skysight-inc/HackerNews huggingface dataset:
I don’t know that adult tuna are at much risk from these sharks. Not only are the tuna much faster, but both species are predictors of roughly the same weight with the sharks tending to be smaller and both preferring to hunt smaller fish.

Younger or weak specimens could be, but yellowfin tuna presumably also occasionally chow down on significantly smaller sharks.
All domains come with various catches.
I don’t mean to dissuade you, because simulating biology is a truly fascinating task. That said, what you’re describing would be a monumental task, not exactly a free time side project.

Consider protein folding. This occurs millions of times per second in the thirty trillion cells in the human body. We only just now built a machine learning model that can predict some of the conformations of individual proteins.

The crazy thing is that protein folding is the easiest problem in biology. Nice clean training data, static high resolution targets. Cell biology is not that. Cells are noisy and constantly changing, and its insanely difficult to even measure what they're doing. Like every time we try to determine how many different types of cells there are, we come up with a different, larger number than before. The reason for this is that all our measurements of the number of proteins, RNA, and other chemicals in cells are bad, like looking through a distorted broken lens.

Complicating all this is that biology is is insanely coupled across both spatial and temporal scales. Consider the KRAS protein. Its one of the most commonly mutated genes in cancer. The most common mutations in KRAS amount to about a dozen atoms being out of place in the protein, due to a single base change in DNA. This nanoscale change in a single cell propagates up to tumors that interfere with bulk physiology and result in death. Or, more specifically for the brain, consider huntington’s disease. Theres a section of DNA thats repeated in a gene called huntingtin. If you have less than 36 copies of the repeat, the you're fine. More than 36 results in a brain disease that typically takes 30-50 years to even manifest.

So, all that to say that simulating this is insanely hard. Like, you’re trying to write a simulation for a system where we dont know what it’s made of or how its individual parts work. Also, we just empirically know that changing the arrangement of a few atoms can result in massive changes that lay dormant for decades before they suddenly appear.
if you havent used in 10 years how can you judge the usability objectively?
An absolutely AMAZING studio, in my backyard, that had done nothing but succeed on the basis of their culture. They respect gamers, because they ARE gamers.

They made the GBA sing.
Ok, but how are his views substantially different from those of a large fraction of the American voters?
I've been learning Go recently and it's been such a pleasure, particularly for 2D gamedev (with ebitengine.org). I don't think I've gone from reading the spec to being able to read others' programs fluently as quickly as I was able to with Go. Plus it's so fast! Compilation times had me thinking it was interpreted when I first started playing around with it.
> You should try to live in an actual low trust society (where people can't trust institutions and instead revert to their family or clan).

I live in the US but grew up in a society closer to low trust. Lots of pros and cons to both, but I think one thing you are overlooking is that there are things a family/clan provide that are not replaceable by institutions or other things.

No institution will provide the same moral support when a loved one passes away that family/clan does. No institution will blindly stand up for you, no questions asked. There are downsides to these types of societies, but there is a lot of value to these types of bonds/relationships. Less about trust, more about care. You are never emotionally isolated (even if you really want to be). You're always interconnected.
I think it is better to think about it as XDG failing to respect a world that existed long before it did. $HOME/.* namespace belongs to the user, but contents are special. It's almost like complaining about Linux enforcing the naming of certain file extended attributes.
I don't think doubling your debt translates as "strong enough", the next generation of americans will have to pay, or debt no longer matter? will it be erased magically? looks like it will be

USD overvalued, your average Joe will struggle to export their products if your "allies" can no longer afford them

Unless the goal is EURODOLLAR USD:GPB:EUR at 1:1, there is a push to massively increase salaries across Europe, looks like i was right since the beginning
I'm not going to try to predict the shape of a protein from a chain of amino acids. I'm not going to try to predict the behavior of a human cell from Schrodinger's equation.

My project's scope is more along the lines of:

1. Taking a look at Roche's list of all biochemical pathways in the human body[0].

2. Creating a 3D model of a human body, assuming that all the molecules in the body interact only in the way that the chart prescribes.

3. Create a database of symptoms and sensations in the body, and use the 3D model to determine all the possible ways that the biochemical pathways could go awry in order to create the ailment.

The way I envision it, the model is simply going after low-hanging fruit.

[0] http://biochemical-pathways.com/#/map/1
Maybe this is a hijack, but IMO current packaging tools/workflows are a big part of the problem here. Forking a Python package to give it a new name is a giant pain, and if you don't rename it and only release it to a private pypi, you're inviting angst and confusion from your internal users. The only alternative is to put your git url and branch directly in a requirements.txt file, which is not remotely scalable.

These kinds of issues exist across npm, homebrew, apt, etc as far as I'm aware.

In contrast, Nix overrides allow patching in fixes at varying degrees of locality, making it trivially easy to maintain a long term fork or just apply unmerged fixes in the short term.
Be careful, and use Tor if possible. Best of luck, friend. I’m sorry you and your country are going through this.
When I first heard about this i was like “oh, $1.7M? Kinda high for a small building with men/women bathrooms, but the sinks and toilets aren’t cheap so not too bad”

I was picturing a small bathroom with a couple urinals, and toilets and a row of sinks on each side.

Then I saw it was a single bathroom - one room with one sink and toilet.

Jeeze
Nope, I'm still blaming the bomber for the bomb.
Let's not pretend that Apple is the only company that people buy from to signal an in-group status.

I believe people also buy old thinkpads, dumb phones, android phones, and use Linux (arch btw) to signal to fellow nerds on the internet that they are not sheep and are more tech literate than the average person.
Hidden Risks of Counting 9s
> (And would you please consider the possibility that I might not be a complete idiot?)

I do not believe you're an idiot. As a matter of fact, I think you're probably a quite intelligent individual that knows a lot about many topics. Looking at your resume, I do get a strong sense that you're a much better engineer that I ever will be, for example.

I do however think that, when it comes to this topic, you're out of your depth, since you don't seem to be aware of concepts and ideas that are taught in a very introductory course on mathematical logic.

I don't even think you have digested many of the points I've made in my last post - or in previous ones. It seems like you're refusing to engage, opting instead for picking individual sentences apart as if they were devoid of context.

I encourage you to take some time to actually study Gödel's theorems, with all their nuances and the proper historical, mathematical and logical context. The books by Peter Smith seem like a good start: https://www.logicmatters.net/igt/ - I have only read the long one (which I've linked to previously above), but I suppose the short one should be good too.

(And maybe consider that I'm not quite dumb, either. And that mathematical logic is a topic I know a thing or two about.)
iOS VPN apps have another flaw: excluding many Apple apps
Discussed at the time:

Dotfile madness - https://news.ycombinator.com/item?id=19063727 - Feb 2019 (514 comments)
These guys are talking business. Some weeks ago I vented in Twitter about problems building an example project for ESP32 (in Portuguese), someone from Espressif side was diligent enough to translate it and answer with hints (in the end, I had messed up during toolchain installation, thanks there is espup now).
what other "alternatives" are you speaking of on Linux?
Related threads - two different homecomings:

Coming Home to Vim - https://news.ycombinator.com/item?id=4218575 - July 2012 (118 comments)

Coming Home to Vim - https://news.ycombinator.com/item?id=1710702 - Sept 2010 (121 comments)

Coming home to Vim - https://news.ycombinator.com/item?id=1619544 - Aug 2010 (34 comments)

* Coming home to Vim* - https://news.ycombinator.com/item?id=329525 - Oct 2008 (12 comments)
absolutely.

if you need a single simple example nearly any cloth-composite is commonly sold in yard lengths.
Airlines and shipping contribute about 2% and 3% of the total emissions. There is no easy way to convert them from liquid hydrocarbon fuels to something else. But it's only 5% of the emissions. I don't think there's a climate scientist out there who will tell you that if we cut net emissions by 100% by 2050 we are fine, but if only cut by 95% we are doomed.

In any case, if we use natural gas power plants only for smoothing out the peak demand, then their emissions will be much less than the current 12%. Maybe 4 or 5%. Enough room for airlines and shipping.

As for steel and cement, we need to switch them to new technologies that makes them not emit CO2, such as [1], or emit much less, such as [2]. The thing is, once electricity is cheap (because solar and wind are cheap), hydrogen will be cheap, and switching steel production from using coke to hydrogen will be not only environmentally responsible, but also economically optimal. The same for fertilizers and plastics. Cement will be a bit trickier to get to fully carbon neutral, but we'll be able to easily cut emissions in half.

All in all, there are no real blockers to get to net zero. We only need to keep the pace with solar and wind, and there are no signs that we won't be able to.

[1] https://www.ssab.com/en/fossil-free-steel

[2] https://www.cemexusa.com/vertua
The iPhone 12 is smaller than the iPhone 11. Does anybody think that it is worse for that reason?

If you buy a Ford Lightning instead of a gasoline truck and fuel it with solar power, you might use 50 tons or so less gasoline. Is that worse?

We're a community mostly built on software. A new game may provide massive entertainment on a very minimal footprint.

Sure the population cannot grow indefinitely, but it is predicted to stabilize soon.

The economy can grow indefinitely. Dollars are just bits in a computer, and so is a large fraction of our economy.
> But why look elsewhere?

I don't know what I don't know, so that's why I ask. My JetBrains IDE does so much out of the box, I figure people give up all these features for a reason. Beyond vanity and too much free time, of course.
Thankfully it’s an important enough question that some people have already done some work for us. The IMF put out a report last year about this very subject. Here’s a relevant snippet from the summary:

> Globally, fossil fuel subsidies were $5.9 trillion in 2020 or about 6.8 percent of GDP, and are expected to rise to 7.4 percent of GDP in 2025. Just 8 percent of the 2020 subsidy reflects undercharging for supply costs (explicit subsidies) and 92 percent for undercharging for environmental costs and foregone consumption taxes (implicit subsidies).

Here’s the full report: https://www.imf.org/en/Publications/WP/Issues/2021/09/23/Sti...
Meh I prefer Cloudfront
>Screen. We are still some years away from 120Hz, 260PPI, High HDR, Ultra Thin, Energy efficient Display. Something like Nano-Rod OLED

Asus ZenBook Pro 14 Duo OLED is close. It has a 120Hz 16:10 2.8K (2880 x 1800) screen. By my calculations thats 234PPI. It's not cheap though.

https://www.asus.com/Laptops/For-Creators/Zenbook/Zenbook-Pr...
Its not just the internet. The economy also plays a role.
I feel this is disrespectful. He just cannot write CEO without asking me first. This shows a lack of respect

Maybe that’s not ego, but it will do until ego shows up.

There’s nothing wrong with ego motivating a course of action.

The problem is not recognizing that’s what is motivating the course of action.

YMMV.
"Putnam’s trends can be assessed more contemporaneously through a simple metric: screen time, a proxy for time spent not doing community activities in person."

No it is not. There is no reason to believe that screen time is displacing social time. It could well be displacing reading novels or watching TV.

I do a lot of socialising. I make an effort. I see other people around me doing the same thing.

Here I am at a screen. I cannot remember the last novel I read from start to finish.
> Zero effort towards backward-compatibility or longevity, just force users to buy new hardware constantly.

Is that why you can install iOS 16 (the most recent version) on an iPhone 8 from 2017?
I don't know how you can look at a graph of how many teenagers work, drive, and go out that suddenly declines after 2008 and not mention the major economic recession at the time. While I agree that there are technological changes and purely social changes that have happened, I think there's more to the economic causes of this issue that aren't usually examined by this type of commentator.
They're pretty confident all their "loyal customers" will just immediately take everything they sell as fact and amplify it (I'm pretty sure when they launch their ad platform it will be "the most private ad platform in the world" and fanboys will lap it up).

We got a glimpse into their confidence in this regard when they were getting ready to launch the local scanner (CSAM supposedly was the first application, but it's pretty obvious they were just introducing a way for governments and other entities to scan local content on users' devices for whatever they'd consider "wrong" at some time); they were really taken aback by community outcry and really took the "you're holding it wrong" snarky commentary to the next level for a while.
What do we make of online communities (i.e. gamers), sports & recreation (parents sit down with other parents to chat), startups who's cluture is team/family like (easily replaces religion), etc...

Maybe the definition of individualism should evolve a little.
I think the real culprit here are operating systems and file systems, not programmers (of end-user applications). File systems were designed during an era where semantic meaning was just not important; all file systems cared about (and still care about) are directories and files. The whole paradigm should've been abandoned long ago for something much cleaner.
Yes, and file_size != space_consumed is pretty much the main point of using ZFS!
As a very casual coder who wants 'in' to more coding, I really enjoy the gamification. I wish the mobile app had more of it, really has helped me progress and feel like I'm accomplishing something. I know they're just green dots but really helps me stay on track and keep practicing.
A Coming-Out Party for Generative A.I
The criteria for determining a recession has historically been "Negative Gross Domestic Product (GDP) for two consecutive quarters", which we have had. The current administration seems to redefine the meaning with a new word salad definition, indicating the original definition is invalid for the current economic environment.
The OP asked a simple question. I don't understand how you got the idea that they want everybody else in their team to join them. I guess folks get triggered at the very mention of RTO these days.
I used wp2static to archive a WordPress site recently, and I am disappointed with the performance.

The same website without Cloudflare CDN and just using a simple caching plugin is much faster than the exported version by wp2static hosted on Cloudflare pages.

It has fallen from 99 to 78 in the mobile page speed test.

I tried creating a copy of the website using wget, it was faster but i faced issues with missing files and posts on the main page using temporary query links and not the permanent links.

So I went through the Hassle of compiling wp2static and just eating the performance loss instead.
After dealing with depression myself, I dove deeply into this world, and actually ended up founding a ketamine and esketamine treatment startup in the Boston area (lumin.health). We've seen pretty amazing results with patients who have otherwise failed antidepressants and/or ECT and TMS (Transcranial Magnetic Stimulation). The reality is that ketamine/esketamine are much more accessible from a patient perspective, and while considered "new" by many in the medical community, offer faster results and carry less stigma for patients than ECT in particular. If ketamine/esketamine don't work, patients typically know within 2-3 sessions, and can walk away with no long term side effects. With ECT, patients generally have to complete a whole course before they see effect, and then are stuck with some of the potential mid/long-term side effects.

The space is also at the precipice of a whole new class of psychedelics coming online - MDMA, psilocybin, and more are all 1-5 years out (working through FDA drug trials), and hold promise of both faster results (versus 6-8 months of trialing traditional antidepressants) and fewer downside risks (versus weight gain, sex drive, etc. issues with antidepressants and memory loss, headaches, etc. with ECT and TMS).

Bottom line, if you're suffering and considering those treatments, I highly recommend finding a local center and at least learning more about options available to you.

Edit: If anyone wants to talk, advice, etc., email is in my profile.
It is a hack, but given the complexity and non-timeliness of what's going on behind the scenes, and the lack of control that the user has, perhaps a good hack is the right solution.

My choice would be a cron job to run every few hours (or every day) that calculates space required and deletes logs files to that size. As long as the desired free space leaves an adequate margin, this would be robust and work in the presence of compressed files, snapshots, etc.

"Sleep 10" should be fine, but it's also a hack, and the author would need to consider how long it takes for cleared space to become available on a heavily loaded system. I would expect that under severe load, the clear-up lag could be very long.
Many thanks, that is really satisfying to watch!

The slide into the first folding motion is magical and I'm glad they just go ahead and repeat it in the video because it deserves many viewings.
No, quite the opposite. The general consensus is that it’s underutilized.
Those are also the symptoms of depression.
Please stop posting flamewar comments to HN. It's not what this site is for, and it destroys what it is for, and you've unfortunately been doing it repeatedly (e.g. https://news.ycombinator.com/item?id=33253658 - swipes like that are totally not ok).

If you'd please review the site guidelines and start following them, we'd appreciate it. Note this one: "Comments should get more thoughtful and substantive, not less, as a topic gets more divisive."

https://news.ycombinator.com/newsguidelines.html
Lessons on Leadership: Michael Abrashoff on Turning the Worst Ship in the Navy
That's called "writing in the vernacular."

Works pretty well, but tends to draw sneers from purists.

Meh. I don't particularly care. People tell me they enjoy reading my stuff. I enjoy writing it.
I keep saying this, but I wonder if we’re just repeating the cycle of the 60’s.

Post-WW2 was the height of urban cores in the US. The 60’s social unrest and a slide into urban decay led to population declines that lasted until the 90’s. People fled to the suburbs for cheaper housing, better schools and more safety.

San Francisco lost 20% of its population between 1950 and 1980.

Considering the problems SF is facing I wonder if we’re entering another multi-decade cycle of people leaving urban cores for the suburbs.
I asked them why. They said it's possible to say anything in Japanese, but English has the brevity for some topics.
Exactly, it does always irk me when people call it an existential threat to humanity. That's not to say it isn't a huge problem. But it won't wipe us out. Some areas will also become more habitable (eg Siberia)

The mass migration of people across borders as a result of climate change might cause wars that are such a threat though. But still I don't consider climate change itself as such.
Exactly this. A couple of centuries from now, people will laugh about that time people thought that the population will collapse.

Most likely, there is an enormous selection pressure right now for any genes that predispose people (and in particular women) to want to have (many) kids. If those genes are as common as I believe, they should be dominant within about 10 generations (counting from approximately 1970).
Ask HN: Is it possible to setup a VPN server on iOS?
I've searched the internet and found no clue as to whether this is possible on iOS. I know Android supports that (at least with root access), but I haven't seen any evidence that it's doable on iOS. Running a personal VPN server on iOS could help friends in other countries who suffer from super restricted internet access.
I don't know. Competition (be it to accomplish the best career, the best body, the best public persona) seems to be at an all time high. That suggests that we don't have any narrative that binds us and promote some type of cooperation. I could be wrong, but I don't think previous generations dealt with this level of individualism.
When I saw this word I first thought of "ashi-ato" (footprint). I think the word was probably made to evoke this meaning.
Running a business means sometimes swallowing your pride.

When a company is just a CEO and a CTO, someone in the c-suite has to take the garbage to the dumpster.

I don’t have a side, but one of them is working for free on a company they don’t own…because if they did own some of it, the titles would be settled on the corporate documents.
I work in mobile advertising, and Apple Search has become a behemoth that is hard for companies small and large to grapple with. I have sat in on meetings from small to large that go the same way:

We spend a lot on Apple Ads, it's ROI is terrible, but we think our ranking is helped by our Apple Ad spending. We probably can't cut that.

Do you want to try removing ASA spend for 2 weeks?

No, probably too dangerous.
Please don't break the site guidelines yourself, regardless of how bad another comment was or you feel it was. It only makes things worse.

https://news.ycombinator.com/newsguidelines.html
I go with the one offering the best WLB, pay and cool coworkers. Most of the times, you can take up interesting initiatives at even seemingly boring places.
Severe depression has objective symptoms: severe sleep disturbances, psychotic like symptoms.
what does "but contents are special" mean?
On the contrary, that's exactly what it's supposed to be.
Microsoft have made choices for vscode. Maybe even good ones?

What %ge of languages supported by vim are actually supported by microsoft - or "the microsoft community?"
I kept people for decades, and they didn't actually make that much, compared to others in similar positions.

When they finally wound up our department, the person with the least tenure had over ten years.

Good managers are worth their weight in gold.