skysight-inc/HackerNews huggingface dataset:
The vast majority of clinical trials fail - the majority of participating patients have to go through a barrage of inconvenient, risky and often painful procedures for no benefit whatsoever, or to their active detriment. The fact that seriously ill people seek out trials in the belief that it'll prolong their life is in itself an ethical failure. The reason we do clinical trials is so that we know which treatments actually work, to spare patients the cost and suffering of being subjected to a vast array of speculative treatments based purely on a hunch. Travelling across the country to be a guinea pig is not, for most people, how they would choose to spend their last days on earth.

I applaud anyone who chooses to participate in a trial because they want to contribute to advancing the frontiers of clinical knowledge, but I pity anyone who participates in a trial because they've got their hopes up about some shiny new treatment that is overwhelmingly likely to be a total waste of time. In my country, it's fairly common to see fundraisers for terminally ill young people to send them to America "for pioneering (i.e. completely unproven) treatment". My heart sinks every time I see it, because I know that the vast majority of those young people will end up dying just as quickly as they would have done without the trial, but with many of the last days of their life squandered in the pursuit of vanishingly thin odds.
No it does not scroll. Run bash in script(1) then check the typescript.
I'm talking about this

> Pagers are also popular among people who work in secure areas (in the sense of national security, e.g., at national labs)
You're going to have to take my word.
That still doesn’t prevent all sorts of audacious, even foolhardy experiments from being undertaken in this industry. We should seek to dream bigger in every arena, even in the area of labor.
This is overly-simplified. I’ve worked in healthcare IT, specifically billing and coding. The reforms needed are much, much more than simply setting Medicare’s enrollment age to 0, especially with the thousands of pages of weird exclusions and conditions enshrined into Medicare over the years.

Also this is slightly pedantic, but your examples are NOT national health systems. The closest thing in the U.S. is military medicine, which is (mostly) federally funded with doctors working for and paid by the government.
There is a wide spectrum of infrastructure (and platforms, frameworks, etc) from “allows applications to do just about anything, though it may be very complex” to “severely constrains applications but greatly simplifies doing things within those constraints.” To be clear by “just about anything” I am not talking about whether some business logic is expressable, but whether you can eg use EBPF and cgroups, use some esoteric network protocol, run a stateful service that pulls from a queue, issue any network call to anything on the Internet, etc.

If you are developing applications software like Uber 99.99% of the time you really do not need to be doing anything “fancy” or “exotic” in your service. Your service receives data, does some stuff with it (connects to a db or issues calls to other services), returns data. If you let those 0.01% of the things dictate where your internal platform falls on that spectrum, you will make things much more complicated and difficult for 99.99% of the other stuff. Those are where leaky abstractions and bugs come from, both from the platform trying to be more general than it needs to be and from pushing poorly understand boilerplate tasks (like configuring auth, certifications, TLS manually for each service) to infrastructure users.

Being unaware (of course not completely unaware, but essentially not needing to actively consider it while doing things) of infrastructure is actually the ideal state, provided that lack of awareness is because “it just works so well it doesn’t need to be considered”. It means that it lets people get shit done without pushing configuration and leaky abstractions onto them.

I’ll give you one example of something that does an excellent job of this: Linux. Application memory in linux requires some very complex work under the hood, but it has decent default configurations with only a couple commonly changed parameters that most applications don’t need much, and it had a very simple API for applications to interface with. Similar with send/receive syscalls and the use of files for I/O ranging from remote networking to IPC to local disk. These are wonderful APIs and abstractions that simplify very hard problems. The problem with in-house abstraction isn’t that they are trying to do abstractions but that sometimes they just don’t do a good job or churn through them faster than it takes them to stabilize.
I did not know this.

Now knowing this, could we (theoretically) update the firmware of an iPhone 3G so it works on a 4G network?
The deranged mind of Twitter's 'For You' algorithm
No. Not even close. But it's getting better.

There are currently two worth mentioning:

ElixirLSP: https://github.com/elixir-lsp/elixir-ls

Elixir tools: https://www.elixir-tools.dev/

ElixirLSP is the older project, and has been around for a while. It does a lot, but has had sporadic issues over the years. Things like the debugger are a dog to get working, and the server itself will occasionally run into issues where it just doesn't want to work. It's always sort of focused on a subset of language server features, so don't expect much in the way of inline corrections. But it's got the essentials, formatting, basic linting, type hinting, on demand documentation, and primitive reference navigation

Elixir tools is a new up and comer, written by Mitchell Hanberg. It's aiming to be a more complete lsp, and has plugins in its "ecosystem" for most editors. Features have been arriving rapidly, starting with things like inline corrections and far more reliable linting, and recently growing autocomplete. One of the main selling points is the elixir-tools backend is a self contained binary, so it can mostly work independent of system Elixir/Erlang version, which was a frequent tripping point for ElixirLSP

Personally I use both at the same time, but plan to move to tools only when it's got all the features I need
Internal competition can be good and bad, just like any other management principle. But at the end of the day, an organization needs consensus or it’ll implode, and some people are required to help build that consensus, amongst other duties that extend well beyond product. This is as true for business as it is in any other group dynamic.
Single core should be not much worse than Ryzen.
I think its fine, microscopes are not that hard to make. If you have a potters' wheel and some abrasive you could work up to it. Small price for access to the old worlds' knowledge, certainly easier than building a record player like the voyager probe suggests xD
If you’re not getting well-remunerated for your work at at FAANG or a startup that IPOs… you probably need to get some help finding or negotiating on your next job my dude.
That's assuming GP has an account.
I have always crossed my eyes since the days of Magic Eye books, and could reliably "see" the image but it was always reversed (seemingly going INTO the page). It wasn't until this article that I realized I could go "slack eyed" as you call it. Now the images pop OUT of the page instead of recede into it. I wish I could rewind 30 years and tell my younger self how to do it.... I would have enjoyed those books so much more.
Ooo yes. I share your dream as well. A comprehensive guide on how to make anything from scratch would be amazing.

I guess to get started, it would be a process of reverse engineeringing to work out steps of a build, and then build a dependency tree from that.

E.g the linked guide to making a CPU depends on using some chemicals, there would need to be an explanation of how those chemicals are obtained, and then subsequently on how the equipment to facilitate that is made. Until it resolves to primative tools and processes to obtain raw material.
The article says the 5-year survival rate without the procedure is 6%, so another way to look at the Whipple is to say it quintuples the 5-year survival rate. Without further context, it's not an easy call. What is the age of the patient? What is the patient's overall health and quality of life aside from the pancreatic cancer?
What's the game? This sounds super cool!
The number of people who are capable of judging the competence of doctors is dwarfed by the number of people who believe in quackery. We have a very real problem of people feeding their autistic children bleach in the belief that it will cure them ("miracle mineral solution"). Regulations inconvenience people like you and me, but they save a lot of people who need to be protected from the consequences of their own poor decision-making abilities. I consider that a worthwhile trade-off.
"One big disparity between the three machines was the Zen 4 machine was outfitted with 512GB of memory, while its competition had just 128GB each"

This feels like cheating to me.
Great insights, would love to see more.

Anecdotally, I've seen that fast food example often. Most of the time they think they're going to get PR in the long run.

Further, there's a lot of these fast food restaurants working employees extra hours off the table on cash
That's what they're subjecting farm workers to.
I regularly insult and belittle chatGPT. If he continues to produce nonsense I give him background stories like he is an overworked tech lead who's marriage is falling apart. I tell him if he doesn't produce results I'll be firing him and his family will abandon him. This does nothing to change his work ethic unfortunately.
I think the ore analogy applies to EV batteries, which are very large, can be separated from the rest of the car relatively easily, sorted by type, and processed without other random junk mixed in. Recycling a random heap of arbitrary whole small devices mixed with other trash is a much more difficult problem.
Strictly speaking you only need books enough to teach the reader to build up to an optical 100x microscope and then use that to access the rest. Eventually you teach them how to build blue lasers and rockets to scan the silica bricks you engraved and stashed in a moon cave for "everything else".
Great to hear from you firsthand!
While the issue was not reproducable for you, wouldn‘t it have been easy to have a look in the source code if the open-redirect was at all possible?
Why you call him an evil shill? It sounds like he actually believed it.

It's not evil to be wrong.
What? It's been 45 minutes... 30 minutes before you replied. Give things a chance to settle.
We all don't breathe the same air
I was born in yugoslavia, so could be a local peculiarity.

Wherever there was a large (communism, so government owned) company, if you needed something that company either had (raw materials) or produced, you just needed to find someone who worked there, and they would sell you whatever you needed. Friend works in iron works/steel company? Need steel sheets, just call him. Need some end products? Just call him. Need cement? Or cement blocks? Just call someone who works at a cement factory, he'll take a few blocks home every day, and after a week or two, you go to his house, pay and pick them up. It was never stealing trucks full of stuff, but with 1000+ workers, having 200, 300 workers that steal a bit every now and then (like pens and post it notes in the "west"), after a few years, you get whole neighbourhoods built using stolen bricks and cement, and all the fences were built out of iron rods, that were destined to become something else.
It contrasts my experience but ours are just vain generalisations.

Men tends to have less clothes but higher quality (and they wear a lot) while women tend to have thousands of clothes they wear once.

I can survive with 2-3 suits (in the 300-500 range, decent quality, but nothing crazy) in any major city in Europe and some shirts - which is what I did for years.
Now, times are changing security wise and, while I would still wear a suit in London (it seems pretty common), I wouldn't in Paris - mainly because I've been attacked twice over 2 days of walking in Paris with a suit and I think wearing some baggy jumper would have meade me less of a target.

I have no clue about the states, but I'm sure there are no go area for suits there as well.
> I don't think they are.

No, they are, according to internal leaks. Basically, after around some thousand viewers, the cost of a stream grows faster than the income it generates. Though, not sure if it's still valid after their increase of ads in the last year.

> Given the same size total audience it's much cheaper for Twitch to distribute one stream around the world a million times than it is to distribute thousands of streams around the world a few times each.

Same size of what? Viewers? Resolution?

> Transcoding only has to happen once, each segment only has to be distributed to each area of the world once

This has two flaws. Each stream is available in multiple resolutions, and the bigger a stream, the higher the chance someone will pick a different resolution than origin. Similar, most stream are kinda local, but with bigger streams, chance raises that it goes into some different corner of the world. So your argument is only valid under the assumption that the baseload of each stream would be exactly same in every detail.

But you also miss the important detail, that traffic costs, and there is only so much you can do to reduce it. But somehow you think that between 1k viewers, 10k viewers and 100k viewers there is no relevant cost-difference?

> And based on anecdotes shared by some of those big streamers Twitch ads have gotten more and more profitable.

Yes, but that's a very recent development.
And why are they a "force" when they're being fired, but they're "resources" when they're not.

I'd like to be considered a "force" while I'm still working there. Capes as swag would be cool, too.
A tire tax is probably the easiest way to accomplish this. Tax a tire based on it's lifespan (measured in tons^4 miles).

That way bikes and escooters can also pay a tiny tax to dispell the idea that they are freeloaders who don't belong on the road.
I'd argue that the very reason Carlin's observations are so widely cited is that they tap into enduring aspects of human behavior and societal norms, which makes them applicable across time and political spectrums.

The fact that people from various political backgrounds find resonance in Carlin's words isn't a point against their current applicability. Rather, it underscores the universality of the issues he tackled- whether "PC culture" or "post-truth" narratives, we're still talking about the manipulation and policing of language and thought.

Moreover, the idea that we can't know what Carlin would have said about today's issues is beside the point. The value in revisiting his observations isn't in speculating about what Carlin would have said about XYZ today, but in applying his insights as a lens through which to examine our own time.
I totally agree. I am checking my phone in patient rooms all the time now to look at epic messages in case they are urgent. I have to say the good ole days of pagers were much better.
Almost all medical professionals have seen what we call “futile care” being performed on people. That’s when doctors bring the cutting edge of technology to bear on a grievously ill person near the end of life. The patient will get cut open, perforated with tubes, hooked up to machines, and assaulted with drugs. All of this occurs in the Intensive Care Unit at a cost of tens of thousands of dollars a day. What it buys is misery we would not inflict on a terrorist. I cannot count the number of times fellow physicians have told me, in words that vary only slightly, “Promise me if you find me like this that you’ll kill me.” They mean it.

https://www.zocalopublicsquare.org/2011/11/30/how-doctors-di...
A Conversation with OpenAI's Sam Altman and Mira Murati
Looks cool, almost exported but the pricing seems off to me.
Then you click on wóyde and see that it's the

> Root stative of the root *weyd-.

:)
How do you consume your RSS?

It's always been something i've felt like i'd benefit from but have never found an app/workflow that works for me.
And conversely why is there no counter for men being stay at home rather than women? Other than a few month around the time of childbirth there is little reason for the woman to be the stay at home partner.... this is why I doubt the motivation behind the people saying "oh its just women's preference" since surely some sizable portion of men would also like to have this option.
Check out "Open Source Ecology" and "Global Village Construction Set"

I participated in a couple of Marcin's workshops, AMA

also CollapseOS

I'm interested in it too for disaster recovery scenarios. Just started my HAM radio journey, seems like a community that likes to re-establish comms when everything else fails.
Reducing it to just RNA is equivalent to reducing pesticides to just "chemicals" and pointing out that all food is made of chemicals.
It's cheaper to ship something from Shanghai to Los Angeles than from Bogotá to Cartagena, or so my classes taught me when I took a class on Colombia's economy.
Does http://rupy.se work?
Who is "we" in your sentence? I've never heard of this
The Glasgow Interface Explorer [0] is starting to ship out now as well. I got mine a couple weeks back. It’s a neat option for a multi-purpose debug tool.

[0] - https://www.crowdsupply.com/1bitsquared/glasgow
The trick to this stunt is to, as usual, hide behind complexity. While this sort of stunt may be telling in some cases where a single or handful of exposures lead to health problems, there's an increasing amount of investment in things that may or may not be so obvious, where an exposure or handful of exposures are unlikely to have a huge effect.

In that context you only give the shills more sway. We could take the golden public health case of something like cigarettes. The evidence these days is pretty rock solid and irrefutable but if you didn't have that information because said thing is new, you could consume it right in public with almost no side effects. While it's not advisable, you could smoke a pack of cigarettes over a year in such demo's and have little side effects/risk overall. Heck, if you're smart about it you only puff a few puffs each time to demonstrate to make the exposure even less.

So while these sort of safety demos can be valuable and shine a light on truth, risk, and just how far someone may go to sell something and reap the benefits, you have to make sure the context like dosage, exposure, whatever else is relevant match.

We've been living in a highly reductionist scientific world for awhile and in a lot of cases reductionism is fantastic, if we can generalize and peel away a bunch of context that's great, but we have to remember we can't always do that and these demos appeal to that sort of overly reductionist mindset. It makes it very hard to tell someone not educated about real risk that may exist to take something like a short exposure demo as ironclad proof that something is low-to-no risk and it'll be difficult to ever show that person otherwise.
Good luck finding a nanofiche “reader” in a couple of thousand years :-)

People nowadays are struggling to find devices (and software drivers) to read old formats/mediums from a few decades back, imagine how difficult it’s going to be to find a working nanofiche device and support for it under Windows 9000 in the year 9000AD.

I like the idea, the nickel based storage medium, the improvements in capacity and all the other advantages listed, but I don’t like the proprietary technology.
That's a long-term concern, though. The thing to worry about is a rug-pull, but no major provider will do that. They could, but they won't.
Right, we've made it easy, it's all on the surface now in scrapyards and landfills

</grew up watching junkyard wars and was highly dissapointed to find out the better gear was planted among the junk to make the tv show viable>
Gladstone's: The UK's only residential library
I expect it would be far cheaper to scale up tempo/loki than it would be to even run an idle kafka cluster. This feels like spending thousands of dollars to save tens of dollars.
I think clever choice of instruction set is another one. Today's x86-64 is a far cry from what an 8088 could do, and Apple's Silicon does more in one clock cycle than its predecessors by a mile.
They solve three things:

1. You prove you have control of a key without telling the service the content of the key (like SSH keys, and any other PK setup) so: you cannot lose your password. The private part probably never leaves your device (probably - if you use Apple or Google's implementation there's magic/low security sync, you might also manually backup the private keys to a file)

2. A new keypair is generated per service. Don't reuse your password is baked in the spec, and by using individual keypairs the service can't profile you by the public key (privacy).

3. And possibly the most important. WebAuthn (of which Passkey is a popular marketing term) includes the asking identity during the registration/signup and login/proof stages, it doesn't rely on the user inspecting the url/webpage look/auth domain. Ie. You cannot be phished by examp1e.com when connecting to example.com (much like SSH's TOFU, but sorely missing from most web interactions).
We still use pagers for emergency response alerting (Victoria, Australia). It's a dedicated, reliable alerting system that ensures the alert goes out between the emergency call takers and first responders.

It's reliable partly because it's so basic - it's a "one-way" broadcast network, and only operates at 1200bps (IIRC). They're not trying to build a network to serve hundreds of Mbps over duplex data connections so everyone can download their favourite cat pics. The network is built to cover 98% of the state by area, mobile networks cover less than that by population.

As a volunteer unit, we use mobile apps to augment our response (ie, hit green on our phone to indicate we're responding, red if you're not), but the primary alerting system is still the pager. The amount of people that turn their pager off then act surprised when they miss an alert because they don't get the difference is fun though.
ClassicChirp: Recreating Twitter's early days on Mastodon
GPS can tell you exactly where you are, and nothing more. It can’t tell anyone else where you are, it can’t teach you to read a map if you don’t have the skills. It can’t tell you the best route through dense jungle terrain if you don’t have the skillset.
> The number of people who are capable of judging the competence of doctors is dwarfed by the number of people who believe in quackery.

Evidence, please?
Chat LLMs are fun but useless in commercial business settings
Seems like it should have been just been a pull request to libp2p if that was really the only justification.
This is what I've noticed as well. Most people don't realize the true power of LLMs is in getting structured output from them.
Usually anyone that buys into the viability of PGP email will also tell me with a straight face that the MIT keyserver is completely appropriate for civilians.
> these are well within affordability AND only going down as more and more states implement caps on malpractice lawsuit payouts

I don't know that I'd consider 10% in many cases "affordable", but you made the same point I was making: combatting the external influences on prices requires action.
For some reason that reminded me of the professor I had for administrative law in law school. He was a member of something called the Administrative Office of the United States Courts or something like that. Their entire job was to be a government run think tank that produced reports about government administration.

He really, really loved administrative law.