your language, parser config, etc.

Many will produce higher precision but parse as float64 by default. But maximally-compatible JSON systems should always handle arbitrary precision.
This has been common in the US for at least a decade now.
Yes, the paper linked to by firebirdn99 is much more recent and shares an author.
Something similar for piano learners would be welcome
Show HN: API Dash – An Open Source API Client Built Using Flutter
Hi folks,

I have been building API Dash, an open source alternative to Postman, for less than a year and I am super excited (& nervous) to share it with the HN community.

Currently it has the following features:
- Collections & Folders to manage API requests
- Interactive JSON response previewer
- Multimedia response previewers (40+ mimetypes supported)
- Dark mode support
- Client code generation (cURL, Dart, Python, JS, Kotlin, HAR)

It is the first API client that has been built using Dart & Flutter and I would love to hear your feedback. Thanks!
That was my first take as well!
Why does it feel like it's moving in such jerky steps?
sounds to me more like the army, but there often isn't much difference...
Israel would be far more violent toward Gaza if they had no western support. Ironically the US military aid is actually whats stopping them from flattening Gaza here.
Individual contributors, you should be aware of DORA metrics
My girlfriend bought her Toyota corolla for 5000 bucks some time ago, old, used, and soon started showing engine warn sign. Pretty bad if you ask me. Yet that light never manifested into anything real, 80k+ km down the road, still works reliably (technician couldn't find anything and just resetting it soon brought it back).
Does the rollout from 0 - 200mph takeoff speed really use the bulk of the takeoff energy? I figured most of the energy went to climbing 6 miles in altitude.
This gave me an idea, what about a game that is proceduraly generated in whole, maybe using only the same underlying mechanics, for each run of the game or each person that plays? It’ll probably be possible in not too long with generative AI.
This is already happening all over the world across multiple industries. It's typically called lab-in-the-loop.

I have been involved in projects with eccentric billionaires to build such things. It's challenging to make forward progress in a meaningful way (IE, beyond a press-and-paper prototype), and often the reasons are entirely banal and provincial (many scientists in the field feel threatened by ML and automation; others just don't know how to work in a large-scale environment, others want to come up with the perfect experiment yet never actually run one, and even others want to use the automater as a quick-turn-around, not economy-of-scale tool. Further, just getting the necessary support infra to make the system run well can often be quite challenging.
Trait system?
Craigslist needs to be added to the list of national historical sites and should _never ever_ be allowed to change.
From the wiki: “Rogers' next assignment was as commanding officer of the United States Navy Tactical Training Group at Naval Base Point Loma, a group responsible for training officers in handling combat situations.”

Is having that guy train people genius, or moronic?

https://en.m.wikipedia.org/wiki/William_C._Rogers_III
Eh. Military aircraft would also have a transponder, they just wouldn't necessarily have active broadcasts.

Civilian aircraft do broadcast actively (ADS-B). But they also respond to secondary radar for Mode A/C, which are basically cases of IFF Mode III (okay, maybe not exact term, but the idea applies.) So it's still a challenge-response/IFF, just in this case always responding.

Military aircraft use different modes and presumably don't respond unless interrogated with an appropriate challenge, but the principles are the same.
Steve Huffman. Nothing too controversial in the last couple of months I think.
I absolutely agree, but I find the situation incredibly funny. There are three characters here: me, the LLM, and the compiler. Two of them are robots, but they refuse to talk to each other - it's up to me to tell the LLM the bad news from the compiler.
Software (plugging in a cable and a computer) and other 100k+ mile (suspension) if not lifetime (battery coolant or oil, airbag recall) seem seldom and low rate activities not enough to keep a dealership service department running.

Tesla is often solving these with mobile mechanics and regional service centers.
> referring to "FSD" doing absolutely bullshit things like not detecting objects in the way

Did Consumer Reports look at FSD? I don't think optional features like that factor into reliability.
Oh it's definitely more than $50.

I have done my oil changes in the past, and for the recommended oil and filter on my 8 year old Toyota, $50 would cover 5 quarts of oil and a cheap filter. Add in disposal + labor, it's sometimes just easier to pay my local mechanic the $75 for the oil change.
It does not require a facebook account. It uses a separate meta account.
And at a proper airfield it wouldn't need to use nearly as much g-force, since you can accelerate at a slower rate when you have a runway.