skysight-inc/HackerNews huggingface dataset:
Nobias Therapeutics | Norcal/Mountain View/Palo Alto/SF; Philadelphia, PA; other locations welcome - particularly Boston, MA; Miami, FL; Austin, TX; REMOTE also acceptable (US, Canada, London/England, other countries considered on a case-by-case basis) | Full-Time | salary + equity

Hello HN! We have hired a number of people from this monthly "Who is hiring?" post. Please don't be put off by how spare our website is. We are doing very exciting work at the nexus of biology and computer science, and we would love to talk to you. If you've reached out recently but haven't heard back, we appreciate your patience as we work through a backlog of submissions. We have primary offices in Mountain View, CA and Philadelphia, PA - so even though we have a number of remote and hybrid employees, we're particularly excited about hiring local people.

Nobias is a new pharma startup using a variety of built-from-scratch, custom AI tools to speed drug development. As an early stage biotech, we use large repositories of biological data, bleeding edge deep learning techniques, automated reasoning, and computational biochemistry to discover and develop new medicines, diagnostics/biomarkers, and biological insights for a variety of diseases, particularly pediatric rare diseases. If you have strong programming chops, a background in machine learning, and deep knowledge of biology or computational chemistry, we would love to speak with you.

Multiple roles are available - right now we are particularly concentrating on expanding our stable of AI engineers who have deep expertise in modern ML techniques. You should understand these techniques at the deepest level possible, and be able to extend existing research and construct new concepts from scratch, while also understanding cell and molecular biology very well. Finally, we are also recruiting for a leader in Translational Research. This position will focus more on outstanding biology knowledge and the process of moving from concept to validation.

[our domain is nobiastx.com - our website is in flux, so please excuse the lack of detail!]

Please contact us at hn_recruiting {@} [our domain].
I've spent $20 on British-made hand polished plastic combs, but that's my limit. Worth it for comb snobs like me. I suppose everyone has different standards for luxury.
I guess its cheaper than buying your Mom a Mac.
Emulating Shell Worksheets in Vim
That's my policy, one way or another I'm downloading a copy for safekeeping.
> It seems that cooperative altruism and out-group violence are both innate to some extent.

Some extents are longer than the others, seeing as of the societies we see in the animal kingdom and are currently able to be studied with current tools point to "patriarchal" societies being more common than "matriarchal". In the case of bonobos, which are known to be unusual in the ape world.

> Ecology and society determine how we realize those traits - in times of intense competition, we resort to tribal warfare. In times of plenty, we cooperate.

Please state this is an opinion, it looks like you're asserting it which is rather large mistake.

> It should also be noted that Chimps and Humans are among the few species (perhaps the only mammal species?) that exhibit this tendency to wipe out their competition with systematic violence. IOW it's not just competition for resources in the moment - all animals do that. It's the sustained desire to wipe out the competition completely (effectively, genocide) that make both Human and Chimp violence rather unique in the animal kingdom.

Unless you cite this, I would also lump it similar to above.
What does Lancet have to do with this?
I find it endearing, fascinating but ultimately tedious that the Japanese put SO much effort into both seemingly mundane AND intricate objects.

I realize that it's more a combination of tradition and their self imposed ~exile~ (isolationism, corrected) from the world for a long time.

But there must be a reason why they excel, I mean really excel at anything they put their minds to.

Their population also tolerates this! These businesses stay in business!

Just to name a few things they're still unbeatable at:

1. Pens (This is a rabbit hole, buyer beware)

2. Paper (Midori! oh Midori)

3. Architecture (a function of their location, but none-the-less)

4. Art (manga, cartoons, all invaluable part of the pop culture even today)

5. I don't partake as much, but their food is unbelievable.

There's just something about their tenacity that we can take a morsel of.

edit: Corrected from exile, to isolationism.
Also, I did forget about photography! (Nikon!) and chalk!
All credits to people(ai?) in the comments below for these edits.
They put a ton of effort into supporting the Linux desktop market, all considering.
Location: Honolulu, HI
Remote: Remote, hybrid, or onsite ok
Willing to relocate: No
Technologies: Typescript, Python, React, Vue, Django, SQL, GraphQL, AWS, many others.
Résumé/CV: https://arclight.industries/Seth_Ladygo_resume.pdf
Email: seth-hn@arclight.industries

Longtime veteran of the mission-driven startup world as employee and
cofounder. Recent experience in YC-funded biotech and medtech. Primarily
a full stack software dev but I enjoy wearing lots of hats across the
organization. Plenty of experience leading products from conception
through delivery. I'd love to find a humanitarian mission to put my
energies behind.
> Onyx can be used in an entirely different environment without any of these things. In fact, the standard libraries are (almost) entirely separate from the compiler (i.e. the compiler makes no assumptions about what the standard library is), so if the standard library does not suite your use case for one reason or another, you can write your own. It will be a bit of work, but there would be nothing in your way.

Isn't that true for most native languages as well ? C++ have multiple stdlibs.Rust,C and c++ can be used against bare metals.

The orthogonality of the std lib and the compiler and language semantic (maybe at the exception of the types) seems pretty common these days.
There's an old but still gold video from Millet with some pretty cool stomach-churning footage https://www.youtube.com/watch?v=ISagf2eCzKg
They put a lot of work into maintaining a Linux driver, actually.
This seems to just be a link to the Unsloth Github repo[0], which in turn is the free version of Unsloth Pro/Max[1]. Maybe the link should be changed?

[0]: https://github.com/unslothai/unsloth
[1]: https://unsloth.ai/
An easy to use tool to change the behaviour of your input devices
This is a non profit which charter places certain values above the reputation of the organization.
The board members should arguably not have been riled up by the article
I have a corollary to this: there are a series of exponential increases in usage counts between each of:

1. Language designers & standard lib developers.
2. Shared module or library developers.
3. Ordinary developers.
4. End-users.

For many languages, the ratios are on the order of 1,000x at each stage, so for each 1x language designer there might be 1,000 people designing and publishing modules for it, a million developers, and a billion users. Obviously these numbers change dramatically depending on the specific circumstances, but the orders of magnitude are close enough for a qualitative discussion.

The point is that the tiniest bit of laziness at the first or second tiers has a dramatic multiplicative effect downstream. A dirty hack to save a minute made by someone "for their own convenience" at step #1 can waste literally millions of hours of other people's precious lives. Either because they're waiting for slow software, or frustrated by a crash, or waiting for a feature that took too long to develop at steps #2 or #3.

It takes an incredible level of self-discipline and personal ethics to maintain the required level of quality in the first two steps. Conversely, it deeply saddens me every time I hear someone defending an unjustifiable position to do with core language or standard library design.

"You just have to know the full history of why this thing has sharp edges, and then you'll be fine! Just be eternally vigilant, and then it's not a problem. As long as you don't misuse it, it's not unsafe/insecure/slow/problematic." is the type of thing I hear regularly when discussing something that I just know will be tripping up developers for decades, slowing down software for millions or billions.
swyx! I can't believe I missed this post. This is gold. Thanks for sharing!
Exploring AI development 1 year after ChatGPT and analyzing Cyber Week insights
A New Way to Trigger a Tsunam
https://www.bbc.com/culture/article/20180207-how-americans-p...

What accent? Whose accent? Brits are as diverse accent wise as Americans, London, cockney, New England, Southern...

A lot of Indians that I know have a very "proper" British accent, one that maybe a bit aristocratic, its quite an irony for a former colony.
https://www.bbc.com/future/article/20220915-what-the-queens-...

The context matters, but so does history.
> Not sure how someone can write an article on the shift towards more conservative politics and fail to mention that the individual income tax rate for the middle class in the Netherlands ($75k+) is nearly 50% now. And that's just the income tax.

Think of all the free* healthcare though.
Uber did cabs better... can they do an equivalent for public transit?
When thinking about what governance structure to use for our hackerspace, we thought about RFCs for a bit, but I'm glad we went with something different.

RFCs give way too much power to people who like to argue. This quickly kills enthousiasm in people proposing change.
VW won't warranty it (due to the suspension not tuned for it), but a Golf GTI can tow 2,000kg. So for many boats, you don't even need a stupid truck.

Had people wanted cars that are practical, they'd get minivans (and vans, if you do haul a lot).
Are you likening child labor to the public education system? That is absolutely preposterous and I’m not sorry if you’re offended.
The "terms" of the enemy are an abrogation of sovereignty to Russia to create its "russian world". Russia wants to have its own dedicated sphere of influence and feels that the world owes that to it. You don't placate a bully by giving them exactly what they want after they punch you in the face. They'll just come back for more later with new greater demands.

Tons of European countries have all sorts of historical claims all over the territory in Europe, including Russia. They've fought over the territory for centuries. Then they decided after Europe was basically destroyed in war that they don't want to repeat that, other than Russia who still maintained its imperialistic thinking. We're in the last dying gasps of that. The worst thing to do would be to encourage it by giving them what they want.
I’ve used 12ft.io a few times and it seems cromulent.
I assume joining the SP500 means an almost automatic price jump, since its shares will be purchased by ETFs that track that index?
It's using FreeBSD's existing Linux compatibility layer, so it's less "building Linux compatibility" and more "making sure they don't break the existing Linux compatibility"
More precisely, tidal gravity is spacetime curvature.

What most people think of as "gravity"--for example, feeling weight when you are standing on the surface of the Earth--is actually non-gravitational forces, such as the Earth's surface pushing up on you, that are keeping you from freely falling. If you are in free fall, the "force of gravity" as people normally think of it disappears. (This was the key insight that started Einstein on the path to General Relativity.) What is left over is tidal gravity--freely falling objects converging or diverging because of the geometry of spacetime.
I think it disappears not when you move away from SPA's but when you move away from some high interactivity features products that are amazing to use often have.

This especially becomes true for products that are expected to work in low internet zones.
SEEKING WORK | Seattle, WA/Remote

I'm Zack, a full stack Web developer with 10 years of experience. I'm proficient in Elixir, Node.js, and Python, but open to learning anything. I consider myself a generalist able to jump into any project. I've refactored legacy systems, created greenfield apps, and maintained web apps. In my spare time I’m making a little scripting language in C.

https://zjm.me | z@zjm.me
Iterative.ai (Series A) | REMOTE, WORLDWIDE | FULL-TIME | OPEN-SOURCE

Developer tools for ML engineers. We need people who are passionate about building infrastructure that help ML teams manage data (large scale), make sane reproducible workflow, track models. We are building infrastructure to deal with datasets of the 5N LAION scale. Our flagship open source tool- DVC.org (12K+ stars), SaaS product - studio.iterative.ai.

We are looking for senior (SaaS and open source) engineers:

https://iterative.notion.site/Iterative-ai-is-Hiring-852cb97...
Well said. Users pirating content vs the largest companies on earth fucking users in every way they can possibly get away with is a great example of "one death is a tragedy, a million is a statistic".
I don't think i fully agree. Yes it might be possible to design a programming language that have a better synergy with wasm than the one we currently have, but IMO this won't have a particularly big impact on dev prod or performance.
wasm was design to be the target of current languages, so in a sense it does capture a lot of things that already exists or can be mapped easily to existing languages. Designing against wasm might create a case of overfiting. But only the future will tell.
Have you ever looked at adding a semantic layer on top of a db for those that prefer to avoid direct SQL?
1. Privacy: mac/windows requires an online user account sign-in and have built-in telemetry that can't be disabled. 1984 is your reality on these OSs, particularly a problem outside of the free world.

2. Hardware lifespan: apple or microsoft get to decide when you buy a new computer instead of you and the community. Annoying, expensive, and not environmentally friendly.

3. Customizability and control: can't fix or improve the OS, and many powerful features just don't exist.

4. Open knowledge and human progress: by sharing knowledge and allowing others to contribute, we collectively advance. Proprietary operating systems discourage progress, and open source ones facilitate it. Nearly all of the great apps you know and love exist because of the culture of sharing. Even the proprietary OSs only exist because of open source OSs and libraries as the foundation and inspiration.
Server workspaces vs local workspaces, maybe? With server, your local copy was marked read-only. Don’t recall if you could change that flag to edit anyway. We moved to local workspaces as
Quickly as we could - that was a more typical offline edit, resolve conflicts at commit model. Don’t remember all the details, been 5+ years since I did anything with TFS.
Yes because they understand the point of life. It is the creating and the making that makes things worth living. That is why chat gpt and similar tech is going to make our lives more meaningless. Writing and struggling and completing the poem is itself more than half of what makes a poem worthy. The final artifact which chatgpt provides is meaningless without that effort.
The 2nd and 3rd examples make no sense to me.

echo '{"a": 1, "b": 2}' | jaq 'add'

3

Construct an array from an object in two ways and show that they are equal:

$ echo '{"a": 1, "b": 2}' | jaq '[.a, .b] == [.[]]'

true
Location: San Jose, CA
Remote: anywhere
Willing to relocate: yes
Technologies: Google analytics, hubspot, salsaforce
LinkedIn: https://www.linkedin.com/in/aradtal
Red means stop, green means go… unless you are red-green colourblind.

And a quick google search shows that about 8% of the population has some form of colourblindness, while about 1% are in wheelchairs. Additionally, while it’s easy to differentiate between an icon of an able bodied person walking or standing still, there is no clear distinction in an icon of a person in a wheelchair.

So overall this is less inclusive and more confusing - but it made some people feel like they were helping.
The Cybertruck Is a Disappointment Even to Cybertruck Superfans
Man, I've been designing solar+battery offgrid installs for a few years up to my ears into battery datasheets. And I tell you, thermal is critical for the performance.

The phone can't get the current it needs exactly because the temperature is out of spec. This is the definition of "battery stopped working".

Now if you've got a tesla-sized one, and it has a good load, then you have another problem - you have to cool it, or it shoots above 50C and you get a dead battery eventually. I can imagine a 80% charge battery of this size heating itself in a few minutes of load even from -50C. Won't get the usual 2K cycles to half capacity in those conditions, but the car will still move. A bit.

In other news, Norway is overrated wrt colds courtesy of Gulfstream. Compared to say northern Kazakhstan it has a nice mild climate.
I don't blame ya.
You're at least a decade late if you think "hacking" (in the sense of building things) is going to get you out of this situation. The problem with these platforms is network effects and lack of interoperability and not in the technical effort required to build an alternative.

This is in fact where regulation can help (and like the EU's DMA already attempts to) get us back to a state where you can actually "hack" your way out of it by building an alternative that will be viable because it can interoperate with the incumbents.

---

Or, are you suggesting piracy? I mean I sure know what to do, but none of my non-technical friends know, and frankly I'd rather live in a world where I can just pay a reasonable sum and not have to spend time maintaining a Plex/Jellyfin/*arr stack.
Building a Self-Hosted AI Security Cam System with Rpi4, OpenWRT and WireGuard
Manga's complete and total dominance over western comics has certainly been something to see, it's not even a competition anymore! A single issue of 'lower selling' manga can dwarf the entire run of a 'popular comic'. All this happening during what may be the peak superhero popularity (not today but past ~decade).
If this were surprise news maybe, but this is the type of news that is priced in slowly over time and somewhat expected. Basically when sophisticated people bought uber a year ago one of the drivers of a higher price was the assumption it might be included in the S&P500.

A lot of things in finance and markets are self fulfilling prophecies like this, for example just look at the fed. They are the classic example of expectations > action.
More accurately: probably referring to the length of their rope (and thus max pitch lengths). With alpine climbing, the actual pitch length can be all over the place due to a variety of reasons.
You're right. Far too lax in my wording.

s/majority owned/major shareholder/
Weekly reminder that if buying isn’t owning, copying can’t be stealing.
To me, Japan is just this weird combination of utter refinement (which, yes, leads to prices for some things that seem beyond remotely rational) and complete kitsch. I like traveling to Japan now and then then but it seems a bit both alien and difficult in a way most countries aren't.
I fell for this, though I realised it was a scam in time and locked my card quickly enough that I didn't lose any money.

I'm pretty sure it's the first time, in over 20 years of using the internet, that I've fallen for a phishing scam.

It completely gets through your defences because the message is sent via the Booking.com app and is about a legit hotel booking you've made. Very nasty.

But very poor of Booking.com to not be better at detecting these messages. The first consumer reports I can find about this scam go back to January [1], and it shouldn't need very sophisticated text classification to recognise and block them.

More details about the scam here [2].

[1] https://insideflyer.co.uk/2023/01/beware-of-this-booking-com...

[2] https://perception-point.io/blog/booking-com-customers-hit-b...
Piracy is an act of robbery or criminal violence by ship or boat-borne attackers upon another ship or a coastal area, typically with the goal of stealing cargo and other valuable goods.(1)

This term was coopted by the MAFIAA because literal descriptions such as file sharing or unauthorized copying are not objectionable to the general public who see them as minor / insignificant and thus are not sensational enough to draw the outrage needed to enact disproportionate criminal penalties(3) and thus preserve their monopolistic(2) profits.

1 - https://en.wikipedia.org/wiki/Piracy

2 - By way of ridiculously long copyright terms or distribution oligopolies / monopolies

3 - See 'conspiracy to commit' charges carrying de-facto life in prison penalties
One of the most risky sources of electricity is hydroelectricity, because of a very small number of dams collapsing, and all that stored energy being channeled along the river in the form of fast-moving water.

So, you say bluefirebrand was downplaying the Fukushima disaster. Sure. I can say you're downplaying the Fujinuma Dam, which I'm mentioning because it was destroyed by the same earthquake as damaged the reactor, killing 8 in a downstream village.

https://en.wikipedia.org/wiki/Fujinuma_Dam

It was a very big earthquake. The Fukushima reactor should've been built with that in mind, so nobody gets a free pass on this, I think it is a valid example of "even rich developed nations don't explore and plan for all the risks correctly". But still, the earthquake itself caused way more damage than the reactor.
Airlines Race Toward a Future of Powering Their Jets with Corn
When I see the phrase "heavily-accented English" I think of Scottish and Geordie speakers. Extremely few of the Indian/Nepalese/Bengali/Pakistani speakers I have known have such a strong accent that it makes it difficult to understand. At least the younger ones.
https://archive.ph/9LkA1
That's an interesting idea - I guess when it's all shut down, simply copying everything can't really fail or break anything.

Since I'm using the same setup (docker compose for nextcloud, MariaDB, and some other stuff), maybe I should really look into that option, thank you!
Gotcha. Thanks for the clarification!

> if you’re planning to be a top 10 site on the internet, you’ll need a custom stack.

And yeah, that's what I thought the OP was hinting at (or at least hoping to become).

It'll handle small-medium scale forums just fine. Probably any stack would.
It's worth mentioning the altitude. I climb several grades less at ~3000 meters (Colombia) than near sea level (Chattanooga, New England, etc). I cannot imagine what climbing at 6k meters+ feels like. And these guys are hauling gear with no margin for error.
That is a good point. I don't do a lot of embedded bare metal work, so I kind of forgot that is possible. I guess it's something that is not unique to Onyx, but a good thing to know nonetheless.
The critical factor is weight. Electric heated gloves only work if they have power. Batteries are heavy.

Water and fuel are also heavy, which means climbers on big routes like this are usually riding the edge of starvation and dehydration for days, which further raises the risk of frostbite in extremities.
Sounds like a CEO of a hyped tech company.