skysight-inc/HackerNews huggingface dataset:
This review describes investigations of specific topics that lie within the general subject of HSV1’s role in AD/dementia, published in the last couple of years. They include studies on the following: relationship of HSV1 to AD using neural stem cells; the apparent protective effects of treatment of HSV1 infection or of VZV infection with antivirals prior to the onset of dementia; the putative involvement of VZV in AD/dementia; the possible role of human herpes virus 6 (HHV6) in AD; the seemingly reduced risk of dementia after vaccination with diverse types of vaccine, and the association shown in some vaccine studies with reduced frequency of HSV1 reactivation; anti-HSV serum antibodies supporting the linkage of HSV1 in brain with AD in APOE-ε4 carriers, and the association between APOE and cognition, and association of APOE and infection with AD/dementia. The conclusions are that there is now overwhelming evidence for HSV1’s role—probably causal—in AD, when it is present in brain of APOE-ε4 carriers, and that further investigations should be made on possible prevention of the disease by vaccination, or by prolonged antiviral treatment of HSV1 infection in APOE-ε4 carriers, before disease onset.
I dearly miss my adoptive father, and his close friend, who introduced me to computers in the early 1980s, in a dreary backwater town of a backwater Middle-Eastern country, starting with a Sinclair ZX-81, soon followed by a ZX Spectrum :)

We were always behind the rest of the world in everything; to get new software or books and magazines we had to wait for someone to make a 10-12 hour trip to the nearest major city, which happened once every couple months, so we had to prepare wishlists in advance ^^

Those 80s computer mags were the best part of my childhood: Your Sinclair and specially ZZAP! because those were all I had access to when someone else was using the TV, or the computer, or just waiting for the electricity to come back on (something which that part of the world still struggles with)

I graduated to a Commodore 64 and fantasized about getting a Commodore Amiga, but by the time we could afford a new computer, the world had moved on, and I got my first "IBM PC" in 1993: a 286 with a 40 MB (megabyte) HD :)

My dad's friend, my uncle, was pretty much a genius who had taught himself electronics, repaired his own TVs etc and even built his own audio equipment and other simple devices for his friends. He tried to teach me programming in BASIC but none of it stuck with me (I try to make up for that by learning Z80 and 6502 coding these days)

The guy died relatively young, and his genius was never recognized outside our small town, but the children he influenced and instilled a love of technology in, always remember him and owe their skills to him.
I empathize deeply with you. I have been dealing with a system of "infinite configurability" for the last couple years and it's playing out the same way. The best I've been able to do is slowly codify the most problematic corners and put guard rails as many places as possible.

Sometimes I want to put my hands up in defeat and leave but there is also a satisfaction and growth from simplifying the Rube Goldberg machine.

It still sucks though.
One of Reddit's largest subs (BPT) actually requires the user to submit a picture of their forearm skin color[1] to be granted access to the full sub. If you are the wrong skin color they require a written mea culpa disowning the sins of others who may have had a similar amount of skin pigment as you. And yes, in 2022 this is still the policy.

Reddit being a home for racists like this would probably generate a ton of scrutiny if they go public.

[1] https://www.nytimes.com/2019/10/08/us/reddit-race-black-peop...
The clear signal is this article signaling from Russia to Russia. A field trip to a sub is at the very most, just a reminder that we have such subs in such places.

Why write this article? I guess it helps to cement the idea that the U.S. is aggressive and a threat independent of (not in response to) Russian actions. The narrative, I suppose is: "If the U.S./NATO do anything aggressive towards Russia, well, it's nothing to do with the 'special operation' Ukraine. Look at how aggressive they are on the nuclear front, and how defenseless Russia is! This is all just a pretext to do what they've been planning all along!"
Whoever can type a resume of that length in a typewriter with no errors I would instantly hire. Such level of attention to detail is extremely rare these days.
that's not final though, like val in Kotlin
You can also save it to your phone, you only need to scan another QR code if you want to save it on another device
The practice has some merits.

Sometimes a thread simply evolves out of a conversation.

Sometimes one comment just leads to another.

And sometimes it's helpful, useful, and/or interesting to have individual sentences or paragraphs of a thread split into their own items, so that it becomes more clear what specific parts of a discussion are especially engaging, confusing, interesting, etc. People can comment or respond to specific parts of the thread rather than the whole thing.

For writers who are accustomed to either global/overall feedback, or none at all, this can be enlightening. It's about as close to the experience of giving a live lecture or presentation as exists online, in that in a live presentation people can also respond or react to specific moments as they occur.
Good, maybe their annoying recruiters will stop sending me emails.
It seems. But it refers to the paper or wrap, not splitting between tobacco and weed, apparently.

https://en.wiktionary.org/wiki/spliff
And at any time during this process you can easily and readily lose the copy from Excel.

God its so annoying to tab back to the sheet to hit Ctrl-C again.
From what I've seen, Italian coffee consumption is nothing like American coffee consumption. They don't sip at enormous cups of drip coffee while working, but instead quickly drink small amounts of espresso as a break. It seems to me that leads both to less caffeine consumption and more actual enjoyment of the beverage.
In the specific case of Apple, your PassKey is stored in iCloud, and so can be retrieved from any Apple device you are signed into.

Without this kind of cloud sync, you need at least two devices, or you will be locked out if you lose or break one.
This 'fact' gets batted around so often and its incredibly misunderstood. That is saying that in the worst case, where everything goes wrong, the cable can last no less than X cycles, ever. Also, it's not 16.

Also, these new connectors have the exact same rating as the prior 8-pin connectors.
Do you use fingerprints to unlock your device? The page asked me to identify via fingerprints
The problem of cross-machine passwd was solved before LDAP by something called NIS, also from Sun Microsystems. NIS was called Yellow Pages originally, so it has program names like ypbind.
Foundations of Data Science (2020) [pdf]
From what I remember, your biometric data shouldn't get associated at all. Your hardware uses your biometrics to unlock the onboard enclave / vault and then the process asking can obtain or create what it needs once unlocked. If you don't have biometrics enabled it would resort to your phone password/pin.

Don't take my word for it though!
To build a better quantum computer, look into a black hole
This is funny because the other language I think of which wouldn’t be nearly as popular without an IDE, is Java. Especially older versions of Java.

Java is way too verbose to be workable if I have to write out all of the class declarations and anonymous classes and “equals/hashCode/toString” boilerplate and “ExtremelyLongClassName foo = bar.extremelyLongMethodName(…)”; and there are too many pitfalls like comparing with “==“ instead of “Object.equals” and implicit null. Except that I don’t have to write out anything or worry about any pitfalls (well, implicit null still hits me sometimes, but @NotNull and @Nullable make it much less common) in IntelliJ. IntelliJ has such powerful and seamless analysis, it does aggressive code folding on Java 7 so that you are looking at code with “var”s and lambdas. It also has built-in support for popular libraries like Spring and Lombok.

IntelliJ single-handedly turns Java from a verbose, legacy language into something I could actually recommend and start new projects on (although at that point I usually go with Kotlin). And Eclipse, NetBeans have very deep Java analysis as well. Java may have started off without expecting IDE support but now IDE support is responsible for a large part of its popularity.
My M1 Mac mini from 2020 says "Made in Malaysia" on it.

The diversification has been happening longer than many people believe.
Do all developers learn only from building? I don’t think watching tutorial is useless…….sometimes your work restrict you to know a scope of a language….and watching other videos can expand your mind
iMessage Down?
The problem is evolving the interpreter in a way that doesn't break bazillions of third party bindings -- Win32, OpenGL, Fortran for NumPy/Pandas, databases, GPUs, every C and C++ library ever, etc.

Python's C API exposes ref counting and the GIL. It's also very large

JS doesn't have that problem -- more code is written in pure JS, there are no C/C++ bindings in the browser.

There are C/C++ bindings in node.js for v8, but as far as I know they are discouraged and not used very much. The bindings are more "first party" in node.js than third party.

They have issues, but not the same ones as CPython, because the API is very different

JS VMs must be re-entrant because they're embedded in browsers. That was never the case for CPython
Seens like beetween 60's and 80's every dev in US would inevitably ending up working for us military.
> Today, I am at, or near the peak, of my physical health (180 lb, 6'2, daily swimmer)

Swimmers, in general, are optimistic and far more tolerant of misery, and you haven't accounted for that bias.
Despite that, most people in flood zones don’t have flood insurance.

> A 2020 survey conducted by the group found that 27% of all American homeowners insurance policyholders said they had flood insurance. And Wharton’s Risk Management and Decision Processes Center similarly found that, on average, 30% of homes in the highest-risk areas nationwide have flood coverage. [...] About 56% of consumers incorrectly assumed floods would be covered by their homeowners’ policies, according to a 2021 survey by the National Association of Insurance Commissioners.

https://www.nbcnews.com/news/us-news/hundreds-thousands-flor...

> President Joe Biden declared nine counties disaster areas Thursday, making residents eligible for federal aid to pay for minor home repairs, short-term housing and other emergency costs. But of the 1.8 million households in those nine counties, only 29 percent have federal flood insurance, according to an analysis of government records by POLITICO’s E&E News. That leaves 1.3 million households at ground zero without federal flood coverage.

https://www.politico.com/news/2022/10/01/hurricane-ian-will-...
Calling me sheep is not an argument, it's a projection. I'm not the one listening at shouting people on the internet.
Right, i was imprecise with that and should've said "commingling is only an option if the delivery is fulfilled by Amazon". The rest of my comment was entirely on point though.

Kinda a stretch to say it's a minority though. There wouldn't be such an issue with counterfeit articles from Amazon if it wasn't the norm
I don't know anyone who do that on whatsapp.
What do you mean by "a high interest rate environment means that all that future growth has to be discounted back to a much lower net present value"?
Fashion and art are a special case because to some extent the value of what is discussed will shift with the amount of attention given to it, since it has much to do with social signaling. The magazines boost or even determine the success or nature of what the sector becomes.
> Hire someone right away and let them quit if they want to and hire someone else. It's just business for crying out loud.

You're not hiring construction workers, you're hiring architects. It often takes more than 3 months to get used to a new codebase and understand how and why things are done the way they are.
GitHub Actions are being abused to run mining operations
> C# is VERY different from even just what things were 2 years ago

C# and TypeScript are converging (both from Anders Hjelsberg).

Small repo here showing just how similar they are syntactically: https://github.com/CharlieDigital/js-ts-csharp

I'm surprised we don't see a bigger uptick in C# usage given the growth of TypeScript and how similar the two languages are. If you know C#, it's pretty easy to pick up TypeScript and vice versa.
Cheat Codes for Life I Know at 36 That I Wish I Knew at 26
I feel very similar but have struggled to set aside enough time to find a better replacement. For work I often build one-off scripts, web scrapers/automaters, data tools, and backend web apps/APIs. While I don't disagree with your comments about the ecosystem, I find myself very dependent on it to do the aforementioned work (playwright + beautifulsoup, peewee/native sqlite3 lib, numpy + scikit, Flask/Django) and is probably the main reason I've continued using it. Does anyone have recommendations for some directions I could research? Go and/or Rust seem to be clear contenders but I'm not sure the ecosystem has equivalents or at least mature-enough equivalents for the libraries I use. Very open to learning about other languages too but simply am out of the loop. Something with a great type system and some reasonable flexibility would be amazing (eg I like that I can mix classes and functions in modules easily in Python compared to say old-school Java where everything is a class). I'm also not looking for a language that's primarily functional at this time, too much to learn right now on top of a new language, but it's on my long term to-do list.
> how hostile Guido always has been to alternative implementations.

Isn’t mypyc effectively an alternative (AOT-compiled) Python implementation? Guido doesn’t seem too hostile too it.
Amazon.nl does support iDEAL
Just to address one of your many points: "contractors don't get raises"

I heard similar at my company. But every year I write a letter requesting a raise and send it to at least two people in the company. "One of the owners..." then send the letter to more than one owner or an owner and your direct manager. That owner probably wouldn't re-iterate how cheap they are if a direct-hire is cc'ed.

In the letter, I politely explain my recent contributions, the fact I have competing interests and other opportunities but would like to keep working there. I don't make it sound like I have one foot out the door but it's implied I am standing near the door and it's up to them to keep me.

I have never failed to get a raise in over 10 years. When I shared this with a co-worker (contractor), I learned she hasn't received a raise in 4 years. Same goes for the other contractors (5+ years?). The money is there, so just ask for it. If they don't have the money for a modest raise then it's sinking ship.
My experience from around 2017: Today's employers just don't like good simple resumes for some reason. They expect you to be a graphic designer to even look at it. I had a clearly formatted, simple resume and had a 0% success rate (besides one offer for 30k which was an insult) after hundreds of applications coming out of college to places far and wide or local, until a recruiter for a consultancy company cold contacted me. People online lombasted my resume for not being fancy enough. I still think it's an example of a perfect resume personally. Doesn't matter anymore thankfully now that I have a great job I want to stay in.

Found a picture of it for reference, plus or minus minor tweaks depending on the company: https://external-preview.redd.it/Sfx4gvcEZXKXr8cxBseyyW2ycGP...

Certainly far above average chops for an entry level applicant so I don't know what every employer's problem was. Much harder world for junior developers than anyone would make you think if even I had that much trouble. I was legitimately scared I had no future outside of fast food for a while there.
Hammock Driven Development by Rich Hickey [1] is a presentation that dives into why taking a step back from the immediacy of a problem often leads to clarity.

[1] https://www.youtube.com/watch?v=f84n5oFoZBc
I tried instacart once, then never again because I felt dirty and it wasn’t that convenient.
More info:

There are a bunch of Chinese handhelds that people use for emulation, some of which can run PICO 8 games.

My Anbernic RG351V does it but I don’t think it came with the stock OS, requires some tinkering.

Anyways, there is already a small market for handheld “fantasy console” players that might respond positively to the open nature of the clockwork pi devices.
This resume has better UX than 80% of the resumes I've seen - which is particularly frustrating especially if it's a FE resume. These days I'm happy if the candidate can correctly spell the technology they claim to have been using the past N years. Most are full of bullet points with every other word bolded. If the bulleted skills list is greater than 5 lines chances are it has the same skill duplicated multiple times. I'm not sure if the candidate is fully to blame as I'm sure the recruiting companies manipulate the resume format. But ultimately the candidate is responsible for the quality of the resume.
I'd be careful about recommending Awesome dotnet, their list has some deprecated codebases like NancyFx (I'd bet others but I know that one)
How does this work in a SOA situation? Like do you have null checks + default values at every HTTP boundary for your application?
When signing up on a Windows machine with Firefox it doesn't let me use Yubikey but prompts for a Windows Hello PIN instead. Canceling the dialog doesn't go to the next available method (like it normally does) but just retries once again, after a second cancellation it just gives up. I'd say this makes this whole thing completely unusable, because under no circumstances would I ever want to use a machine-bound authenticator (unless that's the only option I physically have). I really cannot think of any reason, it won't give me any extra security and it will make things needlessly complicated in event of device loss.

To make it worse, when I'm trying to sign in, it prompts me for my Yubikey PIN, and not Windows Hello PIN. Basically, multiple token support is badly messed up.
You can always switch back with enough practice.
I’m given a prompt to either use another device or an external key. Those are the only two choices. Or am I supposed to create via email first and that’s what I’m missing?
The Pocket CHIP created this itch for me, but the keyboard on that thing made me realize how everything can be so good and just completely fall apart around one detail.

So, I'm leery about this and other things like it. I want a portable, pocketable computer on which I can hack and code away at fun things like graphics and games when I'm bored or waiting in line or whatever, but I'm becoming increasingly convinced that "small size" and "usable keyboard/UI" are mutually exclusive.

Might just give this a try, though!
The Spotify CarThing has been jailbroken
I literally got an email yesterday from Amazon recruiters with the subject line "Tired of recruiters who never give up?"
Draft, Sketch, and Prove: Guiding Formal Theorem Provers with Informal Proofs
I must be looking in the wrong places, but I don't have the feeling that Fortran on my Resume has really helped me a ton. Fortran is a fine language and of course "real programmers can write a Fortran program in any language," but it is hard to compete with the breadth of C++.
Outside of tiny niches the world is on Python 3 now, so I don't think older versions are particularly relevant when evaluating how complex Python is. For that reason old vs new style classes don't cause issues. Nor do the existence of niche implementations like Stackless, unless we want to also claim such implementations as sources of complexity for C++ or (especially) Common Lisp, at which point it's a wash.

Having trained many newly-graduated data scientists and engineers to a level of being reasonably productive in Python, my assessment is that it is simply not that difficult to get a handle on. But if I'm expected to take non-career-programmers to comparable C++ fluency, that would be a considerably longer process.

Things they'd have to worry about in C++ that they don't have to worry about in Python: memory leaks, memory debugging, complex templates, libraries written in the lowest-level way possible, move semantics, ...
Python3 yes, but Python2 will have faded away.

Perl! Oh, poor Perl.

Python 3, or its children, will be around a long time.
As will some version of /bin/sh
I would very much like to donate some cash to improving Emacs in general. It's been by far the single most powerful tool I've ever learnt and it's been a huge productivity boost.

Some of the suggested packages would be worthy recipients of donations, but I'd like to throw some cash towards improving Emacs on a more fundamental level. There have been lots of improvements recently but we could certainly do with more.

I know I can donate directly to the FSF, but I don't believe any of that would go towards Emacs development.
> Except the .NET runtime is about 5-10x faster than those runtimes.

Which is going to be irrelevant because your app performance will be mainly limited by network/database.
I did not know that Drizly was an Uber subsidiary. I wonder how much of the "disregard for authority" DNA of Uber got on them?
Flagged, because anecdotes are interesting, but they are not data.

Sometimes people share houses, time, and fluids, and one might get sick, the other not. Similarly one might get sick, then recover, and the other might die.

COVID is a topic that brings out lots of emotion, from all sides "Listen to the science", "Released from a lab", "fake news".
I think Samsung has a lot more power than you are suggesting here. Samsung is what ties together a Windows Laptop, an Android phone and a Tizen TV. As for wearOS I see your point with Google owning this compatibility layer, but it doesn’t carry much weight when there are a mere handful of devices to mix and match with. There is just not much leverage created out of spending the time and effort to make the ecosystem. How many combinations of Android TV products pair up with Android phones?
If software was so regular like construction, we could automate most of it.
Does Rust help solve overflow errors? Don't you need to explicitly used "saturated_add" or "checked_add"?
Optimizing language choice for something as fundamental as the kernel for compile speed seems very naive and short-sighted to me.

If I had a choice between 50% CVEs and 2h per compile or 5' compiles, I'd take the former in a blink.
Not really sure why they're branding it as a console when it's basically a portable Pi, and therefore far more versatile than "game console" implies. I suspect that will cause some confusion among potential customers who initially just see it as a game engine runtime.
What’s the cost of environmental impact?

It seems like we are missing some costs in our calculations.

That labor is not going to be able to keep producing stuff if their environment is wrecked. So what’s the cost of that?
Performance.

So many people say it doesn't matter. Until it does.

Python works around it by having so many libraries built in C or C++.