skysight-inc/HackerNews huggingface dataset:
I'm not a virologist, and this is taxing to my memory, so it will be a bit more basic than you might prefer, and won't be as accurate.

> Could it be that requesting that the cells produce additional proteins of a particular kind "overloads" them or simply "asks too much" in a fashion similar to a virus?

It could be. I believe that most of the cells that express from the mRNA vaccine do indeed die (from the immune response against them). I'm not positive about this though. In general if a cell is preferentially producing protein from a particular mRNA it doesn't have to resources left to do what is expected of it (including cellular maintenance).

> then what is causing cells to explode due to virus replication?

https://bio.libretexts.org/Bookshelves/Introductory_and_Gene...
"During release, the newly-created viruses are released from the host cell, either by causing the cell to break apart, waiting for the cell to die, or by budding off through the cell membrane."

According to the video below it can be caused by crowding. I think it can also be caused by virus proteins, or an apoptotic response - programmed cell death done to hinder the viruses ability to replicate more infectious particles. Often enough the cell does not burst, but simply buds off new virus. This is still very detrimental because the cell isn't doing what it is supposed to do, instead having been hijacked to create new viruses.

> If so, have we encountered a virus that "opens up" a cell without damaging it and eventually becomes parasitic to the host?

What I'm going to say won't directly answer your question, but it will answer the question you would have had if you knew a bit more. You want to look up lytic versus lysogenic viral replication. A basic overview: https://www.khanacademy.org/science/high-school-biology/hs-h...

A more general overview of viruses linking directly to the part talking about retroviruses (the most common route of viral lysogens in animals): https://bio.libretexts.org/Courses/Mansfield_University_of_P...
Wow, that's a lot larger than I would have expected.
See also libigl for geometric processing:

https://libigl.github.io/
I haven't looked at many web scrapers. Do most use CSS selectors? What about xpath? I always found xpath to be much more powerful.
Is this something go developers also have to be careful with when using goroutines?
It's what they do that matters, and there is no country in the world today which is responsible for nearly the amount of brutality, oppression, and exploitation as the United States. And child poverty is potentially the most alarming example. Despite being the richest nation, the domestic United States has proportionally more child poverty and child hunger than any other major nation in the world.
Looks like corn is the audience score and strawberry is the critic score, sourced from rotten tomatoes.
Happy 9th birthday, Qutebrowser!
And yet a minority of obese people had no problem with COVID.

To be consistent I hope you also don't accept health advice from seriously underweight people either.
It leads to an interesting paradox wherein human-written content becomes simultaneously more valuable and worthless. Increasing amounts of human effort becomes worthless because an AI can produce the same result. But at the same time, the AI needs the human-generated content as an input (at least for now), and so it will place a priority value on it. Also, human-generated content will become valuable due to basic economic scarcity: when the world is flooded with AI-generated content, buyers will pay a premium for human-generated content.

This implies we will need reliable methods for identifying the provenance of online content, which may spell the end for viable anonymity in many places, or at least accelerate us toward some kind of proof-of-personhood (a hard problem to solve in a privacy-preserving way, and indeed one that leads to the very same questions of what makes us human and gives us an identity in the first place). Short of such a reliable method, the best option for identifying human-written content will be filtering to content that was posted prior to ~2023. In a world of AI-generated content, your shitposts from 2015 may become a valuable commodity.
Something else conspicuously missing from these services is a checkbox to make it never show me something again. Why do I have to scroll through an endless line of "nope", "nope", "nope", "definitely not", "no" every night, then look at all the same stuff tomorrow? Does someone get paid when I have to sacrifice a brain cell for each of these minor decisions?
I finally installed Gentoo last year for the first time. I am pleased to say that Gentoo will be my distro of choice for the foreseeable future.

One of the best aspects of Gentoo is how easy it is to understand its working parts (portage, openrc), and to customize/modify a working system. This is in contrast to, e.g., Debian/Ubuntu, which I used for years, and which bring in a lot more complexity to do the same things.

I'll also admit that while the theory of Nix always seemed to hold promise, I've never actually went through with installing it as a distro on a base system. To me, the premise of Nix---essentially, that it can provide an abstraction of pristine system state transitions---doesn't seem to mesh with the reality of physical computer systems; which is to say, state and mutability are not bugs, but features of your computer.

On source-based/"ports"-style package management: I think the way to approach portage is to put yourself in the role of a sysadmin in charge of maintaining a set of Gentoo installations. So, if you want binary packages, you will need to ensure it is set up right yourself (possibly using portage's own binpkg tools, or some other way). There's a certain DIY/rugged-individualism to this approach; but the design and implementation of Gentoo enable and encourage opening the engine hood.
Looks like currently the agents interact in the simulated world only. Would be interesting when combined with robots from Boston Dynamics or similar and see how it learns to adapt and operate under real world environment and constraints.
I do believe they have some kind of "monetization" going on regarding what they recommend you. Even YouTube apparently.

They suggest the same thing over and over under "different" categories. I they go try to force "popular" content on you.

One of the reasons I made this joke/rant project

https://victorribeiro.com/recommendation/
I wasn't responding to you.

But sure, as a fat person who, as far as I know hasn't ever had COVID, I think my advice is pretty good.
Only ones I can think of are that Clang has better(ish) error messages, and clangd language server is cool.

Used to be Clang was faster than gcc (both compiling and the apps generated), but according to Wikipedia they now trade blows.

Some people are very much against the GPL. I don’t know why they put corporate interests over users interests. I assume it’s a cousin to “temporarily embarrassed millionaire” thought processes.
“Money laundering” became a crime in 1986. The bank secrecy act originally just introduced the $10000 threshold ($80000 now) and record keeping requirements. It was later amended in the 90s to add suspicious activity reporting. Nearly all of the major mafia cases predate this. There are many reasons for this decline (https://www.journals.uchicago.edu/doi/10.1086/706895) but mostly it has to do with RICO, wiretap evidence becoming admissible, the witness protection program, changing demographics, and more federal prosecutions where the people involved were smarter, less corruptible and where the sentences were greater. I am incredibly skeptical that it had anything to do with the decline of organized crime in this country.
Clicking one of the results, it seems to mean Average Tomatometer and Average audience score … both from Rotten Tomatoes.
That's a strange conclusion. Gaps in the crust under the surface of the sea will if they open up deep enough cause sea water to come in contact with magma which will rapidly solidify and if it is less deep it will simply fill up the gap, the interior of the earth is a ball of molten iron covered with a layer of molten rock and given the density difference there is absolutely no way that water would displace any of that.
Based on its discovery during dredging operations, I didn't expect to see an onshore explosion. Did they move it before attempting to defuse?
Right, the reference Tcl implementation is still in C. This project takes the C code and produces Go, along with a supporting libc emulation in Go. It's still the original C code, not a clone as Jim or Picol.
I also wonder how many hours and points I wasted into jump to jump across the roof tops, haha. I absolutely loved the server based physics, even though I had the crappiest dial up connection at the time. I was 14 when I started playing that game. So many amazing memories, Atlan stones, spell system, cheesing death items, being afraid of losing everything because there's no bank, haha.

Lately, I've been getting more and more into esoteric topics and I keep thinking about this games lore... There is so much occult knowledge/history baked into the entire thing and I honestly still use the game as a reference point for some many things.

I'm curious, do you know how the games lore was developed and were there ancient texts that were inspirations for the events?

Thank you!
The comment above should clarify a few things.

Unfortunately, I don't have a reference, as I was told this by an advisor from PWC a few years ago. I guess you could contact any good tax consultant, tell him the details, and let him look into it. I have no idea about how 401K works in the US.
Honest question: why are you vaccinating while you also identify as low risk?
Here's a video summary of the research:
https://youtu.be/U93bUQ1roiw
I remember being so frustrated by the ZZT programming language because it lacked so many fundamental features. IIRC, you couldn't even sum variables.

But it didn't stop me from spending hours and hours creating ZZT games. At times it was fun to try to figure out how to do things. I once wrote a music sequencer.
https://www.norfolk.police.uk/news/latest-news/communities-t...

https://twitter.com/NorfolkPolice/status/1624133384069959682
I don't think anything is faster than django-admin. If you invest time in understanding how it works then you can accomplish a lot in very little time. Results are of course not perfect, but good enough for many quick-and-dirty projects.
It doesn't need to be explicitly funded, different licencing costs can be enough. It could be cheaper for Netflix to show their own productions than pay for a stream of licensed content.

You can disable autoplay previews for all devices on Netflix' website in your profile.
Plus if they‘re constantly on there they may have watched all of the content they like on these platforms.
> the U.K. Centre for the Observation & Modelling of Earthquakes, Volcanoes & Tectonics (COMET)

TUKCFTOAMOEVAT worked hard to get a cooler name.
And yellow numbers seem to be Certified Fresh.
> Large language models have taken the public attention by storm – no pun intended.

As far as I can tell, no pun made, either!
No. But sometimes goroutines have the opposite problem, where they don’t terminate and get cleaned up.

https://betterprogramming.pub/common-goroutine-leaks-that-yo...
Looks like chrome needs an overhaul. Witness me.

But it an all seriousness this is pretty cool. I just wish I had a sue for it.
No. Goroutines don’t generate a reference to hold onto, either. They just run until they or the program terminate.
Also paradox of choice / overchoice phenomena, where the more options you have, the less you feel satisfied with any of them.
https://twitter.com/pusholder/status/1623815189257719810/ will get you there
The real problem is that each platform just doesn't have that much content. Everyone wants their own platform, and now the content is so fragmented that if you noped out of titles for very long you'd realize they have very little else.
Say the line, Bart.
But envy is one of the most pervasive problems in today’s world, especially as social media normalizes the successes of others, making you feel like you’re “underperforming” the average when in reality you’re being shown a highlight reel of outliers. You’re always comparing yourself to someone ahead of you, and the goalpost will keep moving because the algorithm ensures that it moves on your behalf. And whenever a hierarchy like this exists, the fingers of envy creep within.

People say this like it's a truism, but the notion that social media only shows successful people or is like a highlight reel of life, is possibly false. Unless your social circle is limited to tech founders or celebrities, most people live pretty mundane lives. https://greyenlightenment.com/2022/04/27/still-skeptical-abo...

I don't see what is wrong with envy per say. What is wrong with wanting more. Envy is a major motivating or driving force of getting better at life.
yawn For those of us that actually use ChatGPT on a daily basis it’s an incredible productivity booster.

We know that it’s a language model and you can get it to say naughty things. So what?
DI is not a pattern to provide the defaults but a pattern that allows you to separate dependency initialisation from your callable's responsibilities, which often is a complex graph of inner dependencies that you would need to provide/initialise in some way, it also can handle whether you want to have single instance of such dependency for your single call, request scope, thread scope or process scope. Also injecting some defaults from configuration object or some properties/setting file is very nice feature.

Also stop being so religious and defensive when somebody mentions things that are not standard in your language of choice as nobody forces you to use this.

I was sucessfully building very testable and maintanable codebases (~50 kloc) in Python while also using very small in-house built DI framework and it was subjectively (by me and my collegues) much better than what we had before while we followed standard Python patterns and ways Python frameworks teach you to follow.
Ask HN: What are you building that is taking multiple years to make usable?
Hi HN,

What are you building right now that's taking a while to make? Are you authoring it yourself? Why is it taking so long to write?

Talk about it or share a link with us.
yeah, metadata performance sucks arse, but it serves a purpose.
Mind double check url? Getting 404
Alternatively, tack `/export?format=pdf` to the end of a google doc. It generates and displays the PDF version on the fly. i.e. https://docs.google.com/document/d/______/export?format=pdf
Looks like it was maybe dredged up and that's a) how they found it and b) why it's on the side there.
> The lion and its prey are in cooperation only...

Lions cooperate with other lions, humans cooperate with dogs, symbiotic organisms are all over the planet.

Humans are apex cooperators. Our civilization, from planes to schools, from the banana that you eat this morning to the microchips of your computers, all comes from a very complex cooperation between humans. Remove the trust to cooperate and we go back to live in caverns. Nobody cooperates better than humans, ants or bees cooperation is just on basic functions, we are way better than that.
But seriously, for open source projects actually looking for contributors (vis-a-vis companies with a developer product they just make open source), there is no better resource.

To understand a framework, you need a mental model of it. Good documentation is helpful, but it seldom walks through why specific design choices were necessary.
That's extremely insidious. I suppose I never encountered this issue because I almost always call asyncio.gather(*), which makes having a collection of tasks natural.
This looks pretty good, thank you for sharing. I have a feature request: ordering by number of seasons.
How to find good product ideas on Reddit
That video looks uncanny. I suppose it's due to the lighting and the low resolution/focus, but if you told me that the entire video was a GPU rendering I would probably believe it.
Is there an (easy?) test for checking goroutine leaks?
Sarbecoronaviruses are a subset of betacoronaviruses. And I seriously doubt we have a comprehensive sequence database of all sarbecoronaviruses. If furin cleavage sites are present in about 21% of alpha- and betacoronaviruses I would expect they would also be present in a minority of most lineages within these clades. "Furin cleavage sites are also found in certain bat-origin MERS-like merbecovirises"

> For such a specific motif to arise naturally seems to require a scenario like multiple infection of a host species by several different wild-type coronaviruses.

Two would be enough. And we know that happens already (ala XBB, deltacron, etcetera).

> > "So far, a viable natural origin for the SARS-CoV-2 S1–S2 site through recombination or mutation of a bat-origin virus has proved to be elusive. Of note, the S1–S2 cleavage site of SARS-CoV-2 S does not comprise the pattern found in prototypical furin cleavage sites (it is RRxR and not RxK/RR),8 making its origin enigmatic. One feature of the S1–S2 junction for the SARS-CoV-2 spike from the original outbreak is the presence of a leading proline residue, which might have promoted furin cleavage."

This is interesting, indeed. I wonder why an engineered site wouldn't use the prototypical cleavage motif, instead using one that might need (if I'm reading the quote correctly) a leading proline residue in order to promote cleavage?
IMO Netflix and Amazon Prime's problem is they don't surface their good content enough. They mix it with their shitty content. They should make it stand out. HBO are good at this. When they make something good, that they know is good, they will rub your face in it with large high quality images.

I don't have time to shift out the good from the bad with Netflix.
Article says they built a sand bunker around the bomb to provide protection in case this happened. Sounds like the bunker did its job!
I actually went back to pirating movies/shows and host them on Plex.

I sure have a much smaller collection than any streaming service, but it's actually all content I like, and I actually watch stuff instead of just browsing for 20min.
In comparison, Godot's python-like GDScript prefers tabs:

https://docs.godotengine.org/en/stable/tutorials/scripting/g...

I have come to appreciate tabs here, but you have to have already established tabs as the prevailing convention for this to work.
> so a separate, "standard" choice in typechecking was made called mypy

This distorts reality a bit. Mypy is one of the flowers; Jukka developed the annotation syntax. It got popular enough to become the de facto standard. I would say the strategy worked.
I remember reading that they have an algorithm that picks the "best" (colorful, cinematic, attention grabbing...) picture to show in the UI from the content itself. That is why sometimes the poster used represents a very minor character instead of the main lead.
I think DeepMind is really good at solving “spherical cow” problems. They can model a very simplified model of a small aspect of the real world and solve it brilliantly.

However, there is a big question of how much the results are actually transferable to the real world.
For Amazon the issue for me has always been that aside from the things I shop for myself I get asked to buy things for other people or presents for family members

Amazon doesn't know who I bought something for so making sense of why I have bought 4 padlocks (my father in law), a set of sauce pans (wife), a light novel (myself) and rechargeable batteries (myself)
C++ has nodiscard which is super useful for scenarios like this where ownership can be tricky.
Maybe they push content that is cheaper to license optimizing for some sort of license-cost-per-viewer-hour metric
its also possible they wont show you content you really want because its licensing is expensive, and instead they nudge you to content with higher % rev split
It certainly bothers the person(s) who left 'Mask off!' graffiti all over my neighborhood.
> In general, when working in C I avoid the standard library, libc, as much as possible. If possible I won’t even link it.

Completely agree: freestanding C is a superior language. I'm so happy to discover I'm not alone in thinking like this. The author is very thorough in his criticism of libc, I learned a lot from the post.

> The platform code is small in comparison: mostly unportable code, perhaps raw system calls, graphics functions, or even assembly.

For me this is what made programming fun again! I don't even bother with multiplatform implementations anymore, I go straight for Linux system calls. Turns out to be a much better interface compared to libc.

> On some platforms it will still link libc anyway because it’s got useful platform-specific features, or because it’s mandatory.

If anyone would like to know why such a thing would be mandatory, I began writing about this subject literally just a few days ago.

https://www.matheusmoreira.com/linux/system-calls

Still very much a work in progress but it does provide context for his claim.
and thank goodness for that
This issue doesn't exist with Trio's structured concurrency model. In other words, the problem is already solved.
One thing I really like about RDS is the query visualizer. It shows which queries ran when and for how long and what they spent their time waiting for, CPU or disk or locks or whatever. It’s really good. Are there any free tools that show a similar view?

edit: i think it’s called performance insights in RDS
The description of the attention mechanism of GPT architectures and a couple of examples can be very brief. Then you have to supply your imagination and realize that the model simply found a whole bunch of very effective such attention measures by itself, which are all computed for every query, and they could be anything from the straight forward examples, or some more clever abstract types of attention. I think we'll need some more descriptions of what the more important attention measures it comes up with really are, to understand better.
"Attention" is the would be pun, I think.
I got a tip from someone here and shifted to tracking what I want to watch with a seperate system trakt.tv.

This lets it recommend across different services and removes incentives to promote their own content (I'm assuming someone at Amazon and Netflix is trying to goose their own stats by boosting the content they self create, or that they pay the least for)

A link (and a free recommendation for an interesting show):

https://trakt.tv/shows/giri-haji

It lets you do nerdier searches like by director, writer, actor and similar to openlibrary.org it has some weird old stuff too.
What a joke.

He says "There is no thinking moral agent inside.", but then, after a few examples of asking ChatGPT to write dialogue for the devil, concludes "some serious darkness still lies within".

First, being capable of responding with "serious darkness" doesn't mean that it is dark. Second, suggesting that darkness lies within assumes there is a moral agent inside.
But I have the same experience on youtube.
Is it thinkable that after "hundreds of hours binging series and movies" you have simply exhausted the options?

Me, I haven't found a second The Wire yet, no matter how often a recommender claimed I have.