skysight-inc/HackerNews huggingface dataset:
Wall Street dinged them because Gilead is a one trick pony and the street overestimated revenue, not because Gilead cured HCV rather than just treating it.

Additionally, if their drug didn’t work as well they wouldn’t have gotten away with charging 100k for a course and wouldn’t have made 40B+ in revenue.
As a professor who served on a hiring committee this past year in a top-15 engineering department in the US (and not in CS), some of this did not really ring as true to me. Overall, I came away more pleasantly surprised by our process than how I might have assumed it to be as a PhD student (where I assumed it was entirely based on favoritism). Based on the intersection of publication record, research statement and topic areas we were recruiting for this cycle (which was clearly advertised in our position), there were really only about 20-25 applications which were plausibly competitive.

We ended up doing a standardized set of Zoom interviews for about 15 of them - here too, many candidates were simply unable to clearly explain their past work and make a clear pitch for their vision and work (even with slides). This is an essential skill for running a lab and one any prospective candidate should practice and refine! From that point on the whole department was involved and, at least for us, everyone had an equal say and felt safe speaking up. ~4-5 were invited for on-campus interviews and one candidate was liked the most by nearly everyone, leading to a consensus.

As a public university, there are a lot of things we do in a standardized way, and sets of personal questions etc. we do not ask. Is it fair? I'll leave others to judge, as selecting one person to hire out of ~200 applicants is not an easy task. But I don't think it was capricious either. At our department, we intend for everyone who comes as an assistant prof to be tenured, so it is very much a long-term hire and commitment we are making. We take that job seriously.
According to the original post, the economy not working out for rural syrians was a thing back then. Look at China, they put up with the CCP because the economy continues to do well for most. Communists have a strategy where they appease/convert the rural working class first and then cities natually fall, they do that knowing cities only function because rural people let them.
Anecdotal. When "quack" * science helped.

After COVID (both the disease and the vaxx), I got heart arrhythmia, I had around 5000 irregular heart beats a day (PVCs and PACs mainly), and those all happen in a matter of hours, so when they happen, it's pretty debilitating.

After a while, I invested in a Bluetooth stethoscope and ECG watches, the doctors finally believed I have something. However, the cardiologist's advice was to learn to live with it, because it's completely harmless and in young people, ablation, beta blockers are not worth the risk.

Having these irregular heart beats is a very uncomfortable feeling, so I was looking for articles about the root causes and potential treatments.

After trying a couple of things (both pills and lifestyle changes), I found an article that says arginine and taurine reduced the number of irregular heart beats in their experiment. I tried it out and I have basically 20-50 irregular heart beats a day. When I stop taking them, the irregular heart beats come back.

Now, I know I'm doing something that is potentially risky, but to me it is worth it (and I reduced my dosage, and I try to quit using them every couple of months).

* it's not really quack science as the science is real, just that me applying it in my situation was not recommended by a doctor
I thought the recent New Yorker article on FDA's drug approval policies, "When Dying Patients Want Unproven Drugs", was balanced, insightful, and well-written. It covers Thalidomide, and focuses on ALS and HIV. https://archive.is/u6vmI
Doesn’t really add anything to the conversation though
Declaring something to be a contradiction because you don't like the conclusion they came to is not the most compelling argument.
Most big tech firms give engineers RSUs for this reason
It does feel like checked exceptions. But the subtle but important thing is that results are not control flow constructs. They're just values with syntax sugar, so all other language features work with them (you can store, modify, nest, pass them without try/catch/throw constructs)
Traitors who fought their country for slavery weren't heroes. The Founding Fathers were
I also have a medical condition that has caused degenerative arthritis in the lower back. I find that if I'm seated in anything but an Aeron I can't remain seated for long. I suspect it's less the brand than the mesh with some give. However, since I know the brand, I happily spent the $1300 for my home setup. (I also sprung for an Uplift standing desk)
No, it's the other way around.

Towns and cities are actually far more resource efficient than rural and suburban sprawl.

The only inefficient thing in them is highrises. But five-story buildings are incredibly infrastructure-efficient. Walking through a midrise neighborhood puts you past more people per minute, than driving 120 mph through a suburb.
In my head, the volumes would be standalone, specific to a particular topic, backend, frontend, cloud, devops, etc. So it would be one book at a time, not all at once.

No, I haven't written anything this large. Hence asking before committing to it. Once book (volume) may take a year or more I'm guessing.
A direct reference to program closures in relation to 'abstract object languages' can be found on page 92 of Landin (1965)[1].

1: https://dl.acm.org/doi/pdf/10.1145/363744.363749
True. But speeding up the search for a treatment saves many future people.

The ethical tradeoff between definitely saving a life now or probably saving many lives later is an age old problem, but one which society hasn't properly converted into laws and processes in medicine.
That's a feature, not a bug. I don't want to lose all of my passwords if I have to reset my Google password.
> allude to it without explicitly mentioning OO by name

Right, that's the point; they were talking about classes and objects; the term "inheritance" was not yet used ("prefix" instead), neither the term "object-oriented"; it was a completely new paradigm and the terminology had first to be developed. Kay in his 1993 paper claims that he called his approach, as manifested in Smalltalk-72, "object-oriented". So I would expect publications to use the term after 1972. As I said I found it in Ingall's 1978 (written end of 1977) paper.

Concerning your reference 3 (Lisp) the term "object" is apparently used to refer to atomic symbols; Lisp entered the OO age with Flavors, CommonLoops and CLOS in the eighties.
Domain matches content I guess
Even successful people have a success rate below 100%, and the more things you try the more failures you will accrue. For any successful person that has ever lived you can cherrypick all their failures and write an article like this.

The only person that doesn't fail is the person that never tries anything. Being successful is not about never failing.

This article completely ignores the Battle of Thermopylae which is probably one of the things Spartans are the most known for. In that sense, the author himself failed to portray Spartans fairly, making him a failed historian.

In 100 years this historian will be completely forgotten.
That second link seems to have some issues with credibility.

And if you think Antivirus Software selling users' browser data is a poopy thing to do, you should take a look at what Cell Phone Carriers do with your phone's data.
First and foremost, I really appreciate the project, so thank you for your help with it!

Documentation is honestly probably one of, if not the most difficult part of development. Even if the programming problem you’re solving is immensely difficult, how do you then simplify that in such a way that it is accessible to a wide range of backgrounds? I’ve heard that writing code is hard, but reading code is harder—and documentation is essentially writing about reading code, so I wouldn’t beat yourself up about it.

The merge feature is immensely helpful, and I’ve found that writing internally focused documentation really does help with adoption. As in, “here at XYZ we are using this tool in these cases—here is how and when you would use each of them. Here’s a link to more contextual documentation”. Even if people don’t actively seek out the documentation, it’s still a hell of a time saver to point the tenth person asking how or why to do something to a static copy of what would essentially be the response.
I'm way more at risk of locking myself out than someone getting onto my system, getting into my password store, exporting secrets, and using them to ruin my life. Honestly it would probably make national news if someone physically burgled their digital identity.
I suspect they are talking about the statues glorifying the confederate slave owning society.
Might be to avoid a visual reflow - otherwise the content will render, then the webfont will load and the whole page will reflow and jump around.

Google amp used to have a ridiculous 4 second timeout waiting for the font
Can you explain why it is not the case everything happens at random? Why these particles seem to follow physical laws?

What does random mean? Are you asking why the universe appears to be consistent and intelligible at all? Where would we be if it weren’t?

The weak anthropic principle covers this nicely. Perhaps it is an unsatisfying answer, but scientists and mathematicians aren’t usually in the business of answering ontological questions.

Maybe a good place to start thinking about this problem would be to read Wigner's work "The Unreasonable Effectiveness of Mathematics in the Natural Sciences".

I have studied all of this. Wigner’s account is very important for the debates it inspired but it’s far from the last word on the topic. There have been numerous replies addressing all of Wigner’s claims. Try reading Hamming’s replies to start.
Climate change could cause a home insurance meltdown
With $250B in cash (or whatever it is right now), they could raise a hell of an Army.
Now there’s a thought. Clever.

Does it make sense to also keep some decoy items, like an old MacBook in plain sight?
> While most new drugs indeed fail (the large majority of them), in diseases with very poor prognosis like OP's cancer, I think we would benefit from still looking at the tradeoff as a decision under uncertainty, instead of a complete unknown. Even with less data than we would otherwise want.

Which is literally what just happened with osimertinib for NSCLC. It was approved for clinical use and was implemented without any overall survival data.

Safe for clinical trial means the harms are considered safe, has little to no relevance for efficacy.

Once again you’re ignoring the fact that there are (almost) always alternative treatments that have been proven to prolong life.

No one is offering nothing to poor prognosis patients.

From the blog post:

> Monday I’m starting chemotherapy, but that’s almost certainly going to fail, because a CT scan shows four to six new gross tumors, four in my neck and two, possibly, in my lungs.

In someone with such an aggressive disease everything is almost certainly going to fail, experimental or not. Chemotherapy will buy some time. Who knows what an mRNA treatment will do but there’s certainly no (not little, no) evidence that it will be curative.
Coil (especially John Balance) were perfectionists. In interviews, they stressed the importance of continuous experimentation but also noted that they needed to impose extremely high standards and ruthlessly discard much of their output when it didn't make the cut (which was the majority of the time).

I remember reading an interview by Balance where he described their work as a modern take on the alchemical process of constant refinement. As far as album covers go, Love's Secret Domain [1] is a personal favorite.

It is a shame that this documentary doesn't include Christopherson.

[1] https://www.sorrystaterecords.com/cdn/shop/products/coil_0e4...
Extremely convenient the end was determined during the race.
Exactly! Some people on here have weird ideas.
Customizing software does not trigger a license violation, distribution does. If it is an internal tool there is no distribution, and there is no license violation.

As a corollary redmine is written in ruby, I don't think it is possible to distribute it without the source code anyway.
Presumably there are limits in place via podman (cgroups)... I didn't test them but did feel the urge to do so.

I also didn't test network access, which could cause arbitrary code execution.
> The next best thing is to use the laptop docked but closed

That's what I do, combined with a 64-thread/128GB build machine.

In fact, I'm so happy with my discontinued HP UltraSlim docks mounted vertically on the side of my desk/divider that I went to IT and special-ordered the last model that fit those docks. My new laptop is five years old. Worth it! :)
No idea why this is posted here makes a ton of sense for the elderly, have seen some malls open early for walking groups.
At least SV compensates well. Sure you get laid off in 3 years but the gravy train was pretty good in the meantime.

Hollywood, not so much if you're not an A list actor.
2FA protects two different attacks: 1) Hacker obtaining your password (through phishing, compromise of third party, etc.) 2) _You_ actually being compromised yourself somehow.

It is still effective for the first protection if you store your codes in your password manager, but less for the second. I say less, and not completely, because if your machine is compromised, gaining access to your phone too is only a matter of time. Of course this can be mitigated why proper hardware tokens, but most people aren't using those.
“Please read my rant about how this useless hair-shirt I wear to clear first party cookies too often breaks the web (for me)”

> the web has no notion of a “device”, and this is a very intentional design choice made for privacy purposes [...] why do web developers persist in believing in this fiction of a “device”?

Cookies are a core part of the web which enable the construction of stateful applications on top of a stateless protocol. “Remembered device” is usually just an extra cookie set on login, or a row in a backend database. It’s no more fictional than the web itself, which is after all just a series of electrical impulses over wires.

Whether a device (however you build that abstraction) has previously logged in is a high-signal data point that meaningfully increases account security at login time and all serious web security teams use it to protect their users.
particles follow particular mathematical laws

We don’t know that they do. We assume they do, but our laws are not their laws.

You’re like the person who sees a birdwatcher recording their observations and asking “why do birds exist?” You’re asking the wrong question to the wrong person and demanding satisfaction.
>When that happens, they will realize that the low merit ideas of authors such as this guy are useless.

Which ideas are you specifically talking about?

>The decline of Sparta was due to the greed of the elite, who became self-serving at the expense of the rest. Not because of the merit of Spartan soldiers.

Did you even read the article? Spartan soldiers were the elite. One major reason why Sparta declined was that this severely limited the size of armies they could field. And, as the article argues (supported with lots of hard historical facts), their military merit was, overall, rather mediocre.
> USound’s latest speakers are 5 millimeters long and 1.4 millimeters wide—or about the size of an asterisk in a printed book.
In 2021?
Yes, I suppose it could be taken that way. I wasn't intending to argue one way or the other, merely to point out that such an apparently simple condition ("if someone understands...") actually encompasses a huge amount of uncertainty, and so doesn't necessarily represent the "easy answer" that it might at first appear.
Basic yoga moves are fantastic for this.

Sun salutations with downward and upward dog. They also strengthen your core.

There are more moves in the Ashtanga sequence, whenever I do it I get a feeling of my discs being stretched and exercised like a rubber ball.
Mental health doesn't have to be done in the most stupid way possible. And yet could be much more present, available, temporary.

An institutional system can be built with cross-checks, inspections, corruption fighting mechanisms, etc. By this I mean actual, independent, not powerless, not perfunctory, corruption-fighting, enforceable, etc. As opposed to the usual such cross-checks around here. This is a far broader issue that just mental health but simply (not) doing mental health on the street isn't a great solution.
I agree. This would’ve likely saved me a lot of time that was spent on trial and error but now it’s not new. But this is great reference to forward to new folks getting started.
My friends mom bought a fancy light for 2000€ that was supposed to cure her cancer. Spoiler: it did not.

Now, that wasn't in the US, and I'm pretty sure the quack device wasn't approved as a medical device. But the fact is that fraudsters will sell their fake medical products to desperate patients who have nothing left to try. These people should rot in jail.
India Bans Rice Exports
two questions:

- where do you go, and why?

- how do you get your US insurance to cover/work with providers outside the US? does it just automatically work or…?
> Adulation of the Spartans is less about historical exactitude and more about creating a model that everyone can look to in order to build esprit de corps.

Very good, but why does it have to be a brutal -- for the standards of the time -- slave state that wasn't even particularly good at war?

The current situation in Ukraine should be proof enough that the myth of manly men doing manly things does not produce armies that are actually effective. Almost everything Sparta fanfiction does is actively counterproductive.
OptaPlanner was forked as Timefold by the team behind it:
https://timefold.ai/blog/2023/optaplanner-fork/
We made it twice as fast (by replacing Drools).
Passkeys?
Yes, a small percentage went to paying interest on loans, and some of the money spent was borrowed. And the majority of spending from income tax still went to the things I mentioned prior.

I'm not sure I'm following what you're implying.
I guess the FDA has a role in minimizing the market for snake oil.
>There's a lot of problems with it, though. [...] Medical research wants clear inclusion criteria, [...] , but only inviting patients at times and meeting criteria that optimizes the research [...] But terminally-ill patients push for inclusion beyond this: to be dosed when there is not an active trial, [...]

Your objections are sensible but that's beyond the scope of this author's argument. I'm just taking author's following comment at face value:
">The FDA was loathe to approve initial mRNA human trials, even when those trials would have been full of people like me: those who are facing death sentences anyway."

If it's the drug researchers who don't want the author as a test subject, that's understandable. But he's arguing the _FDA_ shouldn't be the one blocking his participation.

For the situations where there's "no active trial" caused by the FDA not greenlighting the experiments, then of course, the complaint will be that "terminally ill patients want to participate in trials that don't exist". That's sort of a circular argument -- caused by the FDA.

Again, if there's no active trial because the medical researchers themselves are not yet ready, that's understandable. But if the drug scientists are ready but the FDA is not, that's a different issue and it's the focus of the author's essay.

All that said, I don't know how much scientific progress the FDA holds back because of "safety". I'm just trying to explain the author's position.
1) your argument is right
2) but it hasn't been an average of every 7 years in at least 30 years.

It's 13.2 years. And perhaps it shouldn't be. There's lots of foregone opportunities when you stick in a home and don't move to better employment.
The UK has a long tradition of reusing outdated institutions. If the only thing you know about the House of Lords is its name, you'll be very surprised about who's in it and what they do.
How I became a machine learning practitioner (2019)
This is an important thing to be aware of, but this is not unique to Elixir, and the article title does not mention Elixir specifically although the example shown is in Elixir. If you are not careful about your dependency chain, attacks like this could happen in any language. When you pull code in and run it in your app, you are trusting it as if you wrote it yourself.
It's not that they are delusional, it's that they can't prove it. They don't have evidence, they have faith.
All though you're correct it is rational to not fear death. I personally, and likely many other people here, have a very very strong aversion to it.

I DO NOT want the cessation of experience.

Ideally, I'd like to continue in perpetuity, to see the sun rise from Venus, or visit my tenth generation offspring on Saturn.

All of those missed experiences would be deeply saddening. To see our species conquer to universe, to see intelligent life bloom in the darkness of space, that is the goal.
Yandex hits me with captchas every search and every 2-3 pages on Firefox.
I tried using this last year or the year before. Ended up using DeepChem instead https://github.com/deepchem/deepchem.

That said, I’ve found RDKit to be the singularly most useful toolkit in this area.
Exactly, a treatment should be free until approved by FDA.

The team would try to make the treatment an experiment useful for science. They would have no incentives to kill prematurely patients that would otherwise have lived longer. They would work in good faith.

Disclaimer: I actually had had a treatment (surgery) not yet approved, it saved my foot from amputation. This was in Europe.

The doctor was adding me to the long lists of patients he saved. He also trained other doctors to perform the surgery. Eventually the procedure was approved by FDA and in Europe. I'm glad to have contributed.

Before going on that I read all the articles related to my problem (many thanks to sci-hub) and then send a email to the surgeon. He said "I can indeed help you" (best day of my life) I didn't pay anything (only the plane tickets to get where he was)
If I knew I were going to die, I'd at least want to try something new even if the chances were slim. If it didn't work out, at least it'd be a new data point for those that come after. That means something.
When the American Revolution erupted, society in the Colonies was split pretty evenly between those who rebelled and those who wanted to remain under England. The American Founding Fathers are representative of a side that ultimately won by doing things like burning down many loyalists’ homes, or tar-and-feathering them, and then exiling them to Canada or the West Indies, in order to cow the other loyalists into keeping quiet. Sure, that is a bit less heinous than fighting to perpetuate race-based chattel slavery. But there is no reason to view the American Founding Fathers as heroes unless you are of that small portion of the world’s population that has been through American schools and still has an attachment to the mythology presented in civics classes there.
Same problem as a national VAT: turning the tax base into an ATM empowers myopic polixy.
Could you expand more on your view about the current situation in Ukraine?
We've also done some initial experiments, and seen no improvements in productivity, and the comments from the people using it were rather negative.

Maybe it's sector dependent? Maybe systems programming doesn't have enough reference materials for them to learn from?

Certainly not the "Clearly obvious difference" some people seem to be claiming to see in some places online.