skysight-inc/HackerNews huggingface dataset:
My Dad is currently battling a GBM. Do you have any advice for a web dev who wants to get his toe in the door of understanding the computational biology of gliomas?

I don't expect I'll be able to do much, but all of the treatments we've undertaken so far seem very dated (not able to resect, one round of radiation, temodar+avastin for the last year, just switched to CCNU+avastin). I'd love to know where the state of the art is at and know how to nudge/prompt his oncologists to be looking at it through that lens.

My email is in my profile, feel free to reach out privately.
“But it’s symbolic” is literally the cope of our generation.

It means practically nothing and we must demand more than symbolism.
> Could it be because he used to be involved with war on drugs?

That's true of pretty much every politician who's been in office for more than, say, fifteen years.

Save a few libertarians here and there.
People praise AppleTV for not having ads, but the app search there has the same promoted ad protection racket stuff.
6 500, according to https://news.ycombinator.com/item?id=33113859

In 2017, there were 650 000 marijuana arrests across the states, up from the year before.

https://wayofleaf.com/blog/weed-arrests-by-state
When the conflict is over (and it will be someday), Tesla and his other companies will be in doing business as fast as they can in Russia. In the meantime, Musk has already signaled with this tweet he's going CPAC-style Republican this election (cf [https://www.msnbc.com/the-reidout/reidout-blog/cpac-russia-u...] ) but as a citizen he can vote and tweet how he wants.
Interestingly, he specifically excludes illegal immigrants who are not US citizens from the pardon, as well as (implicitly) people who used to be lawful permanent residents but no longer are (perhaps because their visa got revoked after being arrested for possessing marijuana), as well as former US citizens (if there are any who have been charged with this "crime") and people who were never residents in the US at all (perhaps they got arrested when they changed flights at a US airport). So this is a step in the right direction, but not nearly far enough. I wonder why he went to the trouble of making all those exclusions.
While the number of people who will be materially affected by this is in the four digits, this does technically apply to every one of the millions of people who have broken this federal law by possessing marijuana.

One need not have been charged to receive a pardon.
Use meshtastic and an ESP32 wired to the detector.
> What you describe sounds more to me like the ""10X engineer""

I think 10X engineer is supposed to imply the average engineer - maybe at the person's level?

We all know there are plenty of engineers who do negative work, and plenty who do almost nothing.

So depending on how you think of it - it might not be that impressive.
The next Apollo 13 will probably be a software problem , doesn't hurt if they can read up about it
Tangent - I’ve noticed a lot more comments like this using the “^0” syntax for citations vs the traditional “[0]” one I’ve become accustomed to seeing on HN. Is there a real shift happening here and, if so, why?
> Nobody owns anything with crypto. When you give your crypto to Coinbase

Don't do that if you want to actually own your coins.
That or Fitbit get rebranded as Google Watch and now you have Pixel Watch and Google Watch.

Then they merge the two into "Watch" the new alphabet company.

Not like they didn't do that before with their chat apps.
Search outside the box: How we're making Search more natural and intuitive
I am working for a for-profit company - I have done so for pretty much all my life, including companies that either rely on, or are directly involved in advertising.

However, I don’t try to justify it in any way (even though my current client is actually completely independent of ads). I know and agree that my contributions to that field are bad for society and try to do better whenever possible, including fighting back when my contractual obligations allow me to (and avoiding contracts that would prevent me to do so).

So not really a complete “dig” to the parent comment, but rather that we might have done wrong but we should strive to do better instead of trying to justify it.
My wife and I were plenty polite, like I said many of our interactions with everyday people were fine. It was some of the workers in restaurants and hotels that were rude. There was also the pickpocket at the train station impersonating a station worker (thankfully we ignored them and the attendant in the booth told them to go away).

It’s OK though. It’s your city. We’re happy to visit elsewhere and I’m sure you’re happy we’re not there, silly Americans that we are.
They have these on Quantbase already
I think the joke is that the pardon is "even if not charged" so if you ever had weed in your possession and could have been charged, you've now received a presidential pardon (even if the feds never even knew of you).
I have one thing to say about this: “Online survey”
https://library.kiwix.org/?lang=eng&category=stack_exchange
Reducing water-hogging crops is the most impactful option (agriculture uses more than 80% of CA's non-environmental water use and agricultural water waste is more than 99% of CA's water waste), but would require state (or very likely, federal) legislation. With the current political climate, and the likely outcome of the 2022 election, this option is the least likely to happen.

Desalinization is not a magic bullet. Plants are expensive to build and to operate, even taking into account the use of passive renewables to provide most or all of the energy. There are currently 11 desalinization plants in CA (mostly in SoCal), the largest of which (in Carslbad, the largest such plant in the U.S.) can only provide enough water for 300,000 people a year. That is 30% of San Diego's water needs. CA's population is approximately 39 million. To scale up to the the entire state, we would need more than 120 additional plants just to address residential water use, for a cost of at least $120 billion (not taking into account inflation since the Carlsbad plant was completed).

Reducing grass yards has been part of the playbook for several decades now. At this point, reducing grass yards amongst everyone except the superrich would have minimal impact because the rest of us have already heavily cut back.

Gutter water flows to reclamation plants in most areas, but during storms flows directly to the ocean because the plants don't have the ability to handle the surge in flows. In SoCal, many water districts have begun using permeable asphalt to (re)pave streets so that rain water can absorb into the ground and recharge underground aquifers. A number of spreading pools and spreading grounds have also been built along storm channels, to provide areas where excess rainwater can collect and slowly absorb into the ground.
Amazon Abandons Autonomous Home-Delivery Robot in Latest Cut
Check out fly.io as well. They've been adding some SQLite stuff. They also have the added benefit that you can run just about any docker image, not just functions.
There is also the "positive" version of the politician. They have enough technical credibility, social skills, relationships with senior management, to remove organizational log-jams. Other companies might hire a consultant to come and tell them what they already know they need to do (but can't organizationally agree to do) - but with this archetype, you can call them in and they will cut out the bullshit, somehow without upsetting everyone.
If the length of our work week followed productivity, the workweek would be at 13 hours today. Your claim is completely and utterly baseless.
"Hiring well" or hiring "the best" isn't a panacea. People change. Before I had kids, I was working hard, working late nights, and some of my work was all-consuming. After, I've definitely had periods where my main focus was on showing up to meetings and making sure I got at least pretty okay on my performance reviews, while actually focusing on, y'know, not work. If the company doesn't punish people for becoming half as productive, a lot of the folks are going to become half as productive, even if they were "the best" at some point. Especially true when morale at a company drops. Canceling projects, being assigned to boring projects (the next year will focus on Sarbanes Oxley compliance, guys!), having your company or work dragged through the news, it adds up, and people get detached.
I knew what you meant. No.
Google Chrome is the most vulnerable browser in 2022
Probably. But I don't think the public really wants their voting systems to be highly vulnerable to strategic voting. That does just give elites an edge and ends up with less equitable representation.

(strategies exist for ALL voting systems. But not all strategies are equally as bad)
Now I think of it...

On the Master I could fairly easily extend the TPA up into the sideways RAM area, adding another 16kB, for a total of probably about 45kB. The difficulty is that filesystems in Acorn's MOS can't access sideways RAM directly, as that's where the filesystem module itself lives, so all I/O would have to be done by copying the data to low memory, calling MOS, then switching the sideways RAM back in again afterwards. There may also be subtleties in catching interrupts and things which might try to change sideways RAM pages. But it should totally work.

For the _really_ advanced version, it could run bare metal and reuse the OS workspace at 0xc000 all the way up to 0xe000. But that would lost all MOS services, so would have to reimplement things like screen redrawing and floppy disk handling.
So most of the experts in the field think that a change in teaching methods is the optimal strategy? Maybe there's a good reason for that.
It’s supposedly going to be fixed next year.

It took ages to reach an agreement with Apple which was offering extortionate rates for allowing their customers to use the NFC chip in their phones in a classic Apple move.
The term may well be as old as the tech industry, but I have somehow spent all 30-odd years of my career in said industry without hearing it discussed, until somewhat recently. I wonder what has changed.

I don't think of the tech industry I have been working in as being related to defense much at all - I trace my computing roots back to the home computer era of the '80s. Perhaps there have been parallel streams which are now mixing.

On the other hand I have never cared about titles, so perhaps it's been there all along and I just didn't notice.
It's worth noting that this class was admitting with NYUs test optional admissions. (No SAT during COVID)
That's how it was (and things were) when I was doing organic chemistry.

To answer your last question I could suggest some answers but they'd only be inflammatory. Here, the real problem is that it's not that my answers would be inflammatory but why they'd be considered such (as opposed to being just options or ideas, whether right or wrong, in a much wider rational debate).

The real issue is that illogical, unfounded and ill-informed opinion has stifled rational debate, it having the loudest voice—and that nowadays there's no longer any moderating mechanism that's able to pull it back into line.
Optimizing utility-scale battery storage dispatch
Disclaimer: I'm the author.

I was torn whether to share my own post, but I figured the HN crowd might include a few others who will also really geek out about this topic and appreciate it. It's mathematical optimization and forecasting used to guide giant batteries hooked up to the electrical grid, after all.

There is some accompanying code I got to share publicly, too, if you want to run this yourself [1]. While I'm at it, I'll also mention some papers for anyone who wants a true deep dive [2, 3].

[1] https://gist.github.com/lukemerrick/4e1f9921a19ec97f7b949909...

[2] Linear Programming for battery optimization -- https://www.osti.gov/servlets/purl/1244909

[3] Mixed-Integer Linear Programming for battery optimization [PDF] -- https://www.sandia.gov/ess-ssl/wp-content/uploads/2018/08/20...
Going Manic with a FitBit (2018)
Aloha all, I wrote this. It turns out:

* Bipolar disorder is not a thing. It's bipolar potential. I was never crazy. The world is. My math was always right. I just didn't have the resources to nudge the world in a positive direction.

* I have the resources now (skills, network, reputation, capital, et cetera), to nudge the world.

#BuildPublicDomain #LiberateIdeas
Sure. But it wasn't that long ago that the way you acted on elections coming up would be to adopt a "tough on drugs" posture.
Most of the blue states are legal or decriminalized at this point.

What's odd is that there hasn't been a push for clemency/pardons when legalization happens.

I don't care about marijuana, it's never been very interesting to me, but it's absurd the amount of human capital that's gone into stopping it and sigmatizing its use in this country.
It can prevent people from running or working for legal marijuana businesses in states where it is legal, meaning a history of uneven enforcement continues to affect the legal marijuana industry.

https://www.buzzfeednews.com/article/amandachicagolewis/amer...

I think Oregon either has made changes to address this or is close to doing so. This helps at the federal level.
Salary is always going to be confused world. People can often earn more as a graduate than a senior by moving to another company or country. Within an org it is hard to measure everyone's true contribution. People's salaries may reflect the job market when they joined. So someone who joined recently gets paid more for a more junior position than someone who has been at the company for years. The company needs to keep salaries secret to avoid people getting annoyed at this! Companies are now also completing for staff not only with other companies, but with investors! If someone is capable, they could go off and start their own thing too. They are also competing with FU money that people have built up. The desire to control this with titles and bands makes me laugh. Obviously big companies need to do this though.
He can subpoena records if he files a lawsuit, convinces a judge that the lawsuit shouldn't be immediately dismissed and survives arguments by opposing counsel that the records should be protected from the discovery process. I.e., not "incredibly easy", as you say. Also, ISPs usually claim in response to subpoenas that they do not retain the bodies of emails and other "contents" of communications I gather.

Also, Hans (initially) didn't want chess.com to be able to publish the communications, so he might've avoided using gmail in favor of some method that is guaranteed not to leave a verifiable record.
When Madison Cawthorne outed his peers recently as doing drugs, the problem was his outing, not the drugs. Let's be real, as long as the productive citizens remain productive, their drug use by and large really isn't a problem.
> without hearing it discussed, until somewhat recently

Maybe you’re now reaching that level yourself so now interacting with those people?

Like saying ‘how come nobody’s ever discussed prostrate exams until I got to my 40s’.

> I don't think of the tech industry I have been working in as being related to defense much at all

Microprocessors come from defence, as does Silicon Valley.
Binance Chain halted over 2M BNB hack
Not just the plant, in the case of fossil fuels' physical environmental impact.

The wells, refining plant, and pipelines for gas, and the mines, railways, and ash disposal pits for coal. And the river intakes, detention ponds and so on needed for steam and cooling water.
Poor Workplace, always forgotten. https://www.workplace.com/
You need a browser and a file. In your example you need a server to make the file and and a browser.
> Sure, the edges are fuzzy

Handwave of the century
I am guessing most/a lot of us have seen similar situations (unfortunately).
(Sometimes, though situations like that are unavoidable -- given that demos can become product overnight or a deadline is unattainable no matter what you shave off. If I had a nickel for each time I had seen any of the above happen...)
You doing okay there, pal? Reading your recent submissions (and twitfeed), it looks like you might be going through a bit of a mental health crisis. Do you have anyone you can call and touch grass with?
I can fully want someone to not see jail time and still not want them as an employee; I believe some companies even discriminate against smokers.
CMD/CTRL+f'd "access(ibility)", appreciate you making that a priority for this library! Can you eventually document how it's accessible? Would love to see that in the future.
Never trust the lawnmower to not mow your budget.
> When I was a kid, I could just make a website and throw FTP it to some server, and blammoo, my site was online.

You can still do that.
* pedaled
The comment doesn't appear flagged. That said I can't find any source to back up the man being Egyptian, much less Muslim.
> I don't really see many crypto people arguing that code should supersede law.

Evading tax laws or conducting illicit transactions is a core appeal of crypto, and obfuscating identifiers in crypto to achieve those ends is what crypto tumblers are all about.

> I'm no expert but I understand that undo-ing transactions is pretty trivial if you use multi-sig.

Per [1] multi-sig only lets you require multiple signatures to create a transaction, reducing the chance you do something stupid, so sort of like a physical check that requires multiple physical signatures. Multi sig doesn't let you (or the other signers) reverse the transaction once it is complete.

For that, you must contact the recipient and convince them to return the crypto, hopefully by asking them nicely.

https://www.coindesk.com/tech/2020/11/10/multisignature-wall...
Sure, it has use cases, but the fact is that something like a phone, or a tablet, or a TV can be used and not used within a fraction of a second as required. Putting on a headset is like going to a movie theater -- it is fine for occasions but it isn't something I can see people wanting to do regularly.
Finishing (i.e. shipping) stuff is a pain.

At some point, we reach the part where the fun stuff is done. We've learned pretty much everything we can, from the exercise, and it's "90%" done.

That last 10%, however, is a bear. Many, many folks never bother with it.

In a lot of cases, that's fine. The main purpose was learning, and there's really not enough "market pull" to justify finishing the project.

If there is a requirement to see it through to completion (like, say, a contract, with your signature on it), then we need to complete that last 10%, even if it's boring.

There's a joke: "90% of the project is completed in 10% of the time. 10% of the project is completed in 90% of the time." (there are many variants, thereof).

Ever notice how, when a new building is going up, it appears to be "complete," in an astonishingly short time? Then, it's twice as long, before the doors open?

That's because making the exterior and structure is straightforward, and can be done by just about anyone. Framing, windows, doors, roofing, masonry, etc., are skills, but not extremely specialized.

The interior stuff, though, requires a lot of skill. You can't just bring in some half-trained hammer monkey. You need the experienced finish carpenters, and the expensive painters, etc. These folks are harder to schedule, and won't rush the job. Their work is what people will see, up close, every day, so it needs a lot of polish, and has to be robust.

Same with any product.

I'm writing an SDK, right now. It was probably 90% complete, last week, but I wrote a pretty beefy test harness for it, and I am now implementing a whole bunch of "live server" unit tests. I am finding bugs in my implementation (I always do), and I'm fixing them, as I go along. I'm also encountering the "little things," that I forgot to implement.

Once I have the unit tests all humming along to my satisfaction (I tend to write unit tests after the fact, for SDKs. I write about that here[0]), I'll flesh out the documentation.

Only then, when I can release the project as a standalone package, will I return to the main app, that is my initial consumer of the SDK, and I'll need to integrate it; replacing an older SDK (that I also wrote).

Lot of boring stuff, but it means that I don't have to worry about this very critical (and dicey) communication infrastructure, when working on the main app.

[0] https://littlegreenviper.com/blah-blah-blah/testing-harness-...
What you say is technically true but you're forgetting decay heat. The fission chain reaction stops if you remove the moderator in any sane LWR design, but the fission products in the fuel will continue to generate a very large amount of heat for quite a while. This is exactly what happened at Fukushima and TMI.

https://en.wikipedia.org/wiki/Decay_heat#Power_reactors_in_s...

Some reactor designs can dissipate this decay heat with passive circulation, while most require active pumps to circulate for a while after shutdown. But a total loss of coolant is probably going to result in fuel melt to some extent.
Do we know for a fact the breakdown of 2nd choices on ballots where Palin was the first choice? If not, you are only speculating.

It seems possible that Palin lost due to voters incorrectly expressing their preferences by not putting a 2nd choice. If that is a routine thing, then it is indeed a problem with ranked choice voting in the real world, but it is NOT a structural flaw as you are claiming.
What you're seeing: a Meta headset tethered to a laptop over WiFi running Immersed.

What you're not seeing: a standalone VR headset running a VR Desktop OS natively with bleeding edge pixel density (i.e., like the Simula One).

We understand that Meta has some cool tools in its app store which can be used to get a feel for VR computing. But analogously, you could also purchase word processors for early gaming consoles too: https://en.wikipedia.org/wiki/AtariWriter

Our view is that dedicated VR computing devices are what the market actually needs.
I think the idea of "everything is about half its life" is to account for survivorship bias in longevity. The only units that make it to the 95th percentile lifetimes clearly got luckier with parts and can reasonably be expected to last longer.
in tech, we don't really have 40hr/wk. It's more like 80hr/wk. And work on weekends. If you have a position that requires 40hrs/wk or less and no work on weekends whatsoever, consider yourself lucky. I hear stories about colleagues being overworked on continuous basis.
Kiwix can do that also. You needs to specify the ZIM file and it works:

https://wiki.kiwix.org/wiki/Content_in_all_languages

Why I know that? I wanted to travel as system administrator in some antartica base with a whole copy of stackoverflow with me.
Calling first dibs on "sketchy bum colony" as a band name.
Does everyone here just suffer from exceptionally shitty IT departments? I've used Citrix for years and not experienced any of the chronic issues described here. Remember Citrix was developed in the 1990s... the days of Windows NT 3.5/4.0 [1] & Dial-Up connections and to be able to function well in these low bandwidth environments (we're talking kilobits here people, a 10 Mbps LAN was considered glorious at the time). For years ICA was superior to RDP due to its better compression over such connections. It sounds more like whoever setup your environments didn't know what he was doing and the results are what you would expect.

[1] https://www.youtube.com/watch?v=SNJiWPU4HEU
In VFX and animation production there is a "firefighter" position similar to the Staff Engineer: a senior level developer unassigned to a specific project, able to float as needed and provide support and solutions for other projects that need spot senior level support. At some studios this role goes to sr. and lead developers whose projects are canceled/halted until they can be reassigned. At others, it's like a mini-sabbatical for sr level technical staff that would otherwise leave, but the company does not want them to leave.