skysight-inc/HackerNews huggingface dataset:
IMHO, Sinclair is making a mistake by taking spermidine directly since it will probably deplete riboflavin (B2) because the excess spermidine will be metabolized my Spermine oxidase which uses B2 as a cofactor

https://www.uniprot.org/uniprotkb/Q9NWM0/entry

IMO, a better way is to trigger your own body to make spermidine by getting enough Arginine and taking Manganese, B6, and keeping your methylation cycle flowing.

The pathway is as follows:

Arginine -> (Arginase, uses manganese as a cofactor) -> Ornithine -> (Ornithine decarboxylase, uses B6 as a cofactor) -> putrescine -> (Spermidine synthase which needs SAMe and Pyruvate) -> Spermidine

https://www.mdpi.com/metabolites/metabolites-12-00344/articl...
The video at 6:11 briefly touches on making mortar and stone construction (along with visuals):

> binding material or mortar should be of the same constituency as the brick
or stone white gypsum and sand mortar go well with sandstone mortar made of lime
clay and sand is suitable for our newly developed mud bricks

https://youtu.be/f_q1pYl80pc?si=sP1GwbWT3UfFVsBW&t=371
> Maybe not excel on its own but I imagine office is already its own org inside Microsoft.

You are correct, it has been its own org for a long time.

I don’t see the decoupling from the rest of MSFT ever happening though. Working with some of the Office codebase and some adjacent ones years ago, it is so tightly coupled on a technical level to many other MSFT products, it is pretty much impossible to separate. At this point, I wouldn’t be surprised if someone told me that there is some level of Xbox code integration within Office, and I am only halfway joking here.

AD integration alone is so fundamental, without it the whole product starts falling apart. Hell, some of the code in SharePoint has hard dependencies on rather ancient Skype/Lync code, and some pieces of core functionality code are still hanging onto files that were last touched 10+ years ago. It was kind of a bittersweet feeling to have to edit a piece of code and reading comments, and then realizing that the most recent changes to it were submitted by your manager around a decade ago, back when they were just starting out their career as a software dev.

And let’s not even talk about Teams, which has its fangs set extremely deep all over Office products (and beyond).
A thought experiment I like to employ when imagining the impact of a new piece of tech: reverse the timeline. If the tech were the status quo, how would the current status quo be marketed?

If moving the camera were the norm, the current status quo would probably be marketed along the lines of "No more micro-managing camera views, arguing over playback speed or fiddling with the timeline – this next leap in technology introduces pre-edited video, where each game is preprocessed by a team of highly-skilled, professional producers, selecting the best viewing angle and playback speed so you and your friends can just sit back, relax and enjoy the game."

If the fictional press release sounds good enough, the tech probably won't hit.

I remember 30 years ago during switching to digital TV broadcasting that proponents of the tech tried to sell a future where viewers of sports events would be able to select which camera to watch. Then again, imagine watching a game with 10 friends and trying to agree over cameras...
From a quick Google search: 1m3 of concrete = 150l water + 250kg cement + 700kg sand + 1200kg aggregates.

Even if you used just cement and water I think you would get more than 12L from 25kg.
There's also many assumptions in the initial m^2 != 2n^2 proof that many would have a hard time instantly grasping. Problem is stated in three different ways, takes quite a bit of knowledge to instantly see they are the same problem.

The proof stops at 2n-m and m-n, subtly, because that is another smaller case of can two squares fit in a big square. If you do the expansion of 2(m-n)^2 and (2n-m)^2 to see if there's a fit, you see there isn't but the proof does not need to deal with that and to me the reason is very subtle, wordy.

Graph theory proofs feel very similar.
It's called (I think) sound design. Changing parameters of a sound wave like filters, resonance, envelope, cutoff, etc, you can achieve desired sounds (you can do that using a real synthesizer or a virtual one). In this case they're explaining how to make a bass sound (which is in the lower frequency of the spectrum)
I did some contracting at a bank and an employee told me about a problem they had with their pneumatic tubes: A customer had taken the carrier with them when they drove off, so the teller put their spare into the tube and continued working. A short while later the customer realized they had absconded with the carrier and returned to the drive-thru and put it back into the tube. The next customer put their deposit in the carrier and sent it off - the teller received it and said "Sir, there's nothing in here." and held up the empty carrier to the window to show them. And sent it back. The customer took the carrier out, held it up to show his documents in it, and sent it back into the bank .. only to arrive empty again. They eventually figured out there were two carriers in the tube.
> I know Microsoft Word is disliked around here, but I regularly produced complex documents hundreds of pages in length both by myself and in collaboration with others. I found it to be a good tool for doing so.

Anyone who doesn't think Microsoft Word is now on-par or superior to every other word processor in ability and function, tells me they have no idea how to use.

Part of that is Microsoft - Word is extremely complex with, literally, hundreds of options, much of which you need to be actively taught (a high quality book or a long course) - the other part is that it's user interface is still very much rooted in earlier computer design ideology. It has to be.

This kind of reminds me of the people who complained that Maya was so much more complex than KPT Bryce. Yeah... it has to be. One of them is almost unfathomably powerful for creating computer-generated graphics, and the other displays its limitations well within the first hour of usage.
> You don't need a systemd unit to keep your server running

You do, actually. You need a systemd unit to keep your apache / nginx + fpm / whatever server that is actually handling and processing your requests.

Edit:

> You could use Ansible to deploy your PHP but you can probably just use git.

You can use Ansible to deploy your [Python | Ruby | Perl | JS | Java | literally every other language on earth]. I can't see your point.
Comparability between implementations: Say GPU vs CPU, or between languages, or to pseudocode in old papers.

Typical example where the badness of the floats bites you is if you do something like log(rand()), or 1/x, or more generally you map your uniform (0,1] interval via a cdf to generate a different distribution, and your mapping has a singularity at zero (this is like super standard -- e.g. how you generate exponentially distributed numbers. Or if you generate random vectors in an N-d ball, you're using a singular cdf to compute the magnitude your vector, multiplied with a normalized normal distributed N-d variable to generate the angular component).

Then the bad random floats (i.e. the non-smooth distribution close to zero) introduce real and visible bias after transformation. Afaiu the problem is well-known and serious people correct for it somewhere. If you fix the underlying problem without revisiting the now-obsolete fixes, then your results are biased again.

I'm not arguing for keeping the bad random float generation everywhere. I think it should be fixed, not just in julia but everywhere. I'm just saying that it's not a no-brainer and there is discussion and compat and communication and code audit involved in doing such a momentuous change.

Also, I'm not really up to putting in the work to champion that at the moment (arguing on the internet doesn't count ;)).
Boston doesn't have any old stuff.
Along a deep 50/50 split?
Conan indulges the fantasy that c++ code is packageable. Sorry, in 2023 the only portable way to distribute c++ libraries is still by source. This is why header only libraries are so desirable.
Founder personality could predict startup success
We are launching on PH tomorrow. All the support is appreciated
The screen readers can say the number of indentation.
They also apparently communicated the need for a hot caffeinated beverage with the sequence 418. It is unknown how the receiver of this code would communicate their intent to fulfill the request, leading historians to ponder if sending such a signal might result in a torrential flood of the beverage.
Also spoiler - there are no terrorists. It's the incompetence of Central Services that is causing things to explode.
Very interesting. Do you have a website with ideas or pictures maybe?
Good point. I mostly buy fiction or self improvement/productivity books. Technology can work if it’s not application specific like a book design patterns for software.

if it’s about how to use MS Word, a google search or youtube video will probably tell me what I need to know.
Is there a documented best practice for doing this with the MPL?
Airbnb Is Broken
They establish continuous occupation by the same bloodlines, I asked what the definion of country is - there's oral history and law going back along with the paintings.

Bear in mind passports are only relatively recent objects.

Also worth pointing out the British tried that "I think you need something more" line with Terra Nullius .. and their own legal system ditched that as rubbish:

https://australian.museum/learn/first-nations/unsettled/reco...
Arguing over the origins was completely orthogonal discussion to figuring out how to mitigate spread and severity, and I think most virologists made the wise decision to stay out of a fundamentally political argument. It doesn't matter if the virus came from the moon as long as we can quarantine and vaccinate against it.

And I'm sorry you feel misinformed, but nothing I read ever suggested anyone was taken by surprise by its mutagenic rate. To the extent experts thought it might be a "two shots and done" virus, they were overly optimistic about policy and vaccination uptake; were the vaccine manufactured and rolled out quickly enough and deployed globally, it could have been cut off from human reservoirs and died out, but a combination of logistics and public distrust meant we missed that window and now it's endemic. Its mutation rate pretty much guarantees it'll be with us indefinitely as long as the public has the stomach to tolerate that.
Ask HN: Why can't I search my favourited posts on HN?
Favourites are public right? Then why aren’t they searchable in Algolia or the API?
You're probably aware but for anyone not familiar, the economic term you're describing is called "purchasing power parity" (PPP) and I seem to remember that China had more or less matched the US in PPP terms some time ago.

I can say this - as much issue as I might have working in software development, I'm definitely not interested in moving to some other state to work on ammunition presses or whatever it would be to contribute to some foreign war. Even if I believed (which I do) that we are more or less on the righteous side.
> While there is a lot to be said for building codes, I sometimes wonder if the increasing strictness applied to individual homes is a way to ensure nobody has the option to affordably build their own home with their own hands.

I doubt there's a wide-ranging conspiracy to stop people from building their own houses in the western world. I'd rather you not build a rickety ramshackle hovel next to my house. That's why we have building codes. You're certainly able to build your own house, but it can't fall over onto mine, or cause a citywide fire, or be built with poisionous elements, or ...

I recently moved from a house built in 1918 to one built in 1965, and the complexity of the construction is immediately visible. The 1918 wood struction was rough hewn compared to the stuff in my 65 house. All the walls are straight in the 65 house. The 65 house stays cooler in the summer and warmer in the winter. I don't have constant critter intrusion. That's just moving from a 100 year old house to a 60 year old house! The new construction in our area (all high quality - they knock down one of the old 1918 houses to build a new one, no
idea about tract houses) takes the efficiency and performance a level up.

This is all possible through improving building codes - no one would bother with this stuff if it wasn't required.
I recently learned that Hamburg had a big tube system ("Großrohrpost"). The tube diameter was 45cm and the length of the wagons was 1,60m.

Some information in the German Wikipedia:
https://de.wikipedia.org/wiki/Rohrpost_in_Hamburg#Gro%C3%9Fr...

Recent article (paywalled) on German news site:
https://www.zeit.de/2023/37/grossrohrpost-hamburg-kommunikat...
Ask HN: Best Way to Sell a Domain
Does anyone have insight on a good way to actually sell a domain?

I’ve had a four letter domain for many years for a project that I thought I would do and figure I may as well sell it. It’s not a common word, but it is in the dictionary.

I searched and it seems like all the SEO results are kind of useless in that they offer to sell on commission or for some ridiculous price ($100).

I read some old posts here [0,1] but they are 10+ years old and don’t seem to apply too much.

I get probe emails asking to sell abo it 1-2 per year and reply but never get further responses so I suppose it’s people just checking if anyone actually cares.

I’m not sure how to value something like lwei.com to determine if it’s worth selling, or keeping for my long procrastinated project (a micro transaction system as “lwei” means penny in a few African nations).

[0] https://news.ycombinator.com/item?id=4498921
[1] https://news.ycombinator.com/item?id=1836721
> life after a population bottleneck is usually pretty good for the survivors

One example of a population bottleneck I can think of is the plague (black death) in 14C Europe [0]. This contributed to the collapse of serfdom and wage rises, along with significant social change, which was arguably a good thing. But a big difference compared with today is that 'infrastructure' wasn't itself destroyed and existing technologies and raw materials remained available. Food was grown locally, and most industry, such as it was, could continue as before (except where labour wasn't available). A modern war on the scale you are suggesting, killing off several billion people (!!!), would entirely disrupt our globalised society. Reconstruction to pre-war levels of technology and health would be extremely hard if not impossible.

> likely reverse global warming through nuclear winter

Hardly. Nuclear winter wouldn't magically remove carbon from the biosphere, and the disruption of ecosystems and agriculture would be massive.

[0] https://en.wikipedia.org/wiki/Consequences_of_the_Black_Deat...
I disagree. I have had almost no issues with self-checkout, and I use it every week when buying lots of groceries. I think I only had an issue once or twice when the item I was trying to buy wasn't in the system.
> The video talks about "no cost at all", except it ignores the massive amount of labour and time required to hand make bricks from mud and go from there.

That amused me too but I don't see a massive amount of labor.

I do quite intense physical labor. The guy making the bricks is using only one tiny tool. You can do the same with knee pads, using tables, you can put them on plates before you put them on the ground.

I cant see how long mixing takes but say he does 1 brick in 5 seconds. Thats 12 per minute! Say we want a wall 24 bricks wide and uhh 30 tall. That takes only 60 minutes! You.. ok maybe not you... but someone used to the work can make 8 such walls in a day!

When I was 18 I got out of school with a diploma as an electrician. Most kids didn't find a job, I got one because I was just that good. I wire houses for 2.40 euro per hour. My boss charged the customer 25 euro. The houses were sold for roughly 40 000. Today the 40 000 euro house costs about 280 000. My hours are in those houses! People are buying my labor for 73 times my earnings.

I earn a lot more now of course but to buy one for 280 000 at that salary I would have to work 116 667 hours or 2917 weeks 40 hours or 56 years.

Say my salary grew from 2 to 14 euro or 6 euro on average. Then it is only 46 667 hours, 1167 weeks 40 hours, 23 years.

I would have to rent and eat too of course! Say I would have been able to live on only 5 euro and save 1 each hour. Then it takes 135 years.

in 135 years I could make 201 601 440 bricks. Enough for 10 large cathedrals.

> cheap to produce, scalable and durable materials such as steel or concrete?

Cheap as in no matter how hard you work you never gonna get one?

Don't bother with the bricks, just make cob walls a meter thick. It will last until the next ice age.
Probably because a clock is an easily changeable thing, but a schedule or an announcement is less so.

Putting a "Opens at 8:00" on sign on your door involves a fair amount of effort of buying a physical piece of equipment. Changing an appointment may have required walking somewhere and talking to the right person.

Before modern luxuries a million of such tiny adjustments would have required a lot of time and effort.
That's true. I guess I misspoke and wasn't as clear as I could be. What I meant to say was: the problem with Python and JavaScript's module system isn't modules themselves, but top-level statements. You are correct that `import` doesn't solve such a problem; It solves the synchronous dependency resolution problem.

Realistically, that's just what happens when a language allows top-level statements, as they are executed when a file is loaded. As such, scripting languages tend to fall victim to the problem, but compiled ones don't.

I'll update my comment.
That's always been my take.

The first 75% of most of his books are among my favorite recent books.

I've never enjoyed an ending.
Corporate Sustainability Platform
A great tool to evaluate 70K companies in 30+ markets according to the SDGs and new European Sustainability Reporting Standards.

Search by company name or ISIN, & visualise, map or score at the company, facility or portfolio level.
Here are two more:

* The null-coalescing operator is also an are these even valid identifiers-coalescing operator – here $result is 2:

$myvariable['x'] = 1;
$result = $myvvvvariiiiableee['x'] ?? 2;

* '0e123' == '0e456'
Changed my life, tbh
That's why you gotta always learn what is run/made by whom. The logo is irrelevant...
Agree —- as someone who previously only owned software books for coursework in the early ‘10s, I’ve built up a growing collection over the past 3 years. The quality of book content is generally much higher than blog posts and SO answers, and I’ve never been one for eBooks / PDFs.

Plus, it makes my home office feel more in tune with my profession. I like to see the books on the shelf and leaf through them while waiting for my CI to build.
Knew a person who was severely sight impaired who was fond of C.

Can't find it now; there was some online interview of them. They maintained the SlashNET custom ircd for a bit.
I know it is in bad tone on HN, but did you read the rest of my comment? Asking because the part about the media was just one small piece and, imo, the least relevant point out of all that I’ve made.

And I’ve never said anything even close to resembling “both sides are the same.” They are not. But they are both contributing to the whole tearing things apart issue, just in very different ways.

> Why bother even voting?

Because I believe that voter participation is vital to preserving any semblance of a democracy.
I have been told it loses money by Google employees. Not just sensors+compute. R&D and the map-making are substantial costs. Waymo is reported in “Other Bets” which had $1.1 billion in revenue in 2022 and $6.1 billion in operating losses.
Most of the sin of iostream is having a humonguous overload set for operator<<. AFAIK it's not too bad to just compile the stream headers, but the overload resolution for `std::cout << anything` is expensive.
Using the knowledge that they don't have ?
Go forbids cyclical imports, and, in most cases, I really appreciate it. Makes the code much simpler to reason about
Ask HN: How do you keep up with your shortcuts?
What do y'all use for learning, remembering and practicing shortcuts for your digital tools?

I've found a couple of great tools I want to work into my productivity stack, but I struggle to learn all the shortcuts while also remembering shortcuts for old tools.

I know super detailed keyboard setup and macros are one way, both physical and digital - thinking stuff like Elgato's Stream Deck, but also tools like Hammersmith.

Old school is printing out shortcuts and putting them near your mouse, or on your wallpaper.

Ooooooold schools is sticking to vim and bash/zsh, but I'm not quite that skilled ;)
The US (New England) town I live in calls them bylaws.
AirBnb is a great idea. It's sad that the hotel lobby didn't want it encroaching on its business. It's almost a parallel to the Taxi unions and Uber/Lyft.
Short answer is that all parties involved (the State, the Employers and the Employees) want this particular type of cartel to be treated differently from other cartels. The government could change that at any time by passing a law, but they don't because it would be wildly unpopular with everybody.
> The moral to this story is, use what's local and does the job

The content of the video is specifically directed at people of the developing world:

> this is the catastrophic reality I say in developing countries we have to go back to using natural building materials. historically we have a very rich examples of vernacular architecture that still stands we have to go back to our
traditions to learn from but in the same time keeping up with the immense
scientific progress so that a person from the 21st century can enjoy modern
life commodities examples from South of France and Germany
There are only 808k people in SF https://www.census.gov/quickfacts/fact/table/sanfranciscocit...
Also taking us back to 1990's, anyone coming from Object Pascal, Smalltalk or Common Lisp would feel right at home with iostreams architecture.

As for the header bloat, fear not, import std; for the complete C++ standard library, is faster than a plain #include <iostream>, as per VC++ team measurements.
Sophgo Sophon SG2380 RISC-V (16 x SiFive P670) announced
Been in a rut and burned out. Here's what has been helping

1. Exercise, keeps my energy up.

2. Wake up at the same time (helps me fall asleep at night)

3. Make a plan the night before for 1 thing I want to accomplish the next day.

I also found the book Feeling Good by David D. Burns MD helpful. He has several ways to retrain your inner voice to recognize when you're self sabotaging.
What if the municipality allowed them to squat on the landfill, and then 10 years later they all get cancer from PCBs or whatever that were in the landfill? Perhaps we have rules so people don't do stupid shit like build a house where people threw their garbage.
Various Canadian governments have tried UBI and all of which have failed and shutdown the projects. Notable ones continuing are resulting in poverty.

Most recent UBI by the federal government resulted in 400 billion in debt for the government. More debt put on the books then virtually all previous prime ministers in history. Tremendous inflation breaking the trend for decades.

In this case, it's an old pre-inflation private member bill with little chance of it being passed.
And also, for whatever reason they decided to go with the Jag I-Pace, which starts at $72k
Are researchers acting as result couriers? Your responses come across as very daft and fighting for status quo of everything as it relates to virology research.. why?