skysight-inc/HackerNews huggingface dataset:
No, the fact that amyloid-beta or at least its precursor protein APP is causative in Alzheimer's disease is based on very solid science, with a huge amount of genetic evidence behind it.

Lecanemab an antibody that binds to amyloid-beta, is disease-modifying and slows down cognitive deterioration.

The paper from 2006 carried no significance for any of this and it had only minor impact on Alzheimer's disease research.

There has been discussion to whether the plaques of amyloid-beta protein are disease-causing or not. I, as probably most others, believe the plaques as such are non-causative, and that the damage from amyloid-beta happens when amyloid-beta is in a soluble state.
These sorts of strong armed solutions are likely to be the only sorts of solutions that work in the face of 21st century scope of problems. The old model of nudging and designing incentives is not going to be strong enough in the face of the massive existential problems we face. Sadly our democracies are showing their fundamental weaknesses in these situations.
I cried a little when I read this :(
And abbreviations. Most Brits know NFN - Normal For Norfolk. There's some hilarious ones.

While I can see the offensive side and this sort of thing is likely going to be assigned to history eventually I suspect there's some value in many. Sometimes if someone's CTD (circling the drain) it may be valuable for the next clinician to understand that, in a way that makes light of what I'd imagine must be fairly depressing to deal with on a routine basis.

I suspect the physio doesn't write that phrase for every patient, there was probably a reason, one not to get too out of shape over.
I just switched from Edge to Ungoogled Chromium for exactly these reasons. It used to be a slick, lightweight alternative to Google Chrome, but the last 6 months or so have been a disaster, and the beta version is even worse with the useless sidebar that magically appears when you accidentally hover your mouse in the corner and the hideous rounded corners that turn your Surface Pro into a 1950s CRT. Not to mention the default search one day decided to railroad me into using mainland China censored Bing instead of the international version. It's been so disappointing.

Meanwhile on Android they also started screwing everything up, which led me to switch from Outlook and Edge to k9 and Bromite.

I don't know what's going on in the applications teams at Microsoft, but it's really soured me on the "new" Microsoft, and I've been a fan up until relatively recently too. I just hope VS Code isn't next.
What if the "so on" is infinite?
I've wondered if my kids will literally kill me through sleep deprivation.
A Short History of Berkeley RISC
"dark" as in the tech term "dark pattern." User-hostile defaults are generally considered a dark pattern.
So, it sounds like they proved that, if given absolutely no other information by which to judge others, and needing to join up in a group with absolutely nothing at stake, they join up with people of similar attractiveness. Which, you know, sure, but that doesn't really seem like it tells us much.

If they had to join together in small groups to perform some task together, it might have been a little more interesting. It also would have been more interesting if we had been given some measure of the correlation between the rated attractiveness and the propensity to join the same group.

I mean, for all we know, this could just mean that the people doing the attractiveness ratings gave anyone non-Anglo a low score, and that the students tended to join up more often than not with members of the same race. Or, they tended to rate women as more attractive than men, and the students tended to clump up in same-sex groups. I'm not saying that's what actually happened, but you can't tell from this article.
This is an era where "what you listen to" is entirely a personal choice, no 2 groups of people hear the exact same set of songs unless they want to. Same goes for movies, TV, any consumed media really.
"Turn site into desktop app" is a Chrome feature, and has been for many years. Chrome calls it "Create shortcut - Open as window".

Website translations and the profiles UI is very similar to Chrome as well.
> native toolkits

I get them, but I'm just not interested anymore with 3 desktop and 2 mobile platforms to think about. Sure it makes sense sometimes, but this should be fun.
Unrelated but fascinating: I have recently seen a group of people who acquired a 50 lb tungsten cube. At first it seems like a weird thing to spend a few thousand dollars to have but then everyone who interacts with it is fascinated by it, even describing the experience as life changing. Example: https://www.tiktok.com/t/ZTR7gry3o/ and https://www.tiktok.com/t/ZTR7gJ3VB/
0 effects on what? For whose benefit is this simulation? The thought experiment implicitly privileges the observer.
too bad there was a slower paced more casual version - yellow alert or defcon 5
What are you on about? GraphQL is absolutely essential in enterprise systems.
> Oooh noo the man took a picture of himself with his dog outside

Seems like some of you have the same prejudices as the physiotherapist. Grow up.
I did not dislike your comment.

The reason I considered easy was because I have very little knowledge in this area, in fact this is the first time I ever ran a machine learning model on my computer.

I could not do it with the unmodified pytorch model (my GPU is not powerful enough to run even the 7B model), but I was surprised on how easy it was running with llama.cpp. I literally just followed the steps in the github page.

But I was biased in saying it was easy, since I do have other knowledge (such as C development on Linux) which helped me.
that's what I really like about KDE, there is a lot of configurability.
I've been there, brother. Hang in there.
Pretty much anybody who plays an instrument figures out why after a while.

This was perfectly demonstrated 13 years ago:
https://www.youtube.com/watch?v=5pidokakU4I

I know a lot of comments here are trying to show how hip they are and that garbage on top-10 Spotify is totally good for you - commendable attitude. Truly. But happens to be misguided if you develop your ears. Which you should. Has nothing to do with being an old fogey, pop music really has gotten worse for various reasons.

Start here, maybe it will hook you:
https://www.youtube.com/watch?v=Gt2zubHcER4

Once you understand you can't unhear it or pretend otherwise.
There's so much amazing music being made it's hard to keep up.
Your welcome again?
That's like bacteria in a Petri dish saying:

"I struggle to believe that The Pipetters are objectively real because I have a basic grasp of the size of the laboratory room, how much of it is just empty, how hard it is to travel between the bits that aren't, how inhospitable almost all of it is to bacterial life, and because everywhere we look it seems primordial and uninhabited. I don't think that is prejudice."

Don't forget, we're mind-bogglingly primitive and ignorant. We don't even know the laws of the universe yet! (ie unify GR and quantum mechanics)

Of course we haven't figured out UAP-type technology, whether what we're seeing is interstellar travel or something more exotic.
>"Pierre Paslier [...] wanted to create packaging that would come from nature and disappear into nature, quickly. With a friend from graduate school, Rodrigo García González, he created a company called NotPla, short for “not plastic.”

From an East London warehouse, they designed an edible sachet of water, made of seaweed and other plant extracts: To drink the water you simply pop the sachet in your mouth. They designed another one that can hold ketchup and a third for cosmetics."

There would seem to be a large market for non-plastic easily biodegradable waterproof containers (for whatever product) -- made from seaweed...

Related: https://www.notpla.com/
When You Cannot Trust the Experts
And yet doesn't it defy probability that such raw physical determinism would lead to us having this discussion? And if not, is it not amazing that simple subatomic physical applied to a gaseous soup leads to us discussing these questions?
Yep. You can get decades of the best, on demand.
If I build a desktop app using one of the above-mentioned technologies, there is almost nothing "distributed" about it. HTML, CSS, Javascript. Which is where 99% of my UI building happens. The only thing "distributed" what comes to my mind and what I think you mean is what would be an API call in the browser, to fetch some data that the frontend needs. The equivalent in Electron/Tauri/etc. is usually some bridging API that you can call instead.

I never missed any GUI builder. Browser dev tools are phenomenal IMO, you can drag&drop elements across your layout, change any part of your styles and instantly see the effects, measure rendering performance, memory consumption, debug your Javascript or simulate different screen sizes.

About React, nobody forces you to use it. There is a myriad of frontend frameworks, at all levels of complexity. If you feel your app is so simple that you don't need any framework, you can do without. Frameworks (and again, there is a huge world outside React!) came up because they make managing state in complex UIs easier.
#1 "I'm old and I don't understand it nowadays and it's too loud"
I think it's even worse than that. AI will claim it is socialisation, and people will believe it. Chatbots and their enthusiasts will claim they're just as meaningful and valid as in-person human socialisation, and will actually make every much, much worse.

But as a former secondary school teacher, I can already tell you a lot of these kids don't know how to socialise. They have no concept of empathy or of there being real people out there. All their socialisation is pretty much done only through their phones, and it's not good for them at all. I was like that myself - very shut-in type guy from about 13-16 even though I did have friends and school to help, and I still find myself struggling with a lot of social cues and stuff that I should've been developing then.
Very little of what the IA does is strictly kosher under current law more or less anywhere in the world. They've mostly gotten away with it because, for example, they've mirrored websites that the owners put out in public and generally respect even retroactive requests to take them down. And, as you say, lending out 1 digital for 1 physical is reasonable enough that it's easy enough to believe publishers would overlook.

(And, yes, they're a library/archive but that basically means nada in the digital world.)
At least I'll get some rest when I'm dead!
Great post, though I was low-key hoping for a top 10 or maybe top 100 ranking of most starred juiced-up repos.
You never were. There’s always been regional music scenes and styles and pose networks of people connecting them through zines, mix tapes, etc. Easiee today though.
(Unlike Haskell,) Scala does not force monadic composition on you at all. You can use Scala as a pure OO language, or for old-skool ML-like FP where you don't use monadic context abstraction. I've done both successfully in production. Indeed I strongly advise against a monadic programming style for programmers with a mainstream programming background (imperative and OO).

In my (considerable) experience of teaching programming, imperative programmers find jumping straight from imperative programmers to a monadic style extremely difficult, the more experienced, the more difficult.
If you sleep for 20 extra minutes every day, that's a full extra year sleeping over a 72 year span. (If you exclude 1/3 of the time as sleep, that's a year and a half of extra awake time.)

If you gain 1.5 years of extra time awake but lose 0.5 years of life, did you win or lose time?
> I am saddened to say that the prosecution appears to have a strong case here.

This is a civil case so plaintiff not prosecution. This comment made me double check that there wasn't an associated criminal case I was unaware of.
Not everything needs to be cross platform.
Why would banks take more risk with their deposits? The bank executives, shareholders, and bondholders wouldn't be personally affected by the loss of deposits anyway so I'm not sure they would care either way. If deposits aren't guaranteed, they lose their investment, and if they are, they still lose their investment.

> Unless the insurance is paid for by the banks themselves

It is though. The FDIC insurance fund is funded by premiums paid by banks.
It's a real shame, I thought they were trending in a different direction by actually releasing large projects as open source under permissive licenses.
As a tangent, I got a new bed couple of weeks ago. My old one had been around for ages and was well past it's expiration date.

It cost a small fortune but Jesus Herbert Christ on a tandem bicycle has it made a difference on how I feel during the day. I fall a sleep faster, wake up more well rested.

First few mornings I was just sort of confused by the feeling of waking up profoundly physically relaxed. Felt very weird and unusual. I don't think I've been that relaxed for years.
great start on such a crucial topic

The United Nations has a forest group, here is one of their docs https://unece.org/sites/default/files/2022-05/unece-fao-sp-5...
> The narrative you are presenting is also based on common sense though.

Yes that's my point. Common sense was never with the peanut bans. Common sense was with peanut eating the entire time.
Peanuts compared to gold
> In theory, as the density of uranium is 19.1g/cm3, which is approximately 70% denser than lead, tungsten gold plated bar and tungsten alloy gold bar could be used as material of making fake gold products.

Why does this article begin talking about Uranium and lead and then immediately non sequitur into tungsten? There must be something I'm missing?
I’d like to learn more about the project history, who started it (early contributions), and the context under which the early work was initiated. Wikipedia has exactly two sentences on the history. Is there a better version of the Nix story available?
So, one of the main points about going nuclear is that the externalities are more limited and contained than existing solutions.

We already release radioactive waste from coal based power plants (plus all the other bi-products from the ashes).
Blamed 4 kids for sleep problems. Turned out I picked up sleep apnea somewhere when raising the littles. CPAP changed my life.
Smartphones and emails already destroyed our lives me and Brandy my golden retriever's lives!
I've had best experiences with pyright, i.e. fewer false negatives, reasonable speeds and good error messages.
The comment to which you were replying mentioned both the excessive local disk usage and the excessive network transfer, and so your comment appeared to apply to both portions. This is why I started my comment by explicitly restricting it to the case of local disk usage.
Thanks Domen,

devenv.sh is quite nice, and have already started using it.
As someone who's been involved in music and also went to Berklee like the author, he's basically right about all the points except that he's talking about a sliver of the industry. Rather it's "Why does major label music suck so hard". He asks "ho - is the next David Bowie, James Brown, Prince, Van Halen, Joni Mitchell, Notorious B.I.G., U2, etc." - there isn't because the music industry has split into many many fragments each tiny label specializing in a niche.

A David Bowie wouldn't go through a major label because he would get treated a lot better with a smaller label, however wouldn't reach the same heights. Also there's honestly TOO MUCH good music out there, so major labels can't pick who they're going to focus ungodly amount of energy into promoting.

It's true major label music sucks right now, but honestly we're living in a golden age of music overall, it's just way harder to seek out and find.
Me too, when code ownership allows it, and someone pays for my time doing so.
Note that in the example shown in the website, Gnome Calculator is not phoning home, but imf.org; probably a benign thing; it just showed how much control one can have over one's computing.
Maybe the solution is simply to end retirement. As in end the social security for old people.
Fucking hell crypto is such a colossal waste of resources
> When was the last time you saw a community stay the same... ever.

I see it a lot . I see and am part of groups of friends (6-12 people) who have existed for decades. They're very stable. People do join and leave over time, but the "churn" rate is very close to zero.

I think this sort of thing is much more unlikely with communities that aren't small, though. The monkeysphere is a thing.
I've been going through another episode of sleeplessness lately. Just like it had before, it has serious detrimental effects on my overall wellbeing. I'm less trusting of others, more inclined to shirk social situations, more sensitive to antisocial behaviors in others. I struggle with telling cause from effect, because these things literally stress me out even more, exacerbating the sleep problem. I just _feel_ the sleep deprivation eating away at my general health.

I'm getting the best possible treatment (standard of care) which is cognitive behavioral therapy, but man, is it a slow process to recovery.
Lol, always a bright side!
> information that couldn't exist in a book or a blog post

I think that exists somewhere. Maybe not something that is specific to situation, but there is enough information out there that can lead you easily to the solution.

That’s why I prefer research instead of this AI assisted workflow. Instead of giving me the specific knowledge I need, it lets me know what I didn’t know and give me much more information to reason about.
Next.js can also do Gatsby-like static generation, but also update those generated pages if the content changes in the backend. They call it incremental static regeneration (ISR).
This is the new pattern for almost any successful free software provided by a corporation. Make it nice enough to start building a user base, and then slowly make it more terrible to find a way to extract value from it.
SVB collapse: Shopify wires money to merchants with payroll problems
Yep, this one is the headline item for me. Look at the code and, if it has further dependencies of its own, look at the code for those too.

The main question I'm asking myself while looking at the code is: if I had to fork this thing and maintain it myself, how would I feel about it? Because sometimes that happens.
Fair enough. According to his thesis, the metaphysics/philosophy aspect of this stuff is in a right hemisphere bucket. While there may be reason to meditate on that if you’re a researcher wanting to gain better intuition, if you want to use physics as a tool, the aspects useful to the left hemisphere are all you need/the thesis is irrelevant.
You're going to need to give exemples here. Upgrading has been super simple.

The one time you actually may have had to work on things was with PHP 7, but that's because they finally removed things that had been deprecated for years, some for over a decade, and all of them were security risks or massive code smell anyway.

The one thing with PHP 8 was the removal of dynamic propery, and again that's a massive code smell that was holding the language back. Any code still using it when PHP 8 released was either written over a decade ago, or something that has way more issues than that with upgrading.
“The obvious conclusion” only seems “obvious” for a small group of people who always seem to think their violence is justified by their odd morals.
Do you still experience these UX issues and lack of documentation?
> > Parents with Munchausen’s manipulating their prepubescent children into socially transitioning is a good explanation for the rise in prepubscent children socially transitioning.

> Without a causal mechanism to explain the increase in both the incidence of the disorder and that particular manifestation, its a pretty crappy explanation

Eh, what? It's right there in what you replied to:
The manipulation is the causal mechanism.
Better not drop this on your foot...
I don't have any complaints for Raspbian specifically (in fact I really like it on the Pis), it just strikes me as odd for newcomers to go for the niche distros.
When your machine metrics are recorded it is much like a fingerprint. Who is tracking you can sell to you better, which by definition means you get a worse deal. Also you are better surveyed for how you can be used. You think KDE doesn't have people who do this?

IT-sort of people on the internet: "Security is very important. We dont want to get hacked"

Also IT-sort of poeple on the internet: "Why are you paranoid of a tech company is collecting your data? You really think they are gonna hack you?"

Also others in the field: We need Intrusion Prevention Software, IDS, pfSence firewall, etc... So we can be safe from hackers while our machines host extra automated services we dont need, among reasons.
> How do you evaluate 3rd party dependencies?

I actually blogged my answer to that exact question recently (shameless plug):

https://philbooth.me/blog/how-to-evaluate-dependencies
We are talking about one very specific issue, the point of this thread is a joke about new and delete. And your response after evidence services against your position is, “what about all these other things?” Definition of whataboutism.
Ultrasound testing is probably a weakness.

Edit: Sound passes through tungsten and gold at significantly different rates. Also, a "mixed media" type material would have extra "echos" that a homogenous thing would not.
Absolutely. I would also not use new/delete in that situation. It would depend on the audience whether they were still taught on a course, sometimes there is, and sometimes there isn't an educational purpose.
VSCode is distributed! It supports connecting to a remote VSCode "server", so that you can edit files over SSH for example.

Of course, 99% of the time the server and client are ran together, so you don't notice it is distributed. But that doesn't mean it isn't.
I don't think any of his points apply to K-Pop, which AFAICT is an intensely studio driven sound.

Which might explain why some people love K-Pop and some hate it.
Genetic data links SARS-CoV-2 to raccoon dogs in China market, scientists say
swyx is on hn and legit great writer. He's influenced my thinking in many areas.

I've never seen his github account before but I expect that people following him there are doing so because of the content he's putting out. His blog has been on the HN Frontpage many times and has a book about developer career building.

My github account isn't as pimped out as his, but marketing yourself isn't toxic, it's smart.
Nothing you’ve described sounds like a valid reason to move “a couple of spreadsheets” to a database system which might require: budget planning, database administrator, system design, server, colocation, query optimization, report system, monitoring, user interface, backup/recovery plan, authentication system, change management logs, user training, business process analysis, etc.
Having more than two people in the house who can act as parents is a game changer. Definitely one place where modern society has slipped up, though there's some change in that with families like mine.
Most big projects offer a large transition period. And their "older" version works just fine on latest PHP versions anyway, so you have the time to do your upgrade. And the tooling to make such upgrade is very stable and well working, rector does 99% of the job.
People Used to Say LLM Cannot Understand Meaning of a Sentence
Linux/Unix Nbench
WHO blasts China for not disclosing potential data on Covid-19’s origin
The only thing more annoying than that is when you pick a fight with them about their reasons and they insist on believing that you must disagree with their conclusions.
Smartphones and emails, all the apps has already destroyed our lives me and Brandy my golden retriever's lives! AT&T among others that's a huge problem asI don't care what others do but why am I still on this smartphone?