skysight-inc/HackerNews huggingface dataset:
> xylazine currently has no antidote.

It's an alpha-2 adrenergic receptor agonist.

There are indications that alpha-2 antagonists can reverse or mitigate xylazine's effects.

Yohimbine, a very popular dietary supplement, is an alpha-2 antagonist. It reverses the sedative and cardiac effects of xylazine in animals [1], and should be quite well-tolerated in humans. It's also available in pure form via Amazon.com and millions of other places.

So it's not as though xylazine has no antidote in principle...

[1] - Spoerke, D. G., Hall, A. H., Grimes, M. J., Honea, B. N., & Rumack, B. H. (1986). Human overdose with the veterinary tranquilizer xylazine. The American Journal of Emergency Medicine, 4(3), 222–224. doi:10.1016/0735-6757(86)90070-7
Isn't breaking things down into steps always going to be a part of solving any problem? I think of how I was told to approach problems while developing software in this manner.

Maybe the LLM gets so smart that it doesn't need to do this, but that I would definitely want to call a super-intelligence, because I sure can't solve big problems without breaking them down into smaller parts.

But maybe you are on to something when you say there are some things that we've just done so much that we don't really have to think them through to accomplish them anymore.

I don't know what that would say about an AI that was smart enough it could just spit out the right answer to literally any question we could devise. That would be quite a feat of engineering.
Hmm I imagine there's a way to "freeze" neural nets into these types of systems to optimize them?
By legalizing most drugs and providing the supply legally they could simply put an end to a lot of problems. Drugs aren’t expensive to produce, they get expensive on the black market due to being illegal so the government wouldn’t even need to spend too much, probably a lot less than cleaning up this mess. Of course they should only allow addicts to get their daily fix in special centers so as to not allow these drugs freely on the streets.
You’re implying a reversal of the Norse of events. He was a daily meth user before he was in harm
Reduction.
I haven't worked at either... but I did work at a regional retail company.

Walmart is a massive logistics company that dwarfs any other - save maybe Amazon (and it would be interesting to see the break down side by side).

I believe it is dangerous to put the FAANG companies on such a pedestal.

Consider even McDonalds Tech Labs - which sold to IBM which was doing some rather interesting things with machine learning, and bilingual natural language processing (drive throughs).

My point is one of "Walmart to Google is likely much less of a jump than people imagine... other than the name attached."

https://en.wikipedia.org/wiki/Walmart_Labs
This is what I do. Also helps that I like the rest of the business. For me, this is mostly a win-win arrangement - I believe strongly in GitHub/Visual Studio/.NET/Azure/etc too.

If you dont believe in MSFT but want to invest in OpenAI, buying their stock is probably a terrible idea. You would be purchasing a gigantic liability (relative to your risk preferences) in hopes of gaining access to a miniscule component of the overall business.
I dont think people know many cool things you can do out of the box with text-generation-webui interface for chat models. With extensions for voice in/out, stable diffusion images in/out, long term memory and custom npc backstories its pretty much virtual reality in a box.

Just some examples of things you can do.

How about create a D&D (or any RPG) game, the NPC can be the dungeon master, creating monsters/loot and rendering pics in real time. Add additional NPC characters to join your party and actually take turns, you could play solo adventures. Even play via microphone, if the voice extension gets modified, you could have each character have its own voice via tts.

The extensions are opensource to make anything you want, connect it to web or any service. Have the npc chat avatars trigger on actions.

You can even train models, want to create a NPC based on a book? Feed it book series, tweak the personality, and you can chat with them, or make up new stories. The training model interface is included.

Or for adults you could even create a virtual partner, or any type of NPC/avatar you want. Have them text you stable diffusion pics, chat with you on sms. etc.

AND, the thing is, its out NOW on github with text-generation-webui. I was able to create a D&D dungeon master with stable diffusion in about 10 minutes. I did already have stable diffusion running thou, just enabled the api.

I can't wait to see how this new amazing software can take off to form new ideas, games, technology.
Defender's Quest is a little famous, though not enormously famous.
I always found it absurd that in a game where the player character is a street criminal and most of the game objectives involve robbery or murder, a minigame depicting clothed dry-humping is what pearl-clutchers found to be a step too far.
60 minutes wasting time on MTG just means you shouldn't watch 60 minutes, not that free speech needs to be abandoned.

Fox started the problem with our news, but now we have similiar outlets on both left and right doing it. Don't watch them.
In my case it was very implicit and it's only in retrospect after many years in other companies that I can realize it. To be clear, this was a textbook "growth & engagement" startup, but my experience nowadays suggests the same would apply in legacy, conventional companies too.

The firing itself was over a stupid misstep outside of my domain of expertise and also wasn't of any consequence to the business, which IMO means that it should outright be forgiven or at the very least downgraded to a formal warning considering I was otherwise on good standing (or at least I thought so).

The problem was that I was questioning and pushing back against a supposedly "technical" decision that even after 5 more years of expertise still feels correct - however by now I realized that the whole reason behind the decision wasn't a technical one but to farm out business to some high-up person's friends' company back in their home country. Tech-wise, this decision wouldn't have improved the supposedly-claimed problem (according to tickets and meetings) one bit.

The mistake I did was just a convenient excuse for a firing, but overall it worked out both ways - they eventually got a lucky exit (and I'm sure whoever was involved in that scheme also benefited even earlier regardless of the exit), and I got to learn a decent lesson about office politics to carry with me in my freelancing career (I didn't have any stock options or any good money on the line anyway, so no hard feelings and I still got a good reference).
Maybe an old mechanical clock would also be a great thing to take apart (and perhaps put together again :))?
How about a C-2 based gunship. Carrier launchable so Navy could buy.
Guess we better abundantly optimize for those corner cases until all speech is illegal.
There’s no need to build the right tech on their own. They can simply miss some tech and find a close enough FOSS or build a close enough version.

Where “close enough” means build 80% with 20% effort. Or even 20% solution with a day of effort. Whatever makes sense in the new environment (which doesn’t need to scale to billion active users, for example)
Is the convenience store responsible for customers getting smoking related illnesses? Or the grocery store if some flour they stock has salmonella?
That’s the point of harm reduction. If we stop focusing on treating those with drug addictions as criminals, they can potentially contribute to our society instead of having their lives destroyed by criminal convictions and medical issues from unsafe drug usage. Instead of being further cast out of society they can live with some level of dignity even if they cannot overcome their addiction.
the current bishop of Rome indeed sees it like that, a little bit. he even sees bishops as some among many important Catholics
https://www.synod.va

wrt free speech I find poppers paradox of intolerance relevant. a unhealthy overdose of Der Stürmer and lashing out against some scapegoat minorities lead Europe into WWII

in simple words: you _have_ to put limits on bullshitting else your freedom is shat on.
I’ve got 2 rtx 4090s on an EATX motherboard. Been using them to run the full 13B un-quantized with a good deal of success. Getting about 20 tokens/s.
I was rather like that as a kid. Meccano, Fisher Teknik are both good because you can build a wide range of rather complicated "creations". Old clocks are good because the pieces are rather large and ideally can be re-assembled and made to work again as well.

Around that age I was given a motorcycle battery and a variety of bulbs, relays and car parts. Unfortunately these days, electronics and miniaturization has reduced the scope of what can be educationally taken apart.
people said the same in 2016, 2020, 2012, etc.

Bigger tech companies and winner-take-all markets means bigger salaries and more perks to attract top talent when the stakes are so high. The next big arms race is AI. You can be sure tech companies are offering huge salaries for top talent there too.
Only if you're drawing meaning from the fact that people believe their own stereotypes. "Left-wing students fell for parody written by other left-wing students" does not constitute evidence of the truth of the stereotypes contained in the parody.
The Anglo West's approach to drugs has absolutely failed. Rehab the abusers, lock up and punish the dealers (some countries use the death penalty to strong results), and secure your borders properly.

Instead, we get kvetching and hand-wringing about "what can be done", and tittering discussions on online message boards, while society decays even further.
Stanford benchmarks and compares numerous Large Language Models
Interesting tidbits

- Not all these models are instruct aligned

- Cohere's suite is free for personal use

- anthropic uses reinforcement learning from ai feedback for instruct alignment, removing humans from the process almost entirely(humans still make the rules the language model checks the responses against).

- open ai's models are pretty poorly calibrated compared to its peers. Calibration is how well the model's confidence solving a problem tracks with how it actually performs that problem. It seems to be a consequence of the way they are performing the instruct tuning (or maybe it's a consequence of instruct tuning in general).
The gpt-4 report actually shows this. Base gpt-4 was excellently calibrated but rlhf knocked it right out.
The excellent calibration was also independently verified (in the medical domain) from the paper about gpt-4's medical prowess. https://arxiv.org/abs/2303.13375
I’m coming up on a year of my post layoff sabbatical and there’s no world where I go back to corporate America - which to be clear is any tech company also.

It’s so obviously bad for society to be the high risk exploratory appendages of the financial markets. Make no mistake Venture Backed “Tech” and “startups” are the means through which capital accretes value.

While I’m on the extreme end, I’m hearing echoes of this from others who at the senior level who have been in tech for a few rounds as engineers.
Some people can move FTL, some people can't.

The time coordinate increases with causality. (Same as in Newtonian physics.)

If you want SR to hold, then yes, information teleports.

If you want to travel FTL, then SR can't hold obviously.
> a drug that literally turns you into a melting, oozing zombie with flesh dripping off your bones

Reminds me of Krokodil [1].

That said, I just finished listening to an episode of Radiolab [2] describing how unsubstantiated claims about fentanyl causing overdoses through contact may have triggered episodes of mass psychogenic illness [3]. So I'm inclined to take these gory images with a grain of salt, e.g. these may be a wounds that were neglected due to drug use versus unavoidably caused by it.

[1] https://en.wikipedia.org/wiki/Desomorphine#Toxicity_of_kroko...

[2] https://radiolab.org/podcast/good-samaritan

[3] https://en.wikipedia.org/wiki/Desomorphine#Toxicity_of_kroko...
I think they meant job stability not system stability.
Very nice, this can be used to build a cool motd :)

Not about this project specifically, but there seems to be a general trend towards TUIs.
As someone currently working on a native GTK+ app, the state of native deskop UIs is horrible. GTK+ with all the depreciations? Painful. Win32? Oh god. UWP? Please, no. UIKit or Swift? Desktop software is no longer important enough to support multiple platforms natively...

I feel like we are headed towards a split between Electron for end user applications and TUI for portable tools. They even run on servers and modern terminals on any platform can "render" the UI!
No, actually. There is no slippery slope that inevitably leads to all speech being illegal.

Instead, the court system in the USA mostly does a pretty good job determining what is or is not speech, and ways of having very limited restricts on speech that only prevent the extremely harmful stuff, while maintaining people's rights.

Addressing these "corner cases" is exactly what the court system does, and it has resulted in a society where the vast vast majority of speech is protected, and only very extreme and damaging edge cases are banned.
Hello fellow Generals fan! Truly an amazing game, the gameplay videos of the unreleased Generals 2 game make me really sad.
I found it surprising too, on the basis of, it could pose perceived or actual conflicts of interest in their work. And of course the performance and/or liability risk on the org.

But you skipped the part of the quote where he's been abusing drugs since age 11 - it'd certainly be more alarming if he was sober but after working at the clinic for a bit, started taking up IV meth. But yes, still surprising, however there are benefits to serving the people that you can relate most to.
Without previous experience of what kind of high strong opioids (or other heavy drugs) gives you, it's hard to imagine people taking the risks of using them. But some of them really are that fucked up on your psyche, that you'll do anything to continue using them after you've used them for just a short while. It's really easy to get addicted and really hard to get out of there.
Paper pretty much confirms that calorie differential is what matters the most when it comes to weight loss.

I think it'll be interesting to see the results (especially in terms of compliance) when you also add timing of eating (IF) and source of nutrients.
Lenovo T14 gives me about 12h. However that's with the much faster CPU.
7,300 deaths per year in canada from opioids.

48,000 deaths per year in canada from tobacco.

One is legal to sell on every street corner. The other is a crisis.
The policy has (so far) been the opposite, try to punish drug use as much as possible, intervene with police and go after every small time drug dealer between heaven and hell.

It doesn't seem to be working. What if we try the opposite instead?
Freedom of speech, as a political right, is fundamentally a right to protest. It's about the ability to speak against those in power without excessive consequences.

When you have some students against a high-level public official, the students' rights are obviously more important from a freedom of speech perspective.

Of course, freedom of speech is not an absolute right, and it's not the only thing that matters. If the university finds it valuable to host controversial speakers, maintaining the order by suppressing the freedom of speech of those who try to disrupt the talk can be a valid choice.
second link should be https://radiolab.org/podcast/good-samaritan
I would not be surprised if US FedNow uses it now or later in their offering, launching this year.

I wish you hadn't spent so much time fighting a straw man in my place, we might have been able to talk any sort of tech.
Also please note, that either relativity or quantum (or both) is total wrong.

None of the laws and equations hold quantitatively, also the basic objects do not exist, and the basic axioms don't hold either. All of the qualitative results, conservation laws, negative laws that forbid things are total useless.

There is a chance that relativity is wrong, there is no spacetime, there are no frames, E, m and c are useless numbers, and albeit they are definable and measurable, E=mc^2 never ever holds. (< or > holds instead)

Or the same can happen with quantum, there are no states, you can't add states together, Dirac equation never ever holds quantitatively, etc etc.
> I think that person is suicidal.

Important to remember that the alternative to shooting up is, often, to be cold, and miserable, alone, on the street, with no sleep.

One possibility potentiates the other.

Horrifically, you could even think of drug use as an attempt to adapt to loss of housing.

The backdrop for urban drug use, here in Vancouver, is a profound housing crisis and shortage, and a complete, thoroughgoing failure on the part of multiple levels of government to do anything about it.
So what you're saying is you have a lot of work to do = job security ;)
I know it's highly unpopular thing to say but A10's are also failing at their own role.

Its main gun cannot achieve penetration against modern armor and their armor cannot survive against modern AA.
String theory is not astrophysics but particle physics.
People who can’t draw this fish might have brain damage
Singapore offers another approach that seems to work ok. Probably the real lesson is that half assed measures don't work. And you have to go all the way. No matter the direction.
I used VMS in the late 70s and early 80s. I started using Unix too, in the late 80s. What was wonderful about VMS at that time, relative to Unix, was that DEC sold a large set of books, the "pumpkin books", which explained everything you needed to know to do just about anything with the systems (there was also an "internals" book). In contrast, at that time, if you wanted to learn to do something difficult in Unix, you essentially had to go find a Grey Beard to tell you how to do it. The internet and Linux changed all that of course, but before that happened learning VMS was a joy and learning Unix was a pain.
Thank you–fixed.
A proposal for upgrading these “safe use sites” (if we’re going to have them, might as well have good ones):

The use site has a (24/7 guarded) attached pharmacy with government-produced clean heroin, meth, etc. Users can trade in their drug, the pharmacist runs it through a mass spec analyzer and dispenses back to them an amount of pharmaceutical-grade drug of interest, the amount dispensed being equal to the fraction that is present in whatever cut/mixed drug sample they handed in.

In addition to the obvious safety benefits of only consuming guaranteed-pure drugs, the drug user gets an on-the-spot and very salient piece of information about the quality of the drug they purchased. This creates a lot of precise and accurate drug quality information and feeds it back into the drug abuse cycle. A user buys from a dealer, and right before their first hit they get a purity score to evaluate their dealer with - and maybe some information about what other drugs their dealer just tried to poison them with.

(To avoid some obvious risks: the tested drug sample should be immediately ejected from the analyzer into a denaturing bath and regularly incinerated, so that handed-in drugs are not a theft or recycling target. You probably need to mandate they can trade in only the dose they are about take, and they have to take it on the spot, so that government supplies do not leak back into the streets. There are certainly other failure modes too, a close eye should be kept on this and further processes brought in as needed.)
Managers be managers, no matter if it's in retail, software or warehouses, no matter if it's Apple, Toy'r'Us or whatever. If they have something they consider an emergency and have your personal phone number, it's not super uncommon to be contacted by your boss outside of regular working hours. Repeating what last commentator said, not every boss is like this, obviously. But if you ask around in your circles (outside of software), then you'll see it's not super uncommon either.
> That said, there is still an appetite for talent at well-funded, early-stage companies in emerging areas, including electric-vehicle batteries, as the auto industry shifts away from gas-powered cars, and artificial intelligence, a technology with the potential to change industries that has prompted a global race to build AI products.

My Wellfound (previously AngelList) inbox begs to differ!
Getting deported OR settling for first acceptance jobs within 60 days. OR going to Canada that has opportunistically opened their doors. OR going back home.
> legalizing it and providing the supply legally they could simply put an end to a lot of problems

To underscore this, the reason we have a heroin epidemic is because our solution to the preceding prescription opioid epidemic was to take away the pills.
it's perpetuated because it makes a lot of people a lot of money. both on the criminal side and the law enforcement side.

plus now you can just blame china for everything. it's super convenient and lucrative!
Haxe's double-edged sword that it lets you approach cross-platform in an uncompromising fashion where you're really getting as close to the target as reasonably possible, while also abstracting away as much of it as possible, but it also directly exposes you to the high level of engineering effort necessary to achieve that.

A lot of what I encountered from my time using it(which I might return to someday) was that it became more irritating as you introduced more platform dependencies, but mostly because it became harder to build the project. And this was disproportionately true for targets with complex build processes(SWF was one of them back in the day, and C++ still is).

Some of it does get mitigated by doing a double layer of abstraction: your platform code has a shell of functionality that is handled using the native paradigms, but exposes an interface that Haxe code calls. And the Haxe code accesses your own abstractions, not the native ones.

But doing all of that can get away from "just getting a result", because then you're pushing more of the development onto the native target. If you don't have a clear view of what abstraction you want, you can get stuck on designing it.
Except particle physics - which I guess is why they are trying to sell it this way.
The problem with using a regex as you describe is that GPT isn't working at the level of words, its working at a level of meaning and intent. You can have it translate rather meaningfully between metaphors that exist in completely different contexts.

Somewhere in the 90+ levels of interconnected neurons, the literal meanings are abstracted and re-encoded. A regex isn't going to accomplish that.

edit: you might be able to match this little tiny GPT, but not one of the billions-of-parameters varieties.
No but they must remove/stop selling the affected product. The vendor does a full recall ofc.