skysight-inc/HackerNews huggingface dataset:
Why is it that I've read maybe a dozen articles like this in the past couple of years but still don't see much change in the way cancer is being treated in the wild? Will there be a year in the not-too-distant future when all of these breakthroughs finally hit the shelves?

I realize the answer is "clinical trials take time and don't always work" but can someone please explain the process to me?
Ah. Just a z-index bug, But I'll take care of it. Thanks for pointing it out!
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Lisp Hackers: Christophe Rhodes
Silent disagreement should not stop someone from being heard.
Not a lawyer, but I'm pretty sure you're wrong. It's harder to prove that your work predates something else, but if you can, you still have a copyright on it.
This article, though interesting, is 4 years old (referring to the z-axis as a "recent addition"). I like the technical explanations behind the physics, though!

A less technical, but more recent article was in the New York Times last year: http://www.nytimes.com/2011/07/24/magazine/the-brilliance-of...
Hey, wow, that is a brilliant idea. Honestly we haven't thought about that at all -- ancestry.com is of course a giant, but we always viewed it as a bit divorced (no pun intended) from what we're up to with FamilyLeaf.

I'd love your feedback (and your dad's!) on our site. My dad -- largely computer-illiterate -- is actually sharing with us via email by emailing photos to send@familyleaf.com. They automatically aggregate in our online album.

It'd be great to chat about your research on this family space. Shoot me an email? ajayumehta[at]gmail
Creative Commons Attribution-ShareAlike

http://creativecommons.org/licenses/by-sa/3.0/

* Allowed to remix (create derivative works)

* Allowed to share (copy and distribute the work)

* Share alike (distribution must be under the same license)

* Attribution is required
That is particularly egregious. From the author's perspective the conversation is basically this:

"I'm with you alex, I tend to only use classes when I've got to maintain state, I just use a function otherwise. Here's how I'd likely code this ... <long code example>"

"You're not welcome here."

It takes seconds to say he should have used pastebin, or to point out mistakes or bad practices, or whatever (I'm not sure why he was downvoted, exactly). Way less time than it took the guy to write the post in the first place.
if there are any feature requests, i'm all ears
You know what: Fuck all these apps that are simply telling me the most interesting thing to spend my money on which is horrid consumerism.

You know what I NEED:

An app that does this but for investment: I set a budget per month; it tells me the best thing to invest it in - and takes a small % of the return.

Open up how to MAKE money, not spend it.

In all of Groupon's life i have bought exactly ONE deal from that. I make well over 100K and have no interest in wasting my money on "deals"
> But is that really the best practice you want to teach other programmers?

Apart from using braces for `for` loops, yes.

> Fourfold inline computation?

This snippet

void *dest = blah blah;
void *src = blah blah;
size_t cnt = blah blah;
memmove(dest, src, cnt);

isn't any different from memmove(blah blah, blah blah, blah blah) if you program in C. Introducing unnecessary noise doesn't contribute to code clarity.

> Cryptic variable names like nvtab.nval?

Suggest a better name. name_value_table.number_values? And give me one good reason how is this better?

There is a whole camp up in arms against abbreviating `count` as `cnt`. Though they never told me what issue they have understanding that `cnt` means `count`.

The only issues I have with abbreviations is they might introduce typos if you choose confusing ones. nval, nvtab etc aren't confusing, not by a mile. If you are confused by them, expanding them isn't going to help you either.

> Comments that use deep local jargon (what is nameval, what is nvtab)?

A localized code snippet uses local jargon. If you disagree, I would love to see your suggestions on improving them.

> Defend it all you will (and also downvote just because you disagree, why thank you), I stand by what I said:

Apart from standing by, show us how do you make it more readable. Your complains so far are fluffs.

> The Practice of Programming is a harmful book and cannot be compared to Code Complete which is much more thoughtful and has unspeakably more attention to detail in naming, syntax, logic, programmer's psychology, project scope, everything.

Sounds like Code Complete is programming for people who can't program.
That's a good question. Facebook does work in some families for sharing, but it's limited. Here's what we've discovered:

Young people like Wesley and I that recently left the nest use Facebook solely for connecting with friends. We may post pictures of us at parties, or other stuff we wouldn't want our parents to see. So we put them on specific restricted lists, or we self-filter everything we put on Facebook.

People like my mom really don't care about Facebook-ing. She only has an account to connect with me and other family members. She doesn't want friends on -- she uses it only for family.

There's a core disconnect there. If I don't feel comfortable adding my mom as a "friend", and she only got Facebook to add me in the first place, there's a problem. With FamilyLeaf, we're earnestly proposing that these are totally different kinds of connections. There are different feelings, filters, and motivations associated with sharing with family. And that requires its own network.
That's the problem with virtual currency like this, you have to create controls to address inflation and deflation, and certain groups of people always benefit from this.

I remember another site based around trading books that used a virtual currency, and a lot of the early adopters got free credits to help seed the system, while the late adopters could only get credits by sending books. It created an imbalance from the beginning.

Another issue is dealing with hoarders and retailers, which can damage the button system by putting too much virtual currency into the hands of only a few.
Great work. Looking forward to making more use of this soon!
I liked his Plants vs Zombies anecdote. I've been playing Tiny Tower with my 4-year-old, and he always asks why the construction workers are just walking around on the floor under construction and not building anything.
The correct lesson to learn here is "markets amass when there's demand," or, more simply put, "people will always buy their drugs."
OMFG! Sorry, but this is inane. Boiling it down, he's saying he doesn't have enough self-control to use a decent work-station because he would fill the screen with distractions. It is entirely possible to live a full and happy life without twitter, IM, email, or even (dare I say it) refreshing HN every 10 minutes. The longest time mentioned in his post was 30 minutes - if this is his measure of "flow" time, I'm actually amazed he gets anything done at all.
Even so, does that mean he can't continue using the concept without fear of legal threats? Are patent filings made public immediately, and even if so, does that preclude the use of a similar concept right away?

It's a bit ridiculous that a logical design for a digital teleprompter-recorder could be patented, in a world where new UI concepts can be whipped up and released in a few hours.
Since moving from C# and Visual Studio to Python and Vim, the one thing I've missed the most is VS-level debugging support, where I can step through a script. Is there any standalone, non-browser tool that's equivalent to this?
First, there's a lot of bad science out there. A large part of this is due to the fact that animal models are almost uniformly terrible at modeling real human disease. Second, a therapy may be highly effective but also highly toxic or have other severe risks or side effects, which are hard to tell in preclinical research. The bar here is very high, and trials can easily be pulled over a few "adverse events." Third, it's rare that investigational drugs are used as first-line therapies; so, the patients getting them are usually the ones in worst shape. This can lead to all kinds of problems in demonstrating efficacy. Also, if your drug does get through trials, the FDA looks very hard at who the drug was tested on and can narrowly limit the indications it receives. So, if you develop "promising drug X", and it's trialled on Stage IV glioblastoma patients who express marker Y and are (for whatever reason) over the age of 45 and mostly female, then you're going to be limited to > 45 year old females with Stage IV glioblastoma expressing marker Y, until you can prove safety and efficacy in another population. But the vast majority of drugs never get anywhere near here: they mostly fail in safety or fail to demonstrate effectiveness early on. (An interesting side note here is that many of the signals you look for to estimate your "effectiveness", like size of tumor, don't always correlate to long-term survival. You can have a drug that appears to shrink tumors and patients still dying. It's really common to see good indicators of progress with little or no impact on survival.)

TL;DR: animal models of disease mostly suck.
Edit: added link to show that orders don't necessarily get filled according to time priority ("an order clearly arrived later than ours with the same limit price,
yet it was filled and we were not.")

It's only hypothetical until it happens to you.

Refer to the fleitz's comment about short squeeze. That's an example of orders that don't get filled.

In theory the broker is supposed to borrow shares to allow the trader to sell them short. What happens if the broker flouts securities law and does not follow the rules?

http://www.nytimes.com/2012/03/26/business/goldman-sachs-den...

BTW, non-HFT'ers get consolidated market feeds which have higher latency than raw feeds that HFT'ers use. That's what a major part of the HFT debate is about.

http://www.hftreview.com/pg/blog/mike/read/5317/hft-and-late...

http://www.tradeworx.com/TWX-SEC-2010.pdf [PDF] (refer to page 17, 18)
Great idea - thanks for the feedback!
Ah they've used Ozymandias in the patent! Classy.
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Sounds too much like Password: Swordfish 2.0 to me. Unfortunately I can't access the article right now. For me, one thin gis sure, the cartels aren't stupid. At least the leaders and the heads, that is. Don't judge the organization by the goons welding guns and that get killed.
They are running a multi-billion dollar business, and I'm pretty sure that they know that forced labour only gets you so far in anything more important than packaging (even thats not sure, given the budget they have and mexican salaries). So I think they are rather hiring the best IT-guys they can get along with the best intel-guys they can get. These hackers may not be of the "don't be evil"-type, what after the cartels aren't in that kind of business neither.
That's a good point. One of our batchmates actually sent that to us a few weeks after we started working on FamilyLeaf -- I had no idea. Would be really interesting to talk to them about it.
"You would realy do everyone a favor by keeping comments like that for yourself."
Yeah, you too.
Hi Guys, we just hated using our keyboards and mouse to control music. Especially, when it's in the background or when we're few feet away. We're just in alpha and launched one gesture - we hope to add many more soon. Thanks for your kind comments and feedback!
In the beginner's mind there are many possibilities, in the expert's mind there are
few.

This is because the expert has learned what is important. For example, the too-large zombie arm is irrelevant to gameplay.

Of course, if you have the wrong idea about what is important it is very useful to have "beginner's mind".
This can happen when debugging the wrong part of the code or when an industry is disrupted changing the game (e.g. from efficiency to development speed then back to efficiency again),

BTW: Employing Autism sufferers is an example of division of labour, the essence of civilization. Vernor Vinge examines the benefits of Autism with the fictitious "Focus" in A Deepness in the Sky.
I favor cogent and on topic comments over agreement with my views or formatting to site convention. Even if I think you are wrong, I will upvote what you say if you lay out your thoughts clearly. And I hope when I'm wrong or ignorant but cogent, people will do the same.
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Great points and feedback for us. The app works locally on you machine, so no video data is leaving your laptop. Nothing to opt-out when we're not collecting anything.

It is only available for Mac right now. We will have that info on our site as soon as we can. Thanks!
It is worth noting that he repeatedly used words like "stealing" and "theft" while outraged and those words have strong legal connotations. That at least suggests (but, to be clear, does not prove) that he thinks there should be some sort of relevant legal protection.
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We hope that at some point gestures become small enough that you don't have to feel socially awkward. At some point, in future, we will interact with machines just like we do it with other humans - through voice, touch, vision... we hope to enable vision, and if it is natural then it is not socially awkward. We love your feedback. thanks!
Great feedback. Luckily, entire app works on your computer so, there's not video data going to server. Only thing we track is non-video usage data. Hope that alleviates your concerns!
as far as I've seen the TC articles that make up here, their arguments are rarely thicker than air. The usual process goes like this: I begin to read, come up with their assumptions regarding X,Y,Z (depending on the product) as "facts". I click the little x button and chastise myself again for reading a TC article with the aim of finding some actual content.

Life goes on...
Although you are correct that trademarks and copyright are a different story, the state of events in those is still not satisfying.

A couple of examples:

1. Trademarks - Facebook recently insisted on owning trademark of word "book". Although not 100% successfully, but some companies settled. What next - trademark "luck", "suck" and "fuck"?

2. If I recall correctly copyright is 75 years + life of descendants. So if I (and say 1000 more people) would like to buy/read a book, that was published 15 years ago and was since abandoned by the author, there is no practical way to do so even if people would be eager to pay royalty. The path/copyright ownership for hits is clear, but what about long tail?
Great point. CPU usage was a concern for us, that is why we spent months optimizing it. It right now uses on average ~5% of your CPU. (20-30% when you do a gesture, 2-3% otherwise). Please try the app if you have Mac and send us more feedback, we would love to hear from you!
Wasn't too long, read and extremely interesting. A sincere thank you.

Cancer itself is such a rollercoaster of emotions for everyone involved and these promises and failures of breakthroughs are a sad and ironic parallel.
That's a great idea. We refer to those as passive gestures, and we will enable those in future too. Right now, starting simple and solving small problems first.
Yes, again, it is for Mac, and we are sorry it's not more obvious. We will add system requirements page as soon as possible.
10,000 People Sign Petition to Honor Alan Turing by Putting Him on the £10 Note
I tend to agree that using a down vote to express disagreement eventually isn't constructive. I've seen a number of posts that didn't say anything objectionable or controversial, nor were meaningless in the context of the discussion, and yet were down modded.

My theory is that while the risk of being down modded on HN is a helpful factor in keeping discussions more courteous than on an out-and-out anonymous forum, the same cannot be said of down votes, which are in fact anonymous. As a result, users tend to be more careless or perhaps even callous in the use of down votes. I'm not sure what the solution is though: making down votes transparent might help in creating a bit more discreetness in their use, but might spill things over into flame wars into the comments themselves when exercised. Still, I think it's the total anonymity that causes its over use.
Art of Focus
I downvoted you because I don't agree with you.
I'm also using a Dell monitor connected to my macbook and am very pleased with it, of course it's nothing like a cinema display but it serves it's purpose perfectly so why spend $1000 on an Apple screen when a Dell works just as fine? That's my opinion.
Most probably. THe universe is Big. But it also is Old.

Most probably someone else was or will be out there. Homo Sapiens Sapiens has a currently very short history (~200k years ?). History is 6000 years old (China?). The universe is 13 billion years Old.

Maybe we're late to the party.
Or Early.
Spreadshirt. They're probably not the most cost effective but the quality is good. (American Apparel)
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To corrupt cops?
Nah, there are tools to script that!
> Does anyone have any idea why there would be this much code?

It's the world's 3rd biggest website with hundreds of billions of views and dozens of millions of users, so maybe that's why.

I think it's a credit to Python that a website that does that and has grown in a fairly haphazard fashion only has about 1000k SLOCs.
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First day with d3.js, extremely basic
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The Google Voice app on iOS has a pull-to-refresh feature. Is this patent infringement then?
Time Management: http://xkcd.com/876/

On serious note:

Problem: Help me manage what I need to do and motivate me to do it.

Issue with every possible solution: there can't be 1-shoe-fits-all.

There are various solutions proposed:
1. Have a "done" list - people get motivated by seeing what they get done and feel good about themseleves when they are reocrding what they have done, and feel bad when staring things they need to do .

2. Pair-wise to-do list. Randomly pair a user to a different user and they both use various means to motivate each other and provide means to help each other. This is social interaction and people feel some responsibility to get things done when they have someone to answer to, while others dont want to expose their private life.

3. Bombard the user with notifications on what needs to get done or give user with positive enforcement every hour, in order to motivate the user.

There are 2 issues to be addressed: Motivation and organization. If the data is not easily organizable, user dont feel like vesting. If user does not have anything motivating to do those actions, rather than procrastinating, your system is plain doomed.
Well said. As in some casinos, in the world's stock markets some big players (probably including certain HFTs and hedge funds) take much more of the winnings than small ones, due to information asymmetry or pure competitive advantage (e.g. due to extremely fast trading and advanced algorithms).

The more money is sucked from the market by intelligent arbitrageurs/gamblers, the less there is for small(er) investors. That's a bad thing in itself and also increases the focus on financial gameplay (analysis of market trends and fads) to the detriment of investment (analysis of the worth of companies). Frothy, ever-rising stock markets attract investment away from other markets, usually for poor reasons: the traded companies haven't done anything that would justify such rapid and significant changes in their stock values.

The point of the stock market is not to let the smartest people profit from the rest; it's to allow companies to raise capital efficiently and fairly. If we tweak the rules of the market, by limiting trade frequency for example, we may be able to push the play in the market towards a form that aligns better with this core function of the market.

Finally, I want to reiterate that for a closed population, the stock market is a zero-sum game. Money made is won from someone else, always.

edit: i'd appreciate you mentioning the points you disagree with when you give your downvotes - thanks
Such a well-designed site.
Read: 5 Things I recommend you doing before founding a startup. People need to stop using the superlative, the English language provides nuances like could, should, would etc.
Incubation Program from Dr. Kai-Fu Lee, ex Vice President of Google
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I don't know whether it is new or not, but Apple has patented it.

It is one of the patents Apple has been pummeling Samsung with in Europe, since they implemented spring-back scrolling in a few places. I remember the photo gallery, but I think there might have been another patent involved there. This patent is also the reason that stock Android (and most non-Samsung skins, I believe) flash a light when you hit a scrolling boundary instead of springing back.

Twitter presumably has some sort of license (via the iOS SDK or whatever) to use spring-back scrolling in the iOS Twitter app. However, there is also spring-back scrolling in the Android Twitter app. I wonder if Twitter has a license for that or if Apple is merely letting it go because of their current friendly relations.
> I'm all for patents (bye karma. but keep reading). that's what allow us humans to invent new things and improve our way of life.

Yeah. So the guy who implemented the "pull to refresh" totally did it because he wanted a goddamn patent.

On a side note, I pity the non-innovative free loaders who roamed this planet before patents. It's not like they invented or innovated. How could they, we didn't have patents.
I've been trying to figure out how to keep my money as far away from Wall Street goons as possible. The hit on Goldman Sachs' reputation from a couple weeks ago is the latest signal that Wall Street's job is to steal customers' money, stay away. The loss in confidence will eventually get them, though that will probably just mean they get another bailout.
They kind of proved this from the day one. Interesting documentary on this topic is Revolution OS[1]. It is kind of biased and now very outdated but it is still worth watching. If you haven't seen it and you are interested in early history of OSS I recommend it.

1. http://www.imdb.com/title/tt0308808/
I'm quite new to HN, so I have a question. Was anything wrong on my comment that I'm the only one to get down voted on this topic? I'm not going to bitch around due to that, don't get me wrong, I only want to understand why, tht's all. :-)
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Anyone familiar with these could share some estimate of in about how much time can we expect to hear the results from human trials?
Are We Ready For the Coming 'Age of Abundance?'
we're not talking about copyright law here, but patent law.
Great job David. Quip's potential applications are endless.
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