skysight-inc/HackerNews huggingface dataset:
Not exactly a programmer, but a professor of computer science.
He was the mayor of the city where I lived

https://en.wikipedia.org/wiki/Furio_Honsell
We are talking about incurable (refractory) cancer cases in which, after treatment, 95% saw either stabilisation or regression of the disease, and 59% showed significant regression or reduction. This is absolutely awesome news.
This is my experience, too. Bupropion (Wellbutrin) seems to dampen the spike of cortisol or adrenaline or something that I can get when something really irritates me. As a single father of two middle school age boys, it has helped a lot.

Btw, have you noticed exposure to sunlight to make you even more laid back? I've recently been casually tracking a correlation in that for myself.
New Vegas was good though. And Fallout4 was lazy writing, but good ideas overall. And the best Bethseda DLC ever was Far Harbor, it isn't even close. To me it's the best DLC, or at least the content DLC that added the most interesting story to any game.
Lawrence Lessig on why AI and social media are causing a free speech crisis
Study: To Excel at engineering design, generative AI must learn to innovate
Looks like it requires good hardware to run this? My GPU is too old for this.
Despite the downvotes, I believe this is true: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC164356/
I remember that article from the NY Times Magazine, it was from 2008. Here's a link for anyone that's interested: https://nyti.ms/3ScsVm5

It's long but a good read, particularly if you've got daughters in sports.
Rest assured that workers bees do shit upon your crops.
I've always disliked the RISC-V instruction encoding. The C extension was an after thought and IMHO could have been done better if it were designed in from the start. I'm also a fan of immediate data (after the opcode), which for RISC-V I would have made come in 16,32,64 bit sizes. The encoding of constants into the 32-bit instruction word is really ugly and also wastes opcode space.

After all the Vector, AI, and graphics stuff is hashed out I'd like to see a RISC-VI with all the same specs but totally redone instruction encoding. But maybe that's just me.
Awww. Aren't you delusionally pathetic. I said you were trying to suppress dissent about your dear leader with your pathetic propaganda tactics. I didn't say you were successful. Your dear leader is a tool and you're a fool for parroting his propaganda. Run along now.
Falling behind: postdocs in their thirties tire of putting life on hold
Thomas Massie would be the example that comes to mind.
Resistance training is known to build bone density too.

Our bodies weren't "made to" run on concrete. Our (male) ancestors hunted by chasing animals on soft ground for a long time, sure. That's a lot lower impact than a lot of sports that injure people.
I say blame them both. TSA servants are more than complicit in the abuse of rights.
I found this easier to just explain as a factor instead of speaking of percentages. If you win, your money gets bigger by a factor of 1.8. If you lose, your money gets smaller by a factor of 2 or multiplied by a factor of 1/2. So you find your end value by just multiplying all these factors up.

Obviously if the number of winnings and losings is the same, you’ll be multiplying by 1.8 as often as dividing by 2, so on average your money will get smaller by like 0.9 each round. Not counter-intuitive if you think in terms of factors.
Paging/On Call, SIRT/Incident Management, Postmortem Analysis, SLOs, DFIR, Uptime Monitoring... Costs add up quickly. Isn't it about time we look towards open-source to streamline and reduce these costs? Thoughts?
> Like what if a print head could hide in a frame. Move up/down and across whole printing, and if it weren't on some sort of reusable surface, like a dry erase board.

You know, that almost sounds like eInk ;)
> Here's hoping more accurate dosing will be a side effect of this. Going by rough weight of a plant that includes a lot of water always seemed kind of sketchy to me.

> I've heard of tinctures made by dissolving them in alcohol, but I don't think even those are measured objectively. No idea what sort of titration/measurement you'd do to determine the mg amount of psilocybin, or if that's even well documented.

You could create a tincture and test it. And like the other person who replied said, the doses will be consistent.

Personally I took magic mushrooms once. I've always been an anxious person. For at least 2 or 3 months after. My anxiety was gone like never before, I was not scared of anything or talking to anyone. I was the most free I ever was. Ive been wanting to take another dose soon, I think I should... 1g.

I make full spectrum CBD oil for myself and family. It has a very real effect too. Much more powerful than most CBD products you can purchase, because it will contain more than pure CBD. Its the same process as a tincture with a few steps after. I turn 4 ounces (112g) into 60ml. ~300+ mg/g, take 0.05-0.1g. I think the benefits should be experienced without expectations, because they can vary. Helps with stress, anxiety, blood pressure, inflammation and some pain, arthritis, and others. There are some other compounds in this plant that can help with other things. CBG/A CBN, CBDA. A tiny bit of THC, which is naturally found in tiny amounts in most CBD containing plants, increases the effects of the others greatly. Too much THC alone has a negative impact if you continue long term use, at least on me. These compounds effect the endocannabinoid system, but have some off target activity which is why a variety of similar compounds can have a lot of different effects. Those other compounds can help with different issues-digestion, sleep. Keeping a decent amount of CBD/G(A) (by not cooking/heating it) is important too.

I am a very scientific person, and I understand some people are weary of this type of medicine. But what is your alternative? Eat the pills by big pharma filled with lies to sell drugs and make money? Take an SSRI so you can kill your sex drive and feel like a zombie? Maybe that won't happen to you, and I understand that they help some or many people. But if you understood the potential negative effects, and that some of them can be permanent, would you still be okay with starting it yourself? Perhaps something that has grown in nature with us can be beneficial, we came from the same planet, we evolved together. We consider other plants and vegetables from this earth to be healthy for us, why? Coffee, tea, in moderation, are good for you too. Tea is more than just caffeine.
Then you had a great starting point. Replacing a gas heater with a heat pump at sub 1000 euro annual heating costs will not pay back fast, for example.
This is how a Gallery Plus pixel works:

https://www.eink.com/upload/2023_03_20/3_20230320084544bgu5x...
> Nevertheless, noyb will give companies a one-month grace period to comply with EU laws before filing the formal complaint.

They sent draft complaints to the companies. Not sure how many they sent to authorities. But nevertheless it may have had an effect.
It's good to see that people care about native JS standards. I'm a bit concerned how Bun seems to be adding their own proprietary APIs to their JS runtime, and can't help feeling that it could be intentional vendor lock-in. Since they are venture backed I'm sure they want some ROI from the project eventually and if they start charging money it will be harder to switch away due to the proprietary APIs without refactoring your project.
office 365?
That's whataboutism; although it's true that there are no "good" sides in this conflict, the issue here is that supporting Israel is fine, but supporting Hamas is not because they have been declared a terrorist organization.

Nobody's going to get in trouble for opposing the conflict, or pointing out civilian casualties, displacement, war crimes, etc. But you WILL get on a List if you support Hamas in any way shape or form. Pick your battles, know the risk. Yeah it's not fair, just or morally correct, but this is the reality of things.
I find buffer useful for its conversion functions to/from different encodings, e.g., `Buffer.from(data, 'hex')` or `Buffer.toString('base64')`. Is there a good way to do this with `Uint8Array`?
>Interestingly enough it seems that there are more and more UX designers than ever yet the UX of so many applications keeps getting worse.

Lets say you have a population of 1,000 people and 1 doctor.

Then lets say you increase the amount of doctors to 3, but by that time your population is 5,000. Yea, you have more doctors than ever, but you also have more problems than ever. And we also see in the medical community more people want more treatment for more things. More staff, less time.

It is really easy as the end user to say "Oh, I could have made this much more simple for my workflow". But that's the thing, it's your workflow, you have no idea if that's the average users workflow. You have no idea if the 3% of the customers that pay by far the most money have a different workflow.

Complexity typically increases and keeps increasing till market saturation occurs. It's very unlikely we're anywhere close in software saturation (hell this could involve near complete replacement of people in most jobs). Competition means even if you want a simple app, another 'simple' app but with more features is apt to out compete you.
Well, seeing that a modern Apple monitor has the guts of an iPhone 11 and runs a version of iOS…
Yodobashi link in HN!? Anyway, here's Sharp product page found by model number EP-C251: https://smj.jp.sharp/bs/eposter/lineup/epc251.html
So if (when?) YouTube adds an "approve" button your platform will be destroyed?
You mean that Germany that shits in nuclear left and right, trying to block it from EU green agenda and then threatening it's neighbours when they wanted to went nuclear?
I think the exciting part is this:

“BNT211 continues to show encouraging antitumor activity in patients with CLDN6-positive relapsed or refractory advanced solid tumors” <- interesting because they finally demo some effect in solid tumors in humans

“Follow-up of efficacy data at 1x108 CAR-T cells with or without CARVac shows an overall response rate (“ORR”) of 59% and a disease control rate (“DCR”) of 95%, with the CARVac cohort demonstrating a prolonged persistence of CAR-T cells” <- interesting because those are high response rate. Let’s hope it lasts and they can increase those rates but as a patient, you would take this.
I've been trying to go 100% crypto since 2012. Been putting pretty much every penny I can into it since then. Of course Theres been ups and downs.

One time I got hacked by downloading a RAT off a torrent for a virtual machine and lost 10,000 ETH, now worth like $20,000,000.00 so that was annoying.

Then of course just the price swings, I'm down nearly $2million since the high point, so is that "lost"?

Never was stupid enough to buy an NFT, even though I TRIED to convince myself. That was just such a stupid time to be in crypto and I'm glad those people lost all that money. Morons.

Now I'm 100% XMR and BCH, they are the ONLY cruptoCURRENCIES that work and are needed, literally everything else in the space is a scam to take your money.
In this case, it's probably not that bad as with actual VLIW: if you see that e.g. your second 16-bit instruction has to be a NOP, you just use a single 32-bit instruction instead; similarly for 32- and 64-bit mixes.
Or distracting drivers. Who cares if people die and their lives get ruined if we get a few more $$ per day
Growth has slowed over the last year. I am experimenting with a second product idea to see if there's potential there while the industry recovers.
> Someone other than you has to read it once in a while; every 3-12 months most likely.

Not here. I assume that as long as your consumption figures aren't wildly implausible, they just leave you alone. You can voluntarily upload a picture of your meter while submitting the reading, but I've never bothered and they've never requested it.

Probably there are random spot checks, but personally I've never been subjected to one of those. They might also catch you when the meter finally gets replaced at some point, but power meters seem to be relatively long-lived, so they probably won't rely on that alone.
Best 401(k) Provider
Would anyone care to offer opinions as to the best 401(k) provider for smaller technology startups? We are considering Fidelity, CUNA, and Schwab and leaning Fidelity due to the lower cost and good reputation. But I don't know if their cookie-cutter plan (no profit sharing, no after-tax contributions) is likely to feel restrictive soon. The other plans seem to cost more and be more customizable.
I run a rather large API program for an Residential IoT manufacturer.

We have multiple systems, some with a public API some not.

The biggest problem is simply support. We'd LOVE to have more public ability to interact but I simply can't support every independent developer out there.

Also, people agree to a legal terms of service to get access BUT don't always follow it (e.g., data storage agreements, use case agreements, etc).

Coming at it from Mazda's POV, it could be that but it also could very well be the monetization aspect.
BTW: If you want to connect, there's a professional society for the discipline: Society for Technical Communication (STC).

https://www.stc.org

They have local chapters in many geographies. Their annual conference is usually well attended and covers topics related to technical writing from Help Authoring to Content Strategy to Content Marketing to Agile.
That sounds exactly like e-paper devices that already exist. Something like a Kindle Scribe.
1. Suited for very small implementations (~$0.10 uCs, tiny FPGA softcores etc). But scales easily to high-performance cpus.

2. Clean slate design, applying latest insights concerning cpu design, virtualization & so on.

3. More a community effort & perhaps more open than other ISAs.

OpenSPARC is (unlike early Sparc cpus) targeted at high-performance server / supercomputer chips.

Similar for OpenPOWER which is mostly an IBM affair. And opened only around the time RISC-V came out.

From what I've read (no personal experience), OpenRISC wasn't that well-designed or lacks RISC-Vs modularity.

So a combination of license, community, ISA design & timing of its introduction.
Especially if you're "politically active" in whatever form that may take.

And don't travel to Europe, the US or Israel if you've openly supported a terrorist organization.
It's definitely dependent on COL in area where you choose to retire, and what your expected spending is in retirement. Whether you decide to have children also has a pretty big impact. DINKs with a relatively modest income can still FIRE with substantial nest-eggs if their saving % is aggressive.

There's also been a cultural shift around FIRE in the last 10 or so years. The original mindset was focused on pretty extreme thriftiness and a general DIY approach to lowering annual expenses to maximize saving rate. Nowadays, the focus is much more on getting the biggest number possible, and maintaining a fairly affluent and luxurious (by early FIRE standards) lifestyle into retirement. To some extent that shift was fed by the money-printer near zero bound interest rate boom years of '08 to '19, so it will be interesting to see whether it maintains that trajectory.
>Cut the infinite exponential growth bullshit

This a byproduct of a much larger issue that affects all faculties, not just the tech sector. This won't change unless we as a nation choose a different economic model.
Can someone more knowledgeable on the subject please clarify if this proposed therapy requires personalization for each patient or if it can be (eventually) mass produced? Thanks!
I don't understand the headline.
> Either you make changes like what Qualcomm suggest here or you aren't competitive.

What's the evidence that the existing RISC-V approach is not competitive, and thus that Qualcomm's changes are necessary?
But what makes this unique versus the hundreds of other early studies that show "encouraging results"? The technique of CAR-T isn't exactly groundbreaking any more with 3 products already on the market. And the ORR of 59% is kinda of in line with current CAR-Ts.

I'm going to ESMO and this would be interesting but certainly not the highlight of the data releases.

Don't get me wrong, this may turn out to be very exciting, but it's very early data, and similar to other development programs has a 90% chance of failing.
It’s interesting to HN because BioNTech uses techniques to update a running (biological) system with analogues of patch files, temporarily lived cellular rootkits, etc.
I’m under the impression that most of these companies started to become heavily overpriced during the COVID-19 period.
I found that dosage of Sertraline made a notable difference for me. Too high a dose would get me in a hypomanic state. That may be where you were at when feeling superhuman. But mania can't last forever and is inevitably followed by a low.

Stopping cold turkey was bad news for me, too. I got the "zaps" any time I turned my head. So, I decided to taper down, which worked fine.
I am not quite convinced about companies making high-performance RISC-V design. Fastest SiFive cores are at best comparable with mid-performance cores from ARM (or E-cores from Apple). With SiFive likely stopping development of these cores altogether the only high-performance RISC-V design I am aware of is the upcoming Ascalon from Tenstorrent. Which (at least on paper) looks to be comparable to Apple's A12. Not quite cutting edge performance, at any rate.

Qualcomm's proposal to add complex addressing modes to RISC-V is a design that has been tested by time and is known to work. Apple (and now ARM, with X4) are using this ISA design to deliver enthusiast-level performance in a thermal envelope of a compact handheld device. It is not at all obvious to me that RISC-V, which requires the CPU to perform additional work to bundle operations for efficient execution, is capable of the same feat.
It's cheap labor for employers and bad news for German employees who felt the jobs weren't paid enough. The employees who wouldn't work for a "hungerlohn" are forced now as the emplyeers have absolutely no incentive to lower their profit margins, with all the Syrian refugees willing to work for less. I'm sure they're grateful and that they're doing better than in US occupied Syria (Isn't it great how much media coverage the Syrian invasion and civil displacement got?), but it's still an exploitative profit oriented system that's taking advantage of peoples situation.

Edit: Knowing HN, I'll be the one called racist as opposed to the comment right next to me that's saying terrible things about Muslims.
You could, but they can then choose to detain you further, do a full court case, and if they uncover evidence (or evidence that you did not, in fact, forget), you're screwed anyway.
Now you're maintaining an ever-changing external list for which there's no official API.
Heh, yeah, that is true

https://ibb.co/1m0bLWC

More cherrypicking and messing with styles is getting closer, but nothing like Dall-E's first try I'm sure.
It's about managing liability at that point, it's not a technical concern but a legal/regulatory one. If you have a contract with Okta and they screw it up, you have better legal recourse than just firing the guy internally. Security isn't exclusively a technical concern.
I'm using Dall-e 3 through ChatGPT but it seems to limit the amount of images I can generate per half hour. I haven't figured out the actual limit but sometimes I go to generate an image and it just says "You've reached your image generation cap please wait _n_ minutes before trying again"

Are you getting around that somehow? Even if it'll let me generate 36 images per half hour (which seems like it's probably lower than that) I can only generate 6k in 2 weeks prompting 24/7. I'm not scrutinizing your numbers I'm more hoping I'm missing some way to not have to be capped. I already pay for GPT+
I think that few people make a real concerted effort to rehab like you did. Thanks for the inspiration. Will look into it.
I wish it would adjust to the height of my terminal and do it all in one go instead of jumping down line breaks.
Buffer's `slice` is nice to have in many cases though. The pool makes it generally faster. And `allocUnsafe` is a great feature! I like Buffer.
There is a inverse relationship between ease of developer experience writing a program and ease of user execution of that program on an arbitrary platform slightly different from the developers. This is taken to the extreme in two languages that otherwise are very similar in origin and use: Python and Perl.

Python is a great language to write things in. It's super popular and always getting new features. But it is one of the worst languages for people who aren't the developer to try to run what the developer wrote. It is just implicitly assumed these days that the system python install simply won't be able to install or run the dependencies the developer used. But it's not just dependency hell of a normal type. In python you need a dependency manager manager (conda/poetry/pyenv to a lesser extent) to set up the container in which you'll use your actual dependency manager in isolation (pip, pypi, etc) to try to set up the depencies needed for the python script(s) to run. An even within the multiple layers of management overhead python changes from version to version (even minor version sometimes) and a python script written 10 years ago won't actually run today and vice versa.

Perl is notoriously not a great language to write (and maintain) things in. It also no longer popular and doesn't get lots of new features. But it is one of the best languages for people who aren't developers to run what the developers wrote. The system perl on your distro will be able to install the dependencies without breaking anything and run the script, usually from disto repositories, but at worst from cpan which is universal. A perl script written today can be run on a system perl install from a decade ago and vice versa.
Which part of the following is not believed by most Christians?

> That God kinda-became human to "sacrifice" himself (with no loss, got up 3 days later to live forever, nothing was sacrificed) in order to forgive the sins of people, but only if they believe it
Agreed.

Most people understand quickly that after a 50% loss a 50% gain is not enough to break even.
This would be interesting.
i love content like this on youtube, i show it to my kids and they just can't believe it. They're still young enough to not question intuition when it comes to math haha. On a road trip once, my oldest ( at the time he was 12 ) tried to convince me for over an hour that he knew how to divide by zero...
Ah, the not-that-kind-of-foreigner, racist way of counting! Some people love to do that, don't they?
Well it is little bit higher that 3k EUR, but for example Hyundai Getz is around 4500EUR, 150k km. USA does not have small cars for small price.
Polyfill Buffer.
I don't know why you seem to think we can only have "super-lightweight 2kb C binary" or "giant over engineered Java-IDE" - there's lots of space in between. I don't think anybody would want to give up snappy terminals, but at the same time, why does this have to imply loosing out on half a century of user experience research??
Funny enough Pieter Spronck has made it onto HN in the past for things other than Space Trader. Guy's a real polymath.

There's a version on Android that's very true to the source material: https://play.google.com/store/apps/details?id=com.brucelet.s...

(No affililation, just a player)
It does a great job of explaining what Twitter did right, but how did it go so horribly wrong? Enquiring minds want to know.
For those in the UK, the BBC did a documentary about a trial involving this therapy: https://www.bbc.co.uk/programmes/m0006nzt

Very interesting.