skysight-inc/HackerNews huggingface dataset:
If you are so good you can achieve greatness by yourself, as a lone individual isolated from others, and that is what you really want to do, then knock yourself out. That is the American individualistic dream after all. However, if you are not so awesome that you can succeed without help from others, or you value teamwork, community, and friendship, then these are good rules to follow, whether working for a large company, or starting your own business.
Good question. I'm an author on both of the new CD47 studies, so I'll try to answer this for you:

1. CD47 appears to be higher on tumor cells than on normal cells. In general, the higher the expression of a marker on a diseased cell versus a healthy cell, the more of a therapeutic window/index [1] that is available for a treatment to specifically target diseased cells.

2. Inhibiting the anti-phagocytosis (i.e., "don't eat me") signal is only half of the equation. There are also pro-phagocytosis (i.e., "eat me") signal(s) that also are present [2] and that play a role in whether, and how well, macrophages, and other phagocytes, can phagocytose a cell. "Eat me" signal(s) also differ between normal and cancer cells, adding more nuance to the situation.

[1] Therapeutic index: http://en.wikipedia.org/wiki/Therapeutic_index

[2] A paper examining a putative "eat me" signal, as it relates to CD47: http://stm.sciencemag.org/content/2/63/63ra94.abstract
How to you focus? Do you also face issue with your focus some time in life?
Have you read Seymour Papert's book Mindstorm?
http://en.wikipedia.org/wiki/Seymour_Papert

You might be on to something there.
Wait, how is this claim extraordinary? There's a proposed mechanism that doesn't seem to contradict anything we had previously thought we knew about biology, its not like researcher is claiming that he's found evidence for Lamarkian evolution or something.

We ask for extraordinary evidence for claims that are in and of themselves extraordinary. Simply having extraordinary implications doesn't warrant needing extraordinary evidence, though we should always be hesitant to rely on one person's experiments whether their claims are ordinary or not.
Interestingly, you have compared apples and oranges: "lawyers" and "good developers" (as opposed to "good lawyers".)

What I mean to say is - and, of course, this is all unsubstantiated - there are plenty of coders and lawyers to go around, but fewer good lawyers (with relevant experience in a field of business, for me it is the wine biz) and good developers (can you follow the instructions on our code test?)

Possibly good lawyers simply get paid more than good developers, and so that - combined with a different culture between the two professions - engenders a different sense of professionalism.

What is the essential quality about dev which causes our culture to be different than other professionals (lawyers?)
Joel Spolsky's illuminating screed on Netscape rewriting its browser from scratch is apropos here:

The idea that new code is better than old is patently
absurd. Old code has been used. It has been tested. Lots
of bugs have been found, and they've been fixed. There's
nothing wrong with it. It doesn't acquire bugs just by
sitting around on your hard drive.

http://www.joelonsoftware.com/articles/fog0000000069.html
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Which is pretty depressing in its own right.
Closest book I've found on the "no speed limit" approach was Tony Robbins' “Awaken the Giant Within”. It could have just been the timing of when I read it. Tim Ferriss told me the book that changed the way he saw the world was “Maximum Achievement” by Brian Tracy, but when I read it, it seemed like conventional wisdom. So maybe it's just timing.

What I liked about Tony Robbins' message was this:

* - Change happens in an instant. People act like change takes years, but really it's almost always a key moment, an instant where you change the way you think about something, or make a promise to yourself to change the way you act (even though it feels strange at first). It may have taken years of procrastination to get to that pain point, but the change itself is instant.

* - You can change the way you think, so you can change the way you feel. People say, "I can't help the way I feel." or "This is just who I am." But you were an almost-blank slate when born, and most of what you think was just taught into you by someone, so you can un-do it, and replace it with any beliefs or even emotions that support your goal. He gives a great example of funerals in New Orleans: how they play sad music for a few minutes, then break into celebration. We think that death is universally sad, right? But this shows there's another way to think about it. So you can choose to feel happy about each person that rejects you ("one step closer!"), or choose to feel disgusted by the thought of procrastinating ("it's my mortal enemy!"), or whatever you choose to feel.

Actually there were probably 100 other things like this that changed the way I think, but just seem commonplace to me now because I've been thinking them so long.

Grab any of those classic self-help books like "Think and Grow Rich" or "Maximum Achievement" or "Awaken the Giant Within". When read at the right time in your life, it can really change everything.

(( Oh, just noticed you asked about harmony. All the stuff he taught be was very basic jazz harmony that almost any book on the subject will teach. The key was how fast he taught it. ))
This ignores company culture, and the fact that people that reflect the company culture the most are the highest rewarded, and that often this culture is perpetuated by a small minority of individuals that control the companies.

I bet Cash4Gold has a ton of friendly ethical people working the lower ranks, but that doesn't balance out the fact that the entire organization is a scam.
That is one of things we'd like to highlight too, that the review process certainly is FIFO :)
Unfortunately, evolution is evolution, and if there is any way that
cancer cells can trick the immune system that does not require CD47,
trust me we'll know about it after the first few months using this drug.

I totally agree. Also, I'm skeptical about side effects. We'll see. As I said, I don't believe this will come out as an actual drug.

What I find mildly disappointing is that cancer is an evolutionary
process, but it is still treated primarily as a cell signaling disease.

Absolutely. We spend a lot of time figuring out the biochemical intricacies of very specialized tumor cells with, predictably, not a lot to show for it. My guess is we'll be making inroads this way as far as pre-cancerous and early stage disease is concerned but we simply lack the technology to deal with the phenomenon itself. To speculate further, I don't think this will be solved by micro-advancements in pharmaceuticals (even quite well-targeted ones), I believe we need a new class of active agent that can go in there and make decisions on a cell-by-cell basis if necessary.
It is easier to build a parking garage next to an intersection than an intersection next to a parking garage.
NPC soldiers with HTML5 orange shield are just too cute :)

And this is actually a nice little game. Buy then again, where is browserid and open badges support ?
Note that your numbers apply to the observable universe. The universe as a whole is likely to be infinite. Not that there is much practical difference between "the universe" and "the observable universe".
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This is not a patent.

This is a patent application.

It has not been granted. It hasn't even been reviewed by an Examiner yet. All that's happened thus far is that the application has been submitted to the Patent Office and published. That's it.
The coulomb barrier (electromagnetic force derived) for hydrogen nuclei is not overcome until a temperature of about 120 million kelvin. Obviously, no metallic materials can operate at this temperature.

Controlled magnetic fields are required to contain a plasma above the coulomb limit.
This has been a long time coming. I am happy to see the implementations of HTML5 technologies that are capable of delivering this kind of experience.
I mean 'weak' in the sense that they often fall apart, causing lots of waste and shuffling of chairs.
One idea that was actually investigated was to explode atomic bombs underground and use the heat released to produce steam that could be user to generate power. The Project Gnome test used a relatively small bomb (3.1kt) which created a 20m wide cavity - which people eventually entered (!):

http://en.wikipedia.org/wiki/Project_Gnome

http://www.wipp.energy.gov/science/ug_lab/gnome/gnome.htm
I think that combustion engines are mainly good for their scalability in terms of output: You can make a combustion engine go from cold to pulling a tractor trailer up a mountain in seconds. For sustained loads (electricity generation), the steam pressure and turbines setup is much more efficient.
I disagree. This kind of thing is a real annoyance/problem for a lot of people. Same goes for powerpoint slides.

It doesn't matter where you put blame, or if there's any blame at all; it's still a problem.
Are we still hung up on .docx? Older versions of Word have compatibility to convert them, and LibreOffice and Google Docs can open them. Instead of trying to get them to always remember to save in another format, why not tell them how to change the default saving format?

Changing every time is a pain, since Word has a dozen different options (Word 95, Word 98, Word 2000/2003, .docx, rtf, txt, etc). It gets confusing.
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Could not move while on Chrome... was nifty though, I applaud the effort put into this. One day Flash, one day...
Are there actually any materials which could withstand repeated contained hydrogen bomb explosions in the same manner as a piston? No point having a 1000x sized piston you only use 2 or 3 times.
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I have browserID supported on a few projects I've shipped, adoption comes down to the developers, all Mozilla can do is provide the tools.
I don't know. I've taught computer science in high school in the late 2000s and there still were students who dabbled in code even though they had access to the most wonderful GUIs and games. When I was young and the first computer entered our house it didn't have a nice GUI. It was dos and basic all the way down. From my siblings I am the only one who did develop any kind of interest in coding. The others were given the same opportunities as I (maybe even more so) but it didn't take.

There is a curiosity about how to get computers to do what you want that is independent of graphical capabilities and attractive games, social networks, and what not. And that curiosity somehow isn't given to all. Similarly not all are into woodworking, gardening, knitting, and so on.

(By the way, your impoverished-point seem to work for knitting/sewing as well. Why bother if you can get all the clothes and accessories from the shop downtown or the internet for almost nothing? Still there are people enthusiastic about knitting/sewing.)
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Nuclear fusion needs high temperature (so that the hydrogen nuclei have enough energy to get close together). "High" means ~10 million kelvin, several orders of magnitude higher than the fusion/evaporation point of any material.

So your giant piston will melt and evaporate long long long before you get fusion.
Because the fusion route is cheaper and more abundant not to mention more powerful. It's not an either or.
What does a train ride have to do with design?
Correction:
This is a patent APPLICATION. It is not a patent. It hasn't been granted (let alone on the first try).

The Examiner hasn't even looked at the application yet.
My first Internet of Things project, it was surprisingly easy to make with an Arduino (first Arduino project too).
I'm on Chrome and it worked fine. Took a while to connect to the server, but other than that, it works great.
> I propose an exponentially decaying tax on trades - the longer you hold a purchase, the less you pay when you sell it. If you WANT to trade at sub-microsecond levels, you can bloody well pay for the clean-up fund when your system goes bad.

It seems like any tax on trades at all (even a fixed tiny percentage per trade) would go a long way toward reducing HFT.
Of course the situation is complex.

http://storify.com/charlesarthur/oh-hai-sexism

But the tech community just effuses sexism.
It does sound like a very promising avenue, but I imagine that this route could still be a problem for people already pre-disposed to autoimmune diseases. Still, most of those aren't as bad as the alternative here. Any drug based on this doesn't have to not have side effects, it just has to be better than normal chemotherapy.
I'm talking a really giant piston and cylinder so that the piston and cylinder walls are far enough away from the blast that they don't experience destructive levels of heat. (You'd explode the bomb in the middle of the cylinder (during freefall))
Felt like I was entering a web-based rectum
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I agree that the best approach is to use a tool and deliver well built software. For every pragmatic tool you recommend some highly paid consultant or senior dev has tried to pad their resume by getting them to buy $100k of unneeded infrastructure and tools that failed miserably.

Also, some companies will not budge no matter how you present it you are better off working around the heavy process that is slowing you down. Or switch companies. Or voice you frustrations into the void of the internet like I did. http://objectatrest.wordpress.com/2012/03/27/one-process-two...

Each company is different and there is no silver bullet. You need to find out what the managers value (money, productivity, looking good to their superiors) and build a case on that.
Well said.

I guess my first thought with the Raspberry Pi was as a ridiculously cheap/efficient HTPC, and secondly as a tool for relatively poor kids to be able to have their own computer to program/explore on with decent hardware. This fills those same niches, while having some notable advantages: better CPU, GPU, compatibility, extensibility, etc. (And obvious disadvantages.)

Outside of these two niches, the advantages of the Raspberry Pi matter a lot more.
I'm comfortable with that assumption.
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See my other comment above. Let me know what you think.
I like working with other developers. Other developers seem to like working with me. I very definitely have an ego :-)

I've worked with some folk who don't seem to work well with the rest of the team. They certainly make things unpleasant for management - but that's only a secondary side effect of them making the whole teams life unpleasant. Which in turn makes the product worse.

Sometimes (not always - or even often) the person who doesn't work well with others is technically excellent. I mean stupidly good. I used to think that more than made up for the trouble they caused.

These days... not so much.

To pick one from the list - do you seriously think "Treat people who know less than you with respect, deference, and patience" is a bad goal to have? That doing that will make you a worse developer?
I could move on Chrome by clicking where I wanted to walk
If you try to add a diagram to HTML, suddenly you need two files.

That's not strictly true. You can embed inline object data in object tags (http://www.w3.org/TR/html40/struct/objects.html#h-13.3) using the data: URI scheme (http://www.faqs.org/rfcs/rfc2397.html). Whether that is good enough, I don't know. The data needing to be physically inserted at each point of use certainly isn't great for space usage and performance.

But then, in the context of email, why not just use MIME?
No. Even "crazy" entrepreneurs need to have some familiarity with their business ...
Article about how the game works: https://hacks.mozilla.org/2012/03/browserquest/
In all honesty, from Zynga's point of view, in this specific case, it wasn't worth the headache of dealing with a non-standard contract.

Sometimes, acquisitions are for talent reasons, sometimes it is for product reasons. In the former, you buy a company specifically to acquire a person (or people). Those people are aware of this & have some negotiating power. Similarly, in the latter, the acquiring company might want to keep the product team in tact (at least for a short while), so they might have some power, but in both cases, the other people are more or less on their own with a "take it or leave it" type of offer with very minimal room for negotiation. There will be examples counter to this, but this is in my experience (mostly from the "big company" POV).
> I bet Cash4Gold has a ton of friendly ethical people working the lower ranks

What you did there is the anti-thesis to my point though: if your job requires you to make specific decisions that you feel are hurting others, you are not absolved of that malevolence just because of "corporate culture". You are still an individual making decisions that you believe will hurt other people. (And that you'd be rewarded for such is even less morally relevant.) Naturally there tends to be more of that decision making power resting with the executives.

Culture is useful if we want to understand the context and root of ethical or unethical acts, but it doesn't whitewash them – most people don't believe that growing up in a tough neighborhood makes it ok to steal, even if it does give that act context.
See my other comment here about the drive to "be the next Zuckerberg".

Then look into the conditions of "flow" : http://en.wikipedia.org/wiki/Flow_%28psychology%29

1. A clear set of goals : you know exactly what needs to be done next.

2. The task is not too easy, but not too hard. It's just at the edge of your ability.

3. The task gives you immediate feedback.

When you're engaged in that kind of work, you FOCUS! That's why video games are so addictive! They play up these 3 conditions so well. You have no problem focusing when playing a video game!

Also it's pretty crucial to have all this work be leading to a goal that you want so badly - whether it's to be a millionaire, to be famous, to be in Y Combinator, whatever.

Then it's also crucial to have this goal be so close that you know if you just keep working well that it's very likely you'll get there.

Get those situations lined up, and you'll have no problem focusing!

(( And yes, I'm embarrassed to admit I have a major problem with focus in my life right now. Apparently it's kind of common for recent mutli-millionaires who have surpassed all their previous goals. What's next? How can I top this? Do I want to? Do I just retire now? I have some new goals, but they're not burning goals. And I just realized they aren't matching steps #1, 2, 3, above. Hmmm.... ))
Considering I am working in a construction company I couldn't disagree more.
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Webcomics and animations: How to stand out from the crowd?
I'm starting a comic site at doodleskull.com. It will not be your typical frame-frame-punchline comics, more like infographic-style drawings and doodles about problems, irony and other adventures I run into in my life. Let's say really colourful personal stories. That's one way of putting it.

But I don't want to make a comic site that 520372947 people have already made. You know that kind comic site you've already seen a dozen of times. I want to bring things up a notch and make something that people actually want to read and see. To do something different. That's why I wanted to turn to you and ask for ideas.

My "how-to-make-awesome-comic-site-like-no-other" ideas so far:

- Make animations. People are vlogging with a video camera, but no one is doing that with animations. Again, I would not do Pixar-quality animations, more like rage comics meets South Park meets Powerpoint. Very DIY, amateurish you could say but highly personal.

- Make comics with HTML animations, with tools like Hype or something else and keep the infographic style. SEO-wise this would be a suicide, because javascript doesn't offer much flexibility with SEO, but: it's the content that matters, not search engine optimization.

- Provide a new comic and a new video every single day. Most webcomics do new stuff a couple of times per week. By putting drawings out everyday, I would stand out from the majority and that schedule would keep me drawings and creating every single day. This would be very time-consuming, but I don't mind that.

- Mix and match infographic layout-style with the personal comics and doodles. I really like infographics, but I don't want collect data and publish one about how many people are jackasses on the workplace on average. I'll rather be inspired by infographics and use that inspiration to put out, hopefully something unique.

Any thoughts? I'd be really thankful for any ideas or thoughts. Any thoughts. Seriously guys, I'm desperate.

Seriously.
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I'm almost jealous that you had a teacher as great as you did! We need more Kinos!!!
These statements are kind of like zen koans - open to different interpretation and depth of understanding. I don't see anything on that list that would preclude someone from doing something great, and a great many things that would probably help.
Google docs works infinitely better for this. The feature set may not be as comprehensive, but it nails ~97% for me, and the ease of collaboration is far superior.
A working piston of this sort would generate extraordinary sums of energy in a relatively short period of time, you'd need a storage device so the energy could be distributed when needed.

Any breakthrough in output will need equal or greater breakthroughs in transmission and storage. Makes the whole equation that much harder: it's not enough to just crack one of them.
It's also close to impossible if the journal or conference doesn't give you a LaTeX stylesheet, which is uncommon outside physics/math/CS. Sure, you can in principle produce your own stylesheet conforming to the formatting requirements, but even most seasoned LaTeX users find the stylesheet language to be black magic (I dread having to make even minor edits to a stylesheet).

Matching citation styles used to be a problem also, but tools like Jurabib and Biber have mostly solved that problem.
If it is going to actuate more than once, then the heat will have time to equilibrate sufficiently to destroy your piston.
I'm in my 4th year at Warwick doing a Maths degree. I could have done a PhD for £14000 a year, or get a job in Financial Software Development at £40000. Furthermore, I'm more employable after the 4 years of work than the PhD.

I didn't even have to learn any Stochastic Analysis!
View > Document view > Compact

Yeah, Google made a mistake in changing the default to Paginated. Still, Docs is light years ahead of Word + trying to emulate git's CVS via file names and mental notes.
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