skysight-inc/HackerNews huggingface dataset:
> By reading this website, you agree[...]

You saying that I agree doesn't mean that I actually agree. Also, putting that silly legalese at the top of the page is pretty annoying, for what turns out (after a dozen paragraphs) to be a chatty book review.
Whole genome sequencing of some kind, preferably one of the newfangled long-read technologies such as Oxford Nanopore or Pacbio, would be best for looking for novel insertions into the genome.

However, this is likely to be a fool's errand in this case, because this kind of sequencing normally assumes that we can take a sample of many cells from the body, and that all those cells have the exact same DNA changes. If you have a mutation that is induced in a parent or the single-figure-cell stage of embryo development then that will be true, but for DNA modification by a virus in an adult it will not be. Each cell will have a different insertion. Now, there are some techniques that can sequence the DNA from a single cell, but they don't give quite as good quality data, and because you'd be wanting to sample a good number of cells to see what the distribution of insertions is, it will likely also be very expensive.
fwiw, OpenZiti is permissively licensed under Apache2.0 as well. I work on the project.
Watching the world burn down around you while you contemplate how, for one brief, glorious moment, you garnered a lot of clicks. That's the life.
That's useless information by itself. The only reason this is a "repo" is because you're trying to collect developer emails.
Bootstrap and its newer counterpart Tailwind have been around collectively longer than a decade, and I can't see any reason why their popularity would die down. It's easier to learn, quicker to write, and reduces a lot of issues that arise from poor CSS. I can see why some people aren't a fan, but those people seem (from my perspective) to be either luddites or people who misunderstand Tailwind. When you have people across the entire spectrum of experience who find writing styles faster with Tailwind, I can't understand how people find themselves on the opposite side of the argument without having some underlying bias or no practical experience utilizing Tailwind.
Interesting argument. I have actually seen many news websites with huge inlined CSS in their <head> tag.
https://www.eurekalert.org/news-releases/995593

Analysis: Most research on PFAS harms is unpublicized

... significant links between PFAS exposure and risks of preterm birth, ovarian and breast cancers, osteoporosis, and gestational diabetes ...

https://news.ncsu.edu/2023/02/pfas-can-suppress-white-blood-...

PFAS Can Suppress White Blood Cells’ Ability to Destroy Invaders

https://pubs.acs.org/doi/10.1021/acs.est.2c02765

Outside the Safe Operating Space of a New Planetary Boundary for Per- and Polyfluoroalkyl Substances (PFAS)

https://phys.org/news/2023-05-secret-industry-documents-reve...

Secret industry documents reveal that makers of PFAS 'forever chemicals' covered up their health dangers

https://apnews.com/article/science-climate-and-environment-g...

EPA: ‘Forever chemicals’ pose risk even at very low levels

https://www.theguardian.com/environment/2023/may/12/pfas-for...

Societal cost of ‘forever chemicals’ about $17.5tn across global economy – report
BUT HAVE YOU SEEN MY TECH STACK?
Thinking about Functional Programming
> That seems pretty crazy to spend US$100k on a vehicle with a new technology.

He bought the car for US $55,074 (inflation adj:$71,805 per article)
How do we save water: Stop growing alfalfa in Imperial County
Isn't there already fractional scaling support for wayland? I'm using sway and always used "MOZ_WAYLAND_ENABLE=1" and firefox always ran under native wayland without blur (like on XWayland).
Jose has written about this before https://news.ycombinator.com/item?id=34935952
Clicks = money. It’s not always a grand scheme, only sometimes.
This sounds like IQ testing which I thought was illegal (in the US)?
My Dad's doctor was wonderful he worked with drug companies and was able to get my Dad's medication heavily rebated to the point his health coverage covered the difference. Anything else could be claimed on taxes.

Dad would have had to pay about $40K for Esbriet (for IPF a lung disease), and $1,700 per dose once every two weeks for Humira. And other drugs too like morphine, prednisone, laxatives and so on. But basically it ended up being almost $0.

Doctors do and can help a lot with drug costs. At least here in Canada the US who knows doctors probably get more in drug sales than anything.
The market is pretty tough nowadays, so it might be some of them stopped hiring in Europe.

Anyways, will re-check them one-by-one tonight. Thanks!
It’s one more, so it must be better
CSS is moving so fast these days, can Tailwind keep up?

I see loads of comments in here using things like `.mb-sm-3` (I presume it's `margin-bottom: 3` for small screens?) as an example for how readable the classes are, but with CSS introducing logical properties I wonder if Tailwind's syntax needs to update to accommodate those changes? Using logical properties, this same example would render to `margin-block-end: 3` and already you're moving away from the easy-to-remember shorthand Tailwind created. If Tailwind's syntax needs to update, isn't that a pain in the ass to maintain?

This is just one example, but CSS is introducing loads of new stuff every few months it seems and I would hate to be limited by the constraints of a CSS library when browsers are capable of achieving so much these days. I enjoy learning CSS, not Tailwind.
This phenomenon is mostly just GPL-phobia. Microsoft spent billions in the 90s to convince corporate legal that the GPL is "viral" in ways it is not. You could simply rename the license to something other than the letters G-P-L and this would go away.
Tailwind is made for a component world where reusability is at the template/component level.

This also covers both scoping issue with css: the usual issues with the single global namespace for classes and the unlimited depth of the descendant selector.

That is even with scoped classes if your app has component nesting as <A id=1><B id=2><A id=3></A></B></A> then a selector like .A_box::hover .A_btn will select the class A_btn both in <A id=1> and <A id=3>.

Tailwind solution is to manually or programmatically apply the relevant style in your template.

The whole idea being that the unit of reuse is not the class name but the templating component.
It takes hydrogen that can only be refilled from a specialized hydrogen station. It's in the article.
Oh, I wish it was that simple.
A GUI for Yt-dlp written in Rust
Their angle is SSO and 2FA for auth, targeted at enterprise customers who often need to meet compliance.
I know you don't care, but making people feel bad on purpose is bad.
It likely uses liquid hydrogen for fuel which can be difficult to come by as there aren't a lot of fuel stations that have that available. I found this video interesting and informative and it goes over some of the pros and cons of owning a hydrogen powered car - https://youtu.be/rtZQLUtckS4
One good way to get your comments deleted and your account banned is to spam the same copy/paste rhetoric to three stories in a row.
Doctors are in the business of helping people get healthy. And unfortunately in the US this is tied very tightly with finances.

If a doctor in the US wants to be great at their job, they can’t ignore the financial component of their work — obviously some exceptions here like the doctors who work fee-for-service on the rich.
Digital copies are linked to one account, physical copies can be shared freely.

Don't buy digital, it's never worth it.
Language is not rigorous and logically correct.

Unless you're planning to demand your users only use one particular language only a well defined subset of it.

Using a theory as a comparison is generally a pretty poor example as we have no universal theory that defines everything, instead they are targeted at only a small slice of 'something'. Language has a larger scope than that.
OK, but room/board/tuition is not a loan. The college is determining a discount, not the ability to pay back a loan.
She bought digital and I can play it though.
I think that was when Jobs was deciding to bifurcate Apple's product line into the Pro and Consumer. Obviously the iMac was Consumer ... Apple would still cater to the Pro market, the creatives, but the iMac was not that machine.
Also just happened in Israel recently:

https://www.cbsnews.com/amp/news/israel-megiddo-mosaic-outcr...
The essence of the bitter lesson is that the less inductive bias we try to bake in, the better performing they tend to be.

Transformers are preferred to ConvNets these days in Computer Vision despite the latter having all sorts of vision based inductive biases.

GPT-4 has not been trained on all text lol
I think in the case of LLM inference the main bottleneck is streaming the weights from VRAM to CU/SM/EU (whatever naming your GPU vendor of choice uses).

If you're doing inference on multiple prompts at the same time by doing batching, you don't take more time in streaming. But each streamed weights gets used for, say, 32 calculations instead of 1, making better use of the GPU's compute resources.
Quoting: "We cure childhood disease and population booms, increases the breadth of the economy, consumes masses of fuel and component elements while jointly polluting everything... We destabilize the system, creating novel problems of various sclae, and it just repeats ad nauseum. It doesn't matter what system you use, as long as we're complicating things as such none of them will ever "succeed" because they require some ideal state"

Yesterday, i saw people disputing at the internet. I'd not read nor join their conflict, but made my jokes about. For today i intended to read, how and what they said.

Quoting (another Topic on HN) some Posts more: "Further: progress will occur on real-world problems that can be solved by those methods, making those applications dominant throughout society." (especialy everything looks like its natural to someone)

Jesssus! They need a pulling-horse, that dies... (-;

"Taste was bitter at the time, but it was never going to be forever. In 2018 models had 100e6 parameters, and in 2013 GPT4 has (wild guess) 2e12 parameters [0]. Conservatively that's 500% per year. At it's peak, hardware never improved at that rate and has since slowed down dramatically. So it was always going to end, and further advancement was always going to revert being driven by a neural net of some sort." The interesting question when neural net will end up driving it.

"Posits that making a huge model won't be a competitive strategy for long because it gets to expensive in terms of heavy quantization."

# ...you may also like to read about: "KYBERNETIK", "Prozessablaufmaschinen", Bottleneck... (calms)

regards...
This is wrong - Nintendo allows people who are using the same switch to play each other's games that are downloaded to the switch. It's not even labeled anywhere which account that game belongs to. My husband an I pay each other's digital purchases all the time.
WebComponents are still very much alive. :) And LitHtml is a very nice wrapper around them.
FWIW here's why perplexity is useful: it's a measure of uncertainty that can easily be compared between different sources. Perplexity k is like the uncertainty of a roll of a k-sided die. Here I think perplexity is per-token, and is a measuring the likelihood of re-generating the strings in the test set.

e.g. take a look at these two rows:

llama-65b.ggmlv3.q4_K_M.bin 4.90639 llama.cpp
llama-65b.ggmlv3.q3_K_M.bin 5.01299 llama.cpp

So for the reduction in size given by (q4 -> q3), you get a 2% increase in the uncertainty. Now, that doesn't tell you which specific capabilities get worsened (or even if that's really considered a huge or tiny change), but it is a succinct description of general performance decreases.

If you want more fine-grained explanations of how generation of certain types of texts get clobbered, you would probably need to prepare datasets comprised of that type of string, and measure the perplexity delta on that subset. i.e.

dperplexity/dquantization(typed_inputs).

I think it might be more difficult to get a comprehensive sense of the qualitative differences in the other direction, e.g.

dtype/dquantization(all_outputs).
> But then the CSS has been an agonising, unmaintainable mess on every big collaborative project I've ever worked on

That's the other thing, tools are a really poor shortcut to competency and in practice just reflect the same level of mastery that caused the initial headache except with a different set of tools.

This isn't pure. Some things are genuinely less insane than others.

As an analogy, higher quality brushes, paint and canvases will make you a better painter but buying new brushes isn't going to be part of becoming the next Monet. Consumption isn't going to get you there.

The real competency as you point out, come at higher level coherency, which frankly takes about 5-10 years to get any good at. It's a cognitive mastery that's mostly independent of tools.

People want to seek out better tools as a proxy for the hard earned talent. It might get you further but at some point, knowing what you're doing is the only way to go.

It sucks. It's hard. It's frustrating. It's always changing and it's also unavoidable.
People who want to make a fuss, because they're incapable of making anything worthwhile like science or art...
Chris Fix has a video showing how to replace all the cells on a Prius battery. It's not the hardest DIY thing I have seen by a large margin. I recall seeing a single cell replacement video a while back as well, but don't remember where.

https://www.youtube.com/watch?v=oAHaYXBFnJo

We need more right to repair and requirement to make things repairable regulations. The balance is in the wrong spot right now.
Ironically, the (electrical) engineer who had his free speech rights protected in the case was Swedish. And the (correct) argument he was ultimately allowed to make in Oregon triggered an update in international guidance on traffic light timing. So the rest of the (free) world will actually benefit regardless!

https://www.ite.org/technical-resources/topics/traffic-engin...
A GTK-based application for browsing and restoring ZFS snapshots
Sometimes there are properties in quantum systems that are measurable not because of the state itself, but because of the history of the system, for e.g. the topology that an electron travels through. A good example of this is the quantum Hall effect, where you get discrete jumps in the conductance across 2D systems in which a voltage is applied in a transverse direction. This is caused by Berry Curvature, which is the real part of a geometric tensor that describes the topology of the quantum state. The imaginary part of the same tensor is called the “quantum metric”.

In this specific case, they’re measuring a different voltage due to electrons passing through the data written in the antiferromagnet. They pose theoretically in the paper that it could be because of an effect of the quantum metric
> Essentially every industrialized country has a reproductive rate below replacement.

That's certainly true for the short and medium term.

And yet, evolution marches on.

So far, the Amish (or at least many of them) seem to be pretty successful at keeping their fertility high. I'm sure there are other, less visible, subpopulations where that is true as well.
Oh my God! They did it again! This is so awesome!
Unwillingness to admit they don't know what's happening, memes, resentment of criticism after malpractices.

Any illness with primarily neurological symptoms have a history of medical malpractice and gaslighting.

As early as 1944, an author in the Journal of Nervous and Mental Disease remarked: "The history of prefrontal lobotomy has been brief and stormy. Its course has been dotted with both violent opposition and with slavish, unquestioning acceptance."

The last recorded lobotomy in the United States was performed by Dr. Walter Freeman in 1967 and ended in the death of the person on whom it was performed.

https://en.m.wikipedia.org/wiki/Lobotomy
I've dropped books in the past I just wasn't ready for (too young/inexperienced a reader), and enjoyed them later. On the other hand, these days I feel I can gauge well enough whether it's worth my time to finish what I'm reading. Usually I do, but not always.

I get more into a book if I can allow myself a large enough block of time to read it. I had a phase where it was basically the last thing I did in my day, and I'd only chip away at 10-15 min, having to re-read pages, not getting immersed. I still like to read a bit at night but I give myself other blocks.
Post-exertional malaise is a poor diagnostic indicator, the sensitivity and specificity are quite low.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988339/

First problem, I do not have ME/CFS, let's use the Maes et al (2012) scale. 0-5 scale, 5 being the worst.

"1 means mild exacerbations of fatigue/pain/neurocognitive symptoms following exercise (either cognitive or physical)" Yep, after a longer, harder than normal bike ride I'm quite fatigued, in quite a bit of pain (bad back, knee, shoulder), and can't think particularly well.

"2 means moderate exacerbations of symptoms following exercise; 3 means severe, incapacitating exacerbations lasting less than 24 hours;" Accurately describes what happens when I do HIIT style intervals that exceed my work capacity, or what it's extremely hot outside. Dreadfully exhausted, usually have to nap, or lay on the couch, every muscle hurts, extremely sore, difficult & painful to move for 24-72 hours.

I'm not saying ME/CFS does not exist, this is just a terrible indicator.

The worst part is making it so specific obscures the large body of existing research that would provide tools for treatment protocols here, eg work capacity in athletes.
The example I go to is the Nemesis system of the Mordor games. Such a cool system for that type of game, and it's easy to imagine ways to use it in a ton of similar games.

My understanding is that it's patented, though. So no one else is making anything like it. No other experiments about what else those mechanics can do.
Clearly there is a need for better battery DRM if unauthorized repair technicians are able to work on these components!
Yeah, honestly (ignoring syntax) it looks A LOT like the original ROR ajax implementation. Having the server render a partial and swaping out the inner html to do a partial page update.
And, when the tech advances and we can start to understand the brain better and start to get information from it regardless of its state, Its owner will care.

So you're saying there's a chance it's not too late to ask for their consent?
Sure, categorizing stuff is really hard. Almost anything looks like a compiler if you squint at it.
If you think htmx is cool, check out _hyperscript https://hyperscript.org/. Made by the same people, available with htmx I believe.

After seeing _hyperscript, it looks like they may have invented that first, and a lot of people's heads exploded, so they decided to try to make a "gateway drug" to sneakily introduce _hyperscript, and came up with htmx.
Exactly. I had to have my 2004 LR Discovery 3 completely disassembled, as in - body taken off the chassis, engine and transmission out, all components stripped, cleaned put together, chassis sand blasted and redone - all in all paid about £6000 for the whole thing. The 100k euros is a "we don't want to do it" quote. I'm just surprised Hyundai quoted him anything, LR has no issues telling me "sorry we don't have parts for your vehicle anymore".
> In fact, alfalfa has become an instrument for exporting subsidized water.

efficient, too. why would anyone want to ship the supplies half way around the world when you can just ship the product? especially when the supplies are sold to you at a discount compared to the locals?
“Decent” companies?
By what measure?
"Every time someone reads a book a new book is being created."

But not only reading. Try going for a walk while thinking about some book your read some time ago. Look for the underlying ideas or story and reflect about it.

This also applies to memories. Changing, growing up, can make you change how you feel and reflect about past experiences.

I am know reading Zen and the Art of Motorcycle Maintenance while having a part time job delivering pizzas in motorcycle. It's a pretty awesome experience.
I would not disregard that direction. Architectures that do well on pointer chasing have been attempted in the past (e.g. Cray XMT) and are cropping up in prototypes (PIUMA https://arxiv.org/abs/2010.06277) and startups. The caveat is that latency is hidden with massive amounts of parallelism.

edit: To be clear, I agree with the sentiment that the paper abstract machine models are inadequate in most practical cases. There are workloads where you're dealing with asymptotically large datasets, such as genome assembly and analysis. Even there, the RAM model is abstracting away the bottlenecks of modern computer systems.
> We're already exploring alternatives. Future client projects may not use Terraform at all.

I'd wait and see what happens with OpenTerraform. If the fork gains some good momentum, it would be the easier choice. Usually, you should be okay with using the latest FLOSS version for a few weeks/months until things settle anyway.
What is github now?
"Consent" is a loaded word. I'm not sure the family/estate of a person can consent on behalf of the deceased.
EU Law Disagrees.

Feel free to Geoblock the entire market if you disagree. Many small news sites in the states do this.
The viral angle is fascinating to me.

From the article:

>Viruses can trigger ER [endoplasmic reticulum] stress, perhaps explaining why ME/CFS and related conditions often arise after infection.

Since you mention herpes, I'll bring up what I've read about Epstein-Barr (EBV) (which belongs to the herpes family of viruses). It's estimated that 90% of the global population will contract EBV in their lifetime. In most people, EBV goes dormant for after the initial infection is cleared and more or less stays that way for life. But in some people, for unknown reasons, it can chronically reactivate, triggered by stress, other illnesses, immune dysfunction episodes, etc. Apparently it loves to hang out in the spleen, although I believe it has been found to reside in other organs as well in these cases of chronic reactivation.

I would be shocked if this were the only virus to do so, but at present it seems to be the most studied, perhaps because EBV is fairly strongly correlated with a bunch of cancers, auto-immune disorders, and chronic conditions (including MS as recently demonstrated in a huge study by the VA, n=10,000,000). Very interesting and important stuff. I look forward to further research into these mysterious long-term effects of viral infection.
"Breakthroughs" are inherently hard to predict. This field is advancing at a very rapid pace. A lot of the improvements are incremental, but even these are coming very fast, and moving in different directions at once.

I don't think there's any likelihood of replicating GPT-4 on your M1 in the next twelve months, especially not if you're expecting responsive performance. What we could see are a plethora of models dedicated to doing particular tasks. Say, specialists in aspects of programming or accounting or law or medicine. Or general knowledge models with access to a local cache of Wikipedia. Individually, none of these models would have to come close to GPT-4's overall level of power and flexibility. But collectively, they could reach that level of utility.
The Extractor: a drop-in replacement for self attention in Transformers
They can be downloaded to a switch and once they are on the switch an account playing that switch can play any digital games on the switch. They don't even tell you which account "owns" the game.
Histamine is a general inflammation-inducing chemical. That pain and rash you get when you touch a stinging nettle - that's caused by the stinging nettle literally injecting histamine into your skin.