skysight-inc/HackerNews huggingface dataset:
In the wiki article, the section on synthesis describes how it’s made from lidocaine as starting point.
Another name for it is actually “lidocaine benzylbenzoate”.

If you take a look again at the diagrams, you’ll notice that it’s almost exactly the same, except one of the N now has a benzene ring attached to it.
They were clear on it taking 15 minutes:

In the end I got the charge reversed, cold comfort, I was out a quarter hour...
Probably a huge short squeeze.
Though the tech layoffs have hit the development and infrastructure teams (I mean all the tech layoffs, not just twitter), it is my understanding that the majority of people laid-off are in sales, management, and administration.

Users won't see the impact of this as much. Perhaps some slower pace of releases (twitter was already painfully slow from what I understand), slower hiring, etc.
I'm just saying that it seems as though (especially given the messaging that Wall Street has given to the public as it pertains to their position on the debt ceiling crisis) that Wall Street is probably happy to say "let them eat cake" for those who can't participate in the new economy.
Buran was radically different - no internal rockets, just jets. Unmanned optionally.

The most interesting thing is that the launcher (Energina) was actually also used to launch a space battlestation.

No - I am not kidding.

https://en.wikipedia.org/wiki/Polyus_(spacecraft)
Yea, I think the point-in-time, annualized R&D expense on 2023/03 will be the midpoint of the reported figure for 2022 and 20221. (~$30bn, where EOY 2022 was $35bn and EOY 2021 was $24.6bn).

The layoff, we can imagine, impacted maybe 15% of R&D at most.

It might still be too high in 2023, depending on what their revenue figures do in Q1/Q2. Would be interesting if they needed to do another layoff -- doesn't seem outside the realm of possibility.
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I am very rarely concerned about debugging my usage of Java streams, and step debugging works fine in the context surrounding them.
Below is an OSS alternative, originating from same engineering as stable diffusion. There is other awesome work in rom1504's Github I recommend exploring as well.

https://rom1504.github.io/clip-retrieval/ (usually performant)

https://github.com/rom1504/clip-retrieval
> Everyone’s data goes to Google when they use Google. But everyone’s data goes to a bunch of random companies when they use ChatGPT.

No, their data goes to random companies when they use random companies. And these services also exist for google.
In the last 3 months the entire market has come back up. I have safe agricultural stocks that have risen nearly as much in this time. FB bouncing back and having a low PE doesn't make it a good investment. People are looking longterm at their prospects and where they're dumping their cash and they don't like it.
> Essentially, a way for me to present my customers with a plethora of integrations out of the box without having to build them all myself.

This is an itch I'm waiting for someone to scratch
> Yes but it is much harder to scrape and replicate a site’s essence if the instructions are laced in a story and the essence includes the story

It's also objectively a harder to follow recipe (i.e. a worse one).

But that isn't even what recipe sites too. Open up google search type in a dish name and hit "I'm feeling lucky". I just did it for "mushroom Alfredo", you won't believe what happened next.

- The first thing below the subtitle is a "Jump to recipe" button.

- What gets jumped is 6 screen widths of rambling interspersed with highly produced photos, 3/4 of which are clearly advertising shots for the company that sponsored this particular recipe.

The fact that the very first thing is a "jump to recipe" button indicates to me that even the author knows that you (the reader) want the recipe and not whatever they're about to ramble about. So why include it then? It's certainly not about copyright, the author is actively helping you not read it. The conclusion that makes the most sense to me is that the text is there to a) sell as advertising space for food-related sponsors and b) for SEO (go read through the sentences, each one seems crafted to hit on a different reason why someone might search for this recipe).

> Merely copying the recipes in a popular cookbook would not make for a bestseller.

It's true, but slap a celebrity's face on the cover, ghost write (or even chatgpt) a few hundred words of intro before each book and BAM you have a stereotipical book in the cooking section.
Ross wasn't convicted of soliciting or conspiracy for murder though. He was convicted on a more generic conspiracy charge which only needed the prosecutor to prove overt act(s) and the speech for the conspiracy -- possible overt acts could be things like facilitating drugs or transferring money or hurting people. The jury never indicated the overt acts they included were anything related to murder, and the judge should have never presumed the jury found him guilty of anything related to murder. I don't think it's clear he agreed to pay to kill someone, at least not from a criminal perspective.

Regarding your statement. I think both are wrong. If agreeing to pay someone for murder is real violence, then so is offering murder. Both the cop and the one paying should be jailed.
How are the computers so bad?? I don't know why, but it's personally embarrassing to me as a developer.
I'm not familiar enough with that part of world history to comment. Speak plainly.
"Best new 2023 top 10 monetized link page match you like it please adword affiliate link such many money give me".

Take my $20.00
It's pretty universal and some of the features not implemented by files in traditional Unix (e.g. network connections, remote devices) work well in Plan 9. Though I think "everything is a file" is a misnomer in the context of Plan 9 - rather, everything is a name in a system of namespaces.

Interesting related paper which also gives some cases for which names don't work too well (one example is shared memory): http://doc.cat-v.org/plan_9/4th_edition/papers/names
Selling SaaS services B2B vs B2C is a large topic, and which one's more lucrative for OpenAI is hard to pin down. How many individuals do you know pay for Google Workspaces or Office365, vs how many companies pay for it? Or how about GitHub CoPilot? Or Trello? Obviously those are different products which makes direct comparison hard, but people don't pay for things, that's why there's stealing, and why so many things are ad-supported or ad-"enhanced".

We are in the midst of tech giants fighting, with the consumer as the loser. (Quick, try and buy a book in the Kindle app on iOS!) I don't see a future where it's possible to run (whatever evolves into being) speech ChatGPT on an Apple device with Apple support.
Wow is right. This feels kind of ... speculative.
Can you give an example of something that was resolved for you by this?

I can send a letter if it will do something but I can't convince 10% of the population to send a letter.

I've sent messages to government offices and never got anything but a canned response and no action.
I think it's worth separating Twitter the product and its success from Twitter the corporation with financial obligations. The product side will be determined by so many factors outside of any one person's control it's fun to speculate on but that's about it. On the financial side, based on what's publicly known so far, it's not a great situation in terms of servicing the debt of Twitter. Elon can always pay for it out of pocket, of course, but that's not the normal approach anyone would take and as a result it's much more interesting to watch what happens there.
There's very little new syntax added by TS
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Its interesting that the temporary fix for this is to generate some file, edit it, and import it back in... What else goes into this file, and why?
See my comment here: https://news.ycombinator.com/item?id=34618514
The anti-war people, not so much... or did something change since <insert major US military operation that started in your youth>?
How about those world class mathematicians working at subway?
It's red until compared to real red, then it looks red-orangy. It's an older discontinued XP-E, the first generation of them. Oops, actually, it's 625nm[1] I wanted the Photo Red XP-E, but they were hard to source at the time.

[1] https://www.ledsupply.com/leds/xp-e-emitters bottom of first table.
Complex systems decay over long periods of time.
OK, but a good sign that you're not using a cryptographic RNG is that you're somehow "seeding" it.
Good one, did not know that law but it's on point.
Fair point. I struggle to find metrics myself.
i have a 5€/mo data simcard (500mb) i got many many years go. I have no use for it. To cancel it they put me through hell. My hour is valued at €200, i have no choice but to let them milk me for eternity. Or maybe someone comes up with a service for cancelling stuff/complain etc. I'de give them 50€ to cancel this crap.
I’m just really happy how resilient the economy is at this point.
https://artifact.news/
I have a kind of powerful dirt bike. People put “throttle cams” on them for this same reason. Usually you want small adjustments within the lower range of power. When you want the majority of power you usually want close to all of it.

Throttle cams are basically an off-center circle. At lower throttle you’re pulling a smaller circle and the throttle moves less. Then when the throttle is opened up you’re pulling a bigger circle.
Again, you are wrong.

Julia Child had nothing to do with writing the Joy of Cooking.

You have no fucking clue what you are talking about. Sit down little man.
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Heh, yes. This runs into something like Poe’s law because you can find people who sound exactly like that but are serious. I especially remember someone’s reaction when their hand-tuned assembly started under-performing compared to GCC once we recompiled for (IIRC) Pentium 4 chips.
Isn't the C preprocessor a type of metaprogramming?
It's not just the Puritan work ethic. The dearth of support and extreme scarcity of housing play a huge role.

If you won't center your entire life around work, there's a long line of people who will, and your employer would happily hire one of them and throw you into the proverbial wood chipper of being unemploymed in the US.
How do they make all this money when everyone I know has stopped using it?

Other countries?
> objectively this means you still get ads just less releavnt ones, no?

business might choose to not show ads at all vs showing irrlevent ads. Surely there is a downside and risk to showing ads, a risk that cannot be taken willy nilly.
The BBB is a private organization that a corp has to agree to be a member of and pay dues to. They're as much of a failure as Yelp.
In German too. Pigeon==Taube==Dove
The guns in 1888 didn't pull those triggers by themselves.

Shifting blame to regular people only serves to further insulate corporations from the harms and costs they have externalized, and we should be vigilant to make sure we are not enabling them.
If it's truly "any" kind of Numpy array typing won't help much there I agree.

But often
it can be helpful to know the shape of the input and the shape of the output. Eg are we working with a 2D,3D or ND array.

Before 3.11 it was not simple (possible?) To type this. But https://peps.python.org/pep-0646/ makes it possible. If somewhat clunky on the definition side.
Screenshot: https://cloudflare-ipfs.com/ipfs/QmcjrYXR934QZqBuMHioRdcZEmo...

On small displays this is otherwise obstructed by a cookie popup that offers only an “accept all” button. What’s even the point of the popup then?
The crash seemed speculative to me. This feels like a return to normal honestly.
Serving Files in Python: How FastAPI Failed Us
I have never seen anyone in my third world home country just carrying or even owning an SBC. Even the poorest people just buy a phone because it's wildly more useful and does not require a peripheral. Otherwise, they buy an older computer that can be had for cheaper than most SBCs.

Actually, I'd argue that the market segment is squarely a first world one, mainly because it's far from the most convenient computing platform and alternatives are far more useful when you can only afford to own a single computer. Being unable to make calls or use messaging apps (access to whatsapp is almost a requirement in tons of countries), and coming with no built-in battery makes them a complete non-starter as a potential main device.
I pay more than that for electricity and fuel. It's not strictly renting and there are no ad pop-ups, but it's a recurring expenditure and prices can (and did) increase. Once I use it, it's gone - I can't resell or rent it either.

It still makes sense for me to pay because I get more value compared to if I didn't.
Of course, we are rebuilding nuclear reactors every 10 years from ground up. And of course that "just changing few MWh in batteries" is the cheapest part of whole battery storage.
The point is, if you want to make your web app the most performant as possible, cross-platform solution has limitation.
> That's unbelievable for how little there is to show of it

They multiplied the size of the market by an order of magnitude and they dominate the entire VR industry now?
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I was responding to:

> Many countries could have the capability to produce decent chips.

China might be able to, lets see. "Many countries" definitely not.
More cynically: Roughly 2.4 tons of fuel, equating to 16.8 tons of CO2 emissions.
> For example, I wanted to do something in 3D the other day and reached for react-three-fiber, there simply isn't something comparable in the non-React world.

Respectfully, that is because you dont _need_ anything other than ThreeJS in the other frameworks.

I do find it interesting that it says it performs faster due to reacts scheduler.
Relaxing neck is... checks notes gendered somehow?

What makes a head tilt feminine?

Playful/serious - sure, whatever chose what tone you want... but feminine - why do you say that?

Isn't the head tilt usually indicative of paying attention, listening, and being curious - how are any of those things feminine (specifically)?

Seems incredibly dumb to me... more so, the people that pay attention to those things - and classify them into gendered boxes - I have lower opinions of what they would espouse as advice. Exactly the same as people obsessed with machismo - it is silly, and petty.

More to the point: it seems kind of sexist that men would be taken less seriously if they tilt their head...

And super weird implications about how femininity is perceived in general as antithetical to leadership: that's just plain sexism right?
I bought a small amount of META when the narrative of its downfall hit its peak. It’s the first individual stock I’ve bought in 12 years. I’m now going to be up about 60%.
I did a fairly detailed breakdown regarding the Python library Parsy: https://lukeplant.me.uk/blog/posts/python-type-hints-parsy-c...

This is not to make the general claim "Typing is a hindrance in parsing applications", or anything close. It's saying "the current static type system(s) available in Python would have made this Python library much worse".
Taleb may have said this, but be aware all he effectively did was take Bertrand Russell's Chicken parable [0] of 1912 and replace the chicken with a turkey without adding any philosophical value.

[0] http://www.ditext.com/russell/rus6.html
People are ASTOUNDED when I ask them to crop me out, or to ask my permission before posting with me in it. I'm always polite, but people act like I asked them to lick the bottom of my foot.

Most people are happy to have photos with themselves in it. Like it or not, you're the strange one in this situation.
Drawing stuff on a map with a GPS track is a rather beaten path in the world of Strava and similar [0]. Not being bound to the road network graph just makes it easier. I don't want to think about the fuel burned for this stunt, but if I were in some position that is required to sign off that flight path I'd sure congratulate whoever came up with this. Wouldn't even be all surprised if tomorrow some Airbus ferry flight would respond in the same medium with a respectful salute to the old lady.

([0] but relative to anything that would be considered a tradition in aviation, the entire concept of GPS is rather newfangled, despite it's surprising age, I'm not disagreeing)
A fee for parking in a private lot during a period when they weren't supposed to be charging fees (free holiday parking sponsored by the local shops).

Verizon bill for unreturned equipment (didn't ask for it, told them I was leaving it on my doorstep and not taking delivery, it disappeared, heard back a year later with a fee).

TMobile bill.

An incorrect water bill.

A car dealership lying to me.

Issues with one of those "order for ipad" airport places mentioned in the article (same issue: never received my food).

Medical bill from an urgent care for some trivial thing that they told me they wouldn't charge me for.

Some interest on a student loan that accrued because their billing system messed up.

A bunch of other stuff I'm not remembering.

I always just send a written letter and if I don't get a check in 30 days go to the AG. Works every time. Fixing their petty crime is not my problem.
> Respectfully, that is because you dont _need_ anything other than ThreeJS in the other frameworks.

Not really, ThreeJS is imperative, react-three-fiber is declarative. I use the latter for the same reason I use React over jQuery, I don't have to mess around with appending nodes, I can lay out my view declaratively and have the framework fill in the rest.
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That link was... an interesting read. I'd say it merits a NSFW tag but it's kind of obvious from the title.

> Pinyan had previously lost the ability to experience certain sensations after a motorcycle accident, and he had begun to seek out increasingly extreme sexual acts

Almost feel bad for the guy if it weren't for the animal cruelty.
ShareX 15.0.0
Online recipes were the catalyst for me switching from Chrome to Brave. It doesn't remove the filler copy, but at least there's not an ad every 2 sentences.
In the case of card fraud, you don’t have a contract with the actual account owner. So taking that money results in THE COMPANY fraudulently charging a card. Again.

In the case of an actual dispute (non-shipment, etc) you do have an actual contract. However, this smells like extortion(?). You didn’t deliver on your end of the contract (deliver goods) but are penalizing the other side for your failure to deliver. It won’t go over well when you get the class-action suit, and all the little ones in-between.
There's a weird self fulfilling prophecy aspect to it. People mock it, people notice it, but also have decided "this is what these pictures look like," and they conform when the occasion arises.

When we went public and the first wave of new c levels rolled in and cheeseball chat avatars started to show up in our ecosystem we mocked them. None of us even used real photos at the time except HR. They spread though. People still make fun, people who have them make fun, but it's a thing you do when you're Business. Humans are funny creatures.
Except when you can't. It's routinely over capacity for free users.