skysight-inc/HackerNews huggingface dataset:
I had the same experience as the author when I first started learning about clinical trials from the perspective of the software world.

The amount of money invested in clinical trials and lack of visibility is staggering. We've companies that spend the entirety of their $100Ms in funding and not realized until month(s) after the fact when their accruals caught up!

A lot of it is messed up and can be improved. Indeed, we've have more demand than we can service since we productized what we're working on at Condor (https://condorsoftware.notion.site/About-Condor-d8a466f7722e...).

However, similar to what others have alluded, Chesterton's Fence is a relevant concept here (https://fs.blog/chestertons-fence/). It's critical to understand the rational reasons why the industry is so apparently messed up before you can fix them affectively. I wouldn't be working on the problem we're tackling today, if it weren't for my cofounder's deep knowledge across several disciplines in the industry.

One thing that continues to make a meaningful impression on me is the mission driven motivation behind so many people working in the industry of all levels. Consistently from the chief scientist to the entry level accountant you hear people talk about how they tie their work to the patients. Many software companies say they are "changing lives," many life science workers can actually point to saving them. It's been a big motivating factor for my cofounder and I to realize the same companies we are helping extend R&D runway are the ones making cancer drugs for some of those close to us.

Messy industry dynamics and backwards software means there are lots of BHAGs (https://www.jimcollins.com/concepts/bhag.html) to tackle.

Always down to talk shop on clinical trial finance, software, or ways to collaborate with good people whose interest this piques! Contact in bio.
Nice! You don't need the HTML and BODY tags though.

I think however this defeats the purpose: yes you're delivering the content as Markdown, but you have to deliver it as `text/html` for it to be rendered, so anyone fetching it can't tell it's Markdown content. Also every document has to have (invisible-ish) HTML junk appended

A "better" solution would be a browser that sends the `Accept: text/markdown, text/html` header and a server that serves Markdown only when requested.
malloc() isn't the issue, free() is. Allocate at init, never free, and you'll still have deterministic behavior and no heap fragmentation!*

* Unless you run out of memory, of course. Then you have issues.
puts incredibly nitpicky code reviewer hat on

Does the JVM allow using __attribute__ annotations? There's one for alignment, __attribute__((aligned(L1_DCACHE_LINE_SIZE))) (where L1_DCACHE_LINE_SIZE is defined by gcc -DL1_DCACHE_LINE_SIZE=`getconf LEVEL1_DCACHE_LINESIZE`) that could be used instead of the array, see: https://gcc.gnu.org/onlinedocs/gcc-12.2.0/gcc/Common-Variabl...
Not for cache line per se, but no runtime reflection means that any type information is static and won’t cause this kind of problem (+ no GC which is nice and makes leaks less likely). That’s a pretty significant RAM and performance saving and gets you within shouting distance of hand tuned assembly, especially since hot paths ARE frequently hand-tuned assembly.

I think that’s more what OP meant.

I’ll also note that while I don’t know what this service is doing, 300 RPS seems mighty low. That means each core is doing 30 RPS if you’re 12 wide. Maybe 60 since I don’t know what that 50% autoscaling piece means. Think about that. Each request is burning 16ms of CPU time. While I don’t know what this service does, this does seem like a lot when you consider just how fast a modern CPU is. That being said, it’s not impossible that even tweaking the Java code itself might unlock more CPU and that would be a more cost effective solution than using native code which is typically a bad fit for most web services (even rust).
Clubhouse lost its shine on its own. It simply didn’t scale on a social level and became a cesspool of crypto scams and conspiracy theorists looking for marks.
This keeps getting rediscovered in new domains.

JIT was the savior of manufacturing, until people learned that a single traffic jam that delayed a single delivery could create costs far in excess of the inventory savings.

Optimizations are critical, everywhere. And measuring optimizations is important because it is is easier and cheaper and earlier than measuring end results. Measuring days of inventory, or dollars in inventory, is a pretty good proxy for supply chain efficiency, until covid hits and suddenly “efficiency” means stability rather than minimum costs.

Over and over. Branch prediction / Spectre. Mortgage-Backed Securities. Optimizations based on second- and third-order effects blow up in the real world where any abstraction is approximate.

So it’s not the efficiency that’s the problem, it’s changing the focus from maximizing the desired output to maximizing efficiency, and measuring success based on the performance of efficiency optimizations.
But if it’s used for Wallstreet (which it absolutely is) why not the public too?
A public letter to Cloudflare to fix their snoopy vendor
"It has been speculated that the message was computer generated, with the text to promote its cheesy chicken being automatically connected to current anniversaries and events to stimulate sales."
Good for people with money, resources to know where to get the best treatment and live close by; bad for everyone else.

Disclaimer: I work at a giant cancer institution.
<i> for things that should be italic for visual reasons. For example, the titles of books.

<em> for things that are emphasized, as in emphatic expressions within text. For example "You'll get nothing and you'll like it."
Wow you are uninformed.

>The value of the tokens is completely and totally dependent on a consensus of crypto miners doing their job within the parameters of the system, assuming you want them to maintain a price and trading volume that's favorable to the token holders.

Number of miners has absolutely nothing to do with trading volumes, not sure where you got that from. Miners don't maintain a price any more than a whale maintains a price.

>If the majority of miners suddenly go bust due to outside circumstances

The rest of the miners would step in and start making more money, actually.

>they decide to conspire together and attack the system, or conspire with some whales to perform a rug pull

Not much of a rug pull to sell the tokens you've legitimately acquired through mining or fiat buying. That's just selling. High volatility selling, yes, but still just selling.

>it's extremely likely that your tokens aren't going to be worth anything anymore. This applies to every token, including bitcoin.

Oh yes, Bitcoin has died thousands of times. Maybe you'll be right one day, but I doubt it.
Don’t buy cheap eggs. The plastic is introduced via the feed, through vectors like expired bread products. There’s nothing wrong with using expired baked goods. The issue comes when they don’t take off the plastic wrapping and just let everything be shredded into the feed.

I do not believe grass fed chickens have the same problem.
If someone wins the lottery 4 different times buying only like 10 tickets in their whole life, you better fucking believe something special is going on there.

>How many people with musk's starting wealth have started businesses? Do you think every single one of them is less of a genius than he is?

Who are you talking about? Tesla and SpaceX dominate the markets they operate in. He didn’t take some family wealth and just maintain it with a business. He grew multiple companies from sub million dollar values to hundreds of billions.
Follow-up: Weirdly, it seems the backend for the archive feature is working fine - it's reporting what looks like a correct number of bookmarks, and says the backup is currently 51 GB, up from 30 GB when I last downloaded in July 2020. I guess there's an automation step missing (including throttling!), and then it could just run itself.
Brokerage houses and market makers do the same.
This is a really good video (albeit a bit too long, could have cut it in half), shame people on HN can't tell satire from reality.
idiomatic is certainly in the spec [1]:

The i element represents a span of text in an alternate voice or mood, or
otherwise offset from the normal prose in a manner indicating a different
quality of text, such as a taxonomic designation, a technical term, an
idiomatic phrase from another language, transliteration, a thought, or a ship
name in Western texts.

[1]: https://html.spec.whatwg.org/multipage/text-level-semantics....
It's the fastest way to purposefully destroy whatever culture has formed (arguably poorly if the company is in its present state), and then can quickly rehire based on new, arguably better, direction; risky bet IMHO to bet against Elon with his track record of making at least more good decisions than bad ones, so far, with Tesla, SpaceX, etc.
Not really.

The Board has a fiduciary responsibility to the shareholders. They can say NO to a "serious offer" only if they can claim with confidence that the offer is undervaluing the assets, or if there is another better offer. Neither was true for Twitter.
Apple plans to expand AirDrop time limit to customers worldwide
Not only that but the owner is tweeting hateful images and articles with misinformation.
GitHub introduces an all-new code search and code browsing experience
So what does it mean if you have <i> around Chinese

There's actually a tag for this. I can't remember what it is, but it puts dots above the ideograms, which serves the same function.
Because economies of scale win. Centralizers can consume all available oxygen first, it doesn't matter that they can then go belly up.
Well, for one, Twitter is under a 20 year consent decree with the FTC and all of the relevant leaders in charge of this resigned this week and individual twitter engineers now need to "self certify" that they're complying with the decree.

People who have intimate experience with just exactly the degree of latitude the FTC will allow for twitter and have a personal relationship that allows them to negotiate with the FTC isn't exactly a skill you can just find on the street.
I listened on it and was definitely good and very eye opening. The delusion does seem surreal
I don't doubt that some people will spend as much, that's not hard. My point is that most definitely don't. Most people don't buy $15 bags every week. Hell, instant coffee is something like 20% of the whole market by revenue, and considering how cheap it is compared to quality coffee, I think there are more people who drink Folgers than those who spend $1000/year on coffee.
It is about the 10th time he jumps into something thinking he has some brilliant insight that everything is simpler than everyone else is making it out to be. He seems to be wrong every time but somehow it hasn't caught up to him yet.
What do these people think about blocking abortion clinics?

(Aside from "Our blockages are done for a good cause, abortion clinic blockages aren't.")
It's still pretty much the go to place for journalists to mine quotes and sentiment from "normal people".

I'm addition, it remains a significant platform for informal celebrity and corporate announcements.

People in tech are pretty bearish about Twitter these days (myself included), but there are clearly a significant number of people who believe otherwise.
I did it through 'multiprocessing' and a Pipe. Works fine but challenging shutting everything down when the child process throws an exception.
For reference: https://www.theverge.com/2022/11/10/23451198/twitter-ftc-elo...
Should be doable with nb - https://github.com/xwmx/nb#-bookmarks

Each bookmark is saved as a markdown file so syncing is straightforward. I mainly use it with the command line interface but you can also use a UI running in the browser.
A lot of businesses reasonably use Python and Ruby, for example.
Of course it is funny to look at a committee trying to invent some grand vision for something that was simply a small set of options available on desktops around 1990.

The real problem, however, is that many writing systems have never had any kind of oblique style for emphasis. Or cursive (which is a different thing). Or they have cursive, and use it all the time in print, but technically that's a different font without any connections to the main one. So any person making some kind of template should be aware that the effect of <i>-as-italic can range from “obvious thing everyone expects and understands” to “does nothing at all” depending on language and font. I think they should have got straight to that point in the article.

It is pitiful how those unreflected small choices can put fences in one's mind. Everyone knows the font selection dialog in the browser, and probably thinks that the world is made of serif, sans-serif, monospace, and some Comic Sans. But that's nonsense, even for Latin.

Even more pathetic is inability to use basic punctuation marks. Something as barebone as Fixedsys font had all the quotation marks and dashes since Windows 3.1, long before programs became Unicode-aware. All that time absolutely nothing has been stopping you from pressing the key and getting the proper symbol just like you type any other… except the typewriter key labels hardware makers still use, and the default system layouts being just as stale.
Building Offline First Applications with AWS Amplify DataStore – Part 1
Yep Coinbase is traded on NASDAQ and is subject to heavy regulation and reporting.
Any chance you could share what your company is? I'm in the energy space and always interested to see what Energy Storage solutions are getting funded.
Totally on board with flying in the outboard cheap seats, at least for any flight where I don't have to sleep. Flights are incredibly boring aside from takeoff and landing, and I love roller coasters. :)

I have a feeling there are enough of us to make it work in the market and still fill planes, just instead of first-business-coach going front-to-back it'll go center-out, like a theater.
Great comparison. I am working on Savory which tries to keep it very simple and might be interesting to folks looking to jump off Pinboard: https://getsavory.co/. There is a chrome extension to save links and tags are a first-class citizen. There is no support for archiving or sharing yet, but it is something I want to add soon.
Well then this is a solid argument for “No regulation” being an undesirable feature of crypto and a win for Americans.
I think those figures are wrong. Here's another source, suggesting the spending is $250 per capita, and 90% of that spending is out of home. This necessarily implies that people who spend more than a few hundred dollars per year on coffee beans, like some replies suggested, are a tiny minority.

https://www.statista.com/outlook/cmo/hot-drinks/coffee/unite...
If you google "deepmind protein folding", among zillions, you get this:

https://www.future-science.com/doi/10.2144/btn-2022-0007

If, OTOH, you add "criticism" to the query, among lots, you get these:

https://occamstypewriter.org/scurry/2020/12/02/no-deepmind-h...

and

https://www.lesswrong.com/posts/6vybojuDEqaHeg8aN/a-confused...

To be clear, I'm not trying to cherry pick "bad news"; I've been following DM for years;their work is nothing short of astounding, but what the MSM does with their work seems to reach beyond the bounds of actual fact. Sad - really - to see Scientific American land at such a low level of critical thinking. It's not the SA I grew up with anymore.
FTX's 'Effective Altruism' Future Fund Team Resigns
A lot of large companies have used twitter to announce some new product launch of marketing initiative. With the recent spate of fake blue checks like "Nintendo" posting Mario giving the middle finger or "Eli Lilly" posting insulin is now free or "Twitter Blue" announcing free twitter blue if you buy an NFT, I imagine many are rethinking this going forward.
Why should my son repay his student loan? Why should anyone?

They should just default, and someone like you will pick up the bill.
BlockFi halts withdrawals amid FTX turmoil
Nonsense. If that was true then things like backups and cloud sync couldn't happen when the device is locked. But of course they do, meaning the keys are still sitting there freely accessed by the CPU, along with all the data on disk.

Your camera example is not at all convincing of anything special going on, since that's also the camera behavior of other OS's (like Android) that don't purge the keys. That's far more easily implemented as just a basic app policy than some security system that yanks the file system out from underneath running processes.
No amount of technology will solve a problem that has been caused by technology to start with. There are too many people consuming too much on a planet with finite resources, but no one wants to be the one to change first. So, even if technology can save us, at the end of the day, it's mostly societal problem anyway. At some point people will need to embrace the idea of collapse.
What do they intend to do with them?
Site is kinda dying (at least in my region of IP) but I looked up .sarl: it's like .gmbh or .ltd but French.
This is the naive approach you would do 15+ years ago.

Then things got way better with real browser engines like Webkit that could understand Javascript. That was something that I've personally hacked together as a contractor for an anti-piracy customer using Python, Webkit and Qt framework (PyQt) in around 2009. Shortly after some nice libraries in node/js came out like Phantom.js which would make this much better.

If I were to do this today, I'd use Playwright.
Ah my memory is blurry in the specifics. I think the issue was then that the archived link never showed up. Definitely it didn't work. I checked an rechecked the FAQ to make sure that in fact it wasn't working for me, and it wasn't that I didn't know how to use it.

--

Actually... I just checked my emails. My account never upgraded after payment (it was still standard) and the check-mark didn't appear next to my links. And of course there was no way for me to see the archived page or request an archive backup.
Dagger originally started with CUE, and is still powered by it under the hood, which has the constructs you mention, while also being turing incomplete.

I don't understand this move to define infra and CI imperatively, and tool vendors moving to support umptine languages for their users... Say what the world should look like, not how to get there?
Even this one? “ you die and haven't gone through the complication of setting up a way for your heirs to gain control of your accounts.”
I’d strongly suggest you make that available as large orgs will require such. This may also help you offset the need for local installs.

By the way,
1. export as in csv. On demand or schedule.
2. Backup in your saas in whatever makes sense with ability to restore.

Backup is only useful with restore

Edit: spelling
If a single individual controlled all customer assets then that is the issue. No institutional checks and balances.
I have no idea what you're trying to say. Yes it's not "just physics" that causes the FCC to regulate the content of broadcasts on radio and TV airwaves. I thought that was obvious.

Even if the FCC chose not to regulate broadcast programming, they or some other body, would still need to enforce rights to frequencies. That's their raison d'etre. Content policing is an added function, which the law has found valid in the past precisely because frequencies are limited. I can't see such public interest legal opinions being newly formed today.
It’s not “too busy”. It’s that unless you have significant scale, the return for improvements like this are often not worth the engineering time. At companies with massive scale (read: large enough), even tiny improvements can pay for themselves.
That wasn't all that similar:

https://money.cnn.com/1997/03/14/technology/apple/

It was a smaller fraction of workers (30%) and was the third layoff in the past year, with the previous two happening before Jobs had even rejoined the company (and he wouldn't become CEO for 6 more months, though likely he was shadow CEO only 4 months later).
Well thank you for the anti-recommendation! I’m looking forward to reading it. I get that it wasn’t your thing, but your description sounds very much up my alley and I hope I can enjoy what you didn’t.
The Guardian:

"A person familiar with the dealings between FTX and Binance described the books as a “black hole” where it was impossible to differentiate between the assets and liabilities of FTX and those of Alameda Research. This person spoke on condition of anonymity because they weren’t authorized to speak publicly about the matter. This person said Bankman-Fried had committed the “ultimate sin” by tapping into FTX’s custodial assets to fund Alameda Research."[1]

There are people trying to blame Binance for the collapse. That's bogus. If FTX was stealing customer funds, it's entirely FTX's fault.

Interesting info: Bankman-Fried owns part of Robinhood Financial.[2] Which will probably be audited real soon to see if he somehow took money out of there.

This is the kind of thing prosecutors refer to as an "ongoing criminal enterprise".

[1] https://www.theguardian.com/technology/2022/nov/10/ftx-crypt...

[2] https://fortune.com/crypto/2022/11/09/the-winners-and-losers...
Zeihan is one of those commentators that seems to throw a bunch of wild predictions at the wall to be entertaining, appear insightful, and be able to say he called it when one of every dozen ends up being correct.
I've had a good experience with this[0], however it seems Eric is not currently running it, if you're interested, email me, I can dig around and see if I can find my notes.

Alternatively reach out to him in an email and see if he'll be willing to let you buy access. I personally found it a pretty good course where he had spent a reasonable amount of time coming up with both decent examples to highlight how it was going to work as well as create some nice rules of thumb as starting points to think about properties.

-[0]: https://ericnormand.podia.com/beginning-property-based-testi...
Amazon ships more packages through its DSPs than anyone. But I don’t see them doing delivery as anti-competitive. It is highly integrated and streamlined however.

They put a absolutely massive amount of resources on solving delivery. And they probably do it better than anyone. You couldn’t split that out without totally breaking it.
Yea strange, same thing when he warned Germany of Russian oil/gas dependence. The entire world mocked him.

NYT wrote a whole thing about how banning Tiktok would hurt creators and advertisers: https://www.nytimes.com/2020/08/02/style/tiktok-ban-threat-t...
Professional software development is a grotesque field
This service was pretty sweet until around when the pandemic hit and then they stopped serving flights that didn't originate out of the USA which was really annoying. I don't know if they brought that back up yet but it was enough for me to give the service up. Is there anything comparable?

You'd think that this is the kind of thing which would be insanely easy to automate.
If they wanted people to use a different tag for such text, they should have created an idiomatic tag instead of attempting to repurpose existing ones.

If you read the spec, it mentions several different uses for <i>, depending on the context. Otherwise, we’d need a different element for each context, bloating the spec by having special purpose elements instead of general ones.

For example, <i> is used for ship names:

<p>They came over on the <i>Mayflower</i>.</p>

It wouldn’t make a lot of sense to have an element just for names of ships in a general purpose markup language like HTML.

Turns out, if you look at the Wikipedia article about the Mayflower, the name is marked-up with the <i> element [1].

[1]: https://en.wikipedia.org/wiki/Mayflower