skysight-inc/HackerNews huggingface dataset:
Just "invest more"?

Who does the investing? Not "The Market". The incentive isn't to cure but to treat. The Market wants (repeat) customers.

The government? At least, in the US, we've been dismantling the government's ability to do this since at least Reagan. Even our so-called Liberals aren't pushing hard here. You'd have to look to the "fringe" Progressives within the Democratic Party to even come close.

And why? Because "fuck you, I've got mine" may as well be the national motto of the USA at this point.

People will bristle at this, certainly. Look at Biden: he's done so much!

Biden is no FDR. We need a real social safety net in this country. And, yes, we need a "right to try", even if it means waiving malpractice rights in those cases.
At the time it was assumed that other DOS licensees would be building their own architecture. There were several kinds of "DOS-compatible" computers, most notably the PC-98[0], which had MS-DOS and Windows ports but no IBM compatibility whatsoever.

Several other companies would then try to clone the IBM PC; they all got shut down for copying the BIOS code. The PC clone market only kicked off once Compaq was able to write a legally distinct BIOS.

Another part of the reason why Microsoft was able to sell IBM a nonexclusive license boils down to their existing business relationship. Microsoft was just their BASIC vendor and they sold BASIC to everyone. IBM wanted CP/M-86, but Digital Research was taking too long to ship it. Seattle Computer Products[1] was also making 8086-based computers but had no OS for them, so they wrote their own - QDOS. Microsoft was willing to buy QDOS and port it to the PC for IBM, which fixed IBM's biggest problem with the PC, so why wouldn't they take the license?

In order for IBM to object to taking a nonexclusive DOS license, they'd have to both realize that the clone market was going to be huge, and that the IBM PC BIOS would not be enough protection against clones. Both of which were not at all certain when the IBM PC was under development. Remember, the whole point of the IBM PC was to put together something quickly because they were playing catch-up to Apple and Commodore, not to build a computing empire like IBM's enterprise business.

[0] The machine Touhou started on. Also the machine so difficult to do animated graphics on that most developers made pornographic visual novels instead. Like to the point that the Japanese market would just assume PC games were porn.

[1] A subsidiary of the SCP Foundation
The Ideal platform is essentially an agreement between banks to process payments from a trusted, third party processor, who collects fees from the seller.

What I just described is also what Visa and Mastercard are.

While the graphic might be nice marketing for Ideal, I wouldn't categorize it as separate from debit/credit card.
Just because this is my wheelhouse and I’ve been in it a long time I’m going to get pedantic.

An STB and OTT box are different - different video delivery mechanisms of IP vs. QAM.

This line got blurred however in the early to mid 2000s with IP based services.

The hard part of getting a box deployed outside of the Motorola and Scientific Atlantic boxes that ruled the early days of cable was a lack of standards of back office systems. So you couldn’t just build a box you had to have a whole stack for device provisioning etc.

I worked for a company Comcast bought in the early 2000s when they were buying up smaller regional systems and it was a mess trying to get everything aligned. It probably took 15 to 20 years until they finally ironed it all out. To be fair to Comcast they did a good enough job that they now license their X1 platform to other operators (Cox, Shaw, Quebecor)
I call it Pontius Pilate's Ethics.

It is (a very rational) approach for administrative workers, who get little credit for getting things better, but are at risk when they can be taken accountable for something terrible.

That way, for example, in Germany, there was a halt on the Astra-Zeneca vaccine after a few cases of thrombosis per million. For comparison, it is one in six for COVID. The halt, most likely, caused many deaths. Yet, these deaths "have happened". If there were a death because an administrative organ didn't take action - the organ would be considered responsible.

For the matter, Pontius Pilate was an administrative worker. And his incentives were aligned accordingly.

In the language of the Trolley Problem, it is doing nothing (no matter how many are there on the tracks) or (even better) finding a way to pass the lever to someone else.
If you want to use a PWA on an iPhone, you are fully dependent on Safari support. Firefox's decisions here aren't blocking anyone.
Shout out to the Quadra 605, my first Mac. Such a cool computer back in the day and relatively affordable at the time. Used it for many years later as a monitor stand too.
In what character set?
I moved to egpus a few years back and it has been great. I have a desktop when I need one for gaming and a laptop when I am on the go.

anyone who uses a 2nd monitor is also “tethering” themselves to a desk, not sure that is a strong argument.

Futher, cpu speed increases have kind of plateaued, while GPUs have not.

Finally, most laptops max out around ~150-200watts of available power. While that $3000 Alienware laptop may have a 4080, its not a real desktop gpu, which in an egpu enclosure can pull 450 watts.

Finally, a goid egpu box is also a dock, one cable into the laptop, plug and go.
I'd say that people should be allowed to try whatever treatments they agree to have, in order to save their lives, and also in other cases. One cannot say with a straight face that a woman has sovereignty over her body and thus contraception and abortions should not be banned, and preclude that same woman from getting a treatment that can possibly save her life but has not been approved yet.
I disagree. (By CGI you mean, fake reality, such as superman flying through air, right?)

* I saw "3d mesh" overlay which was CGI, at 1:06 https://youtu.be/6zPvT0ig1VM?t=66

Everything else, showing the robot moving up/down stairs, jumping, looked like reality to my eyes.

What other parts of video appear CGI?

Also, look through their other YT videos: https://www.youtube.com/@unitreerobotics/videos they have published a lot of video, also not looking like CGI.

Compare an older model, to SPOT from Boston Dynamics, four years ago: https://www.youtube.com/watch?v=rytwDPIYZ20

EDIT: 11 months ago, a review of the older G1 model https://www.youtube.com/watch?v=09W8EWIZl1k - seems to be real
I’m saying that the FDA’s strictness cuts both ways. My beta blocker example was not a hypothetical.

Europe approved the use of beta blockers to prevent heart attacks a decade before the US. Although the FDA approved propranolol in the 1960s, and timolol for glaucoma in 1978, they didn’t approve beta blockers for prevention of second heart attacks until the 1980s. This resulted in the deaths of over 80,000 Americans. Amusingly the New York Times article about this approval brags about how many people will be helped by the previously-banned medicine.[1] Nowhere is it pointed out that so many more people could have been saved if the FDA fast-tracked drugs approved in Europe.

1. https://www.nytimes.com/1982/02/02/science/new-class-of-drug...
At 640x480 (for the whole screen) and 16-bit color
It already went way too far and consider, the outcome will impact all of us. Now we have to ask an Artifical Intelligence to simplify the complexity of getting a footstep in a Cloud Hosting Platform like Google, Amazon or Microsoft. I don't know if this is desireable.
I still think they need another category than what they have now.

My understanding of the current categories of drugs are you have "banned" and "has this specific therapeutic effect that costs billions of dollars to prove".

A category of "this doesn't kill you" in the middle would probably alleviate most of this. Insurance only has to pay for things with proven therapeutic effects, but you can shield people from poison and get a lot more data way cheaper by having his middle category.
I do think that people should have options, especially when there aren't effective treatments, but it's not exactly simple. In most cases, any treatment you pick has the opportunity cost of other treatments, and for life threatening diseases that opportunity cost might be living. Very few, if any, patients are going to be in a position where they can legitimately evaluate the effectiveness of treatments. In most cases, I don't expect health care providers will be in the position to do that either- even most specialists will be treating a wide variety of conditions, and may have relatively little experience with unusual diseases. Even in the best case, this is assuming that drug companies would actually try to make effective drugs rather than looking for other avenues to sell ineffective drugs (or drugs that were only accidentally effective)- I don't that in today's environment that's at all a reasonable assumption. Ultimately, the information asymmetry is vastly weighted in favor of the drug companies, and the cost is lives.
> unrecoverable panics

Panics are recoverable.
I have pushed production apps in php, go, .net, java, and j/ts. Touched some Django and Rails along the way. For fun I have played with elixir and more I can't think of at the moment.

I'm personally never as productive and happy as when Laravel happens to be the right tool.
TBH I just don't see a difference.
You had me to a point. And then you began the usual conservative dog whistles.

"Words are violence"? If you were dox'd, would that be violence? Or your life threatened? Or those you love? Or just people who look or love like you? Where is the line? Wherever you personally believe it should be? No.
As I work at a cloud provider I have a different perspective on the mix-ins. The problem is that at scale there is no one customer type. Some customers absolutely require a specific way of configuring things, while other customers require exactly the opposite. Cloud providers are always trying to add more features to please all people, its a fundamental side effect of growth. And an often unstated aspect is that the most custom features are often extremely high value ones that were added for customers that worth large amounts of money to the business, even though the other 90% of small users and startups may not need that.

I think mix-ins can be a way to make the growth in features accessible while not overwhelming. Out of the box mix-ins can provide 80% of the value for 80% of the people and the long tail of 20% customers with the super custom needs that are worth high dollar amounts can still build their own custom mix-ins that target their specific use cases.
MIT recreated this thought experiment to research the “morality” in autonomous vehicles.

https://www.moralmachine.net/
Startups are an inherently risky venture that lacks the money and management to hire everyone they want. It's a horrible example.

Consider the empathy from the other side: I'm working in a stable job and my friend approached me saying he's got this big idea. May not even be funded yet. Do I use my part time to help on his dream in hopes that we get funding and maybe expand on the idea? That's a lot of trust and energy being put into another person.

On the end of the "nepotee" it really depends on the person and what you know. And it takes a certain style of mind to get on board that idea. That isn't the same in getting fast tracked to some cushy Google job.
> I'm not totally comfortable with giving someone access to draw from my checking account whatever amount they claim I owe

It's not comfortable, but every time you write a check you're doing exactly this.
(not an MD) The FDA does allow for compassionate use of experimental drugs. My understanding the many early stage drugs are tested this way, but access is limited to trial centers. The author should try search drug trials database to see there's a group that is recruiting: https://classic.clinicaltrials.gov/ct2/results?cond=Head+Nec...
My brother is a physician who is working with patients in drug trials. He had the very good fortune to see an experimental drug successfully treat a very sick, critical patient who was declared a candidate for "compassionate use".
>This is the bug of the year.

Don't forget to knock on wood.
I run in wool socks [1] all the time. Wool is moisture wicking too [2].

1: https://www.smartwool.com/shop/mens-running-socks

2: https://www.rei.com/learn/expert-advice/what-does-moisture-w...
Blackjack is also the most profitable table game in the house (ignoring slots for overall profit). For Texas Hold Em profit is basically just the rake (depends on the pot) and how fast a dealer deals and how fast players will play.

Those card shuffle shoes at the table? Cost $20K each and have be rented I forget the daily rate. The small plastic prism the dealer pushes his cards against to they can see their suit? Leased as well at something like $10/day. If you want to make piles of money invent something a casino needs and lease it to them never sell it!

Just consider the money involved. The table has at least two dealers per shift one on break one dealing. Another reason staff hate card tables high tips to dealers (ignoring all other staff help) and more breaks than any other hourly job. At least one supervisor there at all times. A pit boss who manages overall. The manager of tables or slots (could be both). Security office plus supervisor to deliver chips and take cash boxes away when full and to keep people from getting too crazy which is 99% of the time with table games. Surveillance usually two trained on table games the watch up there overhead via cameras ($20K to $50K each) for one area plus their supervisor and manager. Facilities to clean the area of any food or mess. Servers who server food and drinks.

So it is probably costs $200 - $300/hour to run that blackjack table just on wages alone. Blackjack would make far more per hour in profit.
Do you want the ChatGPT of 3D printed Kleenexes or just regular?
Maybe the fact that these are the ones you remember is an indication of the problem, rather than evidence that it is wrong.
Well, CP/M actually had a number of "user areas", the default one being USER 0. Some tools actually used that to simulate directories (AFAIR they kept the number to name mapping in a hidden file somewhere).
C’mon, it’s extremely disingenuous to compare abortion and contraception with untested treatment.
It was kind of a trick question.

4: Small(talk), Joy, Pro(log) and D (from Odin).
Webauthn should allow use of private key authentication stored on external hardware key or in device.

You really want support for key authentication just like ssh.

You shouldn’t move private keys between devices, you should have easy way to add new public keys to a service when you setu new device.

Problem is permacookies or private keys don’t really allow ad-hoc access but maybe nowadays people don’t need to login to their accounts from cyber cafes :)
Nobody does rate limiting or other abuse work on a full /128. Typically a /64 is treated as the equivalent of an IPv4 address.
> there is definitely a difference between knowledge workers that use it and one’s that don’t

[citation needed]

I tried out Copilot for months and didn't get much value out of it. The majority of my time and effort is not writing code, which is about the only thing an LLM can generate semi-useful output for. It's not more useful than a tailored search engine experience and it doesn't replace deep dives into text books, code, and white papers. Where are you seeing major benefits?
Or they could use Qubes OS, which in some cases is more secure: https://www.qubes-os.org/faq/#how-does-qubes-os-compare-to-u...
Running Minecraft Classics clone in Windows 98
It's one thing to say they should approve drugs faster and another thing to say they should rubber stamp anything that Europe and Canada approve.
Get rid of prescription requirement too - who needs to see a doc for extra $500 when I can go and pick my own med, and possibly better one.
Important in terms of adoption.
How about local storage? Only downside is that this data isn't sent automatically on ever request (unlike cookies). It would be possible though to send this secret from local storage via a separate request and receive a session cookie that then let's you be logged in automatically
Just because a treatment doesn’t work doesn’t make it snake oil. Snake oil implies intent to deceive. Untested drugs can be based on a strong theoretical foundation and still not work. I expect the majority of experimental treatments won’t work. We should be trying regardless, not just for the sake of the people taking the treatment, but for the countless people in the future who can benefit from the same treatment when it does works.

Also we should stop patronizing everyone. If someone understands the risk and their doctor agrees, just treat them.
This is what HTTP auth headers are for, but the UX for using header authentication on modern browsers is utter garbage. There's no way to present a themed login form, no way to log the user out at all, and all sorts of weird papercut bugs[0] in between.

[0] My favorite: opening DevTools triggers a second credential prompt because the DevTools session wants to download some mapfiles or something. No infrastructure exists to make that HTTP request in the context of the current tab, apparently.
I remember Softenon.

> it wasn't only because of low-hanging fruit.

Yeah, right. They had such advanced cancer medication back then.

> Give people with fatal diseases a "right to try" drugs that haven't passed safety testing -- and use that data.

That data is practically worthless.

I'm in favor of having people try out medication, but it will need to be heavily regulated. And we know what happens to regulation: a party comes along that doesn't like regulation, or gets bribed, and the regulation goes out the window. It's a good way to start another opium crisis.
Thank you pointing this out, I was extremely confused.
That’s what Passkeys are supposed to do. You have an identity tied to that website, shared across all your devices.
Scheduling problems are a very well established domain for constraint programming, you’d very likely find it easier to express and solve your problem than with other methods.
No surprise that it's not already implemented because we just throw more cheap hosting and bandwidth at this problem until it's fixed.

The "premature optimization is the root of all evil" misquote really caused a lot of damage to favor growth and profit making instead of better software. It seems programmers have a general habit of just implementing things in the most naive and cheap way and just solve any problem with expensive hardware.

We really need a new trend of fast and minimal software because climate change and a finite planet will not allow us to follow Wirth's law for very long.
Could it be a stalks of higher plants?
Probably different understanding. I'd say VR/XR is still that sort of niche corner but I don't deny that eventually it will blow up. You can certainly fill a conference room with dozens of topics, though.
Not always, but it's usually true.

> Patients generally do not have to pay extra out-of-pocket costs for treatments studied as part of a trial. Every trial is different, but the clinical trial’s sponsor usually pays for all research-related costs and any special testing.

> Typically, the patient or his or her insurance company is asked to pay for any routine tests, treatments, or procedures that would be required as part of standard cancer treatment. Before you join a clinical trial, you will receive an informed consent document that spells out exactly what you’ll have to pay for and what you won’t.

https://www.mskcc.org/cancer-care/clinical-trials/frequently...
Even telling the world that can be useful because what is embarrassingly routine for you might be entirely unknown to someone else. Plus it is simply polite.
>We use the same material to wrap and bake food and drink unhealthy drinks as we do to build airplanes

It's not the same material. There are thousands of types of very different plastics.

>We drive everywhere because of poor urban design

Reversing allegedly poor urban design is the work of decades.
"The short term greed of globalization has resulted in a massive geopolitical blunder."

Agreed, but this 'thinking' has been so ingrained as the norm since the early 1980s—the Reagan-Thatcherite era—it's almost set in concrete. Seems to me it's not going to change anytime soon, unfortunately.
Could it be due to a different disk format? MSX DOS is supposed to be able to run binaries in its own filesystem (FAT12), but I reckon it probably didn't support CP/M filesystems (which weren't unified really, each machine often had its own variety).
>you can of course store them offline

>Today's initial implementation on macOS restricts exporting,

So you can't. Will be able.
How long can Tesla owner earn money with their self driving Tesla?

If you can export and import them, isn't that a security risk?
It may help to not view the options as a binary choice between drugs approved under the current process and any drug not currently approved.

What constitutes the acceptable tradeoff is the heart of the matter. On the one hand, even the current approval process does not always guarantee efficacy (Aduhelm to mention it by name). Medical trials work with considerable uncertainty, and the risk/benefit tradeoff is always a question of probabilities. Even with the current process, there is no certainty or guarantee.

It is possible to take those probabilities and to talk about the expected number needed to treat (NNT) for a medication, the expected side effect profile, how many people might live and how many might die. Things that may sound cold, but that are already routinely done today.

It is hard to know where the tradeoff should be, how much margin of error is the right amount before something is approved, knowing that there is uncertainty even in large trials, but it's not a choice between the totally unapproved and the status quo. (Better yet, we should not model the choice as a single parameter that goes from more choice & more snake oil to less choice & more safety. It's also often possible to improve one aspect of a bureaucracy without it being a zero-sum game.)
If the treatment needs to be administrated by a doctor, it demands the resources of the hospital and connected system, for a novel process. It does introduce a real risk factor for the rest of the healthcare provider’s system and the other people counting on it. I don’t see the comparison you’re making at all, really - a novel treatment has completely different context from an abortion.

Talking about immunotherapies feels like oh yes of course it would be worth it…but should you also be able to print out a blog article about holistic medicine and demand the hospital follow that treatment plan for your illness? Should a person insisting their illness be treated with an untested therapy from a disreputable company get a hospital bed instead of you for the same condition because they arrived first?

IMO this seems like something where the burden on the medical system is at least as much of a factor as the risk to the patient.
Assisted suicide and euthanasia are better examples. If you have autonomy to die, you should have autonomy to die trying not to.
That isn't what brings the money in.
None of your assessment matters regarding how big a deal it actually was. My mom didn’t give a damn about backslashes and my dad had zero use for seeing hidden files. The “state of the art” in 1995 was for nerds doing nerd stuff, Windows 95 was for regular people who couldn’t afford a Macintosh.
Why doesn't it mean that?
> What is the end game for Reddit here?

IPO or sell.

That is it. The bag the buyer(s) are left holding is not their problem.

What really boggles my mind is that the market would buy a burning building like this. Maybe there is some more money to squeeze out, but surely not enough to recover the alleged valuation.