skysight-inc/HackerNews huggingface dataset:
I agree with your description of reality. That doesn't mean that we have to accept it or say it's ok. It may be politically infeasible for the suggested policy (allowing people to choose treatments even if some people _will_ choose unwisely), or, if enacted, it may be impossible to keep it. But I will continue to advocate for it anyways. I believe in and advocate for _many_ policies that I have close to zero hope will ever be enacted.
If this interests you, I'd recommend the ACOUP blog articles by Bret Devereaux on this subject.

https://acoup.blog/category/collections/this-isnt-sparta/

Audio format

https://m.youtube.com/playlist?list=PLcIwe3bxds8ZvX9wL0Vf2hz...
Then we are in agreement that the Pfizer CEO acted fully correctly and you shouldn't take this video as any evidence he hasn't taken the vaccine yet?
What do you mean by “screwed up”?
Indeed, there's the perverse insensitive to create a repeat customer.

Funnily, an insurance company would push against that, for a final cure. They would like to avoid to pay for repeat treatments.

But the medical insurance in the US is more of a payment scheme, and apparently is not interested in paying less. I bet there is some regulatory loophole, or a government guarantee, that makes it more profitable.
What other wedge issues would you say don't fall under 'improvement of quality of life'?
You can log the user out by changing the “realm” parameter, which is a freeform string and can be quite long. As well, setting realm will cause devtools to use cached credentials similar to a new tab.

“No themed login form” oh no! Anyway. (I really think that the “theming” on login and sign-up forms breaches which bits are done by the browser and which bits are not. We’ve had to kludge back support)
Same question regarding the "pro" moniker. Also, why did he commit pre-built binaries to git?
Yeah.

It should be legal too. I'm not defending the use of it in any way, this is not about drugs but a more fundamental problem: governments deciding what you can and cannot put into your own body.

They should inform people about potential dangers and effects of substances, and try to prevent the underlying reasons for people to, say, do heroin or fentanyl.

But if someone wants to do it anyway, making it illegal just makes things worse as people will be stigmatized socially where they should be welcome/accepted the most, and they'll obtain the substance illegally and dangerously (who-knows-what-it's-laced-with and exact actual dosage) anyway.

So just inform and support the people but make it legal and relatively safer to consume for harm reduction.

But if someone wants to OD and kill themselves, I mean, it's sad but it's their own body and their own life.
That is an interesting and relevant point, but it does not apply in case of Jake and others like him -- he has no alternative where he might live.

In my opinion, the FDA ought to be more open to allowing experiments in cases where it is clear the patient is aware of the untested nature of the treatment.

It would result in tragic cases like the three you describe. During COVID-19 it would have resulted in people taking Ivermectin which was ineffective and even harmful.

But during COVID-19 it would also have resulted in determining 6 or more months earlier that the vaccines we made were safe and effective and the number of lives saved in that single instance would have greatly outnumbered the losses from 100 years of experiments.
Most vaccines only require 1-3 injections.

This example is poorly chosen for a different reason explained in my comment.

Alternatively, we can look at novel curative intent therapies for cancer like focal ablation or stereotactic radiation.

The recurring customer alternative of chemo/immunotherapy or the conventional surgical option are at least an order of magnitude more expensive.

You won’t find much novel systemic therapy that’s curative intent because it’s really hard (?impossible) to do, not because the system wants to make more money slowly killing patients.
China regularly uses the Great Cannon (the offensive DDoS capabilities of the Great Firewall) against GitHub because it hosts free VPN software mainland Chinese can use to work around censorship. So whether they want it or not, they are involved already.
What's actually happening to the plastic? It can't be coming off my clothes in the washing machine at any profound rate, yet remain good as new for years. If I dispose of something in my locale, it goes to a sanitary landfill and will never see air, water, or sunlight.

I'm oblivious to fashion, much less fast fashion ;-)

Is there an ecologically responsible way to use synthetic clothing? Natural materials are not without their environmental impact either.
Rambling maybe but works fine at 1.5 speed. No, I liked the video because they feel the (graduate school application) Personal Statement (PS) should be abolished but explain how the application file works and what that PS allows the applicant to do. And how it's a shame not to make effective use of it. Solid way to look at the process.
Seemingly so. On the one hand I'm into wishful thinking, on the other, cynical me says 'if they bother to so act at all'. implying SFA good will come out of it.

History bears this out, take the Russian Revolution/uprising of 1905 and the authoritarian crackdown, it erupted again in 1917 and was successful that time but quickly went pear-shaped a few years later and fell back into totalitarianism. That lasted until 1991 when there was a minor reprieve. Now it's pear-shaped again—totalitarianism again reigns supreme.

No wonder it's so difficult to shake off one's pessimism.
> Doesn't seem like you're actually disagreeing then, if systems design can apply just as well to a 'monolith' and it's often the better design.

"Can" and "do" are two different words.

"Monolith" is often a cop out to hide amorphous big-ball-of-mud projects. In fact, the luddite-like movement's aversion to system design is rooted in the fact that it's not necessary, and their irrational aversion to microservices and distributed systems and systems design lies in the fact that, unlike monoliths, they are far less tolerant of hacking together big balls of mud and demand instead some degree of discipline to design a system and comply with the system design.
If buying, selling, and possessing are all illegal, it's illegal for all practical purposes.
Laptops are actually kind of ok just not how people use them. ;)

Elevate & decoupled! Raise the screen. Use a Bluetooth keyboard. Stop staring down!

Ideally one can rig up a way to get the keyboard under the laptop. That's rough though, not always easy (some soda cans & cardboard... Where there's a will!). Often I end up with my laptop on my adventure pack and the keyboard in front (or on my lap). I used to just use tablet style 2-in-1's, which rock: the Tryone gooseneck arm (or many others) let's you hover the screen in really nice position, wherever you want.

I was pretty fine having a decently hidpi 11-12 inch screen positioned close in, but I have really wanted a bigger 2-in-1 I could work with. I miss 2013 when there was the bigger bigger bigger push for tablets: we are creeping back up, but the bold 18.4 beasts of that age were I hope only a bit too soon.

It all comea down to!:

> Improve your coding environment
~5 years ago I had desktop Linux and a chrome book. All compilation happened via cloud build and the preferred IDE was the cloud-based web app. I didn't really use my desktop for anything, not even ssh.

I switched to a Chromebook in the pandemic and honestly it was fine. My workflow barely changed. I wasn't a vim fanatic at the time so I didn't really care.
I solve this problem with a time check coupled with an atomic test-and-set of a global variable.

If the global is less than the timer, use the timer value and set the global to it.

If the global is greater than or equal to the timer, increment it and use that value.
If that is the reason, perhaps temporarily moving to another state might help? The author appears to still be mobile.
Everything you said has absolutely nothing to do with what GP said.
The first gay pub I dared set foot in now has a rainbow plaque. Why that matters
generally, insurance companies do require efficacy. many of them have decided not to cover aducanumab for that very reason. though this also gives insurance an additional excuse to deny stratospherically-expensive gene therapies and other life-saving new treatments, since even the most effective new drugs won't have e.g. 10 year survival rates until they're a decade old.

agreed on advertising though.
It helps underline the hypocrisy of the current moral norms.
I use reader view all the time! - I just activate it manually. I don't know of any such whitelist in Firefox, though, and there's no Safari on Linux.
I never liked the seated, sedentary nature of programming. Over time though, I've forced myself to take regular breaks, say every 10 minutes to straighten out my spine, and every 60 mins I go for a longish walk to clear my head and repair my back. Any hard problems or puzzles I encountered usually get solved when walking, as my brain is in a different state and can problem-solve better.

There are ergonomic items you can buy for a home-lab situation or maybe the office splurged out on Herman Miller chairs, but no amount of ergonomic items (Vertical Mouse etc) will solve the sitting down problem. You have to do pattern interrupts and frequent (reparative) breaks.

This is known to increase productivity. If you're in your twenties you can probably get away with long sessions sitting down without major issues, but over time, sitting /will/ affect you if you're not doing interrupts and exercising/repairing yourself.
I've been using ChatGPT on my Android phone's web browser for quite a while now.
> I began to see a career in business as an appealing alternative to the personal sacrifices, hypercompetitiveness, and arbitrary hiring decisions I would encounter in academia

What a sweet kid.
What would the internet of people look like now?
Agreed. The regulations are beyond ridiculous and definitely not for the greater good of the society, only to clear the names of bureaucrats and regulators.
Keen to here whether anyone here uses a exercise/sitting ball at a desk as a way to improve posture?
Auto-Inflating Scooter Helmet
Several years ago French company Bumpair invented an inflatable helmet. They partnered with a scooter share company in France, and offered this wild feature: When you unlock one of their scooters, you hit a button on the app and the helmet auto-inflates!
I had to draw a line so I could actually release something. But Windows and Linux support is definitely a target. In fact, the core software was originally developed on both macOS and Linux with PC/SC smart cards (both PIV and OpenPGP) and Vault as key stores, but without any GUI components--everything compiled into a set of PKCS#11 (for OpenSSH, OpenSSL ENGINE, etc) and PC/SC modules (for GnuPG). And I stayed away from macOS and Linux APIs as much as possible to ease a Windows port.

But friends and coworkers I explained and showed the idea to didn't get it conceptually (e.g. people have the idea of key rotation drilled into their head as if that's the alternative to HSMs, instead of it being a mitigation for a fundamentally broken key management ecosystem), plus most people just wanted something they could point SSH_AUTH_SOCK at, so there needed to be a daemon/menubar/taskbar service. Ultimately the hard part was modeling and building a GUI around the concept, so it would be easier to understand and use. To get something out the door I targeted my daily desktop environment, macOS. It's using Yue as the GUI toolkit, which supports Linux/Gtk, macOS, and Windows.

I took a year off of work to finally get the idea out of my head, which I had been mulling over for many years. But now I find myself in the middle of a downturn in the software engineering job market (anybody hiring or interested in investing?), so while I have work in progress to round out the macOS app features, Linux and Windows (which is really where the commercial viability exists, I think), will need to wait until I have some cashflow.

I'd like to eventually release the Linux work as open source. But FWIW if someone has a specific use case in mind and is willing to fund development, I could very quickly build and release a [non-GUI] Linux package. PKCS#11 and PC/SC Linux modules still build in the tree, and adding a TPM key store adapter along side the other internal adapters would be relatively simple. In fact, a Linux PKCS#11 module for accessing Vault Transit Engine keys with TPM 2.0 mTLS authentication would be maybe 1-2 weeks of effort; slightly less if just straight TPM 2.0 support. Most of the implementation is already there, but polishing and testing something which can be supported long-term takes some effort.
I love the innovative thinking here but I can easily think of a way to game this system. Snake Oil LLC mounts a PR campaign claiming the governmen is trying to shut them down by delaying approvals so they can't get their money so they can't undercut Big Pharma. If Snake Oil (TM) doesn't work, why have patients ponied up $X billion in fees over the years?

You have enough stories like this (plus there will inevitably be some mistakes by the FDA that will be shown to be proof of government perfidy) and the conspiracy theories will have a field day and fuel a black market.
The academic world (nothing to do with the public sector) has its own performance metrics. It also follows it rigidly and in a more cut-throat manner, because there is less jobs.

The criticism is that the performance metrics are often in opposition or irrelevant to the stated mission(s) of said academic institutions.
There's a lot of problems with it, though. Even if advancing medical research was the main goal-- ad hoc use in dying patients provides unclear data. Medical research wants clear inclusion criteria, metrics, reduced statistical noise from similar patients, predeclared outcome measures, and economies of scale in running trials.

We already let terminal patients participate in medical research, but only inviting patients at times and meeting criteria that optimizes the research. Also, only where IRBs have found it to be ethical-- this means not replacing a drug with proven benefit with an experimental treatment with unknown benefit recklessly.

But terminally-ill patients push for inclusion beyond this: to be dosed when there is not an active trial, or to be dosed when they are so sick that the outcome would be difficult to interpret or compare, etc. This isn't for medical research, this is for self-preservation.
"Consistent with TSA's long-term roadmap, CLEAR has been collaborating with DHS and TSA since 2020 to implement new industry-wide digital identity standards.

The implementation of these new standards will digitally transmit a passenger's identifying information

from CLEAR to next-generation TSA hardware at airport checkpoints and avoid any need for passengers to show their IDs," per a Clear spokesperson.
There's school of thought that pixels are point samples of a waveform (separately along horizontal and vertical axis, and that separation is useful for performance). In such interpretation resizing is downsampling that removes higher frequencies. You can then reason about this mathematically and show that you have an optimal filter, which preserves as many frequencies as possible, without bias or aliasing.

In practice, it's a bit more complicated, because pixels can form a square wave without Gibb's phenomenon. Physically they're not points. And there are all kinds of biological factors in perception.

As for reference to neural networks, I'm not sure. They're used for superresolution (upscaling), but I haven't seen them used for downscaling. They could be in theory.
The requirement to test for efficacy and not just safety was only added in response to Thalidomide (which disaster had nothing to do with testing for efficacy). So what you're asking for is very not radical.
> ... it also has a clean declarative reading of the language recognized -- ie, A | B and B | A recognise the same language
This seems bad. Help me understand.

In what ways does always letting individuals choose to take an experimental drug not work, if we make sure they know what is known and what is not? They are desperate, and that's a horrible place from where to make a decision, but dying is a really bad alternative.

What are the pitfalls that would allow for this to not always be the option? How would this go more horribly wrong than just letting these people die?
And a way to respond to that demand would be a allow one extra (that) post doc to interview. A trade off to humor that professor while keeping the good candidates around.
apple will declare war on the uk
Comcast? I have att fiber and I can pull down 5-10tb/mo no problem.
This reminds me of a quote from James Mickens regarding computer security.

"Unfortunately, large swaths of the security community are
fixated on avant garde horrors such as the fact that, during
solar eclipses, pacemakers can be remotely controlled with a
garage door opener and a Pringles can. It’s definitely unfor-
tunate that Pringles cans are the gateway to an obscure set
of Sith-like powers that can be used against the 0.002% of
the population that has both a pacemaker and bitter enemies
in the electronics hobbyist community. However, if someone
is motivated enough to kill you by focusing electromagnetic
energy through a Pringles can, you probably did something to
deserve that. I am not saying that I want you dead, but I am
saying that you may have to die so that researchers who study
per-photon HMACs for pacemaker transmitters can instead
work on making it easier for people to generate good passwords."

My point being if someone's motivated enough to break into your house to steal your passwords in order to steal your life savings, that's probably an outside scenario, given most B&Es are junkies looking to score enough for their next high.
> This should be banned

And who would enforce it in international waters?
I'm very interested in hearing about how the process went for you. I added my email address to my HN profile, let me know when you get it so I can proceed to remove it.

I'm not sure that good news will come out of my meeting with CHOP doctors but I'm going anyway.
But at the end of the day, failed treatments still kill people. Some may choose the experimental treatment, and die, over the crappy chemo, which gives them a chance to live. Escrow won’t bring them back.
There's a lot of paid plugins that throw a new interface on it but no, base redmine doesn't have a click and drag kanban. It does have all kinds of project management integrated with git tickets, I thought the gantt chart was perfectly good tho.
Why America stopped building public pools
When there is nothing beyond death, there is no death. We won’t be sitting on the sidelines blindfolded. We won’t exist. From our perspective the death never actually happens.

I’m surprisingly okay with my lack of experience of the billions of years before the earth existed, and I won’t experience the billions after.

That said, just because we can’t stay at Disneyland forever, we might as well go on the rides while we are here.

We are all dying. Some sooner than others. As a student of philosophy, this perspective has driven me to avoid the common status concerns that many people chase.
Oh I think it might be to do with the capitalization. We will add a fix. Thanks for bringing this up
Bret Devereaux is the author of the submitted article.
I was just about to say this reads like a Bret Devereaux article...and it is.
> basically, its mostly bull.

I don't think your link says what you think it says.

Linus Tech Tips: used crypto graphics cards can be a good deal.

You: Linus said it's mostly bulk that these cards are counterfeit.
For heaven's sake, think a little. This is an empirical discussion of hiring heuristics that result in a certain system. It's not just networking (generally used to refer to development of professional connections, though yes people use it to refer to smoking weed together or engaging in the same sport) and the poster didn't say nepotism either. It is certainly favoritism (hiring people you already know and like without necessarily casting a wider net) and it's clear that there are structural effects from it that develop on gender and race lines (you're in the men's hockey team together, you're in a fraternity or sorority, you're in an ethnic club).

What sriram_sun said is entirely factual, and a lot of us get left out of the networks for various reasons. That's also just factual. The fact that folks here are all "oh you're just jealous, you're calling it nepotism" -- nah, it's just facts, and there is no need to get emotional about it. There is nothing inherently wrong about hiring people you know -- like any move in a game, it has knock-on effects. If you'd like to help broaden networks, just do it. And for those who feel defensive about it, consider the phrase "hit dogs holler".
Don't forget your hands! You don't think of programmers as "people who work with their hands", but we really are. (So are surgeons, by the way.)

I typed too hard for a few decades because I began on some really stiff keyboards. That has not been good for my fingers. You shouldn't hit keys harder than you need to, because if you multiply that by a few decades the impacts on your joints and tendons add up to damage. If your fingers hurt after a day of coding, pay attention.

Wrist angle matters. Carpal tunnel is no fun. (So far, I have been spared that.) Pay attention to strain on your wrists as you type. If there is some, think about your geometry, and how you can change it.

One of the things I despise about laptops is that their keyboards are too small for my hands. For serious work, I need a full-sized keyboard.

So when you think about ergonomics, don't forget your hands.

(And don't forget your eyes. Look away from the monitor to something at least 20 feet away, for at least 20 seconds, regularly. I forget what the recommendation is - every 20 minutes, or every 2 hours, or something. But regularly.)
Did you never experience the situation where someone you care about is making a choice you think is wrong, and you want to protect them from themselves?

I'm not saying this is the right thing to do. I'm just trying to explain how it happens. People don't make good risk judgements in general, and other people think that it is good to do good by force. This is why seat belts are mandatory, smoking is discouraged, drugs are illegal, public companies traded on exchanges are strongly regulated, and so on and so forth.

> Yes probably more people will die

You really don't understand why we choose the option where less people die? We value life, I guess.
None of that has anything to do with the proposal you're replying to, which is about the efficacy requirement, not safety.
https://www2.math.upenn.edu/~kazdan/425S11/Drum-Gordon-Webb.... is a great paper on hearing the shape of a drum

Life at Low Reynolds Number makes you think of things which arent visible but move :https://www.damtp.cam.ac.uk/user/gold/pdfs/purcell.pdf

There are more but lets see if the above two work for you first
One day we will be able to test political ideas in a realistic simulator. Then we will have the ability inform citizens of the effects of what they are being told.

When that happens, they will realize that the low merit ideas of authors such as this guy are useless.

The decline of Sparta was due to the greed of the elite, who became self-serving at the expense of the rest. Not because of the merit of Spartan soldiers.
Without socializing of medical costs I completely agree. But if you are asking other people to pay for a part of the consequences of your decisions then you should accept that those other people can constrain the decisions you can make.