skysight-inc/HackerNews huggingface dataset:
The ritonavir story is super-interesting. It's also interesting how the problem got worked around. Initially, ritonavir had to be shipped as a frozen gel, to slow down the conversion. But this was not optimal at all.

The ultimate solution was hot extrusion: molten ritonavir is dispersed in an inert carrier, and then left to cool. The carrier insulates the droplets from outside contact, so it can't get contaminated with the more stable polymorph.

This idea itself is completely obvious. But like pretty much everything in engineering, it took a decade to perfect the process.

If you have a misfortune to get prescribed Paxlovid for COVID, break a tablet and look at it in a microscope. You'll clearly see the ritonavir droplets embedded inside the carrier material. It's super-cool.

(Ritonavir is used in Paxlovid not because of its antiviral properties, but because it inhibits some liver enzymes, thus slowing down the metabolism of the active ingredient)
On the other hand I got a rash and tried to google diagnose and got in completely wrong whereas the doctor figured it in seconds (shingles). Probably best to try both approaches.
Who says they have to reach Datadog/New Relic scale to "succeed"?
> Most will discover that their 401K, despite maximum contributions, will be insufficient to retire on.

How will that happen when there has been so much growth in the S&P?
Moving itself is probably wouldn’t be so bad if it weren’t as frequent, for instance if maybe moving once after college would be it for most people. That’d still give people time to set down roots.

Instead it’s often necessary to move repeatedly, for reasons varying from going to school to getting a job to finding housing with room for kids to just trying to keep rent from eating up the majority of one’s paycheck.

In my case I’ve moved 9 times in the ~15 years since I turned 20 and it’s very likely I’ll be moving again in the future. It’s been very disruptive for maintaining connections, even with the power of modern communications at my disposal. I’ve more or less grown used to it and am kind of introverted anyway so I’m not depressed but I could see where others might not be so lucky.
Have you ever watched a nature program? 99% of animals are spending 99% of their time trying to survive and reproduce. They aren’t asking themselves “why?” hence the absence of any existential crises.
That is the universal behavior, and it is totally valid for any being capable of knowing this to be depressed about it.
Ah, so the overall economic efficiency improves and then everyone's better off. Wait, what's wrong with that?
The terminal is a UI, but it didn't forbid the development of GUIs and IDEs.
eBPF-based auto-instrumentation outperforms manual instrumentation
Perhaps with something like Kiwix?
I have used it for offline Wikipedia during prolonged travel...

https://wiki.kiwix.org/wiki/Main_Page
In case anyone else convinced themselves that iOS doesn't support the Web Audio API, try turning off silent mode with the physical switch on the side of your phone.
Another issue is that doctors are coming out of school with more student loan debt than ever before, so when it comes time for the older doctors to retire, the younger doctors haven't built up enough personal equity to take over the clinics.

Nobody seems to care about the student loan debt of doctors, because doctors can make a good salary, but student loan debt still has negative consequences down the road such as this.
i am currently using a very rudimentary player that is extremely lightweight, vanilla js, supports basic multi-room (multi-device, i.e. pick a track on your phone and listen to it from the tv) and defaults to repeat 1 mode. I want it to run without issues on old phones so i can just hook one up to the stereo. Considering adding drag and drop so i can listen to local tracks as well

(you clearly need some sort of server to do this, i am using mqtt because that's what i had laying around, but maybe this could be feasible with modern browser features skipping an external server?)
There's a fascinating internet trend named "Bronze Age Shitposting" - clips usually featuring The Epic of Gilgamesh as sung by Peter Pringle and/or Hymn to Ishtar as read by Karl Hecker, inserted into various scenes from movies, series etc.

Sometimes they refer to news in archeology of the related region/era, so I suppose we can expect a clip referring to the story from the article to appear soon.
I'd like to revisit this statement in 10 years, if I'm still around:

> "The good news is it would appear very few people are inclined to carry out anonymous bombings, in spite of the ease with which it can be done."
https://www.nerdwallet.com/article/investing/the-average-401...

https://www.gao.gov/blog/growing-disparities-retirement-acco...

https://www.gao.gov/financial-security-older-americans

(401k plans were a way for capital to con Americans that ditching pensions was the way to go; pension contributions became shareholder profits, and most did not or could not contribute to 401ks in any meaningful fashion)
This is also a 2008 document, at a much younger Google.
Ops guy... These days cloudflare allows you to put comments directly into their service, but for a long time I would just export the zonefile and annotate that. There is a KB article somewhere in jira that will tell you what stuff is. I can also summon the ticket history to see what changes were made and why.
Ask HN: How to survive indefinite DDoS attack?
Say I have a website that is under DDOS attack. Assume it will be going on indefinitely. Assume my hosting provider has DDOS protection that will protect my servers but at the same time users will be unable to access the website.

How can I survive being targeted like this? Cycling IP addresses and updating DNS ad infinitum does not seem like viable solution... because in the end, it's the network attacks that get you, not the application level attacks.
It wasn't about "autism", but there was a study done a while ago, where it was the "cranky independent" people who intervened most. They might have been left-styled or right-styled; what they had in common was that they didn't go along with the crowd.
the point is the owners have a positive exit that they choose. And yes people are agents
The edge is far better service and less scammy practices (pushing unneeded treatments/medications etc..), at least from what I heard locally about Dutch vets.

Incidentally in Belgium they just passed a law requiring each veterinary practice be owned by a veterinarian. Life could be simple...
Taking the emotion out of the analysis, all i am hearing is that the PE uses more capital, but produces a cheaper, more efficient service.

If the original small business owner sold, the money they got paid isn't gone - they could've used it to start another small business (or fund one as a VC themselves). I don't see how PE is stifling anything, but to produce a more intensely competitive environment.
Or, Toys R Us.
I deleted so much stuff from my old PCs due to disk space constraints at the time, and I wish so badly I had just bought another disk. It would be so great to still have some of that stuff, of not purely for historical record. You don't know what you'll miss 10 years from now.
Ta-Nehisi Coates' "The Case for Reparations" was eye-opening on a topic I thought I was already well-informed on, and it barely scratched the surface. So much stuff boiled to the surface in the almost 10 years since.
> I think the better question is: which writers is Amazon killing by favoring popularity over discovery?

> And what do I mean by success? Unique and special and important creative people living a sufficiently middle-class lifestyle to continue providing us with their gift(s).

> Amazon's filter has created a world where that is nigh on impossible.

These paragraphs are what I was replying to. If you wanted to talk about Amazon's effects on consumer's ability to find things rather than its effects on authors' ability to make a living, don't bring up the latter.

You can't make claims about Amazon's effects on authors and then act like I'm going off topic when I call those claims out as problematic.
Thanks for this pile of links...

I don't believe what you're saying that 401k's are somehow not going to be enough to retire.

Unless you meant retire where housing prices are rising the fastest.
I was planning to get work done this morning...
This both ablates (Illich’s “fallen” status) and distorts (natural cosmos vs. natural world, the latter being “scientific” in exactly the way Illich ordinarily critiques) the original meaning of the sentence.

ChatGPT is a remarkable achievement in machine learning, but this demonstrates exactly why it can’t be used to accurately summarize complex ideas.
Vet is probably a very good example of economies of scale. I remember a vet in my town in Brazil complaining how hard it is if he get ill (or take vacations i presume), that he will lose his customers and how much he regretted not becoming a state employee.
> I can smell a classic car from several hundred meters away inside my car

It's worth noting that most classic cars are tuned running too rich fuel mixture - because they are driven so rarely, it's more important that the engine runs at all than that the engine is running efficiently.

Those cars smelled different - once the choke was off - wen they where new.
Did you know that most gender affirming surgeries for minors are breast enlargements and reductions for cis girls (born as a girl, not transitioning)?
You didn't read the links then. Median 401k balance is no more than $71k across all age cohorts. Assuming a 4% perpetual withdrawal rate (Trinity study), that is ~$2840/year in income.

Per the GAO:

> Even for those who do have access, traditional defined benefit pensions have become much less common as defined contribution plans, such as 401(k)s, have become the primary type of retirement plan. This shift has increased the risks and responsibilities for individuals in planning and managing their retirement. Yet research shows that many households are ill-equipped for this task and have little or no retirement savings. As of 2016, about half of households with a worker age 55 and older had no retirement savings, and 29% had no retirement savings or a defined benefit plan. Policymakers will need to consider how to best encourage expanded pension coverage, adequate and secure pension benefits, and more effective use of tax preferences to foster workers’ retirement security.

40% of Social Security recipients have no other income.

https://www.ssa.gov/news/press/factsheets/basicfact-alt.pdf

https://web.archive.org/web/20231028173718/https://www.nirso...
Show HN: Gobeats, a Google Drive command line music player
> Second, never ever ever use any cloud based back up unless you are just using it for a back up of your multiple hard drive backups.

Sorry, no, this is signing me up for too much work, never mind all my non-technical family members.

The whole point of cloud photo services is to eliminate the technical challenge of file management.
> Providing evidence to claims is now a higher standard? man you live in a wild world.

Yep, that's the world we live in. Politicians, corporations, journalists frequently don't. Even "scientists" from time to time fake data & results. Military at least have a valid reason for not publicizing intel, specially in times of war.
Sure, no one is blaming any individual business for selling. Nor would you blame any particular drop of water for flowing downhill. Still, too much water will make a dam burst and most of the water will flood the land; too much business owners realizing their retirement plan by selling out to PEs, and everyone suffers - including those retirees.
Again, it is efficient at what it does.
Care to elaborate on why you believe that?
i cannot answer objectively for obvious reasons. but i am very happy with Go back-end, Quasar front-end, JSON for message formatting and MariaDB for data storage. I have made couple of project in this manner, in addition to previous ones, so I am very happy with this setup and cannot really imagine trying anything else that would work better. Quasar can be also built into a mobile app which is another bonus.
They know how the program is intended to behave, what it's core functionality is. They have a model of how the software should work. A tool that allows them to encode that model into a policy is ideal.

The point is that they don't have to understand organizational policies, they just have to understand their program - does it use network, talk to the filesystem, etc.

If you want to enforce broader policies SELinux is not going anywhere.
AMD & Intel also pay $0 for licensing costs. For the phone markets & up through servers, licensing costs are a rounding error on what you pay. You're paying for the R&D of actually designing the chip itself, not the ISA, as well as for the actual manufacturing itself.
There are two sides to this issue.

On one hand, the InfoSec side where you want to hide info. On the other side, the service provider doing the validation WANTS to advertise their service on these DNS records so they are disincentivized to make the changes you’re suggesting.
Sarbanes-Oxley
https://www.investopedia.com/terms/s/sarbanesoxleyact.asp
Good point, I hadn't considered that.

I wonder what the defining moment of drone combat will be? The equivalent of the Battle of Agincourt where English longbows devastated the opposing French force.
> They just stop the onset of secondary sex characteristics until a more appropriate age.

At which point if they still did take puberty blockers at this more appropriate (critical?) age, wouldn't there be permanent effects?
Yeah avr-gcc is pretty thin and it would be nice if the memory mapped registers had clearer names. That being said, there's a balance between being close enough to the hardware to get predictable timings and the necessary flexibility and being abstract enough that the code is easy to understand by people without domain specific knowledge. You can get closer to the latter by providing increasingly thick layers of abstraction.

The problem is that making the abstractions perfect (and arduino's are not, probably for this reason) can take a LOT of code.

These Atmel chips are pretty tiny and memory constrained compared to what you might be used to. And that is not even to mention the performance overhead these abstractions can incur.

Sometimes you also run into fundamental impedance mismatch issues. Situations where you can't present a high level interface to something without having to make unacceptable compromises.

All in all, while arduino is convenient for a beginner to get started, the second the beginner starts to get serious about hardware development is the second the issues begin appearing.

You can get quite far with arduino but if you want to use a device like the ATTiny85 to its full potential, you're going to struggle.
A big enough gap that you'd pay hundreds of dollars to cross it?
As I said, it's not really about the leash -- nor the sign.

It's about people who deputise themselves in the service of these rules, and who imagine risk, and appoint themselves enforces of a social order of values that is insensitive to particulars.

There are many things I dislike, take littering. I would find it very obnoxious for a person to litter in a park, and to ignore the signs against it.

But I feel no compulsion to go discipline them, or involve myself in their disciplining, or deputise myself as a member of some social police force. Were they to be murdering someone, that would be different.

I am not a person who 'thinks of the children', quite the opposite. I think of a world designed for children, and would then go out of my way to destroy it.

I am unsympathetic with these 'daily oppressions' which constrain people's lived freedom, in the service of radical abstractions with marginal effects; the service of imagined dangers, and the like.

I would much prefer a society in which people occasionally littered to one in which no one dead out of fear of some reprisal.

The problem with "what's the harm" thinking is its aggregation. When you have disciplined people's daily lives to that degree where all these "what's the harm"-level rules are in operation -- then you're living in a nightmare.

It is for this reason I took against ever living in america. Where 'neighbourly policing' seems everywhere; and 'city bylaws' run amok
This article seems to be stretching really hard to find any way to connect private equity with "bad things".

I found the "private companies are kind of like public companies pre-1929-stock-market-crash" take to be particularly incoherent.

There might be a good steel-man argument for "privately owned companies are bad", but this article doesn't look like it.
The only thing you need to know to use pledge is what kernel features you access (file system, network, etc).
Best one so far:
"Tell windows ppl to just use WSL (see #2)"
Think of Comcast but for puppies' health
I have two shared albums on Google Photos. One is an archive that holds (essentially) every picture of our kids. The other is a curated album of pictures from the first. But I started these albums when our twins were born, and now we've got 3 kids, so there's... ~12,000 in the everything album and ~700 in the curated album. I try to get a couple of pictures in there every week or two, since we don't do social media but want to share pictures with family and friends.
> In fairness std::allocator has always been a wreck

std::allocator is just fine - it's no more and no less than a wrapper around malloc/free and that's what it really only needs to be. If you need a different allocation scheme that your workload is going to benefit from: (1) you first need to come up with it by finding out what scheme is going to benefit you, (2) you then implement it through a custom allocator.

> Most per-method allocations should be pointer bumped in an arena ... and the languages just don’t encourage it.

System malloc implementation will do that by themselves whenever they see fit. And this is not the programming language problem to begin with at all.
I accidentally saved my company half a million dollars
Some foods boost levels of an Ozempic-like hormone
How is this different than low-background steel? The 20th century left a mark.
There aren't technical barriers but two huge social barriers immediately come to mind:

- Timezone

- Culture

Working with people in vastly different timezones is difficult. Just ask anybody working with people from the the US East coast and West coast. That's only a 3 hour time difference and it gets difficult.

Culture is another barrier. One of the things that's been hard for US-based companies to learn with working with people from India is in their culture it's impolite to say "no." They use other signals to indicate no. Americans miss those cues. They don't hear what the think is pushback and so they proceed as though everything were fine. Americans also find it difficult to work with Germans as their bluntness is seen as being rude. This is just scratching the surface for the culture barriers that abound.

This is why I say remote work != offshoring. They're two completely different animals.
Who do you think the shareholders are? That's right, it includes 401(k) and retirement plan owners. It's a way to diversify your retirement beyond a single company. A pension plan in a company that can disappear and that can make investments on your behalf without any control is the big con.

The fact that people contribute less to their 401(k) means they care less about saving for retirement, not that the plans themselves are a con. I personally don't even have a 401(k) because I am self employed and there are other options.
That is a capture card and not an encoder card. It does not feature any accelerated encoding and relies on the host system to provide the video encoding, usually via a dedicated or integrated GPU.
For the record, I get that donate popup on Signal every couple weeks, and it's all the more annoying because I donated for several years until they recently removed SMS support.
https://en.wikipedia.org/wiki/Methods_of_computing_square_ro...

python implementation (for numbers >= 2)

def bakshali(S, iters=5, a=0, b=0):

x = S//2

print(f'inital approximation = {x}')

for n in range(iters):

a = (S - x**2) / (2*x)

b = x + a

print(f'{x}')

x = b - (a**2)/(2*b)

return x

Converges pretty fast!
I know for sure that in unoccupied territories Ukrainians do great job keeping their communications reliably working (to the point that there are plenty of software development businesses successfully doing their jobs despite of war) unless a rocket hits some piece of infrastructure nearby. Which sort of disproves your claim. Zero blackouts were caused by hacking, and multiple by explosions.
The actual problem is that the unmonetizable value gets tossed out by PE. E.g. customer service will take a massive dive because everyone working for the clinic or whatever else will be time-pressured out of good service.

Generally the problem with treating everything via pure financial models is that some things are valuable but hard to measure financially and those are inevitably destroyed by PE and other entropy-maximizers.
Break down your Terraform into Stacks
i have been using firefox+uBlock Origin and until last week i only had to log out, clear all app data from brwoser and as precaution flush ubo cache, once a day and that worked. but since couple of days ago i have not had to log out and it works just like always. either ubo got some new filter or youtube reverted some intrusive changes.

i have also installed freetube which works great except recommendations because you are not logged into youtube so it lacks history.
This is not snobbery, some subjects just have prerequisites.

You can't learn computer science without having a good sense of what an "algorithm" is, you have to know how to read and write and understand algorithms. Similarly you can't learn math without having a good sense of what a proof is, reading, writing and understanding proofs is the heart of what math is.

Even more strongly, trying to learn math without a solid understanding of how proofs work is something like studying English literature while refusing to learn how to read English.
Why would you bring that up in relation to " Richard Stallman #metoo cancellation attempt", unless you were trying to insinuate some sort of connection between his "obnoxious antisocial" tendencies and the sexual predator allegations (that is what is meant by "#metoo cancellation attempt")
I've fried a couple things over the years plugging in the wrong power supply (always during a move/reno when multiple things were being replugged) so the ability to have the device negotiate it's own voltage from a standard source that can be reused is a blessing. I still have a collection of random wall worts from the past just in case, but never seem to have the one I need when something dies.
Not sure what you are saying here. Which companies? Why?
When I moved and was looking for a new vet and dentist, I specifically asked each one about their ownership structure and didn't choose any that were owned by a PE firm.
https://www.cnbc.com/2021/10/18/the-wealthiest-10percent-of-... ("The wealthiest 10% of Americans own a record 89% of all U.S. stocks")

https://www.usnews.com/news/national-news/articles/2021-03-1... ("Median household owns $15k in equities")

(unless you're wealthy, you are a token participant in the capital markets)
research output from china is already outpacing the us...

and their point is that the open source movement is not driven by capital / neoliberal economics
They sell the HP prime, which is in many ways an evolution the the 48GX, and for some markets, they still sell the 50G, which is even closer to the 48.

All of them are fantastic. And once on RPN, it's hard to go back.
System level security seems to be the real solution to memory safety. Declaring invariants for an entire program gives you much more peace of mind than hoping there are no bugs in JVM.

Process separation is already a success story that eliminates who classes of exploits.