> when I was looking at this ~6 months ago, it seemed that most of the options were surface mount

That's because most components today are only available as SMD. Once you play around with higher speed digital chips, breadboards are not really suitable anyway. But don't worry about SMD devices, there are manufacturers like e.g. JLCPCB which build the PCB and assemble it for you if you give them the manufacturing files. In that case you give them your Gerber + placement files and you get a board with all the SMD parts assembled already and you only have to solder e.g. connectors yourself. The board will be indistinguishable from something you'd buy in a commercial device. It's also cheap enough that it's totally fine to do this for prototypes, but it will usually take a while (think of 1-2 weeks) to get the board, so "prototyping" is a bit slow.

If you have no idea about this / never did this before, maybe start with a simple test board where you figure out how to use e.g. KiCAD to design a PCB and how to get it assembled? It's quite easy, but you should be familiar with the process before you attempt to build anything more complex, simply because everything you build costs money in the end and if it doesn't work, it's annoying.

> I didn't think about the RS232 for debugging, but that's a good idea.

In case you wonder why I said RS232, it's probably the simplest protocol (electrical and logical) you can use, which makes it really hard to mess it up. In most cases all you need is an RS232 transceiver chip like an SP3232E and a UART interface on your FPGA/MCU/...

> speakers are not powered

Means: you'll need some amplifiers too. You again have two options: get some cheap commercially available amplifiers and only think about the mixer or completely build it yourself. If you build it yourself, you could look at Class D amplifiers, there are chips which directly translate digital I2S or TDM signals to the PWM signals for the speakers.

> I have a PhD in CS, but I've never worked with FPGAs!

In that case it will be quite the learning curve, because with FPGAs you don't write "software", you essentially describe a digital chip instead. A good starting point would probably be to get one of the cheap FPGA evaluation boards, ideally with an FPGA similar to what you want to use in the end. Keep in mind that if you put an FPGA onto your own board, you'll need some way to program it, like e.g. a JTAG programmer. That's the same with microcontrollers too btw, except you might need an SWD programmer then if it's some Cortex-M MCU. And if you get the one supported by the chip manufacturer (or a cheap Chinese clone of that one), things usually get easier because then it's supported by the development environment of the manufacturer.

> I'll look into the MOTU devices... I had not heard of them before!

You probably didn't hear about that before because it's "pro" audio hardware and not something an average consumer would ever buy/use. In this case it's only line level, so you still need amplifiers for the speakers afterwards. Maybe you'll find something that's even better for your specific use case. For commercially available amplifiers, you could again look at "pro" hardware which usually comes in 19" rackmount cases and sometimes there are even other options for "fixed" installations. That being said, be careful to not get an amplifier which is way too "powerful" for your speakers and you can also waste a lot of money on fancy things you don't need.