skysight-inc/HackerNews huggingface dataset:
Would an atomic mutable subclass cache (not sure what it's used for, downcasting?) be unnecessary in a language built around static rather than dynamic dispatch by default, like C/C++/Rust and perhaps Go? Or would it still speed up dynamically dispatched code, but is less practical or worthwhile so it isn't used in practice? (Though Rust's Arc also suffers from atomic contention similar to this blog post, when used across dozens of threads: https://pkolaczk.github.io/server-slower-than-a-laptop/)

Also it's somewhat ironic that the JVM source code (https://github.com/openjdk/jdk8u/blob/jdk8u352-b07/hotspot/s...) says "This code is rarely used, so simplicity is a virtue here" at the site of a bottleneck.
This is an ongoing discussion in CAR-T. At the moment we only have 'autologous' CAR-T, which means they are manufactured from our own cells. The big advantage to 'allogeneic' CAR-T is that we don't have to take the time (several weeks) to modify T cells for adminstration, during which patients can die of the disease. 'Off the shelf' would be preferable, but there are lots of problems with trying to use someone else's T cells for the job.

The main issue is that our immune system is very good at removing non-self, so a lot of work would need to go into stopping the immune system doing this.

The article isn't talking about CAR-T though, rather TCR-modified T cells. These are very patient-specific because we have a unique MHC signature (this is why we have to find a 'match' for a transplant recipient). Previously people have taken the T cells from the tumour site, boosted them in the lab, and re-infused with some remarkable and curative results. The outcomes in this trial weren't so great but it is novel to splice in a new TCR.
> These posts both make me violently aroused as well as profoundly depressed basically every employer I’ve ever had in 30 years doesn’t value such analysis.

Couldn't agree more, except on the timeline. In my experience, the 90s and most of the 00s proper engineering like this was the norm in silicon valley and I loved it. It's the last 10-15 years that PMs have taken over and now it's all so superficial and uninteresting. I've moved away from hands-on development work because nobody is doing anything intellectually rewarding anymore. But I wish I was doing hard-core engineering like it used to be.
OP here: I don't see why you'd be downvoted for this, it's a fair point!
I agree with each of your three points, and in response I'll change the requirements a bit:

How can I get 1 dollar to as many people as possible, while spending the least amount of money on transactional costs or fighting fraud/corruption?

I think all of the edge cases you named above can be dealt with given this new requirement. Some fraud and corruption will happen for sure, just like with any financial transaction anywhere in the world. I would say that fighting fraud/corruption is only worth it, if the cost of fighting it is less than what you'd lose to it if left unchecked. A dead grandma will be too expensive to disprove, but someone making thousands of fake personas must be detectable somehow, such as re-using the same bank account or adress a thousand times.
I believe he also said after the next election. Wants to build political capital first, apparently.
I think there is a game system from these colourful pyramids as well
>but 1 it isn't what he/she/them ask (ask for legislation and policies)

Exactly, the problem is asking for law/policy/regulation to solve the problem when it is the problem.

In the words of Cypherpunk and EFF Founder John Gilmore:

“I want a guarantee -- with physics and mathematics, not with laws -- that we can give ourselves real privacy of personal communications."
How to remove a wedding ring from a swollen finger [video]
WeChat is the bigger threat as it gives the CCP direct leverage over it's userbase. Everyone forgot about that though since it doesn't affect anybody outside the sinosphere.
> Private isn't a useful distinction though right?

Yes it is. If code is public you can't necessarily use or copy the code (depending on the license) but there's nothing stopping you reading it and learning how it works and any secrets contained in it (e.g. information about future products).

There's a reason most proprietary software isn't "source available".

> If you sell a product which can regurgitate large parts of code who's licence doesn't allow it to be completely freely used and modified

Yes but they don't do that. I'm not sure why people are finding this so hard to understand.
Would stripping binary symbols affect stack traces in crash reports?
Actually, there's an app that does that : Joplin from https://github.com/laurent22/joplin

you can publicise the markdown text that you're writing in markdown. here's an example with my joplin server and with the desktop app running on linux. I get this link : https://joplin.mehdiguiraud.info/shares/8YBjIJwoNh15uVY900xq...
If you mount an decrypted file system from another user, doesn't that make it inheritly read only if you are not a super user?
At the very small end of the scale this is very true. It doesn't take too much traffic volume to make it worth it though. It's just difficult to make anyone care. It doesn't take a particularly huge amount of traffic to make it worth spending a few weeks of engineering time to save $50K+ on annual hosting costs.
The title just mentions microplastics, but the first line of the article says:

> a way to turn your breakfast food into a new material that can cheaply remove salt and microplastics from seawater.

So salt too? Isn't that way more impressive than microplastics? Could this lead to cheap desalination?
If all travel were like the Eurostar I’d be doing a lot more of it. Honestly feels like you get there before you’d even be on the runway with flying.
Crucial to this piece is "blocking of supply"; unfortunately there is no explanation of what this actually means.
They did and still do provide precompiled wheels for cryptography. The problem was the version of pip distributed by some of the major Linux distributions was too old to understand the newer tags that would have told them to use the wheels. Because of this I agree that they probably jumped the gun on making the switch but if you had a new enough pip you don’t need to compile it.

On the plus side it gave the impetus for Python to define wheels for musl and other arch’s which is a nice outcome.
This seems like a really cool idea! Making it easy to do good is almost always a wise choice.

Personally, up until now I've been subscribed to Wren to offset some of my personal CO2 footprint and get a little bit more educated about climate adjacent topics: https://www.wren.co/

It's not really something you'd use in an automated fashion, but rather a yearly subscription, so not comparable against the solution in the post 1:1, but it still might be of interest to some.

Of course, one can also talk about the impact of personal decisions vs those of corporations and the need for legislation and so on, but I'll take what's achievable for me, even if I do a little good.
"safe" doesn't mean "cannot go wrong". See terms such as safety belt or safety shoes, no one expects those to be infallible. It's simply an extra layer of defense.
Well, their largest asset was probably their own token. Once that went to zero, maybe it was Bitcoin, but I doubt it. Tether more likely.

Remember, this was a casino, not really an exchange.
Aave withdrawals of DAI stablecoin has been unaffected by the greed of SBF, and unaffected by the speculative price swings of Eth or Bitcoin. You personally may not consider these assets, but many do.
>I started Postcard when I deleted most social media

Postcard feels like a better social network that isn't allowed to be. Could you imagine to implement ActivityPub so that accounts can be directly followed?

>full-text RSS feed

There is only "Subscribe to my updates" at the bottom. Where can the audience see that an RSS feed is available?
Here's a slightly-critical bit...if you wanted to do this at massive scale, without inducing massive starvation:

> "Eggs are cool because we can all connect to them and they are easy to get, but you want to be careful about competing against the food cycle," said Arnold. Because other proteins also worked, the material can potentially be produced in large quantities relatively cheaply and without impacting the food supply. One next step for the researchers, Ozden noted, is refining the fabrication process so it can be used in water purification on a larger scale.
Twitter adds a second check mark for “official” accounts
I think Ken Thompson gets little respect precisely because he designed Go. It's a large stain on his legacy that has single handedly set back the field of Software Development.

I think that if Go didn't exist he would be considered "one of the greats".
I strongly doubt they shred the plastic packaging into the feed. That said, plastic is already in everything. It's in our blood, in the placenta of fetuses. I think you'd be hard-pressed to find a chicken that doesn't have microplastics in its blood.
Yeah, I haven't considered data caps, as here in Hungary, unlimited data is around 27eur/mo, but even capped is not that expensive (just an example: 10GB is 10eur, 50gb is 20 eur)
There is no known polynomial time algorithm for TSP. AFAIK there are quantum algorithms for TSP with quadratic speedup in comparison to the brute force method (still exponential though).

The one thing quantum computers are (currently and theoretically) able to solve efficiently is the factorization problem, but are very much limited by low qubit number, i.e. engineering problems.
Ah, right, sorry, I haven't considered data caps.
A commander doesn’t have to go overboard due to the nature of their work. That’s no different than a CEO who happened to have a heart attack while being CEO.

Lookup James Po Ho Cheung or Sid Agrawal if you want examples of CEOs straight up murdered for their roles.
So when bond holders come by wanting their money do you not give it to them (defaulting) or do you just issue more (inflating)? Because those are your two options.

Note also that investors eventually get wise to inflation and start putting their money in gold or somesuch.
https://en.wikipedia.org/wiki/Confidence_and_supply

Confidence = voting for the government in confidence motions (or votes which are not explicit confidence votes but considered to be "matters of confidence"). Supply = voting for the budget (because if the government can't pass a budget, then it is considered to not have the confidence of the house, and has to be replaced).
I had to switch back to iOS. My smartphone is my primary camera and I missed lots of important shots because the Graphene camera was so slow to double click launch from locked (on a flagship pixel $LATEST pro max whatever).

I really miss syncthing.
The issue is that it's very abstract, and all the mechanics of banking are accounting operations, whereas people don't tend to think that way. The deposits themselves are entries on the liability side of the bank's balance sheet. The bank doesn't store money for customers, they take whatever asset you give them and give you basically an IOU in return. So the "customer deposit" is not what you gave the bank (say if you deposited cash), it's a number in a database. Just like what is 'in' the bank's exchange settlement accounts at the central bank (e.g. Federal Reserve), and just like what is moved around in international finance. Electronic messages representing IOUs.

This is balanced by a mix of assets, which are a whole number of things. A tiny amount of cash, a small amount of central bank reserves, some in treasuries and bonds, and the assets created by the bank loans, etc.. (When the bank creates those loans, they create new deposits and a new asset in the loan, in equal amounts. So the assets and liabilities of the bank increase but the balance is zero).

So if the bank gets in trouble, it's because some of the asset mix has declined in value (like too many people have defaulted on their loans) to the point that the assets no longer cover those liabilities.
Presumably because Amazon is such a notorious neat grinder in how it treats its "boots on the ground". They don't exactly have the goodwill necessary to shake it off since mkst people's relationship with them is out of convenience rather than fanaticism. Also unlike some brands with the ability to conveniently ignore where or how their unsafe/underpaid sausage is made (in China) they also get shit for squeezing the hell out of their workers domestically where they can still complain about the mistreatment publicly.
There was a time when people used to say these things about conventional computers, remember the 50s?
I don't understand how it can ever be acceptable for a company to risk its customers' deposits, regardless of what kind of company it is (bank, exchange, whatever).

There should be a law that states:

1. Depositors are the most senior creditor (ie. they must be paid first, before any other creditor)

2. Investing depositor funds without explicit approval is a criminal act (because it's essentially using other people's money for your own interests)
Disproportionately annoyed by inserting a whole cache line of padding between the variables instead of just enough to move them to different lines. That's probably just to make the blog post simpler though.
I paid for Pinboard for life very early on, and remember getting an email a while back encouraging everyone to pay for a subcription instead so that development could continue.

I wonder if that didn't work out somehow, and revenue wasn't enough to encourage development/maintenance of the service. I've not logged in for years though, so the site's not been on my radar until today.
Just in case somebody missed it from the article, there is a 1-hour long youtube video about the same issue: https://www.youtube.com/watch?v=G40VfIsnCdo
Well I’m not sure what I did wrong but I seem to have caused a wave of negative emotions. I guess I have a lot to learn still.
Something like 20-25% of all launchs globally doesn't seem like a small fraction.
Thanks.

I raised the question, because i want to understand, how much police in France needs to do to issue an order to unlock a phone. It does not sound too bad to me, if they have to go through a judge and a hearing to issue the order.
It seems to me to really understand rock science, you need to know physics.

As you state, that is not the case for CPU design.
My first impression is also in agreement with the parent. The blog post appears to use some terms loosely in order to make the connection between overfitting and Goodhart's law stronger. For example - calling training sample "proxy" and stating that it is is a slightly different goal is already leading towards the pre-defined conclusion.

And the reply also leaves me with a similar impression:

> your training objective can be different at train and test time

But this is not overfitting, this is concept drift, a different and well-defined thing in ML.

> the datapoints you use can be different at train and test time

Both train and test data came from the same population. They are just different incomplete random samples.

I guess what I am getting at - overfitting happens because we know we are training a model on an incomplete representation of the whole. But that representation is not a proxy, as suggested in the article - it is not slightly different to the goal. It's an incomplete piece of the goal.
This particular misspelling happens often enough (on this forum) that I don't think it's unreasonable to think that some people are doing it intentionally as a form of trolling.
OP is talking about CAR-T therapy which is in routine clinical practice. In the UK costs have gone from £600k to around £250K That includes the surrounding medical, nursing and follow up care. In the US costs are likely to be more than that.

The article is talking about a very bespoke process where they take a patient's cancer, sequence the whole thing, select mutations they think will be presented on MHC-1, predict the antigens visible, and 'somehow' (I need to read the article more carefully to figure out how they did this) select a TCR sequence which will bind to that. Then they use CRISPR to graft that onto the TCR gene of a T cell from the patient (3 types by the looks of it), and re-infuse the targeted cells.

So yes, that would cost several million.
The narrative seems to conflate the Palace and the Queen as being one and the same.

The Wikipedia article on this is less... certain, shall we say. [0]

We always knew that there was correspondence between the Governor General and the Palace, because after all, the GG is the representative of the current monarch, when a GG is going to wade in and cause a constitutional crisis, I'd expect there to be such correspondence.

But calling it the "Queen's Coup" is overegging the pudding.

It was very much John Kerr's Coup.

And for fun, there's lots of salacious rumours that the CIA and UK's Foreign Office were encouraging the removal of Whitlam because he was perceived as too friendly to the darn Commies.

[0]: https://en.wikipedia.org/wiki/1975_Australian_constitutional...
So like non-alt hierarchies on Usenet?
You claim that the bank needs no existing customer deposits to create a demand deposit and liability in your account. This claim is true only in the pedantic sense: if the bank is otherwise capitalized (e.g. money from investors in the bank), then it could create loans using whatever money it has, as opposed to using money specifically from depositors. However, what you probably meant is that a bank could loan out money even if it has $0 money in the bank. This is not true at all. A bank can not loan out money if it has no money. It has no printing presses that print physical banknotes, and other banks would refuse electronic transfers from a bank which is known to have $0 money.

Furthermore, it's not clear to me how you believe that the BoE article contradicts what I'm saying. I'm under the impression that you (along with most other people) are simply misunderstanding what you are reading here.
US healthcare really does put a new spin on the term "life savings".

Here in the Democratic People's Republic of Sweden healthcare is government funded and universal.
> Custom building T-cell receptor proteins [0] capable of recognizing those targets

How does this part work? Is this some sort of selection of cells in the lab, or done in silico?
The ships are so big, expensive, and slow to build that each one varies by request of the Navy and necessity (suppliers change, shipyards are different, parts are substituted, timelines cut optional components, etc).
Then you can put it in a computer and give the law even fewer tolerances for human compassion or interpretation.
Man you must like some adventure.
In Australia, legislation needs to pass through both lower and upper houses. In this situation, the opposition party was able to block crucial legislation from passing through both houses and into law. If legislation is repeatedly blocked, it may lead to a double dissolution [1] of both houses where all parliamentarians require reelection.

[1] https://www.moadoph.gov.au/blog/double-dissolution-what-is-i...
Small planes. The exact same plane from the 1970s costs 4x as much.
Talk about a tangent.
Naturally, I'm downvoted to oblivion for pointing out that they bought Figma..
You could say it's a source code distribution model, as the name suggests.
> Boot chain is typically Firmware → shim → grub ...

Is this really true? Or just when using Red Hat systems? I don't know too much about the boot chain, but I always thought that after the ROM stage, usually GRUB would take over directly from the UEFI.
My take is as follows: we don't look much at our keyboard while we use it, so the way it looks is not very important. The exception being the moment your learn (learning curve) your layout.

What is most important is how it feels. How do the keys feel, how does typing feel. Another thing which is important is if its durable.

Which is why I went with a durable, mechanical keyboard and I plan to lube it to make it a bit more silent.
Yes, and the vision pitch for spacex early one was exploding rockets if you’re that myopic.
The bit I really loved about this passage when I first read it, because it's so clever, is that of course these people with a space-faring culture assume that Unix time was based on the date we first landed on the Moon.
There's no way to update the firmware on these devices, at least not without soldering on a connector first.
Kate Editor Is Getting 4 New Features
Why is unity important to us?
I've definitely experienced this trap first hand, transforming a web app from a monolith to a distributed app with a ton of bells and whistles. I think having some years of experience under your belt transforms you from longing for complexity to striving for clean and simple solutions. Especially if you're also responsible for moving the project forward in the long run.
Why this AdBlue thing is called so fancy if this is kind of common (not rare, easy to get) substance?
> If you're not a citizen or green card holder they'll also send you packing for invoking the few constitutional rights you have at the border.

Yeah they're not exactly rights if you're penalised for using them.
Sometimes availability is more important than safety. Let the patient decide if they want to take the risk, just mandate they be informed.
The Car Safety Feature That Kills the Other Guy
TIL there are ".ford" and ".lincoln" TLDs

https://ipinfo.io/AS3389#block-domains

https://nic.ford/

https://nic.lincoln/
Public key encryption perhaps?

Private key for encryption, public key for decryption. You give the authorities the public key, they can't plant any data with it.
Texas counties theoretically email ballots if you send in your overseas voter request each year, but it’s theoretical, because at least my county doesn’t set up their email domain correctly, and thus doesn’t even make GMail’s Spam folder.

Email domain is a subdomain of *.co.texas.us, so it’s probably a state-level issue, but the IP address in the ballot download URL (yes, IP address!) is in the same range as the county’s other websites.

Oh, and the county’s main website is geofenced, so the only way I can get contact info for the elections office is using my Hetzner VM in Virginia as a Tailscale exit point.

Why do I get the feeling that the State of Texas, or at least my home county, is not interested in my vote?