skysight-inc/HackerNews huggingface dataset:
> Presuming “we” is the companies that own the current patent, what does this have to do with the older molecule’s patent that is expiring?

"Evergreening" is a very common practice among pharmaceutical companies. In its purest form, it looks like this:

* About 10 years after a drug has been approved, they will seek approval for a replacement version which is very similar, but different enough to qualify for a different patent.

* Then they have a few years to get everyone onto the new drug, claiming that the new one is safer, or more effective, or (in some cases) that the original one is horribly dangerous or has abuse potential which is somehow solved with the new drug[0].

* Around 15 years after the first drug was first approved, once enough people are on the second drug, they'll withdraw the first one from the market entirely, forcing everyone still using the first drug to switch to the second.

* Then, when the patent for the first drug expires (year 17), there's "no market" for it, because nobody is currently prescribed that drug, so no manufacturers will bother producing any generic versions of it.

Rinse and repeat.

[0] Heroin™ was one of the first examples of this: it was developed and marketed by Bayer as a "less addictive" version of morphine.
Or, it assumes that the only reason they didn’t act on this inclination is due to the fear of punishment. Which omits the possibility that they don’t do it because they know it’s wrong.

Edit: typo
Goodness, are you not familiar with the phrase "correlation does not imply causation"?

There are ways to establish causal relationships, the gold standard of which is to conduct a double-blind controlled trial.

To claim as you have that a correlational study establishes a causal relationship is deeply misguided, irrespective of whether or not it is peer-reviewed.
Depends on the entry. For most technical entries I see it as a quick summary you google for and it's fine (if not sometimes a bit outdated on modern practices. But that's fine, it's an encyclopedia, not documentation). It tends to be pretty good as a spingboard to other stuff.

For politicized stuff I see it no differently than any other aggregator like Reddit or Hacker News. get a quick feel from the post and comments (yeah I even read the editor comments), look at several sources and get a feel for their bias. Then try to form my own view based on that. I see bias/editorialization there because I see it in every single person's POV. That's just life and why the number of sources I'd ever take wholesale are ones I can count on onehand.

Wikipedia is definitely very weak at developing stories, where you'll really see the back and forth happen underneath.
Quite the opposite if you see my other comments, I think you may have misread what I said here. This statement is clearly a problem imo, its usage of political slogans makes it more of a declaration of political allegiance rather than actually being about inclusivity.
Digital democracy or IT anarchy? Gartner flags the low-code revolution
World of Warcraft used Lua, but Warcraft III used a proprietary language called JASS.
> No one reads them. It's just some stupid long-tailed distribution where three of these absolutely useless fucking things gets read a few times a day (by someone that probably doesn't do anything with the information) and the rest of them don't get read at all.

My first job out of college was on a cargo logistics team where we were tracking multiple pieces of very, very expensive cargo that had to be packed in a certain way while in transit to their destination (which rhymes with "Blinternational Blace Blation"). The job wasn't terribly difficult; our node in the planning chain was a database with about 80,000 records with maybe 110 properties per record, and most were managed by the system. We were actively tracking 5-8000 at any given time.

There were tons of issues in the overall cargo logistics process, because at each "node" in the process, no one (hardware owners, hardware coordinators, packing technicians) really cared about data sanitation. This was my first job, so as I researched the root causes of problems I'd find core design deficiencies, like "Desired Shipment" being a free-text entry field instead of a pick list, or "[Status] = Approved" meaning one thing to one group and a different thing to a different group.

Eventually, I'd grown so competent that I had a list of about 45 checks to do on any individual record, and I was using Power Query to create automatic reports on how many records per shipment were corrupted, incomplete, or otherwise likely to cause issues. I'd get hauled in to various large working forums to explain why processing was taking too long on some $10M microscope and I'd pull out my dashboard and reports to show that the hardware owner hadn't entered in dimensions or mass yet, and that there were 17 more records that had the same deficiency, yadda yadda yadda.

No one ever really did anything with all the work I put together, and every time we suggested something some division would have an elaborate explanation for why they wouldn't possibly sanitize their data or provide it earlier in the process. Last I heard they're paying millions of dollars per year to develop an end-to-end platform to do exactly the same thing I was doing (query multiple databases, compare records, spit out lists of incomplete records). I doubt that expensive database-reading tool will fix the problem either, because it's not even just that "no one reads the reports"; in addition to not reading the reports, they don't know what to do with the insight.
It slows down gastric emptying as one of the primary ways it helps people feel full longer, so there a slew of possible GI side effects (nausea, constipation, diarrhea). In general they are manageable due to being able to adjust dosages to where patients still lose significant weight and minimize the impact of those side effects.
It's not that i think anything is wrong, but isn't it strange there's no jump I see in WFH comments during the pandemic when everyone was doing it
The argument that dockworkers single-handedly is deciding what is allowed to be imported is simply false to begin with. The members of the Transport don't dictate what's allowed to be imported - there's just no-one that's willing to unload cars of this specific brand before the ship has to leave again. There's a difference, as Tesla could try to import them by other means.

So far there's at least five large unions that have already joined or is about to join the strike, as it affects the whole of Sweden. To calculate how many members there are in the unions that are currently involved and actively support these actions you'd have to include mechanics (IF Metall), dockworkers (Transport and Hamnarbetarförbundet), electricians (Elektrikerförbundet), maintenance workers (Kommunal) and postal service employees (SEKO). These five unions amount to about 1M members in total, or 19% of the Swedish workforce, as some of them have members from more than one field.

The pressure will be incrementally increased until Tesla realize that they have the whole nation against them, so you would pretty soon have to include the full 70% of the working population to calculate how many members there are in the unions that's currently involved. The docks is a good place to start but as we've seen today, that was merely a warning shot - as advertised in advance.
Chromecast as well. Everything shall be enshittified.
Because as they clearly demonstrated its not your garage door.
I think a lot of people are just... either epistemologically confused, or unreasonable, or a bit of both.
The use of language like "oldest pyramid in the world" seems a bit misleading as this structure has been built in several layers around a pre-existing volcanic core. As a feat of engineering it is not directly comparable with the Egyptian or Mesoamerican pyramids. It skipped not only the difficult work of building the core, but also potentially the need for architectural planning and large, organized work crews.
Platos cave is also a work of fiction.
As the DRM arms race continue, in the next model the button will be a fingerprint reader. To make sure you're not cheating, you can only use the reader in the precise moment an ad you have to watch will tell you so. Of course, even then you will have to watch the ad till completion before the button really does anything.
What is the gold standard currently? Like phentermine or diethylpropion? Or is it actually Ozempic?
What do you mean by "enforceable"?

If the penalty is something like a user account being banned, sure.

If you mean some sort of criminal or civil liability, not as much.
People worrying about cultural displacement in europe need to crack open a history book and understand the movement of people is just how the world works. Its like the movement of air from different pressure areas. Most spanish people are actually a mix of moors and visigoths, other mediterranean people through history, and even celtic or germanic peoples who by and large displaced some earlier occupant of the iberian pennisula, who displaced some even earlier people, and so on and so forth until we get to whoever displaced the neanderthals. And all of this displacement involved assimilation too. Acting like migration should stop now would be like asking the wind to stop blowing or the tides to stop. Its like a natural law that people will go where theres better opportunities for them.
The downvotes, I guess, are because this is kind of a silly concern. Steamers do rude things all the time, but that’s not a good reason to change the law to prevent everyone from doing the thing that seems rude in that case.
I don't know how to interpret this answer. The nature vs nurture aspect of the alleged gender preference against direct/blunt speech was never even discussed.

It seems to me like people are just letting their own biases shine through. Perhaps the people claiming sexism falsely believe that a higher preference for direct/blunt speech is always superior somehow?
That was a local political purge, not a business one. They also use slave labour to build stadiums, and nobody gives a shit, but the second some visiting CEO gets impressed into a worksite is a red-line they aren't going to be crossing.

Local businesses and politicians have no choice when it comes to working with those animals, foreign businesses absolutely have a choice. That's the difference.
Yeah, tbh, the fact that they allow side loading makes up for this, IMO. I still wouldn't necessarily buy one. I've found that I like the Google TV ecosystem a little better.

But being able to sideloaded whenever needed makes it much better to me than some of the "less intrusive" options.
Like I said, she didn't grasp it fully, so it's hardly even a ripoff.

The only "new" thing she adds is an obsession with thinking rationally, but in a sloppy way that ends up just being nonsense. For someone obsessed with rationality, she never took any time to understand it, e.g. things like Bayesian inference, and reasoning in real life with messy uncertainty and incomplete information. Her type of rationality only works in carefully constructed fake scenarios in books, and ignores both the value of emotions, and the fact that cognitive biases make it a challenge for us to tell apart emotional reasoning from rationality, without practice and specific techniques. She boils it down to a moral choice, when it's actually a skill - a skill she didn't respect or develop in herself. Without these things, "rationality" is usually just a strategy for emotionally manipulating others by making up your own "objective" authority.

Carl Jung is a better example of someone who really understood Nietzsche, and (intentionally and correctly) "ripped off," e.g. borrowed and built upon some of his ideas. He also (unlike Rand) understood that much of our intelligence is connected to our unconscious, and is communicated through emotion... to deny that it to deny most of yourself.
> on a topic you know to be controversial in society

What else could you reasonably expect? Unanimity without discussion?
If, hypothetically, libraries in the US - including in particular the Library of Congress - were to scan and OCR every book, newspaper and magazine they have with copyright protection already expired, would that be enough? Is there some estimate for the size of such dataset?
It's a term in queuing theory: https://en.wikipedia.org/wiki/Backpressure_routing
A monster eddy current is spinning into existence off the coast of Sydney
GPT-4 would be more responsive. They ignore support requests for weeks unless you keep reminding them.
Blocking the mail seems overly aggressive. I don't agree with that tactic.
Thanks for the context :)
> are intuitive to almost every learner

what intuition would a learner rely on to understand the difference between the 1 and 1/2? or 1/2 vs 1/8?
Sounds like spreadsheets only worse.
> Why save it locally when it can trivially be streamed?

If you usually have a network connection, then most of the time streaming is fine. However, not everybody does. About 50% of the time I'm not home, I have little to no service, and even sometimes when I have a strong signal, it will randomly just stop working unless I toggle airplane mode off and on to reforce a handshake with the tower. If we all lived in a big city then sure we could probably make that assumption, but some people live in Wyoming. With local storage I can download high quality FLACs from Bandcamp and get higher quality without having to even think about whether I'll have service. Offline playback of music is a feature the original iPod had!

> Why keep your entire photo and personal movie collection on your portable device which can get lost and broken when you can just connect back home and access even more storage with higher reliability anytime, anywhere?

I would guess most people have more than 100GB in personal photos and videos, so even for the average use case this seems wrong, but especially for people that record much 4K video, you'll run out of space very quickly. Those files can easily get multiple GB in size. If you're on a vacation where you have little or no network connection, you'll have to downgrade your video quality or limit what you record. How is that better? If there were an SD card slot, this is a non-issue because you can bring as many SD cards as you need, and swap them out as they fill up. Can you do that with onboard storage? Then it's not a replacement/obsolescence, it's just a feature removal.

> I don't understand what you mean about "spyware built in" for Bluetooth headphones. All my Bluetooth devices do not have any other kinds of network connectivity, they don't phone home or anything like that. There's no app or anything like that needed for them.

That's great, I'm really happy for you. But some bluetooth headphones do have spyware (especially some of the best ones in some people's opinions). If it requires you to use a special app to pair and/or access features, then it (probably) has spyware in it. Bose is a great example (or at least was, maybe things have changed). With a physical head phone jack, there's no pairing required and there's no way to force you to use their software. That's a hell of a feature IMHO.

That you don't personally have a use case for a headphone jack, doesn't mean it's obsolete. There isn't a replacement for a physical headphone jack, only alternatives with different pros and cons. If that were the criteria, then the M3 macbook would be considered obsolete because I don't personally have a use for it.
According to (second-hand) experience with auditors with respect to open source, they were quite open to considering things like CI, good commit messages etc. are useful when evaluating the development process, and even considered them sufficient (with adequate explanation) towards some of the ISO26262 requirements. However, that was for ASIL B only.
That is exactly what I see most of the time in high quality discourse around current events. People pick the items they want to emphasize or de-emphasize and that is what creates different narratives.
Israel is not exactly known for eschewing the use of torture, historically or currently.

https://www.amnesty.org/en/latest/news/2023/11/israel-opt-ho...
https://archive.is/908kf

and

Non paywalled article: https://finance.yahoo.com/news/housing-market-starting-crack...
Philosophy is mostly a maladaptive male response to childlessness.

OK, OK, perhaps that’s unfair, but it’s surprising how male the discipline of philosophy is, and how many of the big names had no kids.
Ai advancements have my small but positive impacts on things I've done.

But my not so informed opinion is text as an interface is only a small feature of bigger useful products, not the main focus. Instead of learning sql, you can ask a regular question. It feels like inventing the mouse to use with computers.
That works fine with a TV. I bought one knowing that the "smart" features weren't all that great. I tried connecting it to the internet, and it felt more sluggish, although it's a brand new 2023 model. I was able to reset it to factory defaults and it's working well enough for what I bought it for (the image is very good, at least for my needs). For reference, it's a TCL with Google TV.

But the Fire TV TFA talks about... well, the whole point of the thing is to stream internet content. So not connecting it to the internet kinda defeats 90% of the thing's purpose.
>why didn’t their profitability soar

Because their stock buybacks and other executive compensation did.

This is public information.

It’s really weird how we also publicly acknowledge the ability of companies to hide profits, but when it comes to actually discussing corporate greed, in comes the bootlickers to drop their “wHY AReNT PrOFiTS SoArINg ThEN?!?”

We can see where as much as they want us to see is going: a couple people and a couple board members.
Male performance advantage remains even for those males who choose to lower their testosterone levels; they retain muscle mass and strength above women, and their overall skeletal structure remains intact too: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846503

In fact, the difference between male and female athletic performance is so stark that even the most elite female athletes are at a disadvantage compared to teenage boys: https://boysvswomen.com
Agreed. My mom was complaining that she had a blood test scheduled for noon where she had to fast before the test. I was confused as to what she was upset about, and then finally realized that she didn't think she would be able to fast until noon. I'd been doing IF for so many years that this problem didn't even occur to me. Like, you can't go until noon without eating? :-)
As far as I know, AI hasn’t succeeded in literally blinding anyone: https://mashable.com/article/bored-ape-nfts-vision-loss-apef...

Molly White’s comment at the end is superb.
Just as you must distinguish between philosophers and philosophy professors, you must distinguish between philosophy and academic ersatz. We all know what guides and drives academia. It's not always the love of wisdom (philo + sophis).

Why should metaphysics be a dead end? Given the facts of observation, what must be true of reality so that such facts can obtain? Metaphysics is tacit within the facts, and a metaphysical stance is tacit in one's claims. Everyone here would agree (except in some artificial, dishonest, rarefied moment of academic detachment from reality) that something cannot both be and not be the case. We could not possibly reason about reality otherwise. But why should logic take this position? Logic is concerned with correct reasoning, but reasoning is about reality. So the justification for the logical principle of contradiction can only be found in the metaphysical, that is, in the reality (or being) that we are reasoning about. It must be that reality (being) is such that it cannot both be and not be. It is the only way to maintain the faithfulness of reason to the real. Any attempt to undermine this correspondence undermines the very attempt to undermine this correspondence, as you would would no doubt be reasoning to such a conclusion. Thus we have the first methodological principle of first philosophy, that our conclusions cannot undermine the very means by which we reason to those conclusions. We are condemned to reason, so we better do it well as there is no other alternative, other than doing it poorly. This rules out skepticism and relativism off the bat (and incidentally, this is why even academic philosophers generally do not take these positions seriously). And ethics, of course, entails metaphysical propositions like anything else.

That these are difficult subjects often executed poorly does not mean they are bullshit as such.
> IRC had channel-wide, server-wide blocks available since the olden days, as well as user-to-user blocking. The term "flamewar" is old school from these days where people got hella banned. Forums had trolls that were banned and re-banned, see: the age of the term "sockpuppet".

And you had to really work to get a ban in most forums and IRC channels. You had to really step out of line - and continue stepping out of line.

Cast even a momentary glance at the things people get banned for on Reddit, or used to be banned for on Twitter.

A woman declaring, "Men are not women." is enough to have her Twitter account permanently deactivated. Try telling me that's even remotely close to how things were in the 1990s Internet.
I like it, but I think how easy it is to replace is more important than how easy it is to extend. Otherwise it might end like those massive class hierarchies instead of a function.

For me, pure functions and enforced types do the trick.
I think this is the real value prop of the Apple TV now for many people, particular non technical types or those who just don't want to monkey with networking etc. Usable interface and isolates your TV from the network.

I met someone doing something similar with a PS5 but that seemed awkward.
Yeah so annoying. And very hard to block.
Crypto is still one of the best ways to do foreign exchange even if the ecosystem is run by morally bankrupt hucksters.
a well-developed aesthetic that is used as an informed choice

Wow! I love the way you phrased this, and your post in general. It put into words something I had struggled to express.

For too long, pixel art and other "dead" technologies like Q1 mapmaking were largely treated solely as kitchsy "retro" or "nostalgic" aesthetics and not worthy of study, refinement, and enjoyment in their own rights.
The bulk of AI "projects," yes. As a discipline, no. Just like with the crypto nonsense, a bunch of junk was created and died. The same will happen with AI. What's left after the hype cycle/cash pump will be the things of real value.
The practices you're describing largely seem sensible, but I think they are also beside the point made by the article, namely that Texas seems to emit more gas per unit of production than a neighbor.

> gas doesn't have a ton of value in the Permian basin.

You note this, but the assertion that selling or using the gas to run generators are top preferences for producers seems contradictory, or perhaps a bit oversimplified.

If gas is abundant and has little value, I would expect there would also be little incentive to sell it when it isn't trivially easy to do so, or to store it for later use running compressors or generators. Cheap gas would mean venting or flaring are the least expensive option in more situations.
To be fair, "Israel retaliated with a bombing campaign" doesn't exactly describe the terror inflicted on the citizen population of Gaza either.

Part of high-quality journalism is being precise without emotion or opinion clouding the reporting.