skysight-inc/HackerNews huggingface dataset:
> Of all the things that seem wrong with solving this with a pill

Is this based on any experience (clinical or research) in postpartum depression or some philosophical objection?

In case you were unaware of what severe postpartum depression can look like:

Severely ill patients often report suicidal ideation and behavior, typically demonstrate obvious impairment of functioning, and often manifest poor judgement that places the patient and others (including children) at risk for imminent harm. In addition, patients are more likely to develop complications such as psychotic and catatonic features and have a history of severe or recurrent episodes. Patients with severe major depression should be referred to a psychiatrist for management and often require hospitalization.

Source: UpToDate

> Is the FDA immune from suits if this results in a generation of damaged kids?

Sued for what? It's clearly stated in the drug monograph.

Available data from a clinical lactation study in 14 women indicate that zuranolone is present in low levels in human milk (see Data). There are no data on the effects of zuranolone on a breastfed infant and limited data on the effects on milk production.

The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for ZURZUVAE and any potential adverse effects on the breastfed child from ZURZUVAE or from the underlying maternal condition.

https://documents.sage-biogen.com/us/zurzuvae/pi.pdf

> We should compare the kids"?

All patients enrolled in the trial were asked to stop breastfeeding. It is unethical to perform the study you are suggesting and even if it were no IRB would approve per regulations.

https://www.hhs.gov/ohrp/regulations-and-policy/regulations/...
This is the tech equivalent of "we don't serve your kind here", and limits any attempt at competition.
cpython caches the small integers, and this is just grabbing a reference to 8 and 9 and then altering the value of the integer held in each cached reference.

The author could have skipped the c library and used the ctypes module to munge the bits.

There's no guarantee that any other version of python would use the same caching, same structure layout and certain not be able to link with the same c library.

So, yeah, it's specific.

A fun little adventure into how things work for the author, though.
The CPython source is really a bit of a joy to look through. The lowest level stuff is really tough, but generally it's all relatively straightforward.

Though with the specializing compiler work, some stuff is... less obvious. But I still generally find it straightforward when I want to know some detail about how the language works.
Whenever I read about the AVP being a dud, I am reminded of my own reaction to the first iphone: “it is a stupid idea and it will never catch on” whilst proudly clutching my Nokia communicator.

I think the AVP 2 or 3 is going to be great.
But its hard to beat a free tier.
Government should pay me 100% of wages for 18 years!
Here's a HN thread asking the same question: https://news.ycombinator.com/item?id=29169143

Anecdotally, I've heard the same thing. Lots of articles will say things like, "ILM increased the resolution of StageCraft with its in-house renderer, Helios" but never explicitly say they dropped Unreal or exactly what changed.
This is a literal Heath Robinson exponentiation of what would otherwise be a Kalman filter.
For me this looks fine:

var i = CustomInt.valueOf(0)
What about the incentive to release "the most secure chips on the market", are you discounting that a bit too much?

Granted that human nature tends to mean these factors don't have a high enough weight, e.g. it's not the safest airplanes that sell the most, it's the cheapest ones that meet the regulations, and the regulations drive safety improvements, for the most part
Why would "wiping the slate clean" mean anything? The behaviors that lead to the previous slate don't magically go away. Our behaviors are innate and ingrained into us one away or another (nature, nurture etc.).

I don't imagine society would evolve differently even if it started all over again, unless something fundamentally changes about the human condition or human nature.

Edit: had a question about unions, asked and answered by the article...
The fact that you think this sounds easy makes it apparent how little experience you have in this domain.
I hate these 2FA mandates. I don't use PyPI, but I do use GitHub, which has also announced a 2FA mandate.

I use my GitHub account to make bug reports, small pull requests, and silly personal projects. It is not that important. I want to sacrifice security for convenience on it, and that should be my choice.

I also do not agree with the argument this secures the supply chain because:

1. It ignores supply-chain attacks from people who already have repository access.

2. Most big companies (ie. Google) are probably already using 2FA.

3. And if people are automatically pulling code from random people/groups without checking it... maybe that's what actually needs to be banned.
That's typically deployed on sites under heavy DDOS attacks. Nobody wants for their users to see that, they are forced to.
It's already labelled for breastmilk excretion.
> We are saturated in your news, your media, and your politics.

That's my point. Why not saturate yourselves with your own news, your own media, your own politics. Canada surely must have something going for it?

> You honestly think that people living half an hour from the border don't get an opinion?

I'm not far from the canadian border and I don't a shit about canadian politics. You don't have to obsess over foreign politics. You'll live longer.

> When did americans get in the business of licensing who could have opinions, anyway?

Since 1776?

> So much for the land of free speech. RIP

Chalk it up to foreign meddling.
> For industrial control, developing high-performance controllers with few samples and low technical debt is appealing.

They then proceed to develop a nine-stage pipeline of three interacting processes relying on a separate database in order to perform prompt generation.

As an aside while I remember its genesis I now have no idea what technical debt means in popular use. These authors use it to mean investment of effort.
This is such a lazy comment and the fact that you didn't copy paste the paragraph that followed makes me think you have some agenda to push.

"The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for ZURZUVAE and any potential adverse effects on the breastfed child from ZURZUVAE or from the underlying maternal condition."
This is an interesting question. It begs for an essay on the topic of respect: when, why, where and how. Thanks for the writing prompt.
Hmm ... I haven't looked at Urbit in years, but this doc was pretty well written -- and it makes me curious about a Unix-y and loosely coupled version of the system.

It always seemed a big no-no to couple the VM and OS to the language. Language diversity is a good thing.

What would it take to build something with the interesting properties of Urbit on a more normal, not-purposefully-obscure stack?

As far as I understand, Guix has deterministically built the whole ecosystem from a 357 byte bootstrap

https://guix.gnu.org/en/blog/2023/the-full-source-bootstrap-...

OK so now you have, C compilers, Python, JavaScript, etc.

---

Now what do you need to do to Linux? Do you need to get rid of time() and rand() ? (Not sure if Urbit is functional like that)

---

What about the networking? The whole network has a single state?

So is this like if you had all of these separate Linux systems all writing to one big distributed git repository or something? I never really understood how the networking is done.

---

This leaves the identity parts; I would also leave out the crypto parts too ...

But as far as language / OS / networking, I'm sorta interested in what a "conventional" system of this type would look like. I actually think it has some practical applications for some kind of functional distro like Guix (since these distros all become networked systems eventually -- they are not really single-machine systems)

I also wonder if this already exists -- are there "non-obscure" and "non-ideological" systems like this? When you add some language diversity, it becomes more interesting to me.
Beautiful lading page and generous app. Thank you for making tools like this that help small-time creators improve their margins :) I used Payhip for my last project but I will bookmark this one to make sure I use it in the future
I'm sure we can all agree that Cargo is the best thing since sliced arrays, but I've finally reached the point where we have enough different Rust projects at work that rebuilding the world from scratch all the time and having ~40 GiB `target/` directories scattered around the place is getting old.

I'm not meaning to criticize Rust or Cargo here; they're both doing their jobs just fine. But I do find myself craving a different compromise for much of what I/we use Rust for today. And I'm really hoping that Wasm Components (and WASI) will be that different compromise — e.g.:

- Don't rebuild an entire HTTP stack from scratch for every tool that happens to use HTTP.
- Therefore most projects won't have enormous `target/` dirs.
- Reuse components built in CI for Linux directly on a Mac dev machine (cross platform).
- Mix and match new processor architectures available in AWS without building two versions of everything.
- Also reuse some components in the web browser (yes, we actually have real, boring use cases for this).
- Wait, I'll be able to do all of this and still be writing Rust? Shut up and take my money.
7f3d42342ecb4d7f
I signed up when it was new. It used to be you got a 'ship' which was a 12 char string that was essentially your IP/DNS/identity. Then later they changed it to 'planets' and you had to re-register again.

Then they moved it all to Ethereum in 2018 but I had stopped giving a shit so I don't know what happened after that.

I should also note they did an auction of address space prior to Ethereum, seemed like they were trying to get in on the crypto grifts. It's all completely incomprehensible to me even though I used it for a good year or so lol
No of course the FDA won't get sued because it literally lays out the risks. That's their job.
As a large language model I’m unable to physically turn the lights on. However, you can get your ass up and turn them on yourself.

Is there anything else I could help you with?
O.O
Is there an easy way to report false positives instead of having to attract the attention of an employee on social media?
I had to watch several videos on youtube to answer this question for myself. The advantages to using ChimeraOS over big picture mode seem to be tied to Valve's gamescope compositor, which gives you access to a nice UI for limiting framerates, applying mangohud, and choosing upscaling settings. ChimeraOS also has compatibility with Steam Deck plugins.

I know nothing about the plugins. You can definitely do all the other things outside of gamescope's UI, but... it actually is a pretty nice compact UI.
Ups Drivers at 6 Figures Spur Job Interest After Teamsters Deal
Related: one of my favorite StackExchange questions: "Write a program that makes 2+2=5"

https://codegolf.stackexchange.com/questions/28786/write-a-p...

Really shows you the skeletons hiding in some languages. My favorite is Haskell, which will happily do what you tell it to.
That’s clever, but illustrates something not widely appreciated:

When you import a module, Python executes it. For instance, `def` isn’t syntax that says “hey compiler, this is a function!” It’s a statement that’s executed at runtime to define a function. You can put any code you want at the top level of a module and it’ll get executed when the Python interpreter gets to that line.
interesting. wonder how they'll handle large amounts of sync.
> Weight distribution - The motor weight is located at the wheel, improving handling.

That's surprising. I understood that increasing unsprung weight was held to be a bad idea.
This sounds awesome. Could you share some examples of logs you have?
What I worked on for Go 1.21
That's wild. From Wikipedia[0],

>...gin factory in Bow, London, so industrial scale production of acetone could begin in six British distilleries requisitioned for the purpose in early 1916. The effort produced 30,000 tonnes of acetone during the war...

Evidently, he delivered exactly the amount Churchill requested. That is an incredible feat to go from bench to industrial scale within a couple of years. Was there any other putative process on the table at the time or was the entire acetone effort dependent upon scaling up Weizmann's process?

[0] https://en.wikipedia.org/wiki/Chaim_Weizmann
Chinese economists told not to be negative as rebound falters
https://archive.ph/aC8rM
Good question I guess. It's not fixed by being surrounded by a village. A village helps, but if you've never experienced PPD before then let me elaborate. PPD at its worst can bring psychosis. Read that again, psychosis. This is not something you can hug to make better.
Work in the sector and once the investigations / fines came out massive notifications went out across the board reminding everyone not to use unapproved comms.

Was this used for nefarious purposes - possibly - but more likely it was general communications between team members using a platform that is more comfortable to them than either 1st party tools or something approved like teams. 99.9% of this was likely reminders for meetings, attendance and coverage messages, a message to a team member who timezone shifted from you and may be off any you need an answer etc. I'd guess most people involved didn't even consider the record keeping because their day to day jobs don't involve actual trading info, and the "encryption" of those services likely made them feel a more comfortable than they should.

Not trying to excuse the behavior - yes the record keeping is important - but I think it's also important to realize this was likely largely innocent.
pypi doesn't require 2fa to upload.

They use 2fa to login onto the website and make you create a token. After that you just save the token within your project and have a script to upload new versions.
Maximum mutational robustness in genotype–phenotype maps
There are other writeups of it, but this link seems to be the source paper. Here is a popular summary:
https://www.news-medical.net/news/20230808/Unexpected-link-b...
The whole planet is a cemetery if you really think about it.
Good lord. I'll never understand why people promote this project, since it's main feature is that he's doing it wrong. The complexity he's trying to avoid exists for a reason, not because people like complexity.

OP: post here: https://lists.debian.org/debian-jobs/
Canada’s historic wildfire season only halfway done
Garmin is unfortunately in the middle of phasing out all their transreflective displays. The newest generation of their smartwatches (265/965/Epix) are all using OLED, save for the Fenix 7.
Maybe science has a formal process somewhere but it is mostly an open ended iterative exploration of ideas, especially around emerging fields.
I think the amount of news we expose ourselves to should correlate more with the closeness of the events (or inversely with their distance from us). We can actually have an impact on events in our local community. And in a lot of ways what is immediately around us when we walk out the front door has a more impact than anything else on how we experience the world.
News from far away is just second hand sadness.
to be fair, not even all iPads with USB-C have the same behavior. (The fancier Pros are Thunderbolt/USB 4).
You mean it uses `operator bool` where `bool` is the target type of the conversion, yes?

I have no problem with the idea that conversions are operators. My point is that the title suggests something far more general that what the body of the article actually discusses. If the title had said "Implicit Conversions" rather than "Implicit Operators", it would have been much clearer and I wouldn't have commented.
For drugs approved between 2011 and 2015 the FDA approval time was a median 303 days, faster than the EMA at 369 days.[1]

For drugs approved between 2000 and 2010 (for all 3 agencies, the FDA gets more applications) the FDA approval time was a median of 268 days, faster than the EMA at 356 days and Health Canada at 366 days.[2]

Based on your assertion and the data this means that you think all three of these agencies are harming the population, with the FDA being the lesser of all evils, by not approving drugs fast enough. Do you have a source for this claim?

[1] https://www.nejm.org/doi/10.1056/NEJMc1700103

[2] https://www.nejm.org/doi/full/10.1056/NEJMsa1200223
Benzos directly hammer on GABA receptors while pregnanes use G coupled progesterone receptors to transduct signals to the GABA system.
You have to use judgement to figure out what's worth investing your time in.
Funny how things come around again and again.

Fortran had basically the same bug, fifty years ago. https://softwareengineering.stackexchange.com/a/254921
Ok I've changed it to what the title says at the moment. (Submitted title was "UPS drivers in US to get $170k pay package" - possibly BBC had that earlier?)
> hoarded wealth and insular investing/cash outs destroys all other classes of labor until everyone gets fed up and start destroying each other

Declining prosperity in the lower/middle classes is a recipe for social/political discord. If prosperity is increasing, the more privileged half is less likely to fear losing their status, and minorities and the underprivileged feel like they have a fighting chance at a better life.

Take that away and people get crazy.
Ashes to ashes, funk to funky.
One thing I would love to see is for Unity to catch up to Unreal when it comes to virtual studio applications. So far as I understand, there's no technical reason that people couldn't be tooling Unity to do the next Mandalorian.

Heck, even NerdForge used Unreal to create their virtual window on their new set. https://youtu.be/Vg1TGADF248?t=880
Fine with me!
>an effective solution I've found with minimal friction is to fully use the mailto protocol scheme.

This is another assumption that I am not so sure is valid anymore: that there are hordes of bots out there scraping every email they can find.

My personal website has had a raw mailto "Contact" button for several years now. Earlier this year I changed that email to an address I only use for the website (it's an alias) just as a way of tracking what comes through, and I have not received a single spam email to that address. Maybe I am tempting fate by putting that out there, and some asshole is going to try to ruin it for me. But it's my experience.

I'm more likely to get an email from a recruiter who has used a tool to scrape my email off of Github (though I've made that significantly harder plus nobody wants to hire programmers anymore the ultimate spam control!) than an email from them having clicked through to my website and using the Contact button.

I've gotten several real people sending me legitimate emails through it though. Sometimes they read something I post here, or they find a post from Google. Or it's someone I haven't talked to in a long time and they don't have a current email for me but they are able to reach me via my website.

Here's some cold emails I've been sent over the past 1-2 years: https://i.imgur.com/rMfOqb2.png

My website isn't big, but it is fully indexed by Google and other search engines and has backlinks. If the internet was really this dark forest where there are masses of bots out there ingesting every email they can find, surely I'd have gotten something by now.

I don't research this stuff, I can only share my anecdotal experiences. But it makes you wonder, right?
> Postpartum Depression holistic patient view versus commercial pharmaceutical treatment.The shear emotional, physical and life changes involved in having a baby is in many ways similar to PTSD. In just a few weeks your body has been physically exhausted, your mentally and emotionally drained and now you are physical/spiritually/ and emotionally bond to a new human life who is 100 percent dependent on you for its survival and well being.Now imagine this leads to a period of depression in the patient. Is this really a pharmaceutical issue or a societal structure and support issue. Perhaps even more than just that.It is depressing to me to see things like this get pushed out … just take this pill and it will help move you up a few points on our 17 point scale and cope.Instead of wow, let’s really look at what’s happening with the birthing process on how we prepare mothers and support them emotionally, physically and maybe even spiritually.Nope just take this drug and in 6 weeks you will be back to work and we can get that new kid in daycare :/#rantover
One of Dave Allen's many graveyard jokes.

https://www.netfunny.com/rhf/jokes/88q3/12856.html

https://www.youtube.com/watch?v=BqbEMmI78HY
Superconductor research is fraught with failures when looking back at previous breakthroughs, it's just history repeating.

Asianometry recently did a video on the history of superconductors where this topic is clearly presented:

https://youtu.be/wUczYHyOhLM
Their blog is a hilarious adventure through all the Pine* items they've released, their eInk venture and the earbuds are particularly interesting to me...
Agreed. This is further warming, and we have made it worse.
What sucked about the school?
Is social media making America’s murder surge worse?
Not OP, and I don't understand Urbit particularly well, but I think this part of the doc is the salient feature:

> The data model of Nock is the noun (*), which is either a natural number (@, called an "atom") or a pair of nouns

> The noun is famously simple; it competes with the list as the simplest possible recursive datatype

All code and all data is like that. So to me it's basically a Lisp-y networked operating system.

This also makes it very inefficient, which the doc explains. But the idea is to build everything on top of the most minimal axioms, which never change.
Alas, my new phone doesn't transcribe/edit quite the same as the old one.

Awl sew, thee spiel checquer frowned know tissues bee four eye clacked.
Yes. There's a limit to how much people will take but usually people are wiling to put up with a lot.

One example is my ISP, they have an awful customer service portal... but honestly? It's rare when I see any service that has a good customer service portal. I have worked developing software for smaller companies, precisely this kind of software. Our stack was totally bloated and it was really annoying to work with. But there's certain... expectations? You need to justify the dev time.
The heavily layered jargon extracts a commitment from true believers and creates a boundary between those who “get it” and the rest of the world who hasn’t seen the light. It’s not so much a platform to use, but one to proselytize.

In this it’s closely related to Scientology and cryptocurrency. Urbit is a distributed computing platform in the same sense as Scientology is a mental health program, or Bitcoin is peer-to-peer electronic cash. Sure, there’s technically someone using it for that, but for most people the value is in the social belief system.
My (relatively unbiased and informed) summary of what urbit is from the last time it came up is here: https://news.ycombinator.com/item?id=31124343

As someone who thinks urbit would solve an important use case but is too hopelessly weighed down by the stench of its founder to go anywhere, a good fork seems is a reason for optimism, so best of luck Plunder team!