skysight-inc/HackerNews huggingface dataset:
It may be possible to detect Covid-19 with Nanopore's Minion?

Rapid and Accurate Detection of SARS Coronavirus 2 by Nanopore Amplicon Sequencing. Xiao-Xiao Li and al.

https://pubmed.ncbi.nlm.nih.gov/35464969/

https://en.wikipedia.org/wiki/Nanopore_sequencing
My take is that Deno borrows a lot from web standards and functionality provided accross browsers.

In the case of dependency management, they use a pattern which would also work for client code shipped to a web browser (in that case the client would assemble the code - like if you had a reference to load mathjax or google analytics or whatever, or you could alternatively vendor and ship them yourself).

To me Deno is basically modern web standards + very nice tooling for use as a scripting or serverside language (typescript interpretter, format, compile, vendor, test, lockfiles/import maps, ability to explicitly include/exclude capabilties from runtime, etc).
Can AI Improve the Justice System?
So now Salesforce will reduce costs by firing a couple of developers. Or a couple of percent of staff.
> My understanding is that Windows or macos do not offer this kind of stability over time.

This definitely torpedoed your argument (ask any enterprise Windows user). First, "Linux" in this sense means what a normal user sees as Linux, which is a GNU/Linux desktop with a DE such as Gnome or KDE. You're correct that the Linux kernel ABI is stable (at least in userland), it would be simply wrong to say that "Linux" (as would normal users encounter) is ABI-stable.
ChatGPT works best with analytic prompts that respond with translations and not synthesis.

Meaning, if all the facts exist in the prompt then the likelihood of synthesizing fiction is diminished.

There are a number of ways to use the principle of analytic augmentation to add most or if not all of the facts required for a truthful response, ranging from simple “prompt engineering” to evaluating code to document embedding in latent space.

For example, if you use prompt engineering to k-shot a task to turn math word problems into executable JavaScript, meaning LLMs are only translators and the computations are done by a software interpreter, then the results are much more likely to be truthful.

Sampling from a number of variations on a prompt can lead to a more accurate outcome if say 1:10 times the translation attempt has a different answer.
Engineering arbitrary modifications is incredibly difficult, due to a myriad of factors, like working against evolutionary optimizations, lack of knowledge of the target organism, reaction pathways that don't go quite like we've sketched them, unspecific enzymes, etc. The success stories you read about are a very small fraction of all attempts. And like another user said, some things are easier than others.
Well, their products are really expensive (like, outrageously expensive for a hobbyist). From them, I only bought geneticin and something else relatively unsophisticated; if I can source the compounds I need literally from anywhere else, I'd be better doing that.
I'd imagine they'll stir up the pharmaceuticals market as much as meth cooks did. If someone makes an actual advancement with these kits, watch him get bought out tout de suite.
United States tells citizens: Leave Russia immediately
Sure thing! Give ‘em a post here and I’ll answer as best I can.
It's very easy to give bacteria certain antibiotic resistances, the mechanism is pretty much identical to the one used to make them green fluorescent in these kits. You transform the bacteria with a plasmid, they take this up and produce proteins from the genes on it. Those plasmids in the kit almost certainly have some antibiotic resistance on them anyway, that's the way you filter out the succesfully transformed bacteria.

The good news is that the resistances you can give this way are typically present in nature already. Bacteria are already exchanging these kinds of plasmids. And the bacteria you get in these kits or generally use in the lab are also harmless to humans.

I don't think you could effectively design a bioweapon with the stuff you have in such a kit. That would require a lot more knowledge, effort and material. I think at best you'd be able to create a resistant bacterium similar to those that already occur sometimes in the wild.
This post doesn't meet the criteria for a "Show HN" posting. Please review the "Show HN" rules: https://news.ycombinator.com/showhn.html

"Tell HN" may have been more appropriate for something like this.
I can see Blindsight taking the place of 1984 as the “this is so true” book of the decade. Articulate, eloquent, but unthinking and unfeeling machines with no interior experience are going to be puppetting our culture for years to come.
It depends on the solution, Loki for instance has support for it: https://grafana.com/blog/2019/08/13/lokis-path-to-ga-live-ta...

With that said unless you tune your query it's very easy to get overwhelmed once you scale a bit and start getting larger log volumes.
Why? There could be better ways to implement, like just applying this as systems meet their natural end of life rather than rewrites. If we're fine with ideological legislation, then why not for other things?
> What is the conclusion we should reach then -> engineers are unnecessarily noble and should not allow themselves to be exploited?

That's not the conclusion, unless you think that Class Warfare plays a role anywhere. I don't.
I don't agree with that assessment. Passing luxury goods down from generation to generation is not common. The issue is much more with the immediate value of the product: the average luxury bag is used maybe a few times, likewise the churn in the world of high-end sports car is very high. The problem is not that Apple Watch's aren't timeless, it's that they are so saturated that you can't turn them into a luxury good because there's no signal associated with them. If I see a person wearing an Apple Watch I have no idea how much it's worth, it says nothing to me other than they have an Apple Watch. If I see someone driving a Ferrari, I know immediately that it's high value.

That's why you'll see people buy old barely functional luxury goods (like mid 2000s Lamborghinis which barely work any more) because most people don't realise they're dirt cheap now, and so the cost to signal ratio is very high. Look at Maseratis: awful garbage cars in most cases, but because they look nice, lots of people trying to signal wealth and success will buy them for cheap, despite an almost guarantee they'll be worthless.
Yeah, a "regular university" signs up students right off the streets of Siria.
Establishing product-market-fit is part of marketing.

I think you're confusing marketing and advertising.
Would I like a world where people are always entitled to know what code runs on their devices? Absolutely.

Would I like a world where people are always entitled to know what code runs on devices they don't own?
Absolutely not.
If it gets bad enough where info on the web is completely unreliable we might see people reverting back to TV and media empires in search of "trust" and "vetted info". The internet would be treated as poisoned. Still an utterly grim picture. But this betrayal would have to be mighty.

This is not going to happen, isn't it? Even if riddled with chatbots is still persuasive enough to generate engagement. Some could choose dark corners, but for the majority would be business as usual.

Speaking of business as usual, how the fuck the ad business could survive this? The only way out that I can see is it if IDs are forced on us somehow, but that's a shitshow in itself.
i'm going to have to agree here.

today's MSM pundit-oriented journalism has been a carry-over from legacy yellow journalism pioneered by Hearst and Joseph Pulitzer.

yet we've somehow managed through institutions. it will centralize and decentralize as the dollars ebb and flow from NYT to Twitter to Substack and in the short-term we will converge into a fragmented information digest.

in the long-term i predict we will leverage those same technologies + cryptography for sense-making in an adversarial information environment.

i think the future will look more like balaji's ledger of record + yuval harari's defensive AI.
People always forget—chemistry exists everywhere! And if a lab can buy it, you (probably) can too.

Anyway, hopefully this goes somewhere and we start seeing more DIY scientists running amok. It's high time for move fast and break things, biology edition.
iGEM, at least for students?

https://igem.org/Competition
In a message broker architecture, it is typically the clients connecting to the broker. Thus, as you correctly point out, they need to know where to connect. But that is the same value for every single client. Using the failover transport of ActiveMQ, we have defined amq1, amq2 and amq3 - so it'll cycle through these until one of them answers.

Once you're in, you only refer to the queue names. Which in Mats effectively are direct references to the endpoint name, typically in a Java-style class.method way, e.g. "OrderService.placeOrder".
I was thinking current laser weapon tech would be ideal for this.
It's pretty uncontroversial that the printing press was instrumental in the reformation and Martin Luther's ability to spread the word. It wasn't like Gutenburg invented the printing press and immediately everything became different: it was a slow-motion revolution which took many years (as well as further improvements to printing technology).
An argument could be made that impacts of each of the things she coveres has overblown and used to fear monger people into reading articles about them that Vox sell ads over, the reveue from which her salary is paid. The commenter seems to be drawing our attention to that and suggesting AI may be a new bogey man of sorts.
I learned the term in grad school. Wikipedia seems fairly accurate.

"Many criticisms of the Dunning–Kruger effect have the metacognitive account as their main focus but agree with the empirical findings themselves."

https://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect#...

Would it even matter? It's regularly used to describe a common phenomenon. You understood what the Parent Comment was describing, as did I. For that reason alone, it's effective communication.
The risks right now are roughly these:

- AI poisons political discourse

- AI produces massive wealth inequality

- AI makes many white collar workers redundant

These look totally manageable to me. And on the flipside we'll get AI assisted science breakthroughs, AI assisted learning, and much more. I fully expect to see wild AI advances in the coming years, especially once AIs will be able to learn effectively from their own generated outputs and will be able to use external tools effectively (like Mathematica).

I get that it's scary to because society is going to change, but on the other hand, the paperclip scenario that some SV prophets have warned about seems increasingly unlikely.
https://www.mongodb.com/licensing/server-side-public-license...

>The copyleft condition of Section 13 of the SSPL applies only when you are offering the functionality of MongoDB, or modified versions of MongoDB, to third parties as a service. There is no copyleft condition for other SaaS applications that use MongoDB as a database.

no question about it. You use it as a DB, you are clear. it only triggers when you want to serve as a SAAS
That is a rather well constructed rant... agreeable in the substance behind the rhetorical questions. Especially in this anti-intellectual social-climate that is all-pervasive through and through all institutions of the west, and the infantile ideologies of that took hold of the western elites. (I single out west here purely for the contrast of where we come from intellectually/philosophically to where we are currently which to me is easy study case).

However, while we would agree, I wonder which "natural" processes are really to be understood to stand behind this decay. Of cause, it is not new, we can read already in Sumerian tablets, Greek and Roman then witness accounts of their empire's disintegration and how in fact people did clearly perceived the rotting (just as we do now).

In other words, identifying the symptoms (as implied in the question you posed), is one thing. To understand processes inherent in the system of systems itself is yet another level. And then, thought I do not think possible, one can postulate how to slow down, or even reverse such trend. (I would say natural trend in the phase of natural systems of societies).
Yes but keep in mind that in Germany an s1 time share lab ( including equipment ) of 25m2 can be rented from 10€ per square meter.

That is less than you pay rent.

They really want people to do bio stuff.

https://www.bio-security.de/s1-s2-labore-bueros-mieten/
> Imagine you can no longer trust any information, because the internet is being swamped by generated half-truths.

So like the world was about 20 years ago?
Is not AI, the same as smart phones, cars, industry, social media, and so one was for the humanity in some point of time? It was conceived to serve, then it slaves us, but then we get used to it and move towards the freedom again, moving it to where it initially belonged to? Regarding the AI, we are going to end up with a scenario like an endless loop of AI generated content that gets posted to the web as original human generated content, with LLMs getting re-trained on this content and spitting out more content that also gets re-posted, resulting in a cesspool of BS masquerading as organic knowledge. We will end-up going back to books to get useful information, and going back to real people to interact with people.
Why bankruptcy? Are people on HN in debt?

Ofc they would have to change their lifestyle if they had a 20x decrease in salary though.
I wonder what the industry attrition rate is. How many move to another tech company, and how many move on to a new career? This boom is old enough that a large portion of people who got in at the start out of college (or by skipping college) should be in or approaching their 30s where people start reevaluating their priorities.
It is experiences like this that have lead me to stop using Windows 15 years ago. I do all my development work on a desktop system I built running Debian. Use an old ChromeBook for when I need portability, e.g. in meetings, when traveling, etc.
There are restrictions on the sale of dangerous chemicals, and in general the vendors that sell chemicals simply don't sell to private persons at all. I'm not sure where the exact legal boundaries are, and whether the typical stuff you need for genetic experiments falls under some restriction. In general the chemicals you need for that aren't that dangerous, so they might not be restricted by law, but you still will have trouble getting a reputable vendor to sell to you as a private person.
UBI in theory is a great idea, but the likely implementation terrifies me.

Inevitably you'll always get someone / some group claiming they deserve more than others because of x, y and z, and certain groups with more political power / influence than others will naturally want to direct where the money flows based on their own personal prejudices and objectives.

Posting hate speech on Twitter? You're "free" to do it, just don't expect to get the same UBI as everyone else. Oh, you're a racial minority we'll give you 20% extra UBI to compensate for the discrimination you suffer.

This is just human nature.
AI is not any different than a bunch of people working together towards something. AI is the people. People are the AI. Just imagine a corporate entity - with little nodes running around making neurologic synapses and making decisions all based on their statistical understanding of the past etc.
This offering seems largely educational, this stuff being what people learn in bioengineering degrees anyway. And this stuff isn't really plug-and-play :) Most beginner attempts will simply fail (e.g. dead target organism, no change to desired traits, etc.). Any serious bioengineer (incl. ill-intentioned ones) would have more advanced equipment and knowledge anyway.
Seems like e/client and e/server are for when you'd like to force sections of code to run on one side or the other. Otherwise the compiler decides what lives where?
And we're only seeing it from the IT sector point of view. IR35 also wrecked the HGV driver market and is one of the reasons for the shortage of drivers.
How have you gone “socisliam? Why do you want fascism?” about UBI?[1]

Who has ever suggested that UBI means your income forcibly reduced to UBI and nothing else allowed?

[1] from the arguing style “you want free at the point of use healthcare? Why do you want gulags and mass graves?”
Yeah, he's using the words interchangeably in the interview. Talking a lot about "marketing" with Facebook ads.
Since we are talking about an imaginary technology here, why not imagine the robots don’t experience consciousness? Problem solved.
hey chatgpt we need a spin on how ai is actually human
why not?

if i use an MIT code as a "user" when i am an "intermediary" and repackage the same as a proprietary one, my "users" will be end users. they will get only proprietary code, rendering incapable of enjoying 4 freedoms.

This is the same thing. if your or your downstream end users' freedom gets restricted, that is a problem
An argument could be made that they're not though
Ask HN: Getting into AdTech, where can I learn the domain and technology
Hello HN. I realize AdTech is not something HN finds interesting. I am getting fresh into this domain and technology.

What are some good books, blogs, videos on the technology behind advertising platforms? Where can I learn it better? Thanks in advance.
Yes. There will be autonomous weapon platforms everywhere regardless of our desires, both from nation-states and non-state actors. To defend from them, you might want to understand how they work, and how they are built.
https://archive.ph/CwUEW
I'm just imagining Cocaine Bear 2 being made about this.
> That's why monopoly, or monothlic architecture eventually failed. They can't scale.

Could you provide some examples? One counterexample: Linux, the world's biggest monolithic kernel, seems to be going pretty strong.
Yes, they do ship outside the USA (I ordered their kits from Switzerland, they arrived in a few weeks).
No. only if you resell the DB as a service, then only this clause of SSPL gets triggered. otherwise it is Agpl...

if you use SSPL product as a DB, it is same as AGPL
If you're in Europe, then order your PCBs from Aisler (no affliation). They are a sponsor of KiCad, and you can add a small donation on each order. Direct upload of KiCad files, good turnaround time, and decent prices.
I mean, the standard library is inspired in golang's[1], so I would assume that other parts of their design are also inspired by go.

[1]: https://deno.land/std@0.177.0#contributing
This have the same output formats plus it's own Jojo-format to open in an atm internal Mac-app and in the editor-feature-branch.
A long time ago , I hooked up all my docker images to send logs to AWS Cloudwatch. Now, regardless of which cloud or VPS I am using, all my logs are at AWS Cloudwatch. So that's one less headache for me.
> not going to look like Terminator

we're approaching Brazil.
Ah, the invisible hand, yes.
It’s been so helpful so far.
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that's a new point of view?
> I hope one day someone will figure out how to merge reactive notebooks (Observable-style, not Jupyter-style) and spreadsheet

I'm working on that exactly - I have several conceptual designs for presentation and interaction, that's where my wit concept comes from as an abstraction to represent cells in the reactive graph, which can be seen either as an array or as a single cell with a label and a prototypic value. Once you liberate the concept from the 2D grid, dependencies between variables create lots of interesting navigation and presentation problems and expanded possibilities.

Unfortunately I don't have much time for side projects and my programming skills are a bit rusty, so I haven't advanced much in terms of actual implementation. Moreover, my 'universal' requirement of having it available as a system-wide background service would take a lot of work :-(
I always used EAGLE for my PCB work in the past but just recently I started a new project, after many years not touching any PCB design, for which I need to make a PCB and gave KiCad a go.

Most of the things work fine but the managing of part libraries I found extremely confusing and not really intuitive: e.g. different library file formats for schematics and footprints or the standard libraries being located and hidden behind some PATH variables..

Regardless, I think it is a great piece of software and I am looking forward to make more use of it in the future!
Sometimes by accident it will, but most of the time it keeps making things up with no regard to factual and logical correctness. It has no notion of truth.
I suspect a good many of us have mortgages, yes
spreading from the inside
Yes! I'm working hard on it, I've been distracted with other work for some of our clients but hopefully have something to show soon.
The video was created to highlight an extreme, where it should be very obvious that it was faked. However, an actual attack will be subtle.
But more impressive is that it understand a lot of other languages then just English. Really impressed with hard-to-understand Norwegian dialects.
edit: assuming this wasnt /s

you got me, putin secretly sends me bitcoin, and photos of him riding horses shirtless, as I so desperately crave that.

What a marvellous argumentative tool you have, anything you disagree with that can in some way be classified as "russia might think this way", and you have a magical out where you percieve yourself to have won the argument. And with moral superiority too!

I have heard that putin recommends you breathe oxygen regularly, I would strongly recommend you cease listening to russian propaganda, and do the right thing here
Another one? It's getting old. She needs a new shtick.
Do they have a choice? The claims they've made (fully backed by cash equivalents, separated reserves safe even in bankruptcy, always available for 1:1 redemption) [1] will be considered fraud if they don't redeem all $16Bn.

1: https://www.binance.com/en/blog/ecosystem/understanding-busd...
booby traps are illegal, but not in time of war (well, maybe)
Well, the point is that you can make almost every library a network service if your want to.

Anytime a vendor sees a GPL3 library, all they have to do is make a network service out of it and the GPL3 license is powerless.

So AGPL3 as the default for strong copyleft software seems reasonable.
No, LVMH has mastered the subtle art of tight rope walking that is the modern luxury industry. The trick is to be a mass market company while keeping the margins of a luxury company and preserving your image as a luxury company.

If you look at the Vuitton catalogue, you will indeed see products which would definitely be seen as luxury goods: the best Italian leathers, costly assembly techniques, products painstakingly handcrafted in places known for their mastery of the craft. All of these a pretty decor to sell perfumes with global appeal (read uninteresting) and overpriced handbags.
East German doping? No. This all looks way more like the lobotomy craze of the XXth century.
They go out and get jobs at more financially responsible companies, or start their own. There is plenty of work.
Ok. Our service is pretty fast. Also the M-Macs is really fast imo
the critiques is not about that, but to the fact that

- it wasn't a catastrophe

- it didn't bring down the Church, on the contrary, it strengthened its authority