skysight-inc/HackerNews huggingface dataset:
I have CF and I was fortunate enough to qualify for Trikafta despite one of my protein mutations not responding to the drug. I have seen some great quality of life improvements from Trikafta like being able to go to the gym again, not being as winded climbing stairs, gaining weight, and having fewer lung infections.

However, Trikafta can't reverse the years of damage from CF, inflammation, and heavy antibiotics to combat nasty infections. I do experience some anxiety and mood swings and have developed recurring kidney stones since starting it.

Still, I am thankful that such a drug is available to me and many others like me. Maybe one day CFers will never understand what it means to have advanced lung disease.
Microphone on the chip or via an attached peripheral?
It's common for people to choose to try to not have a child with a serious genetic disorder.
The collab everyone has been waiting for: Princess Cruises + Chipotle - Norovirus on the High Seas
Is it true, is it kind, is it necessary. My dad taught me that. I break the rules all the time but I try make it 2/3. How are you today.
Hasan Minhaj’s “Emotional Truths”
Nope, GA plates registered in Fulton County (aka the same county that ATL is in). GA driver's license too, and the car was registered under my name.
Sathya since taking over pivoted Microsoft’s strategy in a fundamental way that no other CEO did. I mean Tim Cook did to some extent firing Ive and all, but they still sell iPhones to people.

Microsoft embraced open source and the cloud when its original profits from the opposite of those two.
From what I heard, Unity China is not actually owned by Unity, and Hoyoverse has a stake in Unity China: https://www.gamesindustry.biz/unity-reportedly-looking-to-se...

So the answer here may legitimately be that Hoyoverse isn't affected by this.
I used to always use .forEach but now I use “of” as much as possible.
Fully compiled languages have another huge advantage.
If you write a tool in Python and targeted say Python 3.10 then people using Phython 3.9 might not be able to use it. So, you really can't use latest and greatest features of Python 3.11 or 3.12.
However, with Go, you can build your tool in Go 1.21 or whatever, and the user does not even need a Go toolchain on their machine.

I was planning to write a small side-project to generate GitHub Actions boilerplate. And this time, I intentionally chose Go for that exact reason.
https://github.com/ashishb/gabo
> Even here—imagine what more you could justify by looking at the “penumbras” and “emanations” of that clause of Article II!

You could justify a theory of an immense array of independent Presidential powers hidden within the penumbras and emanations of the phrase “Commander-in-Chief”, despite that phrase being simply a limitation on who has the apex command position over the military under the regulation Congress is clearly and explicitly given the power to provide for it. Just to pick one example of where the Right has demonstrated the exact creativity you deny that they exercise.
Why does the fertility rate even matter? The world seems to have far more people than it can reliably sustain.

If we reach 1/10th the size of the current population, then we can start to wonder about fertility rate if it drops further.
Not sure, but it was this[0] parking lot. It was behind a place that is currently marked as Sebastian Pintxos Bar on google maps. At the time, it was a korean-mexican fusion restaurant, forgot the name, it closed down permanently not that long ago.

0. https://maps.app.goo.gl/dQUE4yaaJTqVQ7En6?g_st=ic
Looks like Church’s was acquired by Prada USA corp in 1999. They may or may not be the same quality now.
At 3 dozen I wouldn't find these either. Absolutely agreed. 6 or 8 cassettes in the (waaay back) cassette thingie. So I'd know what was where. Same amount of music but less CDs when it was just regular CDs. And then just one or two MP3 CDs.

Most cars I have been in have abysmal automatic climate controls. Either too hot or too cold. Manual adjustment needed. For that I need knobs. If you give me a car that can actually keep me comfy without needing to adjust things I don't mind not having knobs. Yet to find such a car. Thus I need knobs for that.

For the music definitely need knobs. No car is gonna figure out my mood anytime soon. Thus I need knobs to switch to folder 3 that has my "calm me down music" or folder 5 for "I need Euro Dance now" etc.
And what is the DNA profile?
> Even here—imagine what more you could justify by looking at the “penumbras” and “emanations” of that clause of Article II!

To look at a different clause of Article II, you could justify a theory of an immense array of independent Presidential powers hidden within the penumbras and emanations of the phrase “Commander-in-Chief”, despite that phrase being simply a limitation on who has the apex command position over the military under the regulation Congress is clearly and explicitly given the power to provide for it. Just to pick one example of where the Right has demonstrated the exact creativity you deny that they exercise.
Nice idea, but that site seems to track only "food" that is basically poisonous to begin with.

If these brands make the portions smaller, they are actually doing us a favour.

After a quick browse, I haven't found anything on that site that actually qualifies as food.

Couldn't care less how prices of these items develop.
tell you when the (relatively speaking) peanut gallery joins in?

You may not have heard of them but each of these companies have a billion downloads in their portfolio minimum. This is massive that they all rejected this.
I'm glad that I recognized that we (Gen Z) were growing up with this narrative pretty early on--if you get a job, you have to be best in the field. If you start something, it has to be big. Small successes or positive changes just weren't adequate. I wrote about this in more detail here: https://www.tor.com/2021/05/25/anyone-can-be-a-hero-in-brand... and I said it better in this paragraph than I can right now:

"Because the real world has never been saved by a few superheroes. It has always saved itself on its own, each person doing their own little bit. In the real world, although many people feel—and sometimes are—helpless because they’re not the “right” gender or race or caste or class, there are many, many more people who have made their own little impacts on the lives of others, be it buying groceries for elderly neighbors during the lockdown, running a lemonade stand to raise funds for cancer treatment, offering free therapy, teaching kids in slums, or distributing food to protesters. Our world is humanity’s collective effort, one big project that we always keep working on.

The problems all of us are fighting are too big to change individually—they are too massive in scope, with too many variables. But collectively we have changed some things for the better, and we’ve done it by being whoever we are and doing what we can, while also learning and taking tiny steps forward..."
Im convinced Go is just an incomplete language masquerading as a simple one.
>but publishers started complaining I guess (who knows why? maybe they wanted to one day launch their own services, heh, good luck with that).

They could simply want Nvidia to purchase rights to use their game. If you made a movie you wouldn't want random streaming services to be able to stream your movie without paying you for the rights to do so.
The incentive already exists and that is to become a modern society.

The poor countries will reach the same when they develop.
I graduated from an Indian university. This situation was better, but not significantly. The syllabus is mostly adapted from US universities and generally prescribes the same textbooks. These US books are exorbitantly costly in Indian currency (due to difference in purchase power parity), so many books have cheaper prints exclusive to the Indian subcontinent. They are still costly and there are books that don't have a cheap edition. It's often outside the budget of students. Libraries help - but there aren't enough copies for all students. This problem is somewhat mitigated by the fact that there are books by local authors designed around the syllabus with the semester exams in focus. Those books are more similar to lecture notes. My experience though, is that those books are mostly good only for rote learning. You need to refer the prescribed textbooks to get any reasonable insight. And then there are books not in syllabus that offer much deeper insight. So - the situation is better than in US, but not significantly.

On a tangent, the tendency of Indian universities adopting syllabus from its US counterparts leads to use of proprietary software like Matlab. Software companies in US supply student version of their software and often tie up with the university to get it into the syllabus. But its much harder for Indian students to access the same software. Some universities have identified this problem and have recently started prescribing open source software like Julia and KiCad.
trains reaching 125 miles an hour

Definitely not "the future of passenger rail*.

In today's world those speeds are decades behind in the past.
I know someone with relatively bad eczema and I believe you when you say you believed you had nothing to live for. I’m genuinely glad you were relieved of that. It seems like it can be terrible to live with.
What were the backward incompatibilities preventing that move? I thought Java was pretty backward compatible, but I've heard this a lot.
Kurt Vonnegut's theory of story shapes
it's been in argument for years. I don't think the US will ever step in given its culture.

Also, I'm unsure how you step in and "regulate social media" to begin with. The whole issue is that social media provides much of its content via users, and users take these bathroom writings as gospel. That's a societal issue. Even if you regulate the money out of social media people will just join some home spun sites or even the fediverse, and the core problem continues.
While you might edit a long song down to a radio-friendly length, I think most songs start out short enough to be radio-friendly in the first place. 3 minutes is about the natural for a typical verse-chorus-bridge structure song. Cut out the bridge and the song will probably clock in closer to 2 minutes.

These longer songs, like Foreplay / Long Time, have a lot more going on. More ideas. More sections. Dramatic crescendos. Extended instrumental parts. They're harder to write.

The standard verse-chorus-bridge structures are popular because it's a really damn good way to write a song.
I believe that's a Buddhist expression about "right speech".
> not so great if you want to distribute software for people who are not software savvy, who typically just wants to download one file, install and start using it.

i think it's a flaw that wasn't considered properly in the standard java toolchain to not produce an embedded java runtime into a final packaged artifact that is self-executable.

You end up with third party tooling like: https://www.ej-technologies.com/resources/install4j/help/doc... (and https://launch4j.sourceforge.net/ too).

If oracle bundled this tool into the JDK, it would've not been an issue at all.
MitM is not "intercept and decrypt arbitrary traffic on the network" which is what was asserted. You are describing an active attack, while fiddlerwoaroof was discussing a passive one.
I’ve written go code for large corporates in Australia who absolutely did not have a tech or software focus. One was a notoriously bureaucratic company which used to be a government owned enterprise. For the niches it fills well, it’s become almost ubiquitous.

With regard to this:

> But most enterprises that have a non-software focus generally prefer languages that have been around for a while and are known by lots of people.

I know developers who work for large blue chip financial sector and other traditional sectors. They’re on the same React/Vue/Webpack/whatever treadmill as all the frontend devs devs working at web dev agencies. And they’re often compiling it down from TypeScript, which has not been around for a very long while at all and is not known by lots of people (relative to the size of the JS community.

Swinging a bit of Go for a service in an environment like that isn’t really that hard.
There was a time when it (or underscore.js, its predecessor) was a useful collection of Array methods, but since then almost everything of value in underscore has been added to the Array prototype itself, so I don’t really see a point in using it anymore. The devs know this too, so now they’re just bored and rewriting for no particular reason.
"Prefer composition over inheritance" is actually a well-known mantra and appears in, for example, the Design Patterns book from 1994, which is basically the OOP bible. And this is within the OOP bubble, you won't even find inheritance outside of it.

https://en.wikipedia.org/wiki/Design_Patterns

Don't take undergraduate OOP courses seriously.
The steam deck could do that a year before the Ally and with much longer battery life
Dupixent rocks! If you ever get sick of infections, it sounds like JAK inhibitors have opened the door to daily-pill eczema treatments too.
There's nothing wrong with feeling this way, but you're comparing a very small company (your own) to a much larger corporation.

The appeal of AWS' "insane" bills are that they are not so "insane" when compared to the salaries required to maintain a home grown stack in-house, especially as complexity increases.

It's not just application complexity, it's organizational complexity. Doing everything yourself is fine until that complexity increases and you start finding out that all your dozens or hundreds of expensive employees are spending a lot of time on home grown overhead.

For example, when you use shell scripts for your deploys, you can't as easily prove things to auditors like you can with a CI/CD system that's tied in to role based access control. That sort of thing will be dealbreaker for customers who expect your company to maintain industry compliance standards.

When you use a product like RDS you can tell your customers that Amazon is the one responsible for handling backups, security patching, etc.

Also keep in mind that anyone with a significant amount of AWS infrastructure should be buying reservations and savings plans. The sticker price of AWS is not what corporations pay.

As you grow your company, I encourage you to focus on the activities that make your business profitable and deliver value to customers. Every hour you spend upgrading a database or patching an operating system is an hour you could have been spending on developing a unique feature in your product that nobody else has.

For now, I'm sure using this setup is much better than getting something too complex for your size, but that can change quickly if you're lucky enough to reach a larger scale.
> C# keeps being the language people are looking for but don't know about.

Every time I point out about C# most programmers are saying about evil Microsoft and being locked in the ecosystem. Most programmers I've met do not even know that .NET Core is MIT open-source and runs on any device.

I really wish C# would be more widely used because it is amazing, and for sure 10 times better then Java.
Canadian vocabulary is pretty much the same as American, we say “gas”, not “petrol”, and use “I guess” instead of “I suppose”, but there are still some spelling holdouts, like “centre”, “theatre”, “colour” etc. But spelling of the “tire”, for example, is American, not British.
Not that “ufologist” here is a somewhat unusual shorthand for “serial fraudster who has previously tried to pass off bodies of deformed human children as aliens”.
It's more likely that there's some dependency that is not easy to upgrade, because the upgrade also includes api changes (from the dependency, not from the jdk).

Compound this with multiple dependencies that exhibit this issue. If you have a "legacy" application that does not require active development, there's zero business incentive to invest into the upgrade. Unless you could prove value in having the upgrade, it just doesn't get prioritized.
I don't have CF, but I am inspired by the pace of scientific advancement when I hear stories like this one. Thank you for sharing, and I hope every one of your years brings further boosts to your health.
Yes, and I object even more to people who have "Thanks," as boilerplate email template, as I've seen multiple people do. It means more if you type it.

But those are nothing compared to people using LLMs to generate ostensibly handwritten emails.

kthxbye
California woman loses limbs after battling bacterial infection from tilapia
Its a good language, but the corporate sponsor and community is suspect. Microsoft has a long history of user hostile actions. The types of companies that use C# often treat SWE as second class. Learning and using C# limits career options to low salary, high stress jobs.
> I’ve learned so much from not reading :)

Same here! Since realising that, I've not been so worried about reading everything I've saved, or even thinking that I have to read everything I come across just because "you learn something new every day." I graduated a year ago and have done lots of work and reading since. How different would my life have been if I'd applied even 10% of what I learn?

I still love learning stuff, but now--unless it's required for work--don't go looking for things to learn. I am doing much more as a result and I'm happier than I was when I simply spent my days learning.
No git repo?
>would fall on deaf ears in Congress

Looks like you missed the part where the US Congress has no control over how the 50 states select electors.
better_than_having_just_a_single_file_that_have_lots_of_functions_without_namespacing
Wow, to think that recurring kidney stones are better than what you were experiencing before. That’s incredible. Regardless, I’m glad you’re doing better.
> delivering actual software while you figure out how React 32 broke your transcompiler.

Say that to enterprise software systems still running on Java 7 or 8 without any clear path to upgrade because their whole systems will break.
And often even afterwards.
Sure, this drug ends up being profitable.

But most of them also cost $150M to develop while making $0.

As a whole, I don't think the pharmacy industry is unusually profitable.
Much of this is about the dirty part of the supply chain. Take solar panels, china makes like ~90% of the worlds supply, yes there is the high end research, but then there is the poly silicon mining and refining/ingots, wafer, cells, and modules. You can’t just reshore some it - you have to do all of it, otherwise it doesn’t make a ton of sense, and that means mines and refineries which we’ve rightly or wrongly stopped building here in the US.
Since Java 9, developers can use jlink to provide a pre-packaged runtime environment bundled with the application. It's not static-link friendly or a single executable, but it does not require the user to pre-install anything or pull dependencies at runtime.
White noise and other background sounds cause issues here.
I'm going to echo what the other poster just said.

If I know something is a solvable problem, I don't worry about it, it's just a detail. For example, if I have to integrate with a 3rd party API, the details don't matter until I get there. I have full confidence I'll be able to do that even if it's a super old school strings over tcp before XML was a thing. Because I'm fully confident in being able to solve that, I don't care about it, it's just a detail, like having to reverse your vehicle out of your driveway.

It may even be that he's not completely sure of the details yet but he's confident he knows the approach to take and he'll do the discovery while he's working the problem.
I was able to find a project which appears to do exactly this: <https://github.com/atbarker/AONT-RS>

Paper: <https://www.usenix.org/legacy/event/fast11/tech/full_papers/...>
You mentioned "distribute software" but did not consider Electron for Node.

You can make an Electron app with JavaScript and ship the binary (or installer) on any platform. It's not a single executable file, but the user experience is the same.

I don't think there's an equivalent in Go that allows you build a desktop app like that (with frontend and backend both written in Go)?
I do sometimes wonder if I'd be better off being a bit more afraid to be wrong.

I always want to know more stuff and I will always fess up to my ignorance in pursuit of that.

I do suspect it makes me sound like I know less than I actually do, considering a lot of peoples reluctance to ask.
How much of that $30b is true cost (R&D/manufacturing/distribution) versus cost + profit? Cuz I'm guessing a lot of it is profit.

The actual sum of money required to keep those 100k people alive is likely much much much smaller.
Of course not. Most of it is just binary blobs. They just open source how to interface with the blobs
> functional programming is about functions

different people mean different things when referring to functional programming.

Some people believe that functional programming are using higher-order functions like `map`, `reduce`, `forEach`, etc, which takes a function as a parameter, instead of doing imperative loops.

Some people, in addition to above, believe that functional programming is about creating functions that take a certain 'shaped' parameters, to allow for automatic checking.

And lastly, the "real" functional programmers are people who believe in referential transparency in your functional program.
They both seem primitive. If a user paid $10/month for a subscription, each month they should divvy that $10 to the proportional minutes listened of each artist for that month. That’s paying out to the people that are keeping that person subscribed. Minus Spotify’s cut of course
> I am always torn between reading and not reading. I think reading energizes me regardless of whether I can effect change on the topic.

If it energises you/brings you joy, then why question it?

> Simply having awareness can be beneficial on some level.

It is, but what I realised at one point that there are just too many things to fix and you can spend your entire life becoming aware about them. I think it's better to choose a few or even one problem and go deep or actually do something. But, as I wrote in the post, that's something that works well for me. YMVV.

Edit: John Green explains this well in this video: https://www.youtube.com/watch?v=Bew3EMicf8g
> The point is that if you used a 1kb random password for service to service auth and someone tried to sell you a $400/mo service to generate them, you’d laugh in their face and then have security escort them from the building.

Go ahead, run an internal secret store that issues properly trustworthy internal certificates. It isn’t hard, but neither is it cheap not. You oversimplify and gloss over a few _really_ important aspects of why and how certificates work. A certificate _acting like a password_ in some cases doesn’t mean it actually _is_ a password, and if you don’t really need the additional functionality to the point where the cost outweighs the delivered value, you are using the wrong tool for the job.

Running a CA is not at a technical challenge. Running a _trustworthy_ (there is that word again) CA is process heavy and it involves quite a few people doing work on a regular basis, and without those processes you may as well just something else - like an untrusted CA, or some kind of token issuing service (which, shockingly, also costs money to run properly).

A few really good options around DIY CAs were mentioned in this discussion, smallstep is pretty good for example. Nothing (except possibly your $org’s security policies) prevents you from throwing that up somewhere and start vending certs.

The fact that it is an internal CA to be used for internal purposes makes no difference, unless you believe that “everything internal is trusted because it is internal” in which case many other discussions on a very wide variety of subjects is due.