skysight-inc/HackerNews huggingface dataset:
Latch Registry: An Integrated Database for Multi-Omics
Throughout the entire R&D life cycle, scientists must track samples and project metadata across Excel spreadsheets and internal LIMs, while computational teams must link raw data and reports to those samples.

With no database linking wet lab <> dry lab, current solutions are siloed between AWS, Excel, ELNs, and Powerpoint, leading to a lack of traceability, lower visibility and slower decision making in R&D.

This is why our team built Latch Registry: An integrated database for multi-omics.

Registry allows you to track everything, linking data from your patients → tissues → samples → specimens → slides → assays → raw data objects → analysis objects in a single place. This makes it easy to access, explore, and query data for insight.

Registry is integrated with the rest of the Latch ecosystem.

1/ Latch Data: An intuitive biological file system for flexible data organization on AWS S3.

Easily link data objects to extensive metadata stored within the Registry.

2/ Latch Workflows: Import samples from your Registry to bioinformatics workflows for processing those samples. A workflow can also write back to the Registry tables using Python APIs.

3/ Pods: Latch Pods are scalable and flexible compute environments with RStudio & Jupyter Labs pre-installed. This enables collaborative, scalable downstream analysis of results.

Spin up a Pod and use the Registry API to retrieve a panda dataframe of any Registry table.

Read more here: https://blog.latch.bio/p/latch-registry-an-integrated-databa...
It certainly won't be if we don't build the infrastructure to send (temporarily, at least) people to Mars.

Can we bootstrap up an energy economy there? Dunno, that's the first step. With a large enough energy budget, food's doable. Water is likely in situ.

> It seems like surviving the loss of Earth is a long way off regardless.

Even longer if you wait to try.
Same here (Millenial), the scenes are usually just dishonest and uncomfortable padding of runtime, adding nothing to the plot or the vibe. There must be some market research that prompts its inclusion, I can't understand why they do it.
TIL that Chile, Bolivia, Argentina, and Australia are all part of 'China'
>When there's media with too much sex, me and my friends often feel uncomfortable

Exactly. It is disgusting.
Tell that to Apple, Google doesn't have the power to give you that.

Edit: Also Google would love a law enforcing that, since now they don't have to pay all of these billions of dollars and most people would pick Google in that choice anyway. The main players that doesn't want that are Apple and the others that auctions out default search.

So Google convincing the judges to stop Apple from auctioning out default search would be a Google win.
Not only that, but enjoyable for all ages. They pay extra attention to details, and think about the experience from different age groups. For example on Super Mario Bros on Switch, when playing multiplayer you can tap both L+R to put your character in a safe bubble that floats and follows the rest of the players. This allows younger players to flee to safety in really difficult parts of levels, while older players can help them navigate to the next area before popping their bubble and bringing them back into the game. Such a small detail, but makes a massive difference when you're playing with the game with younger kids.
This feels like a needlessly hostile take. As someone who uses C++ daily, I am glad Bjarne is still around and contributing to the language.
Thanks, are the specific details standardized and available in writing? Or is it more tailored to each customer?
Japanese society is collectivism, not socialism. They have a long history and many traditions around keeping social harmony. This is has both good and bad effects.

This gets confused for socialism because when action happens, everyone is on the same page and working to support the action. Before that point, there are lots of meeting and discussions to create harmony and make sure that everyone agrees with the action. Sometimes this is lead bottom up, workers will get an idea and circulate it to get everyone's buy in but without the upper management's approval, no one will try an idea for fear of causing offense. Which leads me in to how they are very authoritarianism, if the boss tells you a poster is blue not green, everyone will agree that it is blue. Only after the boss is gone will people stand around and question the edict.

If you look at how Toyota reacted to electric vehicles, someone did not like the idea or their pet project was fuel cells and that is the direction they took for a long time, rather than hedge their bets and split focus that is what they were committed to and now they are late to the EV party where they had a large head start with the Prius.
CLIP is a such a nice paradigm shift. Historically, CV things were quite limited:

- You could predict a class (from a static list such as [dog,cat, ...]) or ...

- You could use image embeddings disconnected from text (you could tell image look-alikes but not what they actually represent). By "embedding" text and images in the same latent space, you can now query your images with text query (such a "a large dog") and find the relevant photos. CLIP understands semantics but also is not limited to a set list of classes (thanks to the ability to use of web data in training).

This is a list compiled by OpenCLIP of high performance models (some better than MetaCLIP) for those interested in using CLIP:
https://github.com/mlfoundations/open_clip/blob/main/docs/op...
> Google quietly planned to put a lid on Apple’s search ambitions. The company looked for ways to undercut Spotlight by producing its own version for iPhones and to persuade more iPhone users to use Google’s Chrome web browser instead of Apple’s Safari browser, according to internal Google documents reviewed by The New York Times.

So their top secret plan is to.. make a competing product? AKA what all companies always do with their competition?
> From testbench to fitting 10k screens across 700 stores, without intermediate testrun in a few stores?!?

People often forget that when "moving fast and breaking things", some parts are more frangible than others.
Ah yes, clustering is indeed something that would benefit from large context, I agree.

However even so I would think about the documents themselves and figure out if it is even needed. Lets say we are talking about clustering court proceedings. I'd rather extract the abstract from these document, embed and cluster those instead of the whole text.
It's a real shame that drugs like cialis / tadalafil have negative social/cultural stereotype due to the meaning we attach to unaided sexual prowess and shame to sexual difficulties, as it really does feel like a drug that just makes sex better for people with sexual difficulties but also make sex amazing for people with normal sexual function. And likely has other unknown long-term benefits as well.
It's also an unfinished language. I agree Zig is promising, but it's not confidence inspiring when the creator is still making videos debugging the compiler.
Then you should build that space company. Show us how it's done.
They are not complying. They never came any close to complying. If they started complying all the discussion here would be of confused people trying to make sense of something they never thought Apple could ever do.

All they did is some PR pretending to support a law they will clearly refuse to obey. There is no explanation for this except that it's a Machiavellian act.
By oven do you mean the one in my kitchen?

It gets up to 500F but a good pizza oven goes hotter. For a wok the stove top is gas but the answer is no. It won't get the sear I want.

To overcome this, I have a cuisanart pellet smoker and a big green egg. Those can get me into the 600F range that gets me the pizza cooking temps I want.

For the sear, I just cook on my griddle since the whole surface goes up to 600-700F with that new regulator.

Honestly if I had pro grade appliances, I'd need a massive vent hood and some sort of advanced fire suppression because ho le fook do those grills get hot.
Interview with Shane Legg (Chief AGI Scientist, DeepMind) [video]
Ummm yes? The overwhelming majority of articles on this site are addressing 1st world problems. Are you posting this from your MSF rotation in Gaza?
Top Gun is the emblematic dumb romance subplot. I feel like mostly everyone who watches this movie today for the first time feels similarly negative about it.

But I also know a bunch of older folks who are insistent that it was an amazing romance. I’m not clear when and how this perspective changed.

I can’t think of a single cinematic romance that I really cared about (although I’m sure there are a few examples?). But I also hate the annoying hypervirgins you get in stuff like anime where it’s just kind of annoying that characters can’t just release their palpable and constant sexual tension and start acting like someone who is normal and confident.

At the end of the, I feel like anyone in film whose whole character thing is trying to figure out love ends up being a really annoying and unrealistic character.
Figma has responsive design and reflow tools built in these days.
As with the comment above yours, it just rarely adds anything. And by erotic standards most of it is shit in that department. I love and enjoy adult entertainment and if I want to be titillated, I'll go watch some of that. A few minutes of the softest softcore imaginable is basically just filler.

I don't hate it, and when it's part of a plot of course it makes sense, but a number of the ones in Game of Thrones I recall were just pointlessly long, sometimes disturbing excuses to get the pearl clutchers riled up and get hate shares on social media. It's tiresome. If your art can't stand on it's own don't make it.
Openbenchmarking.org – Cross-Platform, Open-Source Benchmarking Platform
He’s conflating all of the resources spent with the outcomes involved. Need to see the graph?

https://en.m.wikipedia.org/wiki/File:NASA-Budget-Federal.svg

Now imagine if those same resources were spent on fusion propulsion…
> only the device owner can see where a device is

Apple itself can also see where it is. This automatically means the NSA can also see where it is.
GCP is a gigantic organization and I was a cog in a machine.

I was aware that people criticized GCP for various reasons, but there wasn’t much I could do beyond my team/product area.
Personally my feelings on this lately have been 'shit or get off the pot'.

You can put romance, drama, and even sex in your TV show but please just get somewhere with it. If I start getting CW flash/arrow vibes I am turning it off. I can just read abandoned web serials for that if it's what I want.
I agree with your points, just trying to build on that.

If Edge had some feature that is impossible to miss (I guess like Chrome integration with google stuff), then people would feel more compelled to use it?

Apart from that, if it is only a marketing issue, they should start by doing better marketing, perhaps.
Here’s a single $680MM observatory that looks pretty pissed and is struggling to figure out how they’ll deal with it. Granted probably won’t drive the value to zero, but it probably will devalue the project quite substantially, from my read.

https://www.lsst.org/content/lsst-statement-regarding-increa...

And I’m not arguing for stopping further spacecraft either.

“Hey they don’t even legally need to mitigate their externalities!” is usually a good sign of “things that need regulation.”
> nihilistic

I don't really see this though replace nihilistic with narcissistic and you may be on to something. It's not a belief in nothing, it's a belief in "I."

We are losing the ability to disagree and still keep it civil for one because of identities being so tied to the -ism of the day and no one accepting that they may be wrong about something every once in a while.

The same drive to be independent and "self-made" is becoming a weakness. It's going to an extreme where every man is an island.
You have obviously never watched the "Porky's" genre 80s movies.

https://www.imdb.com/title/tt0084522/
I recently implemented some code to: Sign into an account using username/password/MFA, authenticate with an API using OAuth to get a SAML assertion, authenticate with another API using the SAML assertion to get a token, then sign into an API using the token...

Why do we do this to ourselves?
They affect health by creating enormous numbers of new fields for research and medicine, which after patent expiry is generified and manufactured cheaply for eternity.
Are these cases all implicit flow, except the Grammarly case where a bug/misconfiguration made it accept the implicit flow param anyway?
The place had Wi-Fi, but the phone was just enough apart from the router to not reach it. The calls were WhatsApp Calls because we knew there was no cell service to make a standard call (don't know if the phone has VoLTE).
I'll save you the wait. Rossmann will never voice full-throated support, no matter what Apple does.

Not only because his clout now heavily depends on dissent but also because his individual needs go far beyond that of the average repair shop, much less the average consumer.

There is no world in which Apple can meet those needs short of him getting direct access to all internal classified documentation and the assembly line to pick and grab any piece and part he might desire.
Yeah, I just skimmed through the reference docs for Hubris and was very impressed with what I saw. No "rocket science", just (apparently) solid technical decisions that are extremely well justified and documented.

https://oxidecomputer.github.io/hubris/reference/
So one thing I was thinking about is that maybe this reflects a change in how movies are watched and who they are watching them with.

A sex scene may be a welcome addition if you are watching it with a date or partner, and less welcome if you watch it yourself or with family.
As a millennial, I can agree with them on this. The second Matrix movie would've been as good if not better than the first, if it weren't for the weird Zion sex scene between Neo & Trinity.

Those type of scenes don't further the plot, but rather push out the engagement of the film from a viewers perspective.
Earthquake in Mexico City Reveals 500-Year-Old Aztec Snakehead
This seems like a manufactured moral panic. I don't think we're entering a new age of prudery. Even if the survey is reflective of a broader change, taste in media ebbs and flows.

I highly recommend listening to You Must Remember This, Karina Longworth's movie history podcast. Specifically, the most recent two seasons have been about sex in movies in the 80s and 90s. She does a lot to ground changes in depictions of sex in movies in their political and cultural moment. The episodes vary in quality, but the best have been enlightening. I think she's sympathetic to the narrative that "Gen Z is prude" because she's a big fan of nuanced depictions of sex in movies, and sees a decline. And yet, listening to the podcast you can't help but see these trends as somewhat cyclical, which is why I'm not worried.
Also, BSD is dying.
Musk is in the driver's seat at Twitter. At SpaceX he's a frontman, carefully managed by people who know both him and rocket science.
whether or not the astronaut is willing to take the risk, kidney stones can be so painful that someone suffering from them could potentially jeopardize the mission from incapacity or increased risk of making a mistake. Even if the astronaut were personally signed up for a suicide mission, there's a lot of incredibly expensive and difficult science and exploration to be done.
https://en.wikipedia.org/wiki/Rai_stones

In Micronesia there was a practice of carving massive "coins" out of stone. These "Rai stones" were often too large to move. Yet individuals could "own" them and they were traded often for things of great value. I believe I even read an account of one that had sunk in a shipwreck, but the owners went on to trade it even though it was at the bottom of the sea.

Just cause a physical item cannot be possessed physically doesn't mean it is valueless.

However, for gold specifically, part of what makes it valuable is that it has some manufacturing uses and people like making jewelry out of it. There is no doubt a much larger supply of gold throughout the universe than on earth and it has no effect on the price here.

So I think while you can buy and sell gold on another planet (provided people can widely agree on it's transfer of ownership), that would be a completely separate market from the terrestrial gold market.
> completely unsupported

That equation changes with the entire software stack being open-source
> how should we think about it?

I am not in sales and so I hesitate to speak on it in case I am incorrect, but the way that I personally think about it is that it is true that it is not an inexpensive product: there's a LOT of computer here. But the goal is to be competitively priced.
It’s going to get even easier once container queries are widely deployed (if they’re not already).

We’ll be able to design components to scale to their parent instead of screen size, making them much more generic.
Sounds like a nightmare when trying to copy-paste text ?
So we risk a human dying 40 days from help and severely overcomplicate the mission just for the public to not care even a tenth as much as they did during the apollo era. I wish we had a space program that didn’t rely so much on sacrificial heroics and building of a public myth.
Not sure that's the case. I think this is more a Gen Z thing. Most millennials I know think Gen Z is "not great" in their conservative outlook. (Don't even get me started on Gen Z fashion.)

Hipsters were despised back in my day, even by hipsters themselves, but in the end I think we all had a lot more fun than Gen Z today. I wouldn't change any of it.
Feelings of the public matter when groceries start costing double, or triple in some cases. What once filled my entire fridge now gets me one shelf. Rich propagandists don't feel this. Everybody in my life that I talk to however, do.
Of course they were being hyperbolic with the use of the word "billions". The point still stands though. The vast majority of people using Google's services do know about adtech surveillance, and just don't care.
Costco almost isn't a fair way to compare prices because they have intentionally been losing margin and raising prices as slowly as possible to retain customers.
Like Gen Z doesn't want to police the hell out of everything too. I think culture has just shifted.
> A human being landing on Mars would probably be the single most watched event in human history.

I'm actually skeptical about that. It certainly would be the "single most watched event in human history" among geeks interested in space, and probably among geeks in general and nationalists of the country that did the landing, but I suspect it's a biased projection to extend that attitude to all of humanity. Objectively, it's likely that stuff like the opening days of some war or the 9/11 attacks would be more watched than a Mars landing.

Apropos: Gil Scott-Heron - Whitey On the Moon (Official Audio): https://www.youtube.com/watch?v=goh2x_G0ct4
With no buried fiber to feed on, the backhoes will starve.
I feel the same way, and I'm in my mid-40's. I always end up wondering why am I watching this stylized sexual encounter (which doesn't match almost anyone's experience almost any time) and often with people I don't really want to watch it with (teenage and adult children). If some light foreplay shows something about the characters, that's fine, or if something actually happened during the act that was important, that's also fine, but otherwise it's just gratuitous and annoying.

If I want to watch porn, I'll watch porn, I'm sure as hell not going to opt for some scene in a regular movie. Then again, maybe it's for people that refuse to watch porn for one reason or another and this is as close as they get?
The problem with a UCLA-sponsored survey of teens is always going to be response bias.

For example:

>Very few adolescents prefer aspirational content. The majority favor original content over IP-based content. Also, the majority prefer binge releases over weekly releases.

A quick search of the top Youtubers shows that Gen Z in fact loves aspirational content, they just don't like the image that comes into their head when they hear the term.

A quick scan of the box office shows that they also love IP-based content, unless all the viewers of Spiderman, Barbie, Mario, Guardians of the Galaxy, Fast X, and The Little Mermaid were over 25 (Hell, even Oppenheimer was technically IP-based).

I believe the binge watching thing though.
You missed the Cowboy Neal option
Coupling vs Decoupling is not some one-sided thing. It's a major trade-off.

One of the most obvious examples of the problem with this approach is that they're shipping previous generation servers on Day 1. One can easily buy current generation AMD servers from a number of vendors.

They will also likely charge a significant premium over decoupled vendors that are forced to compete head-to-head for a specific role (server vendor, switch vendor, etc).

Their coupling approach will most likely leave them perpetually behind and more expensive.

But there are advantages too. Their stuff should be simpler to use and require less in-house expertise to operate well.

This is probably a reasonable trade-off for government agencies and the like, but will probably never be ideal for more savvy customers.

And I don't know how truly open source their work is but if it's truly open source, they'll most likely find themselves turned into a software company with an open core model. Other vendors that are already at scale can almost certainly assemble hardware better than they can.
You and I live in completely different worlds. I will absolutely not complete a purchase if your website is unusable.

In fact, this happened last week--I was trying to purchase a plane ticket and the animations were so excessive and poorly done that it obscurbed a form field that made it impossible to book the ticket. I bounced and booked a ticket from a competing airline.
I remember reading an article on how movies and TV today are not quite able to make meaningful and interesting sex scenes that are actually well made and add to the story. I think this was specifically for western movies. But I can't find it now.
A large proportion of the people I know who fulminate about "illegal immigration" had relatives who came here under at best cattle-call circumstances, if not outright "illegal" ones themselves. A nontrivial portion of my generation's Boston Irish grandmothers, great-grandmothers, and great-great-grandmothers did not necessarily have all their papers in order; it's just far enough back to somehow legitimate it.

Also, they're white, and that plays a role--even today there's a surprising number of undocumented Irish immigrants to the United States but nobody's out there asking for reactionary measures to that.

It's not always racism...but it is mostly ladder-pulling, and economically unrealistic ladder-pulling at that. (Ask a farmer.)
> Well, Edge has objectively been better than Chrome on Windows (faster, less memory usage, longer battery life) for years now, but almost nobody knows this as people still default to installing Chrome out of 10+ years of habit.

Or maybe it's not habit because Edge is objectively tied for worst browser on Windows on privacy:
https://apple.slashdot.org/story/20/03/07/0054219/edge-br
owser-scores-worst-in-test-of-telemetry-privacy
Eh, there's room for 'Cadillac Man' in there too, throw in 'Lawnmower Man' and you've got the whole gen-X Man trilogy.

Not Encino Man though, that film never existed.