skysight-inc/HackerNews huggingface dataset:
AlphaFold knows very little about the physicochemical mechanisms governing protein folding and doesn’t give any new insights either. The way it samples conformational space is very different from Folding@home’s molecular dynamics based approach, for instance.

To describe the folding of a protein chain, a “picture” of its lowest energy conformation (which is the goal of AlphaFold—and any structural modelling tool) is not enough. We rather need a “movie” showing the steps said chain undergoes, from an unfolded polypeptide to its final, folded, native state (the “picture”).
Makeup, gross. Good riddance.

Also just in: it looks like this is fake news from a legacy media site.
Wow that’s terrible, sorry you had to go through that. If it’s not too painful, would you mind elaborating on how things progressed from taking the LSD to being in the mental hospital?
The funny part about cobol is that even if you say you know the syntax, there is site specific implementation details/features which are even MORE critical than just the language.
I don't think they were particularly successful in that, there was quite a bit of backlash about billionaires blowing millions of dollars on useless vanity projects so they can fly to space on giant space dicks: https://www.theguardian.com/science/2021/jul/20/jeff-bezos-r...
Isn't that what the promise of Docker was, you can distribute the docker image and everyone is running and building the same thing?
Speaking of desert farms: California feeds the US. https://stacker.com/stories/3183/states-biggest-agriculture-...
" That is the very reason why Soviet establishment chose not to lie"

I love the things insane tankies say.
The user I was replying to dropped this as a quote when describing what the devs were saying.

> Screw you racist, we're never going to remove it

That's creating a narrative, it was never said.

>On the contrary, saying that anyone who disagrees with you is a "bother" is offensive, especially if you flip-flop on your position and plug the change in anyways, which is what they did

Literally anytime you talk to someone and they don't want you to, that's bothering them. There's a discussion to be had if its reasonable to be bothered by the behavior, but whether or not its is bothering someone is literally defined by that person's belief.

On that note, if you find what Nutomic said offensive, I think thats a little too trigger happy on being offended.
Probably cnc machined
Our cities can be engineered to survive severe earthquakes, with tools we have right now.

We can't engineer ourselves out of an asteroid impact. Yet.
The way a survey question is phrased can dramatically affect the responses. Without references, I assume some cherry picking and loaded phrasing here.
> Their terrible worker treatment isn’t endearing in any way either

Yeah but they're Chinese workers, so people are happy to look the other way /s
Why would you ever mix them?! Even when I started programming 15 years ago it was already accepted wisdom that that was a terrible idea.
There’s only ~5 income brackets so moving “more than two” is indeed mathematically challenging for anyone in the middle.
This is pretty reasonable, and what we've been doing, though for different reasons. For example, a single chicken breast is plenty to make something like Pad Thai for a family of 4. Get creative!
They were just two random examples. As a server's connections build, it'll inevitably reach a point where it sees most/all of the network and it's no longer distinguishable.
> But, why do we need to use race as a proxy?

Because historically race was used systemically to limit opportunities for people of color. The last school to be desegregated was in 1963. Think about that.
Google is one of the most harmful entities on the entire planet. Anyone who doesn't realize that just... doesn't know enough about the topic yet. Nobody is as good at extracting profit from unethical and outright harmful behavior while simultaneously shifting the blame onto someone else for it.
That's all the media and the politicians are ever talking about: the things that separate us, things that make us different from one another. That's the way the ruling class operates in any society: they try to divide the rest of the people; they keep the lower and the middle classes fighting with each other so that they, the rich, can run off with all the fucking money.

Fairly simple thing... happens to work.

You know, anything different, that's what they're gonna talk about: race, religion, ethnic and national background, jobs, income, education, social status, sexuality, anything they can do to keep us fighting with each other so that they can keep going to the bank.

You know how I describe the economic and social classes in this country? The upper class keeps all of the money, pays none of the taxes. The middle class pays all of the taxes, does all of the work. The poor are there just to scare the shit out of the middle class... keep on showing up at those jobs.

george carlin, 1992, “jammin’ in new york”
Why? Unless he's teaching you how to write great novels, King's opinion isn't really worth anything in the grand scheme of things.
GPT3 is not deterministic though.
There are absolutely 0 apple products that offer enough incremental value over previous versions in the world where ppl actually start watching their costs
2.5 - 3.5x fps with these optimization tricks, according to Unity GDC talk.
Bet they have pretty clean deployment pipelines though
How much manual pruning/selection from the generated text do you have to do?
I prefer desktop computers because of the better ergonomics and at that point its stupid not to connect one more wire.
The internet in general is incapable of admitting that the US does some things right.

I'm thankful every day that I live in the world the US created and shaped, and not the world that was created and shaped by China (or the Soviet Union, or the British Empire)
Tumblr occasionally deletes blogs that don't have active owners. You should have gotten a series of increasingly urgent emails, but I'm sure deliverability is inconsistent.
SVGs as Elm Code
Twitter Yellow: filter opinions and viewpointa that you disagree with
Complete nonsense. You literally make your own opportunities - although not all opportunities are obvious when present and some do not reveal themselves unless other opportunities are taken first.

How do you think the "right place, right time" people get to the right place and right time? It's not an accident - it's years in the making for most people. Some never even realize they're in the right place or at the right time, and miss opportunities. That's just how it goes...

The people we're talking about do not seek opportunities, do not make themselves ready for opportunities and do not posses skills to capitalize on opportunities. This is why they sit at home complaining about life instead of studying harder and working harder or building their own opportunity. They literally expect one day something grand will fall into their lap and they'll be the next billionaire. Life doesn't work that way...
This might be the case in wealthier neighborhoods among younger families. I grew up in a very poor part of the Bay (starts with "East") and the motivation for people to thwart change was generally around property values. Many of the families that could afford to own where I grew up (many couldn't and rented, as it was a rough area) both leveraged their house for lifestyle reasons and often either relied on it as a retirement nest egg or handed it to their children as a way to transmit generational wealth. Many Bay Area seniors would be bankrupt in retirement without their house.
Can you hit up the local coworking spaces, cafes, or other local hangouts like climbing gyms, board game places, dance venues, whatever?
mining things in space is something we could concievably do in the next 100 years or so. constructing things, like for example a 3-core electrical cable? don't hold your breath.
But 80% of the money.
https://www.pewresearch.org/fact-tank/2022/04/26/u-s-public-...
That book was written by authors with a noted conservative agenda so I’m
not sure I would take them at face value, especially given the hyperbolic title.
Many of the people today who scoff at class analysis were people who clutched their pearls at Occupy Wall Street and thought it was extremism.
Same here.

Q: are there fewer buttons on the wand controllers?

Q: what is the real technical issue here that the VP of a public company publicly is telling us?
Uniquely, American Samoans are US "nationals" but not "citizens", which makes a whole lot of things very weird.

I think we should just jettison the colonial baggage and hand the islands back to actual Samoa next door, but here we are.
Irwin | Toronto, Canada | Remote | Senior Back End | Ruby on Rails, PostgreSQL | https://www.getirwin.com/

Hi, I'm Director of Engineering at Irwin. We are a rapidly growing Fintech startup, located in Toronto, Canada. We are remote-first and hire from all over North America. We have a couple of Senior Software Engineering positions open for developers who have experience with Ruby on Rails and PostgreSQL.

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Once you apply, you will be dealing directly with me, and our interview process is very quick (one initial phone call with me, then a technical interview with developers from our team).

Our Glassdoor reviews can be found here: https://www.glassdoor.ca/Reviews/Irwin-Canada-Reviews-E23019...
How about Obama effectively repealing Smith–Mundt Act, that was previously preventing domestic dissemination of state-made propaganda?

[0] https://en.wikipedia.org/wiki/Smith%E2%80%93Mundt_Act
Seems trivial then to simulate that.. still seems like a false narrative on Sony's part
Both Amazon and Apple are really into ads right now.
At least google gets that right.

I couldnt add items to my shopping list because I had too many deleted items in keep list.
I think gender will be the more interesting one. 60% of college students in the us are women. That means a 3:2 ratio of women to men. If affirmative action is disallowed, it’ll accelerate this trend. 6 points more and there’s now a 2:1 ratio. Really feels like the premise for a radically different society.
google "github bypass paywall"
Justice Department announces takedown of catalytic converter theft ring
A Simple and Convenient Synthesis of Pseudoephedrine from Meth (2012) [pdf]
Some people try to inspect code outside of a project before including it into something.

Say there is a Github repo with a crate called "totally_safe_crate", and I want to use this crate in my project, but I am not sure whether I can trust it or not. What do I do?

What I would likely do is clone the repo, then open my editor and look through the source and whatnot and make my decision.

In this case I never intend to run "cargo run" at all, but I may want to run an LSP server to help inspect the code, or I may accidentally enable LSP in the editor out of habit or something.

In this case, it would be nice if I could be certain that simply inspecting and reading code was safe, but as it stands now, in Rust, this is not the case. We can't even inspect code to make sure it's safe unless we open the source files in a "dumb" editor.

In your example you are just adding a crate to cargo.toml and firing off cargo, so of course it's not going to be useful there. Some of us may want to be more cautious than that and actually read code before putting it in our projects.
> > Sure, but there's nothing native.

> But why? strings are used by all programmers everyday

Different kinds of strings can have extremely different performance profiles.

A statically allocated string of ASCII (single byte) characters.

A dynamically allocated string of unicode (multibyte) characters where the length of allocation is not known ahead of time is very different. C requires the developer to know the differences and knows how to deal with them treat them.
Abstract: “A novel and straightforward synthesis of pseudoephidrine from
readily available N-methylamphetamine is presented. This
practical synthesis is expected to be a disruptive technology
replacing the need to find an open pharmacy.” :)
Is “mean income” the definition of success? Seems like a low bar
OK, we've squeezed the 20 to 64 in there. Thanks!
They could pass a hat around at the yearly company meetup to cover $3m. I don't think paying for it was a big consideration when they bought it.
So a future where only large businesses serving large segments of a market are able to operate with any success while small players have little to no chance in establishing themselves into small niches. And that's of course before getting into how you broke the primary method of monetization of the entire web.
At Oxide Computer Company we are using Rust at all levels of the stack except the front end of our web interfaces. From “boot up the CPU” to firmware to our root of trust to our bmc equivalent. And more, but then you’re not in embedded land anymore.

There’s other examples too. Automotive seems to be taking a large interest…
How would you know where you’d find that key?
I think this was more common many years ago, when it was difficult to make a reasonably reliable and efficient heating/cooling system, particularly the small scale.

Modern HVAC systems can be very efficient, use minimal materials, and require only electricity lines run between homes, for a considerably lower overall infrastructure cost and good efficiency compared to a district system with very extensive plumbing.
What is the biological cause for the behavior of seeking any particular opportunity?
Green tea and resveratrol reduce Alzheimer's plaques in lab tests
Im surprised by the number of people here that didn't know Cree has been making horticultural lights for years or know that there are multiple other companies making high performance horticultural lights for many years. I was building grow panels and lighting setups for cannabis years ago to get people off from using shitty blurple LEDS or shitty sodium bulbs or florescent bulbs and whatever other super inefficient garbage that people have been buying.

I find it incredibly sad so many companies are scamming people selling 20+ year old lighting tech for plant growth. Oh sure they save 20% on initial setup costs, only to pay multiple times more than that "savings" in energy costs the first year alone.
You can get free hosting at Vercel or Netlify or similar.
There's no reason to do what you want as a single file. Just write normal HTML and Javascript.

Being able to send people a URL is a lot easier than having to mail them a huge HTML file with everything embedded, even if you could theoretically do that with like data URLs and base 64 encoded images and whatnot. It's just not necessary and will make your project more complicated. And updates will be very hard to manage.

There's a whole industry built around web apps because they are easy to deliver to anyone with a browser. You don't have to reinvent the wheel here.
I worked for a company that claimed to do this. The secret was instead they locked you into their company. You had your full choice AWS, GCP or Azure... Which only worked through their web portal and infrastructure, which was entirely hosted on AWS anyway.
https://m.youtube.com/watch?v=ksb3KD6DfSI
poor dang
Rust is another example of this. Just bringing in grpc and protobuf gets about a hundred dependencies. Some of them seemingly unrelated. For a language aimed at avoiding security bugs, I find this to be an issue. But a good dependency manager and a small (or optionally absent) stdlib has lead to highly granular dependencies and bringing in giant libs for tiny bits.
https://github.com/edsu/whrss

https://whitehouse.gov/feed
Here in Texas, any student from the top 10% of their high school is guaranteed a place at the flagship University of Texas at Austin.

This is widely understood to be a form of affirmative action. Naturally, high schools in underprivileged areas - rural or urban - will produce students who are nowhere nearly as prepared as students from elite or wealthy schools. We ignore that difference as a policy matter. Top 10% is top 10%.

Maybe the Ivies will move to a similar system in the wake of the current SCOTUS case.
Yes, because you're giving them more power to disseminate their views and later suppress yours if they so choose. In this case it's a bit different, since it's a federated model, so you can just run your own node, but I'd rather not support the work of people with extremist views.
> the ++ operator only acts on integer types

no, I believe it works on pointer types and enums as well
How so? Every instance is not independent, they all communicate with each other. In practice, it's like everyone (Misskey, Pleroma, Mastodon) is on the same platform, except that some users have an address after their handle.
Can you please not fulminate or post flamebait to HN? We're trying for curious conversation here and those are two of the things that most prevent that. That's why they're against the site guidelines: https://news.ycombinator.com/newsguidelines.html

Of course this doesn't mean you're wrong—it means you need to present your view thoughtfully and in a way that appeals to curiosity. That's especially important if your view happens to be right, so it's in your interest. (I'm adding this because the field around childbirth is intense and there are such strong feelings about it—justifiably.)

We detached this subthread from https://news.ycombinator.com/item?id=33437247.
> And an excellent system involves collecting fare revenue from riders.

This is far from self-evident. There are at least two ways to fund such a system (and variants within), and most systems are funded by a combination of taxes and user-fees. Unlike roads, which are usually free at point of use, and this model should probably be applied much more often to public transport if we are to wean ourselves off driving everywhere.

> The answer is that you’re not spending it to halt X, you’re spending it to halt 10X down the road.

You need to justify this somehow to justify spending X > Y on enforcement. This is very far from self-evident, and my hunch is that these numbers are either relatively stable, or correlate with economic 'health' of the community, which is to suggest that the 'network effect' doesn't apply here as you suggest.

Your enforcers will not be (anywhere near) 100% effective either. At best, maybe you can expect to break even, but even that is probably difficult, and since 'breaking even' means significant negative impact on individuals, and has serious risk of scope creep and perception issues with the 'transit cops', it doesn't sound at all worth it.

What happens when someone gets caught dodging the fare and fined? They can't afford to pay the transit fare, and now they can't afford a fine that is, what, 20X the fare, and it just adds to their stress / debt load / collections coming after them. Meanwhile, since they can't afford it, they don't pay it, and the city doesn't actually collect any revenue from this endeavour. This is like library fines - the people who most need the system either get excluded from it or it even starts actively working against them.

Unless the system is running into capacity limits (or capacity break points), the marginal cost of freeloaders using the system is effectively zero; the trains run anyway. The ROI on paying for enforcement is almost certainly going to be terrible. It's very reactionary 'wrongdoers should be punished' thinking that doesn't actually solve anything.

Remember that governemnt services like public transit shouldn't be operated like for-profit businesess. The product of their efforts, and the way to judge them, is people transported, not dollars.
This is a beautiful post and I agree with all of it 100%. Thank you.
I know why many minorities have (/still do) faced disadvantages. I am not questioning the problem, I am questioning the solution.
Maybe you could reach out to that Senator's office. AFAIK, you cannot be sued for the testimony you give under oath after being subpoenaed.

Talk to your lawyer first, obviously.
My cousin couldn't afford to go to college because his mom made peanuts and his dad ran off. Couldn't get financial aid because he needed both parents' tax returns. Forcing kids to prove they're poor means rejecting poor kids with absentee parents.

Antisocialism is the root of so many of America's problems. Tax wealth, seize inheritance, and don't charge for higher education. Guillotines only work for the people who can afford them.
That only works if your definition of class is purely economical, and you stop looking at the 0.01%

If your definition of class is more European, it's perfectly possible to be upper class and have a down generation, economically speaking, while your network remains upper class, and your children go right up again, as they don't make the same relatively low salary choices of their parents. This is a well measured situation all over the world, and the US is not special. See the well known studies in Italy, where ancestry and class correlations are linked for over a dozen generations.

But let's say all you care about is income, and look at intergenerational income mobility. It's not as if the United State does all that well, and most of the difference is emigration of high class immigrants. The doctor that can't get a job in the US as a doctor, but whose children vastly outearn them, becoming relatively high class quite quickly. See https://www.chicagofed.org/research/mobility/intergeneration....
Benefits of white is it looks more natural for people buying/inspecting plants, think aquariums etc. Benefits of narrower band LEDs is it’s more energy efficient and cheaper, think indoor lettuce / pot farms.
He brought this mess onto himself by himself. Let us keep in mind: he wanted out but he had to stick to the mess he created himself.
System engineering is the art of specifying the general, overall characteristics and design of the thing to be produced without overlooking any detail which may later turn out to have been important.
All it takes, up to and including having someone else photograph a scene you staged and posting it on the internet.
I dunno man, gcc as a binary, make as a binary, shell as a binary, wget, up2date, dnf .. its not integrated...
No one retaliated by crashing over this. Maybe you're confused about drama with Hamlin from before this.

Most of the radio chatter was positive, and the one complainer from the field is a guy who tried and failed with same move last year.

From reverse skew to the Charger Daytona NASCAR is not new to messing with gaps in rules.
In the 90ies I used 'calling cards' to 'dial in' to Frankfurt, and then via touch tone entry of the real number to Florida. Interestingly that wasn't only ridiculously cheap, but much better quality than dialed directly via my native Telco/ISP. Also no latency, sounded almost as good as native ISDN.
Somebody here on HN said something that I think perfectly explains my relationship with The Economist: they are right a lot of the time, but they are always really late with their takes. This is a perfect example of something that people have been saying for many decades, and it would have been a good thing to remind us of five or ten years ago. Now, I read it and I'm like "well... duh."
I've found that people have wildly different definitions of "systems engineering", but this one is lovely. And also, very close to my own. ;)

https://jessimekirk.com/blog/whats_a_systems_engineer/
Yeah, at the moment, I'm reading books, papers, and articles on physics engines. I'm still evaluating my approach to the design of the Physics engine.