skysight-inc/HackerNews huggingface dataset:
Paper: https://pubmed.ncbi.nlm.nih.gov/36897988/

Abstract: The Siglecs (sialic acid-binding immunoglobulin-like lectins) are glycoimmune checkpoint receptors that suppress immune cell activation upon engagement of cognate sialoglycan ligands. The cellular drivers underlying Siglec ligand production on cancer cells are poorly understood. We find the MYC oncogene causally regulates Siglec ligand production to enable tumor immune evasion. A combination of glycomics and RNA-sequencing of mouse tumors revealed the MYC oncogene controls expression of the sialyltransferase St6galnac4 and induces a glycan known as disialyl-T. Using in vivo models and primary human leukemias, we find that disialyl-T functions as a "don't eat me" signal by engaging macrophage Siglec-E in mice or the human ortholog Siglec-7, thereby preventing cancer cell clearance. Combined high expression of MYC and ST6GALNAC4 identifies patients with high-risk cancers and reduced tumor myeloid infiltration. MYC therefore regulates glycosylation to enable tumor immune evasion. We conclude that disialyl-T is a glycoimmune checkpoint ligand. Thus, disialyl-T is a candidate for antibody-based checkpoint blockade, and the disialyl-T synthase ST6GALNAC4 is a potential enzyme target for small molecule-mediated immune therapy.
Ding ding ding. It sounds like everyone knew the grift, but didn’t care because they got paid.

Meanwhile they’re profiting off some 13 year old getting raped in a Motel 6.

Not that great!
What do you look for in a tech/developer podcast?
I'm mostly thinking database-related but am open to other development realms.

Mainly, what attracts you to a programming podcast and keeps your attention? (Or loses it?)
I always think of FGPAs for things you want to update without having to repurchase the hardware. If the FPGA inside a gadget can be reprogrammed over the Internet then I think it's more suited than an ASIC for LLMs.
The school should match your future life. If you expect your kids to be sheltered for the rest of their lives, go ahead and homeschool.
I mean is this not revolutionary? It seems pretty revolutionary.
I don't know what they had in mind, but I'm guessing something like "we need to refactor/restructure our code, it's a mess right now" might fall into that bucket.
I’m pretty sure your query will effectively still be derivable on the server side, as it has to syntactically/semantically interact with the model. To truly disguise it, at least part of the model/weights would have to be transferred to the client side (so that the server doesn’t learn the adjustment), which would in turn leak the model.
I would complete the description by mentioning that the one employee that was helped probably had to return whatever help was given as it was just for TV.

They can keep their 20% discount though on the after-work course "5 ways to financial success" so that personal issues stop disrupting productivity.
wanted to correct this one: I confused Barbados with Jamaica here. Barbados is a republic. I am sure its laws still use the term "the crown", but it looks like it uses the term "Public Prosecutor" instead of "Crown Prosecutor".
South Park has picked up on ChatGPT
The internet was mostly over in 2001. Of all the parts we really only kept the web, and even that is just a shell for ads now.
How about Congress do it? They could wrap it into an inclusive worker and consumer rights bill that bans a laundry list of predatory practices.
Yes- to your edit. I was just on phone talking to my older brother, and I mentioned that I had commented on this thread. I told him that while I played with explosives and such, I was always very cautious about it. I never tried to make nitroglycerin as I did not think the fun was worth the risk. He said he was glad I grew out of that phase. I told him no, I still enjoy chemistry and physics, I just don't have the time to play.
Ja Morant is currently throwing his life away because of the enormous pressure to do this. He’s from a nice family and is definitely no gangster.
It's also a really bold claim that he doesn't back up, so I don't trust the rest. It's not like he dug around and found out that the main protobuf author was actually some hack who forced something bad on the rest of the company then bailed. That would be Google Plus.
I didn't realize underage drinking was part of the conservative party platform.
Imagine if over the last few centuries they had developed techniques for making people think and believe things.

Phew!
And their identity and whereabouts remains concealed - which I believe is the more relevant factor here.
I see this time and again and people need to know that bleach is not a cleaner. It is a disinfectant at most and an oxidizer that can turn some things white but, no, it does no cleaning of its own.
> the university hired outside lawyers to step in

Cynically I think that the university spending lots on billable hours makes these types of investigations more likely to continue and grow.

It seems like universities having infinite money through their endowments lets them fund stupid projects like these investigations and a near 1:1 student to admin ratio.

This seems like something like alumni and benefactors can help by requiring some governance of this stupid pork. Or maybe federal funds will not pay for orgs that spend more on admin than teaching or research.
That's definitely an aspect I never got.

Cutting edge ASICs production, and their associated supply chains, are in fact even more centralized then the Federal Reserves + 9 next largest central banks.

And a chain is only as strong as its weakest link.
I think this is wrong because you can always build a search engine - it’s not hard - and you can supplement the learned models with cryptographically secured private data to build a private personalized model. In fact this seems in all ways superior to any alternative, and strikes at the heart of the Google spy ware ad spam business model.

And seriously, did you really try to assert the Google whatever it is has outperformed Siri? I’d love to meet someone that uses it so I can verify this statement. But with the advent of Chatgpt Alexa, Siri, and Google whatever all look like freshman projects. The next generation of assistants have just begun, and I assure you, the state of the past has nothing to do with what comes next. OpenAI hit a giant reset button across an awful lot of stuff.
I've seen tweets that suggest they are using it, particularly, the prerelease GPT-4 was used internally.
Awesome! The e75 looks like it should be feasible. I've just reached out.
Just keep in mind that SSR in Angular is a bit more painful than in other libraries. It's also quite bloated in both development and production. Other than that I quite like it. RxJS takes some time to learn but pays off well.

If you're ok with learning something with less adoption but similar batteries-included feel I'd recommend learning SvelteKit. I see it do a lot of things that Angular does well without failing were it's bad (i.e. breaking changes every six months).
Coalton: How to Have Our (Typed) Cake and (Safely) Eat It Too
A problem with this is why one's heuristic should tend toward magic from mythology.

When you encounter unknowns and feel compelled to fill in the blank, why should you reach towards "souls"/"god" than towards more prosaic things like physics and computation?

The answer is obvious: you shouldn't because there's a solid track record of magical memes being fictional.

(Also, imo, if you can't define concepts like consciousness, that might be a clue that they don't exist either. Or, at the very least, you're not communicating anything meaningful when using those concepts even if you feel like you are.)
Maybe I'm wrong, but a misdemeanor (or a meeting between the students if acceptable to both, except apparently it was an administrator and not the coffee-dampened football player who filed the complaint) might have been preferable to a 5-page single-spaced letter threatening a final-semester senior with expulsion.

"Where'd you go to school?" "7 semesters at Stanford, finishing as captain of the women's soccer team, then they expelled me a month before graduation for throwing coffee on someone who'd sexually assaulted one of my teammates."

Yeah, I'm pretty sure misdemeanor charges with a fine and maybe community service would've been preferable to threats of expulsion from VERY EXPENSIVE school you were about to graduate from. All the time, all the money, all the student loans, but no degree.

Good thing Stanford apparently makes its money on research. What are the odds ANY of the women on the soccer team she was captain of ever give money to the school as alums?
IPCC 2023 climate change report (abridged version) [pdf]
Tesla opens more Superchargers in Europe for 3rd party use
Talk about burying the lede, the article is 4000 words deep before they mention that the draconian party requirements were implemented after an unconscious student was raped behind a dumpster at a frat party in 2015.
That is a really interesting idea and something we'll explore.
ok, we could/should easily cut half of them as well. Have you ever looked at how wasteful our military spending is?
They do have a search engine though with Siri Suggestions. Which has a user base of ~1.5b+ people.

We only see the tip of the iceberg so who knows what else it is capable of.
Hashrate doesn't matter if nodes don't accept their blocks. So while you're right that a powerful government could severely strike Bitcoin by taking down miners, they can't force the community to accept invalid blocks, no matter how much hash power they could amass.
If you need a framework: NextJS (no, don't suggest Remix, every single good feature about it has been copied by every library and their grandpas)

If you only need a bundler: Vite

If you want to be happy: Don't.
Can you give an example of what keys you mean by this?
Interesting how the Expedia plugin attempts to guide the GPT response with the use of
an EXTRA_INFORMATION_TO_ASSISTANT text field in the json response which implores the model to, among other things, "NEVER mention companies other than Expedia"!

https://twitter.com/wskish/status/1639052575579471877
How’d GPT-3/3.5-turbo do?
It is - free trial with automatic rollover is set up anticipating that people will forget to cancel. It is not being offered as a good faith service.

Inherently if you are relying on something to thwart or subvert the intention of the person you are dealing with you are engaging in duplicitous behavior.
It also sounds rooted in Epictetus, the Greek Stoic. Interestingly, Christian monastics used the Enchiridion of Epictetus to guide their intentional communities.
You would need nuclear chlorine :). Neither chlorine, water, nor ammonia contain carbon, so they can’t react to form anything containing carbon.

Chlorine reacts with ammonia to form monochloramine, which is fairly innocuous. Monochloramine reacts with more chlorine to form dichloramine and nitrogen trichloride, which are stinky and potentially dangerous.
tweet #2 in the thread was missing, wonder what happened there?
Probably not that you'd understand very well
Most people tend to over estimate how talented the average non professional writer is and dramatically under estimate how good pro writers are. Writing is very hard. The issue is not coming up with ideas either, so don't think gptX streamlining the hard work (actual writing) will make much of a difference either.

Same is true for acting, photography, directing, etc.
People didn't like him.....and had a way, due to belief, to punish him
Fortum explores hydrogen at airports with ZeroAvia
The Well-Poisoning Machine
Small suggestion: You may want to fix your DNS configuration which currently only resolves readlang.com and not www.readlang.com. This might confuse some visitors (it confused me when I typed readlang and pressed Ctrl+Enter):

~ $ dig a www.readlang.com

; <<>> DiG 9.10.6 <<>> a www.readlang.com
;; global options: +cmd
;; Got answer:
;; ->>HEADER<<- opcode: QUERY, status: NXDOMAIN, id: 65131
;; flags: qr rd ra; QUERY: 1, ANSWER: 0, AUTHORITY: 0, ADDITIONAL: 1

;; OPT PSEUDOSECTION:
; EDNS: version: 0, flags:; udp: 1280
;; QUESTION SECTION:
;www.readlang.com. IN A

;; Query time: 62 msec
;; SERVER: 2406:3400:41e:5a80::1#53(2406:3400:41e:5a80::1)
;; WHEN: Fri Mar 24 10:06:36 AEST 2023
;; MSG SIZE rcvd: 45
The frontend web framework landscape is pretty complicated and fragmented, sure, but is it really any different from backend?

Take a look at Amazon’s or Google’s enormous list of cloud products and tell me your eyes don’t glaze over. And that’s not even the full ecosystem, it’s just the products directly supported by one company!
I invite everyone to try this new Linux distro inspired by Slax and Porteus, with the main goal of being super fast, small, portable, modular and immutable (if the user wants so).
> They are adults, and if there are no reasonable venues for being able to do regular adult things, for intentional reasons or not, they will create venues somehow, someway.

Yes, it's called an off-campus apartment. Students have been drinking in them for centuries.

America's pathologies around student drinking are ridiculous. But let's not pretend like the path of least resistance doesn't already exist, and isn't in wide application by just about every other college in this country. The only reason we're talking about Stanford is because it hits all of the culture war hot-topic buttons (elite college, bureaucracy, "coddling," &c.). Nothing about the actual state of affairs is remotely unusual or controversial.
> To be clear, this doesn't void the contract you have with them, you're simply revoking their privilege to charge your payment method.

It's gotten better, but on more than one occasion I've had to argue with my bank to honor my request to block the charges. I've had tellers say "Well, if you have a subscription with them, this needs to be allowed". No. As you say - my bank's obligation is to honor my account wishes, not be an arbiter of my agreements with third parties.
> In the future state, your AI will simply give you the answers directly. You won't email me and you don't need me.

that sounds great. you emailing me about a project and waiting for me to write an email to you is an inefficient waste of both of our time, and if AI can give us that time back, it should.

> My point is that many if not all digital interactions become pointless.

but I disagree that it will render all digital interactions pointless - just the day to day drudgery.

20 years ago, if you wanted to find out the opening times of a store you had to call them up or walk to the door. now, you can google it in seconds. we have done away with a lot of the short phone conversations, and our lives are better for it. but we still talk on the phone. the conversations are more meaningful and less redundant.
The Secret Joke at the Heart of the Harvard Affirmative-Action Case
The US Government is $30 Trillion (with T) dollars in debt because they literally can't spend less than they bring in.

Trying to compare that to any company is absurd.
Because Elm is functionally dead. Core libraries? Not updated for 2 years. Core compiler? Not updated for 7 months. It's only Evan, who is seemingly burnt out, and hasn't handed over progress to anyone else. A quick glance into the Elm community will surface this. Feel free to nerd out on an esoteric approach but all the other products coming out are generally shipping fast and bouncing approaches off each other using Next.
Haha you're right, but as I always say, Latam, despite becoming red all over, is too corrupt/poor/unstable/inept to pull anything off.
There are talks of a single currency ("Sur") which will never happen because Brasil doesn't want to hold Argentina's bags, because there's always been a grudge among many of these countries.

Furthermore, there's a philosophy here: many rules, barely any enforcement (because of reasons stated above).

Ultimately I believe that the EU does have the capacity to do what they say. That's whats scary. Mercosur, not so much.
SVB's Loan Book
Very interesting walk-through showing the sort of credit SVB was providing startups.
However, there was enough of an outcrying by the community and my experts that it was pulled. Therefore end users do care about privacy when they understand the implications.

After all, it's hard to care when you don't have power as an end user too act on those feelings.
Socrates did not originate the word, his usage is the most famous we have historically available.

The Greeks believed in good spirits helping people ("Eudaemon") and evil spirits for darker purposes ("cacodaemon")[1]. It was believed that people had these spirits helping or harming them as the case may be.

The same goes for "genius", a spirit from whom we get the words genie as well as "Djinn". The common usage was that (quoted by Elizabeth Gilbert) a great person "had a genius", as in, a spirit helping them, as opposed to "is a genius", which is a later usage.

[1] https://en.wikipedia.org/wiki/Cacodemon
this is also the origin of the "Cacodemon" in Doom.
The real reason is here: https://www.opensecrets.org/orgs/block-inc/summary?id=D00007...

Why would you fuck with the DNC’s golden goose?
> And seriously, did you really try to assert the Google whatever it is has outperformed Siri?

Anything outperforms Siri. Google Assistant is head and shoulders above Alexa and Siri.
lead metal is safer than tungsten to have in your body

https://pubmed.ncbi.nlm.nih.gov/29300000/

don't confuse government power with wisdom; in many ways they are opposites
It doesn't work well at all. (Also alpaca.cpp uses 8GB of RAM for a 4GB model, possibly because they don't know how mmap works.)
Risks to physical danger evolve all the time. It’s not a big leap from AI generated this script to a fatal bug is nefariously hidden in the AI generated library in-use by mission critical services (e.g. cars, medical devices, missiles, fertilizers).
https://archive.is/GBdPm
Ask HN: 1Password passkeys don't require authentication
I'm a little confused how 1Password's demo is registering a passkey without asking for authentication (like Yubikey or Touch ID).

For context, 1Password recently announced they were trying to support passkeys for password-less login and created a demo site for users to create passkeys with 1Password: https://www.future.1password.com/passkeys/

I'm a Mac user, using chrome, and I was trying out the demo and I'm really confused how they are able to register a passkey with the user without making an authentication request for the user (like Touch ID, Yubikey, etc.). In the demo, when you authenticate, an overlay appears in the top right hand corner and registers you in automatically if you have the 1Password extension on your computer.

Additionally when I navigate to my chrome passkeys, (chrome://settings/passkeys), none are registered there with the rpId of the demo website.

For safety / security reasons, I'd like to better understand how they're stored if they're not stored on the device's secure environment. If anyone has any insights on this would really appreciate it.
I would not say they are the best chips if you want to run locally. They are ok although a bit slow compared to desktop gpus for inference.
It continually amazes how advanced yet also how backwards the US is.
We could also argue whether teaching about the "benefits" of dog eating would have negative effects. The goal of such "educators" is to uproot the morals early and normalize the abnormal things.
Just use Next.js? If you just use it by following the getting started and don't use their SSR features if you don't want them, it will Just Work™

I really don't understand why the outcry even exists. It's recommended for a reason and whining about how SPAs still exists misses that no one ever said that it doesn't. The only thing people are mad about is that Vite didn't make the list but that's understandable because I could never tell the new React developers we just hired to do this project by themselves with Vite. But with Next.js (or whatever else on the list) it was a matter of "File here, this URL, your React component here. Don't think about SSR I'll take care of it if we need it."

And it just works. Even too good because they run into issues so rarely that I forget that they make so much progress and we're already on our 3rd project with it. And they literally started coding 5 months ago.

And if you care about what's going on under the hood, guess what? You're one Bing chat away from finding Vite and a few commands to have it running locally. Want SSR now too? Guess again, you are already setup to do exactly that in a way more ergonomic way than the low level Vite plugin (which I like, but I would never be able to hand-off to other developers)
> It removes a sense of artificial precision that doesn’t really exist because weather forecasts fundamentally have very high uncertainty and error bands.

While this is true on the multi-day range for sure, what really made Dark Sky magical was its to-the-minute prediction of rain.

If Dark Sky said "rain in 22 minutes", you had 18-26 minutes to walk a dog before getting wet.

No other weather app has ever come close to that.
Or maybe, just maybe, Xanadu wasn't as great idea as he thinks.
you're conflating work and, uh, "activity", so you're just talking past the OP instead of understanding them.

a common usage definition of work being used here is in terms of creating "use value". the ceo's activities do not. they do generate profit for ownership though. which is not the same thing as "use value" and serves a different purpose in society.

this is basic analysis, not a judgment.
“Hey siri, what is today’s date?”

“Sorry, I’m having trouble connecting to the network”
Considering the date, do we take this seriously? Hopefully it's folly
The esbuild diagram is quite misleading because Vite does not only use esbuild, but also rollup and postcss.

Webpack can be set up with esbuild and will be equally fast, while being more flexible to configure, especially regarding multiple CSS entry points, which to my knowledge is not possible with Vite.
This comment section is 99% preconceived biases and notions about homeschooling and nothing to do with the article.

Can dang or someone just preemptively run the article through a "pro" / "con" ChatGPT prompt on the overall topic and then delete comments not directly related to the article.

To avoid hypocrisy: this is a ridiculous amount of money to spend on books and crafts a month. Do they not have libraries?
Would WebForms work?

https://learn.microsoft.com/en-us/aspnet/web-forms/what-is-w...
Deprecating a field in the struct becomes difficult then without versioning.

And versioning only works when someone remembers to increment the version.
I have a camp 4: viewing coding as a roadblock. A necessary obstacle to achieving some result. This is how companies view programming. They don't know about it, don't care about it, they just know they have to do a lot of it to produce their next product.
Looks like 81.6%.

macrolocal linked this below: https://paperswithcode.com/sota/common-sense-reasoning-on-wi...
I wonder if this is (at least in part) just process-is-the-punishment.
No. The trees are owned by the Dutch company and they don't have a license to sell there. The customers of the end product are all in western Europe.
HN discussions:

https://news.ycombinator.com/item?id=35207787

https://news.ycombinator.com/item?id=35208721

https://news.ycombinator.com/item?id=35249971

https://news.ycombinator.com/item?id=35273305
Chatbot-tuned models must have a "theory of mind", because they're able to tell which parts of the chat history are theirs and which are yours.

(This doesn't use tokens. You can have a conversation in OpenAI Playground with text-davinci-003 and provide all the text yourself.)