skysight-inc/HackerNews huggingface dataset:
Probably because the food isn't good and they're paying for it?
The active form of B6 is the enzyme cofactor used by AADC:

https://en.wikipedia.org/wiki/Aromatic_L-amino_acid_decarbox...

AADC is an enzyme in the path that converts amino acids into dopamine and PEA/NMPEA (see "biosynthetic pathways" in above link), the latter of which is an endogenous structural isomer of amphetamine.

You're not really making a strong case that this isn't about dopamine or that amphetamine is the wrong thing for it.

Moreover, B6 will make more of these things up until the point that it's no longer the rate limiter in their production, if it ever was. (The rate limiting step for dopamine is ordinarily AAAH converting Tyrosine into L-DOPA). And if you hit a different rate limiter before you have enough dopamine or PEA/NMPEA, what then?

Important note: This is also a thing:

https://en.wikipedia.org/wiki/Megavitamin-B6_syndrome

> Megavitamin-B6 syndrome has been reported in doses as low as 24 mg/day.

Meanwhile people sell 500mg B6 tablets and it has a half life of like a month. Ask your doctor etc etc.
God bless the internet!
I have a very limited experience with Python (3 months of production experience), but vast Ruby experience and I think a lot of the things apply to both. For me these are reasons why I would choose Rust over Python or Ruby in most cases:

* it's relatively easy to write code that will pretty much never crash. yes, Rust will not prevent all of the bugs, but it will prevent almost all of the things that end up as a runtime exception in dynamic languages. So ou will not end up with an error tracker full of errors

* refactoring is so much easier in Rust - I can enter a new project, change a bunch of stuff and after I fix compile errors and tests my confidence that I didn't break anything is like 10 times higher than in Ruby or Python

* while most of the time speed is not a major concern for backend development, it sometimes is a huge bonus. There were cases in the past when I had to spend a lot of time to optimise Ruby code, because it was just too slow (imagine rendering a lot of HTML, doing computation that is hard to do on the DB side etc)

* handling JSON with serde is just on another level

* Rust is very versatile. When a company starts using a language, they will naturally try to fit as much stuff into the language as possible, after all if you have mostly Python devs, you will prefer Python. A lot of people say "just use the right tool for the job", but even if there was something like "the right tool for the job", in practice it's more like: if the downsides of using our primary tech are huge, let's consider introducing a new language, otherwise let's stick with what we have. I've seen it numerous times in the past. I feel like with Rust the downsides of using it for most of the stuff are much smaller than for example for most of the other languages
I totally agree... crazy times in the past few years. I have heard that some people were able to borrow against their "wealth" (stock holdings, crypto holdings, vested ownership shares) for homes, cars, boats and more since Covid. If their "wealth" suddenly evaporates in the form of losses, they find themselves on the wrong side of the trade. Super duper risky and the appetite for these "products" was immense from what I understand.
Yawn, more of this silly apple snobbery. Yes, honey crisp is a good apple, but red delicious is also fine. The difference in taste between table/dessert apples is mostly personal preference. Get over yourselves, you are not better than the many people who prefer red delicious, and your palette is not more refined. I've met apple farmers who rather like red delicious, surely it's not because the poor wretches just don't have access to the other kinds, or know nothing about apples.
Looking like I am wrong on this one, as the media coverage grows.
> I don't care what the hell he did, this kind of abuse is not acceptable. It's no wonder Americans have lost respect for law enforcement: the people enforcing the law are often committing worse crimes than the supposed criminals.

You are going to be very upset when you find out what police have done to citizens while they were sleeping in their homes. [1]

[1] https://www.nytimes.com/article/breonna-taylor-police.html
Somehow this triggers memories of (among all things) taking exams when I was a student.

Unless you prepared well, there's often some exam questions you are clueless about, and yet there's usually no penalty for writing some bullshit in the hopes of accidentally getting a partial score. So what students are trained to do is to write whatever bullshit that seems to be relevant and hope for the best.

I realized the mindset that makes me a quality-conscious programmer is actually the anti-thesis of this. In fact during my later years I almost couldn't do that exam-bullshitting any more. It feels so bad writing something I don't understand that I almost couldn't do it.

This might be offtopic, but I guess many people who don't have a natural OCD-tendency to deeply understand their work and care about tidiness might have to actively unlearn what they trained for at least a decade in school...
What most (management) people don't get: The IP are the people, not the code.
Nobody wants to read and understand a large code base and there are mostly no secret, revolutionary algorithms in it. However, the developers that wrote that stuff can easily rebuild everything and most probably a better, improved version of it.

Companies: Protect your developers, not your code!
As a bot dev, this looks very interesting but quite underpowered. Maybe I just hang around in gaming communities where custom bots are common for non-trivial tasks like querying game APIs, organising parties for different activities, etc where I don't really see this being useful.

The cases that it does support, however, are quite helpful, and is currently only done by cobbling together a bunch of bots, as you said. Good job on launching :)
I don't think the OP disagrees that a psychiatric condition is a real condition.

I think they're just asserting that they should be properly assessed for that psychiatric condition before euthanasia. That goes for any condition: they want to have at least tried courses of treatment that might fix the problem.

This is complicated by the fact that some psychiatric conditions make themselves difficult to treat. They compel the patient to avoid treatment. This is a thorny ethical issue under ordinary circumstances, and even more so when the outcome is terminal.

If the patient believes that their condition is debilitating enough to merit ending their life, it is a matter of law that they should at least have to have a doctor's affirmation that it it has not responded to the standard of care. That means treating a psychiatric condition on a par with physiological ones.
These people are spies. What did they expect?

Throw them in ADX like the rest.
I can only hope crypto dies soon.

Its actively a violation of the GDPR and this illegal in the EU.

It violates human rights laws, including privacy laws, and is this illegal in most other places.

It violates all the laws around SWIFT, at the international level, so its illegal under these laws.

It never should have existed. Its a grift and a scam; Even NFT's vanish when the host doesn't want the expense of hosting other peoples images.
At marathons they have those solar blankets. Law enforcement could easily provide clothing or blankets for those being raided. Everyone deserves dignity imo, even potentially guilty people. No risk involved.
You could ask the local DPA to look at your former employer(and then sue them if they decide to ignore you). Companies have been fined for lax handling of employee data.

Slack is likely trying to operate under one of the attempts to replace the invalidated "privacy shield" framework(the current attempt is summarized here https://www.tadpf.eu/) for their European enterprise customers, and a part of this is having contracts prohibiting slack from handing out the data to any 3rd party, but your relationship here is with your former employer and not slack.

the Schrems rulings is a bit of a problem for slack here but that's not because slack is necessarily violating the GDPR directly but because the US does not live up to EU's standards for what a modern democracy is allowed to subject people to to in terms of protection against "unreasonable search and seizure"(this term actually comes form the Fourth Amendment of the us constitution but somehow the US courts don't think it applies to foreign persons or digital records held by cloud companies).
I read that book and came away feeling underwhelmed. She went into many patient interviews with her model in mind; did she instigate patient behavior through questions? The book was often vague when it came to her interview methodology, and favored development of patient story, IMO to latch onto reader’s sympathy, while offering little detail of the authors methods.

From the authors reference frame the patients appeared to linearly accept their fate. If we randomly time traveled to their room and interviewed them which state would we encounter? Is the progress static regardless of environmental inputs or variable?

I have a hard time trusting past truth these days; editors and publishers want to sell books. There’s a huge labor market dedicated to PR and optics, tailored messaging. Sensibilities of the past were much more accepting that whatever made it on store shelves was absolutely correct and not a tailored product placement.
>For the greater world I'd say definitely.

Could you elaborate? I honestly don't understand...

The effects of subprime crisis was not limited to the US. And instead of people not being able to afford homes, there were lots of people worldwide who lost their homes after they lost their jobs and their properly values collapsed.

https://www.globalpropertyguide.com/investment-analysis/The-...

Opendoor is US only (as far as I know) so the layoff justification just seems silly.
Stop it! I have a lot of real work to do, but my urge to binge "J for C Programmers" is getting harder and harder to control :)
Here are a few simple field tests you can perform to measure maximum running heart rate.

https://marathonhandbook.com/how-to-calculate-max-heart-rate...

Note that wearable fitness trackers that use wrist optical heart rate sensors often don't give accurate readings on such tests so it's best to add a chest heart rate sensor.
I'd say the difference with the stock market is that that the bottom of it is composed of companies that produce and sell actual, tangible products: cars, planes, oil, computer software, construction materials, etc. All financial instruments (legitimate or not) are built on top of this. You buy into some index fund under the assumption that, on some level, you're putting money into the production of goods and services.

Meanwhile, the "crypto market" deals only in hype all the way down. There are no goods and services produced (unless you count "hype"), only dollars going in one end and coming out the other. If I put my dollars in some "crypto investment", it's only so that some early adopter with 50000 btc can get some dollars out. The rest is misdirection.
Not thrilled at how hidden the business model is. There's no paid option, just targeted ads (as noted in the privacy policy about how your information is used).

Unfortunately, this means that it's not for me. For whatever that's worth. :)
My two ADHD comments gave me -9 points. Lol.

Yes. It’s my opinion. I wish I had a Scientific prove on it. But logically. It makes sense.
Capitalism is at fault here.

Unless there are right regulations in a capitalistic system, capitalism will create abuse and problems.

We are in 2022 and it's really annoying how we cannot discuss deep changes in how capitalism functions unless an army of trolls brings up the gulag point: "the soviet union failed, thus there is no viable alternative to capitalism".

It's already almost difficult to discuss it criticize growth, so socialism is really beyond taboo.
R has `rep` for replicate:

rep(c("a", "b", "c", "d"), c(2, 1, 0, 2))
c("a", "a", "b", "d", "d")
If you didn't count the "theoretical" wealth you wouldn't call them billionaires in the first place.

That "theoretical" wealth clearly has a massive impact on the real world, so it's silly to pretend it does not exist. For example, Elon didn't buy Twitter with a giant bag of gold coins -- he borrowed against his wealth, which is mostly in stock.
Forth, Lua (with LuaJIT pretty quick), Scheme, Pascal, probably a lot more.
Many people have a net worth greater than the number of circulating dollars. Also, dollars are not risk-free. They target a few percent annual loss, after all!
App Tracking Protection Open Beta in DuckDuckGo for Android
MLM and Ponzi are is still going strong, so crypto has nothing to worry about.
Consider reading the article before you spend multiple paragraphs criticizing the source, because the actual outcome was that Heather Wallace is now barred from her career field and is considered a danger to children.

Also, for all of your hand wringing over the source, you failed to realize that this is original piece by Lenore Skenazy, probably the most well known advocate for the free range kids movement, and she has not only contributed to Reason, but also the NY Times, WaPo, the WSJ, NPR, and PBS, among others.

Blindly criticizing a source without either reading the damn article or caring about whether the piece was from an original source is incredibly intellectually lazy.
[Sort of off topic] While I don't like that Tiktok has close ties to the CCP and I can see the see the potential security threat it poses with manipulated social media trends and spying on it's users. I'm starting to second guess the idea of banning it. At least without a viable replacement.

My stance is this, most of the big names coming out for a ban are either conservative leaning institutions or just plain conservative. FBI and Marco Rubio. (I'm old enough to remember a rogue FBI branch pressuring the FBI director to release a scathing report on Hilary Clinton just before the election)

I think TikTok is filling a void for Democrat messaging that Republicans/Conservatives have ie: Fox, conservative youtubers, breitbart, etc. The left is doesn't have this and TikTok has been useful for sharing concise information in a repetitive and engaging fashion. I have a hunch it's a large reason why we had such big youth turnout this midterm election cycle.

TL;DR: Ban TikTok when there's a good home grown replacement. Or Nationalize it's US/Western wing and spin it off as a separate entity
> I am currently in the mindset that I don't get to choose what I do. I either do it, or I don't and that has forced me down a route to where I find myself. Which has really worked out. But only because I caught myself and that those knife edge moments went the right way.

The problem that I found as I got older is there's substantially less room for just going with the flow. It worked great for years. Now I have people that I'm responsible to and do it or don't do it doesn't work. I can't just leave it to chance if I sit down and read with my kids daily or cook them healthy foods. Their lives will pass by while I'm wondering around waiting for the inspiration to be a good parent.

So a heads up, that works great when no one depends on you much. It works a lot less great when you owe people things that you really care about.
Now I'm curious. What is your definition of a journalist?
One lesson I’ve learned from this case and Theranos — avoid anything that comes out of Stanford.
I've been down the road a bit and I appreciate that code wont take up any space and wont collect dust, but I also appreciate people willing to take care of that and really preserve the hardware, so more power to you.
C++ does not run as well on the browser.

Yes, QT on the desktop is very good. There are bindings for Rust too, as there are for most languages, but the most integrated one is C++. (I'd say the close integration is just not worth it.)

Anyway, I don't know why people want so badly a single language to run on every context. They are forfeiting a lot of value for that.
"Bankman-Fried told Piper that he's still seeking to raise $8 billion from outside investors, in order to make customers whole, adding that 'a month ago I was one of the world’s greatest fundraisers.'"

Part of me thinks that maybe SBF actually is as bewildered as he sounds, about why it all came apart. Whereas Bernie Madoff knew he was presiding over a Ponzi scheme and was only surprised that it lasted as long as it did, SBF might have actually believed that he was as great at business as his media puff pieces said.

Like a person pre-2008 who believes they can afford this mortgage because the bankers are willing to lend them the money, and why would they do that if I couldn't afford it, SBF may have believed he must be great at business, because Sequoia and SoftBank and the rest were loaning him money in huge amounts, and they all had lots of experience in the space.

None of which means he wasn't guilty of fraud, but he may actually be a bit of a tragic figure, in some ways.
Two questions: (1) there are torrent backups of LibGen, right?

(2) If (1) is true, then I can download a book with a magnet link, and they'd have to arrest hundreds or thousands of people all over the world to prevent it.

The UI for for finding and downloading a single file from a massive torrent is not very good in any torrent client I've used, but how hard of a problem is that really? Is there not tremendous value in solving it?
I understand, but part of the draw of Raspberry Pis is the price. When that price goes up by 20x, I can't imagine very many scenarios where that would still be worth it, regardless of the size of the community.
>them purchasing the naming rights to Miami's stadium and all the A list celebrities prompting it just added this fake layer of trust.

This never made sense to me. To me celebrity endorsements and purchasing naming rights only mean that you have the money to pay for them. It might convey some legitimacy in the way of "they can pay for it", but I don't think of them as some sort of stamp of approval.
When I was young I too had encounters with them and it was less than ideal. But I also feel that without them there society would be worse off. Yes, there can be improvement and they definitely need to better weed out bad apples (they need to better detect criminals within their ranks --just like the clergy needs to and schools need to). But also realize they are doing what society is asking them to do. Allowing some discretion is what allows them to ignore homeless in the park or in a ditch or wherever the locality finds unofficially permissible. If they followed the letter of the law in many places, they'd have to call in the paddy wagon way more often.
You can prove you actually own how much you want to prove you actually own, without leaking any other information on your identity or current wealth. You can sign documents. You can mount complex escrow processes with it. You can send it worldwide to anybody without even knowing where they live (phone numbers fail), or what their bank is (IBANs fail) or what their email is (gift cards fail) or whether they are allowed by someone else to receive money (paypal fails). You can pool it with friends and set up conditions for safe withdrawal reliant on multiple people agreeing at the same time. And you can receive money from anyone, anywhere around the world, without anyone else's permission.
BQN is great, but I rarely get to use it for anything... useful. I hope the ecosystem and tooling around bqn will get better in the future. I would like to see something like what dyalog is to apl for bqn. A jupyter notebook style ide+repl (maybe a bqn for of RIDE), libraries for common scripting tasks, embedding (a la lua) in more languages, maybe even a way to compile to libs so you can call bqn code from other languages. I'd definitely use it more if it was open to more use cases.
You can easily test relatively accurate max heart rate just by running a 5K race. Run a slightly slower than race pace, and go as hard as you can at the very end (last 1K) with the goal of sprinting to the finish line and vomit. It's unpleasant, but relatively safe during a race event with medical staff there at the end.

Also, max heart rate is only useful after you've been running for awhile. If your body hasn't started adapting to the change, MHR doesn't do much and often inaccurate. It's like 1RM in lifting, 1RM is meaningless in beginners as their bodies and central nervous systems haven't learned to fire all the muscles yet.
"empirical evidence" would likely require a breach of research ethics, but I suppose you could randomly borrow your neighbors cats to observe owner behaviors.

Just kidding, as being a "jerk" with facts is not a character flaw from my perspective. lol =)
The government doesn't need a cryptocoin to monitor transactions, or to make using paper currency illegal. It can already do what you think it needs a cryptocoin to do, and it doesn't do it because it supports wealthy people being able to launder money and avoid taxes. US politics runs entirely on laundered money and misdirected/avoided taxes. You're lobbying for the swamp.
Devenv.sh: 0.3
>> smart contracts didn't exist when they first started.

> Calm down. That is not true.

It pretty much is. Bitcoin's solution to scripting exploits was to weaken scripting. It would have been impractical to use BTC for defi and more work was undergoing to fix those problems. The weasels snuck in at the beginning and now that we can do without them they're already in the walls.

> Smart contract based exchanges do not let people exchange real money into crypto.

For trading there are a couple of options (aside from Tether, which is a scam) for pegging a trade to USD.

For on/offramp, you are sorta right. If I want to trade for strawberries I need someone holding strawberries, and I have a risk he'll give me raspberries.

> Centralized exchanges will always exist because people want on / off ramps, people want low fees

On/off ramps don't require centralization, they only require one legally bound actor, and we can all pick our fave. You may trust a lawyer near you, I may trust my local gold bullion store for up to $5k at a time, etc.

Low fees are far better achieved by a channel or rollup based solution, where the assets are essentially on-chain the entire time.

> and because people are willing to trust others.

This is bad argument. You're trying to make trust virtuous even though removing the need for trust is far better for society - removing risk and friction for everyone.
You do realise this is nothing new and you can use TransferWise, MPesa or PayTM for this right?

Bitcoin is slower than all this and violently fluctuates which loses people's money quickly. People also need to pay their bills in fiat anyway so whoever is receiving the Bitcoin needs to cash out to fiat anyway.

At that point you might as well just use fiat instead.
Well, the image doesn't contain that much more content
Well said, this is clearly the case here.
why pile more suffering on top of their current amount?