skysight-inc/HackerNews huggingface dataset:
Killing cancer is very similar to killing weeds in agriculture, it's full of ̶r̶a̶n̶d̶o̶m̶ ̶m̶u̶t̶a̶t̶i̶o̶n̶ biodiversity that give it all sorts of potential. People get mutated cells all the time in their lifetime, but those cells get cleaned up because those cells don't have the proper mutations or circumstances to hide from the immune system.

It's rare enough to find a way kill an organism but leave a related one safe, like trying to target millet in tall fescue grown for seed, or targeting mites on honeybees. Usually it's actually just a small difference in tolerance between the two that you are exploiting. We are trying to kill a human within a human.

So what happens is that even if you wipe out 99.999% of the problem, it means the remaining portion of the pest had a genetic mutation that gave it increased resistance. So that's what will reproduce and you can't just increase the rate and try again. You are now just trying to stunt growth.

This is why cancer can be reduced below detection limits, only to have it re-emerge several months or years later and kill the patient because the treatment no longer could touch it. Monotherapies should never be utilized, because failure will eventually occur. Failure in agriculture only means herbicide resistant annual ryegrass or kochia, eventual economic damages, and regulation mandating cycling of modes of action. But Failure in cancer treatment means death and a family burdened by massive debt.

It should be noted that "cancer survival rates" are defined as the percent of people who survive a disease such as cancer *for a specified amount of time*. And I've noticed that the rates that get thrown around tend to range from a several months to just a few years. If a doctor manages to keep you alive and suffering for 2 years and a day before the cancer kills you, your "treatment success" gets added to X survival % (over two years)

I definitely welcome more tools to utilize, but there should always be some form of multi-therapy, a magic pill is a dangerous hope that doesn't understand the enemy.

Incidentally, look up Hyperthermia Therapy, it's less well known but pretty neat. It takes advantage that cancer cells aren't as robust to survive denaturing to begin with due to generally being in a low oxygen/blood environment (which limits detection by the immune system), but also that they are forced to either die or reopen their previously closed membrane transport systems which will now release chemical signals that the immune system can see as a problem. It's usually combined with chemicals that prime the immune system for "alertness". While this method isn't immune to resistance, it's able to exploit the very thing that the cancer needed to hide and survive.
This is a pretty good one

https://github.com/arcanericky/totp
Quite possibly with SMS as the fallback option in case the soft token is lost.
Looks much more like a thickness planer than a can opener to me.

Yo, does that go any lower? I need another quarter inch off that truck.
Cloud would be a huge profit maker as YouTube, search, ads would all then pay cloud for hosting. And they’d have no where else to go.
Despite having a single dedicated key on my keyboard that opens speedcrunch, I will always reach for my trusty Casio calculator that I bought 20 years ago in school.
The other day, about a third of top posts on hn where about this. I got the impression there was an organised campaign by the believers. The usual healthy skepticism was buried beneath the cheerleaders. Most top comments where along the lines "I never believed it. Until now".
reference: https://www.youtube.com/watch?v=_FBQetJqAwk
The way ContentID is put to use may be the best interpretation of copyright. You get to reuse someone's work and the original author gets paid. There are some false flags reported with it but it's hard to say how many are due to actual violations (when you legally license a song from me but you didn't know I illegally sampled Taylor Swift and so you go complain about YouTube when your video is demonitized). I heard the bigger issue is false DMCA takedowns by shady companies who don't participate in Content ID...
With my conspiracy theory hat on, perhaps the authors were encouraged/coerced to not release proper documentation to reproduce the recipe entirely by [their bosses, state agencies etc.]
If the claims are true, then the implications to defense, weaponry and such are very high, and the C|N|D* agencies like to not lose their cards in the game..
/conspiracy

Or

Real science is just darned difficult, and the scientists are working hard to reproduce the results themselves. Which is more likely.
CodeRabbit: AI-Powered Code Reviews
It's a matter of priority - you can get by fine without using keigo, and instead of learning all the weird intricacies of keigo you could go learn something more practical for day-to-day use first (even native Japanese speakers complain about keigo, e.g. use of manual keigo). Teineigo is perfectly sufficient in everyday use.

To put it another way, it's a bit like trying to to learn about how to write in the style of a judicial opinion when you're still learning how to talk to someone at the bar.
Use Nginx as an API Gateway
getiin' old, it's the second time today I miss the obvious, clearly visible, information :-(
Confusing the equivalence of -50% and +50% is very common. In fact, many video games provide wrong bonuses based on this misunderstanding (Age of Empires 2 being a famous example).

Even a simple calculation will show the truth:

-40% = 0.6

+50% = 1.5

0.6 * 1.5 = 0.9

Conclusion: With every coin-toss you lose 10% of wealth on average.
Take a look at Bitcoin
I have mapped F8 on my keyboard to launch a terminal with IPython open
This won't help anyone who requires Wine as part of their workflow, I luckily don't, but I understand that Wine should be on target to handle Wayland by the next release early 2024.

This will give it proper HiDPI support and Vulkan rendering to help speed things up.
Interestingly random events like this do tend to cluster. There are lots of arrangements where clusters exist and very few where it doesn't, so clustering is a lower entropy state. Plane crashes are similar.

https://en.m.wikipedia.org/wiki/Poisson_clumping

https://stats.stackexchange.com/questions/109390/how-odd-is-...
Global PC shipments declined 13.4% year over year
That’s not how I remembered it. Chrome really was a good browser and I would argue is still a good browser (for now).

IE got displaced by Firefox’s predecessors because MS got caught napping - they disbanded the IE team thinking they have won. Firefox simply got outcompeted by Chrome as Google went crazy making it faster and faster. Firefox fell behind often enough that Chrome managed to take almost all of its market share.

I’m not happily with Chrome’s dominance, and Google’s abuse of its market position, but it was a good product for most of its life span.
Yeah I really want to see my past text to see if it transcribed it correctly but can't with the current box size (web)
We all here live in a tech bubble. None of my friends and family have a 2FA app, or know what one is. They understand SMS, and it's better than no 2FA at all.
Is “to fly elk” a slang phrase I’ve never heard or just some weird autocorrect?

[Edit] Either way, I’m gonna use it from now as a synonym for “tell [someone]”. Thank you for the inspiration!
The blob is the low-level wireless firmware, and regulatory rules make it obligatory. When you use the ESP32 as a dumb modem in conjunction with a separate MCU, you‘re still running the blob. You have gained nothing.
Two words: "Scrum Master"
Not this one, which has a very detailed description of the synthesis, including what has worked and what has failed.
The more intersting thing is - why not have the queries run on the car as aggregator/filters and only send query meta data home? Why does it have to be rawall?
Holdout sounds like it is explicitly added to ward off any criticisms insinuating DRM.

If a server is not denying access for clients with no valid attestation then what exactly are the servers gaining from implementing WEI?

CAPTCHAs also reasonably prove that the user is a human and legitimate but not all captcha challenges are solveable by humans in one go.

Businesses have denied access for those failures and they just repeat the challenge until the captcha is solved successfully. If the failures are less per client they can easily be treated as tradeoff against security.

What's stopping websites from doing the same with WEI? They can always deny access and repeatedly request attestation until a positive reply comes.

This is acceptable for those "attested" clients where the failures are random and within an upper bound. But a client without attestation can always be denied or they can be shown different limited content altogether.

In both the cases the unapproved clients are at a disadvantage.
Apple is absolutely a premium brand, but they're not a luxury brand. The key distinction is that a luxury brand revels in real or perceived exclusivity; with prices set for the primary purpose of gatekeeping the brand to a select audience.

While not cheap, Apple products are obtainable and utterly mainstream. In fact in the rare instances where Apple has experimented with luxury it has been a dismal failure — Apple Watch Edition being a noteworthy example.
This may seem like a good idea but so much of Google's power comes from the Search + Search Ads monopoly. That is where they are anticompetitive to the max, that is where a change needs to happen. Splitting everything else off doesn't solve the core problem.

Within Search + Search Ads you have a platform where Google are/have:

- the sole vendor of a digital asset - ads

- the sole marketplace for that asset

- a closed algorithmic trading system with no public auditing

- no public ledger or auditing showing who bid what

- currently one of the main customers for those ads (advertising their own products)

Along with that you as an advertiser have to install tracking on your site allowing Google to see every transaction, all revenue, every customer, of your business. The level of spying on the advertisers is insane, when seen in combination with the closed source algorithm and market for the ads the potential for manipulation is enormous.

The whole ads platform is built for extracting every last cent of margin from advertisers businesses. It's anticompetitive, monopolistic, and to some extent even a protection racket.

The most important "breakup" needs to be the ads business from everything else, including search. That's going to hurt, and I don't have the answers to how to make it work, but changes are needed.

I suspect a "breakup" isn't on the cards, maybe some strong regulation of online ad marketplaces, ring fencing them from the rest of the business and auditing of the platform?
This is great! Is there some non-lethal way to retrieve the initial system settings to diff from?
You don't really need all that stuff. Sanitization is straight
forward to implement and only required for user generated strings (since you want to make it HTML-safe). It could be argued that automatically sanitizing everything including already safe data types like numbers and system-generated content adds an unnecessary performance overhead for certain projects.

As for events, binding is really very easy to do and it's already localised to the component so managing them is trivial.

Loops are also trivial; you can simply use Array.prototype.map function to return a bunch of strings which you can incorporate directly into the main component's template string. In any case, you can always use the native document.createElement and appendChild functions to create elements within the component and add them to its DOM or shadow DOM.

I've built some complex apps with plain HTMLElement as a base class for all my components and found is much simpler than React without any unexpected weirdness and using fewer abstract technical concepts. Code was much more readable and maintainable. I didn't even need a bundler thanks to modern async and defer attributes of script tags among others.

I think the reason why people are using React still is just marketing, hype and inertia. The job market which is gatekept by non-technical recruiters demands React. It's all non-tech people making the big decisions based on buzzwords that they don't understand.
Well, my impression was that it's a revolutionary hot technology that only recent browsers support. Something like the browser doing the "SSR" natively on the fly before rendering the page DOM.

Anyway like I mentioned, I didn't get the chance to play with it and understand its purpose. Misconception -> higher expectations -> disappointment.
No it's much simpler than that. You either confirm the transaction on your phone with pin or FaceID, without the card involved. Or if the amount is too high (50k+ at my bank) or you don't have your phone, you use a small device provided by the bank.

The device reads your card, asks for the pin and then spits out a 2FA code to enter on the website or app. The old ones only did this code thing (usually with SMS as a backup way to get the code, but most banks have moved away from sms now). Some more advanced ones have a digital signing capability by taking a photo from a QR-like code on the computer screen and then displaying the signing code for you to enter.

These advanced ones are a bit out of use now that everyone uses the mobile app, except for business accounts and larger amounts like my bank's 50k limit on mobile app confirmation. But I don't regularly transfer more than 50k in one transaction anyway.

Edit: Here is a picture of one that we use with a large Dutch bank for our business account with the QR-code reading thing: https://4.bp.blogspot.com/-6c1NGHew1P8/VBqvTeqDQdI/AAAAAAAAf...
I think the current phone system is a legacy from another time. I dont know what the replacement should be but I think the following would be MVP requirements:

Only the owner of a phone number can present it as the calling number, so if you receive a call or message you can be guaranteed (within reason) that its from the owner of the number.

Overcharged numbers must not exist, if billing is needed it must be over another channel. Or at a minimum require specific optin pr number between the caller and their carrier (not the carrier where the number is terminated).

Personally I also think that anonymous calls should not be allowed, I think they should always be required to show the phone number that is calling you.
Well maybe from search engines, who'd pay to be the default search option? So far, it mostly worked for Mozilla.
> ~~adblock~~ origin

FTFY:

uBlock Origin
Thankfully, there is an apt definition for evil nowadays: Google.
Huh. So I wrote the code, and ran the simulation. Now I get it.

Investors: 100,000 Iterations: 100

Average worth after 100 iterations: $83.923

Average net worth increases. However the distribution of wealth is skewed
dramatically.

Winners: 13,704 (net worth of more than $1 at the end)
Investors worth < $0.01: 53,935

What That Guy was worth (the investor who made the most money):

$1,171,830.00

He flipped 71 heads and 29 tails.

Median wealth of all investors: $0.00515378

What could have been made more clear in the presentation.
Average wealth increases; but average log(wealth) decreases.
Investors on the long improbable upper tail make
huge amounts of money; investors on the lower tail
just don't make much difference to the average, when they
lose 40% of $0.01. What causes the wild income distribution:
the fact that log(wealth) decreases on average. This doesn't
decrease the total money supply, but it does increase the
skewed distribution of wealth.

It has nothing whatsoever to do with anything related to flipping consecutive heads and tails. And a great deal to do with the fact that the log(gain) is 0.405465 and the log loss is -0.510826. So the average investors log(wealth) decreases over time even though the average total wealth increases.

Most figures are wildly variable from trial to trial. Most especially, what That Guy makes is highly variable. If he rolls 72 heads and 28 tails instead of 71 heads and 29 tails, then he's worth $2,565,000 more, and single-handedly adds $25.65 to the average net worth! The number of people who lose money is surprisingly, depressingly consistent.

The obvious conclusion: increasing wealth concentration is an unavoidable consequence of capitalism that probably has very little to do with merit.

The only solution: eat the rich.
Money for developing chrome is not an issue. Google search could pay chrome to be the primary search engine just like they pay mozilla. Microsoft could fund chromium based on their use in Edge. Etc…
How did we go from door handles to needing safety regulations to reveal the secret exit button? Why did the car need to feel like an escape room in first place?

I'll never understand some of these decisions... like granted the car looks sleek, but it's so hard to use day to day
> It was so obvious the whole German uranium set up was on a ludicrously small scale. Here was the central group of laboratories, and all it amounted to was a little cave, a wing of a small textile factory, a few rooms in an old brewery. To be sure, the laboratories were well equipped, but compared to what we were doing in the United States it was still small-time stuff

Thank God the Germans didn't realize the potential there or the world would have looked very differently now. It's not as if they didn't have the technical chops to make something like this work. They even had working jet fighters.

Sometimes I wonder if Heisenberg secretly took them on the scenic route. Because his whole uranium cubes on strings thing looks a bit contrived.
Mom and dad were architect and engineer in the transitioning period to CAD software and still remember my days spent sharpening drafting pencils by hand on Stadler sand paper holders. Koh-i-noor is another brand I remember.
Mozilla makes money with Firefox. Brave does with brave. It is not impossible that Chrome could. ChromeOS, default search engine, integrated VPN offering, ... The browser has a monopoly market share, income would be huge fast.
Further, selling GCP to AWS is not how we "break down monopolies".
> But Failure in cancer treatment means death and a family burdened by massive debt.

The latter is, among developed countries, only true in the US.
This is really cool. I can practice reading, listening and writing on my own. I wanted to practice speaking German.

I learned a few languages just through speaking with natives.
That's a known issue; there are a number of companies in YC that have had to pay thousands of dollars to Twilio.

The way I've worked around this issue is by:

- Verifying the phone number before sending SMS.
- Using a whitelist of supported countries.
- Limit the amount Twilio can charge us

Hope that helps
duplicate of https://news.ycombinator.com/item?id=36981580
> Nothing seems to have been designed to naturally fit together, everything feels like its glued on

This is a trademark of Windows since the beginning.
Ah this again. No offense to you, but yes, the obnoxious anonymous Russian troll who's only proof is a photo of a spec of dust (glued?) in a syringe, who refuses to take a video, who says she didnt follow the paper beause she immediately invented a better way to make a different room temp superconductor, who says she doesnt care about superconductors and who keeps tweeting bizzare USSR propaganda?

I wonder why she's not included in the Wikipedia article. /s
> Meta has no real interesting in delivering anything other than a product they can ship to millions of people on day 1 at a low price point

Ahm, are we forgetting the QuestPro? Meta tried to build their "Apple headset", 5x the price of a Quest2 and loaded with all the R&D features they could find. And it was a colossal flop. The whole thing is getting shutdown little over six months after release.

They forgot to include critical features like a depth sensor, they couldn't figure out what to do with the eye tracking in their software, face tracking wasn't a feature anybody wanted and reduced the battery dramatically when actually used, passthough cameras are a blurry mess, resolution is too low to work as actual desktop replacement, etc.

The whole thing, despite 5x the price, was firmly stuck at just being a slightly better Quest2. Meta spend the last seven years building a portable Oculus Rift, and they succeeded at that, but despite billions in R&D they haven't really managed to advanced VR beyond that point.
Thanks, I'll keep this in mind. This this apply to actual opinions one would hold?
Let me get this straight: you are selling a guarantee of maximum price for a medical service?

You are selling health insurance.
Incandescent light bulbs are officially banned in the U.S.
Not that it makes any kind of difference for a tiny personal homepage, but I recently added just that on mine: https://github.com/kiliankoe/kilian.io/blob/master/index.htm...
>"multipolar world"

Its more of a polite way of saying a great deal of the rest of the world does not want to live in a unipolar world run by the USA and its allies.

So, not quite the dialectic that one would suppose. Russia is but one party to that ideology - there are many, many more, and thats what makes it multipolar.
> To name and shame: BNP in France. My personal account stayed on the app, but for my company account, it I only get SMS now.

I remember a story about a university in Lithuania also opting for either SMS or a proprietary 2FA app, but not allowing TOTP either: https://fsfe.org/news/2023/news-20230418-01.html

What's worse, all they had to do was enable a checkbox in the settings somewhere but they went on an embarrassingly long e-mail thread back and forth, not even willing to help the users.

So I think that in cases like that, it's definitely a good idea to call attention to the issue and tell more people about open technologies like that! Unfortunately, most people just won't care.

That said, TOTP is actually decent and I'm surprised that it's not supported everywhere, especially given how much shouting about SMS not being secure enough goes around.
China Doesn’t Want a Geoengineering Disaster(Feb 2023)
Great walk-through on the production challenges, but this thread is very precise in its description of the superconducting mechanisms in LK-99. I haven’t followed recent developments but is there any kind of consensus to support that this is the underlying mechanism?

The thread comes off as a pitch for a startup, hence my skepticism.
Wow, great point! I had ran my simulation several times to check that it was reasonably stable and it gave me less than $1 average wealth each time, so I thought that was that. But just now I re-ran it with a much larger population and indeed the average wealth grows now instead of shrinking. Sadly I can't edit my comment above any more, but:

> that the expected value of 1 iteration can be positive while the expected value of repeated iteration can be negative is very fascinating!

is indeed untrue. Thanks!
It’s worse than this sadly, at least in Ventura.

I previously gave access to an app to access removable storage (because there was no more granular way to just give the app access for a single folder - which is a serious freaking defect if anyone from Apple is reading this - that’s just plain bad), did some editing, then revoked the access.

The problem is the access wasn’t revoked and it could still access the whole drive. Checked the settings pane - definitely no access to removable drives (and no full disk access), went back to app and it could still access.

Went through tcc on the command line and it showed that the access was revoked but still it persisted reboots.

In the end I had to completely reset the machine and start from scratch just to revoke that drive access.

macOS really needs another Snow Leopard “no new features” release.
That doesn't sound like a typical corporate thought process. There is plenty of cognitive dissonance around logos and mottos and whatnot by corporations, and unless it affects the bottom line, they won't do anything about it.