skysight-inc/HackerNews huggingface dataset:
Genomics doesn't merely have massive potential, it's the backbone of research in cancer, even if the diagnostics are slimmed down to simple PCR tests or to even antibody staining on a slide, or to assigning drugs.

In some of the big cancers, sequencing is even a primary diagnostic:

* breast cancer: gene expression signatures are standard for determining the necessity of chemo

* colon: blood based sequencing for KRAS mutation is extremely common

* lung: matching kinase inhibitors to EGFR mutations is essential for therapy

* all solid tumors: tumor mutation burden is a companion diagnostic for the major immune checkpoint therapies that have revolutionized treatment over the past decade.

I know of almost no cancer that has not had massive changes in treatment, due to accelerated research possibly only through extensive use of genomics.
I think the comment is about the equivalence, not about being ready to perform the real transaction.
Sam Altman is a typical fast-growth guy and this is the opportunity of a lifetime to cement himself in the pantheon of high growth tech gods — Jobs, Zuckerberg, Bezos, Musk, Hoffman, etc.

But aw shucks it’s a terrible fit actually, because this company has a non-profit, idealistic mission. In the face of unprecedented high demand, Sam Altman is like fuck the nonprofit hippie shit, let’s launch this thing into outer space. Let’s build fast and ship too many products too early, use investor money to give discounts and build moats, let’s go for regulatory capture! It’s the opportunity of a lifetime guys!

But the board is like nah, fuck that tiring ‘ship broken shit’ tech bro shit, let’s stick to our vision. This is too serious and important to treat it like a fucking Airbnb or Coinbase.
I survive the situation unconditionally.
I continue my life successfully and happily.
At a senior enough level it's public knowledge.

A lot of sub-industries are also "where everyone knows your name" places. I used to be an IT industry analyst (a couple of the large firms in which were known--at least at the time--for being pretty hard-core on non-competes) and pretty much everyone knew what firms other people in their space worked for. You could never have gone to a different firm and had your prior employer not know.
They have tens of billions of dollars they raised. Microsoft can’t make them spend even 10% of that on legal fees. Also why would Microsoft do that?

That just isn’t how the legal system works. You can sue a small business into bankruptcy because a few million in legal fees is enough.
The copilot era takes flight at Microsoft Ignite 2023 – SiliconANGLE
Why Do Some People Can't Remember Faces?
> a descriptive reason for why the value is nil.

Result<T,E> does this. I forget exactly why Result is actually different from, and in fact superior to, `func foo() (*T, error)` but IIRC it has to do with function composition and concrete vs generic types.
Paying the bills will be a great start for sure :-) but I'm worried that I might be too jaded to find what I might have considered a satisfying career even 5 years back. Like someone else said, no one will remember my performance contributions to some codebase that'll get deprecated long after I'm gone, and I think something about satisfaction in my career depends heavily on what will be remembered and what will be important. Gonna keep chugging away on coding exercises and tighten up my resume, and go from there; hopefully I can find something not too oppressive that allows me to find satisfaction in personal work.

Thanks for sharing your perspective. I'm glad I'm not alone in reaching a point like this in my professional work.
Because it was in France at the hands of a french national
I was hoping that might be the case, but it’s sounding more and more like this was just pure politics.
If Steve Jobs didn't have Woz, or if the Apple 1 or 2 flopped, Steve Jobs would have gone on to sell something else - medical supplies, timeshares, or who knows what and maybe he'd be famous in another industry, but not necessarily attaining a reality distortion field. If Apple flopped early, maybe he would have stayed with selling computers, for another company but he wouldn't be elevated to the status he was, because he had Woz's contribution and had total marketing control over it. If he had to work for another company in sales, Steve Jobs would be reprimanded and fired for his toxic attitudes. There is probably an alternate universe where Steve Jobs is a nobody. The reality is that he got very, very lucky in this universe.
I decompiled Apple TV's Android app when it first launched, and was surprised by how well made it was. Rather than rely on a WebView to parse markup and display a GUI as most other major media apps do, it integrated NodeJS for scripting, a native XML parsing library, and then drew the entire UI directly to the display as if it was a full screen video game. This allowed it to have smooth, consistent animations on hardware which choked on Chromium's bloated resource needs. It also let Apple have a cross platform UX without needing to rely on any of Android's native UI controls.

I was pretty astounded by its elegance, simplicity and power. Apple was able to build off the work they had already done for Apple TV and the end result was a compact and relatively straightforward application. I bet it's even easier to maintain than apps which use standard Android dev tools and libraries.
MS may not have any legal sway over the non-profit, but I wouldn't be surprised that in most cases they'd at least be consulted or given a heads-up on something like this, since it affects the for-profit bits of the org as well.
If you buy forest or agricultural land you are pretty safe. The worst thing that can happen in civilized places is that a big entity forcefully buys it away from you for "reasons" and you don't get as much profit as you would like, but nonetheless then you can just buy more land somewhere else. Owning developed land is just a liability in many places since you've got to pay taxes and all kind of annual fees. It's business at that point and not just owning land (your business instincts don't have to be nearly as good when dealing with forest and agricultural land).
If this is true, I think it’s a mistake that they fail to publish a clear letter saying this in plain terms. The sooner the better.
After Silicon Valley gave everyone terrible gig jobs and disastrous social media that amplified polarization then ended privacy to sell ads, does anyone really think anything they produce is a “benefit to society”?

Like how much damage do they have to do in the name of efficiency, profit, “the future” before the “benefit to society” meme dies?
I am also not a stranger to board positions. However, I have never been on the board of a non-profit that is developing technology with genuinely deep, and as-of-now unknown, implications for the status quo of the global economy and - at least as the OpenAI board clearly believes - the literal future and safety of humanity. I haven’t been on a board where a semi-idealist engineer board member has played a (if not _the_) pivotal role in arguably the most significant technical development in recent decades, and who maintains ideals and opinions completely orthogonal to the CEO’s.

Yes, generalizing is how we reason, because it lets us strip away information that is not relevant in most scenarios and reduces complexity and depth without losing much in most cases. My point is, this is not a scenario that fits in the set of “most cases.” This is actually probably one of the most unique and corner-casey example of board dynamics in tech. Adherence to generalizations without considering applicability and corner cases doesn’t make sense.
>However, a non-profit board has a primary responsibility to its charter and mission - which doesn't compute for those with fiduciary-duty-instincts

Exactly. The tricky part is that board started a second for profit company with VC investors who are co-owners. This has potential for messy conflicts of interest if there is disagreement about how to run the co-venture, and each party has contractual obligations to each other.
I agree with what you've written here but would add the caveat that it's also rather terrible to be in a position where somehow "shepherding responsible AGI" is falling to these self-appointed arbiters. They strike me as woefully biased and ideological and I do not trust them. While I trust Altman even less, there's nothing I've read about Sutskever that makes me think I want him or the people who think like him around him having this kind of power.

But this is where we've come to as a society. I don't think it's a good place.
Okay, the second episode is out. It's about how to expand the emotional expressiveness of GPTs.

I improved the audio and I encoded it using MP3, so hopefully that solves any problems with playback. This one also has a transcript.

Check it out at https://aimeetsproductivity.podbean.com/e/how-to-expand-the-...
The OP is from the International Committee of the Red Cross, which is the/a authoritative source. Also, compliments to their design, which makes a complex, somewhat intimidating topic quite approachable.

For some expert analysis for the current issue, the war in Gaza, see this post in a blog by leading experts:

https://www.justsecurity.org/89489/expert-guidance-law-of-ar...
Plenty of Go commentary in this thread but can I just say I'm glad to have learned about nilness? Suffered through a few nil pointer dereferences after deploying and having this analyser enabled in gopls (off by default for me at least) is a nice change.

Tested via vim and looks good!
It’s only down to where it was last week. That’s not a swan dive.
So my understanding from reading the drama the past day is Sam Altman was fired from OpenAI due to being too inclined to 'move fast and break things' by commercializing OpenAI technology, with Greg Brockman (cofounder/board member/close friend/ally) choosing to resign in solidarity. The board coup was organized by cofounder/Chief Scientist Ilya Sutskever who apparently wants OpenAI's original slow moving safety vision.

It's speculated Sam Altman and Greg Brockman may start a new AI company.

So now seems like a good time to mention a few very high-level points in case they read it:

1. I love Sam Altman's ship early and often inclinations, even if that apparently got him fired. OpenAI was such a breath of fresh air compared to sclerotic companies like Google that can invent the Transformer architecture yet be organizationally incapable of shipping ChatGPT-level tools for years due to overly conservative safety concerns

2. I hate OpenAI (or Sam Altman's?) apparently puritanical inclination to anything considered Not Safe For Work, especially for paid API usage. Why not allow people to build and sell virtual partner chat bots with explicit NSFW content?

3. I dislike his apparent inclination to build a regulatory moat to block others from developing advanced AI -- it's easy to interpret this as purely in the self-interest of OpenAI shareholders

Without Sam Altman's inclination to move fast I imagine OpenAI may become slow, sclerotic and less capable of shipping early, like what Google has become.

Good luck Sam, and keep on shipping!
Then please pinpoint some problematic ones, so that not every reader has to delve into pages to continue the discussion.
> What am I missing? It's all so strange.

That they weren't concerned about day-to-day operations, employee morale, product roadmaps or any of that boring stuff. They were operating on the precarious calculus of their "friendships" and commitments.

They had to act fast. It is possible, if Altman or Brockman had more chance to talk to board people, they could have changed at least one member's mind.
Strangely, I am always adding credits and then using the API and Dall-E since the beginning.

Also, my MidJourney subscription is fixed pre-paid(i.e. they deduct the bill for next month at start of the month anyways).

Honestly, I prefer the pre-paid and credit system in general, no lock-in for when I won't be using something for a while and no risk of racking up huge bills and getting surprises at the end of the month.
Yo OP cool you commented here! At the very least I think your website is pretty good - and I like the prism logo. Being able to write up a post and have it get international eyes (via HN) is more than many people ever try to accomplish.

I often think of coding like making music: you don't need to be an expert at an instrument to make nice music - so much to the point where "making music" and "playing an instrument" can be considered very different things.
The phone is right for all the purposes; it's not what it can do -- it's when it can do those things.
Gaza was not a ghetto by any stretch of the imagination. Check their HDI before the war. It exceeds that of many countries.

If Gaza was a ghetto, from where does Hamas get the money to stockpile vast amounts of arms? Couldn't that money have been used to improve living conditions.

Gaza had areas that were described as "wealthy". I wonder how that is possible in a "ghetto"
I think MSFT has full access to the underlying tech, not just a strategic partnership with OpenAI. I think their AI/LLM offerings have a future even in a future without OpenAI.
They created the for-profit subsidiary for the express purpose of raising more investments.
Hopefully MSFT just goes off and does their own thing. I find this holier-than-thou "we're non profit and we're going to save the world how we see fit" irritating. Talking about AGI like it's an animal ready to pounce when we're quite obviously nowhere near it. Machine learning development has been sluggish for the longest time and the moment it was commercialised, there was an explosion in possibilities and development.

"AI safety" is a euphemism for "aligns with our interests." "Roko's basilisk" is nonsense science fiction babble.
Do you even understand how much work is necessary to put in, to influence a whole industry massively and with the biggest players?
DD learned from NR's mistakes. But they're both expensive now.
ChuckM/CarEarthquakePrep: The "go bag" in my car to be ready for earthquakes
My favorite example of this is the Third Imperial Faberge egg. It was made in 1887, seized by the Soviets during the Russian Revolution, and apparently sold abroad. It ended up in a flea market in the US in 2004, when a scrap dealer bought it without knowing what it was. He wasn't able to sell it for the price he wanted, so he kept it in his kitchen as decoration for several years. In 2012, he googled around and found an article about the missing egg, realized he probably had it, contacted a jeweler and Faberge expert, who flew out and found the egg sitting next to some cupcakes on the guy's kitchen counter: https://www.telegraph.co.uk/multimedia/archive/02855/egg_285....

This Telegraph article has more details: https://www.telegraph.co.uk/culture/art/art-news/10706025/Th...
Shooting from the hip with a shotgun ... is performant, but it often wounds innocent bystanders.
> I think they want to be shepherding responsible AGI before someone else does so irresponsibly.

Is this a thing? This would be like Switzerland in WWII doing nuclear weapons research to try and get there before the Nazis.

Would that make any difference whatsoever to the Nazis timeframe? No.

I fail to see how the presence of "ethical" AI researchers would slow down in the slightest the bad actors who are certainly out there.
ooh, lanes... the Microsoft internal buzz-word that got out of fashion a couple of years ago is making a comeback outside of Microsoft....
Do you disagree with my claim that GPT-4 can perform some sort of basic reasoning about puzzles that aren't in it's training data?
Expire !? For example, let's think about a solid basic land reform, and every owner now has to pay 5% of the immobile-value on it, as an annually tax.

And after twenty years i don't have paid the debt for an apartment or house, two-times?

But, sure so americans try to sell us houses builded from; chipboard, insulating wool, plasterboard and roofing cardboard?

i am questioning this... in terms of: "money was to last longer than the expiring and perishable things" and "The real estate bubble created by low interest rates"

Cos for me it seem that it ignored grief and "people" for -to be objective something the OP named "interest", i won't sound offending but it seem to be a mistake (both..all three...)

regards...

edited: sry "alittlebut" i mistaken you for the op p-:
It is probably because even if the signal is within a certain band the band still has a frequency legenth longer than a simple decimal point. Channels operate in a range of frequency for example. Even if a device 5g and it needs to connect to a tower it will do its best to replicate the upstream / downstream signal with little noise as possible. However the noise is the difference between the devices, they are distinct and this is how they are probably determining the device.

Also radio waves do not just go away. We are probably incredibly loud planet to any radio wave sensitive alien/creature.
So why the spectacle? Why the melodramatic press release and thoughtless communication with investors?

I will not shed a tear for Altman or Microsoft, but this fantastic Friday massacre, don't seem to line up with cause.
I am testing Frigate for a couple months now. It is a very ambitious project and I would love to see it succeed.

Here are the observations:

* You don’t actually need hardware decoding or a Coral, but they do help. You will of course need to provision more CPU horse-power for NVR.
* Motion detection uses the usual implementation from OpenCV. Unfortunately this algorithm is not very good in my experience. Many things I would consider as motion are missed (false negative), many things I would not consider motion are being detected (false positive). These factors mean that one is tempted to go ham on masking to filter out false positives, which then leads to further false negatives. I’m genuinely surprised the motion algorithm that’s implemented in OpenCV is still the state of art of what’s available openly.
* Object detection is somewhat knee-capped by the models available publicly. They are not very good either. Frigate has built its behaviour around these models with an assumption that these models are largely pretty accurate, which in my experience has ended up with quite a few missed recordings for important events, which led me to switch to create recordings based on motion (I’m not in a very densely populated area and reviewing the recordings isn’t too onerous.)
* Support for coral is… shaky at best. There are some indications that the production of these devices has largely stopped (and finding them to purchase is hard and expensive,) and maintenance of the drivers and libraries to interface with coral seems to be minimal or non-existent to the point where some Linux distributions have started dropping the relevant packages from their repositories. On the upside, running these models on the CPU isn’t that expensive, especially considering that the models are invoked very sparingly.

I’m currently thinking of moving over to continuous recording, perhaps trying out moonfire-nvr or mayhaps handwriting a gstreamer pipeline. Simple software -> fewer failure modes.

(NB: I worked at a computer vision startup in the past, my views are naturally influenced by that experience.)
I don't really disagree in this specific case. Although there's also lifestyle creep--perhaps especially in the case of living in NYC.
Seriously? The Louvre is literally made of Greek (two of the 3 most visited art pieces are Greek), Italian and Egyptian art.

That’s it. There is very little French artistry. The French masters came a bit later and have their own museum which I wish to visit one day.

Doesn’t matter _how_ it only matters that the French pay attention. Italy doesn’t need one painting, the entire country is stunning and financially speaking “suffering” from tourism. I mean it is a huge source of income, but they lost the “locals quality of life” balance with tourism long time ago.
I think there needs to be more studies in the field of nanoplastics. They are nearly everywhere and all man made.
I gave it the three lightbulbs in a closet riddle.

https://puzzles.nigelcoldwell.co.uk/seven.htm

The key complication is "once you've opened the door, you may no longer touch a switch." It gets this. There are many examples of it written out on the web. When I give it a variation and say "you can open the door to look at the bulbs and use the switches all you want" and it is absolutely unable to understand this. To a human it's simple: look at the bulbs and flick the switches. It kept giving me answers about using a special lens to examine the bulbs, using something to detect heat. I explained it in many ways and tried several times. I was paying for GPT-4 at the time as well.

I would not consider this thinking. It's unable to make this simple abstraction from its training data. I think 4 looks better than 3 simply because it's got more data, but we're reaching diminishing returns on that, as has been stated.
Yes but they want more. Authorities can't print endlessly, inflation would get too bad and apart from the danger of economic collapse, ordinary people do notice when the purchasing power of their money rapidly depreciates, even when they don't fully understand why. In comes CBDC and the realistic ability to make this "free money" stamp idea a thing at scale. They could give the tokens an expiry date as well, Chinese authorities have proposed such a thing.* Or void certain ones while leaving others untouched. For example if you were to take part in an illegal trucker protest, poof go your savings.

*https://www.econ.iastate.edu/ask-an-economist/why-would-chin...
This is the most on point comment I’ve seen in the dozen threads on this topic.

I think the reason so many people on HN can’t come to this obvious conclusion is they share the same sociopathic Silicon Valley worldview he does.
I can't help but think of the similarities between Frankenstein's Monster and AI. Both are human-created intelligences that learn to understand us by observing our behavior and writings.
Note that at this point in time it is economics, not yield-per-area that dominate any solar cell installation so a new cell doesn't necessarily have to be high yield, it has to be better when you compute total power generated for a given $ invested over the lifetime of the cell. That's pretty much all that matters, everything is just a distraction unless you are severely space constrained a couple of percent more or less isn't going to make a huge difference, and cost savings on existing processes have now compounded to the point that people are more and more looking at the price of inverters and installation as important factors. That's also why you see the push for transformerless inverters (those are bulky and costly so they affect both inverter cost and installation/shipping).

I did a pretty big solar installation over the last two years and I decided to go for quality panels because the glass-glass sandwich panels have a much better economic picture than the glass-plastic ones even though they are more expensive up front.
Elon Musk doesn’t have 4-5% of the federal budget and SpaceX is well on their way to doing it. I agree with the parent, there’s something else going on, either with society, or our government.
Ahh yes because bad people are sub human and don’t matter. Calling out classes of people subhuman has world out so well in the past. /s
Green of course? Anything else would be highly unusual and a normal reader would expect it to be called out.
That the board is not very good at their job. A more experienced board would have been more professional and less dramatic, but we're in the stupidest timeline.
Just a nitpick. "Fiduciary" doesn't mean "money", it means an entity which is legally bound to the best interests of the other party. Non-profit boards and board members have fiduciary duties.
Why on GitHub?