skysight-inc/HackerNews huggingface dataset:
Yes, CAR-Ts are really a B cell receptor (otherwise known as an antibody) grafted onto a T cell. Antibody directly binds things like proteins, and usually targeted to things found on cell membranes.

Also on the cell membrane is MHC-1, which shows a short (9-11 amino acid) fragment of protein produced from inside the cell. Our T cells are trained in our T cell kindergarten (the thymus) to not identify our usual self proteins, but detects anything different. They have already been demonstrated to identify single amino acid changes from normal.

Yes, the micro-environment means the immune cells reach a dynamic equibrium. This is because when a cancer presents to healthcare, it is already a chronic process. The T cells are termed 'exhausted', but it's debatable whether this is a good term for it, because they are still active.

A lot of cancer treatment 'shakes up' the microenvironment. This can be enough to tip into a cure. When you make CAR-Ts and adoptive TILS you either pick healthy T cells not involved in the cancer or buff them up in the lab, both in numbers and health.

The hope is that a refreshed army of T cells will push that dynamic equilibrium towards a cure.
No, the sharing aspect is internal to the app, so each "board" can have as many users as you like.
Neat idea though, I'll have to look into that.
Random Number Generator in Google
I think the jury is out on YouTube being social media. Like yourself I'd agree it's not social media based on the way I use it.

For people who just watch the videos it's purely a video streaming site. For other users it's social media because they use comments/messages (if it has this feature).

It ponders the question that if a website can be used in 2 ways (as a social network, or as an information/entertainment source, like when lurking anonymously), whether you should really call it by it's full-feature name.

For the most part, I rarely write on HN and I browse Reddit but don't have an account, so am I using them as social networks?

And if on a site like HN I can't add somebody as a friend, and always reply once or twice to a fresh user I've never met before, does that still count? Is it socialising or just taking part in a one-off conversation?
Most people in the world pretty much have to, due to the prevalence of English in CS based businesses, projects, and academia.
They conluded, based on teleme^wanalytics, that after you've seen the beginning, you want to see the end. /s
Difference between Musk and Zuckerberg's handling of layoffs is striking.
I don't think it's good on paper any more. Change control should happen in source control with lots of automation keyed off it. Meetings should be designed around that primary principle.
The idea that our society is purely a meritocracy is a myth that does not hold up to thw most rudamentary economic analysis.
The “What are monads” fallacy
In Germany, public officials ("Beamte") are paid a bonus depending on (a) their marital status, (b) the number of kids they have and (c) whether their spouse is also a public official (you get less then to avoid receiving the children bonus 2 times).

This has multiple reason: one feels a bit ancient as the states basically want their "Beamte" to live in an "orderly" family situation and thus encourage marriage and children.

However, AFAIK, a major reason is to counter a disadvantage "Beamte" have regarding health care insurance. For historical reasons, they are not part of the public welfare system (or rather, they are in a different, older one). The state pays half of their medical expenses (if you are part of the public health care system as a "normal" employee, your employer pays half of the health care insurance). To cover the remaining 50%, Beamte need a private health care insurance. In the public health care system, your children and non-working spouse can be added to your health care insurance for free. With a private insurance, that is not possible - you have to pay for an additional insurance for each kid, and your spouse if he/she is not working.

There is a calculator for the federal level here: https://oeffentlicher-dienst.info/c/t/rechner/beamte/bund?id...
It seems like you didn't read the article thoroughly. Why the cheapshot remark?
Could creditors make a case those were stolen funds and try to claw some back?
FTX Crypto Exchange Boss Says He Is Trying to Raise More Money
> Enough people think Gough was bonkers

There is much discussion about how in the cold war, a swath of countries from East Germany to China ran as states led by one party. Not much discussed is how many western aligned countries did as well. As the Cold War heated up, from 1949 to 1972, the Liberal coalition ran Australia. In 1972 another party is elected into power, and an extraordinary amount of energy from within Australia and without (UK and US) went into undermining anything but the old one party led coalition. Whitlam was undermined every day for his less than three years in power, then ousted by the retainer of a foreign queen, so that the one party led rule would continue to 1983. Of course the undermined <3 year interruption to one party led rule was "bonkers" to those supporting decades of one party led rule.

One party led rule from 1949 to 1983, with the one elected other party with less than 3 years ousted by a representative of a queen. These people then had the gall to criticize the one party led coalitions running China and East Germany as being one party states that blocked political pluralism.

The same thing happened in the other western aligned countries in the Pacific during the Cold War - Japan, South Korea. The same case in South Africa, Italy, France etc.
What are i(f)tables? Google does not suggest anything.
Does Google guarantee that they don't collect the data anyway? I always understood that as "don't show me my history" rather than "don't collect my history".

Fancy downloading your YouTube data checkout to verify?
Id expect its something that customers have asked for and theres ~0 marginal cost to provide it. I can see two aspects for customers; its simplicity & consistency with edge or on prem nodes using the same time source as your cloud infra. Theres a degree of trust and consistency for those same customers to get time from AWS instead of a random pool.ntp provider.

Disclaimer: principal at AWS but the above are my sole conjecture/thoughts. I have no involvement or inside knowledge of this service release.
those are normal flip phones, not what the parent is referring to:

>two square touchscreens and attach them with a hinge, like a pocketwatch
The OP link is...not great.

It's a reddit post[OP], that links to an article[1], that links to a specific comment in a reddit post[2] which is a reply to the actual comment[3] that contains the link[4] to a specific section of a YouTube video, which contains the actual confirmation.

After sifting through all that, they didn't give a reason, which is pretty lame, but alludes to the fact that it's helpful for them and not for you. Presumably this is step one in storing old videos on glacier-like storage so it costs them less (and inevitably will let them play you more ads while they retrieve it)

[1] https://piunikaweb.com/2022/11/10/youtube-sorting-option-for...

[2] https://www.reddit.com/r/youtube/comments/tx0uln/question_ha...

[3] https://www.reddit.com/r/youtube/comments/tx0uln/question_ha...

[4] https://www.youtube.com/watch?v=I0WYt7hgXhQ&t=48s
Jenny Hocking is considered by 'serious' historians as a hack. Her biography of Murphy borders on hagiography. The Palace Papers were a dud that she is still attempting to show point to QEII/Buckingham influence in the dismissal. Barwick, who was the chief justice of the high court at the time, said that the constitutional crisis was Whitlam refusing to resign upon failure to secure supply. Kerr dismissing Whitlam was resolving the crisis.

In the end it is academic. The Australian people had their chance to judge the performance of the Whitlam government at the election held 13 December (both Whitlam and Kerr knew that 11 November was effectively the last day that this could be considered due to the requirements for elections to be held) and delivered a resounding message to the former Whitlam government. Even if Whitlam had the half senate election he wanted, it would not have achieved his aims and he would have had to take the issue to a full House election.
> Your multi-year investment can be taken away at any time on a whim at your supervisor's discretion.

I disagree:

I often say that the true value of the PhD/doctoral studies is that you have the opportunity to work on deep questions/problems on the boundary of human knowledge that you won't find anywhere else. The PhD or doctoral degree is just an icing on the cake that you will get at the end.

If you do your PhD/doctoral studies for the degree on your business care, you will, in my opinion, not be happy. Better look for a career elsewhere since if you are not insanely passionate about the scientific topics that you work on, PhD/doctoral studies will become a nightmare for you.

Before starting a PhD/doctoral program, you should ask yourself: is there anything that you would desire more than working 14 hours a day, 7 days a week on your research topic? If the answer is yes, you have, in my opinion, either not the character traits necessary for science or at least a topic of research that is a bad fit for you.
> But I am aware of a 51/49 class split between Liberal and Labor over Gough ..

This may be a somewhat outdated appraisal of the situation.

The number of people voting for neither of those parties (including coalition members) has been steadily growing for years, with the most recent federal election reaching 33%. I recall, more hazily, that the previous federal election (so several prime ministers ago) it was just north of 25%, which even then put us ahead of a lot of ersatz democracies where only two realistic options are presented to the population to pick from.

The idea of being 'glued' to a political party, or a political personality, feels a bit out-dated -- and/or a bit American (no offence intended to our cousins across the pond).

I find the growing popularity of a more nuanced political landscape domestically to be hugely encouraging, but somewhat tempered by a fear this trend can (also) be manipulated, once they work out the algorithms.
Who is that a problem for? People and businesses negotiate prices all the time. No one is forcing anyone to be paid the same. If the people have an offer to get paid more elsewhere, they should change jobs.
I'm exchanging my work for money, and for equal work I'd expect equal money. I'm saying this as a parent.

Are you also willing to pay more for someone living alone and that therefore can't split the costs with a significant other?
Very interesting paper; an improvement on AlphaFold2.
>(it is impossible to convince societies to take massive quality-of-life reductions)

Why do you say degrowth = lower quality of life?

Let me give you a simple and practical example: an American living in a suburb takes her gas-guzzler 3-ton SUV to go shopping or to the park, stands in traffic in a 4-lane freeway for one hour. A Dutch living in a suburb takes her bike to go shopping or to the park, rides it through a nice street for 10 minutes. The former consumed much more resources than the latter. Who has the better quality of life?
These camera and microphone switches are available by default in current version of Android. You don't need graphene for that.
And yet I have multiple emailboxes and gaming accounts that I used for years - but can't login into now, because I forgot the password and sometimes even the username and registration email. Is that not normal?
Why is a reduction in consumption a "massive quality of life reduction"? For example reducing your working hours / increasing vacation time is a quality of life improvement, and a reduction in economic activity.
Two things are generally required for a Westminster-system government to have mandate to govern: supply and confidence.

Supply relates to the access to money, specifically through approval of the government budget. If a government has supply, it has an agreement with enough members of the house that it will retain approval to spend money on its policies. If a government loses supply, it loses the support of the house to spend any state money.

Similarly, confidence relates to support that the government represents the will of the people. Just as with supply, a government must secure a vote from enough members that they will support the government’s actions (they have confidence in the government). When they talk about a “vote of no confidence” it specifically means voting to remove support of the government in this way.

Further info can be found here: https://en.wikipedia.org/wiki/Confidence_and_supply
Absolutely. Among other things, creators remove their content when it stops being fashionable. Half of my personal video archive isn't online anymore because the creator decided it was too edgy.
Accurate time is critical for ensuring Data accuracy and most apps utilize the system time. There are also a lot of Database functions that require accurate time. If you want to do DB clustering then a good reference time is required and Oracle even went so far as to make a service called "Cluster Time Synchronization Service (CTSS)" that specifically validates the system time configuration. Although why they still only support ntp and not chrony is something I would love to know.

What is Data Accuracy, Why it Matters and How Companies Can Ensure They Have Accurate Data.[2020]
https://dataladder.com/what-is-data-accuracy/
> That said, even if economic activity was fully decoupled from emissions, Earth's environmental problems would remain overwhelming. Biodiversity loss, deforestation, aquifer depletion, desertification, etc. are just as concerning for most people here as rising global temperatures.

The issue I take with the “Global warming” crowd is that there’s a lot inaccurate predictions (nearly all of them thus far) and the evidence misrepresented and questionable.

Personally, this makes the “warming” tied to “emissions” just seem like a red herring. If I was a company producing forever chemicals, but low “carbon emissions” and I could afford the carbon tax, and extra carbon reducing infrastructure. Of course I’d promote the “green agenda”. It’s a barrier to new comers and it distracts people from the poison I’m adding to the environment.

If it becomes too burdensome the whole “carbon reduction” crowd just moves to a different country. One that slows higher level of pollutants.

These policies, to me, are really just business decisions.
We should reindex youtube and use that then :)
As slowly as possible is often a good strategy.

I used a bunch of spare cash to pay down my a lot of my mortgage a few years ago, which I now regret.
I would discourage the idea that wife beating and believing in communism are in any way similar.
The definition of free market is that information is avaliable.

I dont understand how people that declare they believe in free market, want information to be hidden and the market to be less free.

Additionally most of them are employees.

It should be obvious that freely knowing salaries will improve the employee's ability to negotiate the wage they deserve.
Setting up Postgres is a PITA compared to SQLite. It comes bundled with python these days. Obviously it's going to be a trade off as to which one causes you more pain.
yes you can. Use Kwenta, Dydx, etc. Shorting, leverage, L2 so low fees (in pennies)... all supported.
You're right, it should be compared to Mesa/Cedar,

https://www.youtube.com/watch?v=z_dt7NG38V4
> It's all fun and games

No, it's rape and sexual abuse.
Right but it's sold to employees as based on cost of living, quite a few remote companies do this for example to have flat rate salary bands but still pay less based on location. For example:

https://about.gitlab.com/handbook/total-rewards/compensation...

We could of course quibble about market rate and so on but that shouldn't be locally based in a global marketplace. The fact that a software shop down the road from me pays peanuts when I'm looking for work with companies in other countries that otherwise pay their staff very well isn't important IMO and IME.
Setting up my own Mastodon server
The mildly uncomfortable aspect of it is that <i lang="la">veni, vidi, vici</i> might change the font the text is rendered in, because the generic font families (e.g. serif, sans-serif, cursive, monospace) can vary by language. For me, for example, my usual serif is Equity A, but in Latin it changes to Noto Serif and I haven’t been bothered to patch this up in my Firefox config because it takes far too much effort, requiring changes in a number of languages (not such as French (fr), but yes such as Latin (la) and Māori (mi)). Or sans-serif: Concourse 4 becomes Noto Serif. This will honestly cause me to omit lang=la in some iffy cases where I would write lang=fr on a similar word or expression from French.
We still have an advantage on some areas, such as communication and a big part of the education. But the level of improvement in Asia is really big already.

I do not talk from outside. I have been in Asia for 11 years living.

If we do not give a push to our mindsets, we will become irrelevant and that includes leaning on effort and self-reliance and self-improvement, which is what took us here. I see (Europe, dnt know US but from the media looks like kind of the same) a huge amount of rights and whining.

I know I will get more negatives for this. I just describe what I see :)
The Problem with Functional Programming
"his management style"

Hitting a pen and implementing his cool ideas unilaterally, followed by a speed bump and new opposite cool ideas a day later?

So passe. So cool!
I believe several countries do that. For examples:

"Norway, the country where you can see everyone's tax returns" - https://www.theguardian.com/money/blog/2016/apr/11/when-it-c... .

What We Can Learn From Sweden's Public Records of Salaries" - https://theculturetrip.com/europe/sweden/articles/what-we-ca...
Can you describe how a bank uses money that it has to originate loans?

EDIT: note that this paragraph (and the one preceding it) directly contradicts what you are saying:

This description of money creation contrasts with the notion that banks can only lend out pre-existing money, outlined in the previous section. Bank deposits are simply a record of how much the bank itself owes its customers. So they are a liability of the bank, not an asset that could be lent out. A related misconception is that banks can lend out their reserves. Reserves can only be lent between banks, since consumers do not have access to reserves accounts at the Bank of England.
you ordered from a brand which is considered premium in India. You can get similar kind of glasses at even lower price at lenskart.com and from local stores.
I bought a yearly zoo membership, which is where I work most days now. I get to hang with the animals after work, and there are plenty of quiet, forgotten spaces within zoos. The zoo cafeterias/cafes are basically empty on weekdays, so I just bop around day to day.
They have both, although the single day rental usually is restricted to the open areas and conference rooms. I used it for a few days a couple months ago in DC, it was nice to get out of the Airbnb I was in. But also relatively cheap ($19 a day with no commitment), and it looks like that location has closed since :(
This seems either too much or not enough. Is it ok to pay more for risky or injurious jobs? If so, why not for medical trials?

Simply working in a job where you have to kneel or lift your arms above your head all day leads to long term injury.
It doesn't have clear semantics. <cite> is basically used as "I want something in italics, and it is the title of something" rather than "here is a reference to a creative work". And it gives the lie to semantic markup: we only ever have semantic markup for things we can reasonably expect to be visually set-off. Something like a persons name or a cut-off phrase are never marked up semantically; there could be massive benefits from semantically attributing lists of city/state combinations in flowing text but it just doesn't happen. There's nothing more than semantically attributed visual markup, rather than being semantic markup, and this kind of renaming of <i> is just going overboard.
Couldn't agree with you more but I think the sociopath in this case is product owner forced to do something when do nothing is the right answer, either that or its some dark pattern where they remove the functionality to drive everyone to use it again when they restore it.
Ironically, we're not very efficient at all with our land usage today. Nearly 60% of global agricultural land is used for beef (either for pasture or for growing feed) and yet it accounts for only 2% of our calories. And about 50% of all food is wasted – simply thrown away.
Just how complicated could it be to register a German company?
There is still time to deescalate if only sane people would we can avoid this cataclysim. Only one person near me shares this concern. We really need something like a new threads movie and fast. People are too young to remember the danger and are sleepwalking into an unwinnable conflict.
This is a reasonable attitude to take if workers are given credit and compensation based on unfair political factors, and in general, factors other than performance or special needs. It does not matter if the worker performs a task different from yours, so long as their wage is unfairly inflated so as to take away your share of the surplus of revenue.

Therefore, it seems beyond risky to say that knowledge work makes roles so vague and uncertain that people cannot know when they are being exploited. The pay gap between the C-suite and the main producers at a knowledge org is just as bad as at an org focused on physical production.

If after a moment's thought you still think that we cannot organize to reduce the pay of executive class because the executives do work different from ours, I encourage you to reflect more deeply on this. It's perfectly reasonable to demand that your bosses and seniors get paid more fairly, even though their job differs from yours.
Those are different things: working does not necessarily increase consumption. (Having more money generally does, though.)
Note that Go is not memory safe for concurrent programs. Memory safety is ensured for sequential code only.
https://www.thecut.com/article/cancel-culture-high-school-te...
After Musk, there is potential where previously, before Trump, there was none.
If this is true - whoever is making product decisions at youtube is sending it to irrelevance. Its such a wannabe tiktok clone move no differentiation.
Nonsense. This is MDN docs, not the spec. Don’t conflate or confuse them.

In this specific case, it’s probably just a bad mechanical translation, possibly from long ago as part of a batch i → em change, or possibly recent in their conversion from HTML to Markdown (might have done both em and i → *). Ill-conceived in either case, but not the end of the world.
It amazes me that climate activists never seem to push for nuclear, the most obvious solution.
> I once had employer tell me that because I was single with no kids I did not "need" as much income as a co-worker with multiple kids...

Why not rather: you don't have such a time-intense hobby such as raising kids, so you deserve more income.
>have never been able to separate their music part

They could and they should - and is simple: just remove all music from www.youtube.com. This is what they should have done when then created music.youtube.com.
SQLite has strict mode now
Is it usual where you work for everyone with the same title to make the same amount? Everywhere I have worked your cost of living adjustment each year is based on performance appraisals. So after a few years you'd expect people to make significantly different amounts.