skysight-inc/HackerNews huggingface dataset:
Many bacteria which can grow in anaerobic conditions end up homing to solid tumors (where there is no more oxygen) and then either directly kill cancer cells for food, or stimulate a local immune response which can promote clearance of the tumor.

W. Bush and F. Fehleisen found back in the 1800's that patients accidentally infected with with Streptococcus pyogenes often had regressions in solid tumors.

William Coley's refined this and came with Coley's toxins, which when they worked, worked really well but comes with its own risks:
https://en.wikipedia.org/wiki/Coley%27s_toxins
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888599/
https://connect.springerpub.com/content/book/978-1-6170-5273...

I think many mycobacterium species also have this effect. Also, bacterial extracts such as the BCG vaccine are used for bladder cancer.

More modern strategies try to take advantage of the bacteria's ability to home to the inside of solid tumors in order to deliver a toxic payload to directly kill tumor cells, or molecules which locally wake up the immune system.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264239/
https://www.prnewswire.com/news-releases/synlogic-presents-d...
Maybe the clinical results weren't so great though since they seem to have removed it from the website https://www.synlogictx.com/pipeline/.

If you count viruses as microbes, then there are people working on viruses that kill tumors as well (oncolytic viruses).
Unfortunately it is so common ACLU had to send a warning to a long list of hospitals CBP works with [0] to do this kind of thing as part of a lawsuit [1]. They still haven't stopped and the hospitals continue the searches, in fact I was sent to one of the hospitals listed.

A woman (who they never even got a warrant for and nothing found) at the hospital I was at was forcefully penetrated in a pretty disgusting way and I'm unaware of any significant remedy for her despite a lawsuit [2]. The lawyer who took her case told me they'd given up on such cases when I spoke with them. I complained to the relevant medical state board and they basically said everything is kosher.

While in the hospital with officers, I had the opportunity to ask them about their history in regard to this behavior. They bragged to me of various nefarious activity, such as taking someone in because they had a trans female-to-male "appendage" so they accused it of being a drug smuggling apparatus apparently to fuck with them. It was clear to me in these discussions it is routine and common behavior, and they voiced to me it was profitable for them as they commonly were paid a very high overtime wage to sit in the hospital which is easy work compared to their normal job at the port of entry and allows them to buy expensive trucks.

2 (relevant details start bottom page 6) is a pretty brutal read.

[0] https://www.aclutx.org/sites/default/files/aclu_hospital_adv...

[1] https://www.aclu-nm.org/en/press-releases/cbp-settles-lawsui...

[2] https://storage.courtlistener.com/recap/gov.uscourts.azd.985...
Rust does have a fix for this:

error: this arithmetic operation will overflow
--> src/main.rs:2:18
|
2 | let a: u64 = u64::MAX + 1;
| ^^^^^^^^^^^^ attempt to compute `u64::MAX + 1_u64`, which would overflow
|
= note: `#[deny(arithmetic_overflow)]` on by default

Rust also allows for overflowing arithmetic (preserving the default to fail):

https://doc.rust-lang.org/std/?search=overflowing

It's generally less ergonomic, e.g.

let (zero, _did_overflow) = u64::MAX.overflowing_add(1);
I don't know the exact workings, but usually the authentication popup should popup with at least 1 other factor to challenge(e.g. touchid or password) if it hasn't asked recently. That way it uses 1) something you are (touchID) and something you have (Validation from a known good device) as the 2 factors.
Estimates done from the design are pretty common, and BIM programs (Building Information Management) like Revit integrate all of the construction details into the design model, so they are able to automate some of those calculations. But BIM programs are not great design tools (not sure if that's an inherent conflict or if there simply aren't any good ones) so they are not popular for smaller jobs like single-family homes where you can use drawings produced directly from a tool that provides a better user experience for design.

Unfortunately, the drawings don't give you any assurance that the construction details are done correctly. Corner-cutting aside, a contractor may depart from the design with good intentions and accidentally create a thermal bridge that sucks heat in or out of your house.
The idea is great, but what about security? When you get the user's cookie and session information (basically you're taking a snapshot of the browser and reproducing it at your end), you can do anything with it. What if someone uses it to take a screenshot of their bank account? (probably not possible due to two-factor authentication)
[Disclaimer, I am on the Wing team]
Very good read! There are many tools in the space, each suitable for diff needs. Wing, as an infra and code solution, targets developers of resource heavy apps who'd like to work at a higher level of abstraction, yet remain in full control to embrace the diversity of the cloud.
More details soon :)
The simple example in the article is demonstrated: you have a fail safe condition, not a fail open condition. Since you only need to flip one bit, unlocking the bootloader is trivial. If you need to flip multiple bits, in a specific pattern, this makes the challenge exponentially more difficult.

For something like the reset glitch hack on the Xbox 360, for example, they were glitching a single opcode to do the compare with the checksum. Multiple ways to defend/harden against that attack (which, likely, were implemented on the Xbox One).
> You can ask, "how will this work in practice?" and few people will be able to claim they've actually thought as far as that.

This seemed to be the central problem of Brexit as well ...
Leaf is a "city car" which is an euphemism for very short range and slow charging using a dying standard.

MG4 is the cheapest EV (£30K) sold outside of China that could reasonably compete with a Corolla. There isn't much else in the cheap bracket. e-Niro and ID.3 start at £35K.
The vast majority of problem drinking is done by like 10% of americans. I don't think a warning label is going to stop them when they already consume a HUGE amount of alcohol every week
(speculation)
OpenAI monetisation objective, business model and cash flow situation etc. would be different to Microsoft‘s.

OpenAI has indicated interest in generating revenue because compute costs are “eye watering“
Why would it be?

The purpose of laws like the 4A is to prevent the police from harassing innocent people by going on fishing expeditions. The purpose of the poisoned tree doctrine is to prevent the police from committing crimes as part of their work.

But if a plains-clothes police officer sees you load a kilo of cocaine into your car every Tuesday, on the same street corner, there's nothing illegal or immoral about him telling a uniformed cop to show up next Tuesday, to observe you doing just that. I see no reason why the uniformed cop should be compelled to reveal his source.

Now, if the plains-clothes officer was doing warrant-less break and entry in order to observe you doing the crime, that would be an ethical problem.

This does create a bit of a connundrum - where you often can't tell if parallel construction was used to cover for legal, or for illegal behaviour. But I see no reason for why the first case I presented should be forbidden. If pressed on the stand as to why the officer chose that street corner to be on Tuesday, they can avoid prejury by declining to answer, or just say that they were tipped off. I find it doubtful that a judge would compel the officer to answer, or to elaborate - he's not the one that's on trial, after all.
Are the big commercial options such as Unreal and Unity significantly better when one attempts to do this sort of "off the beaten path" type stuff?
Just like any other hobby: Start following instagram artists you like. From there, start looking at their workflows and tutorials on YouTube. Find some subreddits for art/music/whatever that you like.
Avoiding Moravec’s Paradox Solves AGI in Five Years (2018)
I found the other package: https://www.npmjs.com/package/friendly-querystring (noting mostly for my own sake)
Ask HN: What low hanging fruit security issues should static site owners check?
Inspired by: https://news.ycombinator.com/item?id=34408831

"Of course...take the time to make sure there aren't any real, low hanging fruit security issues in your site, and take time to set up monitoring so you catch unknown issues quickly. You know...things that you should do anyway."
Anyone can do federal taxes via free file fillable forms on the IRS website, and it is super easy.

https://www.irs.gov/filing/free-file-do-your-federal-taxes-f...

Any half decent state also offers free online tax returns. If all you are is an employee with stocks/bonds in a brokerage that gives you the necessary forms, it is super easy.
If you don't care about max current performance (frankly you probably don't), then picking up a used M1 pro or M1 max is a much better value proposition. It doesn't seem like the other upgrades are very substantial, maybe Wifi 6E but displays, design, otherwise it's likely to feel essentially the same.
I truly loath product hunt in its current state.

It's just a game of who can get the most friends/bots to vote.

Further, it is only relevant to those present in the echo chamber.
I don't have a published study.

But, when some fool calls me on phone and tries to sell me something, I can ask them to remove my phone number from their list. And it actually happens, they won't call again. Pre GDPR they were like "yeah sure dude" and just kept calling every month or so.
This is an interesting article, because I "feel" like my leisure time is less than my parents and grandparents. This is in part because they retired at earlier ages than my current age, with pensions for my grandfather, and better financial situations overall. I feel like I have less leisure time than say people in the 1950s, up to 2000 maybe. But where is the data? This article says for the US, hours worked are around 40/week from 1960 through to 1988 (+/- 1 hour), table 5 https://eh.net/encyclopedia/hours-of-work-in-u-s-history/

It's hard to compare in part because there are very different lifestyles. As a member of the fortunate "programmer class" I have high pay, health insurance, easy job portability. This leads to pretty reasonable vacation schedules, good lifespan. Overwork expectations and stress are the downsides, but these are within my control somewhat and I can just get another job.

This research paper says leisure time increased noticeably from 1965 to 2003 - an increase of 6-8 hours per week for men and 4-8 for women. https://www.nber.org/papers/w12082. This is a surprise to me and goes against my intuition. Maybe we always feel like we are getting a bad deal.

Don't forget the sizable number of lower hourly wage Americans where some people work many hours at low pay and barely support themselves. Americans seem to work significantly more than our European peers https://20somethingfinance.com/american-hours-worked-product....
Does ChatGPT have true intelligence?
Are these the same lawmakers that allowed this?

https://www.theguardian.com/uk-news/2023/jan/16/metropolitan...

Which exec will be jailed?
When I finally got a smart phone 5 years after the iPhone came out, one of the first things I tried to do was train myself by not getting service on it for over 3 months. The idea was to make sure I had other kinds of content on it that weren't update-hits; mostly eBooks and saved long-form articles, plus some map apps for navigation. So data engagement was limited to WiFi islands and focused on practical business.

This was definitely only partially effective, probably because I already had bad habits from my laptop. OTOH, to this day I do have at least a rudimentary deeper reading/writing flow for my phone I can focus on without too much conscious effort, so it wasn't useless.

My conclusion is that most of us probably would benefit from either intentional choices or self-imposed restrictions... but most of us could also probably benefit more from a combination of both.
(I'm an EM at Plus) Yeah, we think about the permissions/data escape a lot. I'm glad to see others are commenting with scrutiny too. We've put a lot of effort into our security model, since we know that we're handling very sensitive data.

To give a bit of a peek in: All of the session data we store is encrypted with a key unique to each organization, managed through AWS KMS. We've also built a fully event driven architecture, so every action that occurs in any of our services is logged and auditable. Access to our production data is extremely limited, with our default role grants not allowing access to sensitive data at all. (We have an in-app issue reporting tool to let a customer grant us access to debug data)

Overall, our hope is that we can work with IT departments to help them understand how Plus works, and allay their concerns if a company sees value in using Plus. Making sure our security model is top notch is one of the top priorities for our engineering team.
Using that definition, “efficiency of an investment” is quite apt for the characteristics of a home which do not involve monetary return. In other words, I want as much X for every dollar I put in. X can be comfort, curb appeal, U-value, etc.
There's a few things to unpack here. One is the perception of the iPhone. Eg here's a quote from PC Magazine I saved when it came out: "Poor business e2mail and PIM connectivity. Bad audio quality on phone calls. Tons of GSM buzz on nearby speakers. Virtual keyboard hard to type on. No phone functionality with iPod speaker docks. It’s the best portable media player ever. It’s possibly the most fun we’ve ever had with a handheld device. It browses the Web like a champ. But poor phone call performance and missing messaging options make us unwilling to recommend it as a phone." There are similar other criticisms. It was not part of the category of smartphones at the time as seen by the people using them.

The early criticisms about Tesla's build quality and a lot of the arguments about a battery not being good enough seem to follow a similar argument. Is the original Model S as good as a top of the line gas car at the time? By most metrics used at the time, no. The criticisms in the peer comment by
lbsnake7 are similar - those are legacy metrics of a car. However it did find a customer base that valued what it offered, bad seats and poor panel gaps and all (just like the GSM buzz and non-replaceable battery).

As far as the timeline, the slowness has surprised me a bit but I think comes down to a couple of things. One is the turn over time of getting a new phone vs a new car. Cars are much slower. And another (which might be related) is the price point of cars being orders of magnitude larger than phones. And finally, it's taken a good while for Tesla to ramp - it's been supply constrained forever (although there might be signs of that shifting).
Shameless plug on this topic: I've been working on a new Linux+Docker+Kubernetes solution for macOS recently! Already has quite a few improvements over existing apps including Docker Desktop, Rancher, Colima, etc: fast networking (30 Gbps), VirtioFS and bidirectional filesystem sharing, Rosetta for fast x86, full Linux (not only Docker), lower CPU usage, and other tweaks.

More details here to avoid spamming this thread: https://news.ycombinator.com/item?id=34374176
I have been doing federal taxes online for 10 or more years, using irs free file fillable forms:

https://www.irs.gov/filing/free-file-do-your-federal-taxes-f...

It does some calculations itself, and some you have to do yourself, but it is very easy to use and file online, and get a pdf return to save for yourself.

Any half decent state also has had free online tax return filing for some time now.
I am considering doing the same thing. Do you end up hosting it via Gmail or is there a provider that you go with? I am looking for something that doesn't have too crazy of a limit, have iOS/Android support and allows *@domain.name to go to the same inbox.
You get used to it. I went back to a nonretina 2012 mac as my daily driver. From 2 feet away, you can't see any pixels so it really doesn't matter much. Enjoy the increased performance from driving fewer pixels.
> "Is it really Coca Cola's fault your kids are fat?"

Yes. https://twitter.com/calleymeans/status/1609929026889711617

"Early in my career, I consulted for Coke to ensure sugar taxes failed and soda was included in food stamp funding. I say Coke's policies are evil because I saw inside the room. The first step in playbook was paying the NAACP + other civil rights groups to call opponents racist[...]The conversations inside these rooms was depressingly transactional: "We (Coke) will give you money. You need to paint opponents of us as racist.""

"watched as the FDA funneled money to professors at leading universities - as well as think tanks on the left and right - to create studies showing soda taxes hurt the poor. They also paid for studies that say drinking soda DIDN'T cause obesity."
The cult comment was in jest. These are just package managers don't take things so seriously, it is all in good fun.

Yes, I understand the multiple versions of the same package thing - Go/Rust have package managers that quite reliably solve that problem. Pipx also to a certain extent solves that problem.

Brew is useful mostly for casks (browsers, mac apps, fonts) which don't usually call for multiple versions.

I'm sure it is a hairy problem for some combination of languages/tools but I guess I'm somehow completely side stepping it. Perhaps I'm more likely to encounter it if I treated my laptop as a server because that seems more like where Nix might shine as a sort of ansible/chef/puppet on steroids ;)
Don’t forget air sealing while at it!
I haven't profiled the code, but I don't think better predictability factors significantly in the computed goto approach. Because of the global history table probably both sample implementations are likely perfectly predicted.

The advantage is that CPUs have an hard limit on how many taken jumps per cycle they can execute, as it requires resteering the fetch unit even before the jump is decoded. For example typically intel cpus can only take one jump every other cycle.

It is possible that the apple cpu in question has a tighter limit than the amd one.
Any Googlers in the team ?
I tripped on my usbc cord and broke the cable
Hi, I’m the guy who wrote the article. I had no idea it would spark such a conversation. A few points: apologies to the salty commenters who think I’m a snob or judging others. There is a paragraph in my piece acknowledging that “Yes, there are professional, commercial photographers who require more gear. But even many of them prefer simplifying their kit for personal projects.” I mentioned Peter McKinnon, who bought a Leica Q2 for this reason. The point of my article was to advocate for simplicity, and how limitations force us to be creative. Yes, I could use my iPhone (the quality keeps improving) but My Fuji/lens combo has superior depth of field and will accommodate better prints. I mentioned the Leica Q2 monochrome because it’s a compact full frame with amazing image quality, and because it’s monochrome, I’d be fully committed to black and white images. I like working with limitations and creating aesthetically unified work. On my travels I saw quite a few people juggling lenses, lugging backpacks. It seemed to slow them down, but if it works for them, great. I should have framed it better so as not to offend. I’m also a plain air landscape painter, and I saw the same thing. Artists with too much gear and weight. It took them forever to finally paint. I think less is often more, and that limitations can drive creativity. That was the thrust of my essay. In the end, happy shooting, whatever your approach may be.
You don't know how much a map costs to make, nor how much it would cost to maintain long term. Nor the cost of amortizing over 30 years. You're just making claims with nothing to back it up.

> LOL! Not even close to true. “We can do it” != “we can do it without burning billions of dollars per year”

"We can do it" = closest thing to solved. No one can say without a doubt we can do it for the other parts.

> How is that not deception in your mind?

You used "fraud". Fraud requires damages to a party. All the VCs have asked these questions and were given answers satisfactory enough to invest.

Here's a basic one they can tell investors: the top 10 cities for ride-sharing comprise 70% of the total market. It will cost $X to map and permanently have access to the vast majority of the market. We believe in addition, we can induce demand so this 70% of the market becomes a massive multiple of the current market.

If you're going to be this snarky, at least do some basic research.
That's possible, but the blog never claims otherwise. In fact it says "There are lots of ways to de-anonymize Tor users" so I think it's unfair to say Bruce is making unsubstantiated claims.
r/generative
I've realized there's a single simple thing that makes these dumb phones useless:

closed source.

That's right, closed source services.

If we were able to write our own minimal Messenger, Whatsapp, Signal, Viber, etc. clients without fear of getting a cease and desist letter from a trillion dollar company we could easily sideload them into any phone with an internet connection.

Phones are meant to be used for communication, but communication is not SMSs or emails anymore, it's a bunch of proprietary services which dictate what platforms we can use to access them.
First, as raincom mentioned, an expanding battery is a major concern. I'd recommend putting it somewhere fireproof immediately (such as in a metal trash can, or on a concrete pad), and making a plan to have the battery removed and properly disposed of in the near future.

Running the battery down to below 30% might also be a good idea, but only after it's somewhere fireproof.

Edit: here's some more info: https://www.reddit.com/r/spicypillows/comments/gebotv/faq_wh...

To answer your question, though, I've learned from iFixit guides, youtube videos, just taking things apart and tinkering with them, etc. Apple uses some oddball screws sometimes, but you can get a toolkit with everything you need for $30 or less.

I'm more of a software guy, but I mess with hardware occasionally. (I'm also willing to pay a professional if I feel like it's over my head.)
If TSLA needs a bailout in the future, I say we just let it fail. This company is just fucking terrible. It has turned me off from EVs completely. From the terrible build quality to multiple failed deliveries, it's just not worth it anymore.
I use the slightly older 14” macbook at work and since I’m always in different meeting rooms, and only at my desk for half the day I charge it like I charge my phone. If I notice it’s low, I charge it when I go for lunch or whatever.
What a great story! I remember also "hand running" programs at times.

While the Dec 77 issue of Byte[0] had Star Trek on the cover it didn't contain a BASIC listing. Could it have been either the May/June 1975 issue of Creative Computing[1] or one of the compilations (BASIC Computer Games[3])?

[0] https://worldradiohistory.com/Archive-Byte/70s/Byte-1977-12....

[1] https://archive.org/details/CreativeComputingv01n04MayJune19...

[2] https://archive.org/details/Basic_Computer_Games_Microcomput...
Section 702 is up for renewal soon. I don't think it is a coincidence Bruce is bringing this particular case now. It seems like he is trying to add fuel to the "repeal" fire.
Then you have a poorly configured bullshit detector. Second hand smoke was studied in depth, and plenty of children have ended up with health problems from their parent's smoking. It is only a "controversial" fact among people who refuse to give up smoking for the benefit of their families.