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I am not. From what I have seen of YouTube, comments are vile, and mostly there are two strangers posting pointless arguments about something equally pointless.

For me, YouTube is good for watching videos. If I want to discuss it, I post it on FB.
This is basically a neat hack - Cancerous cells use a certain Chemical marker to stop being attacked. This researcher blocks this marker from being used thus allowing the body's immune system to attack and destroy the Cancerous cells.

This is very promising research indeed but while they have shown Human Tumor Cells in mice shrinking, they have yet to show Human cells in Humans shrinking. Should make for a very cool Phase-1 human trial.
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I personally think the chances are high that humanity will simply self-destruct before it can achieve anything like this.
I agree with most of what you said, but for cancer drugs the adverse events are usually less critical for the development than for other drugs. Usually you conduct Ph1 in cancer patients instead of healthy volunteers for other therapeutic areas. Survival is the endpoint that matters, and adverse events are more regarded as a balance between risk and benefit for oncology. You would not accept the same kind of risks for a central nervous system drug, for example.
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I'm not familiar enough with CD47 to know where else it is expressed, but I'm wondering what the "regular" use of CD47 is. Since it's over-expressed in cancers, I'm assuming the cancer is somehow mucking up the regulation pathway for CD47 and there are regular non-cancer related functions for CD47.

The trick to making this work will be hoping that blocking CD47 on healthy cells isn't particularly lethal (in humans), or getting the antibody to target ONLY cancerous cells.

edit: From the paper, it looks like the mice weren't unhappy with the antibody floating around -

"Importantly, the therapeutic anti-mCD47 [antibody] produced no unacceptable toxicity over the course of the experiment, despite having spread systemically. These experiments were analyzed at the end of the therapeutic regimen; acute infusion of these antibodies led to a short-term anemia."
The odds are incalculable, see previous discussion here:

http://news.ycombinator.com/item?id=3662890
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> Even so, does that mean he can't continue using the concept without fear of legal threats?

Yes. To top it off, patent filings aren't made public immediately. There is a substantial delay (I think something like a 12 to 18 months, but I am not certain of that). Just one more way the patent system is a crazy, Kafkaesque mess.

Personally, I think independent inventions in the period between filing and disclosure should be considered prior art (or as evidence that something was obvious and/or "in the air"), but that's not the law, sadly.
I keep seeing this, but have you looked at Facebook's API? What do you feel it's missing, because it's pretty darned open, just access controlled (as it should be).
While it's pretty clear when you are upvoted on agreement, you could at least leave a short comment or reason why you down voted someone. Feed-back, positive or negative, alsways helps a discussion and is, at least as far as I am concerned a question of politeness.
In USA, maybe. Depends on the implementation. I think there is a room to copy the functionality without breaking the patent (I haven't see the app). There's also a possibility that the Google has some sort of agreement and can use that patent.
well designed flow... seems like another competitor to yipit.
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Here you go: http://www.ncbi.nlm.nih.gov/protein?db=protein&cmd=link&...

GenBank for CD47: http://www.ncbi.nlm.nih.gov/protein/AAH37306.1

(Should be obvious, but this is woefully incomplete in terms of where CD47 probably actually appears. But can be a good first place to start.)
inspiring post... great tip for startups, listen to your feedback good or bad positively.
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There's also a Clojure interpreter for Android devices (including tablets), which I think has potential. Unfortunately, it is currently slow and tedious enough that it isn't good for much more than "Hello Lisp!" sorts of exercises.
Random downvotes are a fact of life on HN, if for no other reason than the close proximity of the vote buttons (I know I've accidentally down-voted more than a couple of stories over the years). These things tend to correct themselves if you're patient and wait a few hours.
zed shaw's peepcode one on one goes into something similar. By hooking into the make command, he builds up a nice stats database of similar information
I attended Dr Weisssman present this work a few years back at Dana-Farber. The somewhat long tl;dr is that while immune cells kill foreign material, normal cells have "don't eat me" signal, CD47, a cell surface marker. Cancer cells also have CD47, the "don't eat me" signal, which helps them evade the immune system. So, blocking CD47 would cause the immune system to naturally target the cancer cells, with minimal side effect.

Weissman's lab has an excellent scientific record so this is as good as it is going to get. The challenge now is to see if these dynamics work the same way in humans.
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Let's be fair, people up-vote the stuff they like/agree with whether it contributes a lot or little. Symmetrical actions in UI should do symmetrical things, how hard is to grasp it? Something I like/agree—up-vote. Something I disagree—down-vote. If you want different behavior then remove down-vote button. There is "flag" if one thinks comment is inappropriate.
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Why don't they just keep increasing the price to insane levels and see how deep the rabbit hole goes?
Sure, that's basically the point of WebM/Theora. The goal isn't to make a better video format, but to make one which allows free sharing of videos.
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Stealing and theft is often used to refer to things that are not stealing or theft in the legal sense. This is especially prevalent when talking about ideas and designs. The speakers usually do not want laws to change, they don't want to sue.

You cannot take the use of such words alone as an indication. That just makes no sense. Stealing and theft aren’t legal terms, not first and foremost. They only happen to also refer to legal concepts.

No irony nowhere.
It turns out the first paragraph in the paper gives a good indication for me – it's pretty much all over the shop, which makes the lack of toxicity here pretty interesting.
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Ah, that could be a reason. Again, no offense taken, I just wondered.
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Kill the cancer. Leave the normal tissue alone. C'mon scientists how hard can that be.

/s
You prepend 'js-' to a selector, not append it. Otherwise you'd end up with 'my-thingjs-', which is weird.

Also, no semicolons, yey.
Coffeescript, boo.
I've been using Session Buddy (www.sessionbuddy.com) for a few months now. It (optionally) automatically indexes your open tabs during a browsing session under their respective windows. You can go back later and label or augment these sessions with further browsing. This isn't exactly what you're asking for obviously, but you may find it useful anyways.
The part about "Faking Data" is quite worrisome.
I think they've totally hit the nail on the head. The problem with G+ is that the profile page and wall felt like blatant FB ripoffs so no one used them. Everything else in the Google space was and still is widely used. It's just that now Google has to embarrassingly acknowledged to its users that it tried to be FB, failed.

Perhaps more importantly G+ has eroded user trust of Google because it made people come to grips with the amount of data Google has about them in a way they could before just not think about.

And perhaps most importantly, Google has finite eng and user experience resources and instead of them being devoted to Google's many other products (many of which are not finished or ready for go-time with enterprise customers), they were sucked into the G+ black hole because it was the hot new thing. Too bad most of their work was in vain...
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If you see it like that, you're right! I rather meant the fact that the green turned into yet another mainstream party with the same political infighting.
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I doubt it will be possible to recapture the golden age of early PC's and their ability to get kids programming. The computing landscape has changed, and educational practices must change with it. We have to assume kids will have ipads as their first computer and treat them accordingly.

Kids these days are web users first and foremost. You have to let them cross the gap between visiting sites and creating sites. There's plenty of opportunity for sites that let kids create stuff in javascript and share it with their friends. What's so different from animating a canvas using javascript and animating a tv screen using basic?
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There are several differences. Firstly it's only triggered when you pull past a certain threshold, and secondly it refreshes all new items - not just the ones that cover the uncovered scroll region. It's also cancellable before you reach a certain threshold, and clear feedback is given about this.

Regardless of where you stand on patents, this is certainly not the same as infinite scrolling.
If @vjanma has a concrete way* to prove that his design is in the same timeframe as Apple's then they could challenge the patent application. The patent application is not a patent yet. So talk to a patent lawyer.

*you do have an application in the app store. But you may need much more documentation to challenge the patent.
cool,thanks.I'm not aware this documentary.Will watch it soon :)
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More worrying is the fact that when downvoted too much, your account gets 'silently banned'. Also if you post anything critical of YC companies this tends to happen.

Behind the scenes, many accounts are silently banned, and many comments are removed if they don't sit well with the powers that be.

If you're pg and you disagree, you don't downvote, you just remove the comment you disagree with.
The trouble is that there are many, many different ways that a cancerous cell is able to be cancerous.

A malignant cancer cell has generally had upwards of 7 mutational events that directly enable it to replicate itself enough times to form a tumor and become damaging.

These mutations includes things like breaking programmed cell death (apoptosis) pathways (e.g. P53 mutations), increases in anaerobic glycolysis (due to lack of oxygen within the micro-environment of a tumor), increasing production of angiogenesis related proteins (to create new blood vessels to the tumor so that it can continue to grow).

Cancer cells even acquire mutations to the pathways that regulate DNA damage repair and replication so that further mutations happen more easily, providing more variation in the clonal colony of cancerous cells making the "cancer" more able to withstand changes in the tumors environment (e.g. the introduction of chemotherapy, hypoxia, etc). Essentially the cancer evolves over relatively short periods of time.

In other words, this is just one pathway that there is a chance we may be able to disrupt, but it may very well be a crucial one. If we can build up enough drugs to target the specific mutations that make some cancers so aggressive, then we stand a good chance at significantly reducing the mortality of cancer.

Excellent research, but we have a long way to go still.
Flagging a comment can get the entire account banned, so use that option with care.

Also, there are more important things to consider than an OCD-fueled (yes, this affects me, too) obsession with UI symmetry, like overall discussion quality.
There are priceless things, but for the rest, money represent the ability of humanity to communicate and exchange economic value so I often think about them as a symbol of what we've managed to achieve since the ancient times. And just like we evolved to exchange promissory value on a piece of paper, humanity made huge progress in self-governance and mutual respect. From the dawn ages of absolute kingdoms we've evolved to constitutional monarchies and democratic republics. We've abolished slavery, enabled universal voting in most parts of the world and probably in some decades almost everyone will have the right to marry the person they love.

Alan Turing was among the most brilliant persons of his time, yet in his society he ended up injected with estrogen, which left him impotent (he also developed breasts and one year after this therapy he used cyanide to kill himself - http://en.wikipedia.org/wiki/Alan_Turing ). If you're in UK, please sign this petition. It would be a huge honor to have on the very symbol of economic exchange Alan's face - a memory of our wrong-doings and of the progress that we made until now and the one that is yet to come.
Disagreement is a key component of an interesting discussion (well sometimes). Down-voting as a short cut to contributing to the discussion is pretty childish - if people do not care enough to make their point in words then they should totally refrain for participating.

I trust HNrs will reserve down-votes for off-topic, rude or spam comments.
You're correct. It just means BATS is processing a lot of orders. I'm guessing LIFFE, LSE etc process far more. The articles conclusion is comepletey erreneous - this has nothing to do with HFT.

Edit: And wrt to retail investors "competing" agianst HFT - they're not. A retail investor is not interested in expoiting very short-lived pricing discrepancies between different contracts (or perhaps the same/equivalent contracts that trade on multiple exchanges). A retail investor is just that - an _investor_ - who holds the stock.
Another one I recommend, because it starts with codegen and works its way back:

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No no, the correct amount of views will be recorded for a specific video, it's just that each webserver doesn't know the exact number all the time. You make each webserver fetch the correct value perhaps every hour, and fake it inbetween. You'll get an ok approximation, users can't tell the difference, and you don't have to fetch the actual number every single pageview.
Slashdot got this (nearly) right. You select from a list of moderation options like "Interesting", "Informative", "Funny", "Off Topic" etc.
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One of the first things I did with out PET-2001 was to solder a switch to pin 40 ;-)
What I find interesting about this question is that it is at once fascinating and silly. Fascinating because it would be incredibly cool to have someone like us somewhere out there. Silly because the distances involved are mind boggling, so it is highly unlikely they would ever be able to contact us.

So is there any real difference between they not existing at all and they existing and we (probably) never been able to know that they exist? All we can hope is to hopelessly theorize and write science fiction stories about them.
Can anyone tell me what they mean in the part about the "US/incubation application?" It refers to YC but this is the first I've heard of it.
Hmm, I was thinking more of "sending chunks of AOF" out to a separate, distributed storage (and the RDB snapshot file occasionally). Loading data from network could then be slower than from a disk, but also faster than from a disk, depending on network speed and number of machines to read from.
We have had infinite scrolling - webpages refreshing in the opposite direction (google reader is the first example I saw) for a long time.

Pull to refresh is exactly the same thing.
I like that. We are merely a tool for the navel-gazing of the universe. Interestingly enough, the tool itself navel-gazes about its own utility.
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Are you suggesting that there is no concept of abstract classes and interfaces in languages such as C# and PHP?
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That's the theory... but the gaping hole is that JSON doesn't define hyperlinks like HTML does. Also, I think Subversion tried to make resources discoverable from the root with WebDAV, but it just leads to crazy latency with all the round trips, and everyone agrees it was a mistake.

Any APIs you can point to that actually use "hypermedia" and are successful? Most good APIs I've seen just define a bunch of simple JSON endpoints with predictable URLs.
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Fun party, eh? :)

Also, I think your analysis is spot on. Another way to look at this is that perfection often kills products—people stress so much over getting every single detail right that they never ship, or fail to execute on the overall vision due to overreaching.

In the Plants vs. Zombies example, there are actually 24 different zombies. If they needed to create different artwork and game rules for every zombie interaction with the plants, the project good quickly spin out of scope.

Perfectionists can generally find an angle to criticize any product.
Isn't the whole point of reading comments to get more views on the matter?

If all (upvoted) comments say the same thing, I wouldn't bother to read them.
Making recommendations for investing is legally complicated, unfortunately.

I know what you mean re deals. I've never bought one myself.

How about a daily smarter rather than a dail spender?
I like his teaching style. To get a sense for yourself check out http://nathansjslessons.appspot.com where he covers functions as values, closures, and CSP in javascript.

I dunno about you guys but I seem to spend almost all my professional time programming in javascript these days. This is perfect!
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This was an entertaining and interesting story but at the end of it I couldn't help but feel a bit discouraged: "great so this means I have to go find somebody to mentor me? To fund me? Should I be talking to more potential users about my idea? What if zero of them cream their pants? What if they all do and someone steals the idea... I'm just one guy, two people are guaranteed to finish this faster. And I thought the OTHER guys said the other day not to talk about your idea until you had something visible, and that's been working well for me. What if I waste my time on this and nobody likes it. Etc."

I think it's important to remember there are many ways to start a product and a business around that product. If the approach in the post appeals and works for some guys - great, go for it. Worst case all you lose is some money and time, but for most of us that's NOT the end of the world.

I'm not comfortable going their route because I really believe I have solid ideas that will generate revenue without needing more funding than my savings can provide, and these are my ideas that I don't want to share ownership with anybody else. A mentor would be nice but these ideas are also about my personality, and I've been through too many situations where people with more charisma and experience try to tell me what to do and I give in to their greater wisdom at the cost of feeling somehow cheated... I want to burn my own fingers, for some reason, and that's the route I'm going to take. (I suspect that what will happen, though, is that in the process of burning my fingers I will meet a great medic.)
Thought HN might be interested in this very nice explanation on Cancer and some ways to prevent (to some extent) is shared by a redditor biochemist http://www.reddit.com/r/funny/comments/kb39j/scumbag_telomer...
There's a huge difference between using exceptions and littering your code with a bunch of try/catch blocks. When exceptions are used properly, you see very little error handling code.
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I just like how they invent lingo to cover up their screw-ups. False print? Come on - Now if I want to describe the problem there is a name for it. And they made sure to mention it three times + one in the photo so I will remember it.
This is in line with what Peter Thiel is saying: IT has been taking a lot of attention and talent from the "hard" sciences and it is certainly arguable that major scientific breakthroughs have been getting more rare. During the cold war it was cool to be an astronaut, now it is being the CEO of the next mobile social local photo sharing startup.
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Thanks! Looks like Issue#6 has already been created.
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