skysight-inc/HackerNews huggingface dataset:
Genesis Therapeutics | Burlingame, CA | Remote or Onsite | Full-time or Interns | https://www.genesistherapeutics.ai

We’re a hybrid AI + biotech start-up, developing novel deep learning and molecular simulation techniques to predict molecular properties and using them to accelerate the development of new medicines.

We raised a $52M Series A from Andreessen Horowitz + well-respected biotech investors, and have deployed our technology on several internal drug programs as well as multi-target collaborations with Genentech + Lilly ($20M up-front revenue + $670M potential total value), driving discovery progress at a speed rarely seen in the industry. Now we are scaling the team and technology to support many more drug programs in parallel as well as increasingly difficult protein targets.

We currently have a team (https://www.genesistherapeutics.ai/company.html#team) of about 40 people, split 50/50 between our ML / software team and our biochem team of veteran drug hunters in our own wetlab space. Our ML + software engineers are top-notch -- many graduates from MIT, UC Berkeley, Stanford. Previously worked at OpenAI, Google, Facebook, SingleStore, Jane Street, etc.

We're looking for pure software engineers (no bio or chem experience expected) to help build flexible production systems to integrate our ML models, molecular simulation platform, and molecular generation techniques into our drug programs. This includes helping build individual algorithmic components, iterating on our chemist-facing model deployment pipeline, and leveraging our autoscaling cluster of thousands of GPUs and tens of thousands of CPUs processing billions of molecules / day.

We're also hiring ML research scientists and computational chemists. Here are all of our open roles: https://jobs.lever.co/genesistherapeutics/

Interview process: 1-2 one-hour technical phone screens, 1 day on-site (optionally virtual) with 3 one-hour technical questions. All these include extra time to chat, answer your questions about Genesis, and meet us. Can go from first email to offer in 2-3 weeks

Tech Stack: python, pytorch, postgres, flask, kubernetes

Please apply on our website, or feel free to reach out via email directly: ben@genesistherapeutics.ai
Galaxy Z Fold 4.

The S22 ultra has a better set of cameras, but I needed the foldy tech to have a portable tablet.
Where's the personal attack?

I suspected that you had a certain view, so I prompted you to clarify your view, and you did indeed clarify your view:

> Sure, years of life are lost, but what kind of years? Someone in an old age home near the end of their life dying isn’t equivalent to a young child dying.

By your own words, you devalue the lives of older people.

I think it was good for everyone to see what you really believe, but I don't expect to be able to change your mind, so there's nothing to argue.

The only "personal attack" in this thread was:

> You’d make a poor healthcare statistician getting upset over words like that.
Pattern recognition does not seem to be a forte of yours.
I'm tired as well so I understand ;)

Windows XP was nice, yeah. Windows 7 as well, and I can tolerate Windows 10 for gaming. For everything else, the penguin does the job.
S22 ultra, specifically telephoto lens #2, is 10x

https://www.samsung.com/uk/support/mobile-devices/check-out-...

10MP F4.9
[10x, Dual Pixel AF], OIS,
FOV 11°, 1/3.52”, 1.12µm

Its #4 in the graphic.

Space zoom is 10x on top of that.
The reason why labor received more rights in Europe after WWII is that the rulers were worried about labor following the example of the Soviets. Carrot pre-empting geopolitical problems.

As soon as the Soviet Union went away, the negotiating power of labor started to weaken.

The statements above are not to be taken as an endorsement of the various kinds of genocide and horrors Communism created in the places where it ruled. It is just an observation that power, or the implicit threat of applying it, is what rules in the end. Lots of words are used to cover that raw reality.
I think you probably can start using svelte/sveltekit for production development, depending on your timeline... the "svelte" part is mature, and sveltekit (the web app framework around svelte) is close to release according to their status report (feature complete, no more planned breaking changes)

It's a little risky, but not particularly so.

But I agree that vue3 is usually a much better migration path from vue2. Also, it seems outright bonkers to me to give major weight to the "State of JS" survey, and doubly so since the delta is small.
Honestly even dry changelog is better than what most popular apps are doing right now (copy-paste "fixed bugs and improved stability" x10000)
Please don't abuse public good infrastructure
PSR is far more then that, but this author doesn't care to go into that since it detracts from his or her argument.

From wikipedia:

Precision railroading or precision scheduled railroading (PSR) is a concept in freight railroad operations pioneered by E. Hunter Harrison in 1993, and adopted by nearly every North American Class I railroad. It shifts the focus from older practices, such as unit trains, hub and spoke operations and individual car switching at hump yards, to emphasize point-to-point freight car movements on simplified routing networks. Under PSR, freight trains operate on fixed schedules, much like passenger trains, instead of being dispatched whenever a sufficient number of loaded cars are available. In the past, intermodal trains and general merchandise trains operated separately; under PSR they are combined as needed, typically with distributed power. Inventories of freight cars and locomotives are reduced and fewer workers are employed for a given level of traffic. The result is often substantial improvement in railroad operating ratios, and other financial and operating metrics; at the cost of less-reliable service, particularly to smaller customers, long-term capacity issues, increased derailments and other safety risks associated with longer trains, and crew fatigue.

PSR is the reason why half of the US rail fleet is in storage, they are no longer needed. this has significant positive and negative benefits. On the positive side, this includes the environmental impact, on the negative side, it makes US rail systems totally unusable for anyone other then the freight railroads.

Freight railroads (and rail in general) remains one of the most regulated business out there, but the rail companies are aggressively pushing back on new regulations that would address significant problems.
Sony still makes many smartphone sensors. And optics? Not sure.

They just don't get to put their name on the resulting "camera" in this new world.
https://web.archive.org/web/20221030055243/https://help.twit...
A blueprint for algorithm discovery with reinforcement learning
Enhanced weathering experiments indicate that slreading basalt dust over agricultural land in quantities roughly equal to iron tailings (a large portion can be thise exact iron tailings as it is often basalt hosted) would sequester 1ppm per year whilst improving yields. It is not enough to offset current activity, but it is enough to bring levels down to something less bad in fairly short order.

This is just one of many possibilities.

The last resort one is iron seeding the lowest-life portions of the pacific. It is proven to work at many times higher scale for much lower cost, but the potential harms are not yet fully understood.
I use Nix on macOS to install emacs. No special ports.
"such as just being rude and flippant on purpose"

How is that not trolling?
As if it's unfathomable that preventing gains by groups seen to be competing with a groups interests could be an interest in and of itself.

The groups interests were not correctly understood. The progressive course when this happens would be to attempt to improve understanding of the groups interests. Alternatively, you can keep the invalid assumptions, disproved by the groups behavior, and assert the group is illogical and harming itself - at this point you're no longer reflecting on reality.
The post title contains a spurious "and".
This is missing the point of the meme. The point is that the phrase “nobody wants to work” is a meaningless constant refrain that goes back decades. It’s not new, and it’s not true.
It's TEEtime: Bringing User Sovereignty to Smartphones
I actually love the url; it's endearing.
Are they able to go elsewhere and find better pay?
Apparently that means challenging each individual provider, and you must have tried to sign up with them and failed for them to take you seriously?

Sorry, FCC, this map is less than worthless.
The issue is that the recent growth in the software field has caused people that would otherwise major in something else, and aren’t really interested in software, to be your coworkers and they don’t care about doing a good job. There are some areas of software which would be benefited (lower cost over time) to apply an engineering mindset. That’s not what happens with agile. The whole ethos is about being able to change the design around, shipping MVPs and quick iteration. In hardware it has to be correct when you ship it , leading to a more methodological approach. As a result, some software work in comparison to hardware work can come off as sloppy.
Majority of shipping/trading documents are formalized under EDIFACT standard
for example, this is the layout of Bill of Lading/Shipping Instruction, so called IFTMIN https://service.unece.org/trade/untdid/d04a/trmd/iftmin_c.ht...

One of the possible reasons for TradeLens demise is that they choose to ignore them and came up with their own data structures (Json) i.e. partners that are usually EDIFACT capable had to practically start from scratch to comply with TradeLens format.

At some point TradeLens realized that and started partially accepting EDI feeds, but it was too little, too late I guess.
In my experience I recover low level storages (think dd or lower) in consumer and professional cameras, and cell phones.

I still find errors in FAT32 implementation when it comes to cameras, while phones have moved on to get specialized formats depending on the storage chips' design.

Cameras' firmware are decades behind.
This is your regularly scheduled PSA that day trading is essentially a high-effort casino and <1% of day traders make money reliably.

https://www.youtube.com/watch?v=qhHOmZVAqBE
That's most of Enterprise application dev as it is. We can have that run by robots and have actual people do things that actually matter.
We can have a discussion about what sort of speech is unacceptable on a social media platform. My concern is largely with the people who insist that we shouldn't even have the conversation about insulting messages because of free speech absolutism or whatever.

The "oh but lefties are mean too" argument immediately retreats from the idea of free speech absolutism. I'm down for that.
Not even "maybe not", rather "definitely not".

The issue is not people working or not working; The issue is the distribution of power. If it's not a problem of the people in power, then it won't get solved, easy as that. This is not something that can be solved on the individual level, because due to the population numbers, we now exist in a huge, global, interconnected system of societies, governments, and such. And these issues, at the end of the day, could be solved by evolving, changing that system. And the individuals follow, as their incentives dictate.
I take at least a month of unlimited. Many people just assume the world will end if they take a week off
Sure, you're right about that. It's just that everybody, for example, has the option to use React.createElement directly without JSX, as it's just a syntax sugar and people use it because they prefer it over the other option. Let's consider Vue's syntax:

<template v-for="todo in todos">
<li v-if="!todo.isComplete">
{{ todo.name }}
</li>
</template>

Genuinely, do developers have the option to "just use JS" here (for looping and conditional)? I personally think this Vue example is very inferior to JS and I see it as an unnecessary complexity unless this "weird string magic" is what enables some nice-to-have feature which is not possible with plain JS.
>I'd tend to lean toward CC debt

I think I would lean toward household mortgage. The reason is simple. With a quick (and admittedly superficial) search, the average minimum credit card payment was $110, while the average monthly mortgage or rent payment was $2100. Despite the fact that many people don't have mortgages, they still need a place to live, and you can't decouple rent and home prices. Which is particularly pernicious for renters because their home costs are not fixed. Add to it that many people use their home equity as a revolving credit line and I don't think the costs are as fixed as one might first assume.

I think an underlying issue is that people have an optimism bias in terms of budgeting. They live riiiiight up to their level of income. I think the stat goes back at least a decade, but something like 65% of Americans cannot afford an unforeseen $500 emergency. Some of this is attributable to wage stagnation, but I also think much of it is due to another type of inflation: lifestyle inflation.
MLabs is Hiring Project Managers and Delivery Managers!

We are one of the leading Haskell consultancies in the fintech and blockchain with a passion for Haskell and open source software. We’ve been around for 4 years and have grown to over 100 people!

We are now looking for a remote Project Managers and Delivery Managers to join our team, on a full time basis. For full job descriptions please visit: https://apply.workable.com/mlabs/j/12604820A9/

Requirements:
- Knowledge of the Blockchain space, Cardano in particular
- Understanding of current and upcoming industry developments
- Experience in writing and good understanding of Haskell
- Outstanding communication and leadership skills
- Attention to detail
- Team Leadership experience and project management experience are both beneficial

Benefits:
- Fully remote work in your timezone at your schedule
- Focus on learning and individual growth
- Work with other great open source contributors and computer scientists
- Interesting and challenging projects
- Competitive salary
- Employee token fund for bonuses, travel, conferences
- Flexible working hours
- 6 weeks of paid vacation

Please apply via: https://apply.workable.com/mlabs/j/12604820A9/

If you have any questions please contact jobs@mlabs.city
Nobody wants to write a full comment anymore and leaves trailing sentences.
That's exactly what I thought!
Everyone I worked with had a undergrad is CS/math/engineering and plenty had masters / PhDs. That's generally what the profile of devs at faang looks like. I'm sure there are some people who have different backgrounds but it's not common.
Your statement

> "we all gotta eat" is […] root cause of a lot of ills in the world today

hits the nail quite well I think. People are forced to generate income, even when that is to the detriment of other people or the environment. Natural resources are exploited without restraint, factories keep producing incompatible, low quality electronics and online services that harm mental health but create a profit are pushed onto markets with great vigor.

But with the advent of machines of human-level ability (physical & cognitive), within the next decade, human labour will not be competitive any more. This provides us a unique opportunity to overcome the traditional compulsions of our current growth-fixated economic framework and transition to a steady-state, cooperative economy (aka RBE) instead. That means leaving behind barter trade and local optimization for individual or company profit, paving the way to a good life for all, without time pressure and compulsory work.
We (Open Source Ecology Germany) are actually working on getting funding (via PrototypeFund.de) for a cooperative economy simulation game.. To make it easier for people to imagine a post-capitalist economy and to start working on rules and organisational mechanisms for such a society. HN is invited oc ; )
Swift is what you are looking for then? It has same goals as Rust(the original creator of Rust is(was?) working on Swift).
Wise choice, but it brings along with it the curse of Plato’s Cave.
I too have a background in Mechanical Engineering and while many software products are complex I wouldn’t categorize all of them as engineering projects in the historical sense of the word. That’s not to say there are not quality software products that satisfy real businesses requirements. But it is to say that a lot of software projects would be WAY too expensive if they were engineered the way a passenger jet or a skyscraper was engineered.

The software development field is quite new compared to the other engineering disciplines and many, many decisions are made on gut feel, intuition or out right personal preference. Alan Kay has some very good talks on this specific subject, referring to the current state of our field as a Cargo Cult.

However, I would also say firmware would be the least expensive to engineer because the requirements for that type of software are better known and more rigid.
The venues have a lock-in with the Ticketmaster monopoly, so she - and every other artist, such as Pearl Jam in the 90s (as described in the article) - would still need to go through them
No, I'm not. If you have supporting precedent for your position (that a licensor can be held liable for the unpreventable actions of a licensee) I would like to see it.
Backwards compatibility is overrated, sticking to it too hard is how we get stuff like JS or C++ that have ten different ways of doing the same thing. I'd much rather a language be improved and break sometimes than to convolve around keeping strict BC. Anyway, they have good BC support since Dart 2 released several years ago so I'm not worried.

With your Java example, that's exactly what I mean, you don't need 4 different tools in Dart to achieve the 4 types of compilation, they're all included in the standard Dart compiler/SDK. Sure, if we go by your definition, probably any language has some level of support for each via various random compilers but I'm talking about something first-class, built-in.
It's not a problem with camera manufacturers, it's a problem with hardware companies.

Even chip vendors, who you would would think understand the importance of software, will de-prioritize their software side.

I wonder if it's a sort of macho thing; anyone can learn to write software, but not everyone can get an EE degree.

It also could be that the idea of incremental releases doesn't really exist on the hardware side. Hardware, because it's physical, requires a coordinated release. Then you do the next revision once the inventory gets low. The idea that you can ship on a flexible schedule is alien to the hardware side.
As someone else said, Nintendo is the company that publicly restarted the new Metroid game development because it was not up to their standards.

They seem like the company that will hesitate the least to push back a game. Partially I assume because they know that no matter when it releases it will likely sell well, but also because of their reputation.

I can't think of a rushed Nintendo game in recent memory (outside Pokemon). Nintendo sets a pretty high standard for game quality across the industry.
The problem is the scheduling side of things, not the PTO side.

For "knowledge workers" as most of HN is, they can just not show up today and then do today's work tomorrow. But something like a railroad ceases to function at some point and that has severe repercussions.

Now likely the "railroad" problem could be solved with some work, imagine a nation-wide company that handles railroad staffing emergencies, with on-duty employees available to go to a stranded train at a moment's notice. There's some dollar amount this would cost (even if you utilized jets and helicopters, those are just a cost) and it'd work. But that cost is what the railroads don't want to pay, as they could also do the same thing by hiring more employees (and have some percentage of them "idling" at any given time).
Yeah this is accurate of their situations. Very little savings, no retirement. But I will say, alot of them are early 30s now and have fulfilling lives and good relationships/friendships. They have developed themselves along avenues that are hard to do when working full time. Really makes me wonder
Not new. Alex Jones is off just because he says so.
It's a shame that Future.com didn't pan out. I could care less what people like Kara Swisher or anyone at The New York Times [1] thinks about technology or the companies changing industries. The only people who seem to write are activists.

[1] https://news.ycombinator.com/item?id=33456708
I don’t think those are incompatible. If Michelangelo designed a paperweight, it would probably be a magnificent paperweight, while still just being a paperweight. (This is an extreme example, Mergesort is better than a paperweight).
"Kin" is a pretty common prefix when going between film and video: https://en.wikipedia.org/wiki/Kinescope
That exists, the Sony QX100. Nobody bought it because it’s not quite as good as a real camera and it’s something you have to remember to bring with you.
A solar map that marks areas with dense forest as having the same generation capacity as areas with open grasslands? Yeah, I would call that bullshit too.
Content-wise it's among the best gens IMO. My heart breaks for the creative team that's held back by their tech.
She might not have $10-30m liquid sloshing around her couch cushions.

And even if the problem were fixed for TS events, what about all the other ever present ticketmaster rip-offs?
The title should point out the verse was written by chat.openai.com.
The day in 1982 when the world wept for Algeria
I assume all Nintendo cares about on release is "does it pass lotcheck". It technically does, so...
Day traders work way longer hours than that, the clue is in the name. I think your friends are you just BS'ing you about where their income comes from. The amount of "day traders" who are just wealthy gambling addicts who in reality lose money long term is too damn high.
lol completely agree. there is ample clear evidence you're a scumbag liar yet you continue to create imaginary evidence that you're actually a good person.
Software developers also get all those benefits. Whenever people talk about how terrible working in the US is- almost none of that applies to software. You get plenty of time off, sick days are a non issue, work remote if you don’t feel like going in, health care insurance is free/cheap and good, etc
Regarding your last question, Quantum Bogosort Chinese to mind. Don't know about classical algorithms though.
And just like buying a house - despite the asset being collateral for the loan and generally having net positive equity, the individual is personally incentivized to keep making the interest payments "or else". Or else you lose the house and still need a place to live, or else Twitter gets foreclosed upon and the ego driven project turns into a failure.

I think it's a striking demonstration of the perils of living above your means. If we take the definition of "poor" as the inability to pay for one's monthly upkeep, it's possible for Musk to simultaneously be the richest and the poorest person in the world.

And sure, he could always increase his investment by using more personal funds to make the interest payments, taking the longer term view (whether business or idealistic based). But the fact is that he hasn't, and has been framing this situation exactly as Twitter needing to immediately service that debt.