skysight-inc/HackerNews huggingface dataset:
There's no need for free samples in the UK[1], there's no direct marketing to patients, and yet we had to pass laws to stop marketing aimed at doctors.

Pharmaceutical companies were spending around £10,000 per GP per year. (About 40,000 GPs in UK * £10,000 == £400,000,000) Because of our PPRS that figure is probably one of the lowest in Europe.

The UK spends about £11billion per year on medication. Of that about £8billion is spent on branded medication. We have regulation schemes aimed at driving costs down.

The market and regulation of medication is baffling with many hidden effects. Here's some ridiculously in-depth information about the UK Pharmaceutical Price Regulation Scheme, and about regulation of meds in Europe.

(http://www.euro.who.int/__data/assets/pdf_file/0008/98432/E8...)

(http://www.oft.gov.uk/shared_oft/reports/comp_policy/oft885....)

[1] - because any medication is only £7.40 per item (per month) and only about 15% of people need to pay because of all the exemptions. Also, because of the pay structure of prescriptions there's a split between doctors (who write prescriptions) and pharmacists (who earn money for dispensing).
A master scraper sees with his mind, not with his eyes.
This kid may well have listened to PG to his peril.

Normally there is no advice he gives that is bad, but his "KILL HOLLYWOOD" and convoluted stance on copyright might make you think that reality is on your side. It is not.

This fantasy that all movies should be free on the internet is beyond retarded, it is actually hazardous to your freedom, if you try to profit from it.

Did he really think he was going to make a quarter million with no consequences?

Time to put away childish things.
Zynga plans secondary stock offering
No, because non-obviousness is judged according to the time in which the thing was invented. Was it non-obvious in 2000? If it was, its patent remains intact, even if it seem obvious now.

And I'll point out that novelty and non-obviousness are two different things in the context of patents. The majority of software patents seem to fail the latter the majority of the time. Novelty is more of a wash.
Apple is pretty much playing the game you play as a hardware manufacture. You pay for a lot of patents just to do business. A lot of Apple, Samsung, IBM, etc. patents are not these business process style patents. I'm not too happy about the business process-style stuff Apple or Amazon have, but I understand the rest.

This patent is about as business / software process as you get. It is just a consequence of solving a problem that would be solved the same way by anyone of with skills as a product of normal training in the field. Like "One Click" or "IsNot", it is really hard to understand why the rules were changed to allow this type of thing.
Dreamhost runs setuid, which means that any exploit can overwrite any of your files. Without looking at all of your files, merely installing a new version of wordpress doesn't remove the exploits that they have uploaded in the templates/, uploads/ and other directories.

Wordpress.com runs in WPMU mode with a limited sandbox, which makes those exploits difficult to insert.

Since you're running 3.3.1, and there is only one known remote exploit in the wild that was reported in early December that still remains unpatched, you're probably fairly safe. I would suspect more of your problem is remote exploits that have been installed over time that haven't been removed.

You'd probably be best finding a WordPress consultant to come in there for $50 and clean things up. Most hosting companies aren't equipped to handle securing sites when you're paying $10/month for hosting. There are dedicated WordPress hosting companies out there - including WordPress.com, but, short of keeping WordPress updated, I don't know if they proactively look for security issues.

Cloudflare claims to block these types of requests, but, from what I've witnessed, you need to start with a clean site.
Every startup should apply to an incubator
Startup Percolator: Free legal documents for startups from Perkins Coie
Game on in HTML5, but not so fast
Things worth being made would be prefunded, and things that aren't won't get made.

Because prefunding is effectively a requirement, there's no way for a creator to take a gamble, produce something with their own resources, and then try to make it up later. This is essentially the process by which all novelists get started now. Are you sure that prefunding is a suitable replacement?
...how in the hell does this terms of service surprise you? This is standard user-generated content TOS language, and Pinterest is a user-generated content company. Whenever did you think that you weren't responsible for what you post to Pinterest? Why would they assume the liability?
Think about this... Google charges you $900 to attend a conference that they will "teach you" how to build apps that work on their systems which benefit them way more than you.

I know Apple charges a developer fee as well.

Amazing how this hacker/developer world works - pay for access to their app stores, pay for conferences to learn how to make apps for their app stores, etc.
The reality is Apple filed lawsuit on company that actually invented Mobile Phone (Motorola) about a silly design patent.

Facebook didn't invent anything.

In reality Apple should be the real bad guy in whole patent issue.
You really don't care as much when its got mains power but not all of these devices are plugged in. You will see them a lot in simple hand held consumer electronics like garage door openers, remote controllers, wireless mouses, kitchen timers and so on. In battery powered devices saving a mA make a world of difference.
That's generally not a model that results in decreased costs, not to mention that we're in a situation now and for the forseeable future where people really need to stop thinking of the government as a free money fountain. We already can't fund our current commitments, adding yet more billions onto the already huge pile is not necessarily a good idea.

(And don't even think of trying to sell me on it being a net money saver. It won't be after the special interest groups are done with it.)
Turbines kill fewer birds than coal plant smokestacks. Newer, bigger ones move more slowly, killing fewer birds as well as being quieter. They also produce more power per area.

As for the view... well, you can't please everyone.
free for a year
Maybe she needs an HTC Rhyme phone, with its dongle^Wcharm thingy:

https://www.google.com/search?tbm=isch&hl=en&source=...

Its a dongle^Wcharm thingy that plugs into the phone and acts as visible alert for phone state while its buried in a purse. Pretty funny toy.
It's a combination of the scientific challenges in finding a new drug and the safety hurdles that the FDA puts up. Most of that 10 years is taken up by the clinical trials that the FDA requires.

I guess you could say it's the price of having access to thoroughly tested drugs that are both safe and efficacious.
Trolling, nothing to see here. Move along.
> So that's it?

not really. he gets to appeal.

> If a judge believes it, then it must be true!

who else do you expect to enforce laws? the better question is, do you know anything about british law? why do you think your interpretation of british copyright law is better than the judge's?

> He's not even a proper judge!

i'm not sure what you mean by this.
This was extremely interesting to read. The guy has not been officially verified though.
the link I posted is about Hittail, that is surely not a "content" site but a service
War-time Software Building
This is really cool and will be useful for a niche, let's not make it out to be something else. A watch is a piece of fashion first. His assessment as pretty nerdy is correct - this isn't for the main stream user to parade around.

"Hey I made this hat that can send text messages if you just think about it!" "But I'm still wearing that ugly hat"
What I wrote about pauses is about pauses as opposed to ums and ahs. The unstated assumption is that the rest of the package (message structure, body language and so on, as per PG's speech) is in sync.

While Bush is indeed a really good example of how not to do it, his failing was not pausing. His failing was, as you say, confusion and incompetence.

See my post below.
So if you don't doubt the timing is a coincidence, that would mean you think it is a coincidence?
All I said was try a placebo and see if it works as part of the standard routine. Obviously with a potentially fatal illness you want to use everything in your disposal to stop it. Why would you not use your last resort for something that serious? But then that includes using both physical and psychological treatments. If someone has HIV then the boost that positive thinking delivers to the immune system (http://legacy.lclark.edu/dept/chron/positives03.html) combined with anti-virals could save a life. If it's something like, say, depression or migraines or the flu, then a placebo may well cure it and there's no need to prescribe drugs which have nasty side effects or are addictive. If you can get something for free, why would you not do it?
I'm no fan of patent lawsuits, but Apple had lawsuits ongoing with Microsoft when Jobs arrived and agreed to settle them in exchange for Microsoft making a sizeable investment in Apple. The rest is history, and no one seems to look back upon that in distaste.

The difference? Tech news cycles, including blogs and online papers, now report news 24/7 just like CNN/Fox, etc, and are pretty relentless.

Personally I don't understand why any of those patents were issued in the first place, and perhaps a start for reform would be to get people who have some experience working in the industry into the patent office.
What about the obvious, Windows servers / VPSs, that would have RDP enabled?
Is OK if hate them both?

But seriously, the thing is that the phone market has never been "free" in the sense that the web has been free. Since to become a carrier you have always needed a significant capital investment in hardware, the model of also needing to pay patent-rent for your software has been just a piece of this. But creating a website has been the freest possible activity - even having your own server only involve nominal expenses and nominal control relative to becoming a phone carrier.

Further, the web is currently the closest thing to a free press that exists today. Anything to exerts control over this is doubly compared to the certainly objectionable activity of extracting patent-rent from a given industry.

I think this argument shows Yahoo is at least as bad in its action as Apple here (even though I actually have been Yahoo-sympathetic and Apple-hostile up till now). Censoring the App Store is an abusive, monopolistic practice but it still left the web, anything that puts breaks on the web itself is maximally terrible (that terribleness greater-than-or-equal to other problems so I'll still accept the answer "they're all bad").
And I'm not arguing about expensive end-of-life care. I don't have a strong opinion about end-of-life care. There could be a lot of value in changing the way we finance end-of-life care. That doesn't change the fundamental problems we have with health insurance now: either it chains you to your current employer, or threatens you with an intolerable risk of bankruptcy.
A lot of ISV's use RDP to access client machines. Most, but sadly not all, clients place serious limits on the RDP (IP of vendor only, VPN). The problem here is that RPD authentication is not required to deliver the payload and who knows if your vendor's security will avoid an infection on their end.

A really nasty attack could target small to medium ISV's with a lot of clients and use those machines to jump past firewalls.
Advertising is all about manipulating people. Furthermore successful advertising is all about making the perceived voluntary cost to the user smaller than the perceived value to the advertiser. If you took Facebook's revenue and divided it by the number of users, I'm guessing they would lose a lot of customers by charging that amount as a subscription fee.

If you don't advertise, you need to charge money.

If you charge money, and a competitor launches with successful advertising, then you will go out of business since the perceived cost for their users is lower than what you need to charge to stay in business.
Cassini spies wave rattling jet stream on Jupiter
Does anyone have a mirror of the PDF? Their servers appear to be on fire.
this amount includes the gadgets that they give to people. last year there were three if i remember correctly. one was for game devs only.
Some ISVs "require" direct RDP and won't use VPN. This should be an automatic no-buy, but sometimes the powers-that-be forget to ask the system administrator.
Apple is suing over dumb gimmicky UI patents such as slide to unlock.
I understand the need for patents although I really really dislike them and what they're doing on a grand scale. In the case where a small company makes a discovery but doesn't have the resources to develop the product as fast as larger companies would, I definitely see the need for a patent system. The patent basically stops others from 'stealing' their idea.

But what if the patents were limited to 1-2 years and after that it would be public domain? That way the initial inventor would gain the advantage of a head start (and 1-2 years is huge by todays standards) and only hindering global development by a year or two.
I felt like the ending was cut short and the Anonymous bit was a bit sudden. Still a good read.
I know of at least one college management system that "requires" this.
I find it funny that the author suggests people read it on their Kindle when PDFs render so unreadable there.
Why There Will Never Be One Social Network to Rule Them All
yep, not my favorite as I said, but there are others in their portfolio that are more "solid".
Here in Brazil, one of the major mobile carriers makes Yahoo the default search engine for Android phones. Go figure...
Show HN: PHP Fog's Command Line Interface
So did you read the linked PDF?
>Yes human lives are at stake (but then they always are), yes our models should follow reality as closely as we can if they are to give any useful predictions.

I would argue that our models do not follow reality closely enough given that there are people who cannot afford to have their lives saved. If our model yields such results then it ought to be rebuilt or refactored.

>But what do you mean the business is backwards? Surely they are trying to make money.

As in peoples' business, what they do. To rephrase, the business of how we handle healthcare research is backwards. The part of society responsible for that should not be in the mindset of making money but that of saving lives.
There is one more twist about that. Copyright supporters like to call it property - but they sell it as a license to consumers.
Screw the headset, put a speaker in your palm. Add in a camera, NFC, etc. and move the display to the other side, we have a smart glove.
To Boost Windows Azure, Microsoft Launches Company’s First Startup Accelerator
I can't make sense of the post; with the same reasoning, we should hope for the murder of a well-known celebrity so that we get better murder legislation.
Combining mobile and desktop apps in one
The new APIs in OS X for apps wanting to use the App Store seem to borrow a lot of ideas from iOS. An idea came to me yesterday: is Apple trying to blend the two OSs? If a user tries to use the desktop version of the app or connects an iPad to a monitor, the desktop version of the application is displayed allowing for "real work" to be done with a touch interface or even physical mouse/keyboard. Otherwise, on the go, either the simpler iPad or iPhone version of the app would be rendered, depending on the device.

It's a pretty simple idea, and I feel like I can't be the only one to think of it. But, I can see it working out much better than the "two-in-one" approach Windows 8 is taking.
Active Resource removed from Rails
People are also so upset with Apple.
The Post-Steve Jobs Decline of Apple's Genius Design Theory
Thx for correction.

Google reveals that Y! did sue X-fire apparently over a buddy list patent in 2005 which would also make the same point though.
Oops. In the above I said the system shouldn't pause ever. This is silly of course. What I meant to say is that it shouldn't pause except when hit with hard resource limits. Loading from the disk or performing an expensive calculation will take some time of course. But there shouldn't be random pauses when interacting with something that ought to be fit into memory. Modern systems are full of pre-emption, GC pauses and other non-determinisms.
I also like to put it this way: software companies like to patent the application of well known tools and processes to be used for a specific problem domain.

My favorite example is glue. Everyone knows what glue is. However, has anyone used glue to hold itemX and itemY together? No? Patent!
Unique Identifier Is Dead, Long Live Unique Identifier
http://en.wikipedia.org/wiki/Gyrobus
RSS also includes shared memory pages (those that are currently resident).
I wrote a Python script for my Nokia N900 that vibrated the text of a SMS in Morse code. It was an interesting idea but only lasted a day as I don't know More code well at all.
I haven't seen stats recently, but I know that as recently as a year or two ago, Yahoo had much more penetration internationally (ie, not US) than Google did. I'm not sure if that still holds, or if it applies to Brazil, but that may be part of it.
Adjusting term limits on patents (downward) certainly makes sense in the tech industry, though 2 years feels short to me. It probably makes sense to look at how long it took various successful companies to get established, and set the time limit to that kind of time scale. That way, if I have an invention that I want to build a company around, I have a reasonable period of time to get it off of the ground before I have copycats on my back. Their ramp-up time will be much shorter, as I will have taught them how to make the thing that I've built my business on.
Why are there so many of these debates?

This is really starting to be like php vs. ruby vs. dot net discussions. The end result is it doesn't matter as long as you're comfortable starting and finishing a project with it.

The value Bootstrap brings is to save time. Also, no one really should care what developers think of this as the teams race towards finishing their MVP. Your job is to finish the MVP - that's it!

IF YOUR PAYING CUSTOMERS are bitching at you for making yet another Bootstrap site, then let's come back and debate this. You guys are all focusing on the wrong problem.
I'm quite serious. Compare the donations and budgets for campaign donations against institutions like, off the top of my head, the Methuselah Foundation and the SENS Foundation, Alcor and other cryonics institutes, and the Singularity Institute. Of course, people get worked up over pretty frivolous things, so maybe I am hugely underestimating the outcry. Maybe if Facebook went offline, the response might cause the US or other governments to nationalize social networking, mandate registration and monitor all communication, and provide custom-binary-format data dumps every so often on request all in the name of keeping your scrap-booking memories in tact.
Right you had to be very careful when writing an app in Visual J++ as it always ended up using Microsoft UI libraries only available on the Microsoft JVM.
It's somewhat surprising how little controlled antibiotics for non-human use are. I can't buy tetracycline for myself without a prescription, but I can buy tetracycline labeled for fish-aquarium use from Amazon, despite it being the same chemical (survivalists and hypochondriacs have long taken advantage of that loophole). And of course farmers use it by the ton.
How is this reinventing unix, at all?
While more powerful, atop is rather confusing. htop is friendly.
HN's pro-Apple bias. The "slide to unlock" patent is just as bad as anything Yahoo is doing.
This already happens, both at the energy generation level (power companies broker energy futures (excess supply/demand) between each other - see Enron for more) and at the energy consumer level (big businesses like refineries and foundries and the like pay less for electricity pulled in off-peak hours).
Raspberry Pi retailers clarify shipping costs on $35 Linux computer
This is one reason why I have never and will never file any patents for my current company, even though there would be some financial benefit for me doing so. Even though the company is very benign and has the best of intentions with patents, one never knows what could happen in the next 20 years and who those patents might be sold to.
For some reason this didn't work for me - it would simply not load the twitter page. Cool idea though!
Critical windows bug makes worm-meat of millions of high-value machines
I stumbled across this project today and was blown away by how highly polished the user experience is compared to the http://www.graphviz.org/ project.
Startup Sauna’s catch of the season so far - new startups from New Europe
Oh, I interpreted A/C as Active Current; my mistake. Thanks for pointing that out.

(I, for one, don't mind pedantry :))
There's the Sony LiveView (http://www.sonymobile.com/global-en/products/accessories/liv...), which looks more feature-rich than the InPulse.
Google's Focus On Beating Facebook Is Wrecking The Company, Says This Former Engineer. Google's Focus On Beating Apple will seal the company's fate. Google's Motorola acquisition is going to be a disaster for Google.
Thanks PyCon --OpDemand
5 Lessons in Fear for Female CEOs
Not mentioned much in the article: this is far more important in the context of aging than for genetic mitochondrial disease. See:

http://www.fightaging.org/archives/2012/03/a-general-method-...

"A therapy that can robustly correct any mitochondrial DNA mutation throughout the body can be turned into a way to rejuvenate the stochastic damage of aging that occurs to the thirteen important mitochondrial genes not replicated in the cell nucleus. If asked to wager, based on the evidence I'd suggest that mitochondrial damage is the largest individual contribution to aging, which is why it's important to see progress on fixing it or making it irrelevant. So this, I think, is a development worth watching."

Though I believe the RNA-correction methodologies imply some form of continuing therapy to patch the damage versus the SENS approach (allotopic expression and porting back the gene products to the mitochondria) that is a one-time thing:

http://sens.org/sens-research/research-themes/mitosens
but why is it so bad that the new CEO (I dont see that it matters he is new on the job) of any company whether Yahoo! or Xahoo! is going after another multi-billion company that he believes is infringe and making money off of someone's else invention?

I asked that 3 times and got nothing other than downvotes...
Wal-Mart Tries Hollywood Cloud-Seeding Plan to Sell Films