skysight-inc/HackerNews huggingface dataset:
> People are rightly highly suspicious of Big Pharma.

Absolutely, but that should only trigger scrutiny which in this case would provide several answers for why this is a good thing and not a BigPharma scam.

> efficacy over older cheaper drugs (like Alprazolam and Zolpidem/Zopiclone).

This drug, and the IV formulation it is based on (Zulresso), are not the same as and have different mechanisms from sedative-hypnotics which as an aside are not indicated as monotherapy for PPD (or any depression, don't give a downer to someone down). The mainstay of treatment is SSRIs.

This class (which is the only FDA approved drug class for PPD) is an analogue of the endogenously produced metabolite of progesterone and the mechanism is not fully understood.

To your point of head to head trials, you are correct they do not exist at this time and will eventually be done however all of these are still new.

What we have right now are indirect comparative analyses which while limited show stronger magnitude effects than SSRIs.

https://www.frontiersin.org/articles/10.3389/fphar.2022.9500...
Almost none of what you've claimed is true.

There was a large gap between discovery of HIV in human populations, including people getting AIDS and dying of trivial infections due to their immune systems being wiped out. Once people started looking deeper it was also discovered that it was far from a "gay" disease. All of this happened before a single human tried AZT for an HIV infection.

Beyond all the scientific evidence we have real world Darwin Award trials: various HIV denialists infected with HIV have refused to take drugs to treat HIV and they have died. Others got very sick and were cured almost immediately after starting standard treatment.

We also have numerous clinical cases of people with undiagnosed HIV infections getting sick from common bacterial/fungal infections, get diagnosed as HIV positive, start the standard drug regimen, and their problems go away.

Not to mention SIV (the simian relative of HIV) causes an AIDS-like disease in some primate species which gives us both another line of direct evidence and almost certainly the original source of HIV.

You're just plain wrong.

We can squirt HIV in a dish and watch it kill the normally unkillable T cells. We know 100% what happens when your T cells collapse: your immune system stops working and some normally benign organism takes over your body then you die. We've sequenced HIV. We know how it mutates so rapidly. We know why it is able to attack T cells.

There is no mystery and no need for conspiracy. All lines of evidence point to HIV as the culprit.
>"It doesn’t matter how amazing your product is, or how fast you ship features. The market you’re in will determine most of your growth. For better or worse, Gumroad grew at roughly the same rate almost every month because that’s how quickly the market determined we would grow".

This speaks to me a lot, saw the same thing in asset management over the last decade: Most of the smart, alpha focused strategies that demanded a lot of effort and mastery of the markets ended up losing out to simply getting a lot of beta in the portfolio and not touching it too much.
Makes you wonder how people manage to bring up kids in London
Some of their practices are, my gripe is with the “all” quantifier.
Canonical’s recruitment process is long and complex
As I predicted, public money of the European Chips Act will flow to the big guys:

https://pr.tsmc.com/english/news/3049

"with the final investment decision pending confirmation of the level of public funding for this project. The project is planned under the framework of the European Chips Act."
One possibility nobody mentioned yet: the chip vendors don't invest a ton of time looking for them because they don't actually matter that much.

Bear in mind, security researchers are incentivized to find things to build their reputation. It's very often the case that they claim something is a world-shaking security vulnerability when in reality it doesn't matter much for real world attackers. Has anyone ever found a speculation attack in the wild? I think the answer might be no. In which case, why would chip vendors invest tons of money into this? Real customers aren't being hurt by it except in the sense that when an external researcher forces action, they're made to release new microcode that slows things down. Note how all their mitigations for these attacks always have off switches: not something you usually see in security fixes. It's because in many, many cases, these attacks just don't matter. All software running on the same physical core or even the same physical CPU is either running at the same trust level, or sandboxed so heavily it can't mount the attack.
Seconding the bangle. Great battery life, good ecosystem, very hackable. Not a replacement for an Apple Watch or people, but very capable.
By and large, by now, mask mandates were dropped everywhere.

There never was a reason to do this. Aside from politics, of course.

This, as this study shows has massive costs in the quality of life for many and affects the economy but no. We can't have mask mandates.

I am now wearing a Cleanspace Halo when on public transit or indoors. If y'all can't be bothered to keep the air clean I will make my own. fine But what of the many who can't afford one or find it ridiculous to wear one? Because it is ridiculous to basically constantly cosplay as Darth Vader (badly), no question about that. But what can one do?
Cost vs benefit.
This is one of my gripes about kids being online - every platform has some different setting for parental control and screen time whether its google, apple, PS or nintendo

Id like to see some consistency where i can link my Google Parent Link to Apple - and it automatically applies those settings under another platform

Its not like Im using the ipad or console for baby sitting - but its the balance between allowing children to experiment vs their own safety.

Its really frustrating
Moreover, the PDF of an opinion usually includes the actual opinion, and all the concurring and dissenting opinions, in a single document, so the actual opinion is usually much smaller than the whole PDF.

(While reading the concurring and dissenting opinions may be useful, they are, in effect, other important people’s opinions on the opinion, and not necessary to have an basic informed opinion on the opinion.)
Google only lets you use app-specific passwords if you have set up two-step verification (and provided a phone number).

If you have an email client that doesn't speak OAuth and you can't/won't set up 2FA then this proxy of mine lets you use any IMAP (or POP/SMTP) client with an OAuth email provider, regardless of whether it supports OAuth 2.0 natively: https://github.com/simonrob/email-oauth2-proxy. No need for your client to know about OAuth at all.
Probably pushed by some recently rotated manager or new CEO dropped out of a recent acquisition...sometimes the code pushes the system over critically, sometimes it's just a code broken arrow event. Something to tell in the privacy of your next off the record interview or in your biography...
it 100% depends on the project and is demonstrably false for many things I participated in. For example, if you are a fintech integrating with a bank - which is very important for moving money cheaply and being able to make the ends meet - like 80% of the work is bullshit meetings and compliance and beating things out of like 30 different 9-5 idiots somewhere on the East Coast, which I would be ecstatic to delegate to a manager or a PM, who can run the whole project, track the timeline and answer the endless questions about when it's going to get done already. On other projects with less human dependencies you really don't need one.
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I don't think an LLM is capable of this kind of sarcasm (yet).
I read this in a much more amusing way before I read the article.
I really don’t understand what people are gaining from telling others what to do. Flexibility buys freedom for all employees to live the lifestyle they want. As long as it does not impact your goals or your employers goals I don’t really understand what the real issue is here.

If the shoe were on the other foot how would you feel if someone forced you to be remote?
yes. i am indeed free to discuss the same with the current nigerian prince. (/s obviously)
I wonder if posting photos from Kabul celebration three years ago may be incriminating for its participants in the current political climate.
Why do you think that was an acceptable comment to make? Read the room.
It’s worth reading about refineries and chemical plants. We’ve all heard of Bhopal and other disasters but it’s worth bearing in mind just how few disasters happen in these fearsomely complex and dangerous plants. Almost all are managed successfully by the private sector.

There was an interview with Jim Radcliffe recently in which he described Ineos’ approach to safety. It’s a variation on what’s described my Steven J. Spears in his case study of Alcoa. The truth is that the private sector has innovated much of what’s best in modern safety practice in a way that has made monumentally dangerous industrial processes routine.

There are perhaps good reasons to keep nuclear weapons management in the public sector. Canards about the safety record of the private sector are not though.
Me learning the basics:

- how to pass in arguments and parameters

- how to get help on any command

- how to handle whitespace

Tools:

- good autocomplete

- command history list with filtering (what I hate the most when using CLI is researching again how I did something a few months ago)

And realizing it's basically a REPL environment. Your programming skills transfer to CLI.
Cholera and Polio were much more severe illnesses than Covid and water is much easier to treat than air. I’m not sure where you’re getting the mission accomplished attitude but from what I can tell it’s simply an acknowledgement that the risks have reduced to an acceptable level, and the costs of doing anything much different are too high.
> 99% of voters will never read any of that crap

Yes, and they are entitled to a vote that gets aggregated with others on the issues and candidates subject to public elections.

That’s different from them having an opinion that is worth listening to individually.
*If you are lucky
Not really. Rust have had backward compatibility problems already during its young life.

Why do you think you need to specify release and nightly to successfully build some projects?
A dead comment thinks you're making a no true Scotsman argument, but you're right. The key is that the workarounds you're listing are very cheap and easy, not just possible.
In 2016 the split between college educated voters was 49-45 and the majority of white college graduates voted for Trump.

Some college educated white voters shifted to the Democrats in 2020 so the gap was a bit wider so I wouldn’t say “incredibly” unless you think 3% is incredible..

It’s a different matter for postgraduates though (62-37% in 2020)
Without any data, I suspect the incidence rate of PPD is unaffected by social factors but having a support system definitely helps mitigate the effects on the family (i.e. more hands to help with the baby). Fortunately my family has never had to deal with it but it's definitely not some minor illness for people.
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sure, that was my idea for a while as well. My problem is that I live in a big city. And bike theft is a real problem.

I would have loved to build me something around a Rohloff gearbox with a belt compatible frame, but that thing would set me back at least 2k EUR / USD. By comparison, my current commuter setup is a combo of two single speed bikes (one light, one with racks for more cargo / shopping capacity), either of which I got used for 50 and 100Eur respectively. And my current bikepacking bike is a 1200EUR steel Kona with some extra components slapped on top. Basically, I've got 3 bikes for 3 diferent uses for a price of that gearbox one.
Ok, though most of the time this isn't the kind of thing that changes.
Meta disbands protein-folding team
https://archive.is/s59wP
> Yes, my elderly mother can’t stop complaining about how much crime there is “these days”. Despite the fact crime per-capita has decreased, the news reports the absolute value. This in turn tricks people into believing something that is quite literally opposite from what is really happening.

This has been true consistently since the major drop in crime rates in the 1990s. (And it was true for particular kinds of crime that were declining well before that.) This isn’t a new effect of todays news that differs from decades past: “if it bleeds, it leads” and the effect that has is much older.
Is this based on a sample from the original lab or a new sample they synthesized?
White college graduates are almost evenly split between the parties..
Yeah, those religious fundamentalist ideologies have no place in a modern, civilized society.

My issue with the Progressive "tribe" is that it looks at the other tribes, concludes to some degree correctly that they're a bunch of illiterate fascists, and then declares that anti-capitalist economic leveling and socialist reeducation are the only possible cure. Their small-d democratic credentials are hardly better than those of the guy with the horns.

It's been about 15 years of social media, and it's hard not to take it as a gauge of true political sentiment at this point. There aren't a lot of other outlets where we get to hear what people are thinking. But I do go to a lot of bars, both in deep red Oregon country and in ultra-blue Portland, and I'm not actually on social media, so I'm basing this off what I hear from people in person over a drink, not stuff I read on X/Twitter.

Simply put:
In PDX, I own two cars, I'm evil.
In Salem, I'm a Jewish liberal, I'm evil.

I've come to the conclusion that they're all idiots.
The same amazing guy also published the Pure sh Bible:
https://github.com/dylanaraps/pure-sh-bible
Not sure what your communicating. I wouldn't say anything. I didn't say they couldn't ever get anywhere.

My point is that people reason. But they are probabilistic. And they solve hard problems, and still make mistakes on simple problems. Or even fail a problem they solved before.

Holding language model reasoning to higher standards than the kind of reasoning humans do (and that they were trained on), seems unreasonable.

Neither language models or humans are deterministic mathematical deduction systems.
Maybe some kind of public nuisance law applies then? Akamai knows their place and doesn't tell me to go pound sand when I'm trying to read somebody's obituary. Incidentally:

legacy.com

Ray ID: 7f3e7bad3afbb731

That's the difference to me.
> because they handle VAT

Not everywhere unfortunately, so I still have to pay attention to it, which I can't so it's a show-stopper for me.
I spent a couple of days trying to migrate a react app at v17 bootstrapped with create-react-app to v18 and Vite, but eventually gave up because all the tooling and libraries and deployment processes needed attention along that migration path.

I'd be very surprised if 0.15 to 18.0 could be as seamless as you claim, for a real production application with hundreds of components and a few dozen dependencies
This particular drug is about post partum depression. Sleep deprived women, often functioning as milk machines, while experiencing major hormonal changes and possibly recovering from major abdominal surgery. These are not people “taking the easy route”. Save the bootstraps talk for other patients.
The problem with always trying to be first? If you trip and fall, you're screwed. While staying behind, you can just wait and not make the same mistakes as the people in front of you. Eventually, you'll be able to sprint ahead, but when you do, make it count.
Show HN: Social Bellow – AI-Powered Interactive Companion
Greetings HN,

My name is Edgar and I've created Social Bellow, an AI chat companion. Before this I spent close to a decade working on games with Grumpyface Studios, working closely with Cartoon Network as well as managing my own business.

I've built Social Bellow out of the need to manage prompts and eliminate the repetitive task of copying and pasting the same prompts. Storing prompts has the added advantage of providing Large Language Models (LLMs) with more context, thereby facilitating structured content responses. Moreover, I saw the necessity for a tool that could maintain the context window during conversations with the LLMs.

Social Bellow was built using AWS Amplify, NextJS, and the help of Vercel to do the streaming. Figma has also helped tremendously in the creation of the project. Having a workflow of Figma, Amplify Studio, and Git continuous deployment has cut down on the time to publish a change.

Social Bellow is free to use with OpenAI GPT-3.5 Turbo with a token allowance of 50,000 tokens a month. I've just launched this so you'd be one of the first to try it out.

Thank you for the feedback and helping improve the application!
Thunderbird 115 – Calendar is broken
> It also implies a booming, healthy economy where more people want.money to start businesses

Lol, have you ever been to Italy...? Banks will not lend to you unless you're quite rich already. Catholicism says debit bad, and the country is pretty conservative as a whole.

Italian banks making money implies two things: them screwing consumers (famously called literally "available cattle", il parco buoi, in local finance circles) and rich people getting richer.
I thought there were rules against using ChatGPT in comments here.

(For the uninitiated, this is a bunch of gibberish with a few science-y keywords for truthiness).
Website owners can just stop using cloudflare though…
Hmmm, interesting I use ctrl-space as my tmux prefix in WSL2 without issue.
From a user’s perspective I often think that applications which run multiple processes, demand multiple threads and large chunks of memory are too entitled.

I know it’s a (not even) half baked thought. But there’s something to that. We never really think of “how many resources is this application allowed to demand?”

Software would be orders of magnitudes faster if there was some standard, sensible way of giving applications fixed resource buckets.
Agree about the effects on health and the economy, but I think there's more to consider than that.

The health stuff isn't even so clear cut. Consider the psychological and social effects of mandating that people cover their faces. It's very valuable to be able to connect on the human level and to do so with a sense of freedom.
Long term the industry seems to be moving toward ammonia fuel.

https://spectra.mhi.com/how-ammonia-will-fuel-the-ships-of-a...
What bank are you using?
The "fab" in "semiconductor fab" is short for "fabrication plant".
We all build our own personal 'distro'. Yes, we may start from one of the 'big boys', but within hours or days, we start to build our own personal edifice.

We add in favorite apps, we add in favorite text-editors, or even GUI on-screen calculators that were not part of our 'base system installation'. After a little while, what I am using really bears no resemblance at all to the virginal LinuxMint distro that I started off with.

A 'representative version of Linux'? Hah! No such animal exists anywhere in the world.
Evidently we're not walking as much as we should be..
Disney explores cutting costs through AI use
> It took perseverance & researching install error messages to create an RPM that worked. So you might consider hiring for people willing to do that kind of work.

At its toughest, packaging is a long series of exchanges: one build error for another. It is a stubborn, patient, rabbithole diving, well-I'll-be-damned, yak-be-shorn kind of work.

> The good news is that I learned a tremendous amount[.] [...] Can’t recommend it enough!

And it's totally worth it, both for the packager and their users. :D
Plenty of worthy men died broke, and plenty of villains were fabulously wealthy.

Smart, hardworking, honest, kind men. There's a degree of luck and circumstance, there's the absence of capital, the time and place in which you live, the legal/social/regulatory environment, etc.

Then there are villains who work against your ability to compete.

They lobby so you can't open a competing barber shop without onerous licensing.

Nevermind ten billion dollar patent portfolios and old boys networks.

Fight the good fight, but nothing's guaranteed anywhere.
Imagine complaining about standardization.
UK half-heartedly tried with oil&gas, the companies largely found ways to avoid it.
Second market mover advantage, something Apple happens to be very very good at.
You sit down at a restaurant and open the menu. There are 100 entrées and they all seem fairly appealing, but you're not really even sure what they are made of. So you ask the waitress for a recommendation, and she rattles off 12 gourmet specials, and exactly the quality, origin, and preparation of all ingredients, and the special touch the chef puts on each one. When she is done, you're baffled; you stand up and take your date to McDonald's for a Big Mac and fries.
I mean he got pretty lucky I think, if I remember correctly he was able to get back the company "for free" from the VCs after they had written off their investment. He was then able to "bootstrap" it into profitability, based on the assets created through the VC money. Quite a good position to be in.
Clinton won 2016 in large part because of her overwhelming majorities in deeply red states which wasn’t that helpful during the elections.

Also because the Democratic primaries were objectively and transparently rigged.

IIRC wasn’t Sanders polling better against Trump than Clinton? Then again most conceivable candidates probably would have…
I just did a quick search and struggled to find anything about the performance issues you referred to - can you link something so I can take another look?
Thanks for the suggestions.