skysight-inc/HackerNews huggingface dataset:
I've heard secondhand from people who took his class while at Princeton, decades ago, that his courses even then were notoriously and anomalously hard in comparison to organic chemistry courses at other Ivy League universities, and in comparison to other courses within the department. They're alarmed that this has become a "culture war" issue.

If there is a culture clash, it is that the "gen Z" students finally organized and collected evidence to back their claims that his teaching was having negative effects beyond those originally intended by the institution, and were not afraid to take it to the institution. That's a good thing, in my book.
Thanks for sharing your story and treatment details. I should add that my relative's cancer has no particularly interesting mutations, but does have a high PD-L1 expression, which from what I can tell is the reason Keytruda was more likely to work for their situation.

> that was geared towards my specific mutation

This is actually one of the things that gives me hope for the future: genetic testing on a tissue sample of the patient's cancer is standard, and for many of the specific oncogenes that we know about, there exist therapies targeted to those specific mutations: https://www.cancer.org/cancer/lung-cancer/treating-non-small...

One thing I've learned is that even in the face of good news, cancer is a horrible time, and I wouldn't wish it on anyone. But I'm likewise glad to hear about your results from the latest treatment, and hope things stay as positive as they can for you.
Medium/Moderate Cost of Living?

Just a guess, but seems likely in context.
Did I say anywhere that she wasn't a conservative? You clearly misunderstand the no true Scotsman fallacy.
I'm curious as to what differentiates cannabis from other psychedelics such that you think there is a healthy path to it and not to anything else.

I personally think turning to psychedelics as form of subjective exploration is perfectly healthy, despite the risks.
Simula isn't even an American company.
PG&E started voluntarily turning off power to entire towns to avoid fire hazards... fire hazards that were self-made and exist only because of other failures that have piled up for the past few decades.

So the current situation is something along the lines of when the wind blows too much, they shut off the grid. When it blows too little, they shut off the grid. When it gets too hot, they shut off the grid.

It's crazy that this is happening in California of all places, but decades of poor policy decisions led to this and it'll take quite a bit of time to undo.
Medium cost of living, perhaps?
Uber is partnering with Motional to launch driverless rides later this year
I was aware of the fact. But did not know it had a name.

What I'm also aware of, and I do not know if it has a name: when BS is mixed with truth, then is almost impossible to debunk. If you have the right mix of facts, truth and lies, well packed together, then you have a tool to convince almost anyone of almost anything.
As I read it, the author and wife both had t-shirts on, and the wife was taking hers off. There was no previous shared state where they were both less dressed than that.
Supreme Court to Hear Case over Algorithms
Medium Cost of Living?
That is a hard thing to capture, but strategy is a decent way to approximate it. I do think this is fair criticism for what it is worth, but I don't think anyone has been able to create an accurate model for this (for any voting system) and I'm not sure you can accurately model this tbh.
We’ve seen this play out 100 times before.

Another poorly written show, where the writers attempt to “reimagine” or “correct” a work of art that fans have held dear for many years.

When those fans voice their concerns or complaints, they are called some form of “ist” and ridiculed by the show runners.

In the end, money talks. And these cash grabs are not grabbing anything - they’re losing long term customers and hemorrhaging money.

Chris Gore has an excellent summary of this:

https://youtu.be/Tv9u9Nwi6Y4

https://youtu.be/vPB0gR7e9IY
Looks cool but...why not just send the .ics file directly via your IM of choice? Am I missing something here? I don't see the benefit if you still have to click, open file in your calendar, add it to the calendar.

Can you tell me why the above wouldn't work and why this is better?
Is there a difference between firing and not offering a new contract to someone who was on year-by-year contracts? Particularly someone with, as you say, a history of non-excellence?
If your country do those things, some people might feel is hypocritical, because a citizen of {evil_country} have nothing to do with {crimes}. Just because Alice's country did it long ago, doesn't mean Alice have the higher moral ground over Bob. Again, just pointing out what it is. Don't care, TikTok, Facebook, Snapchat,etc can dissappear tomorrow, and I wouldn't notice.

Edit: Typo
Encrypting data on the web and confidential computing
If there is public policy support, it needs to exist for all manufacturers. Otherwise it's not legal in the EU.
>Another problem is, if we detect this tumor DNA, it doesn't tell us where in the body the tumor might be.

This isn't necessarily the case. A lot of CTCs have markers that are indicative of certain cancers or tissue types of origin. Different tissues have specific patterns of gene expression even if they all have the same underlying DNA, and there are databases with thousands of samples sequenced supporting these patterns.
I had a roommate who moved to America from a third world country.

He had heard that Americans don’t let children drink alcohol. That sounded puritanical.

When he arrived in the US, and saw people drinking more alcohol in one night than they drank in a year back home (this was hyperbole).

I’d drink with him. One shot of rum a night - no more, no less.

Americans aren’t one shot drinkers. We drink too much. And so do many Europeans.
It's just browsers not having generic vm. It just not be able to run more than one programming language. (ok, wasm..). Other VM has a bunch of dialect of its langs run on them.
Unfortunately he doesn’t go the full distance and tell us unambiguously whether or not he clicked on said shortcut. Which would say nothing about the already settled macOS question but would say something about Firefox.
I did the same and haven't looked back. I can take a walk without wandering through a sketchy bum colony. The streets aren't lined with RVs. My property tax is in the single-digit thousands of dollars.

I was able to get a concealed carry permit, but ironically, I only carry when I have to travel back to the Bay Area.
The death of Silicon Valley has been stated and overstated for decades now. This isn’t the first “exodus” we’ve had, and it won’t be the last. But somehow, new blood finds their way back here every time.
When I get into obscure areas, I definitely get the sense we're remixing a small library of basic components (I've been generating variations on "19th century hand painted wallpaper" with stable diffusion recently). In this niche I have less and less confidence I'm not just getting someone else's work that's been put through the intellectual equivalent of a bitcoin tumbler.

But I don't really know enough about the this particular black box to have an informed opinion.

Maybe I'd get broader results with one of the commercial players, but maybe that's only because they have a bigger library of basic components.

Actually, you know what? We know it's just a remixer, because sometimes the shutterstock logo peeks through.
Why the US did not go metric [video]
A quick web search shows there maybe some free alternatives. Not sure that is helpful, but I was curious myself (even though I don't use Figma or Adobe).

https://mockitt.wondershare.com/software-design/ui-design-so...
I would love a AI model that does text-to-SVG.
Do it. We got probably 5x the amount of house than we could have gotten in the Bay Area and we don't have to worry about our car windows being broken. We now live close to nature and I'm in such better shape being able to trail run, mountain bike, and snowboard minutes away from our house.
Try being strapped to a hospital bed in foreign country experiencing the most traumatic hallucinations and unending loops that are beyond the imaginable. Do not fuck with strong acid.
Problem is, American media doesn’t just show violence, it glorifies violence, whereas perfectly normal behaviors are being censored out.

This of course has a rather obvious explanation, but HN prohibits mentioning it for political reasons.
> Humans decline mentally & physically as they age. Sucks, but it's true. This guy in his 30s was maybe a great teacher. That was in the 1970s. It's 2022.

Sorry dude. In some ways that's true, in other ways that's not. IIRC, certain kinds of "mental agility" decrease as one ages, but that can be compensated for by increased experience and knowledge. Your comment also reads like classic techie ageism.

How much has undergrad organic chemistry changed since the 70s? My guess: not much. If the guy still knows his stuff (and he almost certainly does, given he wrote a widely used textbook), and he could teach well in the past, he can almost certainly teach it effectively now. IMHO, that can be hard to grasp for tech people, because so much of our knowledge is obsoleted quickly by various kinds of churn. I'm getting zero indication that the issue was that he was befuddled or anything like that.

> Looking at it from a distance, if a group of students think your teaching style sucks so much that they put together a petition to get you to change it, that's just fundamentally a failure of your teaching style. He might want different students, but tough, these are the ones he's got. If he can't hack it with them then by definition he is a shitty teacher.

That's bad reasoning, on the order of "he must be guilty, otherwise they wouldn't have arrested him." By your logic, it would be his failure as a teacher if he failed to teach a class of literal illiterates Organic Chemistry.
American republicans are consistently against RCV simply because it consistently makes them lose more because there's more broad support for more middle of the road contenders. Before republicans realized they should fight it, and started running a narrative against it, you could have asked any american and they would not have had a notable opinion on voting methods.

Any fight against RCV is purely a republican fight against more equitable and realistic representation for americans. It's not hard to understand, as plenty of schoolkids use RCV every year for school and mock elections. It is strictly better than plurality voting in terms of getting more people elected that more people are at least a little happy with. It by and large results in a more represented public.

If, by some magic, we end up in a world where politics is a utopia and the extremely contrived "issues" with RCV finally are worth caring about, THEN we can move to replace it, which will be easier in an environment that allows more nuance to politics, like RCV does.

For now, RCV is an easy way to get a broadly better political system. It is currently only disliked by like 1000 turbonerds who spend their time making absurdly complicated voting systems to solve ever more contrived voting situations, situations that broadly aren't the problems currently facing the world, and every other opponent is a republican who either believes incorrect partisan rhetoric ("it's more than one vote!") or cynically understands how it will cause them to lose elections and for some reason think that's a bad thing.
Objectivity precludes responsibility (1984)
If you want to know the result of successive Tory governments and forty years of deregulation and mismanagement, then power blackouts and people not being able to heat their homes is it. The Tory agenda now seems fixed upon ensuring the very rich have everything and everyone else has absolutely nothing.
What they may or may not desire is less relevant in the face of what external bodies compel them to do
Wow, that's a lot of bullshit in one comment.

- "Conversion therapy" generally means programs designed to make children straight, and I have never heard anyone use it the way you're using it

- Puberty blockers are routinely used for precocious puberty in non-trans children, and are no more dangerous than any other routine medical intervention

- Given how difficult it is for minors who themselves insist that they are trans to access medical care, and the fact that I can't find any credible reports of such things happening, I don't believe you when you insinuate that adults force children into transition

- Being gay doesn't require sexual activity; we accept that straight minors can experience romantic feelings, and it's not at all frowned upon in American culture. Asserting that gay minors cannot also experience romantic feelings is simple homophobia. I was a bisexual child before I became a bisexual adult, and I dated people of the same sex in high school.
This is true. I make $150k a year and Boston area rent prices + cost-of-living makes me live close to paycheck-to-paycheck. (I'm not there, but I can save very little even though I try to live frugally, prices are insane!). I simply cannot comprehend how low income people live in major American cities, you'd have to live with many roommates and be very food insecure! Life is hard in the US [1] right now!

[1] In the cities. I'm guessing life in suburbia/rural towns is easier. I lived in a major city my entire life, and living in rural parts of the country not worth it unfortunately. It's my own personal decision, I understand that it comes with significant trade-offs.
True, but it's been done for decades at least if not longer (considering things like smallpox/cowpox). Nobody was forced to take the Covid vaccines to exist. They were required to interact with people in certain areas and activities. Are you proposing that the rights of the dissenters were more important that the rights of those interested in reduced risk?

So it's not inconvenience, it's selfishness?
It's unfortunately federal law, he had no say in the matter if they could work for him. As federal employees you can't consume marijuana (go get blasted at the lobby bar at the Watergate though, no worries there)
Colorado?
And what if it’s a midday cigarette? Both have moderation and addiction. Perhaps the image of a loving grandpa smoking a tobacco pipe would alleviate the stigma.
So what I think the parent is referring to is called the Favorite Betrayer Criteria[0]. The short is that there are two forms of the spoiler effect: strong and weak. RCV handles the weak case but does not handle the strong case. I explain part of why cardinal methods handle the strong case in this comment[1]. The truth is that we're far more concerned with the strong case than weak case because from our current position this is the more frequent type of spoiler (and arguably is more frequent in general).

[0] https://electowiki.org/wiki/Favorite_betrayal_criterion

[1] https://news.ycombinator.com/item?id=33111242
The one with Amélie was certainly very harmless, the other ones were a bit more spicy. Yet this shows the difference in thinking between America and Europe.

Warning, NOT SAFE FOR WORK:

For context here's the sex scenes in question: https://www.youtube.com/watch?v=p6wqunhUVWo

(I checked the guidelines, it doesn't mention anything adult related. Hence that should be okay here.)

Judge for yourself.
Speaking of zerocal, have you ever noticed that low calorie packaged foods like pickles and cauliflower will put tiny serving sizes on the package so they can advertise 0 calories? I think they round down to zero when it's less than 5 calories.
Sounds like they had some underlying issues if they were doing "lots" of hard drugs at age 15. Hallucinogens likely didn't cause their issues, just made them more apparent.
I think if you're skimming longform and then criticizing it you'd be better off just not reading it at all.
Anecdotally speaking re: RTP, NC but I think the area may have peaked back in summer. Inventory is sitting much longer. I know sellers who sold under asking for a price much more similar to previous years recently.

New construction is always a bit behind here and we will definitely see higher prices in central NC with the various tech companies increasing their presence in the area.

But it was complete bonkers until August. Sellers were getting double-digit all-cash offers 10%-20% over asking price. Never seen anything like that here before.
By sharing.
You can always check his Wikipedia page, where the "Criticism" section is longer than the "CEO" section.
> otherwise your home battery might be attempting to power the entire (local) grid which of course doesn't work.

and some random line worker may think there's no electricity flowing when there is.
It's not that it can't be done well, it's that it's not likely to be done well, especially at a large org.
The Austin housing market is insane. And with Texas getting a large chunk of their income from property taxes, there's going to be some very major effects when everyone's homes start getting reappraised for tax reasons.
If you think that anything written in 4pt font on a website can turn "fraud" into "not fraud", I got some sweet bridgecoin I could sell you.
Depends on the podcast but Hidden Brain has always been more on the easy listening/infotainment side of things, rather than something more serious.

You might like The Economist, which has the entire publication professionally read each week, and you can listen at 2x speed, just like a podcast.
"But, while Section 230 protects websites that remove content they find objectionable, it is far from clear that it protects websites that promote illegal content."

They are suing google because youtube boosted videos that they say incited people to violence, leading to acts of terrorism. The suit is about whether promoting content should have the same protections as removing content does.
> "The editor is probably right to cut that line in translation."

I can't agree with that. As a non-European, if I'm buying a translated work from a European author about a European character, I expect them to behave as ordinary Europeans would. I am paying for the authentic foreignness.

If I wanted to see people behaving as they would in my own culture, I'd buy a work from a domestic author.
> But I’m terrible in areas such as algebra, which rely entirely on abstraction and provide nothing to visualize.

but also

> I could do trigonometry by visualizing, for example, the cables on a suspension bridge. But algebra: no.

????
> they don't give you water for free like in the U.S.

Well, to be fair, what you typically get in Europe is a nice bottle of mineral water, while in the US they just give you tap water (which would be considered faux pas in Europe).
I think the problem here is ordering. At the end we probably want them to know X and Y but we would rather they learn X then Y.

But to learn X they need to do some steps from Y.

If we can remove those steps we can make more people learn both.

But also in practice I don't think anyone struggling to set up their env before writing a line of code is learning much. They are just following arcane instructions until it works.
In my experience Asia (I lived in Korea, so my experience is primarily indexed against that) is far more prudish than America when it comes to sex.

My question, is how did Europe develop its seeming openness to sex and nudity? 1950s and earlier Europe looked a lot like America, maybe in that time America even seemed more open with sex. Europe produced Victorian prudishness, it used to be the norm for women to cover their hair, etc. It's not like Europe was always seen as a place that has been really open with sexuality.
> just not new coal fired plants.

Or hydro-electric, or nuclear, or anything that would have meaningful impact on the state's situation.

More solar and wind are great, but they do not respond well to surges in demand, and there is no current way to store energy either.

So some impressive total production number might sound great, but the reality does not follow unfortunately. For a non-trivial portion of the state, electricity isn't a guarantee throughout the year anymore.
government is via consent which literally includes all the other things you mentioned
I don't think anyone was suggesting you should still be fine with Alex if you caught him manipulating you, only that it's silly and pointless to be immediately distrusting and demand a bunch of evidence when someone makes a claim that doesn't matter. That is, be generally trusting of Alex (and everyone else) as long as the stakes are low.
They built the place 30 miles inland. Source:

> The community is located 30 miles inland to avoid coastal storm surges.

Of course any given finite buffer can be overflowed by a larger finite threat.
I'd bet that they do some of that, too, but if you've got 100 images you want to get "perfect", it's probably faster to capture 10 of them uncalibrated, guess at the curve, capture those same 10 and 10 more calibrated with guess #1, and make a second guess, for a couple iterations than it is to capture all 100 images before any calibration and then all 100 again afterwards to confim, especially if there's any slop in the calibration curve.
You can trade crypto in person without an exchange
Yes, houses in nice areas with desirable amenities tend to be expensive, because (no surprise) demand to live there is high. Most of these areas also have the common problem of local government that is very heavy-handed in the zoning in permitting of new housing construction.
> why take a job that pays substantially less than what you get in industry?

This is really only the case in the last 15 years or so. The vast majority of programmers weren't making into the 6 figures. The pay might have been marginally worse at a univ, but the benefits, QOL were probably better.
What is the science behind this? Is it not obvious that most people want to pick a single alternative? And for precision. If you force people into ranking. Is it not obvious that the effort that goes into picking the top alternative is much higher than for let us say the fifth option. Basically, adding noise that may skew the results.
A technique to see full-fledged hallucinations is to stare at one point for while, without moving your eyes. While you are staring at one point, focus your mind (in the right way that you just need to figure out yourself), on the thing you want to see, for example focus on Super Mario and you should be able to see Super Mario appear in front of you.
With BTC transactions via lightning, at least, there’s simply a periodic net settlement.
He is a writer :D
Yes, the steel required to withstand the force of the magnets, and to be dense enough to prevent hydrogen from leaking, magnets powerful enough to contain thebl fusion reaction, cooling systems to keep the superconducting magnets in close proximity to the neutron rain at extreme low temperatures.

These are all the parts we know about. Then, there are all the systems that no one has attempted yet that you will need to actually extract some energy from the whole thing, and to inject fuel into the running reactor, and to recycle tritium.

Overall the reactor vessel has to be built similarly to a high-pressure submarine, but it needs to withstand even higher forces. Not exactly something that can be done cheaply, even though we have been building submarines for a good 50 years.
Steam Deck and Docking Station now in-stock and available
That's because America is not uniform or homogenous. I live in the one state in the country where prostitution is legal, and one of the few where gambling (outside of tribal land) is legal - and yet, the state immediately to the east is the Mormon capital of the world.
Electric shocks are already happening (Magnus and David Howell): https://www.youtube.com/watch?v=bzczVRvGOLs