skysight-inc/HackerNews huggingface dataset:
Better potential mechanism:

* person gets infected

* enyzmes needed to fight infection are used more

* these enzymes need cofactors like manganese, zinc and iron

* Patient becomes depleted in Manganese, zinc and iron.

* since these cofactors are needed to control oxidative stress in the mitochondria there is more oxidative stress in the mitochondria

* fatigue

https://onlinelibrary.wiley.com/doi/10.1016/j.cdtm.2020.11.0...
It’s really easy to be in a state of denial to anybody. Health issues especially. It’s not a character flaw, just common human nature. It’s really damn hard to perceive your own positin objectively.
It's an end run around re-imbursement rates for insurance and how the pharmacy benefit managers get paid. Basically an artifact of why capitalism sucks.
Gamblers hardly intersects people who spend their money responsibly.
It's irrelevant how good your work actually is, only how well it is perceived. Take pride in your work, but understand that others are not responsible for making your contributions known. I feel this rule applies in relationships as well.
> "Start suing start and start lobbying."

This could actually have an effect (at least in the USA) now that those kids in Montana set a precedent with a favorable ruling in their case if enough people take the cue and file credible (non-frivolous) cases. It's certainly a preferable option over the whole "eco-terrorism" path which in the end will likely just escalate to literal all-out civil war.
Sadly, not that simple, few major issues here, we are exporting extremely low value, high water, crops overseas, like alfalfa. We are also growing these low value, high water crops to feed to animals (which also consume a lot of water). We don't need to subsidize these activities, particularly not the former.
Not at all. Post a form submission, send back either the same form with errors displayed, or simply return out-of-band updates to error message divs. You can redirect from the response as well using htmx, so if the form submission is successful, you can redirect to a success page ... or simply update a div with a success message.

If you get a request asking for json, you just return a json with the same thing. Not much changes with API design if you were designing the API well in the first place.
Yes, that's the problem with US political-economics right now. You've (failed to?) identify the "political" part of "political-economics".
Same boat.

I’d love to host something local but have been so overwhelmed by the rapid progress and every time I start looking I find a guide that inevitably has a “then plug in your OpenAI api key…” step which is a hard NOPE for me.

I have a few decent gpus but I’ve got no idea where to start…
It's what every single Twitter/Musk related post ends up being on HN: "Elon Musk bad", then pointless arguing and moral grandstanding.
I think that just throwing chemicals out and assuming they’re okay unless (and until) we can prove otherwise is obviously negligent and no intelligent person would believe there wouldn’t be a price to pay in human lives for at least some of them.
I find nothing saying they didn't implement manifest V3. The only info I can find from them is that their own adblocker, which isn't an extension, will continue to work[0] and that, for example, ublock will continue to work as long as google doesn't remove manifest v2 support.[0] Seems odd to me that what Google does to manifest V2 matters at all to Brave, if Brave is indeed a fork and not just chromium with a skin.

0: https://twitter.com/brave/status/1574822799700541446

1: https://twitter.com/BrendanEich/status/1534893414579249152
Twitter's response to US Government search warrant (turned over deleted DMs) [pdf]
Eventually making it back into aquifers could mean that in 500 years it mostly ends up in an aquifer near somewhere 500 miles down river/wind or something similarly unhelpful to the region in the short term.
Shouldn’t the people decide what constitutes shielding and sheltering by themselves?
> Visibility and self-promotion is how you get ahead in the workplace. Staying quiet and focussing on good work because "it'll speak for itself" is naive and in general the result is only to be taken advantage of.

It really depends.

Self-promotion really helps with internal promotion. But it seems like the best way for entry-mid level employees to progress their careers is external promotion aka taking a better job with another company.

For more senior workers, the political game is probably necessary to participate in, simply because it's more and more part of the job inherently. And there are fewer openings in other companies to jump into.
Why should energy, unlike any other service or industry, require no labor to provide
You actually said the exact opposite of that
You mean like welding gloves?
The courts in this case are interpreting the constitution of the state of Montana, which was written and ratified by the legislature. Quoted below:

Constitution of Montana -- Article IX -- ENVIRONMENT AND NATURAL RESOURCES

Section 1. Protection and improvement.

(1) The state and each person shall maintain and improve a clean and healthful environment in Montana for present and future generations.

(2) The legislature shall provide for the administration and enforcement of this duty.

(3) The legislature shall provide adequate remedies for the protection of the environmental life support system from degradation and provide adequate remedies to prevent unreasonable depletion and degradation of natural resources.
The alfalfa growers and the industries they support, such as the beef industry, have successfully convinced Californians that their water issues are entirely due to growing almonds. There have been so many news stories about growing almonds in the California desert, but almost none about alfalfa.
What alternative(s) do you propose?

How do you think spammers and abusers will exploit those options?

Again: HN works in general, and the historical record strongly confirms this, especially as compared with alternative platforms, Reddit included, which seems to be suffering its own failure modes presently.
The machine wants you to work, and in return the machine gives you money, and some times other benefits. You don’t need to work. But modern life is probably better if you do. I’m personally tired of this debate. It sound like some sort of secret cabal is being blamed for how things are. It’s mostly a free market and everyone here mostly have a choice of where to allocate their time and energy.
> But often something like >90% of the water goes back into the ground, where it will eventually make its way back into the aquifers and rivers.

That's not the case in the lower Colorado basin. If it was, there would not be a problem.
Awesome news. I have been a user since intercooler.js days and then moved to htmx.
Schmidhuber lab on fire again
Or there inability to keep an already successful product successful.
He had taken refuge to the other end of one of his other bridges, and police didn't dare cross it to arrest him...
Bravo. I had a laugh from reading this which quickly turned to horror after I realized it might actually come true
Well, that means stylelint has a problem. They should be talking about how to solve it, because nobody wants to not enable debuging information on a develoepr build. If the devs do not acknowledge this as a problem, this means stylelint is a bad piece of software.

I really dislike sass the way it's normally used. It was once a necessary hack, but it's mostly not useful anymore. Something that just concatenates your CSS @include on deployment would bring more value nowadays.
Yeah, I always describe tailwind as a lightweight classname-based abstraction over native css rules. It's a _good_ abstraction because it doesn't obfuscate the actual css rules; you're still wielding css when you use it. Colocating styles with components using short hand for css rules is brilliant and now that I've tasted it, I'm averse to our tradition of hiding things behind a bunch of subjective class names in a different file. Not too mention the optimization of removing unused styles based on the classnames used. Tailwind is good
Q: It's not safe out here. It's wondrous, with treasures to satiate desires both subtle and gross. But it's not for the timid.
Math proof draws new boundaries around black hole formation
> The problem is that farmers don't get the water from the faucet, but through archaic water rights to rivers, lakes, wells, etc.

By "archaic" do you mean they got there first? Because farming has been around in (e.g.) Arizona for >100 years, and there weren't any problems back then when there was mostly a whole lot of nothin' in the region.

* https://podcasts.apple.com/us/podcast/an-arizona-farmer-on-h...

* https://podcasts.apple.com/us/podcast/understanding-the-real...

Then folks decided that building large population centres in the middle of the desert was a good idea, and here we are.

It should also be noted that Native Americans were also living and farming before white settlers arrived:

* https://en.wikipedia.org/wiki/Phoenix,_Arizona#Early_history

Though it's not like having large civilizations living in a desert is unique to the American (South-)West: see Mesopotamia and Egypt. They're just usually huddle around rivers.
Yes.

https://amp.cnn.com/cnn/2020/12/21/europe/russia-navalny-poi...

But could be warning as well, ofc. The point is, we don’t know. Whatever the outcome, it’s a show of force.
SGD is a method of learning from examples (mapping X -> y). RL is a method of search (maximizing reward signal in a potentially open-ended environment, based on feedback on the actions that a model takes). Go was solved by combining learning and search (e.g. narrowing the search space with learned, educated guesses).

Pretrained dense GPTs don't search in any conventional way. However, when these GPTs are fine-tuned using RL, an aspect of search is reintroduced. One the most interesting directions labs are pursuing to improve on today's best LLMs is to fine-tune them with search (RL) after a learning-based (next-token prediction) pre-training.
I like the carrot honey from the carrot seed producers. Pretty unique to eastern Oregon as most places have cross-pollination with varieties to grow carrots for seed and the places that grow carrots for carrots don't get flowers so they don't produce honey.
The vast.ai FAQ claims they take 25% of the hourly rate: https://vast.ai/faq#Hosting-General
...You realize that any moderately sized corporation will monitor things like changes in IP address correlate with changes in location for compliance purposes?

That the fines assessed against the employer for allowing work to take place that violates the terms of immigration based eork visas is quite stiff?

Unfortunately, your advice is downright terrible and simply will not work. Most of the western world has outsourced immigration enforcement onto their private employers. While it may not have been a big deal in earlier times, the mapping of the IP space, and geolocation capabilities based off of it are an omnipresent to the modern corp. We alread live in the dystopian surveillance hellscape.
I don't know anything more about it. My guess is that it's pretty old. The book pictured next to it says 1914, and that broad time frame feels about right.
There are a lot of frameworks/libraries/template-engines that use custom attributes and similar syntax and Angular definitely wasn't the first one.
> How did it get this way?

Users were enamored by custom drawn UIs, so designers started demanding custom drawn UIs instead of native widgets. Most users don't understand what they lost and now pawing at interfaces to discover how they work is the new norm.
that's not what it means.
> For two years, workers have embraced the concept of “quiet quitting,” as they reject hustle-culture and prioritize work-life balance.

The media trying to make some marketing firm-born alliteration a thing.
I'm interested in moving into this sector. Do you have any resources/companies/etc to share?
Sweden Is Not Staying Neutral in Russia’s Information War
Don't forget that every few years, some new styling standard comes out. Forget tables, everything is floating divs. Forget floating divs, it's flexbox now. Forget flexbox, we're using columns.
There was a Valtrex trial a few years ago, and the results weren't impressive. Valtrex didn't even reduce EBV titers more than placebo (table III):

https://iv.iiarjournals.org/content/invivo/21/5/707.full.pdf

Other trials into antivirals have been negative.
My favorite part is when the government suggests to Twitter that they should Ctl-F to find 'associated accounts'
https://archive.ph/LtIPu
> there are other strategies

True, but those usually involve adding some sort of linter to ensure that your style sheets are clean, which is an additional build step, which is an opportunity for a build to fail. Tailwind gives me this out of the box and doesn’t require any sort of manual lifting because it does this automatically.

> Tailwind starts to break down for larger/complex apps also

This hasn’t been the case for us, I’m on a team of about 50 devs contributing to a 2 year old monolith and Tailwind hasn’t once gotten in my way.
What else would a proper VPN be besides a particular way to have a internet-wide proxy (as opposed to e.g. just a web proxy)?
Interesting! Thanks for running mediainfo on them to compare.

When encoding videos there's a "speed" parameter that basically tells the encoder to spend more CPU time compressing the frames. It results in a smaller output size while maintaining the same level of quality but takes much longer to encode. I'm sure that's part of what YT is doing here, an initial quick encode to get the video live then another pass to reduce filesize for long term storage. Good find!

I'm guessing that the perceived higher quality in the smaller file is because the encoder was able to find a more accurate way to represent those frames with the same or fewer number of bits since it has more time to search for the optimal encoding.
No. It does "good" with about 25% of it's income. A lot of that "good" is stuff that the government or local councils would just fund directly if the Lottery wasn't paying for them. Much better to just give money to your favourite charity directly.
Yep ... or just putting this info (keyboard shortcuts) in the "Help" menu which is the last item in a standard menu bar.
The random bolding of words reeks of adtech.

is the usage of such an old html tag itself now a trigger to send something to /dev/null?
I am not looking forward to a future filled with this type of surveillance.
But Go started at Java 1.1 levels, for no good reason. If you want a language with a conservative growth, Java is your choice.
This is one of the reason mixed office environments (remote & in the office) can be very challenging for remote employees. It's much easier to get incidental recognition in conversations around the water cooler and walking in the halls with management. Those types of things need to be more intentional and explicit if you're a remote employee. It's way too easy for good work to just go unnoticed.

Managers it's part of your responsibility to help your workers get the recognition they deserve, but this is especially true for your remote workers due to the circumstances above. Competent remote workers who need little oversight are at the highest risk of this missed recognition and are in the best position to quietly find another job if they don't see it. You should always be looking for opportunities to highlight the accomplishments individuals on your team as well as the team itself. Publicly failures are your fault while wins are thanks to your team.
Awesome work! I love the simplicity of htmx. It’s one of those tools that makes me feel super productive.

Will there ever be a “htmx“ for building mobile apps?
The worse is the people who do know what vi is, and assume that it's a vi plugin or worse, an editor using vi bindings, and ignore it.
Fred Fish
>> Link and the objects he rides on move together at the same speed, rather than Link being technically stationary on top of a moving object as is common in the physics of other games.

>This is just how physics work. Aside from the absurdity of trying to patent "simulating basic physics" , I'm sure simulations for this have been written countless times in the past decades.

It's not even a simulation with say, friction (which would be simulating physics). It's literally sample code from PhysX fifteen years ago, where if you're standing on a physics object, your speed = physics object's speed, at every simulation frame.

They've been granted a patent on code so simple a CS grad with a game dev specialisation writes for class.
Being hard to use and not very useful feels like a clear design choice to me. They were too good in the previous game, so they all got a big ol’ round of the nerf hammer.

And they moved them to interactions next to the sages because they sincerely overloaded the controls of that game.

The whole game would have been better without any sages’ power.
It depends on the nature and motivations behind it. If someone has developed a new more efficient way do do something, it benefits the organization if people are made aware of it. Less emphasis on who invented it, more on the thing itself.
I don't see a null decision as political, but I think you get the point. It's OK for the tows to die, as the alternative is worse for literally everyone.
Can you be somewhat specific about what could be done with regard to the situation in Germany today?
I’ve always enjoyed trying to click the moving apps, like a little video game I get to play to break up the monotony of my computing adventure.
Yeah, I wrote CSS without Tailwind for 15 years. I don’t need it. I’m just 10x more productive with it. If you don’t want to learn new things that’s fine.
> you’ve probably known co-workers who are the “noisier cousins” of quiet quitters — they’re sometimes called “loud laborers,” a term coined by André Spicer, an organizational behavior professor and dean of Bayes Business School.

all these buzzwords are coined by "business" professors/academics whose crowning achievement is getting featured in some business insider/CNBC clickbait article. hasn't worked for a company or startup his entire career, just focused on writing self help books. their entire career is parading around whatever flavor of the month business jargon is popular with the professional–managerial class
"...it[using a CDN] also has downsides when it comes to privacy, security, and systemic risk, and it may actually be slower in some common cases. Here are some reasons not to use a javascript CDN, and some alternatives to consider instead."
For run of the mill meds, my doctors haven't mentioned considering price, but for an autoimmune issue that required very expensive medication, my doctor helped me participate in a manufacturers program that covered anything my insurance wouldn't over $50 a month.

As it turned out, my insurance wouldn't cover it at all, because they wanted me to try a cheaper, older medicine that had a much worse list of potential side effects.

If it hadn't been for my doctor, I wouldn't have known about the aid program or to enroll in it (technically, it was through a separate, non-profit legal entity, but it still has the manufacturs name in it).
It's the folks on the right who prevent any action more than hand-waving.

I think we have to realize that for folks on the right it is a matter of Identity and not Policy. At this point their opinion or concerns should be just ignored because - 1) Addressing them will not get their votes (as it is a matter of Identity for them. A positive Policy for them will not impact their decision who to vote for) 2) Addressing their concerns just delays the inevitable (the inevitable could be either a significant move to renewables or climate disaster)
Scripps Oceanography retires seagoing research platform after 61 years
> These days I'd rather develop on Caddy than Nginx.

do you mean develop on Caddy itself or use Caddy as a webserver for a website you're developing?
Sorry, but they will not find it. At best ME/CFS has a polygenic cause but unless they are also testing for nutrient deficiencies this will come to nothing.

The cure can only come from personalized medicine, looking at the individual, not looking for a common cause.
> The very people in that very local community!

This is mostly how Reddit moderation works, each subreddit is one small community with local moderators.

I generally agree that this approach to moderation is much better than some universal moderation. OTOH, small communities are often playgrounds for petty dictators.
Save and star a "Recently viewed" filter like

order by lastViewed DESC

and you'll at least always be able to find that ticket you were looking at earlier...
> It's a disaster. How did it get this way?

It’s called “progress” apparently, and older gray beards complained about it when we reinvented the mainframe through the same methodology.

For all of the re-use that us computer folks talk about, we surely reinvent the wheel an awful lot. I’m guessing that we have some sort of stubborn creative streak that causes it all. That’s my excuse at least.
Amen.

Staying quiet and focussing on good work because
"it'll speak for itself" is naive and in general
the result is only to be taken advantage of.

Yeah. I suspect I'm like most engineers in this regard: staying quiet and focusing on work that "speaks for itself" is my default mode of thinking and working.

But it is just an absolute disaster. Management certainly does not understand what you do. And if your skills are above average, your coworkers doing the same exact job may not even understand what you do.

If you come up with a clever solution, you need to promote it. You don't have to "brag" but you do need to tell people that you e.g. came up with an optimization that makes the thing go faster and you probably need to show your manager a graph demonstrating the thing you did.

If you think this is dumb, I don't blame you, but that is how things work.

If you want to fight this reality to some small extent, you can work hard to recognize your coworkers' achievements and clever solutions and promote them by word of mouth, to your manager, etc. If everybody did this then people wouldn't need to self-promote so much.
I'm not familiar with that area, but considering it's not coastal it seems hard to believe the water is simply wasted once it goes into the ground in the lower Colorado basin.
Named after Deborah and Ian (Deborah was his girlfriend at the time)
> Do we prioritize agriculture or human use?

All this water is used by humans. Farmers, and the people who eat the food they make, are all humans.
It's not so much the other VPN products out there, rather no time and no other core developers. There have been lots of people contributing, some much more than others, but usually it was just to scratch their itch, after which they move on (which is perfectly fine).

I'm not sure how to revitalize development if there is not a large interest from developers, and I don't want to turn this into something commercial like OpenVPN did.
How does HTMX work with Tailwind? If I return some HTML from my backend, then the Tailwind scanner won't have found the css selectors, so it won't be in the generated CSS.

What am I missing?
Linus Tech Tips' employee talks about the toxic work culture she experienced
Should timid people refrain from using the internet altogether?
I may have misunderstood, but I think GP's point is that the ideal number of jobs for any productive endeavor is zero, i.e. "fully automated luxury gay space communism". If technology advances to the point where it's the equivalent of waving a magic wand to get energy, food, and resources, that's the ideal state.