skysight-inc/HackerNews huggingface dataset:
we've gotten pretty good at predicting proteins from genome assemblies, but we don't have the manpower to manually curate that data.

Swissprot, the project that manually curates and scores protein sequences, has about half a million 'supported' protein models in its last release: https://web.expasy.org/docs/relnotes/relstat.html

TrEMBL, the database that has curated + uncurated, has 249,308,459 proteins in its last release: https://www.ebi.ac.uk/uniprot/TrEMBLstats

Generating uncurated protein sequences has become fairly easy - I can generate a draft genome assembly in about a day, predicting proteins using MAKER or BRAKEr or other HMM-based pipelines takes another day or so. Most eukaryotes have about 20,000 to 30,000 genes that translate into proteins.
I'm involved in a project that assembled 300 draft genomes in the last 6 months- now we have between 6 to 9 million proteins (most of them not 'novel' in function - novel genes/proteins are rare, and a HMM trained on known sequences cannot easily find novel genes).
Their low end models are just rebadged Lexmark printers while their high models are rebadged Samsung printers (the same IP that is now owned by HP).

It is a shame that they stopped developing their own models.
Not anywhere near. I’m just an interested observer, but the nearest is ‘synthetic life’ which takes existing cells and removes/reworks/replaces the existing dna.

https://www.cell.com/cell/fulltext/S0092-8674(21)00293-2

Even the cell membrane is fantastically complex. Keeping out the bad stuff and letting the good stuff in. While keeping the good stuff in and letting the bad stuff out.
I have worked professionally with Rails since just after 1.0, on applications of every size.

The number of cases where applications sanely used features of rspec that couldn’t have been done equivalently and just as easily (and significantly less confusingly) with minitest-based tests are few and far between. And these are easily outnumbered 20:1 by insanely bad test suites that abuse rspec and thoroughly mock everything in their tests, resulting in tests that a) are so brittle they fail on any non-trivial refactor, and b) couldn’t possibly preemptively catch buggy behavior.

I have quite literally never worked on a Rails application that used minitest and which was forced to abandon it due to unmet needs.
Nonsense. One's life meaning is traditionally simply their social role. The reason people lack meaning now is that we started determining our social roles by way of market whims, which means our roles are temporary at best and imaginary at worst. It also creates a market for braindead individualist philosophizing to explain why everyone feels so lonely and lost. Sterile precarity is the problem, not the solution.
strangely, I think its because of the difficulty in producing and distributing existing inks / laser toner. Perhaps if the printer was able to use the most common commercial cartridges it would be feasible.
Brother already started doing that. You could go with Canon instead.
The following 2 statements can (and are) true simultaneously: 1. most steel is recycled 2. most produced steel comes from iron ore, and not from scrap steel.
The two are not mutually exclusive, in principle. Depending on workflows, sizes, and change frequencies, each has advantages. Sparse checkouts are useful with small files that specific individuals can focus upon, among other things. This is for keeping server-side repo size small in versioning larger datasets that change daily and for avoiding the requirement to have a sparse checkout of those large datasets in workflows with incoming data, in the first place. This is an interesting use case: https://news.ycombinator.com/item?id=35763004
GPT4 struggles with things for sure, but this isn't one of them. You're just projecting what you think should be the right answer. If it worries you that much, try adding "Provide alternative responses to this question. Each response should try to answer using a different approach to solving the problem." to your prompts.

If you want an example of something GPT4 has a hard time with, try this:

there is no 'e' in the color red, right?
Yes, that is correct. The word "red" does not contain the letter 'e'.
tl;dr: Living organisms polymerize amino acids using ribosomes which are complex machines made up of proteins and ribosomal RNA (i.e. see 16S in prokaryotes[1]). This creates a chicken and egg problem in early evolution because only simple polypeptides - a chain of amino acids before they've been folded into a functional protein - form spontaneously and they do so in basic solutions that make RNA unstable.

This study found that boric acid acts as a catalyst to successfully polymerize several amino acids (alanine and glycine up to 39 peptides long) in environments with acidic and near-neutral pH levels at 130C, which resembles that of the primordial earth. This would be just a tiny piece of the puzzle but it shows that polypeptides could start forming alongside RNA to bootstrap cellular machinery. This leaves many questions unanswered like how did the polypeptides fold along with RNA into the first ribosomes.

[1] https://en.wikipedia.org/wiki/16S_ribosomal_RNA
Democracy is far, far, far more than just mere voting and that fact that you believe this basically just proves the original point.
For sure, especially for fonts geared towards programmers and technical uses where numbers and symbols matter a great deal. A person could probably figure out that he110 is "hello" but as identifiers, he110 and hello are not interchangeable.
Most.

When I was taught piano as a young kid (I stopped after some months or a year) I was taught to start learning how to read sheet music through numbers. Which was a mistake as numbers are important to my brain (OCD counting).

For others (I have an anecdote but it's not mine so I won't share it), only if they can afford private lessons. Which has an impact on opportunities in high school, and consequently on college, if one goes to college. Raw talent only gets you so far if sight reading is expected.
incredible and so inspiring. thank you!!
What are you thoughts about Canon? I just brought one recently. It has an option for me to opt into disabling support for third party toner cartridges. You read that correctly. It lets you use third party toner cartridges by default and if I do not want to be able to use them, I can opt into disabling them.

On the other hand, Brother prevents cartridges from being reused more than once, which likely kills the market for remanufactured toner cartridges.
i really enjoyed it as well. Also there’s seems to be a movie in the works based on it
For anyone else wondering IMO= International Math Olympiad. [0]

I think it’s funny when articles are so deep into their topic that they assume you know what their abbreviation is.

[0] https://en.wikipedia.org/wiki/International_Mathematical_Oly...
Misappropriation of likeness, fraud, etc.
They started cracking down on that a year or two ago:

https://www.reddit.com/r/printers/comments/s9b2eg/brother_mf...
Some inactive users are legit dead with friends still on the platform. It’ll be very mean to erase records of such accounts.
That’s a bit dramatic, isn’t it?
> absolutely. one can learn Objective-C in an afternoon if you know C

...See, that last part you toss off as if it's practically a given, but it's really not.

Sure, when I was (and probably you were) first going to CS classes, being taught C was pretty much the standard thing. But that's much less true now, from all I've seen.

And why not? 20 years ago, it was much, much more likely that if you were a programmer, you were going to be working with C code at some point. Nowadays, you can easily have full mastery in a dozen different languages, all of which are in widespread demand, and never touch C. (Or C++. Or C#. Or Objective-C.)

Personally, where I am at this point in my career? If I wanted to write a small utility program that runs natively on macOS, I'd pick Swift over C 10 times out of 10. I'm roughly equally familiar with both of them (which is "moderately"), and I know enough about the pitfalls of C to know that I don't want to deal with them, and Swift handles almost all of the frustration of memory management for me.

Plus, there's a single authoritative source for information about Swift for when I run into something I'm unfamiliar with, forgot, or got confused about. If I try the same in C there's literally thousands of different sources, of varying authority, across every major and minor platform that's ever existed, and every version of C. It's fantastic that there's all that information out there, don't get me wrong, but when I'm trying to write a small utility to solve a specific problem, every time I run into something that's talking about the wrong C version, or the wrong platform, or just plain has bad information, is going to add one more bit of frustration that's likely to make me quit trying.

Yes, Apple's documentation is imperfect—but I always know that it is there, acting as a single authority for the language.
At the time you could download the public comments on the FCC website. It was just a ton of copy/paste entries. Useless.
True. Though I also expected to "Reactistan" somewhere more explicitly, I wonder if it is scattered in Fronterra continent?

I am also puzzled myself why the algorithm has separated Fronterra from another large island to the west, seemingly related to node and some other JS libraries. Decided to keep it all as is in case I'm missing some reason
The context in which frankl wrote this was as a concentration camp survivor, quite different than the postmodern capitalist lends you seem to be evaluating it through

Notably, man’s search for meaning was 1946 iirc and postmodernism didn’t really ascend until some time later
I don't know about never. Strawberry picking robots seem to be in the piloting phase (out of the lab, not yet in mass production). Same with harvesting salad greens, and grape picking. Other fruits and vegetables look like just a matter of time and investment.

As we move down the robotics learning curve, prices will fall to the point where investment for designing blackberry pickers or cherry pickers (for example) is affordable.
Happy to see Stanislaw Lem on this list! He was obsessed with humans not having the capability of seeing or understanding aliens.

His Master's Voice is about a SETI-like project that found a recurring signal, and the international effort to decode that signal (spoiler: it fails, gets defunded, the book ends)

Fiasco is a bit more 'normal' in its first contact story, but here too the communication fails abruptly for no apparent reason. Eden is my favorite - it's a bit like the Rama books, a space crew explores an alien land and can't make heads or tails of it.
Yesterday I saw a graph of how money these operators make each second, revenue is in billions, a ~600k is like a business trip cost for one of the executives.
It's also about public sentiment towards the companies and their interests. Comcast, for example, as a long history of trying to silence its critics[1][2].

They want to make their critics look like a minority or as if they don't exist at all, especially when much of the criticism is grassroots and organic from actual telecom customers who are often stuck with a monopoly's service.

[1] https://www.salon.com/2008/06/09/comcast_2/

[2] https://www.cnet.com/tech/services-and-software/comcast-accu...
This is an awesome article, but I was hoping for a copy of the final source and MAKE files on Github...
One of my favorite alien stories is _The_fourth_profession_ by Larry Niven: https://libcat.ru/knigi/fantastika-i-fjentezi/240989-larry-n...
Well exactly. If we did we'd be on or a hell of a lot closer to describing the math, entropy, network or some other formal model of it which would pay major dividends to talking about AI.

Right now it's like we didn't learn anything from Wittgenstein who said most philosophy was just argument about language and definitions ... which is a lot plus anecdotes of what we read here
By "their opponents," I meant opponents of the previous Twitter owners.

The neutral platform is gone. As we were so often and so smugly reminded, Twitter is a private company. They can ban who they like. This is the dog-eat-dog public discourse world you chose.
“Example from the Soviets”? Buddy that actually happened. You don’t get to deny the truth just because it is inconvenient or makes you look bad.
We can choose our social role. We can choose the market we want to serve.
haha, I love the flags idea :). I wish I had the prowess to implement it in a way that is visually appealing and not obscuring the map.

I would also love to have a giant octocat hugging the archipelago, with some radial gradient emitting inside of it. Alas my design-gl foo is not there yet
This will seem quaint after everyone starts using the generative AI models in sybil attacks.
Children are an insurance policy - negative EV for sure, but if you raise them right, and they do alright, and you hit skid row in your dotage then they’ll take you in and provide free food and board for the rest of your life.

Ice floes were always a risk to policy fulfilment, so Boomers invented Global Warming to remove them.
> nobody is ever going to use a language with a semantic but no implementation

I appreciate what you're saying, however, hear me out. Suppose we had a language with a defined semantics and a useable implementation. We could use that language to implement, say Rust, and in so doing have a semantics for Rust, a semantics defined by its implementation. The point is, to be principled, we have to start somewhere. Make that language basic so that we are capable of providing a semantics. Now, granted, the "semantics" we generate for Rust in doing so will be necessarily pessimistic, i.e. overly determined. But then one could develop tooling to "prune" the implementation defined semantics somehow towards an idealized semantics. I don't think anyone has seriously pursued this avenue of thought.

Also, I must add, I appreciate your thoughtful elision from my quote. I need to stop getting worked up. But truly, software feels like it's perpetually in the dark ages. We have such incredible compute power thanks to the tireless effort of hardware engineers, and still we're programming with the equivalent of "stone knives and bear skins".
“Success is the progressive realization of a worthy ideal“ — Earl Nightingale
Why is there CODE running inside of an ink cartridge in the first place?!?! Let alone code that's sophisticated enough that "cheaper rivals" can't just copy it. What is going on in this world?
My B/W laser printer doesn't have a yellow toner cartridge. How are the yellow dots printed?
This isn't a meaningful tautology. "The system is unjust because it is unjust and therefore must always be unjust."

We can and should improve society.
My Samsung printer does not support networking. If I want to put it on the network, I need to put it behind a print host.

That being said, at least Samsung toner is cheap:

https://www.aaatoner.com/blreto4.html

I can get 1kg of toner for my printer for $35 before shipping. The cartridges only hold 90 grams.

There is even a third party chipless update to disable the chip:

https://inkchip.net/laser/

Unfortunately, the imaging drum is integrated with the cartridge, is not meant to last and HP is not making new ones. I do not know how many refills I will get out of it. However, the starter toner cartridge lasted 8 years and I replaced it with a regular cartridge at that time, so it will be a long time before I need to refill its replacement.

That said, I felt betrayed when Samsung sold its printing unit to HP too. :/
First, I'll admit I did not read the whole thing. I read a page, then gave up since the first page was bs, and I'm not interested in reading BS.

The example he gives is on English lettter caps. AÃnother language goes above EÊnglish caps. You want the base letter the same height though. You also have high things ̿̿ like this and low things ͓͓ . This all needs to stay in that box.

Since the author seems to not realize a font is more than English [[:alnum:]], I saw no point in reading further.
It seems the thing to do, before you dump toxic chemicals into the water or whatever, is to open a corporation. "Mistakes were made", after all.

This is only trumped by by sovereign immunity, for starting wars or oil spills or releasing viruses or whatever. "Bush is gone, let's move on - why are you still on that?"

State Power is great isn't it?
Yeah I just wanna paste this and found your answer :P, now we have another similar tool about Github, much more useful for many people, kudos to the author!
It should be piercing fines that director and officers must pay and can’t be covered by the company in any form including D&O insurance.
The facts regarding crude futures dropping to negative a day in 2020 are actually more to do with the fact every bit of storage in the US was full. The companies closing contracts were hedged by this point anyways, as demand had all but dried up completely. Perpetual futures would go against the entire point of having contacts for specified length of time. That point is time itself, the other major variable in finance.
Why are the people who ran these companies not in jail?
> Post scarcity has more to do with divorcing labor from production

For almost everything, we’re there. Especially when it comes to food production. There’s still some employment to be had, but precious little when compared with the number of people who can be fed by that limited labor.

For most of our basic needs, this holds true. Yet, the economy demands our labor, arguably hallucinating jobs into existence to meet those demands.
How is soliciting nudes from a minor not already a crime? And having them in your possession is child porn and a felony, right? Wouldn’t this be sufficient for the FBI to get involved.
While not directly related to the question, I wonder how things for universities for mature students, doing post grads? while there is non discriminator policies how they are in practice?
Slap on the wrist? Lol. $61.5m would be a slap on the wrist. $615k is a tip.
Is any video out of this yet?
Unless you're using one of the gcc rust compiler reimplementations it only ever uses LLVM. MSVC can't compile rust, and the rust compiler can't use MSVC to compile things. What rust & LLVM support is various ABIs on windows, meaning your rust code can link windows libraries (and the other way around).
I'm quite unhappy with SBCL located in Schemaria:

https://anvaka.github.io/map-of-github/#12/13.469/-8.175

It should be Lispaña.
I have a HP PhotoSmart C3180 that predates that program. It did not work well with third party ink cartridges, but it could be that HP did something in the firmware to sabotage them. I have since stopped buying ink cartridges. I only print using laser printers now. The HP is nothing more than a high resolution scanner at this point.
You made an interesting observation, but in my personal experience, educators can help students by striking a balance between rigorous fundamentals and getting to improper-but-enjoyable interactions with a new skill, when teaching a new subject—if the student isn't already strongly self-motivated.

My personal experience is with language learning, which might be comparable to focusing on sheet music and scales. When learning languages like Mandarin, Japanese, or Arabic, you can spend a lot of time focusing on fundamentals before getting started with how to say basic useful phrases (e.g. proper tones for Mandarin, and the alphabet system for Japanese and Arabic).

I spent more than a month learning the mundane fundamentals of tones in Mandarin before learning basic useful phrases. I was personally strongly convinced this was useful and was prepared for the mundanity, but I could easily see myself or other people quitting after spending several weeks without knowing more than a few phrases. With Arabic, too, I spent weeks with one teacher just focusing on the alphabet and how the letter shapes transform in certain letter combinations, without learning more than very basic phrases—which I appreciated, as the strong basis paid off down the line. Another teacher, however, spent about two-thirds of the time on phrases with romanization with English letters, and about a third of the time on the alphabet.

~~

For learners—especially adult students—already convinced about learning a subject, a mundane approach is acceptable because they already have the proper motivation to learn. But especially for younger students, perhaps it's okay to spend a good amount of time having fun learning the subject—but not in a way that's necessarily optimized for time.

For adolescents learning musical instruction, a better approach might be a split between theory and learning to play a simple but nice song without knowing how to read notes. But for already strongly-motivated students and/or adults, a few weeks or even months on more mundane can be even preferable, especially if the student has volunteered to spend their time working through the mundanity.
Heat pumps don’t make you sweet, sweet bitcoins…

There was a company in France, I believe, which offered heaters that had builtin computers to render 3d graphics and heat the space. Not sure what happened to them or if they’re still around.
'Elon Musk Fans furious about new Twitter CEO'

A controversial post from Elon to throw shade on his appointment of new Twitter CEO, Linda Yaccarino?
Are you sure? That's it? I seriously doubt it. Your claim too heavily relies on a presupposition of what is to be shown. Somewhere between the four fundamental forces and us is zillions of light years of unexplored blue sky. Please meet the rest of us there
Authoritarianism will reliably produce such outcomes regardless of the economic system or ideology at play, and violent revolution/vanguardism will reliably produce authoritarianism.

Vanguardism and violent revolution are a failure, that doesn't make capitalism the only alternative. Indeed, that's entirely orthogonal.

Plenty of capitalist states have committed similar atrocities. An obvious example being the early United States - the transatlantic slave trade and the various death marches inflicted on Native Americans are every bit as horrifying as the crimes of the USSR, and were committed explicitly to obtain labor and real estate (notice these are both forms of capital) for our burgeoning capitalist economic system. Yet the people who claim the USSR proves communism is necessarily violent don't seem to take this as evidence that democracy or capitalism are similarly irredeemable.
The liquidity would be terrible and all retail trading. Most CME futures are bought and sold by Market Makers, not us retail little guys. The liquidity on Nasdaq (NQ) or S&P (ES) futures are so impressive that I can put in a sell stop order with a limit of only 1 tick from the stop and it will always fill outside of major market events.
And often you'd take those laser printed proofs to a darkroom and produce plates that way for mass printing.
> At least with HTML email, I can already link text to an arbitrary link.

The sender doesn't have to link to anything. Merely writing some non-whitespace characters, followed by a dot, followed by a TLD can trigger client software to automatically create a link, e.g. mentioning "attachments.zip" could cause client software - that is trying to be clever - to create a link to https://attachments.zip which might serve a malicious zip file. The receiver will think the sender created the link, but in actuality it was their own software that created it trying to be clever.

> This whole thing doesn't seem that important to me.

This affects any client software that creates auto-links for TLD's. The "solution" is software must never create an auto-link in the absence of a protocol, e.g. never auto-link "example.com" but "https://example.com" is ok.
$615k is a stern look by a grandma whose eyes cannot help but betray just how much she loves you.
Should I rename Schemaria to Lispania?