skysight-inc/HackerNews huggingface dataset:
Antihistamines are often large ligands and tend to have other neurotransmitter affinities beyond just histamine receptors, chlorogenic receptor affinity is fairly common as well. They’re extremely powerful drugs with incredibly complex side effects. It surprises me that modern medicine uses them so casually, though thank goodness, as easy availability does allow for bypassing the gatekeepers. Just people should know they can make themselves quite sick from it, though if you’re sick it could make you better.
It is up to Khronos to make it more interesting to do otherwise.

Hardware Transformation and Lighting, CG/HLSL, RayTracing, MeshShaders and more recently DirectStorage, are all examples of features that appeared first in DirectX, with AMD or NVidia hardware implementation, before showing up as OpenGL or Vulkan extension.
Several high-profile Sri Lankan targets, including its defence and education ministry, were listed on a data breach post
There is this additional post:

“Someone who works at Meta reached out and advised me to rename the filters asap.” [1]

So maybe the issue is simply that Pixelfed is using identical filter names.

[1] https://mastodon.social/@dansup/109596825332511647
It exists, and it's very good.

https://en.amarahasa.com/
I wonder if these people have immunity to malaria and other types of rainforest diseases.
This is the model of university I like to proselytize. It's similar to "The University" in The Name of the Wind by Patrick Rothfuss, but I was thinking about this concept before I read the book.

The true quality of a college education can be measured by two questions at the end of your degree:

1) What do you know?

2) Who do you know?

How many hours you spent in class, how many labs you did, how much you liked or didn't like your professors, what your assignments were--none of this really matters once you're out of school, as your real-world performance is the only advertisement for the quality of your education. A university is technically only in service of stuffing information and skills into your head and people into your professional network.

A university that holds exams perhaps once every four months, that charges only to take an exam or pay-as-you-go lectures, and is built around a come-and-go learning method would add an incredible amount of freedom and flexibility for adults. You could take ten years for a degree, one year for a degree, or cycle in and out of "college" for your entire life. Lecture models would be built around the exams, with private tutors charging for preparatory courses or attached lecturers charging for full courses.

I think that modern college has become an identity-based lifestyle that holds young adults back from participating in greater society and excludes older adults from returning to education. Changing to an open university model would allow for more exchange of information at quicker rates. Furthermore, the enormous transient population of learners would need to be supported by the surrounding towns, which could easily be staffed by people attending or who already attended "college", but are unencumbered by class schedules or homework assignments.

Most of the other benefits that colleges offer--research, socialization, extracurricular clubs and societies, music--could be easily offered by voluntary societies that exist near the colleges.
information and art should be free, and authors and artists should be entitled to decent living
Discussion? Yes, in the usual token sense. But not much more. And if amything it was directed solely at Trump, not the USA's long standing (hypocritial) relationship with SA. That's simply not something the USA MM does.

Regardless, it's one example. The point is, the Western Media is relatively blind to anyone or anything that involves itself with SA. RT probably does a better job.
I feel like this is part of the problem, we keep trying to find the right abstractions, but it seems to me the ones that generalize well enough are tend to be very difficult for most to understand.

I've been down a rabbit hole for the last five years researching this, and I am converging on Clojure. I don't understand why transducers aren't used everywhere, they seem to solve a gigantic class of problems that I see everywhere.

I'm also getting the feeling that Haskell folks have really done a lot of great work, and plan to learn more about their typing system next. Monads seem to be a fundamental building block.

If I try to bring this up with engineering teams, I don't get any traction because nobody wants to learn any of this stuff. It takes too much time to ramp developers up, and management is skeptical because there aren't enough large-scale communities or companies built around the concepts from their perspective. Bottom line is, it takes too much investment for too much risk.

Instead we get a lot of half-baked and wrong abstractions incrementally invented for the latest pain point instead.
You can’t invest in much of Vietnam and its biggest businesses due to regulations banning foreign ownership.

Look into closed-end funds if you want to better approximate what a real index of Vietnamese businesses would look like.
You can buy old academic e-books for exorbitant prices? Are you not perhaps thinking of physical copies of out-of-print books?
I always buy physical book.
>I am looking for desktop only.

>I have already yak shaved down to the level of writing my own windowing framework.

>Qt, GTK, Wx, etc. are all too complicated (...) I dislike their application frameworks, and I don't want to use their widgets.

>Bugs in Skia or GLFW or drivers or what-have-you are frustrating and blocking.

I'm subject to similar simplicity and dependencies-averse tendencies, and made that:
https://github.com/jeffhain/jolikit/blob/master/README-BWD.m...

PS: I've been building a toolkit on top of that, which I use for a file explorer/editor, but it's not stable yet, still many little design points to think more thoroughly.
What’s really fun is you can upgrade the SE/30 to 128Mb
I thought this had been common knowledge for years.
The "right people in government" are the ones doing it in the first place, alternately pictures exist of them doing naughty things, and a dead hooker can always be "found" in their trunk. Epsteinyay idn'tday illkay imselfhay .
The article mentions this. If you're using a regex engine that isn't susceptible, people will still report ReDoS vulnerabilities against your project.
While I don't agree it's a Spendesk problem, it's definitely a hard position to take that Spendesk shouldn't fix it themselves. When a large (I'd guess, at minimum, double digit) percentage of your virtual card traffic goes through Amazon specifically, having your product trigger Amazon's fraud detection system, however broken it is, isn't a great look, and borders on being a bug. At the end of the day, the customer doesn't really care whether what Spendesk does is perfectly reasonable - they only care if it works.

We have some other examples of this in software:

* There was an article here on HN a couple of days ago, regarding how Windows 95 detected SimCity and treated memory allocations differently if it was running. (https://arstechnica.com/gadgets/2022/10/windows-95-went-the-...)

* Excel still treats 1900 as a leap year, which it was not, for greater compatibility with Lotus 1-2-3. https://learn.microsoft.com/en-us/office/troubleshoot/excel/...

* The Linux kernel has an extremely strict policy of not breaking userland - to the point of keeping buggy behavior in place (I can't find a reference for this one, but I believe it one notorious case involved PulseAudio and one of Linus's earlier "moments").
You are not making a whole lot of sense in this thread.
The planet isn't dying, more C02 will likely mean more greening of the earth. We could do to sort out the plastic waste though.
Kindle devices support epub now, don't they? Aren't they deprecating .mobi?

If you use an Amazon account you can email them to a specific email address to get them on your device.
That question and more answered here: https://breckyunits.com/an-unpopular-phrase.html
Except for the part where Amazon (software) agents break into your home and steal your books.
Reminder: Amazon once secretly remotely wiped 1984 from people’s kindles.

https://gizmodo.com/amazon-secretly-removes-1984-from-the-ki...

You don’t actually buy digital books, you rent a restricted right to read for an unspecified duration. I think there should be legislation that sets a minimum standard for the rights people acquire when they “buy” a digital work.
> I guess now that SA has signaled a slight shift away from the US empire, we're going to be seeing a lot more articles about how evil they are.

Telling that the gist of the article isn't "These people are suffering from slavery" but rather "These people are selling slaves" - the focus is on the Saudis, not on the slaves. Unfortunately, slavery is rampant the world over even today. My own grandfather was a slave.

But this is not a piece intended to help the slaves. This piece is intended to slander the Saudis.
> all times

How do you explain World wide web and sqlite? They are 100% public domain.
kindle handles epub books just fine (not sure how recent that is).

They also provide an email address where, if you send an email with some epubs attached, they make them magically appear on your kindle.

I was pleasantly surprised by this last week, since I got a kindle and I thought it was going to be a hassle, but nope.
You will be surprised to learn that Human Trafficking is a global problem including in America and is lot more than 1 or 2 isolated incidents.
Nice idea.

The color for links seems to be the default in most browsers: blue for links and purple for visited links. These colors are extremely hard to read against the site's background color. Are you able to style links so they are easier to read against the site's background color?
For those of us with, like, day jobs, can someone summarize what damning discoveries were actually revealed in the "Twitter Files"?

My impression is:

1. These "independent journalists" like numbered lists instead of prose (OK?)

2. I find numbered lists a bit hard to read.

3. There's no headline or lede that suggests...anything? But I keep reading the numbered lists out of morbid curiosity.

4. At some point it's revealed that, shockingly, an American tech company was in contact with American government officials.

5. Those officials spoke to the tech company about known or suspected foreign influence operations that might affect that tech company.

6. The tech company expressed gratitude for those tips.

Like, honestly, isn't the reason the "mainstream media" hasn't reported on this because they're in the business of reporting on things that their viewers would find interesting, and this is a super boring story?

Yes, if you name anything "the [something] files" and label it "suppressed knowledge now come to light", it sounds sexy. But is there anything actually significant here? If so, can someone summarize it for me in a numbered list?
So if jcs somehow gets banned, the whole place shuts down?

I find the idea of the site intriguing yet I'm not sure what I could contribute.
Read the Osho Zen Tarot book as a departure point to find your own questions, pending conversations, unsolved issues, and wished next steps.
LOL, people who get cancelled get their bank accounts and credit cards and exchange accounts shut off, and are completely exiled from modern society. They can't complain about it either because they're banned from all social media. All of the above happened to me!

You obviously sympathize with the mob destroying people's lives to trivialize the effects like this.
> Amazon doesn't have a shopping card for kindle books

I don't know what this means. What is a 'shopping card for kindle books'?

EDIT: OK - thanks all. Likely a typo of 'cart', unless the OP explains further. That was an initial thought, but the next line mentions 'so for each of the purchase I created a new virtual card and bought them'... so wasn't sure what the 'card' connection was.
Distributed Tracing in 2025
Actually Sarbanes-Oxley was passed because big corporations that were decades past IPO defrauded people. Frauds at IPO were already covered under other legislation and were rare and easily prosecuted. It was WorldCom and Enron (among others) that lead to this legislation not IPO scams.

Arguably you could achieve the same results (auditor independence, senior management accountability) without any change to how small public companies behaved. Enron and Worldcom could bend auditors to their will because of their size, <insert tiny company worth under 10mil here> already could not do that. Why not have the requirements scale with size then?

Personally I think Audits will continue to be worthless until Auditors are required to have some "skin in the game": if an auditor signs off a company's accounts and it turns out there was a mass fraud or bankrupt, the auditor is civilly liable for at least some percentage of the loss. That's no different to how rating agencies should also have been reformed. "If you want to know how risky something is, don't ask a 'consultant' paid by the guy selling it, get an insurance quote".

As it is, these things are always trade offs: is it better to lose $1bn in fraud or spend $1.5bn in extra accounting and investigation? If new rules remove 2 frauds but also prevent 200 companies going public is that better or worse? If the US brings in rules and companies just list on other markets and the same investors get defrauded, does any of this matter? And how does anyone even measure the "what if" scenarios with any rigor to inform our decisions? It's not (IMHO) a solveable problem...
Never heard of Pixelfed, but it's sort of shady that, the moment they received notice that they shouldn't be copying a trillion-dollar company's product 1:1, they immediately cry that they need more donations.

Just rename the filters, and maybe make tweaks so they aren't exactly the same, and then suddenly Meta has no standing.
There is a 3 part course on Coursera by U of Washington Prof Dan Grossman called

Programming Languages A: https://in.coursera.org/learn/programming-languages

Programming Languages B: https://www.coursera.org/learn/programming-languages-part-b

Programming Languages C: https://in.coursera.org/learn/programming-languages-part-c

It will surely make you a great programmer if you haven't dabbled with functional languages before. Even if you have, it still makes a great course only for the teaching style of Dan.
I also like the Kindle purchase experience. I usually put a sample in the Kindle, check it out, and then with a single click I can have the full book in minutes without going to my computer or phone.

Calibre provides a very good service, but it can be a bit puzzling in terms of UX, also getting certain pirate books is a big chore and might require visiting dodgy sites. But the reason I stopped downloading books is that I often ran into small issues, like footnotes or a table of contents that didn't work correctly. The last book I remember downloading was "Thinking Fast and Slow"... I ended up purchasing it on Amazon because every half page it had a word duplicated, with the duplicate slightly scrambled srcambled. It was maddening... probably planted by the author , Daniel Kahneman, as a psy-ops DRM device.
This sounds so stupid. Imagine if the inventor of first button had sued others for copying shape and it's shadow
Funny, considering how instagram just straight up ripped-off tik tok with instagram reels.
Vietnam might look small on google maps, but it actually almost as big as Germany and weather in south is very different from north. I understand that a lot of people live in Hanoi and Ho Chi Minh, but there are certainly places that are quite close to some island tropical heaven.

I spent plenty of time living around Phan Thiet, Na Trang and Da Nang next to the sea. While it generally humid in many places there is barely any rain outside of rain season.
U.S. Champions of High-Speed Trains Find Adoring Fans – 7k Miles Away
BIMI authentication is a brand new weapon against spoofing. Looking for a friendly guide to set IP up? We’ve got everything covered for you.
That's a "failing" of Amazon, not of piracy. It benefits them to make it inconvenient to put things on it manually; it encourages you to use their store instead. The Kobo supports ePub natively.
It doesn’t fit in this discussion, unless you want to use one repellent practice to justify another repellent practice.
People running bug bounties at least get paid to put up with this garbage.
The Vietnamese are very intelligent. You never know what they think.

The Russian ones who help them, "come and give us their money. We are all Communists. Chinese give us guns. We are all brothers."... They hate the Chinese!

Maybe they hate the American less than the Russian and the Chinese?

I mean, if tomorrow the Vietnamese are Communists they will be Vietnamese Communists. And this is something you never understood, you American.
Just like Snowden's revelations?
In what ways are quality of life inferior?
The vibes are off at Tesla
Great YouTube channel. Here’s a fun video where he integrates a raspberry pi into a NES cartridge to do all kinds of crazy things using the NES’s native hardware. Spoiler alert: full-motion video of the rickroll video is not the craziest thing he manages to pull off.

https://m.youtube.com/watch?v=ar9WRwCiSr0
Ehhh... OP is riffing on a theme that's been playing a long time.

Back around mid aughts, it was pretty easy to pirate movies. Doesn't really matter how but it wasn't hard (still isn't actually, but that's beside my point).

At the time I was still avidly collecting physical media, and I observed at some point, as did many others, that it became an absurd choice of getting an xvid, double clicking, and there's the movie, vs. load the DVD, sit through previews which, even if skippable, just no. And then the warnings of course, which again, sometimes skipping or fast forwarding would be disabled again.

So your reward for playing by the rules was wasted time looking at or skipping - forever - the marketing for whatever garbage they had coming out that season.

I understand that not everyone wants to embrace the Cory Doctorow professional model, but I sure don't mind giving him my money.
> Service time is how long it takes to do the work.

> Response time is the amount of time spent waiting before the work starts.

Is that right? I thought response time was the time from user input to completed response.

I'm not sure (I found parts of the article hard to parse), but I got the impression that author's generator won't generate a new request until the previous one is complete. That's not how I'd write a generator.

Also, it seems odd that the test-rig would discard responses that arrive outside of the test window. Surely it should record all responses to requests that were emitted during the window, even if they arrive outside the window?
You missed the point. That is, they are not the only ones. In fact, the whole country (read: US fed gov, and perhaps plenty of states) are in bed - comfortably - with SA.

But as long as they have oil, and we need to kneel before them, our media plays along.

Note: This is not a critique of SA. They're a sovereign nation. I'm not fit to judge (and it's off topic). This is a critique of Western media and it's willingness to look away.
It's utterly predictable and depressing how the left (of which I'm increasingly embarrassed to admit I'm one) have moved immediately to dismiss the revelations - which we would not have had without the change in leadership - as a "nothingburger"

Extraordinarily negligent or baleful of the mainstream press to try and bury this as well.

For years right and centrist claims of bias and censorship in the defacto public square were dismissed as conspiracy theories, and warnings that a change in leadership would carry the risk of equal partisanship the other way glibly dismissed.

Depressing.
'have' denotes property, slaves are property. It just jumped out at me.
So far nobody was able to get such model unless I missed something. And the whole point of the decoherence exercise is to avoid Born rule as it implies a truly classical subsystem and we are back to where we started.
> You don’t actually buy digital books, you rent a restricted right to read for an unspecified duration.

Which is fine, as long as you know that going in and set your price expectations accordingly. If those terms are unacceptable, walk away. If you do decide it's worth it, keep a backup with the rest of your digital data.
z-lib is still up on Tor. Check wikipedia for the links.

You do need to login with an email though which sucks.
It’s not the matter of CPU arch, raw performance or even power consumption.

“640KB of RAM” is all you ever need in a great range of use cases that isn't currently well explored, and ESP8266/ESP32 serves that market very well with Arduino IDE integration and affordable devkits.

e: added absolutely necessary positivity to languages, sorry!
Ask HN: Optical Lens Software?
Hi everyone, are there any free software or sites for calculations or simulations related to optical lenses and parabolic mirrors/reflectors?

I would also be interested in any collections of formulas (with explanations of their uses) for these purposes. I have found some, but not enough to do these calculations on my own.
I don't think that's true for most people, but for me the difference isn't large enough to matter.

It probably takes most people 1 or 2 minutes to click the one click buy button on Amazon and download a book. I can get a book from Z-Library on telegram, upload it to Dropbox, and have it downloaded to my Kobo in 3-4 minutes -- not a big deal on book reading time scales.
This is pretty great. I've often wished for the concept of LLPSI in other languages, I'm glad someone is doing it.

Also, I should try working through LLPSI again.
Authors aren't benefited by second hand sales.

Have you considered libby? Nowadays libraries around the world provide you with an account that gives you access to their catalogue for free.
Sorry,

Vending people hated it, he explained to me, this unexamined expectation of mechanical failure.

The same meaning far as I can tell. How can anybody doubt that vending machines suck? With the mountain of experience and anecdotes. Hardly anything has been more examined, has had so many failures as to to build an expectation.

Once burned; twice cautious. Or 100 times cautious in this case.
Yes. It's not different from people opening git issues for small things. It's exactly like that Digital Ocean "Hacktoberfest" thing, which incentivized people to submit bogus PRs in open source projects to get swag, forcing open source maintainers to do the labor of sifting out the (voluminous) chaff.
This is what I do with my base model Kindle. I have its email address saved as a contact so it is super easy to send it ePubs (or PDFs!) from my phone.
It's a terrible design. A Scandinavian auto magazine that I can't recall the name of did a test this year, and found that touch screens are across-the-board more distracting than physical pushbuttons. Which is obvious to anyone who's ever driven a car and used touchscreen buttons, but sometimes it's nice to have hard figures to back up the obvious.
> Never heard of Pixelfed,

You may not have but that community is actually very active. I posted 5-6 photos on pixelfed and it had more engagement than my total Instagram engagement over 5-6 years.