skysight-inc/HackerNews huggingface dataset:
I totally understand the frustrations experienced by the author of this post. I am a nurse and my exposure to the Clinical Trial Industry came from a more bottoms up entry point. Its mind boggling to the the total costs CRO's charge for the services compared to the eventual experience for the staff and patients taking part in these studies.
CRO's are in dire need of disruption. I also agree about the incestuous industry hence the very slow progress being observed. It's hard to show any progress when it's the same people moving around the same companies and implementing ideas that are somewhat outdated.
Also, from a cost perspective, i think the future is also coming to a place where Clinical trials get outsourced outside the US.
Sites and PI's outside the US should be empowered to run this clinical trials as they provide a more cost effective solution with regards to operational costs and also access to an ever growing number of patients, reducing clinical trials timelines that lead to increased costs.
I understand the need for CRO's to maintain quality, and they can do this by building out the right relationships and partnerships with overseas contractors, but i believe in the long run, this is the solution.
I believe this so much that i launched my own CRO company. Infiuss Health. The goal of this company is to unlock the potential for studies to the run by CROs and smaller life science companies outside the US.
We are starting with Africa. As soon as we can unlock this population that has traditionally just been taboo to life science companies, imagine the lengths we could go with with access other geographies.
Feedback:

Idea - I think it is a good problem to solve, for us it would be Slack + OneNote + JIRA + Github mainly. How to solve that problem (should it be an extension, software, or just good human process) I am not sure. I think there is value in the process of writing stuff up manually to a common place (such as a wiki) because we all know that when you start translating the problem into words, you often realize that you don't fully understand the problem!

The landing page is a bit thin for me to go further. It has big generic promises, and then the next step is to sign up. For me that is too much friction. Before I sign up I want to know exactly what you are offering and how you are solving the problem.

What you have done here is very very common in landing pages, even big companies with massive investments do it. They promise these "emotional benefits" or "vague technical benefits" and then want you to sign up based on that.

It costs me $100 to try anything out, even if it is free. That is the cost of my time. So to get me to spend that virtual $100 I need specifics, or I need to know your brand or something so I don't need specifics because I trust the brand.

I can't think of a software example off hand though where I trust the brand that much, such is my cynicism! Maybe Apple for hardware would be an example.
I've gone from being Vocaloid indifferent to a Vocaloid hater. Being the father of a 12 year girl who is obsessed with imaginary Japanese Vocaloid artists, I'm totally over the sound of it, although I agree the histrionics produced by these things can be fairly amazing to hear from time to time.

What I did find more interesting was the AI "sung" version of Joelene that was doing the rounds a few days ago, based on the voice of Holly Herndon:

https://youtu.be/kPAEMUzDxuo

Interested to see where that goes, although I've got to admit, I'm a purist, and any type of digital vocalist is going to make me go "meh" sooner or later when compared to even a half decent human singer.
He claims to have been wiring $25m a day from a BoA branch to banks in rural Japan. Total horseshit.
Telling engineers to break the law is astounding, but it's on par for Elon Musk. It's a good way to ensure that only the sycophants and hopeless optimists will remain at the company. That works for SpaceX, useful people are still willing to stick around despite Elon Musk, who knows if it will work for Twitter.
Lucky charms are vegan
> good for some consumers (people who value convenient shopping and fast shipping) and bad for others (people who really like independent shops).

It's bad for them too once the monopoly is strong enough that Amazon can stop caring about those things.

Preventing monopolies isn't done because it satisifies some abstract sense of justice, it's done because they genuinely hurt consumers in the long term, even if the monopoly became a monopoly because they were really good for consumers to begin with.
6?! Last time I checked anything Vocaloid it was barely on 3 and most people were still using v2 vocaloids. I'm getting old :(
You confusing 4d chess with Candyland.
Alternately, disinformation often shared with that sort of phrasing will be brought up with that sort of phrasing.

People showing actual sources rarely say "the real truth" because it is implicit that no one source has all of "the real truth" _and_ the phrase is a dog whistle.
This is the kind of thing that leads to standards changing. Just because it's a standard doesn't mean it's always the right decision.
Fine, but are there any good reasons to spend resources on fonts?

Maybe if they spent less resources on achievements, fonts, etc. and more on reliability they could improve their downtime, which seems to be happening more and more often.
>If Uber somehow lost money to drive out competitors (an insane strategy)

This is quite exactly what they did.
> He's got huge debt and declining revenue - both of his own making

While I think he has done a huge amount to scare away advertisers, I expect the ad industry as a whole is going to be seeing reduced profits for the next couple of years.
See, I’ve been wondering this, so you think that he’s driving all the advertisers and employees away to start fresh, with advertisers and employees who are loyal? Do you think the subscription service will be enough to make up the lost revenue or, how do you think he’ll earn the billion in interest payments he needs, sell Tesla stock?
l had to Iook very carefully to make sure you hadn't substituted the two Ietters. :)
Bernie Madoff was also a big political donor, didn't help him in the end. SBF will also probably not hand out donations in the near future, so there is very little incentive to help him out at this point.
At least they both don't look like the 1.

Someone's gonna lose a LOT of crypto over this.
The primary goal and appeal of Markdown is that it is easy to write. Optimizing for parsing is creating a fundamentally different product.

Standardization of the spec is good. Requiring quirky behavior and blank lines that hurt reading is bad.
> most people would succeed if put into that position (from birth, which is why this is near-impossible to prove).

It's actually very easy to disprove. There are 22 million millionaires in the US. There are 720 billionaires. That gives you a 0.003% chance of going from millionaire tier to billionaire.
It's been barely a week he's at the helm and you came to that conclusion? I'm indifferent about Musk, but that's absurd.
Not to detract from the article, but we should be using nftables in 2022. :-)

https://wiki.nftables.org/wiki-nftables/index.php/Moving_fro...
> I believed the OP was reacting to the "it's Musk's money he can treat his employees as he likes" — by way of an analogy that you thought too extreme.

That is exactly the problem. The analogy was that Musk akin to a plantation owner, and his prerogative vis-à-vis twitter employees (by virtue of being CEO, a position he gained through a takeover with his "money") is akin to the rights plantation owners practiced vis-à-vis slaves on the plantation. This is exactly what the person I replied to implied.

The problem I had was never with whether a CEO has a right to set policies like banning employees from remote work. The problem is that the analogy directly compared employees to slaves. The former have the right to walk away, the latter never did (without risking death). No matter what the antecedent is (CEOs vs. plantation owners) the subsequent is a false likeness (slave vs. employee).

And I agree that using the "n-word" would have probably been flagged immediately. And if it wasn't, it would be the focus of the comment and not the content. My argument is that functionally this is a distinction without a difference. Saying "Negros" may have insulated the poster from the immediate flagging, the thesis of their argument was equally as flawed independent of the words used. Elon Musk is not a slave-owner[1], Twitter employees are not slaves. No amount of hedging could make that analogy accurate.

[1]
Whether the Musk family benefited from de facto slavery within the emerald mining business is a different argument. One that should be discussed, but in the context of exploitation of labor in third-world countries. Furthermore, as others have pointed out in this thread, the treatment of workers in China building Tesla models could be more justifiably argued to be a form of modern-day slavery, as the worker has far less agency to actually quit and still survive. Neither of these points were mentioned in this specific thread, and neither would have much bearing on whether Twitter employees are akin to slaves.
I am a lawyer...

Constructive dismissal as a legal concept is relevant for purposes of determining whether the employee voluntary separated (i.e., quit) or was terminated by the company. This then determines the legal rights/obligations of the parties, including for example eligibility for unemployment, severance, etc.

Constructive dismissal is treated as a termination, meaning involuntary on the employee's behalf. Whether the constructive dismissal is legal depends on whether a termination in the same circumstances would be legal. Terminations are generally legal, so constructive dismissals are generally legal...

I agree that in this case the Twitter WFO policy is constructive dismissal. And elsewhere I have said this would fall under the WARN Act because it's clearly part of the mass terminations already announced early this week.
>Every place I see that offers interest on crypto deposits, I fear they have no business plan to generate the profits to pay the interest on a deflationary fake internet money in the first place.

You are correct. Literally every place offering high interest rates on crypto deposits is a Ponzi scheme.
Standard Oil was vertically integrating around oil -- what is Amazon vertically integrating?
Or install GrapheneOS? Pixel 3a support is being phased out slowly but surely but currently it's still getting all security patches.

EDIT: I stand corrected, they stopped support in September. :(
Aviation Week's Check 6 podcast has an outlook on Boeing's CEO as a money generator to reach $10B cuts to investors before a decision to design more new aircraft for the future
To save money on licensing existing fonts. Own the font, do what you want with it, independent of whatever license changes a third-party might impose years down the line.
Does money/time spent by designers/front end take away from that towards back end?
The Design of the T16 Potentiometer for the Syncbot Sex Toy
I don't know about this specifically, but my guess is that when loans are cheap it is much easier to perform a leveraged buyout: taking out a loan on the assets of the company being acquired.
Vim is definitely a brand though. It is more than that, it has cult following.

Big companies known for abandoning projects have a bad brand in that regard (although their brand might be good in other areas).
Playwright supports webkit by default, even in your linux CI.

Playwright is faster.

It's fully free and OS.

It's written by Microsoft to test their own thousands of services not to sell you anything like Cypress.

The authors of Playwright are the leads from Puppeteeer, Lighthouse, the first node debugger and Chrome Dev Tools, the engineering team has simply no comparisons in the browser automation field.
Where is there pricing?
Making safe and effective medicines is a lot harder than modern chip production because the subject is humans and we have to do medicine ethically.

The pharmaceutical industry predates chiptech by quite some time, represents a fairly large market, the companies are quite technological, but the underlying problems are very different from making chips. And if trials like this succeed, that area of biotech will see billions in funding.

It's not funded as much as chips but it's also a smaller overall market.
+1 for 100 gecs; their sound is a very distinct aural palate cleanser that I consistently enjoy. See also Charli XCX's How I'm Feeling Now album and midwxst's SUMMER03 EP
Not all infinites are the same size, but that’s irrelevant as there are only a finite number of perceivably distinct logos.

Anyway, for any distinct set of black logos you can map them to a larger set of blue gradient labels therefore the number of distinct blue logos with gradients is larger.
Tell HN: On macOS, `man-preview` opens man pages in Preview
Basically the title. I'm ok with man pages; can navigate using typical Vim keybindings. But sometimes it's nice to see them as a PDF where you can quickly find the information you're looking for.

I thought maybe others will find it useful too.
There's an issue with the editable / interactive section on Firefox, might be what you're seeing. Otherwise mono is slightly rounder than hubot (look at the "t")
Couple good quotes:

“The 4th generation Epyc Genoa launch marks the 3rd consecutive generation where AMD beats Intel in the majority performance metrics. “

“SemiAnalysis believes the gap between Genoa and Sapphire Rapids is larger than the gap between Milan and Ice Lake.”
> That activity can just be moved to another chain and avoid the audits.

> Remember Mt Gox? [...] It's viewed as a feature that everyone just loses their money sometimes [...] From speaking to them, they view any kind of fraud prevention as an affront to their definition of "economic freedom"

I found these observations to be helpful reminders how things are (and used to be!). A blockchain isn't designed to indemnify you if you hop on/off the blockchain.
Wait, I thought Chris Rock was a white supremacist........
"constructive dismissal" is an action an employer takes which the employee can treat as equivalent to being laid off. Being laid off comes with various benefits, like eligibility for unemployment, and is included in specific laws, like IIRC in California there has to be a notice period before laying off X people in the same month. "Constructive dismissal" just means cutting everybody's salary in half, reducing hours, etc counts as you being laid off if you choose to leave at that time, rather than you resigning. Resigning does not come with unemployment or those other protections.
Ledger, the leader in crypto hardware manufacturer, has a "Plausible Deniability" feature that works a bit like this https://www.ledger.com/ledger-101-part-4-advanced-security-p...
Any reccs for moving into the IaC space?
One of Twitter's lawyers literally stated in a company-wide communication this morning that Twitter employees have the right to work from home, regardless of what Elon said in his email.

Elon announced the policy with the intent to be able to fire employees who refused to come in to the office. However, because WFH is part of employee contracts, enforcing a WFO policy would constitute a constructive dismissal if actually enforced by Twitter. Meaning, not for cause, severance likely required under WARN Act, etc.
This was a great window back in time. It really conveys how what apple accomplished was the product of many hard working, passionate people self-organizing as needed to make things happen. It's sad that so much of the popular history of apple seems to focus on steve jobs as this mythical singular figure who is clearly given more credit than he is owed at the expense of real stories like this, which are much more compelling.
Is the end state of this to eventually modify people's bone marrow to produce modified T cells, or do they envision treating people with infusions of modified T cells? On one hand, permanently modifying people's immune systems seams fraught with challenges. On the other, a steady supply of cancer killing T cells sounds like a strong protection against recurrence.
When you arrive at the point that you need to draw parallels between Putin and Musk, you seriously need to stop watching the news.
Most countries have their own security laws and enforcement departments, which are nominally there to protect the interests of their citizens. Examples: https://sfo.govt.nz/ https://en.m.wikipedia.org/wiki/Financial_Conduct_Authority https://www.afp.gov.au/what-we-do/crime-types/fraud/fraud-an... However the enforcement departments usually appear to me to be underfunded and quite weak, even against fraud within their own country, and it seems rare they indict overseas parties even when citizens are deeply impacted.

The SEC is unusually strong (which might surprise you), and because the American market is so wealthy and the rules are relatively clear, the SEC has a huge influence over investment structure.
For SARS1 they detected the virus from in Himalayan palm civets at a market in Guangdong. "All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates." - which means the virus was not from human to civet as opposed to human -> civet

https://www.science.org/doi/10.1126/science.1087139

For MERS(outbreak 2012) they linked the intermediate species to be camels https://www.science.org/content/article/new-middle-eastern-v...

One thing you'll notice when reading the studies of these two viruses they both had multiple spill overs since the virus was circulating in an intermediate species.

When you hear "It took years to find the source", what they are talking about is the original bat source that the virus originated before it infected the intermediate hosts. These statements are disinformation since when people are talking about "finding the intermediate host" they are speaking of the animal the that triggered the spillover to humans which is much easier to trace and can be found quite quickly.
I've read his leaked messages. He is stupid.
While I believe you are mostly correct, a technology that allows for competition is better than one that does not (eg TWTR,FB)

Edit added: email is an example. Pain in the butt to not be on MSFT, GOOG, etc but at least it’s possible.
This is true. The answer is actually that he's a liar / marketer.

Colonise Mars? It's never going to happen. But you'll win defence and commercial contracts on the way as a side effect.

Saving the future with electric cars? It's never going to happen. But you'll sell a lot of luxury cars as a side effect.

Saving free speech with Twitter? It's never going to happen. But you'll pacify the SEC dogs snarling at your door after you fucked up.

His pitch is changing the world. His reality is not really improving it measurably.
More or less similar to my view of where he is, although I think I'm a bit less charitably inclined.

Given his priors and the fact that he doesn't understand social media, free speech, moderation or advertising, the only question is if he can control his ego long enough to find someone to run the place before he burns it to the ground, and whether anyone who could save it would trust him enough to take the gig.

I rather doubt that will happen, but maybe. Assuming he hasn't already done too much damage - I'm not sure where that line is, but it seems like we're approaching it rapidly.
You do so you can go sleep knowing you are making money and nothing breaks.

There are no tests as valuable as E2E tests.
There are already clickworker farms that will solve CAPTCHAs as a service. A CAPTCHA once per day would cost next to nothing for a bot farm.
I guess my point is browser all do easily provide (some with extensions) exactly this already - a mode where it's just HTML with some standard readable CSS already.

You can also do default user stylesheets.

This is a positive point for things being pretty well set up today.
Poor DuckDuckGo doesn't even have it on page 1.
I don't know about that. Google has a bunch of services that I can access through the "gmail" account I signed up for in 2003. But I don't use almost any of them. If they added a mastodon to that, I would hardly notice.
Fair points. I agree that having to memorize which types are arbitrarily treated as pointers in Python is a huge pain. Python also adds pain with the "default argument" issue.
Bankruptcy is certainly a possibility, but I don't see how that at all leads to the company not existing a few months from now.
After watching the video, I feel amazed by the clarity of the explanation and the examples. I didn't know what prolog is (still don't really know), but at least this video made me think about pattern matching and backtracking in an interesting way.
Skin friction drag is a drop in the bucket compared to parasitic and lift induced.

I’m willing to accept that a gold bullion transporter can look closer to a flying wing, but with any reasonable cargo density you are back to the standard design.

Trying to intuitively explain CFD results is apparently just as hard as dispelling the Bernoulli nonsense about airfoils.

I’m right and high aspect ratio wings are a harder materials science and design challenge than blended wings. There is a reason 10000x as much engineering effort is going into folding carbon fiber wings for passengers/cargo. The folding is to increase fuel economy through aspect ratio and fit in terminal box.

Everything I have said is trivial to prove with CFD and experimentally. I get that popular science articles need to entertain the masses.

Let me ask you this, why is the tail of passenger aircraft upward sloping?
> a wide range of beliefs can be debated in a healthy manner

Musk says a lot of things, some serious and others 100% trolling, and we have a hard time knowing how serious he is for any of them. Even as he’s addressing the main customers of his company, given his past and present behavior, we can’t take your quote at face value and assume any of it is meaningful (he’s saying that while reducing the moderation staff…)

My definition of “competent engineer” includes reading between the lines and making an effort to understand what is actually required for a job to be done. I don’t see any competent engineer joining on publicly shared empty promises.
Google's Open Source Hardware Dreams
At this point this is the only explanation that makes any sense. Elon Musk may very well be a moron who has been incredibly lucky until now.
The problem isn't the speed, it's the ridiculous bandwidth caps imposed by ISPs. Here in Canada a fairly simple 10GB data plan runs about $75/month, if a restaurant is offering me a discount and requires their 250MB app to get it, that discount has effectively cost me $2.
> Every “build” engine evolves from being a simple recipe processor

what if I told you it was every machine
If the business under new ownership turns a profit their bankers make money. If the business folds or is not turned around then the loans sour but the private equity owner also loses their money. In bankruptcy bond holders get paid before shareholders.
It tries to do something for me but fails, on Ventura.

Seems to just be a short script:

which man-preview
man-preview () {
man -w "$@" &> /dev/null && man -t "$@" | open -f -a Preview || man "$@"
}
Yep, sumerian cuneiform is ahead of me. Still have some books i want to read before that but i am certainly interested in reading the old text myself.
Those are certainly big problems, but I don't see how they lead to the company ceasing to exist in a few months.
> this can't be more complicated than producing 5 nm process chips

Chips don't randomly decide to unmake themselves: there's no active, living system you're interacting with.

The other thing that makes biology so confounding is its diversity. E.g. something that works without side effect for 100,000 people will kill 1 of them, because they were in some way different than the others.