skysight-inc/HackerNews huggingface dataset:
Comprehensive accessible review here:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495366/

The virus apparently just wrecks the immune system right off the bat, allowing it to rampage throughout the body unchecked. Hence immune-system-support therapies are being worked on:

> "EBOV is able to evade innate and adaptive (both humoral and cellular) responses by encoding for multiple viral proteins that inhibit both type-I IFNs synthesis and response, by masking viral epitopes by glycosylation processes, by deregulating inflammatory response, by preventing DC maturation, thus resulting in a catastrophic failure of innate and adaptive immunity. Thus host factors have a key role for viral replication and release, and may represent good targets for therapeutic strategies."

The for-profit pharmaceutical system isn't that interested in this, as not many people or governments in Africa have the funds to pay for research, production, and what is it now, a guaranteed 15%+ profit margin?
> He just wants split government, so that's why we should vote straight ticket republicans now.

If more people would do this things would be less insane.

When we vote in Aus we vote for the House of Representatives and the Senate at the same time (though the senate terms are longer) and I've never voted the same way on both for that same reason, it's harder for them to pass crazy shit if they have to compromise with each other (that's the idea anyway, in reality both our parties love to implement authoritarian bullshit)
Agree with the advice. If nothing else, be kind and respectful of people facing adversity.
Some elements of the crypto space may not need to be regulated, but centralized exchanges should be regulated as hard as banks and should regularly undergo liquidity stress tests. If FTX does turn out to be insolvent, execs should be getting more than a slap on the wrist
> we gays know how bad diseases can get, and fuck it my dating life even after 2 years of pandemic is not as important as is my life

That's a nice sentiment I guess. Meanwhile my gay friend didn't stop "socialization" during the pandemic except first few early months. According to him he must've had COVID at least 4 times by now. If you add natural immunity, vaccine and asymptotic transmission he was getting exposed to COVID pretty much all the time.

This is nothing against gay community. This is against idolozation of certain communities and demonization of certain other communities to fit certain political narrative. Reality is more complex and nuance.
Lets say I instal Python package for IBM I, I am sure that the standard library is supported.

How many Rust packages work on IBM i?

IBM i was a random example, there are plenty of platforms out there.
Moreso than that, imagine a rubber duck floating in the water: silently looking at you, nodding in understanding.
Well someone doesn't like cyclists very much.
Where do you get your recordings from?

It bums me out that most music recording and reproduction equipment drop off drastically outside 20-20,000hz. I wish that we could open that range up a bit more, the low end for haptics and the high end for the other beings in our house that can hear in that range (dogs, cats, etc)

The new amplifiers from Purifi are incredible when it comes to delivering a flat response to 0hz, at high power into complex loads.

I’m curious to see if I’ll be able to tell a difference in how their amps coupled with their new power supplies drive my ButtKickers :)
I thought maybe mobile OSes might have a decryption sandbox, so apps could manipulate keys without having full access to them.
Why don't the Democrats organize to get them ID? It would seem like a no-brainer get-out-the-vote initiative.
Doesn't seem odd for news outlets, unfortunately.
What is 45 then
In a collision that rends a metal car frame, I think all flesh would move. Crash test dummies don't simulate this aspect of collisions.
I think they’re probably referring to https://en.m.wikipedia.org/wiki/Rubber_duck_debugging
If you unfollow everyone you don't see ads ever again.
You just have to visit your friend's profiles one by one (or whatever group of friends you have created) to see their unaltered feeds with no ads.
Very cool! I think notifications could work on android without an app via browser notifications from the website, if they don't already.
Giving them the benefit of doubt, this is not a contradiction. The statement means that they have enough illiquid assets to cover the withdrawal that they are working on converting into liquidity.
It's a statistically confirmed reality of substance abuse in our industry.

I posit 2 factors.

1. You can readily do it while doing your job. If you're in a factory with both hands building the widget or on a roof nailing shingles. Your hands are too busy; but with IT? 1 hand on mouse, other hand on beer bottle. Sure construction workers aren't sober angels, but they aren't as inebriated as IT.

2. The inherent negativity of the industry. Many jobs are about 'fixing something broken' and tickets and new 0day and we have to patch. Generally speaking the industry is something negative. When dealing with negativity dayin-dayout it takes a psychological toll which nobody addresses appropriately.

When these 2 factors collide, they feed into each other.

edit/ Sorry, didn't figure my posits would be so controversial. downvoted quite heavily.
its related to tech and the valley
I'll upvote any post beginning with "get a sheet of rubber" :-)
Also a common misconception that hardcore punk bands only play power chords. A lot of bands are playing barre chords and hitting all the strings (imagine!). I learned most of the songs in the examples that way--whether the original guitarists did or did not, I don't know.

Full disclosure, I am a self-taught, punk musician with minimal knowledge of music theory. But most hardcore punk songs are just pop songs sped up, so I don't see how one can have a chord progression and the other can't.
It is anti-democratic to have open ballots, because then people are not free to vote their conscience.
Really nice!

I like the design choices of Datalog for the query language and Relations for the data model. This contrasts with the typical choices made for graph databases where the word graph seems to make links a mandatory query and representation tool.
> First off cycling in such a place is utter insanity and is resolved by dedicated cycle lanes and paths.

This is infeasible in Amish country, where there are lots of long stretches of straight roads with high speed limits.

You’re entirely correct about what the law should be, and at least in PA, that is what the law is. Those of us in Amish country are also used to sharing the road with larger slow-moving vehicles like buggies and farm tractors. I treat a cyclist the same way: follow at a safe distance until I can pass in the opposite lane, like the law says. It’s unfortunate that enough people are failing to do so that as often as not I get a friendly wave, when I eventually pass, for simply being a responsible driver.
Now that I think about it, some parts of ASP.NET do a lot of stuff behind your back so the concerns that Dan Palmer brings up in a sibling comment may be worse than you think...
> * Very very low traffic apps. POST hooks for Slack bots, etc.. Works well!

I would add, that it offers an extension point / hook-in for a variety of AWS products. I can add custom functions to be called when a Cognito user is created, updated. I can add custom functions to be called to authorize routes transiting API Gateway.

At "The Firm" - we're going heavily in on AWS for our architecture - Fargate for k8s on top of the usual RDS, S3, etc.

We've begun roll-out of an external-facing API authenticated with OAuth2. Our backing store here is Cognito and our routing happens via API Gateway. We use the API Gateway's baked-in Cognito token authorizer for incoming requests, which route to pods hosted in Fargate. These pods represent a variety of projects.

As such we have two Lambda functions providing the /oauth/secret and /oauth/token endpoints for exchange of One-Time-Password for a secret token and secret token for access tokens - they experience very low N call rates (dozens?) of times per day and don't fit into any given API we host via Fargate.
Those specialized tools cost between $20 and $100, depending on the brand and whether you want pro-level "do this several times a day" quality, or end-user "do this once or twice a year" quality.

Hardly "so expensive no amateur will afford them".
Speaking in generalities rather than specifically about Postgres/PostgresML, this is how you should think about speccing hardware to solve these kinds of problems:

A DBMS that does mostly point-query reads — fetching single "cold" rows from a large storage, with high concurrency — is an IO-bottlenecked workload. Given a sufficiently mainframe-y "DMA from disk straight through to the NIC" architecture (which modern microcomputer servers are rapidly approaching), the CPU is just "guiding" that transfer — acting as a PCIe switchboard operator — rather than actually performing it. The only things you need to worry about are JBOD IO-queue depth and (multi-aggregated) NIC total ring-buffer size. This means that you can go very far with "vertical" scaling for these workloads, in the sense that you can shove more disks and NICs into the same machine and it'll be able to serve more RPS, without really increasing CPU load. For IO-bottlenecked workloads, you only start to suffer when your PCIe bandwidth is exhausted. This is why systems built for "SAN" or "DB" or "hyperconverged" use-cases like this always use dual-socket lower-cores-per-socket CPUs (lately: dual Epyc 7532s) rather than single higher-core-count CPUs — as each socket gets its own PCIe channels, so the lower-powered dual-socket CPUs actually maximize PCIe bandwidth per machine.

Meanwhile, any kind of ML prediction is going to be a CPU- (or maybe GPU-) bottlenecked workload. If you have 64 CPU cores in a machine, then you can only be doing 64 ML predictions at a time on that machine. You might be able to resolve any individual prediction "quickly"; but unlike an IO-bottlenecked workload, that "quickly" doesn't involve the worker thread ever blocking + yielding the CPU to other workloads while waiting on anything; it's solid 100%-pinned CPU-cycles on that core, all the way through the prediction. There is no advantage in oversubscribing the machine with workloads; running KN predictions across N cores makes each query take (slightly more than) K times as long to run. You may as well just make each machine the smallest size it can reasonably be to run the model (as each machine then gets its own IO memory and IO "breathing room", and you avoid the price-premium of using latest-gen parts), stamp out horizontal replicas of it, and load-balance between them.

This is why so many phones and other low-power devices are shipping with "AI/ML accelerators": putting ASICs in, tuned to run specific ML-model architectures faster, can vastly lower the power budget for the device as a whole, as running (concurrent) models on the device would otherwise have to ramp up the CPU to its highest frequency and pin it at 100% to do one of these predictions.
Binance is the biggest exchange by a huge margin. It dwarfs coinbase and FTX.

They are also huge investors in crypto and any winding up will have an impact on a significant number of companies.

They control a significant portion of stablecoin, defi, and chain market too.

Their impact would be felt outside the crypto space if they ever go down.
The conviction of Martha Stewart didn't relate to any of the principal claims made against her but rather fell under the catchall "obstruction" and "lying to investigators". That she, rather than many of her much more connected and culpable contemporaries, went to prison is something of a travesty.
Disagree: SBF got into finance in the first place to earn money to donate.
This is an accurate representation of the meaning being conveyed.
I'll always be shocked that she was guilty of deceiving investors and not patients. Investors made a large financial bet while patients engaged in a routine medical procedure. To me it's obvious which group needs protection and which had a right to certain expectations.
I'm curious as to why you label yourself a "crap" employee
Cyclists are constantly being marginalized, all day, every day.
If “useful to compel” is a criteria, we can jump straight to flat-out lying and dispose with the statistics part.
Ballots can be kept track of, just like dollar bills can be. It's not rocket science.
These sorts of meta comments end up being just noise because the discussion changes over time. If you want to move the thread in a direction you think is better, be/write the change/comment you want to see in the world/thread.
Kindness was definitely in the post though -- the whole point of the closing was to be kind to those facing adverse circumstances.
I wholeheartedly agree about developing/debugging being harder. People advocating for Serverless secretly ignore this and focus on scaleability and pricing. I have worked at two places using Serverless and in those places setting up a local environment was not possible. Instead I have to deploy to a test environment to try things out. It is such a slow workflow.
Probably makes them more money. My friend that handles a very large MS account gave me the insight. When the account bought Windows it spent $5 million a year with MS. When they went to the cloud they now spend $25 million. Good deal for M$. Of course that may have been offset by other cost reductions but still a huge revenue boost to MS.
Its a game, the important bit is playable framerate. There arent any nuances when you are hitting drops to 17 fps.

>down to implementation details

Game is running 2 times slower. Nvidia favorite kind of technology. Tessellation, Gameworks, Hairworks, RTX, all run at lest 2x slower when enabled unless you buy Nvidia flagship hardware.

Did you know Nvidia physx library shipped compiled for FPU? At the time SSE2 was available for 10 years and SSE3 for 5 https://arstechnica.com/gaming/2010/07/did-nvidia-cripple-it... https://www.realworldtech.com/physx87/3/
Nvidia PR person tried claiming Physx actual computation is not a bottleneck, so they didnt bother optimizing :D If its not a bottleneck then why run it on GPU?
They did say "using the same VLF speakers in the LIVELab", suggesting it was in the same room where the concert was previously held, using the same speakers. I'd imagine that sitting alone in a room and heating three seconds of silence, 3.5s of EDM concert-volume audio, 1s of silence, and 3.5s of high volume audio would be pretty disorienting, perhaps they played it too quietly to engage the speakers?
Often, papers or terse textbooks will list a definition like the first sentence without the added detail below. I think this is great for undergraduate students or folks who'd like to refresh their memory a bit on eigenvalues, how they're derived, and what they may imply. I certainly found it helpful.
> Yes, "several" meaning single digits.

This is my point. If you can see several 500lb people a day going about your everyday errands around town, then the people on the 500lb TV freakshow are not freaks for being 500lbs, they're freaks for agreeing to be on the TV show. And how often are such massive people on TV shows that aren't specifically about 500lb people? Almost never.

If you judged America just by the TV shows, you'd think that 500lb people are very uncommon. But in reality you can see them every single day without even trying.
CZ has shut down the China branch, and was essentially banned since their crypto crackdown. He has been publicly critical of the CCP government too. The gov may not have much leverage over him.
My favorite track to test speakers for sub-bass / low frequencies:

Gwety Mernans by Aphex Twin from the album Drukqs, 2001

You could literally hold a conversation in the room while your walls and windows are shaking! Cheers :)
If you take house music and replace the drums with jungle-like off-timed rhythms but keep the same tempo, you more or less end up with electro.
Yeah, I'm sure the Fediverse doesn't use any "algorithms."
It also implicitly discounts one of the most valuable processes: verbal processing. Some people, myself included, find themselves verbalizing a problem and the tensions in every choice and monitoring the logic and emotional response present in saying it out loud.

In this way, listening and solving aren't too dissimilar. Simply listening can give the speaker an appropriate environment in which to solve their problem. A listener can play a part in helping to solve the problem, but helping foster the environment in which the problem can be solved. Don't mistake this as a silver bullet, but simply recognize that being a listener is an underappreciated role and listener vs solver isn't as dichotomous as it sounds.
>>Road damage is proportional to the square of vehicle axle weight
>No municipality in world makes drivers pay the full cost of externalities they creat

The interesting conclusion here:

1) Semis / tractor-trailer and delivery vehicles are then vastly underpaying for their externalities as their gas tax and vehicle-specific charges don't tend to be square of weight.

2) By vastly underpaying, the clients of those buying goods transported by these vehicles are vastly underpaying for these externalities.

3) Exclusive pedestrians/bicyclists, who are highly dependent on large delivery vehicles to take goods from point of manufacture to places they can access via walking/biking, are vastly underpaying for these externalities.
Somewhat/very related: https://glicol.org/

https://github.com/chaosprint/glicol

> Graph-oriented live coding language and music DSP library written in Rust
"Industry" seems like a misnomer somehow here.

I have nothing against cryptocurrency (and have a small amount myself) but the ecosystem surrounding it seems the polar opposite of "industrious" as I usually think about the word. More a lot of "get rich quick without contributing much if anything of value to society".
Similar: I like “maybe a dumb question, but tell me about X”. I am never shy about being possibly redundant or asking “dumb” questions.
I wouldn’t trust the narrator here. As the CEO, Jeremy is incentivized to exaggerate the impact. It’s yet to be seen whether Bitcoin, Ethereum or Doge will be considered securities. Neither Bitcoin or Ethereum seem to pass the Howey test [0], but who knows.

[0] https://en.m.wikipedia.org/wiki/SEC_v._W._J._Howey_Co.
I think you may have fallen into the classic white-collar trap of thinking too little of your blue-collared working peers; they're perfectly capable of getting fucked up on the job. The difference tends to be that their mistakes can have direct human morbidity and mortality associated with them, and are often followed by a drug test.
Indeed, composability is the spot-on keyword here.
Exactly. This is the kind of flexibility I was referencing in my reply.
I'd prefer we live in a world where idle complaints are not entertained. If you want advice, complain. If you do not, keep silent.
For a prototype, sure, accessibility might not be top of the list. But everything about the way this is advertised makes it sound like a production-ready product ('it's a stable, rock-solid product') and your FAQs are actively misleading people by implying that it produces accessible output.

It's also orders of magnitude harder to make an inaccessible product accessible than it is to build it in an accessible way in the first place
I feel like "I only use Facebook to keep up with family and friends" is the 21st century equivalent of "I only drink socially" - True for some people, less true for many others.
You seem to be shadowboxing a non-existent opponent. If anything, their reference to service*s* suggests that they do not expect a singular clear way.
Are these hardware cheaper than before mainly due to outsourcing, where are you making PCB? if it's from China it might not last due to the tension these days.

Another huge factor is how many kids do you have and how old are they? Age-45-or-50 might also mean that the kids are easier to handle so the parents finally can pursue something. For people that are very successful without kids, they live in a different world most of the time.
Gain function is only way to research pathogens.
And for people who don't want to read the entire book (which is good and not terribly long, probably an easy weekend read for most here) this article covers her primary thesis about how to actually change real systems:

https://donellameadows.org/archives/leverage-points-places-t...
cheers to that!
Small nitpick about C++ — tooling there is atrocious. Despite heroic efforts the language itself is a boss monster that evolves new moves every few years. Standard committee lives in a parallel universe, where writing compilers and editors is not a valid concern, yet pretending to support C source and single-pass parsing somehow is.

C++ should be something of a last resort, especially when you are given a choice.
It's a hell of a leap to go from gain of function research has ever happened at all to gain of function specifically on Ebola is a near-term serious risk. Is there any evidence that gain of function has ever been conducted on Ebola? I've never heard of it, and don't know where to look other than a search engine, and conducting a search there returns exactly two sources making that claim, one called "scamdemic" and one called "goldismoney." Neither seems like a particularly reputable source.
Unit testing sets off the footguns earlier than later. Any language that makes unit testing harder than easier is bound to have problems.

This is true with Python/Java/Go etc.

Anyone who says "If it compiles, it just usually works..." is bound for trouble, particularly on large scale projects -- golang being the obvious example of this.
I feel like this is more or less the same thing as everything before the word ‘but’ often being invalidated by the use of that word.
> It's not fair to ask people for help and then complain about their word usage when trying to help. This is a situation where solicited advice was asked for.

... yes it is. You can be forced by circumstance to ask for help from an unempathetic jerk and then still feel like they are an unempathetic jerk.

Incidentally, it is nerdy 'hacker' types who are especially guilty of putting down people when asked for help. But not all uses of the word 'just' have that effect. You can usually tell the people who are using it out of consideration versus those who are using it to demean and belittle.
I didn't know that — thanks for the info!
An almost-correct answer if you remember your elementary school science class with charges on glass and amber... Amber being elektron (ἤλεκτρον) and the root of the word electricity. If you coat the amber (or polyester) so it no longer holds a charge, by pairing its charge carriers with molecules that hide them, then you have static guard.
A tank battalion is going to have N engineering and M recon units attached (values of M and N and specific makeup of said units varies by country and service). The point of "inconveniences" like barriers is to a) make the enemy throw an engineering unit at them thereby tipping you off to a probable attack buying you time to mass force there b) just choose to attack somewhere else that is more conveniently defensible for you or where you already have more manpower.
Hashtables often treble when they reach 50% utilization. I think I'm already factoring that in. It's still 100 bytes overhead!
Apple iOS is turning into an Android, but without a headphone jack.
Serverless has its place

Several folks have written about it (Architect Elevator[0] is a good blog on these types of topics, as he routinely talks about tradeoffs and ROI to the business). High Scalability's[1] "what the internet says" posts frequently highlight serverless projects (both pro and con)

_______________

[0] https://architectelevator.com/blog

[1] most recent - http://highscalability.com/blog/2022/7/11/stuff-the-internet...