skysight-inc/HackerNews huggingface dataset:
> That it’s absurd how much suffering the human mind is capable of experiencing.

When I was 8 or 9 I had a night terror that involved some sort of life-sized game of Tetris that was moving terribly fast. My brain wholly adopted the belief that if I were to lose, everyone I loved would die horribly. I was trapped in this night terror for what felt like forever. Afterwards I refused to sleep voluntarily for weeks.

To this date, nothing has come close. I would describe the feeling as “dread.” Just complete, pure dread.
LSD, like certain other hallucinogens, is a serotonin analogue, and its immediate effect comes about through binding to serotonin receptors, in particular one called the 5-HTP2A receptor. Since any meaningful discussion of this requires a certain degree of background knowledge:

> "In terms of visual perception, the 5-HT2A receptor has been found to play a role in modulating the processing of visual information. Specifically, activation of this receptor has been shown to enhance certain aspects of visual perception, such as the perception of brightness, contrast, and spatial frequency. This effect is thought to be mediated in part by the 5-HT2A receptor's ability to increase the activity of neurons in the visual cortex, which is the part of the brain that processes visual information."

> "Interestingly, the 5-HT2A receptor has also been implicated in altered states of consciousness, such as those induced by psychedelics like LSD and psilocybin. These substances are known to activate the 5-HT2A receptor, which is thought to underlie their profound effects on perception, thought, and emotion. However, the precise mechanisms by which 5-HT2A receptor activation leads to these effects are still not fully understood and are an active area of research in the field of neuropsychopharmacology."

So, let's consider the question raised in this post, which is: "how a could a temporary substrate-receptor interaction result in a long-term effect that persists well past the biochemical elimination of the drug from the user's system?"

I don't think this is uniquely applicable to LSD vs. any other drug, by the way. Some people might try an opiate-class drug once and develop an immediate craving for that experience. However, this really cannot be attributable to the basic drug-receptor binding - so it's probably something to do with neuronal rewiring of some sort. If neurons respond to the immediate drug experience by forming new neuronal connections to other cells, then this could explain how a long-term effect (visual snow, opiate craving, etc.) could be created by neurons seeking new connections in response to the short-term effect of one-time drug use.

Profoundly, it seems our brains are always rewiring themselves in relation to various stimuli and experiences, but LSD and similar drugs are affecting this process at fairly low levels in the neuronal hierarchy.

Note that this is precisely why many people have said that the psychedelic drug cohort, under controlled conditions, has unique potentials for curing various mental illeness-related conditions. The use of the potent hallucinogen ibogaine to effect long-term cures for opiate addiction is one such case:

https://pubmed.ncbi.nlm.nih.gov/28402682/

> "Conclusion: A single ibogaine treatment reduced opioid withdrawal symptoms and achieved opioid cessation or sustained reduced use in dependent individuals as measured over 12 months."
Wonder if the first time he drank he chugged a fifth of vodka.
Not about the core of the article, but how often are folks using something other than the id column as primary key and having id be a foreign key? This seems extremely confusing to me.
When folks say that marijuana's a safe drug, it's purely in reference to the fact that it wont kill you. 100 shots of tequila in an hour will cause death; 100 tokes of marijuana will not. The problem this results in is an interesting one: marijuana growers are constantly increasing the per gram density of THC/cannabinoids in their plants. The consequence of this is that today's marijuana, compared to that of the '70s, is like drinking Everclear vs. drinking a bud light. I've avoided using marijauna for a long long time now because of this; there's just no way to have a controlled slow buzz with marijuana.
My first mushroom experience was a similar dose at home alone. I was a teenager and sneaking it in after high school. It probably wasn't the best idea, but the experience I had was pretty amazing.

I am the sort of person who likes to do these drugs alone, put on a record, and chill (although I do also immensely enjoy being in nature).
This is limited to the Mac App Store. I’ve seen the same on the iOS and iPadOS app stores.

Either way, sketchy devs are capitalizing on the “gold rush” of generative AI.
Somehow more comforting than shouting it all into the void.
> Legalization leads to better education

It also leads to more cases of abuse. Like many things, legalization is both good and bad at the same time.
I think their innovations are mostly going towards scaling supply and manufacturing now. They’ve scaled their large-can batteries, they’re finally starting in earnest on Semi and Cybertruck. And FSD has been improving.

To your earlier point, I have literally never once had to wait to get a supercharger, the route planner takes number of open stalls into account. The non-Tesla experience, idk, and we only use them on road trips, so we’re generally not going to any inside big cities, so maybe that’s the difference. Also not in the Bay Area, so they’re not the local “Camry” yet.
I had a really bad experience with marijuana. I'd tried it a few times before, but it always had literally zero effect on me (as in I smoked as much as everyone else, they got baked and I felt nothing). And then one day I took a single hit in a shop in Vancouver and was almost instantly hit with brain zaps. It got so bad that I couldn't walk without throwing up, had trouble seeing, and this lasted for hours (from 10:30 am until a little past midnight when it finally subsided enough to sleep). Never again.
To make things worse, the neighborhood crack heads have discovered that the charging cables can bring in some decent money.

Neighborhoods are having problems with theft, and from what I've been told, those charging cables aren't exactly cheap to constantly replace.
I’m sorry, but are you saying that drugs categorically can not lead to inspiration that can help creativity?

Aldous Huxley would like a word…
This will serve to protect millions of users. Upon contacting SPAMMER ROOTKITS recovery, I was shocked and amazed to learn that SPAMMER ROOTKITS Recovery had assisted me in recovering my account, which I had lost to fictitious online investors. I had seen a slew of people who have commented about SPAMMER ROOTKITS Recovery, and I kept wondering if they were truly an expert and not a scammer like the others. I'm really delighted to share this story with you all, and if your BTC trading account has been compromised, you can also get in touch with them (spammer@fastservice.com) or (+351920258835).
I need more of this story
As individual how does one get a copy? Last time I checked it's for company only.
This should be tagged (2004)
> When it comes to meat production, we have already reached the steady state.

Well yes but also no, we've reached a steady state. If we reduce meat production we would reach a new, lower steady state which would buy some more time.
"Plan 9 failed simply because it fell short of being a compelling enough improvement on Unix to displace its ancestor.

Compared to Plan 9, Unix creaks and clanks and has obvious rust spots, but it gets the job done well enough to hold its position.

There is a lesson here for ambitious system architects: the most dangerous enemy of a better solution is an existing codebase that is just good enough."

Source: https://www.catb.org/esr/writings/taoup/html/plan9.html
I didn't realize it was possible to use it without disabling SIP, excited to give it another shot! AltTab with a few modifications is currently my preferred way to manage windows.
Many people I know (myself included) started in the second category in the 1980s and 1990s (C = God's programming language) and then moved to the first category once attractive alternatives (e.g., Go) that met our use cases became widely used.
Reading the various comments on this article, I get the feeling that drugs are russian roulette with a random number of bullets in the barrel.

Some people enjoy that. Not me.
Lying in a bed and puking from shrooms and thinking this was horrible is not a experience that should lead you to take LSD.
In the community I know, now one would give him anything. We decide to give newbies smaller doses and sometimes we say 'not you', just based on how the people are in their normal life.
For me the writer sounds like a guy that doesn't like to lose the control and needs to know what happens and can't lean back and give the rudder out of hand.
Thats OK in normal life, but not when you take LSD.

Just to say it clearly, LSD enriches my life, and I know a much people that feel the same way. But it's definetly nothing for everyone and when you think about taking it, don't do it alone in your room. Find people with experience, not every week experience(!) and talk to them if it's a good idea and if yes, go to the woods and have a nice trip.
Ah this is from the creator of the 'rcmd' tool. I absolutely love it. Press the right command key + the first letter of an app and it switches right to it! (rcmd + for firefox, i for iTerm, s for Slack, ...)

I came from i3 with 8 predefined windows, but the simplicity of rcmd is really amazing.
> This is done by using chemical treatments to destroy the oxygen

I couldn't help thinking of the fictional weapon used against Godzilla:

https://godzilla.fandom.com/wiki/Oxygen_Destroyer
> Even if you are into the remote/outdoorsy stuff, an EV is a perfectly viable second car.

This has been my conclusion - the main problem at that point being the sheer cost. My household’s current secondary car is one that cost $10k a decade ago. (Two years old at the time of purchase.) There’s no EV that’s even in the same ballpark for cost-per-km or cost-per-year. (And for a second city-only car, they almost all come with far more battery capacity than is required, adding weight and expense. The Mazda MX-30 EV is probably closest from a technical standpoint with 160 km of range, but still has a cost problem, starting at $40k locally after taxes and credits.)
I’m talking about personal experience.

Is my experience universal? Of course not.

However, the data on that page has massive sampling bias.
I'd bet a large sum that the price of licensing the Star Wars brand is a greater part of the cost of a Lego Star Wars set than all of the plastic in it.
I think I know the feeling exactly. I had recurrent dreams like that as a kid, that somehow always involved a large yellow sphere / ball. For some unknown reason I HAD to move that sphere, but I also knew it was impossible. It evoked this odd and terrible sensation emerging from two opposing mental forces: there was something I HAD to do at all costs but I also knew it was entirely impossible at the same time.

My “bad trips” brought back that same feeling, but magnified by a thousand.
I first stepped on my own LEGO bricks (usually blue bricks that were part of some space station). Now, I equally proudly step on the bricks owned by my offspring. It's wonderful that some fascination transcends generations.
Except of course we can't know for sure the anecdote was an example of LSD causing visual snow, the drug might have been spiked or it could've just been a coincidence...
Anecdotes are at best a clue that there's more research needed. Unfortunately for many people they're also often far more memorable and even convincing than cold hard statistics.
Depending on how much language support you want, you may want to compile without the D runtime (in which case you only have access to the C standard library, and various features are disabled, such as classes/interfaces, garbage collection, exceptions, and most of the D standard library). You can disable the D runtime in GDC with -fno-druntime and in LDC with -betterC. With those flags, the basic hello world program looks like this:

import core.stdc.stdio;
extern (C) void main() {
printf("Hello world\n");
}
Nocebo effect can be also pretty bad, question is, has LSD significantly more bad side effects?!

Is their a way to mitigate the nocebo effect of LSD? Setting helps? If you believe LDSD is bad or can be bad, then don't take it!
I have been using slackware with ion/notion WM for about two decades now and little has changed which is why I stick with it, I have no interest in having to relearn my system every update. In all these years I have only encountered one system change that caused me any grief, when they finally gave into PulseAudio I had some headaches but it was only an issue for me because I use my computer for music/recording and not really that big of an issue since Pulse had been out a good many years by that point and the solutions were easy to find.
No but Amethyst does

https://github.com/ianyh/Amethyst
> Halfway through my trip, about 4 hours in, visual snow started appearing on everything.

> [..]

> “Do you all see this too ?!”

> “Oh yeah, I have that. Don’t worry, you learn to live with it.”

> “LEARN TO LIVE WITH IT?! No way! WTF!”

Hehehe, I had this after an MDMA trip. The sky turned into a giant Brownian motion/visual snow playfield, to the point it was hard to see some clouds. Imagine my surprise next morning when I woke up and it still looked like that. It did go away after a couple years.

The bigger surprise was when night came and my friend realized he was still terrified of _the moon_.

But I agree with his friend, it's weird at the beginning but not actually a big deal. It turns out the sky could look different and it doesn't really matter.
prior to the api nerfing https://www.theblockbot.com/ had a blocklist you could subscribe to that did that.
I get where you’re coming from but I’m comparing two drugs here, LSD and Alcohol. One of those communities is underground, mixed use with harder drugs, associated in large part with people who are “less than” in society. There’s no way to get well tested, accurately dosed LSD without performing those tests yourself.

The other community has companies controlling everything, ads playing to all ages permanently, they have full control over their branding and marketing, etc. They also lobby the federal government to keep doing what they do.

If LSD was as legal as alcohol, and as successfully marketed, I think at that point we could draw conclusions as to which drug is more of a detriment to society and peoples’ health.
In Europe we bring the cable to AC chargers. DC cables are stolen once in a while but it’s a lot more rare, it’s not that much copper in them now that they are liquid cooled.
> we are all biased and reality is too complex to argue about without simplifications, so that's not a great argument.

However it's a good argument for distinguishing between simplifications introduced by feelings and the ones introduced by omission while trying impartial judgement, as these simplification premises would have different value to your listeners.

> Do you really think that a loss of that million is insignificant and that the roskosmos/rosatom/rostech/etc will accomplish more than all the people that have left? If so, could you explain why you think that?

We must first establish and agree on the dimension by which you're willing to evaluate that significance. What would be a unit of measurement of the significance that you're mentioning in your comments?
btw you can do italics on HN using asterisks like this.
In 1997, I bought a DVD player, and didn't have a VCR.

You couldn't rent DVDs at Blockbuster, or indeed anywhere. Most movies weren't available on DVD, so you could watch only the few that had made it to the format (and had to purchase them for full price, at that). Being a DVD-only owner was limiting and annoying in a bunch of ways, even though the DVD experience was a lot better than the VCR experience.

If in 1997, I had written a blog post about how having just a DVD player kinda sucks, and I want to have a "hybrid" VCR + DVD experience, it wouldn't have been a super hot take -- but at the same time, it would have also been clear that I wasn't saying there's any big problem with DVDs, I was just having normal early adopter problems, and pretty soon they'd all be solved. (By 1999, Blockbuster offered hundreds of DVDs for rental, pretty soon studios were cranking out their entire catalogs on DVD, and not long after that Netflix broke big.)

And... that's about where we are with EVs. If you have an EV today, you're an early adopter, and you're going to suffer early adopter pains. In 2-3 years, things'll be better. In five years, they'll be better yet. At some point, EVs will be so normal that only a few EV OGs will be like "man, remember when it was a whole big thing to find a working charger? Haha, wow, that sucked back then."
You have to remember that Apple struggled because developers weren't targeting their platform for a long time. The Mac was for creative software and little else. That problem has burnt itself into their psyche to such an extent that as far as they are concerned more software targeting their platform is always a good thing.

The upshot of this is Apple boasting about having 2 million apps in the App Store. This is the complete opposite of their normal product strategy where everything is pared back to the minimum.

Sadly you can't have 2 million apps and maintain a high standard. The costs to review each of those apps thoroughly would be astronomical.
Origins of Datura metel in Asia are mysterious for example
Maybe this guy did some social engineering at one time or another but the idea that he could get any employee at a Wall Street firm to spend an hour reciting the cell phone numbers of all their executives is a load of bullshit.
Jeff Bezos in that quote is talking about customer complaints and how they relate to SLOs.

When a customer is complaining about e.g. "your site being broken", there's usually some real problem they're complaining about (though whether it's your problem to solve, or their ISP, or their computer, or their lack of knowledge of how web browsers work, etc. is another question entirely.) But the point being, if your data says the customer can't possibly be experiencing an issue — i.e. if your data disagrees with the customer's own lived experience of having a problem at all, with the data saying that e.g. the customer made a successful purchase, when the customer says they couldn't even load the site — then that should suggest that your tools for measuring your data are broken, or that there's something else equally-fishy going on (like a Man-in-the-Middle.)

None of this applies to medicine/psychology, because medicine never has the sort of data that could even theoretically be used to make a claim like "this is 100% working, and anyone who says they have a problem is lying" — the sort of claim where even a single counterexample would be enough to refute that statement, and therefore where a single counterexample would be valuable.

Rather, the sort of claims made in medicine are Bayesian confidence claims. The sort of (evidenced) claim that gets a treatment approved by the FDA, goes something like: "treatment X tends to be well-tolerated in population Y, while producing a positive outcome of power Z with benefits outweighing the measured side-effects."

No single anecdote (= clinical data) refutes that kind of statement. Instead, you need to compile and quantify a bunch of them (= clinical data meta-analysis) to actually make an argument for or against that claim.

Knowing this, any attempt someone might make to wield a single anecdotal claim to influence the credence you give a statistically-derived Bayesian-confidence statement of the safety and efficacy of a medical treatment — especially where you don't have an intuitive sense for how much data went into the statistics that led to the original statistical claim — should be regarded as an attempt to manipulate you with rhetoric, rather than honest debate praxis.

Which is not to say that the anecdote is false! You can totally believe that the person's lived experience is real, and empathize with them, and try to come up with solutions for their problem; while also taking as hokum any attempt by them to convince you that their anecdote generalizes.
How about we just give up the very American concept of “road trip”? It’s bad for the environment, bad for your health, dangerous, and increases the burden on the already overloaded highway system. If you want to visit somewhere farther than your EV can take you, ride a bus, plane, or train. When you arrive, try walking, biking or ride-sharing apps to get around.
Psychedelic trips with mushrooms and with LSD are very similar, often you wouldn’t be able to tell them apart.

When there are visuals I find them to be more "organic" on mushrooms and more "sharp/electric" on LSD, but that’s very subjective/suggestible.

But there are "social" trips where there are no visuals, usually when in a group and experiencing the substance together, there I wouldn’t be able to tell LSD and Psylocybin apart.

The feeling of shared being part of a shared consciousness, the cosmic laughter and the fractal thoughts can be the same with both substances.

I'd say there is a psychedelic state of consciousness and many different substances (Psychedelics) will get you there, the experience will differ in nuances, but the general idea is the same.
Keep in mind that in this state you are highly suggestible, so the environment will often do a lot more to shape the experience than the exact substance.
I suspect the constant emphasis on mouse use, ever since the first Macintosh, has created an attitude of "keyboard doesn't matter"; I've noticed that even early Windows is very usable with only a keyboard (the Alt, underlined letters, and arrow keys method is particularly well-designed), whereas e.g. classic MacOS is basically unusable without a mouse.

In later versions they added keyboard access, but it still feels like it was done as a bare-minimum concession and not originally planned.
What's the ratio of those who left to those who graduated and stayed?
Also Nocebo effect!
No idea, I got them from a mushrooms shop in Amsterdam, this was about 15 years ago when they could still legally sell the actual shrooms.
>I think you misspelled “policy that reduces the debt burden of housing for those who can least afford to subsidize well-off others”?

No. I don't think he did.
LSD is not used in therapy for patients who have a family history (or individual history) of schizophrenia, bipolar, or schizoaffective disorders.
Not sure about that. A lot of us non-photographers do care about taking nice pictures and videos but don't really want to get into DSLRs because you never seem to have them around when you need them.

These days though most people don't care about more pixels, but better filters. There's still a ways to go before smartphone cameras get there. (imagine building in Moment-type lenses in smartphone cameras).
You have to renew the RHEL developer license yearly.

I'm way too lazy for that, so I tend to recommend the other options. The account is 100% worth access to their documentation though.

Also, RHEL changes. They have even rebased to a new GNOME release on a point release before.
You also gonna get bots as that was the intended purpose as it makes bot armies very expensive to keep, also to keep twitter afloat.
Which models are you speaking about specifically? Actually if I want to avoid the lower quality models, is there a list of Lego products sorted by year? I guess after year 2xxx they finally decided to cut corners and then feet, legs, etc.
I've had this exact same issue for the last year, Bing support have been useless. I'll do the same and write a blog post
Binary format is perfectly human readable. Anyone claiming otherwise hasn't seen an encrypted binary format.
I'm not sure you know much about the subject of which you speak.