skysight-inc/HackerNews huggingface dataset:
Oncologist here.
You can think of drug development as an extremely wide funnel with a minuscule exit hole.
At any given time a medium sized pharmaceutical company has 300-500 drug candidates.
From this group 50 make it to phase 1 trials. 40 get slashed due to toxicity, company abandons them, gets bought by third party and sits in sleepy storage.
10 advance to phase 2 trials where 5-8 may not end up having enough efficacy/too toxic, does not improve survival.
The remaining 3-5 advance to phase 3 where they can suffer the above as well.

Tl:dr: Things usually work in the lab where all ideas start. Until a compound goes through thorough human experimentation believe little.
Are you able to talk about what you're doing in help desk that still pays so (relatively) well? This honestly sounds like a dream to me.
> if your setup for postgres has a SSL certificate you're doing something terribly wrong to begin with.

No, that's a bad take. We should encrypt everything. The reasoning for not doing so in the past was computing power. Nowadays, that's really not a problem. Even my personal servers in my home network are all operating with encrypted links - because why the heck not? At work, everything that can be encrypted is encrypted, otherwise it's a bug. Even if currently 'there's no way' for attackers to get to that particular network. Emphasis on "currently". We shouldn't be a compromise away from leaking everything. Defense in depth.

Plus, the more you are familiar with setting up encryption, the less tempted you are going to be to cut corners when you are setting up something that's at a higher risk.
I’d tell FB where to go.
Yes definitely agree.

Overall the UK grid is probably too dependent on wind energy, with all the variability that involves.

Right now gridwatch.org.uk is showing about 13.5GW from wind (40% of demand), but I've seen some days when there has been well under 1GW.
Yes? That's how most rules work. They don't define everything precisely, we just agree that stupid behaviour and abuse attempts are worked around. This applies to pretty much everything.
Shit. My best to you and yours. Thanks for sharing.
Yes, but the grid in Europe is generally so reliable (especially when not living in a rural area), that such stability might be taken for granted.
This is something that's actually studied in cognitive science, you're free to watch the (very long) lecture series if you're interested, the transformative experiences being discussed are very much not about "some weed smokers."

The series is pretty clear about the actual contents of altered states being largely garbage, so your observation and skepticism regarding "amazing ideas which they somehow can never write down and keep for later" is exactly in line with some of what's being discussed there, not contrary to it.
That commercial is hilarious. Everybody is clearly mocking this dipshit for wearing a VR headset in public.
Uhm, no? I can only imagine you can't read...

It's the same old techbrother hype over nothing /WITH BITCOIN/

I kid, of course. Even as a bitcoin fan, this stuff is really embarrassing.
Ah that sucks. How old is the tv? And what’s the brightness in it?

My 3 year old Panasonic gets used a lot but we keep the brightness down to the 45–55% range (it’s plenty bright) to avoid burn in. We also don’t display static content on it. And when we do, it’s mostly from Kodi which dims itself after 10 min or so.

All that to say for those who are fearful of OLED because of burn in: don’t be. With some precautions, it’s fine. And having true blacks is absolutely glorious. I enjoy it every time I use the screen.
1. Copy link address
2. load archive.is
3. search for snapshot -> paste

Here you go:
https://archive.ph/uVvn1
Perhaps, but I can only remember personally experiencing a total of three power failures in the UK before I moved out in my mid 30s (and that includes the one time in the converted stables in the middle of nowhere, Wales).
Money is absolutely an object. People are starting to do trials of early detection from circulating tumor DNA, and finding that the hit rate is alarmingly high. A decent portion of the population has some kind of malignancy, but most of these will either be cleared by the immune system, or be completely benign. Another problem is, if we detect this tumor DNA, it doesn't tell us where in the body the tumor might be. So then you're talking massive workups including while body CT scans and such for a problem that isn't going to be a problem for 99% of people. I'm not joking when I say that if rolled out as is, this has the potential to bankrupt the entire healthcare system with unnecessary procedures.

To be clear, I very much think that early detection of tumors will someday be an essential part of cancer treatment. We are not there yet.
Musk Asks Delaware Judge to Halt Lawsuit over $44B Twitter Deal
My conclusion from trying to get erlang distribution works across regions is, just don't. Distributed postgresql on fly.io is cool .. though only for read heavy.
Are you referring to the vaccines administered to several billion people, that are proven to be safe and effective?
Chinese stocks do not IPO like that. They create a special shell company that is entitled to the profits of the company, and they ipo that shell.
I once described a few of my earliest memories to my mom, who politely listened and then showed me the photographs that implanted those memories in my brain. Of the five earliest "memories" I have, two of them are based on pictures of me as an infant, well before I could actually have formed memories. One of them was a thing I'd never actually done, but there was a picture of my brother doing it as a kid. I'd just seen these photos years ago, and told a story about them happening to me which had neatly and imperceptibly replaced my memory of them as photographs.

I wondered when that phenomenon stopped: could it happen to me as an adult, even today? Almost certainly. Probably happens all the time.
TIL how a subpoena can work. I had no idea.
> I must agree. The most important thing for a writer would be the audience: "For whom am I writing" It may be very well the case, what he was writing was not correct for the audience targeted by the editorial.

Yeah but why is it "not correct" for the targeted audience? According to the author, prudishness.
Do those studies link "wood smoke from indoor fireplaces" or just "wood smoke" to lung cancer? The level of smoke exposure from a modern indoor fireplace is considerably less than from an outdoor fire pit.

I will happily have my fireplace burning all day long on a subzero winter day, throwing on the occasional fresh log. But if I have a bonfire outside in summer, I need to be standing upwind.
People who do this sort of thing are incredibly rare lol. Most interracial violence is black on white.
> If you've never been in a secure datacenter when they throw, it's fun.

I find your ideas intriguing and would like to subscribe to your newsletter.

Seriously, though, do tell us more.
Intent to sell is the key bit there. You can sell a gun you made yourself if you didn't make it with the intent to sell it.

In the context of gun buybacks, there is generally some promise of amnesty that prevents enforcement against these illegal gun manufacturers. If they were pulled over on their way to the gun buyback, they could probably be successfully prosecuted.
That's why I said the marathon sport and not just running to/from Marathon :)
Cloudflare Total TLS: one-click TLS for every hostname you have
This remembers me to the story of the UK trying to eliminate cobras in India. They offered some money in exchange for a dead cobra. It turned out that the locals started to farm cobras to get the bounty. After the government understood it was not working, they stoped the program. All people farming cobras left them in the wild... at the end the amount of cobras was a multiple as the beginning...

It is difficult to make good public policies.
Purely anecdotal, but when I took acid once in college, I became strongly aware of these patterns in the concrete outside my house, kinda of a swirly "leaf like" structure. Long after the trip had ended, I could still see that pattern, although less pronounced. I had to look a bit harder to notice it.

My theory is that the pattern was always there, it just took acid to let me really notice it for the first time. Something about the way that the concrete dries, or maybe an artifact of whatever they do to freshly poured concrete to make it grippy.

Could also be pure delusion, so, grain of salt. But I think there is something to the idea that a new / different frame of reference and attention can show you things you may otherwise not have noticed.
Android 10 itself is technically still supported with security updates, so nothing wrong with it, if the device manifacturers support the kernel, drivers and firmware blobs... You not caring about those security fixes means you don't use video hardware acceleration, no Bluetooth, cellular, wifi, or any kernel features? It totally agree, of course those old^H^H^H quite new phones shouldn't be scrapped, they should be supported by the manufacturers for, like, 10 years. Instead of buying deprecated-by-design electronic waste, we should just boycott them in the first place and support decent manufacturers instead. In the case of Sony, this will solve itself as it looks like they will give up making phones any time soon.
By the time much storage is being built, renewable power will be the cheapest choice, by far. So, you are worried that somebody up the line will choose to use expensive fossil-generated power instead of cheap renewable power.

Just by preferring the cheaper product, you bias your choice toward being made with renewables. It is not a guarantee, but in aggregate it is good enough.
Maybe Europe but I find it hard to take seriously the claim that the US is more prudish around sex than most of Asia.
En L'An 2000
I wonder how this will affect housing prices in the rest of the states. The bay area has a lot of people, if half of them migrate that's bound to have an effect.
This plus the student loan forgiveness makes it look like Biden decided he wanted young people to vote in the midterms.
consider making .h04_h1.hero min-height 174px - otherwise the 'get started' button jumps around
"Students of Jones’ fall 2020 class wrote an 11-page document outlining their grievances with his handling of the course — not the course content." from the NYU newspaper.

The document: https://nyunews.com/wp-content/uploads/2022/10/Organic-Chemi...
Funny how other crypto bros would say the opposite.

But hey now you got my interest: if it's not for normal people for whom is crypto then in your opinion?
Decoupling: The Most Useful Tool You've Never Heard Of
You don’t believe what, exactly? The quotes? The source from the article is the AP, are you claiming the AP fabricated these quotes?

> In a video circulating widely on social media, Dr. Robert Malone, a frequent critic of COVID-19 vaccines who once researched mRNA vaccine technology, made the claim that the vaccines are “damaging T cell responses” and “causing a form of AIDS.” “People think, when they hear AIDS, they hear HIV. No, the vaccines aren’t causing you to be infected with the HIV virus,” said Malone, during a taped interview with a website that focuses on COVID-19. “They are causing a form of acquired immunodeficiency syndrome, that’s what AIDS stands for.” In the interview, published April 1, Malone claimed that “lots of scientific data” support his claim, but cited no evidence. The claims are unfounded.

https://apnews.com/article/russia-ukraine-covid-technology-s...
Common Core is not the problem, that's just a political talking point. Common Core is not a curriculum, it is a set of standards.

Before Common Core, there were 0 national standards for math (and language skills, but this is about math). The US "standards" were created accidentally, like how Texas sets the standard for many states due to being the largest customer of textbooks and printers not wanting to make separate versions for smaller states.

Common Core simply set the minimum knowledge and skills by grade level, basically saying "students should be able to do fractions by the end of 5th grade."

The major criticisms of Common Core are that it was too expensive to implement for states that were already so far behind in funding their educational systems, and that it's too test-driven, for example tying teacher evaluations to test scores.

In any case, over the last 12 years since it started in 2010, many states have quit trying to implement it and gone in other directions. Most experts agree the overall impact of Common Core is nothing to slightly negative due to the implementation problems.

This says more about our abject failure to properly fund and organize our educational systems nationally, by the way, since the people in charge of implementing the standards in various states and cities did things like LA spending 9 figures on iPads to deliver Pearson tests that only were licensed for 3 years. AKA typical American turn-government-initiative-into-private-industry-giveaway stuff.

And anyway, the oldest child that would have been "entirely educated via Common Core" would be 17 (5 y.o. kindergartener in 2010)
(a) bullet voting isn't actually a problem

https://www.rangevoting.org/BulletBugaboo.html

(b) Approval voting only incentivizes bullet voting when that is very close to actually capturing the voter's intent. The strategic thing to do is vote approve on all those you like better than whoever you think the most likely candidate to win is.
> Every time something like this happens, on such a scale, makes you wonder, how can so many people fall for this?

Does it?

If you're going to work every day to make a dollar, and your friend just sits on his ass and plays video games and makes a dollar every day off his CryptoKitty investments - and you can see the actual money in your friend's account - after a certain period of time, it's hard for anyone to resist, no matter how dumb it sounds.

Even Newton lost all his money in the South Sea Bubble... Twice!
Just this summer I spent a few weeks in three European cities.

Europe gets extra points for all the outdoor seating, but loses all of them because it's impossible to sit outside and enjoy a coffee or a meal without someone lighting up a cigarette next to them.

I do wish Europe would discover non-smoking rules near food & drink.
In some of the examples you provided they the email campaign providers will create a unique SNAT with a unique FCrDNS for the customer if they are big enough so they don't get in the polluted SNAT pool of smaller companies. In those cases they can still be blocked by regex or sub-domain name.

For the generic SNAT pools of the smaller customers one can at least rate limit those providers and also tag them as Possible Spam or adjust their spam score in tools like Spam-Assassin. It's not perfect but tagging and rate-limiting can help.
I've done more psychedelics than I remember. I know I've done LSD at least 35-40 times over the years, and it has been less than 3 months at this point. I'm over 40, by the way.

I can sit there with my eyes closed while on LSD. Same with mushrooms. Mushrooms are a bit more fun with that because of the visuals and patterns - I've spent some hours like this in a hotel in Amsterdam (truffles, obviously).

I already find an MRI relaxing - they give you a button in case anything goes wrong, after all, and they can put music in the headphones. I can definitely just relax there and I can definitely see how it would be pretty immersive. Plus, I'm pretty sure they aren't giving these folks contrast through an IV and that's really the bit I'd have some issues with.
Do you even need a service for this? Couldn't this be a simple static HTML + minimal JS that opens a base64 URL with content-type "text/x-vcalendar"?
the point is the developer audience that is just coming out of college...will not be familiar with postgres.
they would make most of their applications saving data via "Durable Objects" on the edge. Someone just built Kafka using Durable Objects.

Not arguing that DO is better that postgresql. I'm arguing that a lot of the developers wont realise that. Because the DX of durable objects is superior.
Yeah, it looks like this was a combination of students not doing to work/putting in the time, and a teacher who got too old and bitter to treat students with respect. It's also likely that previous generations were less thin skinned, but really nobody needs a sarcastic and condescending teacher shaming them in class over their grades and even previous generations would have done better without it.
Never forget, the company is called Facebook. The Meta rebrand was a desperate ploy to sidestep negative attention surrounding ongoing litigation and to bolster hope in the dying company as they try to pivot toward VR.
"Web2 + Web3 = Web5"

That will scale well.
Keep repeating the mantra and it makes it true.
Absolutely - it's just an abstraction layer over the idea of exchange. If there's nothing to exchange, there's no need for money!
Christian Bale Keeps Trying to Quit Hollywood
Imagine observing American media, from nipplegate, to nipple-censoring, to Carlin's seven words, to censored and sanitized song lyrics in the radio and in the store, to warning labels about 'explicit lyrics', to hyperclean and sanitized Hollowood movie productions, to covered and hidden magazine covers - and still thinking the Americans, as a general default, are not puritanical. Thank you for that.
None of those things are especially newsworthy. They sound like Onion headlines on their own. But when one or more of them happen which could be framed in a way that incenses the public, it becomes a news story because that's how you make money in journalism in 2022.
yeesh – one would hope that would fall under "undue burden or expense" but yeah I guess you never know how this kinda thing plays out until you've been through the ringer (like everything). Thinking again, I can't believe I included the descriptor "straightforward"
Thanks, that's an interesting insight into the dropoff rate for these ideas. Do you have an opinion on what the bottleneck is? Volume of ideas, length of testing, or perhaps flawed approach in general?
> And I wonder why in the world they took jobs as lecturers. If you don't have a passion for teaching, why take a job that pays substantially less than what you get in industry?

I don't know about this specific situation, but many professors enjoy and are good at research and see teaching as necessary overhead in their jobs. Professors tend to have much more freedom than people doing research in industry and for some people that's worth it.
Bloomberg is reporting Musk wants the deal to be contingent on debt financing. Twitter does not like that. So choices are:

a) There is no new agreement. Litigation proceeds.

b) Musk floats an actual walk-away settlement in an amount Twitter would agree to.
> With programming languages, I feel like there's so much dumb, blind luck involved in which ones win

Very true.

Among my favourites:

Apple's Dylan was an amazing language with an amazing development environment. Ignored.

Oberon, the last scion of Pascal, is a great clean blindingly fast language, and simple too, and the OS of the same name is a thing of beauty.

Both ignored.

It's OSes too.

I mean, UNIX was good, for its time... but Plan 9 was better, in terms of network and GUI integration, but the world ignored it. Inferno is better than Plan 9, in terms of integrating the Taos virtual-processor CPU-independence (and a saner GUI than Plan 9, too) but it went nowhere either.

(Yes, licence agreements had something to do with this, but Linux was neither the first nor the last free UNIX. Before it was BSD, notably 386BSD, and before 386BSD was Coherent (not free, but cheap, and showed it was doable.) After Linux... there are dozens.

If people learned from the model, then even if Plan 9 was under some restrictive licence conditions, it could have been cloned, just as UNIX was, repeatedly.

Concurrent DOS was pretty amazing in its day.

GEM was amazing, but only Atari ST fans noticed.

EPOC, EPOC32 and Symbian were great OSes. Symbian is FOSS now. Nobody cares.

Taos was amazing and should have been the new Amiga.

QNX still is amazing, but Blackberry 10 flopped. Huawei's HarmonyOS is vapourware and marketing: it should just licence BB10. It's real and it works.
Linux kernel 5.19.2 code could cause permanent damage to some laptop displays
I do not dispute that. But with a clickbait headline and a long meandering path to the point I don't feel bad about skimming.
Even though those filters are fake news.
All you need to do is convince the agent that you are an American Citizen.

You can show them any identification documents you do have, like drivers license, to establish your identity. For establishing citizenship, one option is if you previously has a passport (expired, or just not with you) then can look up that record, and if it is recent enough to pull up a photo they can compare to you that can also help.

Other ways of verifying citizenship depends on what databases they have access to. For example if they have access to the Social security numident database, they could look up a number to see the associated name citizenship flags. I'm not sure if they do though.

From what I have heard anecdotally is that it is usually not too hard to convince them if you really are a citizen (except in edge cases like being born abroad to Americans without parents registering your birth with the US.)

In any case they will formally warn you about it being illegal for Americans to enter without a passport (it is, but there is no punishment for the crime anymore). This is to deter you from doing this again in the future, as having a passport makes things much faster and easier for everyone.
Somewhat related is the Starlink live coverage map.

https://starlink.sx/
Glad I'm not the only one who also thought the title was some sort of MS marketing slogan.

...or it could also be a pun about Edge becoming another Chrome-clone.
And the places they move to are seeing the effects. Rising home prices here in RTP, NC is making life difficult for those not in the tech sector since wages haven't increased proportionally. Good for us that bought homes even just 4 or 5 years ago, but I feel for those who are just entering their careers and looking to buy or even rent a home.
When I say most of these crypto future project.
I just say good luck and totally ignore them.
If it succeeded we would all know sure enough.
> A lot of people in Europe drink a beer or glass of wine when having lunch. It's completely normal.

When you live in a culture where a midday drink or drinking in front of children is associated with drinking problems, soon enough you will live in a culture where only people with drinking problems will be having a midday drink or drink in front of their children.
The Bay Area is one of the few where half of the residents could move out and they would still have a housing crunch.
Look at GRAIL therapeutics. Cancer sheds DNA that can be detected and amplified. We use this sometimes to try to tell if someone will have a recurrence before scans actually show it.
Sequencing is hard, and there are contaminants and difficulties calling a mutation/sequence cancerous, but I have had patients self-refer after a positive GRAIL test, no symptoms, and bam, biopsy from area of interest shows early cancer.
streaming live is hell expensive
> There are really three. There's the professor's side, the students' side, and the administration's side.

Actually four: 1) professor's side, 2) the students' side, 3) the administration's side, 4) and society-as-a-whole's side.
They did? Oprah just ended a multiyear content deal w/Apple; Ted has dementia.
Hollywood might not be downright puritanical, but compared to European TV they make a much bigger deal out of upper body nudity and swearing, among other topics. There are a couple of exceptions (HBO comes to mind), but as a general rule Hollywood definitely isn't running wild (except when it comes to violence).