skysight-inc/HackerNews huggingface dataset:
It’s Back: March Madness Higher Education Data Breach Brackets
US clinical trials often involve a second, parallel clinical trial in India, because it's easy to find lots of poor patients in desperate need of treatment. I think that, at least in some cases, this probably works out well for everyone except the control group.

But if poor Indian patients are going to test these drugs, the GP can certainly argue that poor Indian patients should be able to afford them.
How Badly Do We Want a New Java Date/Time API?
"So... how do we figure that? Seriously: How do we do the math in every possible case to ensure I'm not exploiting the person who freely agreed to work for me?"

By "freely agreed", do you mean it in the restricted sense that the worker was not physically coerced to work?
Bayer doesn't have a problem with selling cheaper drugs to poor people, they do have a problem when those drugs go onto the grey market and get purchased by those who could afford Bayer's regular price.

That's why drug companies don't do differential pricing, because they can't stop the cannibalization of their wealthier markets.
Perhaps making drug companies non proffit to ensure all money went back into developing new drugs and perhaps less proffitable drugs (i.e. Drugs targeted at the developing world).
Simple explanation for Big-0
I suppose you are too young to remember "picking winners", Harold Wilson, British Leyland, Red Robbo... Or more directly, Grundy and their NewBrain vs Acorn... Historically, government meddling in industry in the UK has been a disaster.
Tricks to multiply numbers by 9, 99, 999 and so on within seconds
I think many people are assuming this means direct investment but maintaining a high quality, accessible education system is arguably more important.
Northern Rock employed 5000.
Perfect gift for my girlfriend :)
Wow, i watched the first video batch and think it's the best online course so far. Very in-depth, but at the same time incredibly well chosen examples. Initially I was sceptical because the videos seem to be taped lectures rather than the type of screencast I know from mlclass and aiclass, but it's really well done.

There is a notable difference of course between courses like PGM and ML, which go pretty much into details of actual things, while others like AI or crypto will probably naturally stay a bit at the surface, as they are more intended to give an overview. I think they shouldn't be compared therefore. I think the robotics class is a bit behind of it's possibilities compared to PGM or ML, considering that this is definitely not an overview anymore.
Ahem, Acorn paid the BBC a fee for every Beeb sold, as a licensing fee on use of the logo.

Acorn were also almost overlooked in favour of a company called Grundy, which had government backing, but inferior technology.

http://en.wikipedia.org/wiki/Grundy_NewBrain
I'm not saying cover bad R&D - I'm saying cover bad R&D costs for companies that did the good R&D you want to use - because that costs would usually be covered by the profits from good R&D - this is how you structure investing - you make several risky shots so that the one that succeeds pays for the failures - it's a good way to determine "the proper" amount of profit, if you just repay the investment in profitable R&D you will actually lower the investments in the sector.

Anyway the point is moot because R&D costs will probably be paid in the US and other richer markets, India could simply take a free ride. If everyone wanted to do this then you would need to find a way to compensate R&D investments.
But then such designer is not a target for this "Manifesto".

BTW, I see value in having one person create designs as HTML files, but I also know a lot of designers who create beautiful, graphics-rich designs and don't know much about code. I suppose it's much harder to find people who can do both as good as separate people.
メンズエステ小顔口コミ・評判・評価
Comfortable Hotels at Different Pilgrimages
Chardham is the most auspicious place especially for the Hindus. The tour of Chardham is performed especially in between the periods of Akshaya Tritiya and Dhanteras.
Anyone knows if there is a .epub version or something more ebook-reader friendly?
There are probably more than a few HN'ers who are interested in Dennis Richie's take on these things because of their interest in what he thinks. It is analogous to the reasons HN'ers are interested in PG's thoughts about High School.
> Currently we are restricted in selling to private individuals in Austria only.

anybody knows why that's the case?
Implementing Garbage Collection in CS/JS with Aspect-Oriented Programming
US Patent 7406501 ... "Conversion of an instant message to an e-mail message" WTF...Is that it?
Most places I know of are moving away from a the designer and frontend developer positions.

Is just in regards to bare HTML/CSS or JavaScript interaction as well? I’d think most companies would be hard-pressed to find a designer that could write in the full HTML/CSS/JS stack needed for webapps these days and be equally competent in interaction or visual design – as ironic as that sounds – in which case FEDs are still very important in the process.
Study Abroad Consultants in Pune
Tell HE: An Update
I would stop brute force testing simply by putting a limit on it.

As far as I know there are some pretty standard procedures you have to go through. Surely it must be possible to somehow validate and verify whether someone is trying to take advantage.

You can't hinder some taking advantage of it, but you don't have to IMO.

>I doute they cool do that.

Of course they can, just like then can improve many other areas in public service.

>I agree its not very good right know but I don't know how to change it.

Well I for one think its more fair to accept some fraud to make it cheaper for everyone else if possible of course.
EBooks for Programmers Should Include a TXT
That's not true. The GPL wouldn't be unnecessary, it would cease to work. The GPL relies just as much on copyright laws to work as does proprietary software. Something that is disallowed with the GPL is taking the source code, making a modification, compiling it, and then only distributing the binary. There is nothing that prevents this but copyright law.

A correct statement would be that the BSD or MIT licence would be unnecessary (except for their clauses that you have to include the copyright notice with your modified program).
> Then you would no longer have a free market;

And that's part of the point ... These aren't typically free exchanges. Part of the complaints brought on my customers is monopolistic (oligopolistic) practices, including forced bundling, false shortages, region restrictions, etc., coupled with government limitation (e.g., copyright laws).

Additionally, (and this is a point I argue with those proposing wholly market-based solutions to public education) a theorized free exchange with unshackled supply/demand curves assumes perfect information, which we don't have. (In this case, partly due to the long tail of attention.)
Did I say something that was factually wrong?
I think the recruitment rules are just more lax in India, than in the US.
I wish I could upvote this more.

Thank you.
Totally agree, compete on innovation - not by patent troling! Goodbye Yahoo!, shame you decided to disgrace yourself in such a way.
Then we get into the case of having to monitor companies to make sure their bad R&D budget isn't being inflated to give them additional profit.

Better to just negotiate cleanly with the company for the drug you want, and sell it all on your own market like the NHS does.
In this situation who decides what drugs go into clinical trials? The drug companies are in a much better position to know which drugs are worthwhile, but if they don't pay the price they have to reason not to throw everything at the wall to see what sticks.
Most of the 2000 may be highly skilled or at least a large proportion to that of a bank, increasing funding in such a company may increase the number of people taking up science and engineering disciplines in education.
The USPTO hands out patents like a kindergarten teacher hands out stickers. You made a system for ad placement? Good for you!! Here's a patent!!
I really don't like saying this, but here it goes:

Don't hate the player, hate the game.

We need real, substantive patent reform in this country.
Google does that! Quick Yahoo! sue them!
The dots are the "grippy". You can use them to e.g. drag the mail over a label to move it there. In the old design they were always there, but now they are only showed on hover to remove "clutter".
Two Points....

Lazy Man's Version.
1. "People Buy the Hole, Not the Drill!"-Marketing Axiom
2. delink product from price and link price to value.
3. Always compare apples to oranges when selling. the worst thing that could happen (from a marketing and pricing perspective) is your product or service becomes a commodity in your customers eyes.

The story goes that when Robert Kiyosaki first developed his Cash Flow 101 board game to teach kids about money, he ran some focus groups asking how much people would pay... the common response was between $20-$40, which is pretty normal for a board game.
He supposively ran into Dan Kennedy who explained to him that instead of comparing this game to other board games, he should focus on the value it creates and the financial education it delivers and charge like $200 for it. He did this and still sold hundreds of thousands of copies. (it's available on amazon for $99). Drawing the comparison of apples to apples or in this case board game to board game was holding him back in his mind, but if the value was communicated properly, the game actually saves you thousands of dollars of education in a money course, or worse, a lifetime of money mistakes. ALWAYS COMPARE APPLES TO ORANGES. you never want to draw a side by side comparison, because then price becomes relevant. If you succesfully delink product from price, and realize that price is actually by definition a numeric representation of value, you can actually charge what a product is really worth. This is also why a "Unique" selling proposition is so important, you don't want to be viewed as a commodity to your customers, it will only hurt your bottom line.

Smart marketers live by the axiom, "You Buy the Hole, Not The Drill!"
(Although, this concept of selling benefits, not features is only one layer, and there are deeper emotional layers if you want to peel the onion. The better you understand what drives your customers decisions, the more effectively you can communicate the value you are really providing to them. Keep in mind though that you need to tie the benefits into features, to explain how you will deliver that benefit. A good exercise for this is a two column spreadsheet where you outline all the features of the product in one column, all the benefits in another column, and start drawing lines matching them up to each other. Yes, good copywriters and marketers actually do work, they dont just suddenly get inspired :)

There is a great book on pricing strategies by Dan Kennedy and Jason Marrs worth reading if you want to learn how to set your prices properly.
Less than 7 Hours to go for Google Code Jam 2012
http://code.google.com/codejam/

What is your choice of programming language this time around? And how have you been practicing?
FYI, as the author of the link post, I agree - but there's not much I can do about people reposting my linked posts... (I don't think it should be reposted unless I add some insight, e.g. http://swombat.com/2012/3/10/frightening-ideas - and even then, I don't know...)
This is why I use my own domain for my primary email address. If Google decides to pull some kind of crap on me, I can always ditch them without having to write that silly "My new email is" message to all my contacts.
Dito. Although I got a bit weary of people using Genetic Algorithms to do X. Usually, using a GA is saying "I have no flipping idea how my search space looks like", when the truth is "I've got a good intuition what I'm looking for, but I'm too lazy to formalise this and GAs sound cool". And then you go on and constrain your search space on the wrong level by manually tweaking the Genotype-Phenotype-Mapping.

GAs are good a good optimization tool once you've broken down your search space to a domain that is so absurdly small that manually fiddling with parameters produces no noticeable change. For exploring interesting patterns and areas of a search space, the algorithm you're looking for is called "random()".
To continue your silly analogy:

C ~ Unix

This association is a lot stronger than any of the others that you listed. C & Unix were created in tandem and were designed for each other in very many ways. For the first 10 years of C's life it was rarely used outside of Unix. But for the next 20 years or so it became the dominant language for pretty much any large project. It's only been the last 10 years or so where C has lost its domination.

Association with a very popular project has its downsides, but the upsides are much stronger, in my opinion. For instance, would Ruby be as widely known, deployed and used for non-Rails projects if it wasn't for Rails? It probably would just be another "niche" language rarely used outside of Japan. OTOH gem probably wouldn't be as badly broken as it is.
Special powers? They mean by force or arms. There is nothing special about theft except when a government does it they are pretty much immune to counter actions.

This is little different that Greece having passed laws allowing them to retroactively change bond agreements and then implement said changes they claimed were now legal under their laws.

Now if India decided to pay a reasonable fee to Bayer for the ability to have a national drug company manufacture them then I would see little issue here.

Instead they are simply passing the costs to other countries. As in, let those "rich" countries pay for the development of medicines and countries like India will simply steal what they want with impunity. How different is that from what the Chinese do to manufacturers of cars, electronics, and other technology not developed at home.

The cost is simply borne by people they don't have to see or care about. Yes I know the drugs are expensive but development of new medicines is not a cheap endeavor. To have government arbitrarily decide who can charge what and when will simply trade a few lives today for a potentially larger number in the future, that larger number arises because potential treatments may be deemed to risky to research under the threat of confiscation.
IMHO the linked article misunderstood what this is all about.
I think it's more the "Reply to this thread by replying to this email" facebook does when you receive a message notification.
This is a much better simple explanation: http://stackoverflow.com/a/487278

The OP is pretty thin on content. Also is "linear logarithmic" really the correct way to refer to O(n log n) ? I don't think I've ever heard that before.

Also, some of those examples definitely don't compile, due to capitalization mistakes (integer vs. Integer etc) which makes me suspicious that they've even been tested.
When the player is a huge corporation consisting of numerous layers of management, it is very hard not to hate them.

This player will most likely also lobby aggressively to thwart any attempts at reforming the patent system since it is one of its few remaining sources of revenue.
As others put it, the manufacture of simple chemicals in the quantities involved in pharmaceuticals is effectively free. As in, give me 100k and I'll be able to make enough of the drug for the whole world for the next hundred years. The packaging of most pharmaceuticals is more expensive than the manufacture of their contents.

The cost is overwhelmingly in R&D -- finding the chemicals, proving it doesn't kill people, and proving it actually does something useful.
Seo denver
Blue Saki Social Media is a development company focusing on solutions that empower you to promote your business or organization through Social Media platforms.
Not ideal, but you can get composite (CVBS) to VGA converters for about £15 on eBay.
Why the customer isn't always right
Being English, the thought of going back and telling him I wasn't happy with it was horrifying. Especially since he had done a really good job of it. It wasn't his fault that what I'd asked for wasn't what I had actually wanted. But I knew what I wanted now, and I was prepared to pay for it (again).
The OP wouldn't seem quite so hypocritical if VCs didn't put immense pressure on startups to generate patents. Don't tell me those patents are supposed to be purely defensive, either. They were supposed to stake out a bit of technical turf, just like Yahoo's doing. I'm not saying it's right, but I don't think much of demanding patent generation on one hand and then complaining about their use on the other.

If you want to oppose software patents - and you should - then be consistent about it. Either forego them entirely, or require via contract that they be used only defensively. The latter is the approach taken by my employer, BTW, who also spends more money than anyone else fighting software patents. As schizophrenic as that strategy might seem, I believe it's the right one for the crazy world we live in.
Automatic Watches
Eco-drive watches are charge by any lightning source and in deficient light they can works accurately. Also there is no need to change or replace its battery. Automatic watches are also known as eco-friendly watches, they do not harm nature in any way because they use energy from nature.
>> It would force the governments to develop better and cheaper systems themselves to make sure that they can test for cheap.

>I doubt they could do that.

While I disagree with the OP's point in general, this is probably true in a way the OP didn't intend. When testing, each unit of thoroughness you add costs the same amount but catches fewer and fewer mistakes. You generally want to stop adding more tests when the cost of new tests (in drugs that are too expensive to develop) exceeds the cost of letting bad drugs through. The research I've seen shows that not only is the FDA well into the point of diminishing returns, its also probably into the realm of negative net returns on drug testing. Probably because there's a huge public outcry when a drug they approve ends up killing people, but no outcry when I drug that could save lives isn't developed due to too much testing. If anybody has more research on the topic, however, I'd be happy to see it.
Absolutely. It's easy to bash at Yahoo, but we can't forget that while Facebook (and many other players, including Yahoo) are using one hand undermine the "intellectual property" of other companies, they're using their other hand to try and protect their own IP using the same laws.

Take this absurd Facebook patent as an example

>System and method for dynamically providing a news feed about a user of a social network (US2008040673).

While the situation is different, as Facebook aren't suing anyone (yet), we can imagine if the roles were reversed, the story might be a little different. Why else would they file for patents if their intent wasn't to defend "their ideas."

If we're calling out Yahoo's patents as junk, we should be doing the same for facebook and the rest, otherwise we're turning a bad system of "who dunnit first" into an even worse one, a popularity contest.
Because that's probably not why they suspended their account, PayPal suspended their account because it triggered a potential fraud tripwire.

The owner just won't be able to unsuspended the account because they're in violation of the rules. If they weren't in violation they could just supply the required verification documents and get their account unsuspended.
> I used to care about that company for some reason

That's the strangest part. I never found Yahoo useful for anything (except Douglas Crockford, but he could have been employed anywhere).
SQLAlchemy is "complex" in both #3 and #4, so it wins in #4.
It's quite possible that Fred's actions do make him a hypocrite here, but can you show that they do, rather than waving your hand at him and calling him a VC?
I agree completely. While Y! is clearly acting in desperation, this is an obvious and predictable act given the legal system in which they operate and patent portfolio they have. We can (and should!) demand that they not do the expected, but I the think anger is better focused on systemic reform then getting angry at any single company's actions. In a system of laws, what else should anyone expect but a legal entity to act in what it sees as its own best interest. Software patents need to end; working to that end is the best way to deal with this sort of event.
> By "freely agreed", do you mean it in the restricted sense that the worker was not physically coerced to work?

Only as a first step; it has to be more complex than that, which is one reason unions exist (in the ideal world with ideal unions that accurately represent the needs of the people they represent).
Show HN: Introducing the Entrepreneurial Hackers Group
Welcome,

I am starting a company. I am 27 and I have no idea what I am doing.
Does that sound like you? Well its happening to me, and I need and want help. I want to know the right answers to things and I want to know them now instead of later, well because I am in the process of starting my company.

So what did I do? I created a Google group. https://groups.google.com/forum/#!forum/the-entrepreneurial-hackers

This group has been done plenty of times before, but only in select locations around the globe, that are local to that city. Here is the solution. This one will not be local. It will be world wide. I am tired of trying to rely on my questions being answered on Hacker News and Pleas for help. I want real solutions and answers to my problems.

I did this because YC does it, so why not? Did you know YC has a network of people they could ask on their own group and within minutes, have it answered? I want the same thing. Im tired of this exclusivity, and I want to fix it now.

So here it is. Go ahead, ask the first question. Its up to you to see this place grow. We as entrepreneurial hackers don't have anything yet like this that isn't open to the general public. So here is my first attempt.

My 10 cents.
Movitz is one: http://common-lisp.net/project/movitz/movitz.html and http://trac.common-lisp.net/movitz for where to get the code.
Serious question. Was it a disaster or did they just pick the losing team?

Sometimes the government picking a loser can still cause a market to expand.
Now that Django 1.4 has dropped support for 2.4, compatibility with 3.2 is going to be a lot easier. There is an experimental branch that Vinay Sajip has created https://bitbucket.org/vinay.sajip/django/ which I believe is being considered for merging in time for Django 1.5.
Circa: Cheezburger's Ben Huh Wants to Break the News So He Can Fix It
There are a finite number of useful small molecules you can use as drugs. If it's costing 3-12 billion to find new ones and even then we are failing we may be at a point where it's time to 'give up' on our existing approach. As an upside we can remove a significant slice of our spiraling healthcare costs. We can also remove a lot of drug related advertizing that has dubious healthcare benefits. Unfortunately, that also means antibiotics are going to become infective in the not to distance future.

On the net I don't think this is a good thing, but it should free up a lot of vary intelligent people to work on other lines of research. Hopefully, we may eventual start to develop the tools to build direct DNA specific medicines on the fly by using the fruits of those other lines of research.