skysight-inc/HackerNews huggingface dataset:
I work in drug discovery (including in oncological indications), so it's always great to see new research with early, promising results!

To summarize the paper: some gastric cancer models are sensitive to all-trans retinoic acid (ATRA). ATRA is an active metabolite of vitamin A, and is already used clinically to treat some hematological cancers. The researchers tested the compound at several concentrations on a number of gastric cancer cell lines, where they show moderate to significant reductions in growth (from 30% to 60% reduction). Next, they tested ATRA on xenografted tumor cells on immuno-compromised mice, where they also show a reduction in tumor size. They hypothesize that ATRA exerts its effects through immuno-modulation.

Firstly, very cool, and congrats to the authors - I definitely see first evidence of the potential of ATRA to treat gastric cancer.

While I might have misunderstood some parts, I do think there are some elements that warrant precautions here: 1. we can see that some of the untreated mice also show reduction in tumor size, albeit less significant, meaning there could be issues with the cells or protocol, 2. I find it hard to conclude anything about ATRA exerting its effect through the immune system in a study of cell models and immuno-compromised mice.

Nevertheless, given the frankly poor prognosis of gastric cancer (many patients in early stages of the disease now get their stomach removed, and more often than not, these tumors metastize aggressively), and the well known safety profile of ATRA, I think the study is very welcome, and should warrant further investigation. Given the hypothesized mechanism of action, I think testing on humanized mice, using more and more distinct patient-derived cells would bring convincing proof to move ATRA forward to clinical trials.
What qualifies Loeb's work as pseudoscience (which is different from erroneous science as pointed out in the paper and blog post he reacts to) ? The thematics he chose to explore. He could have worded his paper differently, totally burying the extraterrestrial tech hypothesis he had in mind and there would have been no repercussions. Your opinion is driven by the semantics of the topic at hand and its success relies on the fact it fits into two heavily imbalanced classes. Of course I can go around and tell people they don't have that super rare disease: that doesn't mean I'm not a crank too.

Still waiting for you to delve into the details of the argument against Loeb's claims rather than using broad and easy categorization (which etymologically means accusation).
It is a matter of priorities. If that was a high priced Bentley where the customer doesn't expect anything but the best for their money, sure, go ahead.

But for a Model 3 where you need to carefully manage costs or you will either price yourself out of the market (and Tesla is already at the high end of it!) or go bankrupt I think you will have much bigger fish to fry than dealing with such noises.

You also obviously don't understand the engineering decisions - e.g. having the high voltage always on is not possible/allowed. It is a legal requirement because it must be possible to disable the high voltage circuit when doing maintenance on the car - or in the case of an accident. And it needs to switch off the moment the airbags activate, it is not only there for the firemen to turn off.

Also having the high voltage circuit off when the car is parked reduces the risks of fire should anything happen (malfunction, another vehicle crashes into a parked Tesla, etc.)

Manual lever is of no use in such situations. Pyrofuses Tesla already has.
This is very subjective.
France may officially disagree but I think most reasonable people will at least partially agree that the Treaty of Versailles was a disaster and was the actual cause of what happened next.

> Prominent economists such as John Maynard Keynes declared the treaty too harsh, styling it as a "Carthaginian peace", and saying the reparations were excessive and counterproductive. On the other hand, prominent Allied figures such as French Marshal Ferdinand Foch criticized the treaty for treating Germany too leniently. This is still the subject of ongoing debate by historians and economists.

https://en.wikipedia.org/wiki/Treaty_of_Versailles
Frame this north American style. The poorest voted for it because it was in their interests
All-trans retinoic acid (ATRA) is a form of Vitamin A which is used to treat one particular type of leukemia. This group tested it against some gastric cancer cells. Not sure why it's on the front page of HN.
Smart people are equally greedy and corruptable.
Worth mentioning that After Effects can export CSS/SVG/canvas animations with the free bodymovin/Lottie plugin. This is my personal go to for creating web key frame animations and elements.

Not every after effects feature is exportable, but it’s the best and most reliable solution I’ve found for this type of workflow, maybe due in part though to my previous experience with AE.

Currently supported features: http://airbnb.io/lottie/#/supported-features
They voted for it because they were propagandized into believing it was in their interests.
A Spline That Lowers to Quadratic Curves
> shivering is an excellent strategy to avoid death, but it’s a terrible strategy for actually feeling warm.

Sounds like an excellent survival strategy - saves you, but leaves discomfort so you have an incentive to get somewhere safer.
Though not a measure of IQ, the USA used to require landownership as the litmus test for voting. It might be a similar enough metric.
It has been a long time since you last sniffed 9x Windows, right? It will speak NBFs even if you _don't have TCP/IP whatsoever_, NBTs otherwise, but they will delay the boot process by about a minute or so.
Yes, before editing. All the other RAW editors I've seen, including the other FOSS editor RawTherapee, will automatically adjust the sliders to match the embedded preview JPEG. DarkTable doesn't do this, all my RAWs load in looking really strange.
For anyone unfamiliar with the mighty malignancy of Graft, Greed, Lies, and Politics which is the America's federal farm programs - this is penny-ante stuff.

Orthogonal to that - it would be nice if America's states actually grew some vestigial semblance of a spine, and told the Feds where to shove it on a few of their worst abuses of "Constitution? Never hear of it." judicial overreach.
> The SEC's position is simple: the same rules apply to crypto as to other financial products.

If you only reference the SEC's own press releases, you are going to miss the nuance here.

The SEC on its own doesn't get to decide when and how existing securities law applies to cryptocurrencies. Absent a settlement, any action undertaken by the SEC must be decided by a federal court.

Importantly, the SEC has been losing in court. For instance, the SEC, which had been blocking a spot Bitcoin ETF, was told in unequivocal terms by the DC Court of Appeals that its reasons for not allowing the ETF to issue were completely unsound. More pertinent to the question of enforcement: another federal court recently found that exchange-traded Ripple XRP tokens are not securities, with the implication that the SEC does not have jurisdiction to regulate the trading of Ripple XRP tokens on exchanges. If you extrapolate this finding to other cryptocurrencies, the SEC cases against Kraken and Coinbase are on shaky ground.

The fact that the SEC can list so many victories on its website is more a function of how costly it is to fight the SEC in court, rather than being a function of whether the SEC is right in all of its assertions.

There have been too many cases of fraud in the crypto industry, and it's good that the SEC has pursued enforcement against them. There are cases, however, where SEC has gone too far, and continues to go too far—especially in light of the fact that the SEC refuses to set forth clear criteria as to which crypto tokens it considers securities, and which crypto tokens it does not consider securities.

Now that the SEC is going after larger players, we are starting so see more cases actually go to court. If the trend continues, one or more of these cases will end up before the Supreme Court, and we will find out what the actual law is in the United States with regards to which crypto tokens are securities and which ones are not, and whether the SEC does in fact have any jurisdiction at all over the crypto exchanges.

You should not be surprised if after everything is said and done—after we have a Supreme Court opinion—crypto is in fact a special case under US securities law, at least with regards to some tokens.

You should also not be surprised if some of the cases in the list that you reference lose their legal support once the law is clarified by the Supreme Court. In hindsight, some of these SEC enforcement actions may be seen as unfair and unjust.
No. Because if the automobile stopped existing, you'd go back to a horse and carriage. They did compete.

If Twitter implodes, people go to Threads/Mastodon/etc. They don't go to the NYT.
Eliezer made early predictions that we would solve the protein folding problem when effectively everyone else said we either wouldn't solve it or it was way off. If I remember right he was making those claims around 2005 or so and predicting wed have it solved in something like 30 years. We solved it in 2017.
Well, the financial system exists because it provides services that are desired. From what I understand there's really no way to offer those same services purely in the blockchain, except for some imitations that have their own equally big problems.
Virology poses a far greater threat to the world than AI
Once you start buying goods and services in the real world, then the whole “trustless” part of crypto becomes useless.

How is crypto going to ensure the landscaper actually cuts my grass. I have to have some measure of trust and there has to be infrastructure to resolve disputes and try to make people whole. Once you have that, you are in many ways back at fiat currency.
If research is not worth replicating, then how could it be anything but a useless contribution meant only to bolster someone’s publish or perish career?

It just seems that the entire scientific publishing industry is there to support a jobs and prestige program. Any science is just a side effect that somehow justifies the whole racket, from NSF budget to postdoc dinner table.
Especially considering the alternative people are coming from is a loud very noisy machine with lots of moving parts, the fact it makes any sounds is probably not a big deal in the sum of things. Maybe eventually as everyone is in EVs this will be something people notice/care about in a competitive product way and you could or try to eliminate or shape the sounds to be more pleasing beyond. It’d probably make iteration more expensive if it became a requirement.

Most of the time they operate with lots of ambient noise of the tires on the road and outside the car which probably makes a lot of these barely audible or noticeable.
If people go to Twitter for their acute information needs instead of newyorktimes.com, then they most definitely are competitors.

What you're doing is containing NYT in a niche category of "information for people who believe journalists product high quality information". In this niche, your point would stand true; someone who believes legacy journalism produces accurate and unbiased information is unlikely to even consider twitter.

For the larger mass, its simply not true, and the above niche market is a constantly shrinking one.
How They Stopped Work at the Raytheon Facility
OpenAI's origins explain the Sam Altman drama
I had no idea that Harrison's clocks were so complex. His obsession with friction and changing conditions was clearly necessary, in retrospect, but WOW. The extensive use of "anti-friction" wheels, and even portions of a wheel, is very cleaver, but at some point the things look like he's trying to win the clockmakers version of an Obfuscated C contest[1].

No wonder the Longitude Board gave him such grief. It must have seemed like he was deliberately trying to hide secrets from them. Unless you understood how important friction and temperature were in causing the drift of clocks at that time, it would have all seemed like unnecessary complexity.

[1] https://ioccc.org/
How hard is to get a second implementation of the same method? Are the weight in a saparate file that can be copied?
It's articles like these that make things more confusing for folks who are learning about auth/session security. It's obvious the author has developed strong convictions without really understanding the subject.

I can't make it past the first sentence:

> ...utilize JSON Web tokens (JWTs) for session handling instead of cookies.

One has nothing to do with the other. You can use a jwt and cookies. You can use a db session and use a jwt and not use cookies. Etc etc
It's more complicated than this. The conversion of vitamin A (carotenoids) to ATRA is highly regulated by various enzymes, and giving ATRA directly will bypass the enzymes and result in much higher doses than would normally be achieved.
I've used bash for the last 10 years but never read the man page, probably never even opened it once. Is there some nugget of knowledge that I've missed out on by learning it entirely from Google searches and Stack Exchange?
Something I haven’t seen ever answered? Why push this responsibility on consumers and down-stream waste management?

Why not start at the end-product and manufacturing? Most of my trash is food or packaging.

Why not reassign the packaging cost back to manufacturers?, rather than making it a cost born by consumers?
My choice as well. I like the colors my camera puts out mostly, so I only really need to make a few adjustments here and there. DarkTable doesn't even conform the RAW to the preview JPEG, so I end up wasting a bunch of time just getting the RAW to look normal in the first place. RawTherapee also seemed far more intuitive to figure out.
When people meet you they try and group you by asking where you studied etc similarly to where you worked.
Not strictly true: it only needs to matter not enough at the time. But, yes, arguably a fair amount of publications are largely irrelevant beyond a few people.

Societies fund many things for many reasons, not sure science is worth singling out here.
Are you saying tokens can't be opaque?
Wait I thought he was an anti-Semite that is why everyone hates him and why the advertisers left

Now we have to hate him because he is banning anti-Semites

I am soo confused, it is almost like narrative changes based on the time of day and it really has nothing to with Elon at all, but about control of narrative
Yes, but many of them have - like Blender or Linux (the kernel) - a team of professional "core" developers.
You're saying if one car company fails people will use another car company instead of going back to the horse and carriage

I'd agree with you on that
Actually, if you truly, really want to understand Bash by my personal arbitrary standard, then you must be able to produce the entire source code from memory, because that is the real book to rule them all. Sure, you might be able to navigate your everyday tasks perfectly, but that's not what matters now is it?
> whoever gets you that information faster wins

That's just not how it works.

Most people are more interested in accuracy, context, analysis, and trustworthiness.

Sure, papers very occasionally advertise that they were the first to break a story, but this is a minuscule proportion of everything they publish, and it's not the kind of thing that people switch subscriptions over.

If you're a day trader of stocks then speed is king. But for nearly everyone else, it's not the main metric.
There are short aliases for the most used Cmdlets and tab completion takes care of the rest. Type "Get-Process -" and then press CTRL-Space for a list of all arguments. That works with any Cmdlet. Impossible in bash. PowerShell is one of the best ideas to ever come out of Microsoft.
I would recommend against anyone using PixiJS. From a code perspective it feels dated and inconsistent. It can be very difficult finding correct information for the latest version, and you will very easily hit performance problems if you want to create a full screen game. You will need to apply the bitmap caching feature to yield best performance, and to me it seemed riddled with rendering and interaction bugs, or at the very least highly unintuitive behaviour from its usage. I didn’t discover these problems until I was too far into development of my game.
Please don’t Reddit my HN
meh, sounds like Netflix just funded his manic episodes, nothing much to see here
I use mushroom, but these generalized parametric masks look super useful!

That said, Lightroom now let's you mask the sky with a single click.
Huawei, 5G, and the Man Who Conquered Noise (2020)
About 80mb for the city level one
No, you can’t even compare that because the information isn’t packetized. Again, we don’t see in pixels so you can’t just consider sensory input in that manner.
While true, I think the point is a mismatch between MS business strategy (marketing MAUI and the next big thing and officially supported) while not properly staffing. As an end user, you might make tech decisions precisely becuase of the market cap, assuming support and proper implementation.
This fundamentally is the biggest issue with MAUI, no one can trust its not just marketing and going to be dropped...
Oof that was DMCA sniped before I could read it.

While we are at it, it's time for a decentralized git ledger!
What we're seeing here is one embittered ex-developer spending time/effort saying toxic things about their former collaborators in a public forum. At the same time the former developer is making a claim to such radical competence that they can somehow keep an open source project of considerable scope together -- one which until now was coded by generally at least half a dozen committed authors at any given time. The darktable project was originated by some quite bright folks. Others have cycled in/out over the years. Generally without too much drama. It's too bad to be giving so much attention to divisive claims.
Presumably they mean session cookies.
Back when I watched more F1 racing they had a musical performance where they used the telematic systems of some cars, with their high revving motors, to play notes ie the telematics selectively. I couldn't readily find a reference but remember the event.
Ya'know, i still haven't seen much on the modern improvements in hemp retting. Seems like that shoulda been startup bait by now.

At least they havent invited DEA, FDA, and ATF into the regulation party yet.
This isn’t the correct path to learn the basics of deep learning. Take Andrew Ngs Intro to Machine Learning and Deep Learning Coursera classes. I also hear Deep Learning by Goodfellow and company is pretty good too, although I haven’t read it myself.

If you revisit all of a standard Calculus or Linear Algebra curriculum you will WASTE time. Learn the relevant math taught in the ai courses or the beginning chapters of deep learning books, not the irrelevant 90% of each introductory course. I say this as someone who actually used to build neural networks from scratch around 10 years ago and lost interest.
Oh, definitely, but I’m not sure how any of the other cgroups isolation features have anything to do with the massive bloated filesystems that often ends up stuffed into containers. Like… I’m pretty sure I could take the old process of building a tiny self-contained Apache+mod_php filesystem and wrap it up in a Docker container to get the rest of the cgroup magic, but no one does it this way.
Can’t be used when embedding on third party sites though.
Unless you're stealing electricity or computing of course.
When I was in Uni I got a remote side gig developing some software. I spent my whole first paycheck on a 30" Cinema Display, replacing a rig of 3 hand-me-down CRTs. Never regretted it for a second, that thing was pure luxury.
No. Don't tell me what to do
If you are talking about the desert of the American Southwest, sounds like a tale (whether real or made up) about hantavirus.
I always thought it was related to Industrial Revolution coming to Germany.

There was even iron works and locomotive factory in central Berlin during that time.
The area was aptly nicknamed "Feuerland".

A bit further north there was an extremely densely populated residential neighbourhood. Factory workers were living there in terrible conditions. One building (5 floors) had over a thousand tenants. Usually there was only one bathroom for the whole floor. And there was no hot water.

Crime and pollution was a huge problem. The architecture was great, at least compared to post-war times, but life in the city was quite crap.
I'm curious: are there any advertisers that actually thrive in a situation like this?

I.e., where the lack of reputability is actually a benefit for their business / advertising goals?
The new teams is react + webview see:

https://techcommunity.microsoft.com/t5/microsoft-teams-blog/...

This to me was the biggest strike against MAUI. Teams team recently decided to switch tech stacks to address poor desktop performance, and explicitly didn't pick MAUI.
Chrome shows each active tab's memory usage
ATRA he found an organ meats like the liver.

But when not eat healthier in the meantime?

Listen, it’s better to prevent cancer than to have to take some special metabolite drug of vitamin A for a gazillion dollars to cure it, isn’t it?
yes true. Maybe the issue is not intelligence but the voting
Not a valid comparison.

Imagine, if you will, a world with no income tax, no sales tax, because those things were very difficult (if not impossible) to reliably know. Instead what you could know is real estate ownership, because that was tracked by the government. Then you also had a new country that was frustrated with taxation without representation. So you form those who represent the country as those who pay taxes.

The availability of land in those days it was easy enough for anyone who wanted to get it. It was also a way to turn a citizen in to a tax payer. Equating this to IQ is similar in the same way that ice cubes and electrical arcs are the same.
Then why do people keep sending JWTs with only session tokens, which on the backend they treat like session cookies?
Real intelligence will be knowledge that voting is for suckers and the world is run by a congress where the dominant parties are the illuminati and lizard people. Now if an intelligence can determine and conduct the sacred ritual to join the voting pool then we might onto something. But the true test will be when the intelligence again avoids the suckers game and that the world is actually...
For more context, Eliezer does himself a disservice focusing so hard on examples of how things could go horribly wrong but I haven't heard any compelling arguments against his core points.

From everything I've seen from him, his concerns revolve around (1) a lack of a bounding function for the development of AI (2) a view that the alignment problem is unsolvable and (3) the risk that we won't recognize an AI was developed until it is sufficiently more intelligent than us to pose a fundamental risk.
Several forms of "census suffrage" exist.

https://en.wikipedia.org/wiki/Householder_Franchise (Check the other languages because they are more complete and better document the various forms).
In case you're referring to the Apple thing—umm, ya they can. They have the NoDataCollected checkmark designation in the AppStore's Privacy Nutrition Labels. Anything they make is offefed/made 3rd party also and is therefore evidence they could have collected no data but consciously choose to design things in such a was that they are being disingenuous when they say they only collect the absolute minimum amount of data required for functionality