First off, thanks for mentioning Karl Popper and the media literacy theory. Will have to look into that. I wish you the best here.

Have been thinking about the issue as well and have been drifting more and more in the direction dealing with human error / aiding human thinking by just raising the bar abit without trying to find completeness and focusing on acceptability. Fixing the stuff that should be easiest. So looking at the description of errors and and how to communicate them in a sensible way. A minimum consensus based safety focused approach with capsuled complexity seems to be the way to go.

A few perspectives you may or may not have heard of and find interesting in this context. In the spirit of capsuled complexity and accessibility with good podcasts / videos:

Example for the concept and power of capsuled complexity with the 5 level explanation series from WIRED https://www.youtube.com/watch?v=raHM3k-uR0E

You already mentioned information pollution so you might be familiar with the whole military perspective, from operations in the information environment / cognitive warfare, Diss/Miss Information and missing context, psychographic advertisement, ODAA Loop and the research coming out of IBMs Watson by Juliane Gallinas with her Ted Talk about "(General)Patton in a Box" https://www.youtube.com/watch?v=NOQkPNlTTBY https://www.youtube.com/watch?v=-rg7uKsWlGs
If things shift into a game theoretical perspective its also always worth while reminding people that even psychopaths like drinkable tap water. There is some win-win stuff.

(Air) Accident investigations and crew resource management for how to design processes dealing with human error. Mentour Pilots youtube channel or the series https://en.wikipedia.org/wiki/Mayday_(Canadian_TV_series). https://www.youtube.com/watch?v=PhO-87wwLJs about https://en.wikipedia.org/wiki/Eastern_Air_Lines_Flight_401 for example

Taiwans gov0 (zero) is an approach of consensus finding in politics. Outer alignment is also relevant here. I generally find totalitarianism (corrupt dysfunctional systems) a useful frame of mind in terms of why consensus finding has giant benefits. Joost Meerloos "Rape of the mind" has a good description of how these systems become dysfunctional. Also https://sproutsschools.com/bonhoeffers-theory-of-stupidity/
Noble lies and the problems in how to deal with them are also noteworthy here.

Hostage negotiator are a in hindsight not so surprising great source for consensus finding mechanisms and mindset. https://www.youtube.com/watch?v=8EguLJgkc54

Tim Urbans echo chambers vs idea spaces

You mentioned epistemology, ontology in computer science is a great counterexample for the dangers of aiming for completeness as well as Humes guillotine.

You might also like the stuff from Daniel Schmachtenberger on the sense making crisis. But i always feel always bad about recommending this since its hours and hours of videos. But from the types of information pollution to mementics to a description of the everything crisis we are in through the frame of finding a third attractor its quite valuable. https://www.youtube.com/watch?v=7LqaotiGWjQ

Tristan Harris might also be relevant for how technology (like social media and AI) is causing problems due to humans interacting with it. https://www.youtube.com/watch?v=xoVJKj8lcNQ